<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7H0</accession>
    <name>L0A7H0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231716.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0023"/>
    <dbReference type="EnsemblBacteria" id="AFZ69818">
        <property type="protein sequence ID" value="AFZ69818"/>
        <property type="gene ID" value="Calag_0023"/>
    </dbReference>
    <dbReference type="GeneID" id="14211284"/>
    <dbReference type="KEGG" id="clg:Calag_0023"/>
    <dbReference type="eggNOG" id="arCOG03700">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081192_0_0_2"/>
    <dbReference type="OMA" id="WLPPANY"/>
    <dbReference type="OrthoDB" id="102239at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04231">
        <property type="entry name" value="Rusticyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001243">
        <property type="entry name" value="Rusticyanin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="222" mass="25329" checksum="662F5F76960C303E" modified="2013-03-06" version="1" precursor="true">MNKLIWLAIILTLGLAISITGIAYYLNYKEYYNNINNYYNLQSFTRYPINESMELANEIPNYVHIYKNNNSIVIDNNNINLVVLAMMGNDAANMTNSTVPSYSHGDVFVIYGLINPTLIVPSGSTIHVLFINLDDDMYHNFIITTTPPPYPYNVMPYVGMNGGMGPSMRLYMTWLPPANYNNNYAYGYEYTFIINSPGNYWYLCTYPGHAENGMYGEVISLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7K4</accession>
    <name>L0A7K4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0062"/>
    <dbReference type="EnsemblBacteria" id="AFZ69853">
        <property type="protein sequence ID" value="AFZ69853"/>
        <property type="gene ID" value="Calag_0062"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0062"/>
    <dbReference type="eggNOG" id="arCOG05316">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069088_0_0_2"/>
    <dbReference type="OMA" id="PRTKFPG"/>
    <dbReference type="OrthoDB" id="59688at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="248" mass="27561" checksum="50A2CF709DD25679" modified="2013-03-06" version="1">MSARPTDLMIKCMGSFIEDKDYVYHGLDSILPQLAMVYASLYLKKDFIFHSVAEPFLVDASQVLIRPSTGDPHSESSGIATVTTIDAFDLAAKGKMDLMYFGTAQIDEYANINLTSIGSYDNPKVKLPGGAATAYLYPIVKKIVIWARHDPRVLVKKVDFITGNGKMRIDNNLKTVLCTNRALIEFTKNGPILRAVFQGYDVEQVLNTGGMKISVPDKVDIIKELNEEELNVINKADPNGLRYEENYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7L0</accession>
    <name>L0A7L0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hexulose-6-phosphate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0067"/>
    <dbReference type="EnsemblBacteria" id="AFZ69858">
        <property type="protein sequence ID" value="AFZ69858"/>
        <property type="gene ID" value="Calag_0067"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0067"/>
    <dbReference type="eggNOG" id="arCOG00053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081825_1_1_2"/>
    <dbReference type="OMA" id="WEQAQEW"/>
    <dbReference type="OrthoDB" id="54384at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="231" mass="24392" checksum="E54FD9CB20FB9B62" modified="2013-03-06" version="1">MNNLVMSLVERVEKCNKLLQIALDFIDINPAISIASSVERKENLILEAGTPLIKSYGINSVKILRSFNGNHLVFADLKIMDVGALEANLAFSNGADAVSVSALTNLETIKETVEEANKWGGAVYGDLIGVDNIEQGIKKLKDAKVHVALLHIGIDVQVKLGLTAGKALDLIKKMKESFGGIIAVAGGIKPEEVSSIASAGADIIIIGGGITKAKDPSYATNLAIKNLNSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7L9</accession>
    <name>L0A7L9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deoxycytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0021"/>
    <dbReference type="EnsemblBacteria" id="AFZ69816">
        <property type="protein sequence ID" value="AFZ69816"/>
        <property type="gene ID" value="Calag_0021"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0021"/>
    <dbReference type="eggNOG" id="arCOG04048">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103451_2_0_2"/>
    <dbReference type="OMA" id="WDAGYEG"/>
    <dbReference type="OrthoDB" id="94658at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="2">
        <location>
            <begin position="76"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="157" mass="17739" checksum="FD57214A8EC3CCDF" modified="2013-03-06" version="1">MAYNGKEMSNYIKGINESQIQPAGVDLRLDKVFKFIEEGYLGEGKRVLPNTEEIAPIDNLYDLSKGAYKIRFFDIVEIPKEAIGICFPRSSLLRMGANLSCALWDPGYSGRGEALLNVLNDKGIKIEKYARIAQIIFIKLKDIPDKLYNGIYNNENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7M6</accession>
    <name>L0A7M6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enzyme involved in biosynthesis of extracellular polysaccharides</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231771.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0083"/>
    <dbReference type="EnsemblBacteria" id="AFZ69873">
        <property type="protein sequence ID" value="AFZ69873"/>
        <property type="gene ID" value="Calag_0083"/>
    </dbReference>
    <dbReference type="GeneID" id="14211343"/>
    <dbReference type="KEGG" id="clg:Calag_0083"/>
    <dbReference type="eggNOG" id="arCOG05403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182726_0_0_2"/>
    <dbReference type="OMA" id="YLIYSEW"/>
    <dbReference type="OrthoDB" id="109093at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="100" mass="12132" checksum="8D0FB65A06C42785" modified="2013-03-06" version="1">MIKRTVNVGLYYKVKEDHEKEFESIFFEMVKKLKEMRIGFIDAKLYKRVDEPREYLIYSEWESLDSFRKFVSSNEFRDTTGYGASILEGRPFHRIFQELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7N4</accession>
    <name>L0A7N4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor synthesis domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231729.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0038"/>
    <dbReference type="EnsemblBacteria" id="AFZ69831">
        <property type="protein sequence ID" value="AFZ69831"/>
        <property type="gene ID" value="Calag_0038"/>
    </dbReference>
    <dbReference type="GeneID" id="14211298"/>
    <dbReference type="KEGG" id="clg:Calag_0038"/>
    <dbReference type="eggNOG" id="arCOG00215">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_0_5_2"/>
    <dbReference type="OMA" id="IGNVIVM"/>
    <dbReference type="OrthoDB" id="61519at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="9"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="268" mass="29701" checksum="038E5A7F85D9A4E8" modified="2013-03-06" version="1">MIKNEVKAWILSIGNEILIGRITNTNATWLSKRLTFLGVKVTRIITVPDEIDDIIEELRRGLNNADLIITTGGLGPTYDDKTIDAVAKAVNKKLVLNPIAYNMIKAKFEKSNLPMTKEREKMAYLPEGGIPLNNSAGTAPGLFLEINNKIVISLPGVPKEMEAIFEEEVINKINKILPPISVIECGFKLEGVPESSIAPILEQVDKKFSNLYIKSHPKGIEVSKPILEIKVLVSDKNKEEARKKAEGALQIVKEEAKKLNGKISEEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7R9</accession>
    <name>L0A7R9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231816.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0130"/>
    <dbReference type="EnsemblBacteria" id="AFZ69918">
        <property type="protein sequence ID" value="AFZ69918"/>
        <property type="gene ID" value="Calag_0130"/>
    </dbReference>
    <dbReference type="GeneID" id="14211390"/>
    <dbReference type="KEGG" id="clg:Calag_0130"/>
    <dbReference type="eggNOG" id="arCOG01280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_2_2_2"/>
    <dbReference type="OMA" id="FSWYEPM"/>
    <dbReference type="OrthoDB" id="44046at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="392" mass="43545" checksum="E99C30F107A0FCFC" modified="2013-03-06" version="1">MRSNIFMKDRVAIVSAGLTKFMRRAQETPRELAWEAAKMALDSAGLTLKDIDCVVIGSAPDTFDGMHFKGEYLADGSGAINKPMTRVYVGGGTGVFVPEAAYWHIASGLCKKVLVVAEEKMSPAHPHPQYVFKYIWDPILERPLGPNLIWIFAMEMRRYMAKCGAKKEDIALVSVKNKRNALDHPAALTAANITVDDVLKSETLVWPVNLLDVSPVTDGAAALVMTSENVAREITDTPVWVEGVGFTLENQHWYNRELAFPRYLNYAARMAYKMAGIERPWKEIDVAEPYDPFDYKELHHIEGLMLARPCEAYKLVREGYFDRDGELPTSPSGGLLGVGNPIAAAGTMKVAELFWQLRYEAGKRQVKKPVHKAVANAWGDLMQAGTVIVLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7Z8</accession>
    <name>L0A7Z8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231854.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ69956">
        <property type="protein sequence ID" value="AFZ69956"/>
        <property type="gene ID" value="Calag_0171"/>
    </dbReference>
    <dbReference type="GeneID" id="14211431"/>
    <dbReference type="KEGG" id="clg:Calag_0171"/>
    <dbReference type="eggNOG" id="arCOG02283">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1248231_0_0_2"/>
    <dbReference type="OMA" id="HIRNAER"/>
    <dbReference type="OrthoDB" id="78391at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH bat-type" evidence="1">
        <location>
            <begin position="165"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="221" mass="25411" checksum="AB29D33BD8B645F5" modified="2013-03-06" version="1">MLILDLTVKSDCGLSKISHDINQEILSLSVFPINEKLNSVTIMLKLLERGSDYELKRWKVRYSDFTKFDLNKIGKSTFIINGVKEGHGIVKTLVKYDSALLMPTIAGDNYERFLILLKNKKNLDSFIKEITSGNKILNIDYNEASTGIIISWMSKVLLDVGNISKREYEVLYNAYKYGYFNWPRKINVDALSKKLEISQPNLLYHLRNSIYKLLSNILSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0A814</accession>
    <name>L0A814_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0226"/>
    <dbReference type="EnsemblBacteria" id="AFZ70008">
        <property type="protein sequence ID" value="AFZ70008"/>
        <property type="gene ID" value="Calag_0226"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0226"/>
    <dbReference type="eggNOG" id="arCOG13721">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2079300_0_0_2"/>
    <dbReference type="OMA" id="WCIGLEN"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="117" mass="13556" checksum="181C6D6BE21642D1" modified="2013-03-06" version="1">MDHNKEIMKGNTFLHLVLTLFCNNNSWCIGLENVLDMHINKLIARNVEEILSQLGDIEKRYNSLGEDDESRLEKIVLNHMRKILLDDLRQITGFSSYYGYDIRVEPSVSLENSEAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A818</accession>
    <name>L0A818_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231874.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0193"/>
    <dbReference type="EnsemblBacteria" id="AFZ69976">
        <property type="protein sequence ID" value="AFZ69976"/>
        <property type="gene ID" value="Calag_0193"/>
    </dbReference>
    <dbReference type="GeneID" id="14211453"/>
    <dbReference type="KEGG" id="clg:Calag_0193"/>
    <dbReference type="eggNOG" id="arCOG00754">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_680815_0_0_2"/>
    <dbReference type="OMA" id="VPNWINI"/>
    <dbReference type="OrthoDB" id="42071at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="397" mass="44608" checksum="3F2E571C5812B88D" modified="2013-03-06" version="1">MYVDIAIVGGGIAGLSVAMELSKYNIDVAVIEKNNDVGLETTSTNHNLICQGADSLSFRPGTLHAELNIKSIPLWPKLSKNLNFKFKRIGGIWLIRDKVDYQKFLKLKSRSFKQSTKPDAPYYIPKEDFTPVEFIDRKTVLDMEPYINKDILGALYDPNLATVDPKEVAKAYAENANYNGVKFLLNTEVKMIRREGIGFSIETNNGNIKASFVINAAGINIDRIADFVKAKNFSYVPLKGTITDFDEEIGKMINHEVHVLPRNEAPNMVTALPTIHGNFRSGIYMELTYRSNNEVTKYAVDYNINVAKKLFPDINFENHIIKSFTGFMAYTNPDTGWHDFVIDIPEYVPNWINILLGPAGVSASPMIGKYVVELIKNTGFKIEEKSNYSPTGRKVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A846</accession>
    <name>L0A846_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type polysaccharide/polyol phosphate export systems, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231941.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0262"/>
    <dbReference type="EnsemblBacteria" id="AFZ70043">
        <property type="protein sequence ID" value="AFZ70043"/>
        <property type="gene ID" value="Calag_0262"/>
    </dbReference>
    <dbReference type="GeneID" id="14211522"/>
    <dbReference type="KEGG" id="clg:Calag_0262"/>
    <dbReference type="eggNOG" id="arCOG01467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_6_0_2"/>
    <dbReference type="OMA" id="AWIFKTG"/>
    <dbReference type="OrthoDB" id="77595at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="20"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="260" mass="29236" checksum="B2F1E8D547E31121" modified="2013-03-06" version="1">MAYPKIIRLIIRNIMVNSDPGTWLILVGMPAMFLIFFSYGYGSMLSSMGLSYISYAKFLAPGMLAYETLIAGTATGSMLWFDRRWGSLAQILAMPFTRTDYLLGLILSTVIFAIMGNAVLIIISYFIIPGLTFSILGLLIMVSVLIIGSLLFGSFMLILASYIKSQNAYNSIQILIIFLINFASTVFYPASSLPKILEYIFYLNPLTYIANLMRDGFLKTIKPTDISIIDIYELIGLIILSILLILIARYSYMRSEIRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A855</accession>
    <name>L0A855_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chloride channel protein EriC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0273</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0273"/>
    <dbReference type="EnsemblBacteria" id="AFZ70053">
        <property type="protein sequence ID" value="AFZ70053"/>
        <property type="gene ID" value="Calag_0273"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0273"/>
    <dbReference type="eggNOG" id="arCOG02569">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015263_5_3_2"/>
    <dbReference type="OMA" id="PMISGSG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="459"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="578" mass="62955" checksum="962A0540E3A9024D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A889</accession>
    <name>L0A889_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0304"/>
    <dbReference type="EnsemblBacteria" id="AFZ70083">
        <property type="protein sequence ID" value="AFZ70083"/>
        <property type="gene ID" value="Calag_0304"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0304"/>
    <dbReference type="eggNOG" id="arCOG10655">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_786821_0_0_2"/>
    <dbReference type="OMA" id="RWPEVEF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039065">
        <property type="entry name" value="AcoX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40697">
        <property type="entry name" value="PTHR40697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="329" mass="36260" checksum="22D1A74B4F72D984" modified="2013-03-06" version="1">MNIMPGPVGIIINPNSGTDARRLTSNAQFMDSIQKLRIIKSVIMGLISTGINDIAVMPDYLGIAYNLIRDLKIEGVDLSIIDIDPEGDFNDTKNSIKIFRKENSPLIILLGGDGTIRAAAEESIDIPYLPLSTGTNNTIPYLVEGTVAGLAAGYFINYNIKEGLCNLNKIDIYINKEFKSIALVDVSTTNYKYKGTGIIDLSMIIDSVVIYGKPTSIGLASIGGLIYDMGCNSSKFVYINFNGNKYKIKAIASPGVVKNIDINYYKIVDVGNKILMEKSFFIEADGERLYPVDYEDEVISYVNPNGPKILDINKIMEFISKNQLFKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8K4</accession>
    <name>L0A8K4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable Brix domain-containing ribosomal biogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably involved in the biogenesis of the ribosome.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232096.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0430"/>
    <dbReference type="EnsemblBacteria" id="AFZ70198">
        <property type="protein sequence ID" value="AFZ70198"/>
        <property type="gene ID" value="Calag_0430"/>
    </dbReference>
    <dbReference type="GeneID" id="14211690"/>
    <dbReference type="KEGG" id="clg:Calag_0430"/>
    <dbReference type="eggNOG" id="arCOG03247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118422_0_0_2"/>
    <dbReference type="OrthoDB" id="61656at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00699">
        <property type="entry name" value="BriX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023548">
        <property type="entry name" value="Brix_dom_Rbsml_bgen_prot"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Brix" evidence="3">
        <location>
            <begin position="17"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="202" mass="23365" checksum="3877416834345D92" modified="2013-03-06" version="1">MPSVPLRFEKIYNKNKSSILLTSSRDPSTRTRTFINELSSVLPKSIKIGRGKLSLEELNQIILRYNIPKLIVINEYKGNPGKIQLFKPNENSKRPDLILYAIIYGVSLRKELGFNKKISVRDAAIKLIDEKQDNVKYDYINKLSTMLDLNVNDRLIDENNIAYFLVKFDFPYIDIKVFNRNVNIGPNFKLKFGDDINDGSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8N1</accession>
    <name>L0A8N1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyruvate-formate lyase-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0461</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232126.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0461"/>
    <dbReference type="EnsemblBacteria" id="AFZ70228">
        <property type="protein sequence ID" value="AFZ70228"/>
        <property type="gene ID" value="Calag_0461"/>
    </dbReference>
    <dbReference type="GeneID" id="14211721"/>
    <dbReference type="KEGG" id="clg:Calag_0461"/>
    <dbReference type="eggNOG" id="arCOG00946">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044176_1_0_2"/>
    <dbReference type="OMA" id="YHFYPGS"/>
    <dbReference type="OrthoDB" id="39920at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="83"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="367" mass="41929" checksum="5DE6B898EF6049B1" modified="2013-03-06" version="1">MVRPESDSARLKSHIRIAKFWTTLNDKQNWVKCNLCHRRCLIAPNAWGVCGVRKNIDGKLYTMVYGLLTAENADPIEKKPLMHFNPGSTVLSISTVGCDFFCAFCQNWEISQSRLEKGLYGERKEPEEIIRDAINIKADGISYTYNEPTIMYEFMYDTASLAKKNDLFNTMVTNGYMTPEAVDDIGNLMDAATVDFKGGGNKEFYRKYMGVPNPEPILETLKAMKDKKIWIEITNLVVPKVGDKDEDIKKLAKWIVENLGDNVPFHLLRFHPDYKMLDSEDTPVKTLERLANIAKNEGLKYVYIGNVPGHQMEHTYCPKCGYPLIERYGFYITAWRLTDDNRCPRCGTKIDIVGKKRSSSPFSLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8N6</accession>
    <name>L0A8N6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232131.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0467"/>
    <dbReference type="EnsemblBacteria" id="AFZ70233">
        <property type="protein sequence ID" value="AFZ70233"/>
        <property type="gene ID" value="Calag_0467"/>
    </dbReference>
    <dbReference type="GeneID" id="14211727"/>
    <dbReference type="KEGG" id="clg:Calag_0467"/>
    <dbReference type="eggNOG" id="arCOG04312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107892_0_0_2"/>
    <dbReference type="OMA" id="SWRIDVE"/>
    <dbReference type="OrthoDB" id="118267at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041120">
        <property type="entry name" value="PIN_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18477">
        <property type="entry name" value="PIN_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="138" mass="15999" checksum="517B18F12ED680FA" modified="2013-03-06" version="1">MTKVILDSNMIIMLGKGIITISMFEDLLEQKFNLITTSSVIDELKKISEQNKNRIININIKFGLNIIKNKVEIIETKNVTDADDSIFYTSLDLKNKGEVVFVATNDRELRSRLRIAKIPTIYYRDSKSKLELEWKELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Q1</accession>
    <name>L0A8Q1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232114.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0449"/>
    <dbReference type="EnsemblBacteria" id="AFZ70216">
        <property type="protein sequence ID" value="AFZ70216"/>
        <property type="gene ID" value="Calag_0449"/>
    </dbReference>
    <dbReference type="GeneID" id="14211709"/>
    <dbReference type="KEGG" id="clg:Calag_0449"/>
    <dbReference type="eggNOG" id="arCOG01354">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2475826_0_0_2"/>
    <dbReference type="OMA" id="CHSPRRI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="87" mass="9793" checksum="B6CE13A998E56999" modified="2013-03-06" version="1">MDKDSVECTAELVIPNKDANAIAKSLTPDNIKDLPSYLDISCKNENDKLICTIRIKDCKDPKRIMSLKNTLDDLLINIRSIIDSMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Q5</accession>
    <name>L0A8Q5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0454"/>
    <dbReference type="EnsemblBacteria" id="AFZ70221">
        <property type="protein sequence ID" value="AFZ70221"/>
        <property type="gene ID" value="Calag_0454"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0454"/>
    <dbReference type="eggNOG" id="arCOG05957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2140081_0_0_2"/>
    <dbReference type="OMA" id="CEETLYG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="112" mass="12972" checksum="6E3A672F4C59BBBE" modified="2013-03-06" version="1">MLSQKEMMKRKIESLISILRQKGLKVSSIEDKNTCFYSVSEYKNKIFALFFYIPKYSNYIITKLTVTIGGCEETLYGANGLFILEENESTLAEKIIEKLEYMKKVNFNADLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8V6</accession>
    <name>L0A8V6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231752.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0063"/>
    <dbReference type="EnsemblBacteria" id="AFZ69854">
        <property type="protein sequence ID" value="AFZ69854"/>
        <property type="gene ID" value="Calag_0063"/>
    </dbReference>
    <dbReference type="GeneID" id="14211323"/>
    <dbReference type="KEGG" id="clg:Calag_0063"/>
    <dbReference type="eggNOG" id="arCOG01987">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049557_0_0_2"/>
    <dbReference type="OMA" id="YDPWFAK"/>
    <dbReference type="OrthoDB" id="59951at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="274" mass="30858" checksum="0F9403E003A0B92D" modified="2013-03-06" version="1">MPTSKIMNLNEAVDLINNGDLITISGITFFRNPMSFISALIKSDKKDLSFVDREPGFGLDVLTASNKLKMIRAAMATFEHFGLSPNVRKAAERKQVDYLEDTCGAIIAGFRAGAQGVPFMPVRGIIGSDLVNIHEKRGTWKIIKDPFTNEDIAIIKAIEPDVAIIHVHMSDEYGNSVILGPRYEDELKIRAAKKVIITAERIVDKEELKKRNTEQLSSTSIHVDAVIHSKNGAWPTGMYTMYEADYKAINEYYNYAKDGKAIEWINNNLLKRWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A923</accession>
    <name>L0A923_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232264.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0609"/>
    <dbReference type="EnsemblBacteria" id="AFZ70366">
        <property type="protein sequence ID" value="AFZ70366"/>
        <property type="gene ID" value="Calag_0609"/>
    </dbReference>
    <dbReference type="GeneID" id="25396755"/>
    <dbReference type="KEGG" id="clg:Calag_0609"/>
    <dbReference type="eggNOG" id="arCOG00054">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057700_0_0_2"/>
    <dbReference type="OMA" id="LDTCMGL"/>
    <dbReference type="OrthoDB" id="75744at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="286" mass="33080" checksum="A98D736E64E20DD8" modified="2013-03-06" version="1">MEIFEFEPFKGIALLPKESKSIIKNEQATINCGRDRADYINKENDKIIIKFNEKIFEIDYDVLEKHVNRRSVLLIDKDYYEAEVRSTNNYYKLVPVNDTYYTTLEINGIHMHRIKGITPMEDAKRKVEVAAVRKGVRVLEIGTGLGYTAINSLKFGAREVITIEKDQNVLWLAERNPWSYELNSEKIKIILGNAFDIIKDFNNEFDIIIHDPPRFTSNSSELYSIEFYKYLYSALKRNGVLFHYTGEPGRVKGKGFPLKISGKLKDVGFEVLRYDSIAMGIKAIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A928</accession>
    <name>L0A928_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="L0A928"/>
    <dbReference type="STRING" id="1056495.Calag_0142"/>
    <dbReference type="EnsemblBacteria" id="AFZ69929">
        <property type="protein sequence ID" value="AFZ69929"/>
        <property type="gene ID" value="Calag_0142"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0142"/>
    <dbReference type="eggNOG" id="arCOG02638">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_4_2"/>
    <dbReference type="OMA" id="LWYPSTM"/>
    <dbReference type="OrthoDB" id="65084at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="107"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="330" mass="37580" checksum="EF17F34C019B6463" modified="2013-03-06" version="1">MLNYISLFLYINVYKIFYTYSLYINLVEIMPIDINLEKWLSQLPKEVFTPRNVEEFRKYMDEGSNIIKQFAPKIEMKEIRNEFINGRESKIPVRIYIPKIVETQGILIYLHGGGFVWGSSDSYDHVLRYLANECKCKVASIDYRLAPEHKFPAAVIDSFDSVKYFYEKEKSVAIAGDSAGGNLSAVSSILARDEGIKLKASVLIYPTVGYDATSKSMREYSNIFLTREAMNFFGLMYLKSPTDIYDIRFSPILAESHKNLPPTLIITAEYDPLRDQGETYASILNRSGVETIQIRFGGVTHGFINLLGIVPSAEVTLQTISSFIRSKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0A929</accession>
    <name>L0A929_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aconitate hydratase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0646</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232296.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0646"/>
    <dbReference type="EnsemblBacteria" id="AFZ70398">
        <property type="protein sequence ID" value="AFZ70398"/>
        <property type="gene ID" value="Calag_0646"/>
    </dbReference>
    <dbReference type="GeneID" id="14211906"/>
    <dbReference type="KEGG" id="clg:Calag_0646"/>
    <dbReference type="eggNOG" id="arCOG01697">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013476_2_1_2"/>
    <dbReference type="OMA" id="NGGIMQY"/>
    <dbReference type="OrthoDB" id="2260at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="6">
        <location>
            <begin position="82"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="7">
        <location>
            <begin position="696"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="900" mass="100608" checksum="2F10064C5B0600BC" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0A947</accession>
    <name>L0A947_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="9">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rtcB</name>
        <name evidence="10" type="ordered locus">Calag_0669</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 9">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0669"/>
    <dbReference type="EnsemblBacteria" id="AFZ70418">
        <property type="protein sequence ID" value="AFZ70418"/>
        <property type="gene ID" value="Calag_0669"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0669"/>
    <dbReference type="eggNOG" id="arCOG04246">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022279_0_1_2"/>
    <dbReference type="OMA" id="QTRGVEC"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="6">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="329"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="378"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="480" mass="52957" checksum="D22541E0FB38FCDC" modified="2013-03-06" version="1" precursor="true">MPGIEPKKIGDHTWMIEKTGCMKVPSIIYADDVLIEKMKQDMTLNQSINVACLQGIQKYSLVMPDGHQGYGFPIGGVAAMAIDENGVISPGGVGYDINCGVRLIRTSLSLKDVLPKIKDLINIIYDNVPSGLGSTGKLKLTNAELDNILNYGAKWAVEKGYGWEKDIDFIEENGAWKLADASKVSNAARKRGSNELGTLGSGNHFLEVQYVDKVFDEKLAKAFGIFENQVTIMIHTGSRGLGHQVASDYLQIMERAMRRYNTIPPDRELASIPYNSPEAQDYVRAMASAANYAWANRQIIMHWTRESFAQVFKTDPENLGMDLVYDVAHNIAKIEEYDIDGKRKKVVVHRKGATRAFPPGNKEIPSKYRDYGQPVLIPGSMGTASYILAGVETGVKSWFTAPHGAGRWMSRSSAKRERSYKEVVDELNKKGIYLKASNVATVIEEMPEAYKNVDNVAETAAAVGIAKLVARMRPIGVTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0A952</accession>
    <name>L0A952_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232294.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70396">
        <property type="protein sequence ID" value="AFZ70396"/>
        <property type="gene ID" value="Calag_0643"/>
    </dbReference>
    <dbReference type="GeneID" id="14211903"/>
    <dbReference type="KEGG" id="clg:Calag_0643"/>
    <dbReference type="HOGENOM" id="CLU_2613410_0_0_2"/>
    <dbReference type="OMA" id="LGVKWFE"/>
    <dbReference type="OrthoDB" id="2692at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="78" mass="9833" checksum="BAD9B1C315771D6D" modified="2013-03-06" version="1">MVENYIEELEDEKSRNLEEIIHHARWEAEMVRRLGVKWFEIRDKWLWESLEADLEFWRKNPRVRKALLETLKLNYEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A963</accession>
    <name>L0A963_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231862.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0179"/>
    <dbReference type="EnsemblBacteria" id="AFZ69964">
        <property type="protein sequence ID" value="AFZ69964"/>
        <property type="gene ID" value="Calag_0179"/>
    </dbReference>
    <dbReference type="GeneID" id="14211439"/>
    <dbReference type="KEGG" id="clg:Calag_0179"/>
    <dbReference type="eggNOG" id="arCOG03649">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_20_3_2"/>
    <dbReference type="OMA" id="SRWVWTA"/>
    <dbReference type="OrthoDB" id="47311at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="26"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ69964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="468" mass="51651" checksum="F0F830D421FDD138" modified="2013-03-06" version="1">MESEDKLLSQRSKDLKKGVVTYAELIFQSISFTAPAIAVTATMTGAAAFAYGSLPLTYILALFGILSAGFVVYSFSRKVASSGGYYRYIERGLGPRLGAFGGWTYILYTVIGATPFIYFETALAIQYGLQAFGINVPSWFWYPIGLIVGILAFLLAYSGIKNSLRYSLYTGTAEILLLIIVAIVILIRTPTPFNLKVFTPAYSPTGWNGVALGMVFSFTSLAGWGSMVFLGAEARQAHYNIRRGVTLTILILGLLFLFESYAMTIGWGPQNMSTYFNYFLPGLVLALKDGGIILAAILFIFLINSGFVDTLAIINAGSRDLYTMSKDGLLPDKLSDTHPKYKSPHIALIVNTLVGVILFTITGWLFGPLNGFLITGIWTGTGTLIEHILVNTSLPLYFRKHKELRWTYITIPLISTALYIFAIYGSFLSINYYILIGTFSMVAWLVAGAIIYSFKKNIKIRLEENEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0A983</accession>
    <name>L0A983_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Leucyl aminopeptidase (Aminopeptidase T)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231882.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0202"/>
    <dbReference type="EnsemblBacteria" id="AFZ69984">
        <property type="protein sequence ID" value="AFZ69984"/>
        <property type="gene ID" value="Calag_0202"/>
    </dbReference>
    <dbReference type="GeneID" id="14211462"/>
    <dbReference type="KEGG" id="clg:Calag_0202"/>
    <dbReference type="eggNOG" id="arCOG01890">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062630_0_0_2"/>
    <dbReference type="OMA" id="TCHIDIP"/>
    <dbReference type="OrthoDB" id="38853at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="350" mass="38936" checksum="2FE242522CCA8B3D" modified="2013-03-06" version="1">MTAELSKLSIEVSFSAYKLVKDILKVEPGEEVIITADTRSDMNVVNETAKAVKLLSGKPLIVVFESPPEVGHAAEKYIPVSSLSSLMESPDVWIEFNKSWLLYSKVYEKAISNGKTRYMCLVGMDSDMMVRTIGRVDIKKIFELQNKLAEITKKSSKMRITNPNGMEVTFSNDPERPVLVEGEVNGPGEYMLLGQVDWAPIEDSIEGTIVFDGSVWPPESLGLLKSPIKLHLEKGYIKEIEGGYEAKIYERWLKSLNDRNMFRVAHISYGVNPGAKLTGNILEDERIFGAVEWGLGNQSQTFKGKLGSAISHSDGISLYPTVWVDTTKLIENGNFVHEDLKTIINSLIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A987</accession>
    <name>L0A987_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0718"/>
    <dbReference type="EnsemblBacteria" id="AFZ70463">
        <property type="protein sequence ID" value="AFZ70463"/>
        <property type="gene ID" value="Calag_0718"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0718"/>
    <dbReference type="eggNOG" id="arCOG01072">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040940_5_3_2"/>
    <dbReference type="OMA" id="HIASAKP"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="158" mass="17528" checksum="06DE8F0432DACB24" modified="2013-03-06" version="1">MDAAVLVLLFGTPPRVLMVRKNCLVSGRFSCDLAFPGGHIKKGETYIDAALREAWEEANVFPKFVKILGVMDVHETASKPVVKVLPVIGALNGPIDAKPKDTEVDYVIWIPLDSIGEPRLVFHPIRGYVYGYTLPGNLVIWGLSYRIINDLKSKFCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A988</accession>
    <name>L0A988_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitro_FeMo-Co domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232334.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0691"/>
    <dbReference type="EnsemblBacteria" id="AFZ70436">
        <property type="protein sequence ID" value="AFZ70436"/>
        <property type="gene ID" value="Calag_0691"/>
    </dbReference>
    <dbReference type="GeneID" id="14211951"/>
    <dbReference type="KEGG" id="clg:Calag_0691"/>
    <dbReference type="eggNOG" id="arCOG02734">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104194_3_1_2"/>
    <dbReference type="OMA" id="HHEDNET"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="1">
        <location>
            <begin position="15"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="132" mass="15279" checksum="33FF1EF9F6885FA8" modified="2013-03-06" version="1">MSENKIIKIAIPSDDGESMSDHFGRSLGFIVYYVDLTDKKVLNKEFRKRSIVENNEEHHHEHHHHEDNETSVEEARRHLDILNTIKDVDIIITAGIGPRMLSAFRSLNKQVIIGYDINPDNLVKEFMDQNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9D9</accession>
    <name>L0A9D9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232410.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70513">
        <property type="protein sequence ID" value="AFZ70513"/>
        <property type="gene ID" value="Calag_0770"/>
    </dbReference>
    <dbReference type="GeneID" id="14212030"/>
    <dbReference type="KEGG" id="clg:Calag_0770"/>
    <dbReference type="HOGENOM" id="CLU_2203992_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="107" mass="12322" checksum="BCF63CD179A98260" modified="2013-03-06" version="1">MTCYIDLDNVNDLDEISDELNDFAEDISTIQDYLDEHMGDFIEKLNEALNSEGIVLSCNEAKEGNMECKYKFQSDLIGGEVIFLVEIDPFDNKIKDYDIDKIRLITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9G5</accession>
    <name>L0A9G5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232408.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0768"/>
    <dbReference type="EnsemblBacteria" id="AFZ70511">
        <property type="protein sequence ID" value="AFZ70511"/>
        <property type="gene ID" value="Calag_0768"/>
    </dbReference>
    <dbReference type="GeneID" id="14212028"/>
    <dbReference type="KEGG" id="clg:Calag_0768"/>
    <dbReference type="eggNOG" id="arCOG02037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1122579_0_0_2"/>
    <dbReference type="OMA" id="PANDEPM"/>
    <dbReference type="OrthoDB" id="72347at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="247" mass="28115" checksum="8D6934531E1232F6" modified="2013-03-06" version="1">MSENREEVIERLRKSLDLTLYEAKLYLALLEGAKDPKDASAKSGVPLPRIYDVIKVLEAKGMAVSDPKGWYRAVHPRAVAVSAIARLEEDSKKKIKEILNIADSLESFAISENNESIIIVKGYYNLLSLLAENMKDTDIAYITTSRVLNNWEESLKPLVKSIIMLVNEIRIFVEEFNEFNKGLNEEGKEMRILTKIYKPILYDLISSKKSYIIILKGPEGLISVVNQGQLEAREVFDRLNLIWKLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9P5</accession>
    <name>L0A9P5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Calag_0845</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232483.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0845"/>
    <dbReference type="EnsemblBacteria" id="AFZ70586">
        <property type="protein sequence ID" value="AFZ70586"/>
        <property type="gene ID" value="Calag_0845"/>
    </dbReference>
    <dbReference type="GeneID" id="14212105"/>
    <dbReference type="KEGG" id="clg:Calag_0845"/>
    <dbReference type="eggNOG" id="arCOG03749">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141437_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="VKc" evidence="11">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="157" mass="17978" checksum="DDB821F5C4EE793F" modified="2013-03-06" version="1">MEKNKVFLIFFLISIIGIITSSISFYYVYKANSSPPACYFSGNLSQTSISLDCLKVLKSSYSSLQIKIGNIVIKENLDILAMIYFSIGLIFSLLVLIKYSIIGELIWSIIGFLFVPYLIYLEIYKIRSICIYCTTMHILIISQLILSIYFFIKLSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9R4</accession>
    <name>L0A9R4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="10">IGPS</shortName>
            <ecNumber evidence="4 10">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trpC</name>
        <name evidence="13" type="ordered locus">Calag_0099</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="4 10"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231785.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0099"/>
    <dbReference type="EnsemblBacteria" id="AFZ69887">
        <property type="protein sequence ID" value="AFZ69887"/>
        <property type="gene ID" value="Calag_0099"/>
    </dbReference>
    <dbReference type="GeneID" id="14211359"/>
    <dbReference type="KEGG" id="clg:Calag_0099"/>
    <dbReference type="eggNOG" id="arCOG01088">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034247_0_1_2"/>
    <dbReference type="OMA" id="RGPHDLI"/>
    <dbReference type="OrthoDB" id="98284at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_A">
        <property type="entry name" value="IGPS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="12">
        <location>
            <begin position="11"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ69887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="242" mass="27877" checksum="D5CFFE2B5A8E285D" modified="2013-03-06" version="1">MNWLEEVIENSKNRIKVKNERKKKINSLKESLINLQQKGVTPIIAEYKRKSPSGFISDKDYHNYINFLENYVAGFSVLTEEKYFGGSYEILESISEITNKPILMKDFIVTKDQIDNAFRIGADAILLIASILNEDLLDQLINYARSYRLETLVEIHTYEEFEKIKSFKFDLLGINSRNLFTLNVSLDNTIKLLRNIKGDYIKIAESGIKSKEDILKLKDNGANGFLIGTTLMKNPLIIRELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9T0</accession>
    <name>L0A9T0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent thymidylate synthase</fullName>
            <shortName evidence="1">FDTS</shortName>
            <ecNumber evidence="1">2.1.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FAD-dependent thymidylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thymidylate synthase ThyX</fullName>
            <shortName evidence="1">TS</shortName>
            <shortName evidence="1">TSase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thyX</name>
        <name evidence="2" type="ordered locus">Calag_0404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:29043"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.148"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate synthase ThyX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.148" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232072.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0404"/>
    <dbReference type="EnsemblBacteria" id="AFZ70174">
        <property type="protein sequence ID" value="AFZ70174"/>
        <property type="gene ID" value="Calag_0404"/>
    </dbReference>
    <dbReference type="GeneID" id="14211664"/>
    <dbReference type="KEGG" id="clg:Calag_0404"/>
    <dbReference type="eggNOG" id="arCOG01883">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077585_0_0_2"/>
    <dbReference type="OMA" id="ESTRYCN"/>
    <dbReference type="OrthoDB" id="77034at2157"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01408">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Involved in ionization of N3 of dUMP, leading to its activation" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="83"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="311" mass="36023" checksum="8A01EE3781F13255" modified="2013-03-06" version="1">MEEKLNLNIKVTLVEYTKASPKIIASASKMSTSRKKVEDLLEINKEEIDTWIKETFKRNHFSPWEHSSYTFMIEGCSRVCSHQLVRHRIASFTQQSMRYTEASLREMALYMASKLKMDCPNKPKKGDRDAYKCYSKALKDSINALEPDELIKVANVAYVFPPLMKKDRALIYANSLIDATANYYQLLSTGLSKEDARFIIPMSVRTKITVTMNARELIQTFFPLRMCTRAQWEIRKVAWLLWVELMKIHPELFKYAGPSCVHLENINRDEPDTLQNFIDGKSLFTINRCPELVKNSGIRPCLLNAYNTLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9V3</accession>
    <name>L0A9V3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate thymidylylransferase, long form</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232570.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0942"/>
    <dbReference type="EnsemblBacteria" id="AFZ70673">
        <property type="protein sequence ID" value="AFZ70673"/>
        <property type="gene ID" value="Calag_0942"/>
    </dbReference>
    <dbReference type="GeneID" id="14212202"/>
    <dbReference type="KEGG" id="clg:Calag_0942"/>
    <dbReference type="eggNOG" id="arCOG00667">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_1_2"/>
    <dbReference type="OMA" id="FTWLDTG"/>
    <dbReference type="OrthoDB" id="61185at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04189">
        <property type="entry name" value="G1P_TT_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005908">
        <property type="entry name" value="G1P_thy_trans_l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01208">
        <property type="entry name" value="rmlA_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="353" mass="39551" checksum="4441389273A0ECC6" modified="2013-03-06" version="1">MKGIILHGGKGTRLRPLTFSGPKQLIPIANKPISHHVLDDLLNAGIKDIAIVLGNTYPESVVNYYKDGKQFNANITYIYQGEALGIAHAVLMAEEFVNEEPFIVYLGDNLLQYGISKYRKEFEENDYDAMVLLKEVDDPRSFGVAIVKDNKIIDLIEKPKEFISKLALTGIYFLKPSIFNIIKGLKPSKRGELEITDALSTMLKKGYKLGFSIVDGWWLDTGKKDDIILANQLILDEKIQKKISNSAIITNSNIGGRVEIDEKTIIENSIIRGPLIIGKNSEIRNSFIGSYTSVGNNVKIVNSEIENSIILDNTIIENVKRIEDSLIGRNSKIKENSRKVIKLHVSDYSEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9V6</accession>
    <name>L0A9V6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Proteasome core protein PsmA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">psmA</name>
        <name evidence="5" type="ordered locus">Calag_0436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232102.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0436"/>
    <dbReference type="EnsemblBacteria" id="AFZ70204">
        <property type="protein sequence ID" value="AFZ70204"/>
        <property type="gene ID" value="Calag_0436"/>
    </dbReference>
    <dbReference type="GeneID" id="14211696"/>
    <dbReference type="KEGG" id="clg:Calag_0436"/>
    <dbReference type="eggNOG" id="arCOG00971">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_2"/>
    <dbReference type="OMA" id="FQVEYAR"/>
    <dbReference type="OrthoDB" id="57654at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03756">
        <property type="entry name" value="proteasome_alpha_archeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_A">
        <property type="entry name" value="Proteasome_A_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019982">
        <property type="entry name" value="Proteasome_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03633">
        <property type="entry name" value="arc_protsome_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="4">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="254" mass="28306" checksum="E790AC7A2941F8C7" modified="2013-03-06" version="1">MAAPPSAYDRAITIFSPDGELYQVRYAFEAVKKGWTSLGIITDQGVILAAEKRRMLPLLDLEGIEKIYKVDDHIGVTFAGMGSDGRVLIDYARQVSIRHRLTYGEAPTVEYITKSVADIKQAYTQHGGFRPFGVALIFGGVNNDNIPRLYRTEPGGQYFSYYAVAIGLGGDVANNYMEKQYNKNMSLSDAIELAVKALFKSRVSTSDENKNDLINNFGQYVEIAYIDVKQKMFSRVSEKEINDIVADNKGELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9X1</accession>
    <name>L0A9X1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="4" type="ordered locus">Calag_0452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0452"/>
    <dbReference type="EnsemblBacteria" id="AFZ70219">
        <property type="protein sequence ID" value="AFZ70219"/>
        <property type="gene ID" value="Calag_0452"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0452"/>
    <dbReference type="eggNOG" id="arCOG04313">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_2"/>
    <dbReference type="OMA" id="KIVAMKM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="3">
        <location>
            <begin position="6"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="145" mass="16336" checksum="3328D959864A50F1" modified="2013-03-06" version="1">MTIRMTERTLVLVKPDGVKRGLIGEVISRFEKKGLKLVALKMVKFDRTKGEEFYSVHKDKSFFSDLVNFITSGPIVAMILEGDSAISVVRLMIGSTDGRKAQPGTIRGDFALSIQDNVVHASDSQESFEREYKVIFRDEEIISNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Y1</accession>
    <name>L0A9Y1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0930"/>
    <dbReference type="EnsemblBacteria" id="AFZ70661">
        <property type="protein sequence ID" value="AFZ70661"/>
        <property type="gene ID" value="Calag_0930"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0930"/>
    <dbReference type="eggNOG" id="arCOG02487">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_439173_0_0_2"/>
    <dbReference type="OMA" id="MRVIYLA"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="509"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="622" mass="72108" checksum="4A954F77BB55E13F" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA17</accession>
    <name>L0AA17_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0107"/>
    <dbReference type="EnsemblBacteria" id="AFZ69895">
        <property type="protein sequence ID" value="AFZ69895"/>
        <property type="gene ID" value="Calag_0107"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0107"/>
    <dbReference type="eggNOG" id="arCOG01051">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_1_2"/>
    <dbReference type="OMA" id="VINTCDY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="4">
        <location>
            <begin position="8"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ69895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="315" mass="35419" checksum="0CFA2786DDF6E052" modified="2013-03-06" version="1">MVKMNLNYSYRESLGKALVKIGEKKKEVVVVDSDVSKSTYTKYFAEKFPNRFVSVGISEQDLIGFSAGLALGGKIPIAVAFSMFLMRAWEQIRNTIARDKLNVKIIGTHSGLSDFLDGSSHQALEDISLIRILPNFTVVAPSDIVSTEKLVYEMVDHIGPVYMRIGRDNSPKIYDDQEEFKIGKSKTLIEGDDILIISYGPMVEISREVVNLLRKKGFSSSLIDLYSIKPFDEQNVIKLAYKSNLIAIIEEHNVNGGVGDMISSFLSSRLPRKVVKIGIEDSFGTSARNYLELIEFFKLTPKNIEERLKVIYDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA18</accession>
    <name>L0AA18_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232598.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0978"/>
    <dbReference type="EnsemblBacteria" id="AFZ70701">
        <property type="protein sequence ID" value="AFZ70701"/>
        <property type="gene ID" value="Calag_0978"/>
    </dbReference>
    <dbReference type="GeneID" id="14212238"/>
    <dbReference type="KEGG" id="clg:Calag_0978"/>
    <dbReference type="eggNOG" id="arCOG03837">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1036687_0_0_2"/>
    <dbReference type="OMA" id="EGRENTY"/>
    <dbReference type="OrthoDB" id="128923at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="280" mass="32198" checksum="D81F91928B17BC7E" modified="2013-03-06" version="1">MPAKFFINEKNIKFNESQAFNEELIGNLFKEPGSTYLFLTHLKDDGNSIGLYYKYEGRENTYRRITGGPKIDFYENYVYLSILTNRVETLKKVNERAKLFSKCISGTEIYGGLSISRDKKLAYGITKIGNISVIEIITNNNLNDIKYCLKSNINNVNEEMINVIPNKYSSDSYLKKSWISYGNKDYEFNSSSRNEGFYVNFSAKLLENYIDKVLITGNFYASPPMEPITSILALEGTPVNEVYFYGIKARIKKIEIEGIKTENILFSIDDLYNKLIKSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA28</accession>
    <name>L0AA28_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231803.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0117"/>
    <dbReference type="EnsemblBacteria" id="AFZ69905">
        <property type="protein sequence ID" value="AFZ69905"/>
        <property type="gene ID" value="Calag_0117"/>
    </dbReference>
    <dbReference type="GeneID" id="14211377"/>
    <dbReference type="KEGG" id="clg:Calag_0117"/>
    <dbReference type="eggNOG" id="arCOG00861">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_6_3_2"/>
    <dbReference type="OMA" id="IPPRQAH"/>
    <dbReference type="OrthoDB" id="20371at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="363" mass="41763" checksum="8F39B34E2433E50E" modified="2013-03-06" version="1">MKYDVLKIGGSILSTPKSYIDVSMYIKKFVEKNKRLIIVVSALKGMTDLLIDFYDNNNKNALDKFIEKYQDVVFYFDNQELKYKFNSLINELLNIAKNGRNHDLKIRDKILSYGEKISKLILFYALKINDLNATPLNADDIIITDNRYGDAFIDLDKTSNNLHLNEDIYLIEGFIGRSYENYITTLGRGGSDYTASVLSYLINADNLYLITDVPGIYSSDPRIVKNVKIVKRLNFEEAIEASTYNVKGINYKTFYPLINSKINVYIGTFDNFNTIINSKPLYNEHVKLFGLKHANEIKSIGLIGYGMNKDFIIKRIYNLFDGNHNDIMINKNGEKPSMHINVKTDDFHNFVNLLHDELIGDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA31</accession>
    <name>L0AA31_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate dehydrogenase and fumarate reductase iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232613.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0993"/>
    <dbReference type="EnsemblBacteria" id="AFZ70716">
        <property type="protein sequence ID" value="AFZ70716"/>
        <property type="gene ID" value="Calag_0993"/>
    </dbReference>
    <dbReference type="GeneID" id="14212253"/>
    <dbReference type="KEGG" id="clg:Calag_0993"/>
    <dbReference type="eggNOG" id="arCOG00962">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_3_2_2"/>
    <dbReference type="OMA" id="CTHCYRC"/>
    <dbReference type="OrthoDB" id="88832at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="253" mass="28735" checksum="CFEC0DD74782B213" modified="2013-03-06" version="1">MNGNKNRTVKLKIKRYLPDKGEIKEFSYEVKVNKYTTVLDALINVKETQDPSIAIRYSCRMGICGSCGMVIDGKPRLACQTHIETLKKDEVVVGPMEGHPILKDLVTDMDEFFSKHKYVIPWIYTDDIEEKFNPKVEYKQDRRELDYYLPFSYCIKCGLCVDACPISNSNPAFLGPQALAQAYRYNSDSRDKGEKLRLVRIDTPDGVWGCEFIGACSEVCPIGVDPALAIQLLKLDVMRFSLTGKVNNEKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA51</accession>
    <name>L0AA51_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231823.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0137"/>
    <dbReference type="EnsemblBacteria" id="AFZ69925">
        <property type="protein sequence ID" value="AFZ69925"/>
        <property type="gene ID" value="Calag_0137"/>
    </dbReference>
    <dbReference type="GeneID" id="14211397"/>
    <dbReference type="KEGG" id="clg:Calag_0137"/>
    <dbReference type="eggNOG" id="arCOG04284">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075503_0_1_2"/>
    <dbReference type="OMA" id="GAPFWEG"/>
    <dbReference type="OrthoDB" id="84563at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990397">
        <property type="term" value="P:queuosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003744">
        <property type="entry name" value="YhhQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34300">
        <property type="entry name" value="PTHR34300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02592">
        <property type="entry name" value="Vut_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00697">
        <property type="entry name" value="TIGR00697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="273" mass="31141" checksum="D1A56F321A209379" modified="2013-03-06" version="1">MLNFYIYSSNFQEAIIEMGAAMNTMILTWIFWIIGDAISTIFGAYIVKKYRNNYGLPTLIVLYSIYSVGANILASRITIYNIVIPFVVSGGTLIFPFVSQLDDMINEVYGRKRAYATIAVALIANILMATFILADAVLPVPSWEENANKYWLQFMVAAPRIMLASYLAFIVDELWNATIFAKLKSRAYKDEEAWKSNRKIVYLVLTRVFTSDISTMIIDSVVFYPIAFLGTLPANVVLNMIWMGALMKVILAIFNGPWYILYRILIKDVKREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA70</accession>
    <name>L0AA70_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nucleic-acid-binding protein containing a Zn-ribbon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232658.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1039"/>
    <dbReference type="EnsemblBacteria" id="AFZ70761">
        <property type="protein sequence ID" value="AFZ70761"/>
        <property type="gene ID" value="Calag_1039"/>
    </dbReference>
    <dbReference type="GeneID" id="14212299"/>
    <dbReference type="KEGG" id="clg:Calag_1039"/>
    <dbReference type="eggNOG" id="arCOG01283">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119412_2_1_2"/>
    <dbReference type="OMA" id="GYLTYEF"/>
    <dbReference type="OrthoDB" id="120594at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="179" mass="20353" checksum="ADA435311E1862D3" modified="2013-03-06" version="1">MPKSQKEEAIESLKQLEAFANNMKSSIGVPMIVDPKTNVAIWYDQRELNLKFMVSIEKTRKFFESLSEGKLLATKCVKTGEILFPPQVDCPSSPGSEVEWVELPKDGELITYTIITTKPFSFSHYNDYTVGIAKLSNGVQVLAWVRETDPKKLRIGMKVKLEITKREPEGYLTYEFVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA83</accession>
    <name>L0AA83_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231930.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0250"/>
    <dbReference type="EnsemblBacteria" id="AFZ70032">
        <property type="protein sequence ID" value="AFZ70032"/>
        <property type="gene ID" value="Calag_0250"/>
    </dbReference>
    <dbReference type="GeneID" id="14211510"/>
    <dbReference type="KEGG" id="clg:Calag_0250"/>
    <dbReference type="eggNOG" id="arCOG00332">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023081_2_1_2"/>
    <dbReference type="OMA" id="VVIHDSC"/>
    <dbReference type="OrthoDB" id="34668at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="213"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="316" mass="36097" checksum="92FDA3C8680F841E" modified="2013-03-06" version="1">MDGNDIMELLGEITIKTGFPVPINKTKIFEWTNTINMERKGDVYLYTGALYQLIPYINYTVKFLDAISKLSGGDSLINLAKTIIKVSPYYLSSIIKPDIKEINENNAIVRNIAKLLLKINKNIAYLYEDDIYSGVLLYDMGLDDYFLIHSKKVFQSFKKRNVKKIITIDPHTTHVMREGYPKFIDNFDIEVFNYLELLSNTNIDLGKLDKTLTIHDPCVYSRYENIIDQPRKLLKSMGIRIKEPKRSGKNTFCCGGPLESLSPKFSEDIAKTRMNQLLSESNIIITMCPICKANLSRVKPNDAKLVDISEILSSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA97</accession>
    <name>L0AA97_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">o-succinylbenzoate synthase</fullName>
            <shortName evidence="3">OSB synthase</shortName>
            <shortName evidence="3">OSBS</shortName>
            <ecNumber evidence="2 3">4.2.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">4-(2'-carboxyphenyl)-4-oxybutyric acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">o-succinylbenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menC</name>
        <name evidence="5" type="ordered locus">Calag_0592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10196"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18325"/>
            <dbReference type="ChEBI" id="CHEBI:58689"/>
            <dbReference type="EC" id="4.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.113" evidence="2 3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232247.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0592"/>
    <dbReference type="EnsemblBacteria" id="AFZ70349">
        <property type="protein sequence ID" value="AFZ70349"/>
        <property type="gene ID" value="Calag_0592"/>
    </dbReference>
    <dbReference type="GeneID" id="14211852"/>
    <dbReference type="KEGG" id="clg:Calag_0592"/>
    <dbReference type="eggNOG" id="arCOG01168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_4_4_2"/>
    <dbReference type="OMA" id="CRIINIK"/>
    <dbReference type="OrthoDB" id="62994at2157"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043748">
        <property type="term" value="F:O-succinylbenzoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03317">
        <property type="entry name" value="NAAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01933">
        <property type="entry name" value="MenC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010197">
        <property type="entry name" value="OSB_synthase_MenC_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48073:SF5">
        <property type="entry name" value="PTHR48073:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01928">
        <property type="entry name" value="menC_lowGC/arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="4">
        <location>
            <begin position="143"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="377" mass="43070" checksum="29873E3FB65FC66C" modified="2013-03-06" version="1">MELKKIEIFELWVKLKEDFETSFGKTIERPALLIRLEEKGGEVGWAESVAGEGPWYSYETWETAWHILNDFIIPKVIEEKEIDVDKFNEKVSNIRGHNMAKAGFEMALWDLKAKVEGKPLWRLLGGVNRNISSGVSIGIQKTTDDLVKKVSSFLEKGYKRIKIKIKPGYDLEPVIRLRKEFGEDLPLQVDANSAYKLNDIEIFRKLDNYNLLMIEQPLHWKDLVDHAELARHIKTPICLDESIEDVNDARKAYQLNSAMIINIKPGRVGGFNEVLKIHDFWYKIANRNVWIGGMLETGIGRGHLVSAATLPGVRYPNDISASEKYYEKDIVEPPWKLNKDGTITAPEKPGIGVEVLEDYIIKNSKRSKSYSLSNPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAA4</accession>
    <name>L0AAA4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232735.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1116"/>
    <dbReference type="EnsemblBacteria" id="AFZ70838">
        <property type="protein sequence ID" value="AFZ70838"/>
        <property type="gene ID" value="Calag_1116"/>
    </dbReference>
    <dbReference type="GeneID" id="14212376"/>
    <dbReference type="KEGG" id="clg:Calag_1116"/>
    <dbReference type="eggNOG" id="arCOG01700">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_0_2_2"/>
    <dbReference type="OMA" id="YELTTIM"/>
    <dbReference type="OrthoDB" id="52310at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="305" mass="33428" checksum="5D05832C4BD1B380" modified="2013-03-06" version="1">MSLKDIYLTKSSKNYAGLENNKNSRYEIIGVPFDSSTSYKPGTRFGPDAIRQAASGLESNSYFSDIYLEDIGIIDEGDVGIVIGDINETLNRITGVISDVIQENKIPIMIGGEHTITYGSMRAFKKQGITPCLIVIDAHYDLRDEYLGLKNGHASVMRRSLELLGGTKINYIGVRAYSKEEKNYALSKNNINTIKPSDIYKVGLINAINSVKKFLVDCKHIYLSIDMDGFDPSYAPGVGNPEPGGITNIEGLTIINQIVDERLVGADVVEVSPPYDQGGITSSLAAKLINEIIMKNYISLSKKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAA5</accession>
    <name>L0AAA5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Galactose mutarotase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0272"/>
    <dbReference type="EnsemblBacteria" id="AFZ70052">
        <property type="protein sequence ID" value="AFZ70052"/>
        <property type="gene ID" value="Calag_0272"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0272"/>
    <dbReference type="eggNOG" id="arCOG05361">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052486_1_1_2"/>
    <dbReference type="OMA" id="WAVAVEP"/>
    <dbReference type="OrthoDB" id="68229at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="264" mass="29805" checksum="B350A7CF74CD91C2" modified="2013-03-06" version="1">MIKVLTIKNNKSEAIINEIGAYLEKLTLNGKNILLPGNIINPTHGGMAILIPFANRIKGAEYEFNGKKYFLKKNKEGNAIHGLVLDKKFSILKANKDSVSLSYTLEDEGYPTRLEIEVKYSIGNSNLETEFFITNNGNSNAPLVVGAHPYFLIEGYWKINPKKVKKCLLFNKIPNGEFIYYEIEGNIDYDDCFYIGNMVELSSDNINLQIETTDMPYFQIYTGVKGAVALEPMSGIPDAYHNKIGLYIIKPGEKKYYSFIISLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAA8</accession>
    <name>L0AAA8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase (AAA+ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232257.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0602"/>
    <dbReference type="EnsemblBacteria" id="AFZ70359">
        <property type="protein sequence ID" value="AFZ70359"/>
        <property type="gene ID" value="Calag_0602"/>
    </dbReference>
    <dbReference type="GeneID" id="14211862"/>
    <dbReference type="KEGG" id="clg:Calag_0602"/>
    <dbReference type="eggNOG" id="arCOG03169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061108_0_0_2"/>
    <dbReference type="OMA" id="NYVEIKW"/>
    <dbReference type="OrthoDB" id="56889at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="351" mass="40333" checksum="85EB6DD2B3196697" modified="2013-03-06" version="1">MLFDERPKENKGDLFDREKEIEEIMNNINRPLILITGVRRIGKTSILKVVLNELKIPHFIIDCRNLPPNYSKGNLYSLFSNAISSKLSTFLEILSKIRGISILGNSIELKWKGKEYVTLSDLFDHLNEKRIIIGIDEAQKLRGPLSKEIKDSIAHAYDYDRNLTFILTGSEVGLLHEFLGIENSESPLYGRYYHEITLERFDKDKSELFLRKGFEELRLNVDENVIHGIIEMFDGIPGWLALAGNQFSNNRDLKRVKNIAINVALNEINNLIEMKNNVSPVVARRYRTVMRCIARGTNSWSKIVNCIQKEEGSTISTSVLDNILNNLKKLSIIDENYEFLDPIYKEASILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAC3</accession>
    <name>L0AAC3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin</text>
            <dbReference type="Rhea" id="RHEA:20772"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="EC" id="2.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1136"/>
    <dbReference type="EnsemblBacteria" id="AFZ70858">
        <property type="protein sequence ID" value="AFZ70858"/>
        <property type="gene ID" value="Calag_1136"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1136"/>
    <dbReference type="eggNOG" id="arCOG01322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1682776_0_0_2"/>
    <dbReference type="OMA" id="QLMTNTH"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09210">
        <property type="entry name" value="Riboflavin_synthase_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006399">
        <property type="entry name" value="Ribfl_synth_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01506">
        <property type="entry name" value="ribC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="156" mass="17129" checksum="1AB3E5EEF028587F" modified="2013-03-06" version="1">MKEKKCVGIIDTTFSRVDMGSIALKVLRDLLPDYMIIRHTVPGIKDLPGEARRLIDSGCDGIITLGWVGKKQVDKYSYIALSVGLVMLSVLTGKIIIDVTVHEDESDNEEELKKIAIERTKAHAENLAILLKEDGEGLVKKAGQGVRQGYENVGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAC8</accession>
    <name>L0AAC8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(FAD)-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232277.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0624"/>
    <dbReference type="EnsemblBacteria" id="AFZ70379">
        <property type="protein sequence ID" value="AFZ70379"/>
        <property type="gene ID" value="Calag_0624"/>
    </dbReference>
    <dbReference type="GeneID" id="14211884"/>
    <dbReference type="KEGG" id="clg:Calag_0624"/>
    <dbReference type="eggNOG" id="arCOG01069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_3_2"/>
    <dbReference type="OMA" id="DKNHTNY"/>
    <dbReference type="OrthoDB" id="40511at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="1">
        <location>
            <begin position="325"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="443" mass="49686" checksum="7B94A6F8F85D4B2D" modified="2013-03-06" version="1">MNKETLAIIGGGDAGMTTASWARRRKPHMNIIVFEKTNLISHAPCGLPYFIEGLFDDEKLLSAYTPEEFEKERNVNIRINHEIIELDLDNRVIYAKNRNNNDIIKLEYDYLAIATGSKPKKIKYDNESRIFYVHHPSLAREVKEKIMNLNNVAIIGGGILGVELAEALVRNGKNVLLIHKNAYLLNKMLDNDMASYINNYVSKDIKLKLNEEVLEITDGGRVIITNNGKYEVDGTIVSIGVEPNTELINDKNMIGETKAIKTDEYMRTSYKDVYAVGDVAESTNIITGMPDWQPFAPVAGKMGFTAGNHIGGVNYRFPGLIGTAITKYGEYFIAKTGLTENEAKKYGFKTISTIIRSNTRARYYPGGKEIIIKLIADENTQKLIGAQIIGQEEVLGRIDLLALAIMKSNTLYDLFYLEHAYMPAISRSWDPVILAARSLLTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAE3</accession>
    <name>L0AAE3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0284 protein Calag_1119</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0284 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1119"/>
    <dbReference type="EnsemblBacteria" id="AFZ70841">
        <property type="protein sequence ID" value="AFZ70841"/>
        <property type="gene ID" value="Calag_1119"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1119"/>
    <dbReference type="eggNOG" id="arCOG04272">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053134_0_0_2"/>
    <dbReference type="OMA" id="TRWVAED"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01086">
        <property type="entry name" value="UPF0284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002805">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38811">
        <property type="entry name" value="PTHR38811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00303">
        <property type="entry name" value="TIGR00303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="337" mass="36565" checksum="F36337A8B7AFEDC3" modified="2013-03-06" version="1">MKAVAIYVGGSTKTSTIEGISIAGSNSQDTLYTPTLDLEYVINGIPITKKEIPVTPNGLPTPAVITRSILKKLNIQYFVVDSGLYYKLKVPHIKIPSSIPGENIYSSNAFPYGTAKNIFEESKLLGEIISSKQDIVLIGESIPGGTTTAAAIMEALGYNALKFISSASPKNPRDLKEKVISNALKRIDPNDNVFSIIDKVGDPVHISMAGIAAGSLKNSSKILLAGGTQMGAVVSILSKLNYLDNRIKIATTSWIAKDKESNIFKLIEQIDKRIEIIVSDINFSDAKYEGLKLYEEGYVKEGVGAGGTMILSKYLGLSVYEIKNSIYEEYERLRSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAE4</accession>
    <name>L0AAE4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Indolepyruvate oxidoreductase subunit IorA</fullName>
            <shortName evidence="14">IOR</shortName>
            <ecNumber evidence="14">1.2.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Indolepyruvate ferredoxin oxidoreductase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">Calag_0228</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 14">Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:12645"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57271"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="EC" id="1.2.7.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14 15">Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Heterodimer of the IorA and IorB subunits.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.8" evidence="14"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231908.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0228"/>
    <dbReference type="EnsemblBacteria" id="AFZ70010">
        <property type="protein sequence ID" value="AFZ70010"/>
        <property type="gene ID" value="Calag_0228"/>
    </dbReference>
    <dbReference type="GeneID" id="14211488"/>
    <dbReference type="KEGG" id="clg:Calag_0228"/>
    <dbReference type="eggNOG" id="arCOG01609">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017727_0_0_2"/>
    <dbReference type="OMA" id="IGDSTFM"/>
    <dbReference type="OrthoDB" id="20764at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043805">
        <property type="term" value="F:indolepyruvate ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017721">
        <property type="entry name" value="IorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="PTHR43710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006439">
        <property type="entry name" value="Indolepyruvate_ferr_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03336">
        <property type="entry name" value="IOR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="16">
        <location>
            <begin position="563"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="16">
        <location>
            <begin position="593"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR006439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR006439-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFZ70010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="632" mass="69228" checksum="DA993ED73B125C23" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAF2</accession>
    <name>L0AAF2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA-like transporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0238"/>
    <dbReference type="EnsemblBacteria" id="AFZ70020">
        <property type="protein sequence ID" value="AFZ70020"/>
        <property type="gene ID" value="Calag_0238"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0238"/>
    <dbReference type="eggNOG" id="arCOG00271">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_978689_0_0_2"/>
    <dbReference type="OMA" id="MTLYQLA"/>
    <dbReference type="OrthoDB" id="76253at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="138"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="276" mass="31155" checksum="C4AAB27FC9DB2602" modified="2013-03-06" version="1">MKKEFAELFAIYIIASVFLYFFAKLGVTYTNPATLMMIRYIISGIILFSISRKLIIDKNVLILAIFTTTSTIFWGYGLLYVSPAVSSVLSYTMPLFSMILAIFIINEKPNHYEIIGLIIGFLGLGIYGSTLFKGFTKIGMILTLINAVFWALFSIYYRKLSKYDPISLNATQFIIGSGFMGLIDIFSIRKGFYFIPSLKLLESIVYISTIGGAFQFLIWNYLLKLERVNKVTIFAYIIPVATTIIQALLYKSLPKLFEIIGLLIMISGVIIARLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAH4</accession>
    <name>L0AAH4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mg-chelatase subunit ChlD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1199"/>
    <dbReference type="EnsemblBacteria" id="AFZ70918">
        <property type="protein sequence ID" value="AFZ70918"/>
        <property type="gene ID" value="Calag_1199"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1199"/>
    <dbReference type="eggNOG" id="arCOG02902">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1431579_0_0_2"/>
    <dbReference type="OMA" id="IAADVEW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="189" mass="21210" checksum="9CED9359DAED65EF" modified="2013-03-06" version="1">MLKFIGEAVIIGVDTSISMARKDYKPNRFENAKRAASIIARSLFSRNLPTLLSLMIFYRYSFPLTDLTDRLEVIEKAILQLKIMGKATAPSEIIKDAYLILRNVNPGYHKRIILITDAGFNEGVSLEMSALLLSISEIELDMLTFGSIPKSIFEHIDRSVKNTKGVWLHSSNTDEILANAAKLGEMYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAJ1</accession>
    <name>L0AAJ1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-phosphopantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphopantothenate synthetase</fullName>
            <shortName evidence="1">PPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27930"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal phosphopantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.36" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0335"/>
    <dbReference type="EnsemblBacteria" id="AFZ70112">
        <property type="protein sequence ID" value="AFZ70112"/>
        <property type="gene ID" value="Calag_0335"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0335"/>
    <dbReference type="eggNOG" id="arCOG04262">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078701_0_0_2"/>
    <dbReference type="OMA" id="PKSHPRY"/>
    <dbReference type="OrthoDB" id="76877at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02224">
        <property type="entry name" value="PPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002855">
        <property type="entry name" value="PPS/PS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038138">
        <property type="entry name" value="PPS/PS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40695">
        <property type="entry name" value="PTHR40695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02006">
        <property type="entry name" value="PPS_PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004853">
        <property type="entry name" value="UCP004853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="260" mass="29000" checksum="47E82EBE81B8F942" modified="2013-03-06" version="1">MNIEDIPKNHPRYQSLVTREKLVDFFNKGIVVAHGLVAQGRGEAFDYILGEKSHDFALDAEKVTVAYLLLSQSPIISVNGNYAALAGEEIVELSNSLNVPIEVNLFHRSEERIKKIENYLKDIGAKNIMGSECNKVKLPNLEGPRGIVCENGIYKSDFVLLAIEDGDRTQALRNLGKTVSAIDLNPFSRTAQAASITIVDEAIRATKNMIEFSKELSQLSRCELLKITSMYDNKSILSKAFNQMFVNLKNAYEKGIIFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAP7</accession>
    <name>L0AAP7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1279"/>
    <dbReference type="EnsemblBacteria" id="AFZ70993">
        <property type="protein sequence ID" value="AFZ70993"/>
        <property type="gene ID" value="Calag_1279"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1279"/>
    <dbReference type="eggNOG" id="arCOG02103">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1313073_0_0_2"/>
    <dbReference type="OMA" id="EDCEVIN"/>
    <dbReference type="OrthoDB" id="67368at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="209" mass="23936" checksum="43DC5DF730D7B23B" modified="2013-03-06" version="1">MYCQQEDCEVINLIINIITPKKGGVPGFNAYHVIETLKFLKNKDAGRPFLSKYLNLGEASVKTMLKRLKENNLIIQIGKHNKLTKNGEMVLKFFESKLNIFESKLNIEGLEDCLILVLEMNPPKDLTSIYKIRDQIISSSCKIAVVGFIDNKNLGFPGLPDYLQNELINCSKKYSYIVNRGVNIITPRYCMQSLYSFYINIMSQCCLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAR1</accession>
    <name>L0AAR1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232003.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0328"/>
    <dbReference type="EnsemblBacteria" id="AFZ70105">
        <property type="protein sequence ID" value="AFZ70105"/>
        <property type="gene ID" value="Calag_0328"/>
    </dbReference>
    <dbReference type="GeneID" id="14211588"/>
    <dbReference type="KEGG" id="clg:Calag_0328"/>
    <dbReference type="eggNOG" id="arCOG00447">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_1_2"/>
    <dbReference type="OMA" id="HIAGMRN"/>
    <dbReference type="OrthoDB" id="83858at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="16"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="ETF_alpha" evidence="2">
        <location>
            <begin position="177"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="301" mass="33292" checksum="85B971B60B07BB4C" modified="2013-03-06" version="1">MVDVLVVVQKEIDASELLTIAKKVGEPIALTYGNSEAEKLTKYFNKVYKIKEDDPNSIFFAIKYLYEKFNPKLVIGMTSKNLKDAYSRLAGIYDLPFATDIFDFNVSGSKVTYKRSFLSGRAIETEEASVPLLLLVSPRKTQRSEGNYNGNIEELSVGNSSNVVIKERKEKVKGGVNLEAAEFIISVGRGFKSKEDLKLAFDLAELVGAQIGCSRPIAADLKWLTEDHWVGLSGKKVAPKVYLMFGISGAPQHLAGITDAKTVIAVNNDKTAPIFKNADYGIVADLYQFIPILTKKLKEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAU9</accession>
    <name>L0AAU9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0486"/>
    <dbReference type="EnsemblBacteria" id="AFZ70252">
        <property type="protein sequence ID" value="AFZ70252"/>
        <property type="gene ID" value="Calag_0486"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0486"/>
    <dbReference type="eggNOG" id="arCOG01648">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_28_1_2"/>
    <dbReference type="OMA" id="GWSFNAD"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="202" mass="22596" checksum="281BF9E8C467EFCF" modified="2013-03-06" version="1">MRNMYTEKIVKVNGLNIHYYDDGNGYPVLLVPGIRYNAKTWIDVGTYDIIYNEKFRVISIDPPGQGKSDKGIYDEDTEYIFVKDFMDALGIKDAVIVGASSGGYAAAGVAANFPERVKGAVIVGGVRIINYKEKLKNMEGKPILLIWGTKDDIAPISNAHLILNSVKSSELIYLGTQHACYLEKPKEFNELIRNYLKNKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAV3</accession>
    <name>L0AAV3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232446.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0808"/>
    <dbReference type="EnsemblBacteria" id="AFZ70549">
        <property type="protein sequence ID" value="AFZ70549"/>
        <property type="gene ID" value="Calag_0808"/>
    </dbReference>
    <dbReference type="GeneID" id="14212068"/>
    <dbReference type="KEGG" id="clg:Calag_0808"/>
    <dbReference type="eggNOG" id="arCOG03176">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051062_3_0_2"/>
    <dbReference type="OMA" id="WKKGNTF"/>
    <dbReference type="OrthoDB" id="110547at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="181" mass="19068" checksum="33409D75D99DDF0F" modified="2013-03-06" version="1" precursor="true">MSKEEVWGNPAALGLVGFGLTTIALSLANAGIIPTTGLTIGYAVSWGGLAQVFAGWISFRRNDTFGGTAFSGYGLFWIGLALALILGLHVSSSELGLWMLLWGIFTLYMDVGAILAKARVLSIVLTLLFITFFILSAADFSTSSMILKAAGWIGLITGISAVYLSMAIVINTVKGKVVVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAX5</accession>
    <name>L0AAX5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KH-domain/beta-lactamase-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232960.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1354"/>
    <dbReference type="EnsemblBacteria" id="AFZ71063">
        <property type="protein sequence ID" value="AFZ71063"/>
        <property type="gene ID" value="Calag_1354"/>
    </dbReference>
    <dbReference type="GeneID" id="14212614"/>
    <dbReference type="KEGG" id="clg:Calag_1354"/>
    <dbReference type="eggNOG" id="arCOG00543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_5_1_2"/>
    <dbReference type="OMA" id="YLDGMIW"/>
    <dbReference type="OrthoDB" id="5321at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019975">
        <property type="entry name" value="aCPSF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033769">
        <property type="entry name" value="KH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17214">
        <property type="entry name" value="KH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03675">
        <property type="entry name" value="arCOG00543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="194"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="427"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="667" mass="75367" checksum="58C8CD1970BF3D15" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAZ4</accession>
    <name>L0AAZ4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0542"/>
    <dbReference type="EnsemblBacteria" id="AFZ70302">
        <property type="protein sequence ID" value="AFZ70302"/>
        <property type="gene ID" value="Calag_0542"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0542"/>
    <dbReference type="eggNOG" id="arCOG06105">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2103372_0_0_2"/>
    <dbReference type="OMA" id="LFRGCPR"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="115" mass="12400" checksum="CF5F5A3F04313E49" modified="2013-03-06" version="1">MKILSSKEENQPQLEKNVNDKKTNVNDKKTSKYIGIALIAIGVILLVFVFYEAYLSFLNPGFLNLLGPLNSSSSNSVPISFTAEALVILLVKVAFLGISLAAASTILSKGVELIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB00</accession>
    <name>L0AB00_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232108.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70210">
        <property type="protein sequence ID" value="AFZ70210"/>
        <property type="gene ID" value="Calag_0442"/>
    </dbReference>
    <dbReference type="GeneID" id="14211702"/>
    <dbReference type="KEGG" id="clg:Calag_0442"/>
    <dbReference type="eggNOG" id="arCOG08618">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1514528_0_0_2"/>
    <dbReference type="OMA" id="YENPHMI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="192" mass="20779" checksum="20A33A4F5086BF6E" modified="2013-03-06" version="1">MKSKEPIKVEIDSSKLSVDGRSYDTTHVLIQGAQEISGEITSTQVKITALFADLPQVEPTMEEATKVVANGSEFIVDVLGEKIQNALETEEGYILSGDIITIKFESDENGEDIIIKIPKVGNIKTNKLSLQLDGELSSNIMMQPFIIGAISIKGPTKVKILVSGESINILKDDSKISNEGKKIVSESTAQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB01</accession>
    <name>L0AB01_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232953.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1347"/>
    <dbReference type="EnsemblBacteria" id="AFZ71056">
        <property type="protein sequence ID" value="AFZ71056"/>
        <property type="gene ID" value="Calag_1347"/>
    </dbReference>
    <dbReference type="GeneID" id="14212607"/>
    <dbReference type="KEGG" id="clg:Calag_1347"/>
    <dbReference type="eggNOG" id="arCOG03047">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1269860_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="217" mass="25011" checksum="178C83D41B229587" modified="2013-03-06" version="1">MSMDSEYLNLARRKFDEGIKLMNDGLLIQAANNFIESSNYLFKIKNLDEESRLLLIKSLVNQGAIMINLGRYSLAINSLIKSWMLLKNDGNKDLLKATYINLISAFIASNRYDEAMNFINKLEGIDEESKAYALMYKSKILIDKRLTNNVGEYLEEARTIFDKLNMKDQLAAVIAIQVEYYNLIGDYEKAKEYTGELNTIAGKSLNYFIREYKKKCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB22</accession>
    <name>L0AB22_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="2">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Spermidine synthase</fullName>
            <shortName evidence="2">SPDS</shortName>
            <shortName evidence="2">SPDSY</shortName>
            <ecNumber evidence="2">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">speE</name>
        <name evidence="5" type="ordered locus">Calag_0864</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232501.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0864"/>
    <dbReference type="EnsemblBacteria" id="AFZ70604">
        <property type="protein sequence ID" value="AFZ70604"/>
        <property type="gene ID" value="Calag_0864"/>
    </dbReference>
    <dbReference type="GeneID" id="14212124"/>
    <dbReference type="KEGG" id="clg:Calag_0864"/>
    <dbReference type="eggNOG" id="arCOG00050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048199_0_1_2"/>
    <dbReference type="OMA" id="LWPGQSF"/>
    <dbReference type="OrthoDB" id="77175at2157"/>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="4">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="2">
        <location>
            <begin position="143"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="305" mass="35079" checksum="741AC12BAA32AC21" modified="2013-03-06" version="1">MSTNYPWHWIIEWSTPGTAHMHAVNKVYAFGQSKFQKWIIVDYVDLGKALVIDGKIQSSLYDEFVYHESLVHPAMILNGNPKKVLILGGGEGATAREALRFKSVEKVIMVDIDDQVVEVCKKYLPEWHQYSFYNSKVKVIIDDAEHYIDNTDEKFDVIISDLVDPEEAGPAVRLYTREFYNKIVNKLEKNGIFVTQSTSPVLTPTVHAVIFNTIKSVFKYATSYYSYIRSFEGIWGFVIASNDINVENVKNLDVDNMINKMAEGKNRYYDNESHAHMFNVPKFIRNILEKEKRVSTLSNPIYLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB51</accession>
    <name>L0AB51_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233015.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1411"/>
    <dbReference type="EnsemblBacteria" id="AFZ71118">
        <property type="protein sequence ID" value="AFZ71118"/>
        <property type="gene ID" value="Calag_1411"/>
    </dbReference>
    <dbReference type="GeneID" id="14212671"/>
    <dbReference type="KEGG" id="clg:Calag_1411"/>
    <dbReference type="eggNOG" id="arCOG07192">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2406192_0_0_2"/>
    <dbReference type="OMA" id="LIKMEIM"/>
    <dbReference type="OrthoDB" id="13352at183924"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="92" mass="10584" checksum="9579056F6B3B46DD" modified="2013-03-06" version="1">MSVWVETPYLNLVYDEIKKLTKDGEVPISEKEIISSLSRQGYDISPSDLVKLLIKMEIMGLIVVSSSTKEERLIKLNKTERHEEFVQVDNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB57</accession>
    <name>L0AB57_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232546.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0915"/>
    <dbReference type="EnsemblBacteria" id="AFZ70649">
        <property type="protein sequence ID" value="AFZ70649"/>
        <property type="gene ID" value="Calag_0915"/>
    </dbReference>
    <dbReference type="GeneID" id="14212175"/>
    <dbReference type="KEGG" id="clg:Calag_0915"/>
    <dbReference type="eggNOG" id="arCOG07240">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1036648_0_0_2"/>
    <dbReference type="OMA" id="LPFRGVN"/>
    <dbReference type="OrthoDB" id="74894at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="268" mass="31344" checksum="65BF17EC63281008" modified="2013-03-06" version="1">MKNLKISVIIPTLCNEFLLGALSSLENQKRKPDEVIVIYKCNNIIEKLIDNIDLSMEFVKQEKGHVTNALNIGKNKASGDIIVITDDDVILPKDWIKNYEIYFNSLKENYAGVCSRDIWINENKEIIKSPDDKLITSLYRNFYVKYFIKPHILFKDFKNGVFISKNYKIFHGSCIPKGKCISLPFRGVNMAFFREKINDIDFPEINNVKYYHMYEQYIGVKLVKKGLSYLYVPDNPVFHYYHKSLSKNNKAKEEDKIMLNLIKNEIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB78</accession>
    <name>L0AB78_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type branched-chain amino acid transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0645"/>
    <dbReference type="EnsemblBacteria" id="AFZ70397">
        <property type="protein sequence ID" value="AFZ70397"/>
        <property type="gene ID" value="Calag_0645"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0645"/>
    <dbReference type="eggNOG" id="arCOG01020">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_4_1_2"/>
    <dbReference type="OMA" id="ISHAGYN"/>
    <dbReference type="OrthoDB" id="35461at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="55"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="437" mass="47155" checksum="FA3A7492451DC9D9" modified="2013-03-06" version="1">MYIILNKTLNRSVSGTTIAIIIVVIVIIIVGAVVGGYYATRKPTTTSTVSAPPYILIGTLYASTGSFATSSMSQYEGLQTWAKWVNESGGIYVKEYGKKIPVKIVAYDDLSSTSTAQSDYQQLLNVNHVNILVADFGSVLTAPAVSLTNASHILLWDVTGSSYAFFVNNPYIIDTSIPVSGAWVSVIAEFLHSLNISKVAVLYASNDFNAYQDYLLGTYFKQYGITPILNESYPTSTSDFSSYIATLESLKPQAVIEFGYPTDDIPFLNQLASSKASFPLIYTNYPGLQLPNLVSGVGGNMNGTFTGAFPPIVEYKVNYGPNLTQFASLFESTYPGVPINYNVLAGFNAGLIIQAAIQDAGTFTNQTALKQAVLNDISGKIVTLTGPFEITQNGEQLGETPAIAQIWIYPNMTTKLTIVWPSNLANGTAVYPEPPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB88</accession>
    <name>L0AB88_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232305.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0656"/>
    <dbReference type="EnsemblBacteria" id="AFZ70407">
        <property type="protein sequence ID" value="AFZ70407"/>
        <property type="gene ID" value="Calag_0656"/>
    </dbReference>
    <dbReference type="GeneID" id="14211916"/>
    <dbReference type="KEGG" id="clg:Calag_0656"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_1_2"/>
    <dbReference type="OMA" id="TAFILME"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="161" mass="18487" checksum="F01086AFDDFE5C25" modified="2013-03-06" version="1">MKQKTIDDKDILIIKNLEKDSRKPWRQLANELNLSEATIYLRIKKLEENEIIKGFTVKVDPLKIGLAMTVFLLIKVRAENLIQVKKELVRLDYIVELHEITGSYQFLAKLYAPSQREASKAIEEIMKIEGIVEVNTLISLSSLKSEENVIDALGYWLNSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB95</accession>
    <name>L0AB95_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ARMT1-like_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232586.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0966"/>
    <dbReference type="EnsemblBacteria" id="AFZ70689">
        <property type="protein sequence ID" value="AFZ70689"/>
        <property type="gene ID" value="Calag_0966"/>
    </dbReference>
    <dbReference type="GeneID" id="14212226"/>
    <dbReference type="KEGG" id="clg:Calag_0966"/>
    <dbReference type="eggNOG" id="arCOG04410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071520_1_0_2"/>
    <dbReference type="OMA" id="LFRAKCD"/>
    <dbReference type="OrthoDB" id="89855at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014444">
        <property type="entry name" value="PH1575-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006593">
        <property type="entry name" value="UCP006593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="SSF111321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARMT1-like_dom" evidence="1">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="272" mass="31456" checksum="F474BE765861A979" modified="2013-03-06" version="1">MNMIDEKCKLCLIENRVKDLIRLKGGDKIPYLLKDLSYQLESNKDRDSLFVDSFNYIKKLIKDEDPYKELKMNLNKIGKEASLIVRKELIENNWNLDLALKFSASANIIDINVLGYEYVDLKDALHDEVKVYEKINLPKEKEIYLIFDNSGEVYIDLLLKESLIKNGYNVKTVIRKNSYEIDVTSDEIDADIIIDGNYSPIKKINEGFIIAKGIANLEAYLFSNKKIDTLHLFRAKCEVLAERFNVKKNTPIIISGKNLLNVLKINNLTFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABA7</accession>
    <name>L0ABA7_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0673"/>
    <dbReference type="EnsemblBacteria" id="AFZ70422">
        <property type="protein sequence ID" value="AFZ70422"/>
        <property type="gene ID" value="Calag_0673"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0673"/>
    <dbReference type="eggNOG" id="arCOG00585">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_2"/>
    <dbReference type="OMA" id="NMAYFTP"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="312" mass="34804" checksum="6275585F4BA6F0AE" modified="2013-03-06" version="1">MSELSFRIKNEEFKEKSSKNAAYDYKEQAQRMRALQDEQRKVVEKMKKIPYKIAILSSKGGVGKSFVTSNLAIALSSLGKNVAVLDADFHGPSIPKMLGIELSKGLLARDDGSIIPAVSRHGVKVVSVGLMLPTEDTPVIWRGSIKTTAIRQLLAYTDWEGIEYLLIDLPPGTGDEQLTIAQIIPNLTGFLMVTIPSEISKYVVKKAANFAQKINVPILGIIENMSYFKCDDGKIYYIFGKGAAEEISKEYNITFLGKIPIDPKIRESNDNGIAFFIDYPELEASKIFMDISKKFLEVLEKANKKEENNLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABG9</accession>
    <name>L0ABG9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA(Met) cytidine acetyltransferase TmcA</fullName>
            <ecNumber evidence="9">2.3.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tmcA</name>
        <name evidence="11" type="ordered locus">Calag_1545</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43788"/>
            <dbReference type="Rhea" id="RHEA-COMP:10693"/>
            <dbReference type="Rhea" id="RHEA-COMP:10694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TmcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.193" evidence="9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233140.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1545"/>
    <dbReference type="EnsemblBacteria" id="AFZ71243">
        <property type="protein sequence ID" value="AFZ71243"/>
        <property type="gene ID" value="Calag_1545"/>
    </dbReference>
    <dbReference type="GeneID" id="14212807"/>
    <dbReference type="KEGG" id="clg:Calag_1545"/>
    <dbReference type="eggNOG" id="arCOG01951">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004652_1_0_2"/>
    <dbReference type="OMA" id="NEPDDLG"/>
    <dbReference type="OrthoDB" id="2707at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01886">
        <property type="entry name" value="tRNA_acetyltr_TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="Helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024914">
        <property type="entry name" value="tRNA_acetyltr_TmcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="PTHR10925"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="DUF1726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="Helicase_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="10">
        <location>
            <begin position="530"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="9">
        <location>
            <begin position="597"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="637"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ71243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="828" mass="95237" checksum="9271F935B3DA4A1D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABK1</accession>
    <name>L0ABK1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protease subunit, stomatin/prohibitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232404.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0763"/>
    <dbReference type="EnsemblBacteria" id="AFZ70507">
        <property type="protein sequence ID" value="AFZ70507"/>
        <property type="gene ID" value="Calag_0763"/>
    </dbReference>
    <dbReference type="GeneID" id="14212023"/>
    <dbReference type="KEGG" id="clg:Calag_0763"/>
    <dbReference type="eggNOG" id="arCOG01915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_3_3_2"/>
    <dbReference type="OMA" id="MFQVTDP"/>
    <dbReference type="OrthoDB" id="49614at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="50"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="313" mass="35206" checksum="2F4AB8523F60F71E" modified="2013-03-06" version="1">MGNLFYILLIKYTFLNFQNLIIIEAKNLVNLALLAIEIFIALIVIIILLSGIKVVKEWERIPVLVLGRFRGLKGPGIVYVIPLISQIPFRISTRLQALAFRTEQSLTKDNVPVIVDAVMYYQPVDLQKVVLSVENYNVATQLAAETTLREVIGQTVLDELLAERDKVAALARNIIDSKTEAWGVKVTAVEIRNVEIPHDLVEAMSRQAQAERERRARVTLAEAEYEAAQKMVEAANLYKDHDEAFMLRWMNMIYELGMEGKNTLMLIPVNLPAAGPTSGSPLGVFGIQKMQELMQTQQTQQSQQTKQQGEQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABP4</accession>
    <name>L0ABP4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232363.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0720"/>
    <dbReference type="EnsemblBacteria" id="AFZ70465">
        <property type="protein sequence ID" value="AFZ70465"/>
        <property type="gene ID" value="Calag_0720"/>
    </dbReference>
    <dbReference type="GeneID" id="14211980"/>
    <dbReference type="KEGG" id="clg:Calag_0720"/>
    <dbReference type="eggNOG" id="arCOG07466">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108881_1_0_2"/>
    <dbReference type="OMA" id="VYWRGGL"/>
    <dbReference type="OrthoDB" id="88522at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="197" mass="22483" checksum="43B17E1691CD5777" modified="2013-03-06" version="1">MRKITIFDVFMIILPWILWYFTFDVFYSHFIYAMALSVSVLGIISLTRKEVREKYKSCNALCILLALLIAIILYFVFYGGNIVSAKLGLEGEVLYVYGLVPKGLLSIFLLALIGVMEEAYWRGLLQQVILEKKLNVSWLFAPLFYGFVHSVSLNLILVVAALIVGLFLSFTAEKFGLIASSIVHVVWIYFMFLKILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABQ2</accession>
    <name>L0ABQ2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar pyrophosphorylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0816"/>
    <dbReference type="EnsemblBacteria" id="AFZ70557">
        <property type="protein sequence ID" value="AFZ70557"/>
        <property type="gene ID" value="Calag_0816"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0816"/>
    <dbReference type="eggNOG" id="arCOG00663">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_2_0_2"/>
    <dbReference type="OMA" id="WYGDILA"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="242" mass="27973" checksum="99B36A04ABD3DFAA" modified="2013-03-06" version="1">MDLTAVIPAGGEGSRFKPYTDIVPKPMIPLGEEEKPILDYIVHHLSRNGFEHIILLVNYKWKYIKNYFQDGNRYNLKIDYSIDDDKYSNTGGSLLKAYKNNLINSDPVLIWYGDILANLNPNDIVKVHKEEDLDALLVVADKYQIPVGVAEIDENNNIVRLREKPWYEIKVTIGILTLNVDVLKSIENALGTKFDIMGDLIPYMIKNKKKVKAYIYNEEWIDVGSLERYKKIDEKILKKVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABQ7</accession>
    <name>L0ABQ7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232377.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0736"/>
    <dbReference type="EnsemblBacteria" id="AFZ70480">
        <property type="protein sequence ID" value="AFZ70480"/>
        <property type="gene ID" value="Calag_0736"/>
    </dbReference>
    <dbReference type="GeneID" id="14211996"/>
    <dbReference type="KEGG" id="clg:Calag_0736"/>
    <dbReference type="eggNOG" id="arCOG01937">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_431251_0_0_2"/>
    <dbReference type="OMA" id="VIDARIW"/>
    <dbReference type="OrthoDB" id="133436at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="639" mass="69755" checksum="B9BF72345CEEFEBC" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABR6</accession>
    <name>L0ABR6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232766.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1147"/>
    <dbReference type="EnsemblBacteria" id="AFZ70869">
        <property type="protein sequence ID" value="AFZ70869"/>
        <property type="gene ID" value="Calag_1147"/>
    </dbReference>
    <dbReference type="GeneID" id="14212407"/>
    <dbReference type="KEGG" id="clg:Calag_1147"/>
    <dbReference type="eggNOG" id="arCOG01978">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_622034_0_0_2"/>
    <dbReference type="OMA" id="YENIDWI"/>
    <dbReference type="OrthoDB" id="58231at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="440" mass="50924" checksum="34E0C99960E1CC1E" modified="2013-03-06" version="1">MKNKKKVLLLTTNKKFIKIPSKKLVSFDILEIKDLYNMNLDQIVNILSNIMDKYDNIILPGNIIWDFSDFNGKIIKGTEFYNYLFDLLNYVEIEKLSPKVSADKLFPEQIKKIVEKKKKAYKKPIFKIRDLKIYKRYPIRLFTEIFLHKEERMNDLMKVIKSYIQDGADTIILGVFPSIQYEYLKDVIHNIRELSSIPIGLDANIDILKNFKNDVDILMSFTINNIYENIDWIFDRVSVLLINDINHDMIKKIRDLKRKGIKLILDPIAYPAIYPGFFNTLIRAKKLSNLGLPIMIGINNVTELMDADTTGTNAFATFLSIESGASIILTGEVSVKNRGSVFEVKNAINMAEESIILKKPPKDLSLNLLGLKEKKFLENDIKIYGNRDNIYIEISGKTKEISCKDNCPLSKLYDLDKEDLAKLSILIYRYCSPWSIIWNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABU2</accession>
    <name>L0ABU2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232417.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0778"/>
    <dbReference type="EnsemblBacteria" id="AFZ70520">
        <property type="protein sequence ID" value="AFZ70520"/>
        <property type="gene ID" value="Calag_0778"/>
    </dbReference>
    <dbReference type="GeneID" id="14212038"/>
    <dbReference type="KEGG" id="clg:Calag_0778"/>
    <dbReference type="eggNOG" id="arCOG01713">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1607061_0_0_2"/>
    <dbReference type="OMA" id="VLWERFP"/>
    <dbReference type="OrthoDB" id="106375at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018747">
        <property type="entry name" value="DUF2299"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10061">
        <property type="entry name" value="DUF2299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="165" mass="18785" checksum="D4C9F8E8A0B7B759" modified="2013-03-06" version="1">MGLKEEIIKWLKEENLEVSEIPIPKDAPIEWAINTMVNAPFRVAISIQRPKGKTEKFAFTMAVKVAEQHKEKIIKMPEQERANMIGELLKNLYMMCPSCITIFQPDINNPDNIIVTKIIYQDKITPSEVTDSVRILSNAYGLIVTHFTIKLGGSFKQGEQTVMHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABV9</accession>
    <name>L0ABV9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase maturation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0857</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0857"/>
    <dbReference type="EnsemblBacteria" id="AFZ70597">
        <property type="protein sequence ID" value="AFZ70597"/>
        <property type="gene ID" value="Calag_0857"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0857"/>
    <dbReference type="eggNOG" id="arCOG00636">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041631_0_0_2"/>
    <dbReference type="OMA" id="PRVVMGH"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="66"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="175"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="374" mass="41658" checksum="4FD3D75F2421255C" modified="2013-03-06" version="1">MLVTTDKGNNYRVFALISNKIIGKVNRKLFEDTIYPNLGVKSSDVKVGPQFGVDFGVLRVGDKDLIIEVDPVYIVPEYGWKKSSWFAVHILASDVAVSGIPPKYLFIDLNLPMKMTDDEFKEMWLNIHNECLKLGISIVAGHTGRYEGIDYPMIGGATLIGITDKDNYVSPAMAEPGDLILMTKGPAIETAGILASLFPQVLEKDYGKEFALNAQNIFWLQSVVDDALTLSKLGLRKGVKAMHDATEYGVWGALNDIAEASNIRIDVYKDKLFIREDVSKVLDSFSRFTNLKIDPYASISEGTLIAAISKDMKDEAINLLKERGIEAQIIGEAKEGRGVYLIDGNEKEIKQPEKDDFWPIFYKTLELVKGGKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC17</accession>
    <name>L0AC17_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase maturation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232871.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1258"/>
    <dbReference type="EnsemblBacteria" id="AFZ70974">
        <property type="protein sequence ID" value="AFZ70974"/>
        <property type="gene ID" value="Calag_1258"/>
    </dbReference>
    <dbReference type="GeneID" id="14212518"/>
    <dbReference type="KEGG" id="clg:Calag_1258"/>
    <dbReference type="eggNOG" id="arCOG00636">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041631_0_0_2"/>
    <dbReference type="OMA" id="NDIAVRG"/>
    <dbReference type="OrthoDB" id="34102at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="38"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="154"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="341" mass="37327" checksum="385CDE2CDB2B592A" modified="2013-03-06" version="1">MSKWIGKLPSEILKEIVLDNANSFKKASTIIGSEIGEDAALIDLGSCILAIHSDPITEARYYAGSLAVDIVTNDLAVTGVRPRWLILDILMPEKSLYSSLNSIMESAVKEAKNLNVEIVGGHTESTPGLVSPIIIGTAIGCSCRDCYVPTRNAKEGDLIFQIKPAGLEGSSIIATDFREKAIKAGVPLNIIESAADFVKRISIMKEALELSDRKLVNSMHDPTEGGLLGGIYEIAYSSNHDIEIYEEKVFVEEETKIISEKMNIDYLKLISSGSILASIPINKRDEAENVLKNLNVKYSIIGRVLNPSDNPKVFVKKGDKINIINSPPQDEISRLWAEKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC38</accession>
    <name>L0AC38_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP-binding protein HflX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232896.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1285"/>
    <dbReference type="EnsemblBacteria" id="AFZ70999">
        <property type="protein sequence ID" value="AFZ70999"/>
        <property type="gene ID" value="Calag_1285"/>
    </dbReference>
    <dbReference type="GeneID" id="14212545"/>
    <dbReference type="KEGG" id="clg:Calag_1285"/>
    <dbReference type="eggNOG" id="arCOG00353">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_2_0_2"/>
    <dbReference type="OMA" id="FNNHAHV"/>
    <dbReference type="OrthoDB" id="33372at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="7">
        <location>
            <begin position="186"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="238"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="306"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="336"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="360" mass="41214" checksum="CC449486CD34EDD3" modified="2013-03-06" version="1">MELNKTKNAFLILSSKFYNHFEEALILANTAGYEIVGTKRFRGGKRITDGLIEIVKNNKKELDFDTVIYYGDIEPSSVFKLEKETKIRVLDRVQLILEIFALHAGSKEALLQIEMARIRHDLPIIREYIRRTKLGELPGFLGPGRYGIDTYKKQLTSRLSKIKRDLEDLRITEQERLKRRKELGMINIPIVGYASAGKTSLFNIITGESKPVGPEYFTTLFPKHKTINYNGLKLAFVDTVGFIRDVPPEVIEAFYSTLEEVTISDIIVFVIDITENENDIKEKILAGTDILKKLNALNKPIIFALNKIDEIDKIKIYDKIEFVKKTFPNDKMVLISAKKNIGIDALLNEIINITKNLNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC43</accession>
    <name>L0AC43_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_1290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1290"/>
    <dbReference type="EnsemblBacteria" id="AFZ71004">
        <property type="protein sequence ID" value="AFZ71004"/>
        <property type="gene ID" value="Calag_1290"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1290"/>
    <dbReference type="eggNOG" id="arCOG00480">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043611_0_1_2"/>
    <dbReference type="OMA" id="QWIEGAR"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ71004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="303" mass="34203" checksum="3B71F1718FC53941" modified="2013-03-06" version="1">MVNMSKVRIKQIVMGSRPWALPMFIATYSIGVFTGFYYYKLFGLYLVLLIIIGAVGELLIHMMTNIINDYYDYIKGIDKANNTKRYHLILNSNLDPKDVKNISLILGIIGLLIGIFIAIMGRPWALLLGFIGFLLGLEYSAPPLYLKYYALGDFSVIISMLLLTLAGFYMYTGKISIVGILIGLPISLLIDDVLMANNIRDINRDKTSGAKTLSIILGYNKSKYLYISFIILSYTILAFLIIFKIYPIYVLIEVLTLPQAINIIKDALNNNFDFLDVKNAKLVSNFGILFVISLIIYIIIKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC63</accession>
    <name>L0AC63_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1312"/>
    <dbReference type="EnsemblBacteria" id="AFZ71024">
        <property type="protein sequence ID" value="AFZ71024"/>
        <property type="gene ID" value="Calag_1312"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1312"/>
    <dbReference type="eggNOG" id="arCOG07757">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2115361_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="114" mass="13556" checksum="C8C57BFB6C7DCAE1" modified="2013-03-06" version="1">MIIMGASSEGADAIKEIKRILEILLENYNKFFNNDERLNSDGIRLYKRISYYLYLIDQKDIVNSYKKSFRNPTLENILDFARHFIKDVDNIIKISAFNEIYYDTVFKDVKLNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC76</accession>
    <name>L0AC76_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TRASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0895"/>
    <dbReference type="EnsemblBacteria" id="AFZ70635">
        <property type="protein sequence ID" value="AFZ70635"/>
        <property type="gene ID" value="Calag_0895"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0895"/>
    <dbReference type="eggNOG" id="arCOG04507">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185152_1_0_2"/>
    <dbReference type="OMA" id="GKIYYFC"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="1">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="73" mass="8590" checksum="5AEFBD1245C34EDB" modified="2013-03-06" version="1">MKKYIEKPLNKFSNYILVIQLIDPVCGMEVDKSSKYKTLYKGQVYYFCSENCLNSFKKDPEKYLKEGPKGMPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC86</accession>
    <name>L0AC86_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232542.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0909"/>
    <dbReference type="EnsemblBacteria" id="AFZ70645">
        <property type="protein sequence ID" value="AFZ70645"/>
        <property type="gene ID" value="Calag_0909"/>
    </dbReference>
    <dbReference type="GeneID" id="14212169"/>
    <dbReference type="KEGG" id="clg:Calag_0909"/>
    <dbReference type="eggNOG" id="arCOG01417">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053640_0_0_2"/>
    <dbReference type="OMA" id="FNERRFW"/>
    <dbReference type="OrthoDB" id="83551at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="444" mass="52239" checksum="84AA621B745E6F39" modified="2013-03-06" version="1">MEIFTIGPADINGKIGGGGIHNAEIIIRLPHLGFRVIYSPYPSILFWALNDEVYADSLHKTLRIMEQNKVIIPSIVFSYLEEKNKILKRHNIESNFFSKVDKFIKEKLKYIHYKDFPQLRDEEIKIMKDIISDVGNVQYIMNPTESTSEFIYFAKIFKKPIYNIIHHNPFNWYMALRKTASMFYMNSISNIIKLVRLSLFSPYSSIKYYYDKLISLNLPINFIWINPASYFQFRNSMNLNKNIKNYFIYPANAIDPLALSNESYDKENYFVYGGYLDLLKGLYDMPYILKELKNKIDDYIVFVGHSSNETTKYINKLKKIYPKIKFLGFLKNKEELFKIYSKAKGLIYPTHIDGYSLVILESLGVKTPVITYGIPELVYLYKNIKPVRIVNEFDFKSFANEIIKLSKTDNTRDLFDNTESFIRIHSSWDNVAKQYAKIFKETMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACA8</accession>
    <name>L0ACA8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1045"/>
    <dbReference type="EnsemblBacteria" id="AFZ70767">
        <property type="protein sequence ID" value="AFZ70767"/>
        <property type="gene ID" value="Calag_1045"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1045"/>
    <dbReference type="eggNOG" id="arCOG02640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1212573_0_0_2"/>
    <dbReference type="OMA" id="CAYNAST"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="228" mass="26152" checksum="3D84EE032D2F367D" modified="2013-03-06" version="1">MQIMAIDSLSKITLIEVLQNMAQDIQNVTAILLTNIRENSNVEYIEKFYRQELMSTKDKISRNKDRIFDYLASGRLELISYKEFYINTALQLECSISKLEAGIYRLLLSYSIEKGVDSDIYKAIEGLIGEIYNSSQSLVDLLRSISTGTKGNSEKRKMIEERFNKISDSEEKGDMIYREGLAKVLMKYSDKPSRLISFKETIEYLEDCLDCLFNSAVYIKLIGFSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACB5</accession>
    <name>L0ACB5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232966.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1360"/>
    <dbReference type="EnsemblBacteria" id="AFZ71069">
        <property type="protein sequence ID" value="AFZ71069"/>
        <property type="gene ID" value="Calag_1360"/>
    </dbReference>
    <dbReference type="GeneID" id="14212620"/>
    <dbReference type="KEGG" id="clg:Calag_1360"/>
    <dbReference type="eggNOG" id="arCOG01018">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056931_3_0_2"/>
    <dbReference type="OMA" id="PIMNLSH"/>
    <dbReference type="OrthoDB" id="93855at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="PTHR42786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="242" mass="27101" checksum="711C7715EC3B5255" modified="2013-03-06" version="1">MKKLRLIMVGIEGSVNLGYLLRLSENFDVDETYLVHPLASAYESFRWAVKASNKIYDVNIVDSLDKALEGVDLSICTSDESSARDVLRIPITPRQASELAEKVNGRVALVLGRESVGLTRDELKKCNLLCTIPSSKKYTALNVSNAGAIMLYELYLAKNKESKFELADKKTVDLIEAYAKALVYDSFEQNELEDIILAVKKVVSKSEKGEASRILKFISKICLKYGCKDKLNDYISKDVRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACC0</accession>
    <name>L0ACC0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70782">
        <property type="protein sequence ID" value="AFZ70782"/>
        <property type="gene ID" value="Calag_1060"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1060"/>
    <dbReference type="eggNOG" id="arCOG02836">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194986_0_0_2"/>
    <dbReference type="OMA" id="MIAYYLV"/>
    <dbReference type="OrthoDB" id="131108at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="78" mass="9381" checksum="1A22CB4977FB09B6" modified="2013-03-06" version="1">MIAYYLVKNMSQEKEVVYVSKDLYEKIKKYIKEQGTFNSVDELVEFMLNELLDQSTNEVMTKEDEEKVKDRLKRLGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACD7</accession>
    <name>L0ACD7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase/fumarate reductase, cytochrome b subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232602.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0982"/>
    <dbReference type="EnsemblBacteria" id="AFZ70705">
        <property type="protein sequence ID" value="AFZ70705"/>
        <property type="gene ID" value="Calag_0982"/>
    </dbReference>
    <dbReference type="GeneID" id="14212242"/>
    <dbReference type="KEGG" id="clg:Calag_0982"/>
    <dbReference type="eggNOG" id="arCOG02244">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1574898_0_0_2"/>
    <dbReference type="OMA" id="HRVTGFI"/>
    <dbReference type="OrthoDB" id="123358at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="169" mass="19530" checksum="56530BC1DFD6D207" modified="2013-03-06" version="1">MSEKEEYFGKKNIEMENRQGFWRASLNPWLIRAKNNPERVAFVLHRVTGFIIIAFLLAHILETDSPVWTQYYPIHGYSGWAAWTYIMGIESAWWAKLGEWIVAGAVFFHALNGFRLLLTEFFGVGIGKPVEPKPPYEAPTLNAPQRTWLYIEFIVAIVLWAFSAFLIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACG4</accession>
    <name>L0ACG4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na+/proline symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_1110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1110"/>
    <dbReference type="EnsemblBacteria" id="AFZ70832">
        <property type="protein sequence ID" value="AFZ70832"/>
        <property type="gene ID" value="Calag_1110"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1110"/>
    <dbReference type="eggNOG" id="arCOG01316">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_15_0_2"/>
    <dbReference type="OMA" id="ILSYKSH"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="498" mass="53516" checksum="4642DA2E52E768F0" modified="2013-03-06" version="1">MKFMFGLVGWIVFWVLFAVFVFLGFFGSRWRRGDLSQLHEWALAGRKLGVILVWFLVGADLYTAYTFVAVPSLVYASGAVGFFAVPYVAITFAIAMLFMPILWEKSRQKGYITAADFAGDVFNSKTLAILIALTGIVAELPYIALQIDGMRAVLSVMLLGYSGGKLASEWALIISFIILAAFVYTSGLRGATLGAVFKDVLIWISIIALIVVVPLKYGGFGAAFADAAKIHTFATGLETLKPLFASAFVSLFIGSALALYLYPHAVNGSLSAESASKLRLSTALLPLYGIGLAILALMGILVYSDPAALNITKVLSGLASVPAIAVTAFPDWFAAIILLGIFVGGLVPAAIMAIAQANLLTRNIIKPFKKDLTPKGETEISKWASVVFKFIALAFVFLTPLTYAIQLQLLGGIIILTTLPAVFIGLLTNKLDKYSLIVGWFVSLISSIYLVLLANHFKTLSSSTYLILGHPIYIGIIGLGINLAIVLIGTLIKFAIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACK8</accession>
    <name>L0ACK8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnz</name>
        <name evidence="10" type="ordered locus">Calag_1449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233051.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1449"/>
    <dbReference type="EnsemblBacteria" id="AFZ71154">
        <property type="protein sequence ID" value="AFZ71154"/>
        <property type="gene ID" value="Calag_1449"/>
    </dbReference>
    <dbReference type="GeneID" id="14212709"/>
    <dbReference type="KEGG" id="clg:Calag_1449"/>
    <dbReference type="eggNOG" id="arCOG00501">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_2_0_2"/>
    <dbReference type="OMA" id="IWLTHIS"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="22"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ71154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="300" mass="34400" checksum="8E52CF5DAB1FBEF3" modified="2013-03-06" version="1">MTRWIELTTLGTGGAYPGENRFTASYVIRDWLGNVVLLDVGEGTQYRLRQADIPLTRISTILITHGHGDHINGLPGLLQSMYLNTRNIPLNIIASSDVIKFIKDTLEVEGAHLGFSINLYEINQEGKIEIFNQKGDKINVYWHPSCHSREAYCYTLEWNLRPRINVEEMKRQGIIPGPDVEKYIESNDDKMLIRLNPFRISYTGDTKPCDSIIKCIKDSDVIIHESTFSDDNEKEADQFFHSTGRRAALDAKNSRASLLILSHISSRYEGYEALEIEKQAKEEFKNTILTWDLARFRFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACQ0</accession>
    <name>L0ACQ0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable transcription termination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusA</name>
        <name evidence="8" type="ordered locus">Calag_1503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in transcription termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1503"/>
    <dbReference type="EnsemblBacteria" id="AFZ71204">
        <property type="protein sequence ID" value="AFZ71204"/>
        <property type="gene ID" value="Calag_1503"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1503"/>
    <dbReference type="eggNOG" id="arCOG01760">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131906_0_0_2"/>
    <dbReference type="OMA" id="TDQIKYI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_A">
        <property type="entry name" value="NusA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010212">
        <property type="entry name" value="NusA_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01952">
        <property type="entry name" value="nusA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="KH_5" evidence="7">
        <location>
            <begin position="41"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="149" mass="16919" checksum="3C0E6B25F86C7134" modified="2013-03-06" version="1" precursor="true">MQVMENSSSDRIDLEELRYLSLFQDLTGAMAYRCISDNESNRVFYLVSKNDLGKAIGKDGKNVKSLSKILNKNIEIVEYSDKIEQMAKNLFPGITILKVDLIDKDNTKALYIKVKDDEKGKAIGKEGKNVKRAKIILSKLYNIEKVVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACU6</accession>
    <name>L0ACU6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70967">
        <property type="protein sequence ID" value="AFZ70967"/>
        <property type="gene ID" value="Calag_1250"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1250"/>
    <dbReference type="HOGENOM" id="CLU_1040518_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="267" mass="29585" checksum="5A9449B500B617CE" modified="2013-03-06" version="1">MASLMEKDILAYYNYTNNNIYINVSGMAYPYSYYISGISIILKNGSYIVYDSYSGGSNSLQIIVKGANNRITTYNSLPVSLTPNSSALIIVSNIKSNPIGISISVVNGKSIASIPVENVQQIISALKTSGVVYIVPPVTKIITNKYFNVTFNINFINSTSVHVIGNGQVKGDDYNWSVSFDEQTKSNIGYVYKKGTNDNTINFSNGTNITFTSVPSGYYYYYNISDLYFYNNTQIDYICYPNPSSGILFVNQNTNVSITYTCPKPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD06</accession>
    <name>L0AD06_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1310"/>
    <dbReference type="EnsemblBacteria" id="AFZ71022">
        <property type="protein sequence ID" value="AFZ71022"/>
        <property type="gene ID" value="Calag_1310"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1310"/>
    <dbReference type="eggNOG" id="arCOG01296">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_3_2"/>
    <dbReference type="OMA" id="VDNFPGY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="331" mass="36443" checksum="B9820A1BB1C599A2" modified="2013-03-06" version="1">MKNLSLRLGTKISRPPKGELYDVLIVGGGPAGFSAAVYASRFLLKSAVVSEDIGGQLNLTDVVDDYPGTLSIKASELVSRFRDHAEKLFKVPVYEFISVKKFDKVDDEFHITGSNGLDVYSKTIILAVGSKRRKLNVPGEDTFTGKGVSYCSICDAPLYKGKDSVVVVGGGDAALEGALLLSGYVKKVYLVHRRDQFRAKPFYVNQVLNKKNIEILYNSVVKEIKGDNFVKSAVVLNKENNNEREINIDGIFIEIGFEPPKDWYQSLGLETDEAGYIKVDDWMRTNIEGVFAAGDATSKWKGFRQIVTAAASGSIAAYSAYTYLTEKSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD16</accession>
    <name>L0AD16_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232929.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1321"/>
    <dbReference type="EnsemblBacteria" id="AFZ71032">
        <property type="protein sequence ID" value="AFZ71032"/>
        <property type="gene ID" value="Calag_1321"/>
    </dbReference>
    <dbReference type="GeneID" id="14212581"/>
    <dbReference type="KEGG" id="clg:Calag_1321"/>
    <dbReference type="eggNOG" id="arCOG00447">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_1_1_2"/>
    <dbReference type="OMA" id="YKHVWVF"/>
    <dbReference type="OrthoDB" id="83858at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="352" mass="38800" checksum="8FBC77EEC0C935BA" modified="2013-03-06" version="1">MSSEPKKDCNICPEWDCQNVNDFKNVWVVGEVDENGISEPSLQMLTPANKIASKLNTKIVGLLVGYNVKKYAKEFIEYGADEVIVLDDERLSMYSPHIYARTIAELAKKYKPAVIFISATMKGRELGPYVANTLRAGITADCTDFDVDEKTKDVLLIRPPFGAVLLAYIKTPTRRPQIGTARPNVFKLPPRDPNRNGEIIEEKIDYIPKPKARLVSRKLLPINEVPIEKADLIVSGGKGLGNVEGFKLLEELASKMNAAVAGSRKAVDMGWIPHEKQVGQTGKSVKPILYLAVGISGAAQHMFGIREAEVVVAINNDPNAPIFSQADYGIVADYKQVIPALIKEIESLKKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADD0</accession>
    <name>L0ADD0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA family ATPase, CDC48 subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233014.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1410"/>
    <dbReference type="EnsemblBacteria" id="AFZ71117">
        <property type="protein sequence ID" value="AFZ71117"/>
        <property type="gene ID" value="Calag_1410"/>
    </dbReference>
    <dbReference type="GeneID" id="14212670"/>
    <dbReference type="KEGG" id="clg:Calag_1410"/>
    <dbReference type="eggNOG" id="arCOG01308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_3_2"/>
    <dbReference type="OMA" id="WINPPDF"/>
    <dbReference type="OrthoDB" id="2808at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="5">
        <location>
            <begin position="14"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="4">
        <location>
            <begin position="114"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="219"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="492"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="734" mass="81649" checksum="2FF5651449FB97CD" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADF2</accession>
    <name>L0ADF2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH:ubiquinone oxidoreductase subunit 4 (Chain M)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233039.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1435"/>
    <dbReference type="EnsemblBacteria" id="AFZ71142">
        <property type="protein sequence ID" value="AFZ71142"/>
        <property type="gene ID" value="Calag_1435"/>
    </dbReference>
    <dbReference type="GeneID" id="14212695"/>
    <dbReference type="KEGG" id="clg:Calag_1435"/>
    <dbReference type="eggNOG" id="arCOG01539">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_2_2"/>
    <dbReference type="OMA" id="GHMGFVL"/>
    <dbReference type="OrthoDB" id="28394at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="2">
        <location>
            <begin position="146"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="520" mass="57338" checksum="5FAB5D0D3EA076F2" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADJ2</accession>
    <name>L0ADJ2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type 2 DNA topoisomerase 6 subunit B</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Type II DNA topoisomerase VI subunit B</fullName>
            <shortName evidence="4">TopoVI-B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">top6B</name>
        <name evidence="7" type="ordered locus">Calag_1391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TOP6B family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232997.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1391"/>
    <dbReference type="EnsemblBacteria" id="AFZ71100">
        <property type="protein sequence ID" value="AFZ71100"/>
        <property type="gene ID" value="Calag_1391"/>
    </dbReference>
    <dbReference type="GeneID" id="14212651"/>
    <dbReference type="KEGG" id="clg:Calag_1391"/>
    <dbReference type="eggNOG" id="arCOG01165">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006403_1_0_2"/>
    <dbReference type="OMA" id="TRIELEM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00823">
        <property type="entry name" value="TopoIIB_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00322">
        <property type="entry name" value="Top6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005734">
        <property type="entry name" value="TopoVI_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015320">
        <property type="entry name" value="TopoVI_B_transducer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF4">
        <property type="entry name" value="PTHR10871:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09239">
        <property type="entry name" value="Topo-VIb_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006553">
        <property type="entry name" value="TopoVI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01052">
        <property type="entry name" value="top6b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="HATPase_c" evidence="6">
        <location>
            <begin position="35"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="109"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="118"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ71100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="555" mass="63224" checksum="449DC7884C466840" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADL0</accession>
    <name>L0ADL0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233114.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1517"/>
    <dbReference type="EnsemblBacteria" id="AFZ71217">
        <property type="protein sequence ID" value="AFZ71217"/>
        <property type="gene ID" value="Calag_1517"/>
    </dbReference>
    <dbReference type="GeneID" id="14212778"/>
    <dbReference type="KEGG" id="clg:Calag_1517"/>
    <dbReference type="eggNOG" id="arCOG05362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137177_0_0_2"/>
    <dbReference type="OMA" id="DIPEMLW"/>
    <dbReference type="OrthoDB" id="106844at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="130" mass="14350" checksum="4AAE552ACD70E97E" modified="2013-03-06" version="1">MVAEKVISCSGKNVDIASLKQGIVDYLTSQGFKTQTSKESPHGVLIQAQKGGFLRDIIAAERSLNILISGDPNNTIIRIGVGKWIQNLAVTAVETLLLSEIFMFIDIPEMLWNLEVENKLAKEISENFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADN4</accession>
    <name>L0ADN4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribbon-helix-helix protein, copG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233042.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1439"/>
    <dbReference type="EnsemblBacteria" id="AFZ71145">
        <property type="protein sequence ID" value="AFZ71145"/>
        <property type="gene ID" value="Calag_1439"/>
    </dbReference>
    <dbReference type="GeneID" id="14212699"/>
    <dbReference type="KEGG" id="clg:Calag_1439"/>
    <dbReference type="eggNOG" id="arCOG03845">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3002951_0_0_2"/>
    <dbReference type="OMA" id="EQNKRYD"/>
    <dbReference type="OrthoDB" id="126804at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="56" mass="6939" checksum="511F404668698DDF" modified="2013-03-06" version="1">MYEQNKRYDELRIISFRIDTETLYELDKITLKTKSNRSEIIRKAIEEYLKNEIVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7P7</accession>
    <name>L0A7P7_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle 19 kDa protein</fullName>
            <shortName evidence="5">SRP19</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">srp19</name>
        <name evidence="6" type="ordered locus">Calag_0054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SRP19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231744.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0054"/>
    <dbReference type="EnsemblBacteria" id="AFZ69846">
        <property type="protein sequence ID" value="AFZ69846"/>
        <property type="gene ID" value="Calag_0054"/>
    </dbReference>
    <dbReference type="GeneID" id="14211314"/>
    <dbReference type="KEGG" id="clg:Calag_0054"/>
    <dbReference type="eggNOG" id="arCOG01217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169299_1_0_2"/>
    <dbReference type="OMA" id="VIWPAYL"/>
    <dbReference type="OrthoDB" id="121943at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00305">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022938">
        <property type="entry name" value="SRP19_arc-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="PTHR17453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SSF69695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="96" mass="11107" checksum="D1566319A08E0EA5" modified="2013-03-06" version="1">MPKEDKYIIWPCYIDSAISKNNGRKISKGKAVLKPSIEEIINAAKKLGFNAVVEEKKYPRLWIDQTKRIVIPKVSKKRDLLIKISEEIIKARQKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0A859</accession>
    <name>L0A859_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231919.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0239"/>
    <dbReference type="EnsemblBacteria" id="AFZ70021">
        <property type="protein sequence ID" value="AFZ70021"/>
        <property type="gene ID" value="Calag_0239"/>
    </dbReference>
    <dbReference type="GeneID" id="14211499"/>
    <dbReference type="KEGG" id="clg:Calag_0239"/>
    <dbReference type="eggNOG" id="arCOG13717">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1318467_0_0_2"/>
    <dbReference type="OMA" id="SINCANT"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="213" mass="24384" checksum="E605F5D507A3B285" modified="2013-03-06" version="1">MKITNSFIENSINCANTIIKNCLENKLRCRDPPLSTSRLLRTLGLSEYQERNYWKIAKEVSKLGNIPIYKYSNIEFDLITEVRNEKIYSVNNIPVDYIDCRFLEDKCKITNKGFAFYVYINGNIEKSSLKINAINILNLLAMHNTDLAFGLLSSISGVIYNGNAGFEALLENVLRLIKIQIVNLILPKTPQNLNELLKLSKLLRDLSKQFGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8E2</accession>
    <name>L0A8E2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232016.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0341"/>
    <dbReference type="EnsemblBacteria" id="AFZ70118">
        <property type="protein sequence ID" value="AFZ70118"/>
        <property type="gene ID" value="Calag_0341"/>
    </dbReference>
    <dbReference type="GeneID" id="14211601"/>
    <dbReference type="KEGG" id="clg:Calag_0341"/>
    <dbReference type="HOGENOM" id="CLU_463544_0_0_2"/>
    <dbReference type="OrthoDB" id="143405at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="588" mass="67858" checksum="30802E158A00C3AA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8G2</accession>
    <name>L0A8G2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor 2, alpha subunit (EIF-2alpha)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0374"/>
    <dbReference type="EnsemblBacteria" id="AFZ70148">
        <property type="protein sequence ID" value="AFZ70148"/>
        <property type="gene ID" value="Calag_0374"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0374"/>
    <dbReference type="eggNOG" id="arCOG04107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033458_0_2_2"/>
    <dbReference type="OMA" id="DVNEHQR"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="PTHR10602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="SSF110993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="SSF116742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="13"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="267" mass="31070" checksum="ABF5C680667C76D1" modified="2013-03-06" version="1">MALKNRKEMPDIGEIVVGTIKEIHDFGAYMVIDEYNDLRAFLPWSEVATKAVKNINEVIKENQKLAVKVIRVYRNKGQVDVSLKRVNDNERKRKMMYWKRTLKAVNLILMAAKQINKSEDEAYKEVVWHLEDYFGDAMSGLEAINLEGKDALKRAKIPIEWHDILLDYAKKYVEVKHVQISGYFNLKSLESDGIDRIRKILLDIKEEVKKYDGIDIKIYTIGSPKYRIDLIGPDYKTLENVIEKLISKGEKLAKDLKVEYSFERVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8H0</accession>
    <name>L0A8H0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-ribofuranosylaminobenzene 5'-phosphate synthase</fullName>
            <shortName evidence="1">Beta-RFA-P synthase</shortName>
            <ecNumber evidence="1">2.4.2.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48556"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:82767"/>
            <dbReference type="EC" id="2.4.2.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-RFA-P synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.54" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232056.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0385"/>
    <dbReference type="EnsemblBacteria" id="AFZ70158">
        <property type="protein sequence ID" value="AFZ70158"/>
        <property type="gene ID" value="Calag_0385"/>
    </dbReference>
    <dbReference type="GeneID" id="14211645"/>
    <dbReference type="KEGG" id="clg:Calag_0385"/>
    <dbReference type="eggNOG" id="arCOG01026">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061764_0_0_2"/>
    <dbReference type="OMA" id="RLNGAWY"/>
    <dbReference type="OrthoDB" id="109639at2157"/>
    <dbReference type="UniPathway" id="UPA00065"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004422">
        <property type="entry name" value="RFAP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF6">
        <property type="entry name" value="PTHR20861:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004884">
        <property type="entry name" value="Sugar_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="307" mass="34982" checksum="95936D59F446392D" modified="2013-03-06" version="1">MPEKVFVETGSRLHAGFYYAGNEWNVKWGSAGFYIKDPSFIAEFSYGQNEFIGPDFIKKKVERISELLKINNYRVKVLSYIPEHIGLGSGTQIELAIINAFKKLFNLNVNINEIINEMNIAKYSGTGYLLFYNGGFVADAGRPENGEPKVLIHHNIPEKWRFVYVTPDLKKGLDYNQEEKILKNPWEPSEGVKRLMSYGLLRLASGIAREDIEDALEGLRMIQEGTGLYFSKTQGGSYREDLSKIVSELWRSRMIVAQSSWGPTLYTISREDEAEGDADLIKSVLHELRINGKVYITQPRNIGFTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8L3</accession>
    <name>L0A8L3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232106.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0440"/>
    <dbReference type="EnsemblBacteria" id="AFZ70208">
        <property type="protein sequence ID" value="AFZ70208"/>
        <property type="gene ID" value="Calag_0440"/>
    </dbReference>
    <dbReference type="GeneID" id="14211700"/>
    <dbReference type="KEGG" id="clg:Calag_0440"/>
    <dbReference type="eggNOG" id="arCOG13728">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1648211_0_0_2"/>
    <dbReference type="OMA" id="ITKINLR"/>
    <dbReference type="OrthoDB" id="141062at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="163" mass="17873" checksum="A5719094429D9AC2" modified="2013-03-06" version="1">MSSVDEIKNIDNLILPLGQLSDSEAENLISEIVNLLSIAGNQNADIKVQFSTYAGMIYDELITKINLRLYAQKALKVIGYPLADSVELIDCLGESAIKELLLSAAKILSNENAEFDQEVLDIYSDCLGWDKKPSELDKETISIAIFVSFTGALNKWLNSLGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Q7</accession>
    <name>L0A8Q7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV leader peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231702.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0008"/>
    <dbReference type="EnsemblBacteria" id="AFZ69804">
        <property type="protein sequence ID" value="AFZ69804"/>
        <property type="gene ID" value="Calag_0008"/>
    </dbReference>
    <dbReference type="GeneID" id="14211269"/>
    <dbReference type="KEGG" id="clg:Calag_0008"/>
    <dbReference type="eggNOG" id="arCOG02298">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1269859_0_0_2"/>
    <dbReference type="OMA" id="DMWASIF"/>
    <dbReference type="OrthoDB" id="78048at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="2">
        <location>
            <begin position="13"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="217" mass="24607" checksum="78936F794873E574" modified="2013-03-06" version="1" precursor="true">MIILKVMQYFLIMLAFAIFIPASILDIKYREVPLWLWYVGSKIGIVFSLISFSFYYSIQTLVIYYLISIFSVLGLFIAYIIGHMGAGDMWASIFLALSLPINPFGGIFPPIILTLLIASILELITRTFLTLRECKGFNKRCFSAAPIKARDLLSMKKYKWYFAQTSTKNISVDEPHETIIEECNGNLDNIVWAQPGLPYILFILISLPVSLILGAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8R2</accession>
    <name>L0A8R2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232129.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0465"/>
    <dbReference type="EnsemblBacteria" id="AFZ70231">
        <property type="protein sequence ID" value="AFZ70231"/>
        <property type="gene ID" value="Calag_0465"/>
    </dbReference>
    <dbReference type="GeneID" id="14211725"/>
    <dbReference type="KEGG" id="clg:Calag_0465"/>
    <dbReference type="eggNOG" id="arCOG00310">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_1_2"/>
    <dbReference type="OMA" id="RVVVYFY"/>
    <dbReference type="OrthoDB" id="98508at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="4">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="152" mass="17250" checksum="BEE79DE5D25DB53E" modified="2013-03-06" version="1">MLKEGNLAPDFELTSNNGEKVKLSNFKGRFVVLYFYPRAMTAGCTREGLRFNELYDDFKKLNVEILGVSTDSVDKIKKFSERYGFKFKLLSDAEGYVVGLYGVKKDSTSLAAERTTFIIDPNGIIVKILKNIRPAEKHADQSLEELKKIINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8S1</accession>
    <name>L0A8S1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GMP synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GMP synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Calag_0509</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232171.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0509"/>
    <dbReference type="EnsemblBacteria" id="AFZ70273">
        <property type="protein sequence ID" value="AFZ70273"/>
        <property type="gene ID" value="Calag_0509"/>
    </dbReference>
    <dbReference type="GeneID" id="14211769"/>
    <dbReference type="KEGG" id="clg:Calag_0509"/>
    <dbReference type="eggNOG" id="arCOG00085">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_2"/>
    <dbReference type="OMA" id="KRKIIGH"/>
    <dbReference type="OrthoDB" id="22053at2157"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 11" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="12">
        <location>
            <begin position="194"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="221"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ70273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="507" mass="56645" checksum="C802C4EE8398A67B" modified="2013-03-06" version="1">MDYIAIVDLGSQYTHLIQKRLTYINVNSILTSEFNQDVYNAKAVIVSGSPMSALRDDIKEIQENIGNLINMGKPILGICFGHQLLSLMFGGKIIDNPEYGRTRIFINKRNELLYNIDSPAEVWMSHGDCVVEAGDAEINAISEKGCISAIKVPNMNVYGVQFHPEVTHTRNGELIFKNFAQSIGFDIKEISANERVSNYYAYELNNIKSLYKGGRVVSAVSGGIDSTVATYIVMKAIGSNNVIPVLIDHGLFRINEVEESKINLEKAGINPIYIDASEEFLNKLEGITSCEERRKIIGELFAKKLNEVITKENASYLIQGTIYPDVIESGKTKYSQKIKSHHNVGGIPKWFNIDIIEPLRGLYKDEIRELAKIIGIPKEILNRHPFPGPGLAVRIIGKFTNEKLNLLKKADKIVNDVLKAKGIYNNLWQSVVTISESWVGVKGDEREEGYIINVRLVNSDDGMTADYYLPPNNVIDEISNRITNEVKKITAVSFITSTKPPTTIEPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8T8</accession>
    <name>L0A8T8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231732.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0042"/>
    <dbReference type="EnsemblBacteria" id="AFZ69834">
        <property type="protein sequence ID" value="AFZ69834"/>
        <property type="gene ID" value="Calag_0042"/>
    </dbReference>
    <dbReference type="GeneID" id="14211302"/>
    <dbReference type="KEGG" id="clg:Calag_0042"/>
    <dbReference type="eggNOG" id="arCOG01469">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096331_0_0_2"/>
    <dbReference type="OMA" id="AWINGWI"/>
    <dbReference type="OrthoDB" id="92857at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="21"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ69834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="244" mass="27593" checksum="848E78AAEF124ED1" modified="2013-03-06" version="1">MRTSKFNWRFVLAFIWFYGYSSIKRGYYYVLSYLALPLSLLFFIYIVSKGHLVQYAILGGIISIITSNALTAIGDTSFFKLELKLQELLIAADVSPIEYLLGIGLGNLLYSLPGLFVYFVLGFLYKIFSLSLLGLTILTLIIVMVAATSLAYMTGSRVSHMRNSWGVGSLLSVILTMLPPLYYPYTFLPKIALYPLILSPATPASIFLQDFMTKRIINYYSFLILLAETIIYLLLALKLGKWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8W6</accession>
    <name>L0A8W6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative metal-dependent hydrolase (Urease superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232221.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0564"/>
    <dbReference type="EnsemblBacteria" id="AFZ70323">
        <property type="protein sequence ID" value="AFZ70323"/>
        <property type="gene ID" value="Calag_0564"/>
    </dbReference>
    <dbReference type="GeneID" id="14211824"/>
    <dbReference type="KEGG" id="clg:Calag_0564"/>
    <dbReference type="eggNOG" id="arCOG00893">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_985571_0_0_2"/>
    <dbReference type="OMA" id="CAVQLHT"/>
    <dbReference type="OrthoDB" id="47746at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011589">
        <property type="entry name" value="UCP004961"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42206">
        <property type="entry name" value="PTHR42206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="282" mass="32594" checksum="64845A00ACE02899" modified="2013-03-06" version="1">MIFADAHSHINPIKGLGYKISEKFKSNDGWFIAYISSSPWDYFDDFNGFDSYEKMINYQINECQKSNEIGVKTACIAGFHPEDIDFLIDKVKMSPSSVLNLGLKVIEYEASLCKEGKLFGIGEVGRQHYKTQSERVAISQIILEKALEYAKDYDCMIHLHLENADTDTVRIIDYSVNKANIRNKKKIVFHHAKPSMLTEIDSLGYSATVYGIDEVLNIVLYNLPPIFMIESDFPDNPSFKKVVYPWELPRKITYFSKKYNINEEYLYKINVDNIEEAYNIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A901</accession>
    <name>L0A901_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232266.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0611"/>
    <dbReference type="EnsemblBacteria" id="AFZ70368">
        <property type="protein sequence ID" value="AFZ70368"/>
        <property type="gene ID" value="Calag_0611"/>
    </dbReference>
    <dbReference type="GeneID" id="14211871"/>
    <dbReference type="KEGG" id="clg:Calag_0611"/>
    <dbReference type="eggNOG" id="arCOG01568">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074283_0_0_2"/>
    <dbReference type="OMA" id="YVVPGFK"/>
    <dbReference type="OrthoDB" id="58155at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="292" mass="33000" checksum="84454EFA15859D09" modified="2013-03-06" version="1">MAEIISIVAIVVTIYLFVNFLAIFIHRLQEYMYVVRDVLYLAAGLLIVRSIGNGIIRSLFPKYRERSLSVGNLVKIVGYIIVIIAVIAFTKISTTVALFGGTVTGLVLGYALQPTLDNLFSGILILTTGFIKPGERVRVINWRLPYQWASNPGYKYFSPDYIIPGYDGKVVEVGLFASSIITDQGYELKITNSHILGGGIIKYQTIWEDNFTGSIRVEIPISDMEAFELHAKKVLSKFDDKASFYLTEQSDKNYLIYLVKISVPKDQNWLQLKDSILRELLSYKNSDKQKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A908</accession>
    <name>L0A908_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase, imidazolonepropionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231807.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0121"/>
    <dbReference type="EnsemblBacteria" id="AFZ69909">
        <property type="protein sequence ID" value="AFZ69909"/>
        <property type="gene ID" value="Calag_0121"/>
    </dbReference>
    <dbReference type="GeneID" id="14211381"/>
    <dbReference type="KEGG" id="clg:Calag_0121"/>
    <dbReference type="eggNOG" id="arCOG00696">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023620_2_2_2"/>
    <dbReference type="OMA" id="GVTICHG"/>
    <dbReference type="OrthoDB" id="44408at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="55"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="420" mass="45599" checksum="7B965546B6670276" modified="2013-03-06" version="1">MGKIALTNCLVFDSTGKPPYKGNILINNGIIEDIGKANEVKFPDDYDVIDLNGKFVMPGLIDAHMHLTGSRSGKIEEDLITPIGVFFARAIKDLESLLNAGFTTIVDAGSILAIQLKEAVNEKTIVGPRIVGAGPVLSQTFGHGDTHYFPVEYVDYRTSKKLTPFMSLICDGEDECRKAARYAFREGADFIKVMASGGVLSQKDRPEYRQFTLNELKAIVDEANAVNKWVHAHAEGKIGIINSAKAGIKVIAHGDMMDEEAANEVLKAGSIVVPTFAIDYALLDKGSEMGVPEWAMKKIKELYEIHIDNARLAYKMGIKLATGTDFSGGLGKHGDNAIEVKLFVDKIGMKNDEALISATKISSIAAGMEKSIGTLEKGKIADIIAINGNPLDDINVITNKDNILLVIKEGEIYKNKLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0A932</accession>
    <name>L0A932_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <shortName evidence="8">AdoMetDC</shortName>
            <shortName evidence="8">SAMDC</shortName>
            <ecNumber evidence="8">4.1.1.50</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="8">S-adenosylmethionine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="8">S-adenosylmethionine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="8" type="primary">speH</name>
        <name evidence="9" type="ordered locus">Calag_0621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="8">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="8"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232274.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0621"/>
    <dbReference type="EnsemblBacteria" id="AFZ70376">
        <property type="protein sequence ID" value="AFZ70376"/>
        <property type="gene ID" value="Calag_0621"/>
    </dbReference>
    <dbReference type="GeneID" id="14211881"/>
    <dbReference type="KEGG" id="clg:Calag_0621"/>
    <dbReference type="eggNOG" id="arCOG00279">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125470_2_1_2"/>
    <dbReference type="OMA" id="VYTCGEH"/>
    <dbReference type="OrthoDB" id="106151at2157"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006557">
        <property type="term" value="P:S-adenosylmethioninamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00464">
        <property type="entry name" value="AdoMetDC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="PTHR33866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="SSF56276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 8" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023295549" description="S-adenosylmethionine decarboxylase beta chain" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023295548" description="S-adenosylmethionine decarboxylase alpha chain" evidence="8">
        <location>
            <begin position="78"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="8">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="8">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="8">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="8">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="8">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="149" mass="17048" checksum="84412CE1701676D3" modified="2013-03-06" version="1">MNLEVNEESRSDVDFIVGKHVYGSLYGLKPEIADDEELIRQTVLDAVKAANATLIQLMSWKIPGIKGGVSVMALVNESHIVIHTWKEYRYATVDVYTCGNHTNPEKAYKLIVERLKPQYYSYNYADRTQFPTSSPVKRDEMRIETATPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A934</accession>
    <name>L0A934_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoesterase, ICC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ69934">
        <property type="protein sequence ID" value="AFZ69934"/>
        <property type="gene ID" value="Calag_0148"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0148"/>
    <dbReference type="eggNOG" id="arCOG01149">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1207663_0_0_2"/>
    <dbReference type="OMA" id="HENFPLI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="232" mass="26885" checksum="23F9D5937E059749" modified="2013-03-06" version="1">MKFLLVSDIHKSNKMFKGINEYFAIEWLLNLIDDIKPDVLISAGDWDEGMSENDFIEIERKVTLITIYGNHENFPLIIPRSIQNGKIYDFEGLKISGLNGLIEVGRTKKNNESHYLTTDDAINIARKINRKLKGSKLNIFISHQPPYLPDLYPNMRKSESSIVMLKLVEMLRPSLFFNGHMTGGCYSYYEFPNGTKYLRVDSSQQFKCYAILTDLTIDVYEEKRKIFSFNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0A954</accession>
    <name>L0A954_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="4">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="4">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">panB</name>
        <name evidence="8" type="ordered locus">Calag_0169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4 7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0169"/>
    <dbReference type="EnsemblBacteria" id="AFZ69954">
        <property type="protein sequence ID" value="AFZ69954"/>
        <property type="gene ID" value="Calag_0169"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0169"/>
    <dbReference type="eggNOG" id="arCOG00584">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_2"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="4 6">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 6 7">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ69954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="275" mass="30730" checksum="F5A6E132B212F901" modified="2013-03-06" version="1">MERKKLTIRDIMKMKNNKKIVAITSYDYPTAKIADEAGVDIILIGDSLGMVILGYPSTLQVGMSEMLIHTKAVCNANPKALVVSDMPFMSYEYSKEKAILNSSKFLRLGADAIKLEGGSEYKEVIKNIVNSGIPVMGHIGLTPQKYKQIGGYRLIGKNYQEAKDLLDDAIQLEDSGIFSLVIEYTAYEVAKRITEKISIPTICIGSGPYCDGQIMVINDILGMGDYSPEFAKRYVDLKSIIRNAISNYKSEVENGKFPEKYWGMKDEDKKKFENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A989</accession>
    <name>L0A989_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231887.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0207"/>
    <dbReference type="EnsemblBacteria" id="AFZ69989">
        <property type="protein sequence ID" value="AFZ69989"/>
        <property type="gene ID" value="Calag_0207"/>
    </dbReference>
    <dbReference type="GeneID" id="14211467"/>
    <dbReference type="KEGG" id="clg:Calag_0207"/>
    <dbReference type="eggNOG" id="arCOG01252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_565759_0_0_2"/>
    <dbReference type="OMA" id="MENSWAL"/>
    <dbReference type="OrthoDB" id="42527at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="1">
        <location>
            <begin position="55"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="482" mass="53014" checksum="C134A1E1F0BFEE0E" modified="2013-03-06" version="1">MGLITKEMKIINSDFLSSDNSGIPFIMNGKSVEIGLKIWKENILDEPYYFVLPNRNEIKNAVNNSLNSENIKSLSIYNRIEEIIEISSKIEKYEENISRIISLETGKSLEQSREEVLSAEKIMENSWALISSSDMNSRDGPISFVSDSNNIINQVKIENGISIVFPSFTSPFFTTISSIIRSIISGLPVIVRPSSYSMISSLSAVSLFSDSSLINDISFIPIRGLTNMDLFDNEDFTYYFYGKKINYKNLFKILSGKFISNCTGRVSVILCNLPENVDLISNSIAKLSLKHSGQACGSISWLISLESIKNEIVESIADRFSQSLVGNPLEGKEVGPLKNKEVADRSTKLINDAIYKGGTLLTGGLTNGRYIEPTLIDNVTKNSEILWTDIEAPVLASTSVSSCSEAISIAKMMSGASAVIVFGSDNIINKIGKTKKGIIIKGSNNIENILNSICYTSGDPINEIPKSPFPGRLGFDKSLIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9A2</accession>
    <name>L0A9A2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Calag_0734</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0734"/>
    <dbReference type="EnsemblBacteria" id="AFZ70478">
        <property type="protein sequence ID" value="AFZ70478"/>
        <property type="gene ID" value="Calag_0734"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0734"/>
    <dbReference type="eggNOG" id="arCOG00905">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044815_1_3_2"/>
    <dbReference type="OMA" id="RPWLIAE"/>
    <dbReference type="OrthoDB" id="90493at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="36"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="207" mass="23496" checksum="CF6A46BDA0E17431" modified="2013-03-06" version="1">MIIMQDDKRIKISNLNELIKSCKKCPLHLSRTNVVLGNGNINTKIMLIGEAPGRNEDLEGIPFVGLAGKLLDSLLNENNIKRDEVYITNVVKCRPPNNRTPNKEEVSSCLPYLIEEINIVKPELILTLGRTAGEAISIIFNYEWEGLEKERKKIREVMFNGTKIKILSTYHPAAALYKPELKELLRDDIKTASKIIGNKHKNLIDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9H5</accession>
    <name>L0A9H5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">MTNA-like protein</fullName>
            <shortName evidence="2">aMTNA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232418.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0779"/>
    <dbReference type="EnsemblBacteria" id="AFZ70521">
        <property type="protein sequence ID" value="AFZ70521"/>
        <property type="gene ID" value="Calag_0779"/>
    </dbReference>
    <dbReference type="GeneID" id="14212039"/>
    <dbReference type="KEGG" id="clg:Calag_0779"/>
    <dbReference type="eggNOG" id="arCOG01123">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_2_2"/>
    <dbReference type="OMA" id="RLWVDET"/>
    <dbReference type="OrthoDB" id="54988at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="365" mass="40976" checksum="5CF695E3664C65DF" modified="2013-03-06" version="1">MEDIRNELDKLEEYLKIKPLYWDFDKGEFVWIDTRLIPWKELYRSTKDYHRVAQAIKEMEIRGAPAIGVSAAYGLALATIYSNASKVDDLLKDVKEAYNVLASTRPTAYNLFWALNRLWNVILSNYEKNDLEDIKQNVLNEAHRVYIEDIKNNVNMGKYGSKIIENNSRIITHCNTGALATAGFGTALGVIRYAFYEGKSIHVYADETRPLLQGARLTIWELKKEGIPSTLVVDGASGLLFSKNMADLAIVGADRITLTGHVANKIGTFNLALAANYHKKPFYVAAPTSTVHPTENPNDIVIEERSQDEVTNIMGKLNITVDGTEAFNPAFDITPPEIVEGIITEKGIVKKPYLNNFKALLYGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9N5</accession>
    <name>L0A9N5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphatase/phosphohexomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232012.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0337"/>
    <dbReference type="EnsemblBacteria" id="AFZ70114">
        <property type="protein sequence ID" value="AFZ70114"/>
        <property type="gene ID" value="Calag_0337"/>
    </dbReference>
    <dbReference type="GeneID" id="14211597"/>
    <dbReference type="KEGG" id="clg:Calag_0337"/>
    <dbReference type="eggNOG" id="arCOG02293">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_3_2"/>
    <dbReference type="OrthoDB" id="93004at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="215" mass="24388" checksum="25C17DD32AF9754C" modified="2013-03-06" version="1">MNIKGIISDLDDTLAQTQALHFKAWENTAEKFGVKINLNNKIDLNKFWGLRDIDFLKGFAKEKNISLDQNQITYILSVKNEEYKKLVLSLKPDYCTLYLINIINKYKLKFAIVTSSMRNDALAVLNRLNIRYDLLITSDEVKNVKPDPEPVNLAINGLNLSSNEIIAVGDSIFDAISYKKAGLSKIFLLNIDYEDTIKISSLCELSDIISKEMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9P7</accession>
    <name>L0A9P7_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)</fullName>
            <ecNumber evidence="2">2.5.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl diphosphate synthase</fullName>
            <shortName evidence="2">UDS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl pyrophosphate synthase</fullName>
            <shortName evidence="2">UPP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">uppS</name>
        <name evidence="3" type="ordered locus">Calag_0868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27622"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:60388"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0868"/>
    <dbReference type="EnsemblBacteria" id="AFZ70608">
        <property type="protein sequence ID" value="AFZ70608"/>
        <property type="gene ID" value="Calag_0868"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0868"/>
    <dbReference type="eggNOG" id="arCOG01532">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_1_1_2"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="16"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="217" mass="25408" checksum="DF20D32A9384A43B" modified="2013-03-06" version="1">MKTKNLPIHIGIIPDGNRRWAKRNGMDYFTAYKNGFDNLKRILDNIIDYGIYNASVYVLSYENCIKRSKEELNFLFELSKEGFSYIRQNKKLNENDIAVKVIGDTSITPEFVQNEIQKTEEETKNRKNGFLNLAYCYSGEWEINLLKKGETNLPSLNMKPIDLVIRTGGVRRISGFFPLLVSYAELYFTNMLWPDFNENELKKALKWFSLQQRNFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Q2</accession>
    <name>L0A9Q2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin subunit of nitrite reductase and ring-hydroxylating dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0363"/>
    <dbReference type="EnsemblBacteria" id="AFZ70139">
        <property type="protein sequence ID" value="AFZ70139"/>
        <property type="gene ID" value="Calag_0363"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0363"/>
    <dbReference type="eggNOG" id="arCOG02854">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_5_4_2"/>
    <dbReference type="OMA" id="CPCHHAV"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="115" mass="12760" checksum="1EA5BBE5D5148139" modified="2013-03-06" version="1">MVFRKISVIGKVFERRNSAVVMVEDKPILIVKYNNSLYGMDAICSHMGCGLLTDVTDNIAACPLHGAKFNVITGEMVAPPQIKPEVPCEFKSDSKTPLKTYKVRINNEGFVEIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9R0</accession>
    <name>L0A9R0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231780.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0094"/>
    <dbReference type="EnsemblBacteria" id="AFZ69882">
        <property type="protein sequence ID" value="AFZ69882"/>
        <property type="gene ID" value="Calag_0094"/>
    </dbReference>
    <dbReference type="GeneID" id="14211354"/>
    <dbReference type="KEGG" id="clg:Calag_0094"/>
    <dbReference type="eggNOG" id="arCOG06031">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_955157_0_0_2"/>
    <dbReference type="OMA" id="MWLNRNL"/>
    <dbReference type="OrthoDB" id="39458at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034641">
        <property type="term" value="P:cellular nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046483">
        <property type="term" value="P:heterocycle metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901360">
        <property type="term" value="P:organic cyclic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017004">
        <property type="entry name" value="UCP032676_PqqC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032553">
        <property type="entry name" value="UCP032676_Znf-C2H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PTHR40279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16293">
        <property type="entry name" value="zf-C2H2_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032676">
        <property type="entry name" value="UCP032676_PQQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-C2H2_9" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="TENA_THI-4" evidence="1">
        <location>
            <begin position="68"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="307" mass="36441" checksum="CA2548F567763D38" modified="2013-03-06" version="1">MPICPICRIESRSWDEISDHIYFMANEKSDPDHIMWLNRFVSKNKLSKEELSNRLRNYFDEPKSLPEWIRYRFIEKFYGKNPHLFMILMQNPTRGLLLGYVIEHRHFLQNWVKVLSKIIYNTDKEDVIRYELENIATEYIGYNGKPSHYELLIKMGESLGLSREKILSYEPLPSTKEAISTWRNIAETRPWVETMAAMHSLELAADKTNLKYGAKIHYFNPNILSSNQYNEHVKNFLREGYEADEGHAGEALRLIDNYSQDYLTKINIKVTLLKSWDALDKYLYARIQRAMEFEPELFEVIRSESYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9S3</accession>
    <name>L0A9S3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232498.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0861"/>
    <dbReference type="EnsemblBacteria" id="AFZ70601">
        <property type="protein sequence ID" value="AFZ70601"/>
        <property type="gene ID" value="Calag_0861"/>
    </dbReference>
    <dbReference type="GeneID" id="14212121"/>
    <dbReference type="KEGG" id="clg:Calag_0861"/>
    <dbReference type="eggNOG" id="arCOG05930">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_591356_0_0_2"/>
    <dbReference type="OMA" id="AGYHYET"/>
    <dbReference type="OrthoDB" id="110059at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="456" mass="51672" checksum="16DA26B468583A7E" modified="2013-03-06" version="1">MDYFYYLLAINLSLLTFYIGVLIIALPIPIKGLKKWGSSLIKDSILSFIIIISIYFIYNYINNLANSLGGSWGYFNLWYSNAISLSITIKAFLLEILAVSSKIPLASQIRSLVSPINDALTAEIIFLAGLWGIYFIVNSLGQTLLMFGIVLYSIPFRIARDAGAWFISFILVFSIGLQLLPVFTTNIAESAGVNLNGQAMSLGLTFVNAKATYRGNAIKNSLIYVYTYNNSYQQIALYKTDNNGEIVSPYYGDEIPLPSEVPSYIFSVIDGVAFKLYPYPFYPYNLTFNNQGFNLYTNNILYENENYTLAFEVNGNYSSYILGNKVYIYGNGGYVEIRALNGCVSNLTHINFVEYFGEWNFYNLKGYYYKFVPNNQSNSYLIFTINNCNVSQINVKYIDYANNYLGLENILTPSILEYLLLYYITVPLMYFSLLISITYGLARLLGGRRGIIPRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9U2</accession>
    <name>L0A9U2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232560.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0932"/>
    <dbReference type="EnsemblBacteria" id="AFZ70663">
        <property type="protein sequence ID" value="AFZ70663"/>
        <property type="gene ID" value="Calag_0932"/>
    </dbReference>
    <dbReference type="GeneID" id="14212192"/>
    <dbReference type="KEGG" id="clg:Calag_0932"/>
    <dbReference type="eggNOG" id="arCOG13659">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1187734_0_0_2"/>
    <dbReference type="OMA" id="VINYMEL"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="233" mass="26705" checksum="FFFCC2512C56BD0B" modified="2013-03-06" version="1" precursor="true">MKLKELGILLLSISIPVMVFSIFVINYMELFYVFLGIFIIGLASFSISDNYIFPYVIREMIESSALNIEAILEEFDARGKGIYLNKEGRDIAFIPYEENEYFEKDHVNKIISSPLRILNERGVTVFIPTPPINKEGDERDESFLKKILIEHLDLADDVKLIKNDVENKSELIINIINPKGRYLNIPRYEKCLGHLESSIALSSLSKYYGKPIHFVREAKNQNGIILEGEILNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9V9</accession>
    <name>L0A9V9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Copper/silver-translocating P-type ATPase,heavy metal-translocating P-type ATPase, Cd/Co/Hg/Pb/Zn-transporting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232533.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0896"/>
    <dbReference type="EnsemblBacteria" id="AFZ70636">
        <property type="protein sequence ID" value="AFZ70636"/>
        <property type="gene ID" value="Calag_0896"/>
    </dbReference>
    <dbReference type="GeneID" id="14212156"/>
    <dbReference type="KEGG" id="clg:Calag_0896"/>
    <dbReference type="eggNOG" id="arCOG01576">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02763">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_0_2"/>
    <dbReference type="OMA" id="HWMLPAW"/>
    <dbReference type="OrthoDB" id="21472at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="739"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="6">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="757" mass="83439" checksum="C71ABA10E23B8CF3" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9W1</accession>
    <name>L0A9W1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0902"/>
    <dbReference type="EnsemblBacteria" id="AFZ70641">
        <property type="protein sequence ID" value="AFZ70641"/>
        <property type="gene ID" value="Calag_0902"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0902"/>
    <dbReference type="eggNOG" id="arCOG02019">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_1_3_2"/>
    <dbReference type="OMA" id="QRPGHVP"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="167"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="293" mass="34141" checksum="F9BEABCD356A5A1D" modified="2013-03-06" version="1">MINVGELKEIVDNKWLLDHLKDENVRVIEVDYDPNTAFNIWHIPGSVLIRWREDLRHKVLRDFLEPEEFERLMESKGVNNNTTIILYGDYNNWFAVYAFWLFKAYGHDDVRILNGGRTKWAKDDLPIENGDKETKYKEGKYKINKVDWGSHRVFFWELLQKVTKNEIGKTTILVDVRSPKEFSGEIRAPPEYADEQTQVGGHIPGAISFPWSQAVNPDTGEFKSKEELERLFENAGIKKDKEVITYCRIGERASHTWFVLKYLLNYPSVRVYDGSWAEWGNIVGAPIKKGTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Y8</accession>
    <name>L0A9Y8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ubiquinone-dependent succinate dehydrogenase or fumarate reductase, flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_0990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232610.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0990"/>
    <dbReference type="EnsemblBacteria" id="AFZ70713">
        <property type="protein sequence ID" value="AFZ70713"/>
        <property type="gene ID" value="Calag_0990"/>
    </dbReference>
    <dbReference type="GeneID" id="14212250"/>
    <dbReference type="KEGG" id="clg:Calag_0990"/>
    <dbReference type="eggNOG" id="arCOG00571">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_2_2"/>
    <dbReference type="OMA" id="HWEWHMF"/>
    <dbReference type="OrthoDB" id="8547at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="9">
        <location>
            <begin position="7"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="10">
        <location>
            <begin position="455"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="580" mass="64475" checksum="C4B4C33585DA5D3F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA34</accession>
    <name>L0AA34_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231885.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0205"/>
    <dbReference type="EnsemblBacteria" id="AFZ69987">
        <property type="protein sequence ID" value="AFZ69987"/>
        <property type="gene ID" value="Calag_0205"/>
    </dbReference>
    <dbReference type="GeneID" id="14211465"/>
    <dbReference type="KEGG" id="clg:Calag_0205"/>
    <dbReference type="eggNOG" id="arCOG00284">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_453183_0_0_2"/>
    <dbReference type="OMA" id="KASMYWE"/>
    <dbReference type="OrthoDB" id="13246at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033186">
        <property type="entry name" value="HerA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05872">
        <property type="entry name" value="DUF853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="192"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="DUF853" evidence="2">
        <location>
            <begin position="572"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="706" mass="80640" checksum="29D6BFD4F6079FB7" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA41</accession>
    <name>L0AA41_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase (AAA+ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232623.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1004"/>
    <dbReference type="EnsemblBacteria" id="AFZ70726">
        <property type="protein sequence ID" value="AFZ70726"/>
        <property type="gene ID" value="Calag_1004"/>
    </dbReference>
    <dbReference type="GeneID" id="14212264"/>
    <dbReference type="KEGG" id="clg:Calag_1004"/>
    <dbReference type="eggNOG" id="arCOG03169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061108_0_0_2"/>
    <dbReference type="OMA" id="SEMPHPV"/>
    <dbReference type="OrthoDB" id="56889at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="357" mass="42334" checksum="E6EE641F194D034E" modified="2013-03-06" version="1">MLFDITPKHNRKDFFDREEEIEKLKELRTPILLVLGLRRTGKSSLIRISLNELNLPYIYLDLRMFEQNNYLSYKEFSLELQNEINKLANKFPYLIDFLKEIQGIKIFGNEIKFNWKKKERPSFSSILSAMEKIRKKVIIVLDEAQELIKLKGINILPSLAYAYDNLKNIKIILSGSEMGMLYEFLKIDDPNSPLYGRAFSTIELKPFNREKAIEFLKRGFEEINIDFKDYETVYEKIGGIPGWLTYFGFTYMEKKDLEESINLTLEYAKKLIIKEFNNFLIGREVARKRYETIMNLLKECKTWSDVKKALELEEGIEISDSEVYNYLMQLMKHSWIKKENRNYCVSEPLISQAFRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA47</accession>
    <name>L0AA47_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232675.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1056"/>
    <dbReference type="EnsemblBacteria" id="AFZ70778">
        <property type="protein sequence ID" value="AFZ70778"/>
        <property type="gene ID" value="Calag_1056"/>
    </dbReference>
    <dbReference type="GeneID" id="14212316"/>
    <dbReference type="KEGG" id="clg:Calag_1056"/>
    <dbReference type="eggNOG" id="arCOG13704">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_648296_0_0_2"/>
    <dbReference type="OMA" id="YKENFIA"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="423" mass="48334" checksum="7DEA1E25DC989E40" modified="2013-03-06" version="1" precursor="true">MLSNRLLAIAIIFSFFILSSFMFSIYGINNKTDQAVLVKTNMSMLYYEPYRNPMIVFSNNSKTIIVNRKQFEINGLNSISACSYKENFIALSGYYNNIPSIAIFNGSNYTIYLLGLHSSPNYIYCLNNGIVFTGLNNINPYIAFLNFSNNQIKLYQVDTYLGTPSSLYFYNNTFIITFNNNNVLLFKNNSYVISFPSSISIDSIFAYNSLYFAGSISNNTTNGFLFNSNNRSYIIGLNNYQGFIGAGVDNYNGYSLLYRPYSTWSYLITIIENKYVYTTMIGLSYPFTLNYEGHYDKGLWFTGEMTIGNNDYQAGFYINGTLNGDIGYKLPIGYTLSNDPIVSKGFIKEINISYQKTYVNTTKINIQFNKTTGSPIITNDLKIEYLNFYINKYIILGESLLVSIFISLIIYCVLAKNYNWNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA48</accession>
    <name>L0AA48_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable GTP 3',8-cyclase</fullName>
            <ecNumber evidence="9">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">moaA</name>
        <name evidence="11" type="ordered locus">Calag_0539</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232197.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0539"/>
    <dbReference type="EnsemblBacteria" id="AFZ70299">
        <property type="protein sequence ID" value="AFZ70299"/>
        <property type="gene ID" value="Calag_0539"/>
    </dbReference>
    <dbReference type="GeneID" id="14211799"/>
    <dbReference type="KEGG" id="clg:Calag_0539"/>
    <dbReference type="eggNOG" id="arCOG00930">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_0_1_2"/>
    <dbReference type="OMA" id="IEFMPIG"/>
    <dbReference type="OrthoDB" id="18533at2157"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_A">
        <property type="entry name" value="MoaA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013485">
        <property type="entry name" value="MoaA_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02668">
        <property type="entry name" value="moaA_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="9"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="264"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="346" mass="39121" checksum="863ACDA3DCCE7CD1" modified="2013-03-06" version="1">MLEKRLIDAYGRPLENLRIAVTRECNYNCIFCHLEGDPIGKPQKIGTMPPELTPEDYSIVAEAASKIGITGFKLTGGEPLVRNDIVDIVHNIRKYAQNSDISMTTNGYLLEFYAKKLRDVGLNRVNISIHSLNRETYYKITGVDGLEKALNGLDEALKYNLKVKINASIVNGLNNNEVIELIKFASDKKVTLQLIELQPINAGSRQFNSLHYPLSLIEDMLIKNGAKVINRKLHNRPIYIMPDGTTVEMVKSYNNPIFCAGCMRVRLLADGTLTPCINWRKPGVSLLPRIRNKPREVAIKNAIDAFIEVNTLRRPYTLYNINTNQYITNNDGARLVLPKKSIKFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA55</accession>
    <name>L0AA55_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="5">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231905.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0225"/>
    <dbReference type="EnsemblBacteria" id="AFZ70007">
        <property type="protein sequence ID" value="AFZ70007"/>
        <property type="gene ID" value="Calag_0225"/>
    </dbReference>
    <dbReference type="GeneID" id="14211485"/>
    <dbReference type="KEGG" id="clg:Calag_0225"/>
    <dbReference type="eggNOG" id="arCOG04184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_1_0_2"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="OrthoDB" id="94889at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="195" mass="22302" checksum="2C2E5C055FCA6783" modified="2013-03-06" version="1">MSGKEEQFGKLSICIVSQNEGKIKEIQNILDNFNIKLKKCNAEKIEIQDEDIDKIAIYAALNAYKSVKEPLLVDDSALYIRSLNNFPGAYTNFVYKTIGIKGILKLMEGINDRFAFFKTSLVYIDENGYKLFNGIVEGNIAYEPRGKHGFGFDPIFIPMNCNKTFSEMDINEKNNYSHRSKAVNEFAKWIITKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA62</accession>
    <name>L0AA62_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Archaetidylinositol phosphate synthase</fullName>
            <shortName evidence="1">AIP synthase</shortName>
            <ecNumber evidence="1">2.7.8.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol = CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:36823"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:74004"/>
            <dbReference type="ChEBI" id="CHEBI:74006"/>
            <dbReference type="EC" id="2.7.8.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.39" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232648.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1029"/>
    <dbReference type="EnsemblBacteria" id="AFZ70751">
        <property type="protein sequence ID" value="AFZ70751"/>
        <property type="gene ID" value="Calag_1029"/>
    </dbReference>
    <dbReference type="GeneID" id="14212289"/>
    <dbReference type="KEGG" id="clg:Calag_1029"/>
    <dbReference type="eggNOG" id="arCOG00670">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080384_1_0_2"/>
    <dbReference type="OMA" id="DGNMARQ"/>
    <dbReference type="OrthoDB" id="115624at2157"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02242">
        <property type="entry name" value="AIP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044270">
        <property type="entry name" value="AIP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="193" mass="21265" checksum="81406ED3D971EBF7" modified="2013-03-06" version="1">MLGKLRKYVNEILPKTVGKYLSKIGLTPNAATTIGFLFAILAPTLAYFKFFIAIPIMIVLSGLMDVVDGAIARATNKTTKFGAYLDSLTDRISDMLFFLALIFEGLNPYLSIIALGFSEIVSYARSKGELLGIKMEGIGLLERSERLILLFVASILALLKYYLVGNIIIVIIAILGAITVYQRSYRVKKALND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA92</accession>
    <name>L0AA92_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcription activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232242.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0587"/>
    <dbReference type="EnsemblBacteria" id="AFZ70344">
        <property type="protein sequence ID" value="AFZ70344"/>
        <property type="gene ID" value="Calag_0587"/>
    </dbReference>
    <dbReference type="GeneID" id="14211847"/>
    <dbReference type="KEGG" id="clg:Calag_0587"/>
    <dbReference type="eggNOG" id="arCOG01128">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077537_3_0_2"/>
    <dbReference type="OMA" id="PCMWGYS"/>
    <dbReference type="OrthoDB" id="54038at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034641">
        <property type="term" value="P:cellular nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046483">
        <property type="term" value="P:heterocycle metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901360">
        <property type="term" value="P:organic cyclic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="1">
        <location>
            <begin position="9"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="211" mass="24721" checksum="8DFFE34678B77686" modified="2013-03-06" version="1">MSNFDILRDDVKDLWDKYIRHEFVIKMKEGTLPLDSFKYYMIQDTKYVNIMLKSLLNASSKAPLNKITNILNAIFNTRDKGLEIEKEILEKLNIDDAAIENTGYNLVNYAYTRHLYYNSTIGWDYFLASWAPCMIGYSFVGKFVKGSPNEIYDLWASFYGSKDYENRVETIIDALDDIKLNDGIKNVFRNSVNFEIMFWEAALRKDPTIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA95</accession>
    <name>L0AA95_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molecular chaperone (Small heat shock protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232725.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1106"/>
    <dbReference type="EnsemblBacteria" id="AFZ70828">
        <property type="protein sequence ID" value="AFZ70828"/>
        <property type="gene ID" value="Calag_1106"/>
    </dbReference>
    <dbReference type="GeneID" id="14212366"/>
    <dbReference type="KEGG" id="clg:Calag_1106"/>
    <dbReference type="eggNOG" id="arCOG01832">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1673883_0_0_2"/>
    <dbReference type="OMA" id="RIMRDIM"/>
    <dbReference type="OrthoDB" id="100198at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="54"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="159" mass="18761" checksum="ECCA0940B3853FB8" modified="2013-03-06" version="1">MSYDYFENLRKRMLKMYRDIMRETDEIDAWFESLFDDLELSLNPSKMFNERLYETSNGYITPIISMHNLGDELLITIDLPGSDPNTIDIELLPNKITIEAQIKEEVVKNAFRQAYWARKINKYKGTYSIPFLIDPKTAKVSKKNGMIIIRVKYQGKNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAA3</accession>
    <name>L0AAA3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OB-fold nucleic acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0597"/>
    <dbReference type="EnsemblBacteria" id="AFZ70354">
        <property type="protein sequence ID" value="AFZ70354"/>
        <property type="gene ID" value="Calag_0597"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0597"/>
    <dbReference type="eggNOG" id="arCOG01510">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110881_2_0_2"/>
    <dbReference type="OMA" id="AWTTSYR"/>
    <dbReference type="OrthoDB" id="111719at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="2">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="169" mass="18421" checksum="12B65056B7002FEB" modified="2013-03-06" version="1">MSEGNRKVSDLREGEDNVSIKVRVLSVDEPKVIHTKRGDRTISEAIVGDESGRIKLTMWGNQAGKINEGDAIELKGAWTTSFKGDVQLNIGSRGEINKIDEGSLPKPEDIPENTPKASESSSRSYGRSRGGYRRGGYGGRGYRRDRGGYSSSFGSSEEGEESSDSEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAF4</accession>
    <name>L0AAF4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative endoIII-related endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0658"/>
    <dbReference type="EnsemblBacteria" id="AFZ70409">
        <property type="protein sequence ID" value="AFZ70409"/>
        <property type="gene ID" value="Calag_0658"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0658"/>
    <dbReference type="eggNOG" id="arCOG00459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_4_2"/>
    <dbReference type="OMA" id="QIIWYGR"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="7">
        <location>
            <begin position="59"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="235" mass="26608" checksum="9A0C18F07A7B9759" modified="2013-03-06" version="1">MNESSLCELVKMLNRIKGNGKEIYEVLAKNLEINDNDFAPVVAMSKNNNPFSILVSIILSQNTTDKNAIKAFNNLYEKTGLDPEKIVDLGVDNVSEIIRTAGLPKQKSHSIIELAKFVKEKGEKYLLEKDPLQLKNELMRIPGIGEKTSDVFLSFTRNYPVFPVDTHIRRIALRWGLSDKNSYKSISQALIEFFGPDLSNKAHKLLITFGRIYCKAKNPRCKECFLKEICPSAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAH6</accession>
    <name>L0AAH6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231990.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0313"/>
    <dbReference type="EnsemblBacteria" id="AFZ70092">
        <property type="protein sequence ID" value="AFZ70092"/>
        <property type="gene ID" value="Calag_0313"/>
    </dbReference>
    <dbReference type="GeneID" id="14211573"/>
    <dbReference type="KEGG" id="clg:Calag_0313"/>
    <dbReference type="eggNOG" id="arCOG00132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_60_4_2"/>
    <dbReference type="OMA" id="WESNLSV"/>
    <dbReference type="OrthoDB" id="22281at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="156"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="362" mass="40023" checksum="C98B53A59BFD08F7" modified="2013-03-06" version="1">MEDINKLTIISFIRTFSISIINPYIGLALNQNYKLPIYLVGLYYLGYTLATALGYIFGGYLADFIGRRNAMIISTIMASIFLALSLFNLSLFVAFMFFFNNAYGSANTTAVGDTSDNLKGLVKSFSRVRIGANAGWAIGPAIGGFLYEKYGFNKIILLASIFSIIAVPFLIKIPNIKGSRKILIKPSKKFSKFLIPSTLTSIIMGQLGLPFVLYVSKIFSISTAGYMFTINGLMVVFFQDFFGRKFAKFNYKYSLALGMFIYSISYLNLIFINKIIELALDIVLLTIAEMIVSPINNAVANAMVESGDRGKYMGLFGLTVGIGRTLGQSLSTELSFSKNIEWGNVSFMALLSSILYLVLIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAM4</accession>
    <name>L0AAM4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0378"/>
    <dbReference type="EnsemblBacteria" id="AFZ70152">
        <property type="protein sequence ID" value="AFZ70152"/>
        <property type="gene ID" value="Calag_0378"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0378"/>
    <dbReference type="eggNOG" id="arCOG08212">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187342_0_0_2"/>
    <dbReference type="OMA" id="YEYEYYT"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="86" mass="9967" checksum="8BC5A295617E832C" modified="2013-03-06" version="1">MIKMVRDRVVMAKELKGKKDVNGKSYEYEYYTLPLNIYVKKHIIEKFGKNFVVEIDENTGVICIKPKPLEDFIGITKCPSPWASNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAP6</accession>
    <name>L0AAP6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UbiD family decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0755"/>
    <dbReference type="EnsemblBacteria" id="AFZ70499">
        <property type="protein sequence ID" value="AFZ70499"/>
        <property type="gene ID" value="Calag_0755"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0755"/>
    <dbReference type="eggNOG" id="arCOG01671">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023348_5_1_2"/>
    <dbReference type="OMA" id="TEGGCCW"/>
    <dbReference type="OrthoDB" id="35356at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="413" mass="45408" checksum="C3B8E5C05ADA7ED4" modified="2013-03-06" version="1">MRFIDEVGSEYCGKLSRDFEVSKILKSKQGSKTAQTFHVENVMQISSGNVVDSKEKVLKALHVNNVEEAYNKLLDSFSKKGELKFVGEPKLKEGSLKDLPFVKFYEKDGGYYLTSSIIISCYEGICNASIHRIMLLNEKEAAVRIVPRHLYYLYNEALKHGEMLPVTVIIGVHPAIVLASSHSPPLGYFELEAASNILGSLEVYNSPIHKNPIPYGTGAIIEGFISEKMADEGPFVEAMGGYDKVRKQPILIANKVYVNPDETSHIILPGGYEHAVLMGFPREASIYNAVSKVVPKVHGVNLTYNSGGWLHAIISIEKNHDGDAKNAILAAFSAHPSLKHVVVVDPDINIYDINDVEWAIATRFQADKNLVIVNNARGSTLDPSAKDGLTSKMGIDATKPINGGIEFERAKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAQ3</accession>
    <name>L0AAQ3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">tRNA (cytidine(56)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="6 10">2.1.1.206</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">tRNA ribose 2'-O-methyltransferase aTrm56</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_1284</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42968"/>
            <dbReference type="Rhea" id="RHEA-COMP:10308"/>
            <dbReference type="Rhea" id="RHEA-COMP:10309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.206"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the aTrm56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.206" evidence="6 10"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232895.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1284"/>
    <dbReference type="EnsemblBacteria" id="AFZ70998">
        <property type="protein sequence ID" value="AFZ70998"/>
        <property type="gene ID" value="Calag_1284"/>
    </dbReference>
    <dbReference type="GeneID" id="14212544"/>
    <dbReference type="KEGG" id="clg:Calag_1284"/>
    <dbReference type="eggNOG" id="arCOG01857">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123709_0_0_2"/>
    <dbReference type="OMA" id="VVHLTMY"/>
    <dbReference type="OrthoDB" id="83050at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00077">
        <property type="entry name" value="tRNA_methyltr_aTrm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002845">
        <property type="entry name" value="tRNA_mtfrase_aTrm56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42197">
        <property type="entry name" value="PTHR42197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01994">
        <property type="entry name" value="Trm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016123">
        <property type="entry name" value="UCP016123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="10">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="186" mass="21450" checksum="B87EEB06F8D1595C" modified="2013-03-06" version="1">MKGLEDLSKIYEKVYVLRLGHRPERDKRITTHVALVSRAFGANGFVLEGICDDKVRDSLLKASKSWGGKIDYICNVDGKEYVKKWREEGGEVINLTMYGINVEDVIDKIIISPKKKLIIVGAEKVERFYYDNSDYNVAIGWQPHSEVAALAIFLDRLFKGRELFYNYRDAPYKIIPSERGKKVERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAR6</accession>
    <name>L0AAR6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232873.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1260"/>
    <dbReference type="EnsemblBacteria" id="AFZ70976">
        <property type="protein sequence ID" value="AFZ70976"/>
        <property type="gene ID" value="Calag_1260"/>
    </dbReference>
    <dbReference type="GeneID" id="14212520"/>
    <dbReference type="KEGG" id="clg:Calag_1260"/>
    <dbReference type="eggNOG" id="arCOG00286">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG05935">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495774_0_0_2"/>
    <dbReference type="OMA" id="GHIMAES"/>
    <dbReference type="OrthoDB" id="33242at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="208"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="535" mass="60871" checksum="BE3D6C2954B52ED0" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAS7</accession>
    <name>L0AAS7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232125.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0460"/>
    <dbReference type="EnsemblBacteria" id="AFZ70227">
        <property type="protein sequence ID" value="AFZ70227"/>
        <property type="gene ID" value="Calag_0460"/>
    </dbReference>
    <dbReference type="GeneID" id="14211720"/>
    <dbReference type="KEGG" id="clg:Calag_0460"/>
    <dbReference type="eggNOG" id="arCOG00947">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04464">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_968382_0_0_2"/>
    <dbReference type="OMA" id="HAPCARR"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="287" mass="33289" checksum="DD85DBA08E05343B" modified="2013-03-06" version="1">MSDKKTLNLPVSAIGISTPEALSLYHYLSGGKVMHILLPSTKPIRCKDFDICEIYKSNFENLREINISSIDNLINKWGADGLILEGCDIKNLINDELLDNIKKQLNIPIGIRIAEPINLYNIDFIVYDHFLDYYTNIDFINYINNFNKYNSWIEVQLYYKEPLLEKFLPLVKVVGKKEIPVHIYLLDNKGGGAVRELYNELKKVNPYVYIHVNLYGEYITYCYNCKKPVAYREEGVLLDLELKGNHCWNCGVELPFNKVISKKTDKMFGRISNGDIIWYDPRAIQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAV6</accession>
    <name>L0AAV6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA damage repair.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nre family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232945.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1339"/>
    <dbReference type="EnsemblBacteria" id="AFZ71048">
        <property type="protein sequence ID" value="AFZ71048"/>
        <property type="gene ID" value="Calag_1339"/>
    </dbReference>
    <dbReference type="GeneID" id="14212599"/>
    <dbReference type="KEGG" id="clg:Calag_1339"/>
    <dbReference type="eggNOG" id="arCOG04269">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039703_0_0_2"/>
    <dbReference type="OMA" id="PVGVWQI"/>
    <dbReference type="OrthoDB" id="17407at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02096">
        <property type="entry name" value="Nre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033167">
        <property type="entry name" value="Nre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006979">
        <property type="entry name" value="Nre_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006978">
        <property type="entry name" value="Nre_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38136">
        <property type="entry name" value="PTHR38136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04895">
        <property type="entry name" value="Nre_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04894">
        <property type="entry name" value="Nre_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nre_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Nre_C" evidence="3">
        <location>
            <begin position="308"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ71048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="412" mass="47172" checksum="0B40BC3927129200" modified="2013-03-06" version="1">MARIPPELCAQCKGYKKLCGLPKCPILEEFRARVNSSLKISNKDVNGSTPPSGIIGEYGYPKVLFHYMVPPGLSGDKAKYTDNPVLWSIKKEPLDNIVKMRSELVSATIMVDINRPWELYQNEIGLAIISERPVDSEVLLKKEPLPKLSFDGITKPIGPKAPAEKIIVRDNPKLNITTEKIIWDDLKAEKAIWKIYSSGIDIYTIQNMLSLGFLGKVKNRRLVPTRWSITAVDDIISNELRKKIRDFNEINAIMAFEGEYLSNRFLIIFIPGEGSFEWIEVWHPSSIWTKYATKPIIDKVEEDALGRVSNMDGGFSAARLSVLEYLYKIKRKANVIILREILPTYYAPVGNWHIRETVKNSLLKDPIIKTNDIREIILYIRNWVRANPNDVIEKSELLNLKKRKLTEFMNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB26</accession>
    <name>L0AB26_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232240.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70342">
        <property type="protein sequence ID" value="AFZ70342"/>
        <property type="gene ID" value="Calag_0584"/>
    </dbReference>
    <dbReference type="GeneID" id="14211844"/>
    <dbReference type="KEGG" id="clg:Calag_0584"/>
    <dbReference type="eggNOG" id="arCOG00144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_34_0_2"/>
    <dbReference type="OMA" id="IPGWVWR"/>
    <dbReference type="OrthoDB" id="42639at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="11"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="471" mass="50966" checksum="B8B18284B52FB038" modified="2013-03-06" version="1" precursor="true">MQKDPENPFLVLGVLTFTTALTSYVEAMVIPSLPHIEQALSATNEEAAWIVSAYLVVGAAIAPLFGKMGDTFGKKKLYLISLTLYSLAVLFAGFSPNVYFLIGSRAIQGFGFSIFPLSIAIITDIFPKERVALAQGILSAMVAIGMTIGIIAGAYIEEYLGWRAMFHIAFGIALISIIISYLSIGPHPPVKKEKIDYFSTTLLSIGTALILIYLTEAPYKGWISLYQLPIIVSGLALFIGFLVYITKSTNPLIRPDLLKIKNVMVANLAGLFSGVTMFTLYLAVIYYAEEPTPYGLGLSVINAAFSLLPATLAMIILAPLVGLAVSSIGPKPVLIYGSIVSLIGFSLFIFNRSGTLPLVLDSFVTGIGIISIMTPIVNMIAISMPEDSVTVGLGFNTMVRFLGSSIGPVMTANLMTTYVAYASYYLPKYGFSFFTEAGPVAFNYTFLIGIIFSFLTFVTALFMKNYTPKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB36</accession>
    <name>L0AB36_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70260">
        <property type="protein sequence ID" value="AFZ70260"/>
        <property type="gene ID" value="Calag_0494"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0494"/>
    <dbReference type="eggNOG" id="arCOG13726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2032751_0_0_2"/>
    <dbReference type="OMA" id="KVERCSE"/>
    <dbReference type="OrthoDB" id="139361at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="121" mass="13790" checksum="AB9066CA5F946DD2" modified="2013-03-06" version="1">MMKCSCDDKSKIDLVLCLAPPAGEYEVQIDLGSNKKLIINTDGIFVRSFSLDDFLPFMQTRQVKIKEKDIDLFKLSMKDLLCRTIDSLIDASNHGSIYAKEKVERCSELIDELSKYCKDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB42</accession>
    <name>L0AB42_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl14</name>
        <name evidence="5" type="ordered locus">Calag_1377</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232983.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1377"/>
    <dbReference type="EnsemblBacteria" id="AFZ71086">
        <property type="protein sequence ID" value="AFZ71086"/>
        <property type="gene ID" value="Calag_1377"/>
    </dbReference>
    <dbReference type="GeneID" id="14212637"/>
    <dbReference type="KEGG" id="clg:Calag_1377"/>
    <dbReference type="eggNOG" id="arCOG04095">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_3_0_2"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="OrthoDB" id="91632at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="140" mass="15148" checksum="889231963BFECEE3" modified="2013-03-06" version="1" precursor="true">MPKKKKYGAVLSRRGFSAGLQVGSVALVADNSGAKEALIVDVPLVKTRVRRLGRATVGDLVVVSIKKGTPQVRKQISYAVVIRQKRPYKRSDGTWISFNDNALVLVNPDGTPKGSEIRGAIPKEVAERWPTVAKLATSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB47</accession>
    <name>L0AB47_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233010.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1406"/>
    <dbReference type="EnsemblBacteria" id="AFZ71113">
        <property type="protein sequence ID" value="AFZ71113"/>
        <property type="gene ID" value="Calag_1406"/>
    </dbReference>
    <dbReference type="GeneID" id="14212666"/>
    <dbReference type="KEGG" id="clg:Calag_1406"/>
    <dbReference type="eggNOG" id="arCOG02159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082100_1_0_2"/>
    <dbReference type="OMA" id="KSYIAVN"/>
    <dbReference type="OrthoDB" id="110032at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011672">
        <property type="entry name" value="DUF1614"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07758">
        <property type="entry name" value="DUF1614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="233" mass="24571" checksum="02237FAD25BCDF0D" modified="2013-03-06" version="1" precursor="true">MFVSFYLLAGIIIALIAFRFPVYIAQSSYLSYAFPLGILSAVLIVLSPALSFVNLIVKRIRTGILENIVEVQYVDFFGIPIPVPKMTFKEATMSIAINIGGAVVPLAVSITLFALMAYSPYSHIFYTATIVSLIINTAVTYFLAKPIRGVGIAVPAFIPPIISAIPAILIAGISPAAASAAYISGSIGSLLGADILHLAKEPEKIFAPLVSIGGAGIFDGVFITGLIAFIIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABA6</accession>
    <name>L0ABA6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0577"/>
    <dbReference type="EnsemblBacteria" id="AFZ70335">
        <property type="protein sequence ID" value="AFZ70335"/>
        <property type="gene ID" value="Calag_0577"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0577"/>
    <dbReference type="eggNOG" id="arCOG02682">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_14_2"/>
    <dbReference type="OMA" id="IAQTCIG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="5">
        <location>
            <begin position="22"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="468" mass="50938" checksum="C1EFF7862B7B2C49" modified="2013-03-06" version="1">MSDHNPFEYIDNVKTNISHIKVWFTAGMGFFTDAYDLFVIGIILVILNRLASPAFHLTDLLSALLASSAIVTAIIGQLTFGRIADILGRKKVYGVEAIILVIGALMSAFSPNIYWLLASRFIMGFGIGGDYPISSTIMSEYSPRKDRGKLVSLVFAAQGIGIAVAVIVGLLSVSFFPHSISWRILAGIGAIPPALVIYYRRKIPETPRFSLLAKHDKEEAEKAIKFVGANTKVIQVKTKECSLREFLKSYSMLLIGTSIPWLLMDMALYGTGVFSSPITLAILGGSNSLKADVLRAGIPLLIGIPGYFLTAAFIDKIGRKTIQSMGFGVMALLYFIISESIITSGTKIDGFLIPTTLAYVLFGLTFLFINFGPNTTTFVLPSELYPVRYRTTGHGISAASGKLGAAITTFLFPFLLHSYGLKFILTMLGVVSAIGLIITLLTIPEPKMKSLEEISKEKIEVYEKPISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABA8</accession>
    <name>L0ABA8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ubiquinone-dependent succinate dehydrogenase or fumarate reductase, flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_0981</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232601.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0981"/>
    <dbReference type="EnsemblBacteria" id="AFZ70704">
        <property type="protein sequence ID" value="AFZ70704"/>
        <property type="gene ID" value="Calag_0981"/>
    </dbReference>
    <dbReference type="GeneID" id="14212241"/>
    <dbReference type="KEGG" id="clg:Calag_0981"/>
    <dbReference type="eggNOG" id="arCOG00571">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_2_2"/>
    <dbReference type="OMA" id="DPIPIQP"/>
    <dbReference type="OrthoDB" id="8547at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="9">
        <location>
            <begin position="9"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="10">
        <location>
            <begin position="457"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="583" mass="65403" checksum="AC21C461BDFB6318" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABB0</accession>
    <name>L0ABB0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233075.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1476"/>
    <dbReference type="EnsemblBacteria" id="AFZ71178">
        <property type="protein sequence ID" value="AFZ71178"/>
        <property type="gene ID" value="Calag_1476"/>
    </dbReference>
    <dbReference type="GeneID" id="14212736"/>
    <dbReference type="KEGG" id="clg:Calag_1476"/>
    <dbReference type="eggNOG" id="arCOG12514">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1478841_0_0_2"/>
    <dbReference type="OMA" id="VEYRIAM"/>
    <dbReference type="OrthoDB" id="140038at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="182" mass="21216" checksum="16CDF1883E80B271" modified="2013-03-06" version="1">MSNNIDPIDQAFRNIMEKIYWIEDIDEAEKELVKWLNKMDEDLKNLLLERRKKYCGNPMSIMEVIGLQNYLDQNEENRKDVEYRIAMAKELIDMGLLLQCLQVWNDMEPKVKAKVLAPLYKASYAYELALKNGLNEIDETHLNKSIEMAEQALEKADDLGLLSELRSYLESSLGRFVSSTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABB3</accession>
    <name>L0ABB3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative prefoldin, molecular chaperone implicated in de novo protein folding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1481"/>
    <dbReference type="EnsemblBacteria" id="AFZ71183">
        <property type="protein sequence ID" value="AFZ71183"/>
        <property type="gene ID" value="Calag_1481"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1481"/>
    <dbReference type="eggNOG" id="arCOG01341">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1801580_0_0_2"/>
    <dbReference type="OrthoDB" id="138774at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="145" mass="16371" checksum="392FDD925D315C01" modified="2013-03-06" version="1">MSKTQTIDVNTLIVQLEAIRSEISQLRSFISQLLLQRDGIVKAKSSIDAIGNSSEENIIFPLDPGYMAMTIAKPLDKNHFIIYLGADIYAKLETNEAMKILTEKESELNNAINDVSQRLSQLEKLQDQYESVLQQISEQAQQQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABC0</accession>
    <name>L0ABC0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Archaeal S-adenosylmethionine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233085.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1486"/>
    <dbReference type="EnsemblBacteria" id="AFZ71188">
        <property type="protein sequence ID" value="AFZ71188"/>
        <property type="gene ID" value="Calag_1486"/>
    </dbReference>
    <dbReference type="GeneID" id="14212746"/>
    <dbReference type="KEGG" id="clg:Calag_1486"/>
    <dbReference type="eggNOG" id="arCOG01678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057642_0_0_2"/>
    <dbReference type="OMA" id="IGHPDSI"/>
    <dbReference type="OrthoDB" id="21658at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.280">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027790">
        <property type="entry name" value="AdoMet_synthase_2_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042544">
        <property type="entry name" value="AdoMet_synthase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36697">
        <property type="entry name" value="PTHR36697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01941">
        <property type="entry name" value="AdoMet_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="406" mass="44670" checksum="53C9AEF587625289" modified="2013-03-06" version="1">MVKNIVVREVSASSVQDNQIELVERKGLGHPDYISDAASEEASRQLSLYYLQKYGVIMHHNLDKVLLVGGQATPKWGGGDVIQPIYIIVSGRATTEVRTSEGVEEIPVGRIVVKAVKEWISNNLRFLDPEQHVIVDYKIGKGSSDLRGIYDSKSQSHRSNDTSFGAGFAPMSTLERLVYETERTLNSKEFKNKVPASGEDVKVMGLRNGNNIDITIANAIVSRFVNNPSEYLQIKEEIKEKVLDLSSKIAPNYNVRVYVNNGDLPDEGVFYLTVTGTSAEHGDDGATGRGNRANGLITPMRPMSLEATAGKNPVTHIGKIYNIASKEIAEVIYSKVNGLKEVTVRLLGQIGRPINDPLIADVAVIPDSNVKLTSNMKQEINSIVDEYLENLPALTMRILKGETTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABD1</accession>
    <name>L0ABD1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232258.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0603"/>
    <dbReference type="EnsemblBacteria" id="AFZ70360">
        <property type="protein sequence ID" value="AFZ70360"/>
        <property type="gene ID" value="Calag_0603"/>
    </dbReference>
    <dbReference type="GeneID" id="14211863"/>
    <dbReference type="KEGG" id="clg:Calag_0603"/>
    <dbReference type="eggNOG" id="arCOG03772">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2079540_0_0_2"/>
    <dbReference type="OMA" id="MSGYALK"/>
    <dbReference type="OrthoDB" id="127333at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017140">
        <property type="entry name" value="UCP037214"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10015">
        <property type="entry name" value="DUF2258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="113" mass="12984" checksum="F101C89CD989E9EB" modified="2013-03-06" version="1">MEILLKTGPVRMSGYALKLRRAANAAFRKLYAEKKVDPKVVNQLLTDLNKNLYGVLVENYNIPKDIIVNIQIVFDLNDNSISIKDMDLTIYDKNEILSKELTKEFKKLLKINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABD6</accession>
    <name>L0ABD6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoate-protein ligase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232631.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1012"/>
    <dbReference type="EnsemblBacteria" id="AFZ70734">
        <property type="protein sequence ID" value="AFZ70734"/>
        <property type="gene ID" value="Calag_1012"/>
    </dbReference>
    <dbReference type="GeneID" id="14212272"/>
    <dbReference type="KEGG" id="clg:Calag_1012"/>
    <dbReference type="eggNOG" id="arCOG01939">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_0_0_2"/>
    <dbReference type="OMA" id="IILYLWQ"/>
    <dbReference type="OrthoDB" id="47035at2157"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="PTHR12561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="2">
        <location>
            <begin position="31"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="275" mass="31652" checksum="24DB320E8E23BFAF" modified="2013-03-06" version="1">MKLRVLMFETPHDGYYNIAFEEALARARGCNIIDDTLRFFRNKNAVIIGYFQKAEEEVNLDYLKKIDAQLIRRPTGGGAVYHDLGNLNYSIAVSYDKAKNMSPVDYIFSVLIKGPINALNSLGFDARLENINDIVVNNRKVSGTAASTSWNTLFFHGAMLLNTDMEKLSSVLKISQKKLIDKGVSSVKYRVTNLFDINNKIKIDDIINSFVNSYKQLLNYDDVYYSIPTKKEIEIASLIYEEKYTKYEWNYNRESHSVFQKLEEQIKELCQVISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABF0</accession>
    <name>L0ABF0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR00269 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232360.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0717"/>
    <dbReference type="EnsemblBacteria" id="AFZ70462">
        <property type="protein sequence ID" value="AFZ70462"/>
        <property type="gene ID" value="Calag_0717"/>
    </dbReference>
    <dbReference type="GeneID" id="14211977"/>
    <dbReference type="KEGG" id="clg:Calag_0717"/>
    <dbReference type="eggNOG" id="arCOG00042">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_1_1_2"/>
    <dbReference type="OMA" id="MNLDQKQ"/>
    <dbReference type="OrthoDB" id="57500at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00269">
        <property type="entry name" value="TIGR00269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="52"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="328" mass="37802" checksum="5AD8CC13BD92BA0F" modified="2013-03-06" version="1">MKLCSKCGIRPAEIYQAHSNKMLCKECFLEDVRNRAIEEIKRWNMIKSDDIVMMALSGGKDGYVLLDVLGNYFSKSNKLIGLNIIEGIHGYNKEEDAKYLVKTAKEYGVDVIVTSIKDYIGYSMDEIYEKTRNSKNSFTPCTYCGASRRRIMNYYAREMGATKLATAHNLDDEAQTAVINLMKGDINSLLKQHPNINITEDDMLVKRIKPLRKIYEWENASFTFIKNFHIQQTECPYIELAPTLRAKVRRELYKYERENPGVLIRFMETLDILLEYIHQDKVATKLNRCIKCGEPTTKGRNICKLCELLSSIGISNPSYLIKVPKKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABG7</accession>
    <name>L0ABG7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyprenyl p-hydroxybenzoate/phenylacrylic acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232661.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1042"/>
    <dbReference type="EnsemblBacteria" id="AFZ70764">
        <property type="protein sequence ID" value="AFZ70764"/>
        <property type="gene ID" value="Calag_1042"/>
    </dbReference>
    <dbReference type="GeneID" id="14212302"/>
    <dbReference type="KEGG" id="clg:Calag_1042"/>
    <dbReference type="eggNOG" id="arCOG01703">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074522_0_1_2"/>
    <dbReference type="OMA" id="GATHIQD"/>
    <dbReference type="OrthoDB" id="112962at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="1" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="190" mass="20990" checksum="3D0DE4FD19D55295" modified="2013-03-06" version="1">MECDDISVALTGASGIKYGLRLIEVLKQSNISIKGIIYSNSSIEVAKAEEGIEKNSFINILKQYANIYDENDFNSPLASSSNISKCMVICPASMKTIGLIANGIESTLISRAALAHLRLRRPLVVAFRETPLGIAELRNLLRIAHYGGIIMPLSPGFYSNKNNIEDLINFMVGKILDSLNIPNNLYKRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABH1</accession>
    <name>L0ABH1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rps12</name>
        <name evidence="5" type="ordered locus">Calag_1505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233103.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1505"/>
    <dbReference type="EnsemblBacteria" id="AFZ71206">
        <property type="protein sequence ID" value="AFZ71206"/>
        <property type="gene ID" value="Calag_1505"/>
    </dbReference>
    <dbReference type="GeneID" id="14212766"/>
    <dbReference type="KEGG" id="clg:Calag_1505"/>
    <dbReference type="eggNOG" id="arCOG04255">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115574_0_1_2"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="OrthoDB" id="85293at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_A">
        <property type="entry name" value="Ribosomal_S12_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022863">
        <property type="entry name" value="Ribosomal_S12_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_S23_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="147" mass="16495" checksum="2730A857888E2AC4" modified="2013-03-06" version="1">MGEGKSPNGLFAARQLRKKRMKFKWSQKEFKRRMLKLTEKYDPLEGSPMARAIVLEKVGVESRQPNSALRKCVRCQLIKNKKVVTAFVPKDGGVLYIDEHDEVIIEGIGGPKGGSLGDIPGVRYKVVMVNGVSLDALWKGKKQKVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABH5</accession>
    <name>L0ABH5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="1">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">carA</name>
        <name evidence="3" type="ordered locus">Calag_1511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233108.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1511"/>
    <dbReference type="EnsemblBacteria" id="AFZ71211">
        <property type="protein sequence ID" value="AFZ71211"/>
        <property type="gene ID" value="Calag_1511"/>
    </dbReference>
    <dbReference type="GeneID" id="14212772"/>
    <dbReference type="KEGG" id="clg:Calag_1511"/>
    <dbReference type="eggNOG" id="arCOG00064">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035901_1_1_2"/>
    <dbReference type="OMA" id="CFNTGMT"/>
    <dbReference type="OrthoDB" id="35557at2157"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="2">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="366" mass="41244" checksum="3224AFD61CDBBCDF" modified="2013-03-06" version="1">MICKRNRKGYLYLYDGTIIEGCGFGSQGYNFGEVVFTTSMNGYPEALTDPSYKGQILIITHPLVGNYGVPKMKVMDNNIIDNFESEKIQVEGLIVSEETEPRKWNSYMSLHEWLSDQGIPGLSDVDTRFLVKKIRDQGVVPGIISSGVELSELKKYNYDSIDFTDLTSPKEIILHKGKIDKNIVVIDCGVKHGILKGIYESFYYNIIRVPCKSNANEIMKFNPGGIVFSNGPGNPNLLNKLIDTYNAISEYKIPILGICLGHQIGTLALGGKVKKMKYGHRAINKPVIDLTTEKSYITTHNHGYAILSIKDLPNNVKPWFIDPDDKIIEGWISEEKKILSVQFHPEARPGPLDTTWIFEKFKKMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABI2</accession>
    <name>L0ABI2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232389.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0748"/>
    <dbReference type="EnsemblBacteria" id="AFZ70492">
        <property type="protein sequence ID" value="AFZ70492"/>
        <property type="gene ID" value="Calag_0748"/>
    </dbReference>
    <dbReference type="GeneID" id="14212008"/>
    <dbReference type="KEGG" id="clg:Calag_0748"/>
    <dbReference type="eggNOG" id="arCOG02872">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1149769_0_0_2"/>
    <dbReference type="OMA" id="NDINSTM"/>
    <dbReference type="OrthoDB" id="74659at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="241" mass="27483" checksum="BB8B4A0E1AAAC3D6" modified="2013-03-06" version="1">MIVVVIAIVIIGGFLAFNKSNKNVTPTSTSSITTSTTSSNLISVTPLLPYINSPLVPTYGNPSSKYYLFIIYDPECPYCAIEFNNTLPYLYYLAKNNYTMLVFVGMPIHQYSLEMIAMLDLIYQKYGFTQFYKILDKDYAIYYYNILLYENNKTSQLQVPTPYTIYMLLNQSNLSINYNDINSTMKDAYNIADLAYTQGIDATPMLIIYNTNTGNTINQFIGLYSPIEIESYLNKTLGVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABI8</accession>
    <name>L0ABI8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1067</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1067"/>
    <dbReference type="EnsemblBacteria" id="AFZ70789">
        <property type="protein sequence ID" value="AFZ70789"/>
        <property type="gene ID" value="Calag_1067"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1067"/>
    <dbReference type="eggNOG" id="arCOG00184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="PEIDRKW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="15"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="329" mass="37099" checksum="5010E68309B138CB" modified="2013-03-06" version="1">MSHVGYIDPNYIFYIKDLKVYFTKGGFLSKPLITKALDGINLKIRRKEVLALVGESGSGKTTLGRTLIGLQKPTSGQVIYNRDGNNPILIDPKAKHIKKVRRELQMIYQDPYSSIDPYMKVYNAMEQPLKYAGIKSKEEINKKIEQSLKMVGLPYDLVQNYVFQLSGGQRQRLSIARALSLDPKFLVADEPVTMLDASLKGEIVEVLSKINKETGITILFITHELPIAKIIANRIAVMYKGKIVEAGNAKTVLTDPLHPYTKALLEAYPRIDPTLKDTYKTVNVKEEGKIVSNGCPFYDRCPFATQKCLEQNPQLKEISSDHEVACWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABJ1</accession>
    <name>L0ABJ1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1527</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233123.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1527"/>
    <dbReference type="EnsemblBacteria" id="AFZ71226">
        <property type="protein sequence ID" value="AFZ71226"/>
        <property type="gene ID" value="Calag_1527"/>
    </dbReference>
    <dbReference type="GeneID" id="14212788"/>
    <dbReference type="KEGG" id="clg:Calag_1527"/>
    <dbReference type="eggNOG" id="arCOG00249">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010448_2_1_2"/>
    <dbReference type="OMA" id="GPYELMD"/>
    <dbReference type="OrthoDB" id="24701at2157"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="6">
        <location>
            <begin position="188"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="6">
        <location>
            <begin position="304"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="672" mass="74762" checksum="E426F2483861D94F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABJ3</accession>
    <name>L0ABJ3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233165.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1570"/>
    <dbReference type="EnsemblBacteria" id="AFZ71268">
        <property type="protein sequence ID" value="AFZ71268"/>
        <property type="gene ID" value="Calag_1570"/>
    </dbReference>
    <dbReference type="GeneID" id="14212832"/>
    <dbReference type="KEGG" id="clg:Calag_1570"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="HIMSIAE"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="239" mass="26438" checksum="2D9ABF9DEC6E6DA3" modified="2013-03-06" version="1">MDTNGFDAISLNNVVKLYGNFVALKGVTFRIPDGGKYALLGPNGAGKTTTLKLIAGLLKPDHGEVRVYGLDPISDLESKKIIGYLPEDATPYRNLSVRENLEYIAALRGIDDVKDKVEEMLDLLKLREYERAKVARLSRGNLQKLAIALSLIHRPKVLLLDEPLNYLDIPTQEEVISLLNKLGRTMLVSTHIMAVAGRLTDKIIMISRGIVIWSGSFEELKGMANEGEPIEKVVARLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABL5</accession>
    <name>L0ABL5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="5">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="5">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gatB</name>
        <name evidence="7" type="ordered locus">Calag_1558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233153.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1558"/>
    <dbReference type="EnsemblBacteria" id="AFZ71256">
        <property type="protein sequence ID" value="AFZ71256"/>
        <property type="gene ID" value="Calag_1558"/>
    </dbReference>
    <dbReference type="GeneID" id="14212820"/>
    <dbReference type="KEGG" id="clg:Calag_1558"/>
    <dbReference type="eggNOG" id="arCOG01718">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_0_1_2"/>
    <dbReference type="OMA" id="YLYFPDP"/>
    <dbReference type="OrthoDB" id="21200at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="6">
        <location>
            <begin position="331"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ71256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="477" mass="54769" checksum="CCC78D874E4B57AB" modified="2013-03-06" version="1">MIRLKYKIGLEIHTQLTESKTKLFCDCDSDYRKYEPNTNVCPICLGLPGALPVPRRNPLKLALAVADSFDCQIPEYMVFTRKHYFYPDLPKNYQITQYEKAGGIPVCLKGILKFFDPDKLIWKSVTLRRMNIEEDPGKTEYSEGNILLSEFAYLDYNRSGVPLLEIVTEPEIETPKDARKAVEYLLLTMEYIGAINPRLEGSFRVDANISVEGGERVEVKNIGSTLDLEKALKYEIFRQSKIVEEGGKIRRETRHWDSIRGVTKPLRSKETEEEYLYFPDPDIPAILTKPLLVEAKSKEFYTPERIMNKITMYGVTQKIAWSLITVKPSAELFLESVRIGADPRITARILAVDYKGLMKKSGKNIHDKNNWPKKEVLKEISSLIRNKVYTYDEIKYNILPKLLENNEIINISLPEKIEPSNLIITVLNEEKKAVEDFISGKKEALDYLVGQVLKKAKGKAIDPKLIRKIIEINIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABL9</accession>
    <name>L0ABL9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isocitrate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="3">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232419.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0780"/>
    <dbReference type="EnsemblBacteria" id="AFZ70522">
        <property type="protein sequence ID" value="AFZ70522"/>
        <property type="gene ID" value="Calag_0780"/>
    </dbReference>
    <dbReference type="GeneID" id="14212040"/>
    <dbReference type="KEGG" id="clg:Calag_0780"/>
    <dbReference type="eggNOG" id="arCOG01164">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_7_1_2"/>
    <dbReference type="OMA" id="CVRPCRY"/>
    <dbReference type="OrthoDB" id="33452at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004439">
        <property type="entry name" value="Isocitrate_DH_NADP_dimer_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504">
        <property type="entry name" value="PTHR43504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="6">
        <location>
            <begin position="34"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="421" mass="46744" checksum="BEACD80A409E3494" modified="2013-03-06" version="1">MGKIPCNVNELKPPSEGHFAKYENGKLIVPDDPIVAFFKGDGIGPEIVDSAIKIVDAAVSKAYGGKRKITWWQVAAGEEAEKECGTLLPDATLEAFKRARINLKGPLTTPVGSGFRSLNVAIRIALDLYANIRPVKWYGQPAPHCHPEKIDWVIFRENTEDVYMGIEFPWNSPEANKIRDFFKKELKIELRPDAGIGIKPISKFGTQRLMRRALEWALRNNIKRVTIQHKGNIQKYTEGAFREWAYEVAVNEFRDYVVTEDEVNTKFGGKTPQDKILVNDRIADNMLQQIITRPGEYNIIVAPNLNGDYISDEANALVGGIGMAAGMDMGDGIAVAEPVHGTAPKYAGKNVINPTAEILSAAVLIGDYMGWREVKVLIENAIKNAINNKQVTYDLAREMPGVQPISTSEYTDVLIGYIKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABN3</accession>
    <name>L0ABN3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232731.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1112"/>
    <dbReference type="EnsemblBacteria" id="AFZ70834">
        <property type="protein sequence ID" value="AFZ70834"/>
        <property type="gene ID" value="Calag_1112"/>
    </dbReference>
    <dbReference type="GeneID" id="14212372"/>
    <dbReference type="KEGG" id="clg:Calag_1112"/>
    <dbReference type="eggNOG" id="arCOG04141">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_198701_0_0_2"/>
    <dbReference type="OMA" id="WIEYDRQ"/>
    <dbReference type="OrthoDB" id="128518at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="71" mass="8462" checksum="6250CD1A7FDAA751" modified="2013-03-06" version="1">MERVEKVKNLIVEDPENIWMEYDKVGDTLYIGFSKDEEEETIMLENDMIINIKDNRLISLLIPNFKEKTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABN5</accession>
    <name>L0ABN5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232434.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0796"/>
    <dbReference type="EnsemblBacteria" id="AFZ70537">
        <property type="protein sequence ID" value="AFZ70537"/>
        <property type="gene ID" value="Calag_0796"/>
    </dbReference>
    <dbReference type="GeneID" id="14212056"/>
    <dbReference type="KEGG" id="clg:Calag_0796"/>
    <dbReference type="eggNOG" id="arCOG01430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_1_2"/>
    <dbReference type="OMA" id="GIRRWPE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="2">
        <location>
            <begin position="103"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="389" mass="43815" checksum="FBE5ED373917CF5D" modified="2013-03-06" version="1">MAKIKELDSLISDRVEFNIIIDKIKELLRSGTQKEAILIKGNKVIKNQEIYWALKYLGTKYAAVSENEENVNVSLDFLALYDEISDPGIRVYNNAIELIEKDKPTPLVKLNGIINDEKIKIWGKLEWYNPFSLSIKDRTAWYIIFNNLDKINNKEKIIEATSANTGISLSAISSILGKKTKILMPNSSPEYADKMLKIYGSEVVREGNSTNDLIEKVKKIAQEENAFVPDQFSNIFNVLVHLRYTAKELDYQAIYGKLRLKGIFASMGTGGHIAGILLYFHNKYNGIKVFGVQPMENGSIPGIKKQDFNKWWSISELPDKVFSVSFDEAVEMIVKTARNNGIIPGISGGAVLAGFKKAYEQGILEEGDYSCIIPDNGIKYLDDIYEELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABP5</accession>
    <name>L0ABP5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mn-dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232444.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0806"/>
    <dbReference type="EnsemblBacteria" id="AFZ70547">
        <property type="protein sequence ID" value="AFZ70547"/>
        <property type="gene ID" value="Calag_0806"/>
    </dbReference>
    <dbReference type="GeneID" id="14212066"/>
    <dbReference type="KEGG" id="clg:Calag_0806"/>
    <dbReference type="eggNOG" id="arCOG02100">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_4_1_2"/>
    <dbReference type="OMA" id="SWDAIDR"/>
    <dbReference type="OrthoDB" id="110491at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="134" mass="15156" checksum="DB964527D8606362" modified="2013-03-06" version="1">MSVHIKRRGISISLEEYLTTILKEGGNNNWIRFGNIAKSLGTTQASVTEAMQKLAKDGYIYYFPYKGVRLTNKGNELASSIVEKENEIKNLLIRIGVDEKESEDIACILEHKISDNAVKKLKEFVNKCVSDKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABT5</accession>
    <name>L0ABT5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Fructose-1,6-bisphosphate aldolase/phosphatase</fullName>
            <shortName evidence="15">FBP A/P</shortName>
            <shortName evidence="15">FBP aldolase/phosphatase</shortName>
            <ecNumber evidence="6 15">3.1.3.11</ecNumber>
            <ecNumber evidence="15">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">fbp</name>
        <name evidence="16" type="ordered locus">Calag_1168</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">Homooctamer; dimer of tetramers.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the FBP aldolase/phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="6 15"/>
    <dbReference type="EC" id="4.1.2.13" evidence="15"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232786.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1168"/>
    <dbReference type="EnsemblBacteria" id="AFZ70889">
        <property type="protein sequence ID" value="AFZ70889"/>
        <property type="gene ID" value="Calag_1168"/>
    </dbReference>
    <dbReference type="GeneID" id="14212428"/>
    <dbReference type="KEGG" id="clg:Calag_1168"/>
    <dbReference type="eggNOG" id="arCOG04180">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041630_0_0_2"/>
    <dbReference type="OMA" id="YMRRHGP"/>
    <dbReference type="OrthoDB" id="21175at2157"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02067">
        <property type="entry name" value="FBP_aldolase_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002803">
        <property type="entry name" value="FBPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036076">
        <property type="entry name" value="FBPase_V_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38341">
        <property type="entry name" value="PTHR38341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01950">
        <property type="entry name" value="FBPase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015647">
        <property type="entry name" value="FBPtase_archl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111249">
        <property type="entry name" value="SSF111249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 15" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="FBP binding" evidence="15">
        <location>
            <begin position="109"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="FBP binding; shared with dimeric partner" evidence="15">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for FBP phosphatase activity" evidence="15">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor; for FBP aldolase activity" evidence="15">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DHAP; for FBP aldolase activity" evidence="15">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ70889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="385" mass="42702" checksum="B733B1C8406F84A6" modified="2013-03-06" version="1">MSHERGEKITLSVIKADIGSLAGHHKVHPDTMLASTRVLAEAKKNGLLIDYYVTAVGDDLQLIMTHKKGVNNKEVHETAWNAFEEAAKVAKELGLYAAGQDLLSNSFSGNIRGMGPGVAEMEFNERPAEPVVVFMADKTEPGAFNLPLYKIFADPFNTAGLVIDPRMHNGFIFTVLDVYEGKALDLSTPNDLYDLLALIGTPSRYVIKYVHRKDGEIASTISSERLSLIAGKYIGKDDPVMIVRAQSGFPALGEILEPFSFPHLVEGWMRGSHAGPLMPVGIKDAKMTRFDGPPRVAALGFNIKNGNLVGPSDLFDDVAFDETRRQAQIIAEYMRRHGPFMPHRLGPEDMEYTTLPDVLKKLENKFRPFELGYKPIIKHELEEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABT6</accession>
    <name>L0ABT6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein implicated in secretion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232407.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0767"/>
    <dbReference type="EnsemblBacteria" id="AFZ70510">
        <property type="protein sequence ID" value="AFZ70510"/>
        <property type="gene ID" value="Calag_0767"/>
    </dbReference>
    <dbReference type="GeneID" id="14212027"/>
    <dbReference type="KEGG" id="clg:Calag_0767"/>
    <dbReference type="eggNOG" id="arCOG00452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095961_0_0_2"/>
    <dbReference type="OMA" id="VAPDIWI"/>
    <dbReference type="OrthoDB" id="76248at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="225" mass="25035" checksum="126F12467A910DBB" modified="2013-03-06" version="1">MSSLEDWNKRWYEQKKETIGQKVKEFVRPPPPLKGQIISASYKIATQINKLDYNLSKLEAYDKQLFEKTVNALVEGDKSKAGMYANEVAEVRKMAKVLMTVRFALERVKLRLDTTLIFGDVNADLAPAIIALKSVAGYLKGMMPDVFTELMGVDEELQMAMMQYSSGSVPMLENEFVTEEAQKILKDASLVAEQKMKQEFPEIPSVEGVPSSANNLNSATAGAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABW6</accession>
    <name>L0ABW6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative redox protein, regulator of disulfide bond formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232437.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0799"/>
    <dbReference type="EnsemblBacteria" id="AFZ70540">
        <property type="protein sequence ID" value="AFZ70540"/>
        <property type="gene ID" value="Calag_0799"/>
    </dbReference>
    <dbReference type="GeneID" id="14212059"/>
    <dbReference type="KEGG" id="clg:Calag_0799"/>
    <dbReference type="eggNOG" id="arCOG02074">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2565532_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="1">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="81" mass="9431" checksum="16941AF3242D15D2" modified="2013-03-06" version="1">MRSIDLRNLDCPEPMFLAYREFGKMGQGEEVEFIMDNEVCAYNSYKLIKNTGNALVTIMTDYNGLYKLHVIKIKDFRTSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABY1</accession>
    <name>L0ABY1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232519.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70622">
        <property type="protein sequence ID" value="AFZ70622"/>
        <property type="gene ID" value="Calag_0882"/>
    </dbReference>
    <dbReference type="GeneID" id="14212142"/>
    <dbReference type="KEGG" id="clg:Calag_0882"/>
    <dbReference type="eggNOG" id="arCOG00022">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140805_0_0_2"/>
    <dbReference type="OMA" id="WKDSPWH"/>
    <dbReference type="OrthoDB" id="114082at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="166" mass="19675" checksum="A13A46D9965F8DE9" modified="2013-03-06" version="1">MSSYKFEDRRRLVSYFKNEAKREINYSDDVRKTSNNSINPIVKLIMEAVSQDSIKHSKIYETMSLIIENPQLITEKESEMVLDDMKRHIENEKESIEELNNLLKDKAIQDDKPLKFLIEMLLRDEKLHHAMLSDLYNILIKNITLTERDIWDQIWKDSMYHGTPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC11</accession>
    <name>L0AC11_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232554.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0926"/>
    <dbReference type="EnsemblBacteria" id="AFZ70657">
        <property type="protein sequence ID" value="AFZ70657"/>
        <property type="gene ID" value="Calag_0926"/>
    </dbReference>
    <dbReference type="GeneID" id="14212186"/>
    <dbReference type="KEGG" id="clg:Calag_0926"/>
    <dbReference type="HOGENOM" id="CLU_483682_0_0_2"/>
    <dbReference type="OMA" id="AVYTHEL"/>
    <dbReference type="OrthoDB" id="141236at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="563" mass="64412" checksum="4FC3282426627E77" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC21</accession>
    <name>L0AC21_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232876.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1263"/>
    <dbReference type="EnsemblBacteria" id="AFZ70979">
        <property type="protein sequence ID" value="AFZ70979"/>
        <property type="gene ID" value="Calag_1263"/>
    </dbReference>
    <dbReference type="GeneID" id="14212523"/>
    <dbReference type="KEGG" id="clg:Calag_1263"/>
    <dbReference type="HOGENOM" id="CLU_730759_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="378" mass="43240" checksum="A2562517A681F26F" modified="2013-03-06" version="1">MILILFIFILRYLTSFNLTIYGISFILYLTVLPIIVSIFSAISTIYNKNYLPGIAISIIPFLFLSNTFMDYLLLIYIIFGIFVSFIVYFFIKSKKKIILNKPENPIPLAITAFSLSLILILNGTVDFNYRFLLSYFIFSLLSSFISSSEQKFLRSILLGISSSLGPIGFFITSSYIINKPVYINDCEGIELRGKLLLTSLGNKDLVCAEEDKIKLKLEKPFVLWIYNSRDLLNLKDYIEIGIGEKPKCDKENCVDLSNENLYNIINYLNNLNEDKDLLIKINKDLLINDEILNSIKNLSNKNNIIIELDEIVDKDIMPKFKAKSSGIVFCCINNPEKSFNISKIFLRDPYELSAIIKDKAIAYPSCNNEILILEPLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC25</accession>
    <name>L0AC25_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RecA-superfamily ATPase possibly involved in signal transduction</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232881.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1268"/>
    <dbReference type="EnsemblBacteria" id="AFZ70984">
        <property type="protein sequence ID" value="AFZ70984"/>
        <property type="gene ID" value="Calag_1268"/>
    </dbReference>
    <dbReference type="GeneID" id="14212528"/>
    <dbReference type="KEGG" id="clg:Calag_1268"/>
    <dbReference type="eggNOG" id="arCOG01174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046233_0_0_2"/>
    <dbReference type="OMA" id="WYIANTE"/>
    <dbReference type="OrthoDB" id="55361at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="440" mass="50180" checksum="64E13155C2F2C1F8" modified="2013-03-06" version="1">MKFSAKYTEAQIILIAGNPGTGKTTLGSKFLYEGLKNDENSIYLNFTETKKDFYRNMLNLGIDFEYYEKQGKFKYIEAITITDINALSDLLQELLNLIDKMNAKRLVIDSISAIMQLGEQNLGKIRELLHNFFYLGPKLKEVTTFLIAELPYGKKSVGYGVEEFIVDGVIILKIKIVKRKIIRLMEIRKMRGNEISIGEVPFVIEYPDVISFRVPPTLNIIPSGINPSKGFIEIKVGNNKLTFASGTQNIFIVNPSVDSLPFLSFIIPQLLVKGNRIVYRSYIHSESTIKDKMTKCLEYYPNNKELINNLLVRNLNPSSKSIIELELNAEKIDNIEKPNIVIVEGLSTYIDIVSDLDTYKEEHYNNLIRRAGNNITGFYFINEFEENMSKIPLISVYDNVFYLTIKDKNILLKSIRNHLKAVPLDPIEIDARSIESCIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC57</accession>
    <name>L0AC57_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hydro-lyase, Fe-S type, tartrate/fumarate subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232507.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0870"/>
    <dbReference type="EnsemblBacteria" id="AFZ70610">
        <property type="protein sequence ID" value="AFZ70610"/>
        <property type="gene ID" value="Calag_0870"/>
    </dbReference>
    <dbReference type="GeneID" id="14212130"/>
    <dbReference type="KEGG" id="clg:Calag_0870"/>
    <dbReference type="eggNOG" id="arCOG04407">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041245_0_0_2"/>
    <dbReference type="OMA" id="IETYPTH"/>
    <dbReference type="OrthoDB" id="59419at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="304" mass="33378" checksum="9179F5A7CA3B17A7" modified="2013-03-06" version="1">MGITEESLTGIFYELIKTASTSIPADVYEGLKTAYEKETNLAAKRQLEAILQDIEIACNKKVPICQDTGTPYFFIEMGENFPIRAGISKIAAQALRKVTKDGYLRPNAVDPFYKKNSGDNTGRYIPWMHFDIVEGDDLKVWFMTKGGGSEFPSTLIMSEPIEGFDKLKRGVIDTIVKFGPLPCPPLIVGISIAAGGDIAMTLAKKSLLRPIGERNPDPNLAKMEVDLLNEINKLELGPHGFGGQLTALDVKIDYAYRHPASFAIGIVTSCWATRRSSAIIHSDGSWEMTSKHISYNGTGCVIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC67</accession>
    <name>L0AC67_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232619.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0999"/>
    <dbReference type="EnsemblBacteria" id="AFZ70722">
        <property type="protein sequence ID" value="AFZ70722"/>
        <property type="gene ID" value="Calag_0999"/>
    </dbReference>
    <dbReference type="GeneID" id="14212259"/>
    <dbReference type="KEGG" id="clg:Calag_0999"/>
    <dbReference type="eggNOG" id="arCOG02959">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035477_0_0_2"/>
    <dbReference type="OMA" id="CHPKPGA"/>
    <dbReference type="OrthoDB" id="43374at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="238"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="570" mass="64101" checksum="A5B2FC4D3EBE7D18" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC71</accession>
    <name>L0AC71_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exonuclease of the beta-lactamase fold involved in RNA processing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232926.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1318"/>
    <dbReference type="EnsemblBacteria" id="AFZ71029">
        <property type="protein sequence ID" value="AFZ71029"/>
        <property type="gene ID" value="Calag_1318"/>
    </dbReference>
    <dbReference type="GeneID" id="14212578"/>
    <dbReference type="KEGG" id="clg:Calag_1318"/>
    <dbReference type="eggNOG" id="arCOG00545">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050517_0_0_2"/>
    <dbReference type="OMA" id="DHADFPS"/>
    <dbReference type="OrthoDB" id="105393at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="327" mass="37212" checksum="4EC42ED9C5AD42F1" modified="2013-03-06" version="1">MDDVVIEKSGAILLGKNFTIDGYSNRSIRVVTHAHEDHMKGLRRSIKDSIFIVATPITHEFLNILGYHIPNEKIIKLDYDKTIDIMDEKITLKKSRHIAGSAQVVVETNNAIVGYTGDFKLPGTEPLKDLDTLVVDATYGNLKYQRGWADWDALAALMNLINEYSNKGPIYIYGYNGKLQEIMVMLRERGVNNRFLADEKTLKMAQIASNYYGINLGNASIYNKELVDVDSIIFIHSTRYQNFNKLEGVHVLLTGWELRGVAVKVDENQFNVSFSDHATFKEIIEYIKESNPKRVIIDGSRSQDPWYIAKYLSKVLNLKVDVQPIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC95</accession>
    <name>L0AC95_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dimethyladenosine transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_1340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232946.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1340"/>
    <dbReference type="EnsemblBacteria" id="AFZ71049">
        <property type="protein sequence ID" value="AFZ71049"/>
        <property type="gene ID" value="Calag_1340"/>
    </dbReference>
    <dbReference type="GeneID" id="14212600"/>
    <dbReference type="KEGG" id="clg:Calag_1340"/>
    <dbReference type="eggNOG" id="arCOG04131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_0_2_2"/>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="6">
        <location>
            <begin position="35"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ71049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="263" mass="30415" checksum="2AC143D338022091" modified="2013-03-06" version="1">MSYEDFYLICKKINKKIEFKAIKKLSQHFLLDCDSIKVFYDNLVKYKNQDFLEIGTGIGTITFPISLIAKRVITVEIDRRFSYLKKELPNNVEIVFGDGLEFVKSTRIPILISNMPYSISSNLLINLSKNNNIRHSVLGMQKEVAERITAKPGEENYGRLSVIMQLLFNIKIVATIPSEKFFPKPKVDSSIVVIERMNLWKDEFNLLEKFTSCLFSQKNKKAQKIINNCLGNIGQIRSNCLQDNNKRVKDLTPKEILCLLFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACA2</accession>
    <name>L0ACA2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0934"/>
    <dbReference type="EnsemblBacteria" id="AFZ70665">
        <property type="protein sequence ID" value="AFZ70665"/>
        <property type="gene ID" value="Calag_0934"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0934"/>
    <dbReference type="eggNOG" id="arCOG02884">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1673896_0_0_2"/>
    <dbReference type="OMA" id="YIENHEN"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="157" mass="18058" checksum="49375DD515AF4D53" modified="2013-03-06" version="1">MIDDKIKYILSGFFIIISITFLGNFLMTYWKPGPYSLLATLNTNKELGGYPNNVPVNSTFTLYAYIENHENKIGFYEVNVYILNASIDVNSTFYLHKKPYLKIYSIINNNGNSTIPFNVTFEKSGQYKIALLLFLYNGTDFQYTNLYNQLYVNATVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACJ1</accession>
    <name>L0ACJ1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptidyl aminopeptidase/acylaminoacyl peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232672.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1053"/>
    <dbReference type="EnsemblBacteria" id="AFZ70775">
        <property type="protein sequence ID" value="AFZ70775"/>
        <property type="gene ID" value="Calag_1053"/>
    </dbReference>
    <dbReference type="GeneID" id="14212313"/>
    <dbReference type="KEGG" id="clg:Calag_1053"/>
    <dbReference type="eggNOG" id="arCOG01646">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03383">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_2_2_2"/>
    <dbReference type="OMA" id="YIHGGPK"/>
    <dbReference type="OrthoDB" id="3754at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="428"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="639" mass="73458" checksum="8A9C7FB739D494EF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACJ5</accession>
    <name>L0ACJ5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232764.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1145"/>
    <dbReference type="EnsemblBacteria" id="AFZ70867">
        <property type="protein sequence ID" value="AFZ70867"/>
        <property type="gene ID" value="Calag_1145"/>
    </dbReference>
    <dbReference type="GeneID" id="14212405"/>
    <dbReference type="KEGG" id="clg:Calag_1145"/>
    <dbReference type="eggNOG" id="arCOG04327">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171557_0_0_2"/>
    <dbReference type="OMA" id="ARERWVT"/>
    <dbReference type="OrthoDB" id="126910at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_S25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="90" mass="10213" checksum="C3FEAFA7EC48B21C" modified="2013-03-06" version="1">MSKEVSKKPGKQPKAKEEKKQTSAFDASSELISRVKKDLAKLNYVTPYKVANSYNVALSTARRILKELEKEGVLVLYSPSRRNPVYILKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACL2</accession>
    <name>L0ACL2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gpmA</name>
        <name evidence="6" type="ordered locus">Calag_1455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1455"/>
    <dbReference type="EnsemblBacteria" id="AFZ71159">
        <property type="protein sequence ID" value="AFZ71159"/>
        <property type="gene ID" value="Calag_1455"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1455"/>
    <dbReference type="eggNOG" id="arCOG01993">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_1_4_2"/>
    <dbReference type="OMA" id="RMLPYWY"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="211" mass="24229" checksum="53AD252D26E152C2" modified="2013-03-06" version="1">MGVNAMPILSLLRHGESLWNEENRFTGWVDVPLTNKGREEAIRAGLLLKKYKFDVAYTSKLQRAIETLDLVMLTLGYSIPVIKDEHLNERHYGDLQGLNKEETARIYGEDQVKLWRRSYKVRPPNGESLEDTQKRTVPFFKNTIMLDLKNGKNVLVVAHGNSLRSIVMFLENISEEDIPHLEIPTGLPIIYDVAWDNKNSKLIINSKTILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACP5</accession>
    <name>L0ACP5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit Rpo5</fullName>
            <ecNumber evidence="6">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpo5</name>
        <name evidence="6" type="synonym">rpoH</name>
        <name evidence="8" type="ordered locus">Calag_1498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233096.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1498"/>
    <dbReference type="EnsemblBacteria" id="AFZ71199">
        <property type="protein sequence ID" value="AFZ71199"/>
        <property type="gene ID" value="Calag_1498"/>
    </dbReference>
    <dbReference type="GeneID" id="14212758"/>
    <dbReference type="KEGG" id="clg:Calag_1498"/>
    <dbReference type="eggNOG" id="arCOG04258">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058320_4_0_2"/>
    <dbReference type="OMA" id="PKIYHDD"/>
    <dbReference type="OrthoDB" id="123463at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="PTHR10535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="SSF55287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb5_C" evidence="7">
        <location>
            <begin position="10"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="84" mass="9518" checksum="B3605476BADFE183" modified="2013-03-06" version="1">MPSKLREEDKILGHYLVPKHRILPLEESVEVLKSLGIKPWQLPRISINDPVVKILGGKPGDIIEIERDSPTAGKYKAYRVVVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACQ1</accession>
    <name>L0ACQ1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1113"/>
    <dbReference type="EnsemblBacteria" id="AFZ70835">
        <property type="protein sequence ID" value="AFZ70835"/>
        <property type="gene ID" value="Calag_1113"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1113"/>
    <dbReference type="eggNOG" id="arCOG13707">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1763781_0_0_2"/>
    <dbReference type="OMA" id="CEDSCET"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="147" mass="17252" checksum="AFC22AD9164141B9" modified="2013-03-06" version="1">MKFLRKKCEDSCETYSIILEQNSERIAQLMQEQISLINNGNVAHNSYLSDKKEETLNELNEIINRLREIRNVISSEVDKYSDFIECCDNKKSDDVELLIAYYLEAGSRKEEEFLKSISNEIDTKEDLVNLRSLIMRIKGNENFKFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACR2</accession>
    <name>L0ACR2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ordered locus">Calag_1123</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232742.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1123"/>
    <dbReference type="EnsemblBacteria" id="AFZ70845">
        <property type="protein sequence ID" value="AFZ70845"/>
        <property type="gene ID" value="Calag_1123"/>
    </dbReference>
    <dbReference type="GeneID" id="14212383"/>
    <dbReference type="KEGG" id="clg:Calag_1123"/>
    <dbReference type="eggNOG" id="arCOG04338">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057426_2_0_2"/>
    <dbReference type="OMA" id="YIAIHIA"/>
    <dbReference type="OrthoDB" id="108934at2157"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AFZ70845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="243" mass="27140" checksum="16643F0596A89342" modified="2013-03-06" version="1" precursor="true">MKRAIKGFLSLLSFLTTIPTNQNNIKEASEYFYLSPLIGLIEGIIIGLIFFLLRFNFIINGSILLASHLLLTGGLNLDGFSDYSDVIGSRKIGEEAEKILKDPRKGSFAIIFTSLIIIIRFASFSNIKNIFSIVLSYVTGIESGYLISYFSNAPKYQGLGSMFIESSKNKKKLLYNLIIYLIIIIILLFVSKTKYYLISIFSLLLVPIIVFDSNKRLGYANGDVIGFTIEIIETASLLISVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACS5</accession>
    <name>L0ACS5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232844.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1230"/>
    <dbReference type="EnsemblBacteria" id="AFZ70947">
        <property type="protein sequence ID" value="AFZ70947"/>
        <property type="gene ID" value="Calag_1230"/>
    </dbReference>
    <dbReference type="GeneID" id="14212490"/>
    <dbReference type="KEGG" id="clg:Calag_1230"/>
    <dbReference type="eggNOG" id="arCOG01057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_3_2"/>
    <dbReference type="OMA" id="CAWTRRY"/>
    <dbReference type="OrthoDB" id="102459at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="112" mass="12766" checksum="C7478B21363A920D" modified="2013-03-06" version="1">MSQDKCELTQNLWEKLAKKWTLAVVYNLGKSNGSGFNELKNNIGNISPSSLVERLTELESMGIIKREVIPNKPPRVLYKLTKKGEELYNILDQLVSWYLKNSEVIIGNKEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACV7</accession>
    <name>L0ACV7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfite oxidase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232874.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1261"/>
    <dbReference type="EnsemblBacteria" id="AFZ70977">
        <property type="protein sequence ID" value="AFZ70977"/>
        <property type="gene ID" value="Calag_1261"/>
    </dbReference>
    <dbReference type="GeneID" id="14212521"/>
    <dbReference type="KEGG" id="clg:Calag_1261"/>
    <dbReference type="eggNOG" id="arCOG00264">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_876029_0_0_2"/>
    <dbReference type="OMA" id="KSESKWI"/>
    <dbReference type="OrthoDB" id="98978at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="1">
        <location>
            <begin position="161"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="333" mass="37950" checksum="D41B456DAFD8A4F6" modified="2013-03-06" version="1">MEIQGCKAYYNKELEALDIPIVFECGGSIKIKGFNDIKNVALNTIKTLNELFDYSFELGDYIERELIGRSFNLHKFKINALDGILRIVEKNGYFLNSSGVIFSSVLNKFNENIAGNLIKGKTLEFGEKLEPIFLDKSCSSEIPVGQKEIPKFVIYIAENYIPSIDINNYKLSIKGNVPKEIELSYNELEEISKDIGEKDFHCVTGWSVKGRKWKGISVWELLKLSGIKSESKWILAKSLTGYSSTIPMDKELLENTFVVIEMDNKKLSPESGFPARIYSPELFGWKGAKYLSSLYISDKYIDGYWEALSYHERGKANSNERFKIRNPDVVDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD38</accession>
    <name>L0AD38_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small nuclear ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232862.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1248"/>
    <dbReference type="EnsemblBacteria" id="AFZ70965">
        <property type="protein sequence ID" value="AFZ70965"/>
        <property type="gene ID" value="Calag_1248"/>
    </dbReference>
    <dbReference type="GeneID" id="14212508"/>
    <dbReference type="KEGG" id="clg:Calag_1248"/>
    <dbReference type="eggNOG" id="arCOG00999">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145829_0_0_2"/>
    <dbReference type="OMA" id="FPGMVKY"/>
    <dbReference type="OrthoDB" id="100815at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028277">
        <property type="entry name" value="Lsm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037156">
        <property type="entry name" value="Lsm_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14894">
        <property type="entry name" value="Lsm_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Lsm_C" evidence="2">
        <location>
            <begin position="83"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="148" mass="16688" checksum="0B5EFA27FB2FC042" modified="2013-03-06" version="1">MSASPEPARRFVSRLNSLLDRNVTIKLINGRTYTGKLTGYDPTTYSIMLESAKDNEGNIWPLSIIYGNNISEILMGESEIFNAKEFSEFLSRFGNIEKHLIKVYDDINVVEVGKSIKVSKDGVEGSGPLAQKIYSIYREYLRTKGINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADA9</accession>
    <name>L0ADA9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, type IV secretory pathway VirB11 component like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1388"/>
    <dbReference type="EnsemblBacteria" id="AFZ71097">
        <property type="protein sequence ID" value="AFZ71097"/>
        <property type="gene ID" value="Calag_1388"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1388"/>
    <dbReference type="eggNOG" id="arCOG01817">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005379_2_2_2"/>
    <dbReference type="OMA" id="MHAETIE"/>
    <dbReference type="OrthoDB" id="9947at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="1">
        <location>
            <begin position="147"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="475" mass="54010" checksum="ED95AE825F0AA7AF" modified="2013-03-06" version="1">MILKMPILEKVIKIIKNNSNEKENVTQEFFYEKEKNFRKIPPKWSLVAQYKIGPNNYYLYRGEDNLVHLYVSEPEINVTTELLAGLKKDIKEEEKYIIEKYKSGYGKIYPLIIDPNIDEISYSGFTGNISAIHKLVPLRWIIVDIRISKEEADSLAVELARKANKVISISTPYVEGITDDGNRISVSFLNEISHFGSNFVLRKYPEKPLTMSDLLISKVLTPPIAAYLWLLAEAQGFLIISGSMGSGKTTLLQSIASLLPPYSKVITIEDTPELKLINPNWDSFITRPKLPGTEMQEIDLEDLLKYALRRRADYVIVGEVRGKEAKYLAQAATSGYGAMTTIHSDSPEGVITRLSLDPIKLPSLFIKSITAIIQIRNLPSLGGKTIRRVYEISEVDDKNLINIYKLGNQQNDVNNIINNSKKLEIAINRLGFNYSEIYDEFTSRIKFLENNMGKTPEELYVSLSRFYVEKYGDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADC5</accession>
    <name>L0ADC5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1405"/>
    <dbReference type="EnsemblBacteria" id="AFZ71112">
        <property type="protein sequence ID" value="AFZ71112"/>
        <property type="gene ID" value="Calag_1405"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1405"/>
    <dbReference type="eggNOG" id="arCOG00033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022610_0_1_2"/>
    <dbReference type="OMA" id="ANDANPW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040601">
        <property type="entry name" value="Trm5_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18093">
        <property type="entry name" value="Trm5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="3">
        <location>
            <begin position="111"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ71112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="359" mass="41481" checksum="41D6A8E1891939E3" modified="2013-03-06" version="1">MKITYCFNFCFSYKNWVSKERGYNSLNSPCIKISKQYGEDVIKILKEAKILNNELKPKIQDNKLLIPVIDVEKSLAIIKGVADIDFCNDTFEEYKFKTKKLNRIIKGISSYTIIGDIAIINYKKDIELLERAAKEIVKINPKIKSVYAKIDTEGEYRVPKLILLYGEKRTITRHKENGLIFYVDIEKTYFNPKLGGEHNRIASLVKENETVLDMFSGVGGFTLNIIKRNKVNVLGVDLNPYAISLASLNYMINKKIFKGDAVFMRANALFLQDIIKNKFDRIIMNHPTGSINFLNVACNLANEKANIHLYTILENKNLKLNDIKDKLKESCDKKYEINQPRRVLEYSPKYSIFEININF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADC6</accession>
    <name>L0ADC6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Twin arginine-targeting protein translocase, TatA/E family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232952.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1346"/>
    <dbReference type="EnsemblBacteria" id="AFZ71055">
        <property type="protein sequence ID" value="AFZ71055"/>
        <property type="gene ID" value="Calag_1346"/>
    </dbReference>
    <dbReference type="GeneID" id="14212606"/>
    <dbReference type="KEGG" id="clg:Calag_1346"/>
    <dbReference type="eggNOG" id="arCOG02694">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_6_2_2"/>
    <dbReference type="OMA" id="IAGQEWI"/>
    <dbReference type="OrthoDB" id="130608at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="66" mass="7297" checksum="F5AF39289F07DD38" modified="2013-03-06" version="1">MLDSLIDWLIVIVVIAILFGGATKIPEIARALGRAVGEFKKGQMEVEKELKESINNDKAKKDEGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADD1</accession>
    <name>L0ADD1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arsenite oxidase, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_1351</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232957.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1351"/>
    <dbReference type="EnsemblBacteria" id="AFZ71060">
        <property type="protein sequence ID" value="AFZ71060"/>
        <property type="gene ID" value="Calag_1351"/>
    </dbReference>
    <dbReference type="GeneID" id="14212611"/>
    <dbReference type="KEGG" id="clg:Calag_1351"/>
    <dbReference type="eggNOG" id="arCOG01720">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_1_3_2"/>
    <dbReference type="OMA" id="PLTDEPC"/>
    <dbReference type="OrthoDB" id="67221at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014067">
        <property type="entry name" value="Arsenite_oxidase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02694">
        <property type="entry name" value="arsenite_ox_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="68"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ71060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="205" mass="21762" checksum="5DC1B2D058C705B1" modified="2013-03-06" version="1">MENKDEKVNDKIDIGKRNFLKFLLAAGTVVAVGGALEPVFKYALSYEQTGLTSFPKVKVANINDLQVNQPITFNYPLENEPNYLVKLGQPAEGGIGPNNDIVAFSAICEHMGCIYHFETSLTPYGGPNVPGGHCPCHGSLYDYLEKAKVVGGPAPCPVPMVQLVLDSSTGDIYAVGMNPPTIYDHGTPCGTDVTADLTGGTPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADH7</accession>
    <name>L0ADH7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative butyrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233074.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1475"/>
    <dbReference type="EnsemblBacteria" id="AFZ71177">
        <property type="protein sequence ID" value="AFZ71177"/>
        <property type="gene ID" value="Calag_1475"/>
    </dbReference>
    <dbReference type="GeneID" id="14212735"/>
    <dbReference type="KEGG" id="clg:Calag_1475"/>
    <dbReference type="eggNOG" id="arCOG04329">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075234_0_0_2"/>
    <dbReference type="OMA" id="NIYFTPG"/>
    <dbReference type="OrthoDB" id="76280at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009927">
        <property type="entry name" value="DUF1464"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07318">
        <property type="entry name" value="DUF1464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009433">
        <property type="entry name" value="DUF1464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="374" mass="41715" checksum="82A4BB9C5289A015" modified="2013-03-06" version="1">MVRAIGIDSGTMSMDLLGFDDKDNNVFLDEAIPREIITSNPEKPIEIIKSLGKVDAIVVSSGYGIPFKRAQESSDKEIELATFINKDDLERKLKIVGLRNLMKLFKSSDLPAYFVPGIIQLNTIPEYRKINRIDLGTSDKLFSAAEALRNEKVYYKKDPKESDIIVIEIGYAYTAALSILHGEIIDGIGGTSGFPGYKGMGAIDGELAYAMASSEPYFSKLRLFQGGIADYLGFDNIDKLNEISKNDKSNKALKMFIESILKDLSIMIVSNTKPERIYLSGRFTRYDNLYAYIKESIEEFLEKISIKAKVVKLMGLGKKAKEAASGAAVLANGISNGTYKDIFEALKLKESKGYIFDFILPIDLRKEIENYFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADI5</accession>
    <name>L0ADI5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1485"/>
    <dbReference type="EnsemblBacteria" id="AFZ71187">
        <property type="protein sequence ID" value="AFZ71187"/>
        <property type="gene ID" value="Calag_1485"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1485"/>
    <dbReference type="eggNOG" id="arCOG00602">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076812_4_0_2"/>
    <dbReference type="OMA" id="RQLMRDY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="83"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="150"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="222"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="280" mass="31994" checksum="603B5FC74FF77267" modified="2013-03-06" version="1">MRNLQKSFLYEIGNTKVISIIDRTRPIAYNDDSIATLRKIIRNTGARALPILDRNSGNFLGVINRSDVLIVSSTKTNATSSSILKEHLLEINSNYTIFETLNLMFKYDLWEIPILEGKKYIGLVSISDIVKLLFNKAKDYLKNINAENYMTKEPITVNLEDPISKIWKKMMEYKYAGFPVVNDKEKLTGIITQLDLIKKGYTRIHLESESGVKNQTKVKDAMTYTVIYGYPWSTLYEISIPIVKKDYGRIPIVSSENDKKVVGIIDREDIAKVIIKGDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADL8</accession>
    <name>L0ADL8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233124.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1528"/>
    <dbReference type="EnsemblBacteria" id="AFZ71227">
        <property type="protein sequence ID" value="AFZ71227"/>
        <property type="gene ID" value="Calag_1528"/>
    </dbReference>
    <dbReference type="GeneID" id="14212789"/>
    <dbReference type="KEGG" id="clg:Calag_1528"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_2"/>
    <dbReference type="OMA" id="GALPHMY"/>
    <dbReference type="OrthoDB" id="62124at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="261" mass="28490" checksum="590799C6A3ADB2B3" modified="2013-03-06" version="1">MRYALVTGGDRGIGKAIAIKLSSQNIFTIISYRKREEEAISTLNYIKSKNGKGDMIKADISNKEDVEKMANYIKEKYGGIDILINNAGVGFTSKFTDLSYDSFVKQIQTNLIGSFYVTRLLIDNMINKKWGRIIFMSSIAGIFGAEYLTAYSSAKAGLIGLAKSLAIELAKHNITVNVVAPGFVETKLGKSYFEWLDSIGYKESEKMYLSSIPSNRLATEEEVASLVSFLVSEDASGITGQVIGVDAGASLTPGSVFKKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADM4</accession>
    <name>L0ADM4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-quinone oxidoreductase, B subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233032.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1428"/>
    <dbReference type="EnsemblBacteria" id="AFZ71135">
        <property type="protein sequence ID" value="AFZ71135"/>
        <property type="gene ID" value="Calag_1428"/>
    </dbReference>
    <dbReference type="GeneID" id="14212688"/>
    <dbReference type="KEGG" id="clg:Calag_1428"/>
    <dbReference type="eggNOG" id="arCOG01554">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_2"/>
    <dbReference type="OMA" id="GPYWEHG"/>
    <dbReference type="OrthoDB" id="100307at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="74"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="211" mass="23773" checksum="A33AEB37E919284E" modified="2013-03-06" version="1">MSKNEKGNGEEKGKVYLADLDTVAEEAKQMLLKGTVGKMVDWANAFSLWPVHLMTSCCGCEIGAAWGPRFDNERYGSLPWVSPRQTNLIIVEGTVTKKMACSVRITWDQMPYPKFAVAMGACSLDGGIFYNSYNIVRPWQVIPIDVYIPGCPPRPEAVSRAIVELQKLLRNKSIASKWITESKREDMKNIIPKEDLCGWRGEKVDLHTRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADP0</accession>
    <name>L0ADP0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1554"/>
    <dbReference type="EnsemblBacteria" id="AFZ71252">
        <property type="protein sequence ID" value="AFZ71252"/>
        <property type="gene ID" value="Calag_1554"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1554"/>
    <dbReference type="eggNOG" id="arCOG01359">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533842_0_0_2"/>
    <dbReference type="OMA" id="HTPGKYL"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="187"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="522" mass="59198" checksum="B44AA6B1BCFFD69D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADT4</accession>
    <name>L0ADT4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ71205">
        <property type="protein sequence ID" value="AFZ71205"/>
        <property type="gene ID" value="Calag_1504"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1504"/>
    <dbReference type="HOGENOM" id="CLU_3387394_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="32" mass="3681" checksum="B119A137280C8D86" modified="2013-03-06" version="1" precursor="true">MNIFKDGLIKMKQSLYSRIIHITFARAVTNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7K9</accession>
    <name>L0A7K9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DHD superfamily phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231704.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0010"/>
    <dbReference type="EnsemblBacteria" id="AFZ69806">
        <property type="protein sequence ID" value="AFZ69806"/>
        <property type="gene ID" value="Calag_0010"/>
    </dbReference>
    <dbReference type="GeneID" id="14211271"/>
    <dbReference type="KEGG" id="clg:Calag_0010"/>
    <dbReference type="eggNOG" id="arCOG00423">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076809_0_0_2"/>
    <dbReference type="OMA" id="THTDMDG"/>
    <dbReference type="OrthoDB" id="36193at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="1">
        <location>
            <begin position="218"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="343" mass="38398" checksum="4ECE8F08C2558AAC" modified="2013-03-06" version="1">MGSNNVNKIYIITHNDLDGMGGAASILRILGKKLNDSVIIFAEPYNVENAIEGIIDSVNKGDYLFLVDIGSNKNNISYVYNYFKEISKKGVEIYWFDHHVWEDKDIQLIKSIGVNVIVDTSTCGTGVAIKYASKIFEKNIDDFLEKLEKAICASDIWKWDDELGAKLFRATYANGGLNGLEWKFKVIDKFINGIIWDEELEEHLRYYIRKELEGYDRILSTLKTYGNSCKVSGVFKDTDIPSDSIVGAMILSRSNSDIAVIIKKKGFNLVSLSLRSRDKANVQLIAKSLGGGGHPKASGASMNIPLYVSLISLFDKSFLIKYVIKNIYSLALNNNSCLLNKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7L5</accession>
    <name>L0A7L5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Imidazolonepropionase</fullName>
            <ecNumber evidence="2">3.5.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231761.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0072"/>
    <dbReference type="EnsemblBacteria" id="AFZ69863">
        <property type="protein sequence ID" value="AFZ69863"/>
        <property type="gene ID" value="Calag_0072"/>
    </dbReference>
    <dbReference type="GeneID" id="14211332"/>
    <dbReference type="KEGG" id="clg:Calag_0072"/>
    <dbReference type="eggNOG" id="arCOG00696">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041647_0_1_2"/>
    <dbReference type="OMA" id="CAPHARW"/>
    <dbReference type="OrthoDB" id="44408at2157"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="266"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="407" mass="46213" checksum="A0A1903EC188E0F9" modified="2013-03-06" version="1">MVKADLIIYNIGELVYFTEPVRKINDGNTKILHDYGIAIKDGKILEIGNSEYIKTKYESQNIINAEGNLVTSGLIDMHTHALFAGSREDELYKKLLGISYAQILKEGGGIYKTVKSTRDASFESLKNRLDKVLMNSLSNGTTTIEIKSGYGLDLENEIKMLKVINNLKDKYDIVPTLLAHVIPKEFNEEEYIDYFINKIIPEVSRLNLAKYVDVFCDENVFNMQQTRKIFNQSIKYGFRLRLHADQLKYIGCSKLINEFLIDSIDHLENCPEENLEEISKTNTVIGLLPASTISMLSDNKPRIKPIKGKALFALGSDFSANSPMISMQTAIDLAIYYLNFTPIEALAFSTINSAYSLRLENKGTIREGYDANLLIWDLENINQLGYYWGYNRIKKIVYRGNVINGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7T3</accession>
    <name>L0A7T3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231831.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0147"/>
    <dbReference type="EnsemblBacteria" id="AFZ69933">
        <property type="protein sequence ID" value="AFZ69933"/>
        <property type="gene ID" value="Calag_0147"/>
    </dbReference>
    <dbReference type="GeneID" id="14211407"/>
    <dbReference type="KEGG" id="clg:Calag_0147"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_5_2"/>
    <dbReference type="OMA" id="FATISYM"/>
    <dbReference type="OrthoDB" id="82255at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="370" mass="41394" checksum="19DD5C6377B48546" modified="2013-03-06" version="1" precursor="true">MKKSLIIFITSSSFFLSYFSRIAWSIVSSYSSLKPNTIQDSLIYSLFFIGYVIVQIPAGLVSDQIKPSNIALISLIGLSITSFISGFSNSIFIEYIASFAMGLSAGWIYPVTIKILTLKFNDKERAVAIGYYSLAWPLSIVLAGLILPFISIRFGWRYSYYMISLLSFIFSLSYLFLDVKQGGNKAKFEIIKDKNVLIISLSGFLFFLAYWNITLYAYKYFLYIGINSYLSGLLYSLLALAGIPATIIAGYIIRNIGVKSSLVIFELLYGVLTLMLSIFFRPDLLALISSLMGFVRFIITPANSTAVSFIGKEKAGSVTGFANFFWQSSGIVSPLVSSTIILRINYYSLWLISGLMIIVSSLIYYMFLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7U8</accession>
    <name>L0A7U8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TIM-barrel fold metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0162"/>
    <dbReference type="EnsemblBacteria" id="AFZ69948">
        <property type="protein sequence ID" value="AFZ69948"/>
        <property type="gene ID" value="Calag_0162"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0162"/>
    <dbReference type="eggNOG" id="arCOG00691">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_3_1_2"/>
    <dbReference type="OMA" id="VAWVGSE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="2">
        <location>
            <begin position="53"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="513" mass="58765" checksum="1A73926632F5BDC2" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7Z0</accession>
    <name>L0A7Z0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP:cob(I)alamin adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0206"/>
    <dbReference type="EnsemblBacteria" id="AFZ69988">
        <property type="protein sequence ID" value="AFZ69988"/>
        <property type="gene ID" value="Calag_0206"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0206"/>
    <dbReference type="eggNOG" id="arCOG00489">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083486_0_1_2"/>
    <dbReference type="OMA" id="HQACTVV"/>
    <dbReference type="OrthoDB" id="98914at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="4">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ69988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="176" mass="19906" checksum="A228C52B25E1E781" modified="2013-03-06" version="1">MSHVFTRTGDDGNTYCNLLKTRVPKDHPIIELIGTLDEANSFIGLARSFIPSYMSDVGNDLKDLQYLTFRIGFHVSGINSLKEEDVKKLEELADKYYGKAPLKNFILPAGPQPSAALHVARTIVRRAERDLIKASRVYKFDDIVFKTINRLSSVLFAMAVYISKEMGYPEEPVSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A822</accession>
    <name>L0A822_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231916.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0236"/>
    <dbReference type="EnsemblBacteria" id="AFZ70018">
        <property type="protein sequence ID" value="AFZ70018"/>
        <property type="gene ID" value="Calag_0236"/>
    </dbReference>
    <dbReference type="GeneID" id="14211496"/>
    <dbReference type="KEGG" id="clg:Calag_0236"/>
    <dbReference type="eggNOG" id="arCOG11634">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_913995_0_0_2"/>
    <dbReference type="OMA" id="EIYEYER"/>
    <dbReference type="OrthoDB" id="134542at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="304" mass="34439" checksum="E69A7B879E31ADEA" modified="2013-03-06" version="1">MNNTIEDCTSILKRLYLKSRIINEIIQFFDVEPSLNPPNGLSLVLKSLHEPSIDEIPIYNTIVGSFNFNEIYEYERVAEIPKGDRINNLSLFIMDSYQKNRGIVAIIPSLLVIGLTSKLPENIINDLENSLLAEIEVSSENILYLPDRSYLPGNSIEIVAKSNSESSYERVEWLKNEAEKEGIKVENVKFLPDNKSIMDYIASGGIKGYLKRVPVTKIATMIVAASQCLNLEGVNDIVRREQSKHTIYTIGLTNEMLNELKESLIKNKIEGAPLLRISSNIEPFFNKGLIESMSEFLRRFGYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A833</accession>
    <name>L0A833_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231926.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0246"/>
    <dbReference type="EnsemblBacteria" id="AFZ70028">
        <property type="protein sequence ID" value="AFZ70028"/>
        <property type="gene ID" value="Calag_0246"/>
    </dbReference>
    <dbReference type="GeneID" id="14211506"/>
    <dbReference type="KEGG" id="clg:Calag_0246"/>
    <dbReference type="eggNOG" id="arCOG00826">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_36_1_2"/>
    <dbReference type="OMA" id="KELYVKP"/>
    <dbReference type="OrthoDB" id="124949at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="158" mass="18298" checksum="C8797F5F7B543D46" modified="2013-03-06" version="1">MFDTGMIVRKANKNDLQGLSELIYRFYAFNEEFDSSWAISPNAREEANKMAENMINDPNINVYVAVYDNLLIGYIKSITNENPLLINNKIEIIKELYVKPQMRRSGIASLLIQKLSEEISKKGVKYIAVEFPVQNWIATDLYKKLGFRPYSTTYIKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A851</accession>
    <name>L0A851_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231946.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0267"/>
    <dbReference type="EnsemblBacteria" id="AFZ70048">
        <property type="protein sequence ID" value="AFZ70048"/>
        <property type="gene ID" value="Calag_0267"/>
    </dbReference>
    <dbReference type="GeneID" id="14211527"/>
    <dbReference type="KEGG" id="clg:Calag_0267"/>
    <dbReference type="eggNOG" id="arCOG03660">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_726883_0_0_2"/>
    <dbReference type="OMA" id="MLMTTIP"/>
    <dbReference type="OrthoDB" id="73701at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="11"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="394" mass="44104" checksum="A1F6078BA05CBC0D" modified="2013-03-06" version="1" precursor="true">MDNKSSDVNNILISIAIVIILITFGVRASNNMIGTTMPLLAKKLFNFNNTKIGLLATIFMGFTFIMSNFINTKIKSKTRKKLFIISSIIYTLTFPLFYMSNQITIWLVAALAGFTIGALMPNLITSAGLFEDRRIRERMLAIYSLSLSTSLLIGPAIEGFILRYYTLRQSFLFFTIISALVPVLSPFLRFPDEDHESKIDTSFGKILKNNGFKVALLNNLTYQVPFAFILTFDGIYAENVFHASNSIAILLYSVFFITSFLGRLLLAIRPPSNIKLLIETSVTLTIIGLIVAFLSPNIYIFVVALLILGIPHGFTYTLSIITLSRTFDINLRNAANSYFFSTMMVIGAILPSLLGILVDITSLRIGFIAILPIIIAVFYVTEIYSRKTKELKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A868</accession>
    <name>L0A868_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0283</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231961.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0283"/>
    <dbReference type="EnsemblBacteria" id="AFZ70063">
        <property type="protein sequence ID" value="AFZ70063"/>
        <property type="gene ID" value="Calag_0283"/>
    </dbReference>
    <dbReference type="GeneID" id="14211543"/>
    <dbReference type="KEGG" id="clg:Calag_0283"/>
    <dbReference type="eggNOG" id="arCOG02935">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045717_5_0_2"/>
    <dbReference type="OMA" id="TPWHPHR"/>
    <dbReference type="OrthoDB" id="45486at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="21"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="191"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="301" mass="34019" checksum="4A3A5A8180F9F755" modified="2013-03-06" version="1">MERKRINIIYTAKETYDGAGVKLKRVFGGMRSVTYTDPFLLLDNFGSSNPEDYIMGFPWHPHRGIETVTYMLNGTVEHEDSEGNRGIIRPGEIQWMTAGSGIFHQEMPKPFEDRISLLKDNTVSGFQLWINLPASLKMTRPAYRSIKPDSIPSVDLDEGGKVKVIAGKYKNYEGALNYGGLKASNYIEPIYMDVNLEPEASFSYSVKPGFKAIIYPFVGYGLLNGMRIDSYRAYVLSEEGEQIDVKAGDMGVRFLLLAGKPIKERVAWYGPIVMNTQEQLEQAFLELSNGTFIKHREPEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A893</accession>
    <name>L0A893_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231954.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0276"/>
    <dbReference type="EnsemblBacteria" id="AFZ70056">
        <property type="protein sequence ID" value="AFZ70056"/>
        <property type="gene ID" value="Calag_0276"/>
    </dbReference>
    <dbReference type="GeneID" id="14211536"/>
    <dbReference type="KEGG" id="clg:Calag_0276"/>
    <dbReference type="eggNOG" id="arCOG04356">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038336_0_0_2"/>
    <dbReference type="OMA" id="VMIPDFR"/>
    <dbReference type="OrthoDB" id="60351at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008508">
        <property type="entry name" value="DUF790"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39640">
        <property type="entry name" value="PTHR39640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05626">
        <property type="entry name" value="DUF790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019435">
        <property type="entry name" value="UCP019435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="480" mass="56628" checksum="C9E61BE32C73E369" modified="2013-03-06" version="1">MFSTDLLRVKYRKDKVYLNYLSEENYDLVEEIMSVIKENILVGEFNEEIKYLKKAYDPKLVEGIATLLLRKSVIESKSPIDPKIIRSRIFSYGPIIDEKEKMKVLDKIKQDLGVDPMKYIFSDLEEEMVIKSVPKIDLEDLIREYNFELLQTALMKTLKVNVYISNKWKELLFNAKKLGLMYNAYSDPFNVEIYGPASLLRLTERYGRSISMLLPIIISNKNWRIKGEFVGKYNRVYLLEANSNDALFPLNQQQNISFDSSIEKDFYSKMKVVASDWEIIREPEPLIASNSVFIPDFLLVKNNVKIYVEIVGFWTKEYLRRKSEKVKEIKLPLILIVDESLGYEDFKNENVIKFKKSINIASVYYLINKIYDNLIKTNSIKYDYNIELKEDIVTFDEISKKFNIPKEKIREEGFNIKGYTKLKKIFIKNDFLQNLKDKDFNNLKLSQLINQYGDWILDVLDFFGYQIKWINITDAIVKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8I9</accession>
    <name>L0A8I9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232039.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0365"/>
    <dbReference type="EnsemblBacteria" id="AFZ70141">
        <property type="protein sequence ID" value="AFZ70141"/>
        <property type="gene ID" value="Calag_0365"/>
    </dbReference>
    <dbReference type="GeneID" id="14211625"/>
    <dbReference type="KEGG" id="clg:Calag_0365"/>
    <dbReference type="eggNOG" id="arCOG10177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2392736_0_0_2"/>
    <dbReference type="OMA" id="DFREMRV"/>
    <dbReference type="OrthoDB" id="138711at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="93" mass="10999" checksum="A031AF778050C8EC" modified="2013-03-06" version="1">MDKKICNRCVNWRPHVQYPFIGLCIKLGKLTVDDDTCSFFEEVNIKSNEFYWIPEMKTRVFGDEAKIFLKNGYRVFLGAYVDPDVREEIYGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8K9</accession>
    <name>L0A8K9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase small subunit PriS</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">priS</name>
        <name evidence="13" type="ordered locus">Calag_0395</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="12">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232064.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0395"/>
    <dbReference type="EnsemblBacteria" id="AFZ70166">
        <property type="protein sequence ID" value="AFZ70166"/>
        <property type="gene ID" value="Calag_0395"/>
    </dbReference>
    <dbReference type="GeneID" id="14211655"/>
    <dbReference type="KEGG" id="clg:Calag_0395"/>
    <dbReference type="eggNOG" id="arCOG04110">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056123_0_0_2"/>
    <dbReference type="OMA" id="GYHVHVR"/>
    <dbReference type="OrthoDB" id="95578at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00700">
        <property type="entry name" value="DNA_primase_sml_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023639">
        <property type="entry name" value="DNA_primase_ssu_PriS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="PTHR10536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 10 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 10 11" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ70166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="354" mass="40748" checksum="8191CA1FBDA5D3C7" modified="2013-03-06" version="1">MVQEEREIKIKEWKGEQTIKYLYKEYYSLIPPLILPKDIERREFAIQPFDKQSYIRHLSFDNQQKFYDFLIKSTPKHVYYSIGIYDLPEANSMEEKGWKGSDLLFDIDLDHDKSCQTQDDITDDLCIEKGLKYAETIASMINNYFGGYHQIYFTGNRGYHVRGICENCRLLGREERAEIAKFVMAQDLDLEIIFPKSSKGKKSAPPSPKDPGWRGLIASYGIKEVDAVEIKNAIENIRVEIDSMVTQDPSRLTRIPGTLNGKSSLLVVPICGEFKLGKWLSPFYGEIEVKALKDLQKLKILGINIEFRKNEELSIPSQHAIYLATKGYLNILGGNLVVRKNTGWWPIQGCNWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8P5</accession>
    <name>L0A8P5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative GTPase, probable translation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232141.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0477"/>
    <dbReference type="EnsemblBacteria" id="AFZ70243">
        <property type="protein sequence ID" value="AFZ70243"/>
        <property type="gene ID" value="Calag_0477"/>
    </dbReference>
    <dbReference type="GeneID" id="14211737"/>
    <dbReference type="KEGG" id="clg:Calag_0477"/>
    <dbReference type="eggNOG" id="arCOG00357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037276_1_0_2"/>
    <dbReference type="OMA" id="QIDCACA"/>
    <dbReference type="OrthoDB" id="51913at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="MMR_HSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="MMR_HSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="6"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="3">
        <location>
            <begin position="328"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="409" mass="45322" checksum="90B9B446E32C69AB" modified="2013-03-06" version="1">MEPTNALIGVVGKTNVGKSTFFSAATEIDVPIENRPFVTIEPNVGIGYARKKCVHVELGLPSCNAANSVCRNGERFIPVKLMDVAGLVPGAHQGRGLGNKFLDDLRRADVFLLIVDASGSTSPEGVVSSPGTYDPIEEIKFVITEIDEWIYQSVEKDWDKFLKQYSIGAIKDPLESFSQRLSGFGINKEQVEMALNNLKISYNELFKISKEDLKNLLKEIRRLTKPMVIVANKIDIPESEKNLEKIRNYFKEYPVVPASAAAELFLRKLGKKNAIDYIPGDYDFKIKAGEIDSKTKGILELIKNNIMDKFKGTGVVQSINEALFNSLKLIPVYPVEDINKFTDKKNRVLPDVILIPKGSTAKDLAGKIHTDLANTFLYAINAKNKQRIGANYLLNENDVIKIVAASGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8U4</accession>
    <name>L0A8U4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232169.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0507"/>
    <dbReference type="EnsemblBacteria" id="AFZ70271">
        <property type="protein sequence ID" value="AFZ70271"/>
        <property type="gene ID" value="Calag_0507"/>
    </dbReference>
    <dbReference type="GeneID" id="14211767"/>
    <dbReference type="KEGG" id="clg:Calag_0507"/>
    <dbReference type="eggNOG" id="arCOG13725">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2243687_0_0_2"/>
    <dbReference type="OMA" id="WAIASCE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="104" mass="11519" checksum="F8996058D0C4E02B" modified="2013-03-06" version="1">MISTTEFEVVYEDPSNLLKGFEMIKNYIDSLNCLATKSSAWAIASCEDIFIKAKIDIEESLNLQTITKASINVKLEGNTNEIVKMTSELTKIIRDSGGGIILRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8V0</accession>
    <name>L0A8V0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps13</name>
        <name evidence="6" type="ordered locus">Calag_0548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232206.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0548"/>
    <dbReference type="EnsemblBacteria" id="AFZ70308">
        <property type="protein sequence ID" value="AFZ70308"/>
        <property type="gene ID" value="Calag_0548"/>
    </dbReference>
    <dbReference type="GeneID" id="14211808"/>
    <dbReference type="KEGG" id="clg:Calag_0548"/>
    <dbReference type="eggNOG" id="arCOG01722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_0_0_2"/>
    <dbReference type="OMA" id="IRAYRGI"/>
    <dbReference type="OrthoDB" id="84219at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019977">
        <property type="entry name" value="Ribosomal_S13_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03629">
        <property type="entry name" value="uS13_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="164" mass="18682" checksum="430F42D0A6D8253C" modified="2013-03-06" version="1">MPTKGEKEEQFKYVLRIAETDINGNLNVILGLSKIKGIGYQTALAIVRHLGIDPKKRIGYLSNEELKSLEDVLNDLTKLKLPNWMYNRRKDYETGLDKHLIGAELIFVARRDVEREQKVNSWRGVRHKLGLKVRGQKTHTTGRLGMTIGVKKEKVETSGGSQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A911</accession>
    <name>L0A911_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232276.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0623"/>
    <dbReference type="EnsemblBacteria" id="AFZ70378">
        <property type="protein sequence ID" value="AFZ70378"/>
        <property type="gene ID" value="Calag_0623"/>
    </dbReference>
    <dbReference type="GeneID" id="14211883"/>
    <dbReference type="KEGG" id="clg:Calag_0623"/>
    <dbReference type="eggNOG" id="arCOG05323">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1323954_0_0_2"/>
    <dbReference type="OMA" id="MKCNPRF"/>
    <dbReference type="OrthoDB" id="60730at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="215" mass="24343" checksum="A88CB662325BED32" modified="2013-03-06" version="1">MATSKVVLIGINSLSYGEFMICKPKTLLYLLGNSFRGVVENNPPKDAISSWLSIFSLNRTNNNESINKLDDLPLIKLVNPILINIPISNPTYGRVNIKLDQSISYQEEIDTVMNEIMENQENGPIISGITALERIDDKSCEIYNAIDKMLLNVIRNVDEFIIFSPYGMKKGKINEPYGVYLSSRPRPNEHDTVKLWEIGQIFVDIVKGDNVQDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0A922</accession>
    <name>L0A922_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231822.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0136"/>
    <dbReference type="EnsemblBacteria" id="AFZ69924">
        <property type="protein sequence ID" value="AFZ69924"/>
        <property type="gene ID" value="Calag_0136"/>
    </dbReference>
    <dbReference type="GeneID" id="14211396"/>
    <dbReference type="KEGG" id="clg:Calag_0136"/>
    <dbReference type="eggNOG" id="arCOG00856">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_2"/>
    <dbReference type="OMA" id="HDDYAYQ"/>
    <dbReference type="OrthoDB" id="13052at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="463"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="557" mass="63642" checksum="1159640C150B9BC9" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A943</accession>
    <name>L0A943_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum cofactor biosynthesis protein MoaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0662"/>
    <dbReference type="EnsemblBacteria" id="AFZ70413">
        <property type="protein sequence ID" value="AFZ70413"/>
        <property type="gene ID" value="Calag_0662"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0662"/>
    <dbReference type="eggNOG" id="arCOG01530">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074693_1_2_2"/>
    <dbReference type="OMA" id="IWDMVKS"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="3">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="146" mass="15967" checksum="685FE17156BA5727" modified="2013-03-06" version="1">MAQMVDVTNKPIIYREAVASGEIKLREETIKRILNKEIEKGDVEAVASVASIMAAKDASKIIPLAHPLPITGVSVNFSYDKNTVKITVKVKTKAETGVEMDALAGVTAGLLAVWDMVKQYEKDSLGMYPNTMITNVKVESKIKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A960</accession>
    <name>L0A960_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavin-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232304.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0655"/>
    <dbReference type="EnsemblBacteria" id="AFZ70406">
        <property type="protein sequence ID" value="AFZ70406"/>
        <property type="gene ID" value="Calag_0655"/>
    </dbReference>
    <dbReference type="GeneID" id="14211915"/>
    <dbReference type="KEGG" id="clg:Calag_0655"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066799_0_0_2"/>
    <dbReference type="OMA" id="EEFPRYK"/>
    <dbReference type="OrthoDB" id="31233at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="351" mass="38820" checksum="E280653264CD2F81" modified="2013-03-06" version="1" precursor="true">MKEINIIGAGPAGAAAAYALSKHGYKVKIYEANKRLAMKPCGLGIPSVKDLPFKISKQFVLKTVNGVELYVDEKKVLDKENFLEGYIIDKENFLESLIAESGAEIYKNSGYNPLRNTVRENGNIKEVKEGIIAGGFSFYNGEKINAIQTIAKSKDIEDLRKLIIFFDTEIIGYYWIFPTEDGVEVGVGGYRSTEELSTLLNKFIKSNELLANSTTYDIKGAQIAVGGVDLNFNDNLIKIGEAAGFVLPLTGEGIRPSLISGIEAANAINEGKNVKNHLHNLKITNAIRIQRRILVRVKSMDRQRRRELLSSMPAEVHAEVALGNMNKLKIIKALASRPDLAIKLINYMSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A974</accession>
    <name>L0A974_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232346.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0703"/>
    <dbReference type="EnsemblBacteria" id="AFZ70448">
        <property type="protein sequence ID" value="AFZ70448"/>
        <property type="gene ID" value="Calag_0703"/>
    </dbReference>
    <dbReference type="GeneID" id="14211963"/>
    <dbReference type="KEGG" id="clg:Calag_0703"/>
    <dbReference type="eggNOG" id="arCOG02738">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167327_0_0_2"/>
    <dbReference type="OMA" id="EEMYAEA"/>
    <dbReference type="OrthoDB" id="110383at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="110" mass="12540" checksum="C385FAEB6E3EF0E0" modified="2013-03-06" version="1">MRIALVYDEEQNLKPLDEGEILAIIDEEQEVVEQYENPGFKIGKDVTMDAILQLGAQAVIVKQGYLDQKSYDLSKGHLSYMLINKYDTLTDIIENLDDVKSKAIDELTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9A6</accession>
    <name>L0A9A6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <shortName evidence="8">GAPDH</shortName>
            <ecNumber evidence="8 10">1.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gap</name>
        <name evidence="12" type="ordered locus">Calag_0739</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8 10">
            <text>D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8 10">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.59" evidence="8 10"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232380.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0739"/>
    <dbReference type="EnsemblBacteria" id="AFZ70483">
        <property type="protein sequence ID" value="AFZ70483"/>
        <property type="gene ID" value="Calag_0739"/>
    </dbReference>
    <dbReference type="GeneID" id="14211999"/>
    <dbReference type="KEGG" id="clg:Calag_0739"/>
    <dbReference type="eggNOG" id="arCOG00493">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069533_0_0_2"/>
    <dbReference type="OMA" id="NAIVPNP"/>
    <dbReference type="OrthoDB" id="32079at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047100">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00559">
        <property type="entry name" value="G3P_dehdrog_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006436">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01546">
        <property type="entry name" value="GAPDH-II_archae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="11">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="8">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="8">
        <location>
            <begin position="197"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="14"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="343" mass="37802" checksum="94C0A310DE4E0977" modified="2013-03-06" version="1">MKSKVKVAINGFGTIGKRVAIAINKQDDMVVSGIVKIKPDYNALFAKRMGMNIYTIDKEDANEFKKKGIEVYGTIEDLIKESDIIVDATPDGVGENYKKLYNKYGINSIFQGGEEANIADISFNALCNYDEAYGKKSIRVVSCNTTGLLRSICALSNLSKIEKVNAVLIRRGADPQEIKKGPINSIVLNPVGLPSHHALDVKTVIPWINISTAAVVVPTTLMHVHHVTIRFSNKVEKNDILEALMNSPRIILVDSAISGIQSTSQIIDSARLSKERGDINELVVFKDSITVDDNEVQFFQAVHQESIVVPENIDAIRASLELSSKMESINKTDKKLGINKILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9F2</accession>
    <name>L0A9F2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Zn-finger containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231947.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0268"/>
    <dbReference type="EnsemblBacteria" id="AFZ70049">
        <property type="protein sequence ID" value="AFZ70049"/>
        <property type="gene ID" value="Calag_0268"/>
    </dbReference>
    <dbReference type="GeneID" id="14211528"/>
    <dbReference type="KEGG" id="clg:Calag_0268"/>
    <dbReference type="eggNOG" id="arCOG00578">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142653_1_0_2"/>
    <dbReference type="OMA" id="EIVCPVH"/>
    <dbReference type="OrthoDB" id="99528at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06677">
        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="127" mass="14575" checksum="358BFF3DDCD79246" modified="2013-03-06" version="1">MSNKQDLRDNPEVVKKMTSLLAQGAAMLDKTCPVCGLPLFQTKKGEIVCPVHGKVYVVESEEEAKDIEVDETLKSLEYFISIKIRENINKDDIDEISDLLKIMESTERIIMLRKDIFSKQNQKEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9F3</accession>
    <name>L0A9F3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232398.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0757"/>
    <dbReference type="EnsemblBacteria" id="AFZ70501">
        <property type="protein sequence ID" value="AFZ70501"/>
        <property type="gene ID" value="Calag_0757"/>
    </dbReference>
    <dbReference type="GeneID" id="14212017"/>
    <dbReference type="KEGG" id="clg:Calag_0757"/>
    <dbReference type="eggNOG" id="arCOG04280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_1_2"/>
    <dbReference type="OMA" id="DHLVMIT"/>
    <dbReference type="OrthoDB" id="61440at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="317" mass="34828" checksum="9F1C104CD038E042" modified="2013-03-06" version="1">MKVIAIDIGATNLRVALFENNSKINEIKVKTPRDDPNSISKSIIKMINELSPNRDFQSIGIGTIGPLNLKKGIIELAPNLGLKNIPLRDPLVNEFHKDVYIANDAMAAVWAEKILGDAKNKNDLVYITMSSGIGVGAIIDGNLIVGRRGNSHEMGHSLVKFDSNLVCGCGKIGHWEAYAGGKNIPKVAKEFANEWKGKESEGYFLAKENNLTPEKLYDLARKNDEFSKSLVDFLNIIHAAGISNIIAAYDPEVIYIGGSIYLYNEDLIKPYLIKYIPMFSALGVPEIKMCTFGDDQVLYGAASIAINPPSQIKKFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9H6</accession>
    <name>L0A9H6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232445.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0807"/>
    <dbReference type="EnsemblBacteria" id="AFZ70548">
        <property type="protein sequence ID" value="AFZ70548"/>
        <property type="gene ID" value="Calag_0807"/>
    </dbReference>
    <dbReference type="GeneID" id="14212067"/>
    <dbReference type="KEGG" id="clg:Calag_0807"/>
    <dbReference type="eggNOG" id="arCOG00853">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034446_2_1_2"/>
    <dbReference type="OMA" id="RTVNTEM"/>
    <dbReference type="OrthoDB" id="18649at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="3">
        <location>
            <begin position="23"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="2">
        <location>
            <begin position="168"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="450" mass="49826" checksum="9269EAFF420300DF" modified="2013-03-06" version="1">MSEGESATAEWYKLSVELHRYYGGKIEIIPKVPVRRLKDFAIWYTPGVAEASRLSSKNPDLSFELTSRWNTIAVVSDGTRVLGLGNIGPEGAYPVMEGKALIYKYLGGVDAVPLVHRARDPNRFLQLLEDIEPSYGGINLEDIESPKCFYILDEARKRLKIPVWHDDQQGTATIILAGLINALKVVKKSIKDVRIVIVGAGAANTAFYRLLKGIKSDLENIVVVEKNGILHPEMPNIDKLMISNKWQYDIAIETKGGGLPPNSTIDKAFENADVVIAASTPGPDTLKKEWVSKMNKDAIVFALANPVPEIWPQDAKKAGAKIVATGRSDFPNQINNSLVFPAIFRGVLDVRAKTISDTMAITAAYEIAKFAEEKGLSENYIVPTMEEWEVYPRVAAAVAVKAVEEGVARKTTTYKEELDNATYMISLSRKKLETVYQRGLIKDPLIDYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9L8</accession>
    <name>L0A9L8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol monophosphatase/fructose-1,6-bisphosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0045"/>
    <dbReference type="EnsemblBacteria" id="AFZ69837">
        <property type="protein sequence ID" value="AFZ69837"/>
        <property type="gene ID" value="Calag_0045"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0045"/>
    <dbReference type="eggNOG" id="arCOG01349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_5_0_2"/>
    <dbReference type="OMA" id="RWGDERY"/>
    <dbReference type="OrthoDB" id="99063at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="264" mass="29465" checksum="0A37F0FE2C32EB4F" modified="2013-03-06" version="1">MIDNEELRKIVIDVAYESVKYLRNNFCNNDAIKLIRGETIRADLESEKIVNEVIKSYDLDYKIVTEESNIIGNGKYTFILDPLDGSINFENCIPWSSVSLAVLPPNKNKVSDAIAGVVYPVYFNGLPFSYSKGNGCFEGNNKVKMSNEESKILFAYLEKEDEAYKLAKLISKKKGLKIRSLGSSALELIFTGLGRSYAFIDLRGKLRNVDVAAAIGFIRECEGYVVNSKGENADVNAEKVDVIGDIIATNNKNRLDEILNYINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9R3</accession>
    <name>L0A9R3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Na+/H+ antiporter NhaD-like permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_0380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232052.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0380"/>
    <dbReference type="EnsemblBacteria" id="AFZ70154">
        <property type="protein sequence ID" value="AFZ70154"/>
        <property type="gene ID" value="Calag_0380"/>
    </dbReference>
    <dbReference type="GeneID" id="14211640"/>
    <dbReference type="KEGG" id="clg:Calag_0380"/>
    <dbReference type="eggNOG" id="arCOG00238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011920_3_0_2"/>
    <dbReference type="OMA" id="SWGYYFK"/>
    <dbReference type="OrthoDB" id="49249at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="32"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="426" mass="47749" checksum="9FE79C483EB4B748" modified="2013-03-06" version="1">MNVKEFFGGIILLIIIIGLIMRAKFTKIPSWSIMSLAASITILFGLVPIYNVSNIIDWNVILFLISMFSIISIAETSGLLDYLAAYLVSSFKSRILLLYLLALFFGLLSSIMVNDAVAIVGTSLSVIIAKSLELPFEPLIILVAFSITIGSVMTPLGNPQNMLIATETNINAPLLTFLKYLAIPTIINLFLTTYFIIKYYKIKELKKEFFMGVPQEYIKNKRDAYISLIAIIIIIISLLVNDFLELYKLPHVTSIGLIPFTIAAFIYIFVSDPRQTLSKVNWGTIIFFITMFIATQGIWNSGILYEPLHLLLPHYMRGVNNILRISASSLIFSQLISNVPFTNLFIVYMNNLGYTYANVISWITLAMATTIAGNLTILGAASNIIIIDNLESKYGITITYKDFMKIGIPITLINLIVYIVYIILIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9R8</accession>
    <name>L0A9R8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0856"/>
    <dbReference type="EnsemblBacteria" id="AFZ70596">
        <property type="protein sequence ID" value="AFZ70596"/>
        <property type="gene ID" value="Calag_0856"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0856"/>
    <dbReference type="eggNOG" id="arCOG11224">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1718119_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="152" mass="17895" checksum="305EDB70F2F1B77F" modified="2013-03-06" version="1">MKIIKIPVIKIVFINIIPKLPFKIYNQYGNDKKGSPINYFLSITRNQNIKSSEDIVNMIYNEINRLCIGLRMVLDSHFYSKYGKNYVEILISNPYLAYNESLKILSEDSVRLIFKTILKTFNINHYEIEMIINEISKGNDRALKQDFHHNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9X3</accession>
    <name>L0A9X3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232590.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0970"/>
    <dbReference type="EnsemblBacteria" id="AFZ70693">
        <property type="protein sequence ID" value="AFZ70693"/>
        <property type="gene ID" value="Calag_0970"/>
    </dbReference>
    <dbReference type="GeneID" id="14212230"/>
    <dbReference type="KEGG" id="clg:Calag_0970"/>
    <dbReference type="eggNOG" id="arCOG05477">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1458136_0_0_2"/>
    <dbReference type="OMA" id="CYEMAIV"/>
    <dbReference type="OrthoDB" id="88516at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="185" mass="21326" checksum="BD3A4BCC11993179" modified="2013-03-06" version="1">MVDIIGKYRDGGINYTFRYASREDKKRIIEFYESMDNESIYFRFLSFFKDFSSHVEKIFSEKNKYGFAVIGEDEKGNIAALGENFSYSLESAELAFIVSPNHRRRGLGSIVAAFLILGSYARGIKIMEAYFHAENSPAYKIGLKMGLNMDFEEDVYHGKAPLEKIYKIALNALREKNVELYMNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Y0</accession>
    <name>L0A9Y0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="ordered locus">Calag_0980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232600.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0980"/>
    <dbReference type="EnsemblBacteria" id="AFZ70703">
        <property type="protein sequence ID" value="AFZ70703"/>
        <property type="gene ID" value="Calag_0980"/>
    </dbReference>
    <dbReference type="GeneID" id="14212240"/>
    <dbReference type="KEGG" id="clg:Calag_0980"/>
    <dbReference type="eggNOG" id="arCOG01303">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_2_2"/>
    <dbReference type="OMA" id="YRDSHEW"/>
    <dbReference type="OrthoDB" id="96879at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="139" mass="15769" checksum="996623E65BC69C44" modified="2013-03-06" version="1">MSRYQVKVGNQNVIIDDSLLYTKSDEWVKFEGDKIRIGITDYAQKQLKDIVGVDLPKKGSNINKNGTLAVLESVKATAEVYSPIEGKVLDVNERLLDEPELINKEPYDNGWIALIEAKSIDKNEFLDHKSYVDDIAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Y3</accession>
    <name>L0A9Y3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0161"/>
    <dbReference type="EnsemblBacteria" id="AFZ69947">
        <property type="protein sequence ID" value="AFZ69947"/>
        <property type="gene ID" value="Calag_0161"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0161"/>
    <dbReference type="eggNOG" id="arCOG13702">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_671936_0_0_2"/>
    <dbReference type="OMA" id="GENEGMG"/>
    <dbReference type="OrthoDB" id="133669at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="52"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="409" mass="44633" checksum="4BCF04B6A030AC41" modified="2013-03-06" version="1" precursor="true">MINMANLVKLLAIIFLVLALIGFGLFAYEYNIKNTPQTNKSNNSFLFNTPMIGIVTPMAMEQAPILAQMKNVTEINISGYTFYVGKIGNQWVVNVRSGEKEYAAEMATYIMDTHFHIIANILSGTAGSRNPYILPGDVVIGAYVVDKSSIHYHNRGFQSDYTGVEMVVNNKSLIQNAVIGGYGEIGPTLQNASYYGYGPGTNDLSYVYVAALPASLGLVQIAENAPIGYISIANATGNSSLSGIVKSQIIVGVIGSANQWTEPLTWMEDQNALYQSDAGENEGMGFAYVNAELGIPWIIVRGISDSPWFPNAYIGVIAAQRAANVTIFIVEHFSQNNLYKTVNMSVLSNISNAVLNGYLIALRAYYSVGNVTMIKYQLQNGTIITVVNPNEVEYTYGFGYKILEARNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Y4</accession>
    <name>L0A9Y4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribbon-helix-helix protein, copG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232605.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70708">
        <property type="protein sequence ID" value="AFZ70708"/>
        <property type="gene ID" value="Calag_0985"/>
    </dbReference>
    <dbReference type="GeneID" id="14212245"/>
    <dbReference type="KEGG" id="clg:Calag_0985"/>
    <dbReference type="eggNOG" id="arCOG13733">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_206914_0_0_2"/>
    <dbReference type="OMA" id="QNYIMAD"/>
    <dbReference type="OrthoDB" id="142949at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="56" mass="6760" checksum="9CCD2C7F274EC6CD" modified="2013-03-06" version="1">MKVVSFKLEEDLLEILEEYSKKRNVPKSEIIRRALQNYIMADKDKPFVTKRIKIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA05</accession>
    <name>L0AA05_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232583.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0961"/>
    <dbReference type="EnsemblBacteria" id="AFZ70686">
        <property type="protein sequence ID" value="AFZ70686"/>
        <property type="gene ID" value="Calag_0961"/>
    </dbReference>
    <dbReference type="GeneID" id="14212221"/>
    <dbReference type="KEGG" id="clg:Calag_0961"/>
    <dbReference type="eggNOG" id="arCOG00894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_3_2"/>
    <dbReference type="OMA" id="VCILIPT"/>
    <dbReference type="OrthoDB" id="96698at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="297" mass="34157" checksum="F3EE659EF2969779" modified="2013-03-06" version="1">MEQINNLNVIIPTLNEEDGIGLTIDEITQYVNKENIIVVDGNSKDNTKNEVEKRGVKFFIQKGKGKAEAIKEALNHVNKEIVLIIDGDYTYPAKYIKEMHSILMNDEEVDEVIGVRNRKNQSIVYRFGNWFLTNFFSLLFGVHLNDVLSGMYMIRKRALEGALFEMRGFSVESEIAAHISSTGNKIAQVNIDYRERKGKKKLGIRHGIKIAIDMLRLSWRYNPVTLFFFVGSLLMIPGLIIGFYTVYDYVFLHIDHFVKAIIALILTATGFQSLMLSILSMYLKRMELRIKSYLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA15</accession>
    <name>L0AA15_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232162.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0498"/>
    <dbReference type="EnsemblBacteria" id="AFZ70264">
        <property type="protein sequence ID" value="AFZ70264"/>
        <property type="gene ID" value="Calag_0498"/>
    </dbReference>
    <dbReference type="GeneID" id="14211758"/>
    <dbReference type="KEGG" id="clg:Calag_0498"/>
    <dbReference type="eggNOG" id="arCOG01278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_4_0_2"/>
    <dbReference type="OMA" id="DGGCIAN"/>
    <dbReference type="OrthoDB" id="44046at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="2">
        <location>
            <begin position="268"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="380" mass="40331" checksum="ED7B2491BB58ED0A" modified="2013-03-06" version="1">MVVYVEGVGMTKIDRHYDYSLKDLAAKAAFNAIDQSGGADGIDYLIFSSSLASLQDSQLDSASYLATSLGLKGVRALNIEAGEASGLAAISVAKSLLESHQADKVLVVGAEKLNEFVSSKVYKQLQMLYDGDTKSFYNIGFAGEAALLMRLYMDTYNINRDTMSYWPALMHSNAKENPYAMLNFAIKPDKVAKSQILADPITLLDSYPLGDGAAAVVLSNRDVARSPIAKISAIESSTGYGSIEMSDDPLQFDSLSDAYRRISNIADLSNIDFIEIHDSFTITAMIILETLGFANRGKAAELVSTGYFSPGGKGPVANPSGGLKARGHPLGATGIYQIAESSLQVSGKFPGIKISNAKKGLVVSLNGLGSSAYVALVEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA54</accession>
    <name>L0AA54_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232202.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0544"/>
    <dbReference type="EnsemblBacteria" id="AFZ70304">
        <property type="protein sequence ID" value="AFZ70304"/>
        <property type="gene ID" value="Calag_0544"/>
    </dbReference>
    <dbReference type="GeneID" id="14211804"/>
    <dbReference type="KEGG" id="clg:Calag_0544"/>
    <dbReference type="eggNOG" id="arCOG13723">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1736326_0_0_2"/>
    <dbReference type="OMA" id="RIMKGTI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="150" mass="16731" checksum="82D413F3C9F9EC31" modified="2013-03-06" version="1">MDKKKIYWIIKQILLGILEGILYSIVYIYLLPFLLTLISSTLSNQITAITSLLPSEIYIYIGLFVGLDVVARIMKGTIYNPLLRATSSLLGLLIILSYFNNGILSAGPITINGVQAYITLNLSIILLIYIAFIIAPGIIIPFIEYFVENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA63</accession>
    <name>L0AA63_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative solute binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232690.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1071"/>
    <dbReference type="EnsemblBacteria" id="AFZ70793">
        <property type="protein sequence ID" value="AFZ70793"/>
        <property type="gene ID" value="Calag_1071"/>
    </dbReference>
    <dbReference type="GeneID" id="14212331"/>
    <dbReference type="KEGG" id="clg:Calag_1071"/>
    <dbReference type="eggNOG" id="arCOG01672">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010991_0_0_2"/>
    <dbReference type="OMA" id="YNDTRYE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="878"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="34"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="900" mass="98378" checksum="EB2780C3ADA15AC8" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA81</accession>
    <name>L0AA81_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1091</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232710.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1091"/>
    <dbReference type="EnsemblBacteria" id="AFZ70813">
        <property type="protein sequence ID" value="AFZ70813"/>
        <property type="gene ID" value="Calag_1091"/>
    </dbReference>
    <dbReference type="GeneID" id="14212351"/>
    <dbReference type="KEGG" id="clg:Calag_1091"/>
    <dbReference type="eggNOG" id="arCOG01601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058423_0_0_2"/>
    <dbReference type="OMA" id="ATGCMEV"/>
    <dbReference type="OrthoDB" id="29720at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="54"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="320" mass="35267" checksum="BEC87EE9E78AEAAC" modified="2013-03-06" version="1">MSENKILRIKSLYDLPRDELFISGHGLCPGCTAGTIMRMLTKVTGKDTIIVNATGCVEVSTTRYPYSNWLVPWFHSAFENSGASASGIAAAIKAMKRKGLMDKNKDVKVVVVAGDGGTVDIGLQSLSGMLERKEPVMYVLYDNEAYMNTGIQRSGSTPHGAWTTTTPAGKVWRGEWRDKKDIAGIAAAHHIPYVATANPAYPMDMINKFARGLEVLNEGPSFIQVLMACTTGWRFDPALGITISRLATETGIFPLYEIDHDNFRVTFPVMKRKPVKEYLKLQGRFAHLTDDEINEIQKLVDQKVEAINKRAGKTVIGPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAA9</accession>
    <name>L0AAA9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP:adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232740.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1121"/>
    <dbReference type="EnsemblBacteria" id="AFZ70843">
        <property type="protein sequence ID" value="AFZ70843"/>
        <property type="gene ID" value="Calag_1121"/>
    </dbReference>
    <dbReference type="GeneID" id="14212381"/>
    <dbReference type="KEGG" id="clg:Calag_1121"/>
    <dbReference type="eggNOG" id="arCOG01871">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098907_1_0_2"/>
    <dbReference type="OMA" id="ISWAFDA"/>
    <dbReference type="OrthoDB" id="90478at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="177" mass="20186" checksum="FD27483586A2771C" modified="2013-03-06" version="1">MVFDADIAIIMAGGKGKRFGSSFKPFIEICGKPMIFNIIDKTKKLFKFNIIAISENVENFLYILKNKYKDLLLIYTTGIDYSIDLKIVLDMIKKRPIIVFPSDIPFIKENTIEEIILLSRGMNEDLITILNKQGEPVGISIIKGNDLNRWTNLKLNEDLININTKDDLNNAKVICND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAC9</accession>
    <name>L0AAC9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232723.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1104"/>
    <dbReference type="EnsemblBacteria" id="AFZ70826">
        <property type="protein sequence ID" value="AFZ70826"/>
        <property type="gene ID" value="Calag_1104"/>
    </dbReference>
    <dbReference type="GeneID" id="14212364"/>
    <dbReference type="KEGG" id="clg:Calag_1104"/>
    <dbReference type="eggNOG" id="arCOG00349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_9_1_2"/>
    <dbReference type="OMA" id="PDDMKDC"/>
    <dbReference type="OrthoDB" id="111853at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="79" mass="8872" checksum="BE66E221726A38FC" modified="2013-03-06" version="1">MTLRVWEEPRDNCIADMVCVSLCGDVFEMSDVDGKANIIAKWRKDPDKINEGFVPDDMKDCVEAAVQSCPTQIIHMEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAD3</accession>
    <name>L0AAD3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231898.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0218"/>
    <dbReference type="EnsemblBacteria" id="AFZ70000">
        <property type="protein sequence ID" value="AFZ70000"/>
        <property type="gene ID" value="Calag_0218"/>
    </dbReference>
    <dbReference type="GeneID" id="14211478"/>
    <dbReference type="KEGG" id="clg:Calag_0218"/>
    <dbReference type="eggNOG" id="arCOG13716">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2447505_0_0_2"/>
    <dbReference type="OMA" id="PPWIRSA"/>
    <dbReference type="OrthoDB" id="143779at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="89" mass="10335" checksum="C8ADDC2B97DCF55B" modified="2013-03-06" version="1">MRLPRTWIDSSRKNEENYEARITVEIYPGVNFKIYINKLAQKPVFACCTGRENKICNSYIISLFSQSGPFASLYILPPWLVSKCKEKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAE8</accession>
    <name>L0AAE8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="8" type="ordered locus">Calag_0233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 6">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231913.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0233"/>
    <dbReference type="EnsemblBacteria" id="AFZ70015">
        <property type="protein sequence ID" value="AFZ70015"/>
        <property type="gene ID" value="Calag_0233"/>
    </dbReference>
    <dbReference type="GeneID" id="14211493"/>
    <dbReference type="KEGG" id="clg:Calag_0233"/>
    <dbReference type="eggNOG" id="arCOG04137">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_2"/>
    <dbReference type="OMA" id="NKYGCRE"/>
    <dbReference type="OrthoDB" id="17629at2157"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="7">
        <location>
            <begin position="186"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="215"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="294"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="416" mass="46110" checksum="3AF5693A43557C23" modified="2013-03-06" version="1">MNSSKIKKPELFNEGNKKIEFAEMHMPVVMKIRERFLREKPLDGVKISAALHVTKETAVLIKTLSVWGANIFLSPSNPLSTQDDVAASLAKIDNIVVEAWRGMSSEEYFMAIKDAANFKPDIVIDDGADLHITLHEEMPKIAEKVIGGNEETTTGVIRLKALEKENRLLYPVIAVNNALTKFMFDNRYGTGQSSIDGILRATNILIAGKRAVVAGYGWVGRGIALRLKGMGARVIVTEVDPIKALEAVMDGFDVMTMEEASKIGDIFITATGDIDVIRAEHMLNMKDGAILANAGHFNVEVSVKDLEKISDSKEEIRENTVKYTLRNGKHLFLLGEGRLVNLVAAEGHPSEVMDMSFANQALSVLYLINNKGKLEKKVYNVPSDQDQYVAKLKLETMGIKIDELTPEQVKYLESYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAF6</accession>
    <name>L0AAF6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl6</name>
        <name evidence="5" type="ordered locus">Calag_1177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1177"/>
    <dbReference type="EnsemblBacteria" id="AFZ70898">
        <property type="protein sequence ID" value="AFZ70898"/>
        <property type="gene ID" value="Calag_1177"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1177"/>
    <dbReference type="eggNOG" id="arCOG04090">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_0_0_2"/>
    <dbReference type="OMA" id="VFQDGIY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_A">
        <property type="entry name" value="Ribosomal_L6_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_L6_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019907">
        <property type="entry name" value="Ribosomal_L6P_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03653">
        <property type="entry name" value="uL6_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="4">
        <location>
            <begin position="16"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="4">
        <location>
            <begin position="102"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="185" mass="20842" checksum="6173EB9D1C564DA6" modified="2013-03-06" version="1">MLTLAKEVHAIRELEIPDGIDIKIDGKKIKVKGPKGELERDFSHIKDLSLRLEDKKLIAEVYFADAKKKAVVGTVIAHVKNMITGVTKGYRYKLKIIYSHYPISVKKDGNKIIISNFIGEKSPRIAKVFPGVNVKVQGTDIILEGIDIEKVSQSAANIELATKISDFDRRKFMDGIYIYSREVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAH7</accession>
    <name>L0AAH7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-amylase/alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232332.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0689"/>
    <dbReference type="EnsemblBacteria" id="AFZ70434">
        <property type="protein sequence ID" value="AFZ70434"/>
        <property type="gene ID" value="Calag_0689"/>
    </dbReference>
    <dbReference type="GeneID" id="14211949"/>
    <dbReference type="KEGG" id="clg:Calag_0689"/>
    <dbReference type="eggNOG" id="arCOG03278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033691_0_0_2"/>
    <dbReference type="OMA" id="GWRSPNY"/>
    <dbReference type="OrthoDB" id="45403at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="1">
        <location>
            <begin position="43"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="471" mass="55950" checksum="2137713531245B80" modified="2013-03-06" version="1">MEIALLFEMHQPARLKKLSEFPPTSIPENLDEIFDNYTDKIILDRVTERTYRHATKILKNNIEKYKDFKINFSISGILLEQLNKNYKDVIKLFQDLANTERVEFLSQTYYHSLAWFIDKREFYDQIKMQSELVEDIIGYKPKSAENTEFIYNNDIGCFLKEMGFDVVVTEGVDYILNGRSPNKIYKNPLCNNKVVLRNYRLSDDIGFRFSNRNWEEYPLTADKYAYWINVTPGDFLLIAIDYETFGEHHNPSTGIYEFLDYLPKEILKFKNLRFSNINEAGPPGDYYDVPPFKTISWADERDLSAWLGNPLQKDAFNTLRKLYYYARYLGKDILESYRKLTISDHLYYMATKYGSMNEVHTYFNPMGGYEKAFHSFIIATTILSQKLRQKINENMCEFLRNFELPDDLCFYFNYRGNISKACSIEQLLRKIKEFPKDYLDSINEYVNQWLSQLFMIKDINEISKRCPDLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAH9</accession>
    <name>L0AAH9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231995.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0320"/>
    <dbReference type="EnsemblBacteria" id="AFZ70097">
        <property type="protein sequence ID" value="AFZ70097"/>
        <property type="gene ID" value="Calag_0320"/>
    </dbReference>
    <dbReference type="GeneID" id="14211580"/>
    <dbReference type="KEGG" id="clg:Calag_0320"/>
    <dbReference type="eggNOG" id="arCOG04293">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209471_0_0_2"/>
    <dbReference type="OMA" id="RRNIRNY"/>
    <dbReference type="OrthoDB" id="124421at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_S30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="50" mass="5591" checksum="7222B6E9A975EB88" modified="2013-03-06" version="1">MPTHGSMTKAGKVRKATPKIEPKGKKNLSPRVKNRKEFTKRIEKASKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAI0</accession>
    <name>L0AAI0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">V-type ATP synthase alpha chain</fullName>
            <ecNumber evidence="4 13">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">V-ATPase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpA</name>
        <name evidence="15" type="ordered locus">Calag_1204</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="4 13"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232820.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1204"/>
    <dbReference type="EnsemblBacteria" id="AFZ70923">
        <property type="protein sequence ID" value="AFZ70923"/>
        <property type="gene ID" value="Calag_1204"/>
    </dbReference>
    <dbReference type="GeneID" id="14212464"/>
    <dbReference type="KEGG" id="clg:Calag_1204"/>
    <dbReference type="eggNOG" id="arCOG00868">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008162_3_1_2"/>
    <dbReference type="OMA" id="RIVKTFW"/>
    <dbReference type="OrthoDB" id="6736at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="14">
        <location>
            <begin position="232"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="240"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ70923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="601" mass="67238" checksum="B7B4912895EB3AEC" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAJ7</accession>
    <name>L0AAJ7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232803.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1186"/>
    <dbReference type="EnsemblBacteria" id="AFZ70906">
        <property type="protein sequence ID" value="AFZ70906"/>
        <property type="gene ID" value="Calag_1186"/>
    </dbReference>
    <dbReference type="GeneID" id="14212446"/>
    <dbReference type="KEGG" id="clg:Calag_1186"/>
    <dbReference type="eggNOG" id="arCOG04458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1472020_0_0_2"/>
    <dbReference type="OMA" id="WCVERST"/>
    <dbReference type="OrthoDB" id="136837at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007386">
        <property type="entry name" value="DUF447"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04289">
        <property type="entry name" value="DUF447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="183" mass="21904" checksum="06648880F16CBBB9" modified="2013-03-06" version="1">MLKNIYYEFIAFTCNTRYSMPIGILFKDKPKFYVYKTTRLSKILNDKSLIYLLSPNDPLIYLKSLDHEIENEIKYVNGCPDLDNMGSVYLCYSRFLREDENGIEFECEKFEKIKGENLPYTRVYGCLVEMLILLTKIEANVIEDWFLDYAKGLKWCVERASKMDEKYVRISNEIFKRIERHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAN5</accession>
    <name>L0AAN5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1262"/>
    <dbReference type="EnsemblBacteria" id="AFZ70978">
        <property type="protein sequence ID" value="AFZ70978"/>
        <property type="gene ID" value="Calag_1262"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1262"/>
    <dbReference type="eggNOG" id="arCOG01252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_2"/>
    <dbReference type="OMA" id="HGIGYYP"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="1">
        <location>
            <begin position="44"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="513" mass="57185" checksum="5CABF86C6490F743" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAQ8</accession>
    <name>L0AAQ8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232868.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1255"/>
    <dbReference type="EnsemblBacteria" id="AFZ70971">
        <property type="protein sequence ID" value="AFZ70971"/>
        <property type="gene ID" value="Calag_1255"/>
    </dbReference>
    <dbReference type="GeneID" id="14212515"/>
    <dbReference type="KEGG" id="clg:Calag_1255"/>
    <dbReference type="eggNOG" id="arCOG01282">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_2"/>
    <dbReference type="OMA" id="ICPSIAI"/>
    <dbReference type="OrthoDB" id="22486at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="273"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="396" mass="42935" checksum="A5D7FD62B6250022" modified="2013-03-06" version="1">MPKIKGNIYIVDGLRTPVGRFGGSLKDIHPTDLASYTLKSLINRVGISPKDLDMLVYGHVIRAGTGMDTARQVALKAGVPEYIDSMTVDMVCASGMNAIITAANYIQAGSYNLIAAGGMESMSYAPFILKQNIRWGVKHLIGNEMKVLDAMVYDGLWDVFQNKIMGEEADMTAKEYNADRDSLDKISYESHMRAAKAWDSGLMKDFVIPFEQNGKTLLEQDEGIRRDTSIEKLKMLKPAFSGGYHTAGSSSQISDGAASLLIASEDKVKELGLKPLAKIVGFSFHGVETWKFPAAPVGAITKLLDSIKWNINDVDYFENNEAFAVNSFILHKELGIPYEKLNVHGGAIAIGHPLGMSGARITLELINVLKKHGGKRGIASICHGLGGASAIAIELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAR4</accession>
    <name>L0AAR4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232008.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0333"/>
    <dbReference type="EnsemblBacteria" id="AFZ70110">
        <property type="protein sequence ID" value="AFZ70110"/>
        <property type="gene ID" value="Calag_0333"/>
    </dbReference>
    <dbReference type="GeneID" id="14211593"/>
    <dbReference type="KEGG" id="clg:Calag_0333"/>
    <dbReference type="eggNOG" id="arCOG11635">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014113_0_0_2"/>
    <dbReference type="OMA" id="SREFETW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="274" mass="31324" checksum="7AD7EA959D8C2629" modified="2013-03-06" version="1" precursor="true">MRLTKLLNYKGFKLILSVILGLITFAVGISLAIALKRPLYLSIIPALMVGILTYVSSDAASKELMNYVNNLYQKVNELSDDMDFDTTQNEEETVSNDEEDLFIVYNLIKGIVKQISKEAKDIIIEIYKGDFALVYPEVSLFDDETDIDNEISYDYPEDGSDAKYHNGKLIIRMRYEDFYNLLSSLKKGDGEVAVFSTINELRTLYNITKIITIALLDEDSNELTSYITYKAIMSLKEKGILNIYDNIIEELPFESKDLKKKIKEQVKEESGTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAS0</accession>
    <name>L0AAS0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232878.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1265"/>
    <dbReference type="EnsemblBacteria" id="AFZ70981">
        <property type="protein sequence ID" value="AFZ70981"/>
        <property type="gene ID" value="Calag_1265"/>
    </dbReference>
    <dbReference type="GeneID" id="14212525"/>
    <dbReference type="KEGG" id="clg:Calag_1265"/>
    <dbReference type="eggNOG" id="arCOG00991">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1665396_0_0_2"/>
    <dbReference type="OMA" id="DYQFGRG"/>
    <dbReference type="OrthoDB" id="104837at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029402">
        <property type="entry name" value="TGT_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038250">
        <property type="entry name" value="TGT_C2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14810">
        <property type="entry name" value="TGT_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TGT_C2" evidence="3">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="2">
        <location>
            <begin position="95"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="158" mass="18048" checksum="B72A210B32C70AFA" modified="2013-03-06" version="1">MKIIEPDEDQIRIIRSILSYQFDERVAEAFIKLPLKISMRLGKIRYVYLNGNRIMTLRPTDFGFTLSIEAGKIILENSDYPKYRVVVRDDVEYMGDVMGIDVIDSDQSIKPGDEVVIISNKGEIIGIGKAKVPGFMMKSMGKGEVVRFRKVLRNEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAS4</accession>
    <name>L0AAS4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232120.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0455"/>
    <dbReference type="EnsemblBacteria" id="AFZ70222">
        <property type="protein sequence ID" value="AFZ70222"/>
        <property type="gene ID" value="Calag_0455"/>
    </dbReference>
    <dbReference type="GeneID" id="14211715"/>
    <dbReference type="KEGG" id="clg:Calag_0455"/>
    <dbReference type="eggNOG" id="arCOG11615">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2678651_0_0_2"/>
    <dbReference type="OMA" id="NICNIIR"/>
    <dbReference type="OrthoDB" id="142879at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="76" mass="8628" checksum="116746A42EDEAC8F" modified="2013-03-06" version="1">MTMKARITKRGSLAFIETEAGQKAVVPWDNICNIIRRFELIPEIVGNEKLDCVNNFNKEGEVDIDVESEGNDEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAT6</accession>
    <name>L0AAT6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-dependent phosphoesterase, PHP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0793"/>
    <dbReference type="EnsemblBacteria" id="AFZ70534">
        <property type="protein sequence ID" value="AFZ70534"/>
        <property type="gene ID" value="Calag_0793"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0793"/>
    <dbReference type="eggNOG" id="arCOG00302">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072983_1_0_2"/>
    <dbReference type="OMA" id="PWHISFR"/>
    <dbReference type="OrthoDB" id="85871at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="232" mass="25883" checksum="1495DE2930FCB535" modified="2013-03-06" version="1">MLKTLPCLAELHSHSLVSDGKSTPEEIILRAVYLGLSAIAVSDHNTFRGSAIAIESAKKLDLNITVIPANEVRTIKGDVLVLCEKIPYEEPPREPPLLHDWASINNCITIAAHPFHVGRKSIGGYLKKYPNYFDAIEVWNPRGIPFLNKPAMKLAEKFSKPKTSGSDAHIIQELGTSPTRLDTTDCDVYNIINSIRKGKCSPTINYMKISTIFNVLKWSINRRIKKNNSALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAV9</accession>
    <name>L0AAV9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70554">
        <property type="protein sequence ID" value="AFZ70554"/>
        <property type="gene ID" value="Calag_0813"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0813"/>
    <dbReference type="HOGENOM" id="CLU_3002950_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="56" mass="6042" checksum="1DD2BC08211A2620" modified="2013-03-06" version="1" precursor="true">MSIRGFKRYGMKILSVMPAIIAIISLVLGLHLGHPATTQAHLQAINPVTGDDDIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAZ1</accession>
    <name>L0AAZ1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein Calag_0537</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232195.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0537"/>
    <dbReference type="EnsemblBacteria" id="AFZ70297">
        <property type="protein sequence ID" value="AFZ70297"/>
        <property type="gene ID" value="Calag_0537"/>
    </dbReference>
    <dbReference type="GeneID" id="14211797"/>
    <dbReference type="KEGG" id="clg:Calag_0537"/>
    <dbReference type="eggNOG" id="arCOG01336">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095686_1_1_2"/>
    <dbReference type="OMA" id="RGCIGFP"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00645">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027623">
        <property type="entry name" value="AmmeMemoSam_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023472">
        <property type="entry name" value="Uncharacterised_MJ0810"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="PTHR13016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="SSF143447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04335">
        <property type="entry name" value="AmmeMemoSam_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00296">
        <property type="entry name" value="TIGR00296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="226" mass="26223" checksum="EC692A9530EE6BB2" modified="2013-03-06" version="1">MSYDLKKPVDPDEINDELGKLLVNISRQSVEYYFKNKKVMELPKDLPEILYRPGAAFTTIETYYSKEQHSLRGCIGFIEPIKPLIKTVIDVSIEAAFNDPRFEPMNPEELDTVTFEVSVLSKLEEAPKDKEGRINFIVIGRDGLVVERGYYRGLLLPQVPVENLWDKETFLSETCLKAGLWPDCWLDPKTKVYRYRAMAWKEVEPKGNIVRRDLALEYESLINKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAZ7</accession>
    <name>L0AAZ7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal protein L11 methyltransferase (PrmA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232948.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1342"/>
    <dbReference type="EnsemblBacteria" id="AFZ71051">
        <property type="protein sequence ID" value="AFZ71051"/>
        <property type="gene ID" value="Calag_1342"/>
    </dbReference>
    <dbReference type="GeneID" id="14212602"/>
    <dbReference type="KEGG" id="clg:Calag_1342"/>
    <dbReference type="eggNOG" id="arCOG00109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1323953_0_0_2"/>
    <dbReference type="OMA" id="RWADITT"/>
    <dbReference type="OrthoDB" id="72076at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="201" mass="23186" checksum="4FDD24196A4F86DD" modified="2013-03-06" version="1">MKERYINISTELGDIKIIDNKHVYKPSDDTLLIIKAMLYLKNKGYVFERIIDIGTGSGILSIAAQKIFNPKVLISIDISPYAVMAAKKVIEMENKGNSIVIRCDGTFCLRGLYDLSIVNPPYLPSNDKIDDEWIVKSWQEENNHEKVCLSSLKSKNILILKSSLSKFDQDKCLKNFNYNKQTILKENLFMEQLEVNFWQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB03</accession>
    <name>L0AB03_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S3Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosomal protein S1e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps3ae</name>
        <name evidence="4" type="ordered locus">Calag_0448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232113.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0448"/>
    <dbReference type="EnsemblBacteria" id="AFZ70215">
        <property type="protein sequence ID" value="AFZ70215"/>
        <property type="gene ID" value="Calag_0448"/>
    </dbReference>
    <dbReference type="GeneID" id="14211708"/>
    <dbReference type="KEGG" id="clg:Calag_0448"/>
    <dbReference type="eggNOG" id="arCOG04186">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062507_1_0_2"/>
    <dbReference type="OMA" id="GQNAYTK"/>
    <dbReference type="OrthoDB" id="96138at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00359">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030838">
        <property type="entry name" value="30S_S3Ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_S3Ae"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="211" mass="24023" checksum="F3996D8C6E251411" modified="2013-03-06" version="1">MPRQKSKTSVRDAWKLKKWYNIISPETFGKIQIGLTPADSEEKLSKRTVEITLFDITGNYSHVNTKLKFQINSVSEDNAYTIFKGHELLRDYLRSLTRRRSSKIAIILNVTTKDGAKIRVTSAVFTQYRCKTSQKQTIRKIMKDIIESKGNQLTFDEFVRLAVFGEQDGSLAQEITKAAKKVCNVRKVEIIKQKVIELPKNVASSHEAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB27</accession>
    <name>L0AB27_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0869"/>
    <dbReference type="EnsemblBacteria" id="AFZ70609">
        <property type="protein sequence ID" value="AFZ70609"/>
        <property type="gene ID" value="Calag_0869"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0869"/>
    <dbReference type="eggNOG" id="arCOG01393">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_822838_0_0_2"/>
    <dbReference type="OMA" id="KMNKSMQ"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="337" mass="39086" checksum="33402673EF1944D5" modified="2013-03-06" version="1">MVEMKILYASSSVGLGHITRDYHIKKRLNGEVIWLTAGNALKYIKEKGENFEEVSNKLLSLGDYIEKMIKNCKVRISISNSYQLYKAVKHNSELIKKEINFNDYDLIIADEFWEFMFINIPKERSVFLTDFTKVTMNNSYIEKLIIPRLNSGLISRINEKFALKINLSLWDKDDNFINLGPVFTDNYLENDYKENDNILINVGGTNAALKIAEKIKDKLNDKYDVKIIGSSKYFNPDPKKTIKEAGILISLSGYGSIIESNLFKKRTIFLYIENHFEHIENANIIKGRKGFRVYPCNEILNINIKNEIEKLKKEEVDSLKLNDSTNMVVEEIEKLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB39</accession>
    <name>L0AB39_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0219 protein Calag_0499</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. UPF0219 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232163.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0499"/>
    <dbReference type="EnsemblBacteria" id="AFZ70265">
        <property type="protein sequence ID" value="AFZ70265"/>
        <property type="gene ID" value="Calag_0499"/>
    </dbReference>
    <dbReference type="GeneID" id="14211759"/>
    <dbReference type="KEGG" id="clg:Calag_0499"/>
    <dbReference type="eggNOG" id="arCOG01767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_7_0_2"/>
    <dbReference type="OMA" id="YAKHKGK"/>
    <dbReference type="OrthoDB" id="12601at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01409">
        <property type="entry name" value="UPF0219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004656">
        <property type="entry name" value="FabH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00748">
        <property type="entry name" value="HMG_CoA_syn_Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="222"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="351" mass="37973" checksum="FC987D2326657304" modified="2013-03-06" version="1">MATPKAGIHGWGVYIPLYRLPLSDIAKVWGWHPDQYKGLAVEEKAIASSDEDSLTMGYEAAYNAIQRAKIEPKKISAIFFGTESKPYAVKPSATIIGEALGITPYTMASDLEFACRAASEGMRSLIGMTASGLIDFGLAIGSDTAQANPGDVLEFTAASGAAAFVIGRTNNASAIIEDSVTFVTDTPDFWRRASQPYPLHGEGFTGEPAYFYHIENAVKALLEKTGLRPSDFDYAIFHQPNGKFPVKVGQDLGFNMDQMKDGLVTPMIGNTYNASALMGLARVLDKAKAGQKILLAPFGSGAGSDAYLITVTDEVENRKYLAPMVDDYLNRKVLINYATYAKSRSIIHVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB53</accession>
    <name>L0AB53_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein translocase subunit SecE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein transport protein Sec61 gamma subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">secE</name>
        <name evidence="9" type="ordered locus">Calag_0516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232178.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0516"/>
    <dbReference type="EnsemblBacteria" id="AFZ70280">
        <property type="protein sequence ID" value="AFZ70280"/>
        <property type="gene ID" value="Calag_0516"/>
    </dbReference>
    <dbReference type="GeneID" id="14211776"/>
    <dbReference type="KEGG" id="clg:Calag_0516"/>
    <dbReference type="eggNOG" id="arCOG02204">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191921_1_0_2"/>
    <dbReference type="OMA" id="KEYLSAW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="SSF103456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="59" mass="6800" checksum="DA1B718745694C53" modified="2013-03-06" version="1">MAALEKIKEYLSAWKRIILLSRRPDEEEFNLLTRLSLLGFVIVGAIGYIIHLIYVLLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB66</accession>
    <name>L0AB66_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prefoldin subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">GimC subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pfdB</name>
        <name evidence="9" type="ordered locus">Calag_1426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233030.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1426"/>
    <dbReference type="EnsemblBacteria" id="AFZ71133">
        <property type="protein sequence ID" value="AFZ71133"/>
        <property type="gene ID" value="Calag_1426"/>
    </dbReference>
    <dbReference type="GeneID" id="14212686"/>
    <dbReference type="KEGG" id="clg:Calag_1426"/>
    <dbReference type="eggNOG" id="arCOG01342">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131909_2_0_2"/>
    <dbReference type="OMA" id="PPQVQAM"/>
    <dbReference type="OrthoDB" id="12733at183924"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00307">
        <property type="entry name" value="PfdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012713">
        <property type="entry name" value="PfdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02338">
        <property type="entry name" value="gimC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ71133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="129" mass="14551" checksum="7B4DD399C98E6467" modified="2013-03-06" version="1">MVERVPPEAEAKYNKYLQLRDSYNVVVQERINAESSLGEIEKVLEKLQSLGPDAELYKMTGFVLVKSRKEDLQKELETRKEDLELKIKALKNQETMIKEQIDKITIELRQLLSGIGGTQTKTGIGGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB77</accession>
    <name>L0AB77_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232203.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0545"/>
    <dbReference type="EnsemblBacteria" id="AFZ70305">
        <property type="protein sequence ID" value="AFZ70305"/>
        <property type="gene ID" value="Calag_0545"/>
    </dbReference>
    <dbReference type="GeneID" id="14211805"/>
    <dbReference type="KEGG" id="clg:Calag_0545"/>
    <dbReference type="eggNOG" id="arCOG04170">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032279_1_1_2"/>
    <dbReference type="OMA" id="GKAAWRM"/>
    <dbReference type="OrthoDB" id="53827at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="PTHR12227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF4147" evidence="2">
        <location>
            <begin position="29"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="1">
        <location>
            <begin position="315"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="430" mass="46455" checksum="978A0BA0AD4E7834" modified="2013-03-06" version="1">MTNPKDDLKGLINEILVKSDLSIHVKEYLKNININNVIIISFGKGSTSMSDGALEILDNKIEGGVVVIPKGSKRPKGNFEVIESSHPIPDENSIKAADSIMEWIKTSDEKTNFLFLISGGGSSLVEKPLNKISLDDIKVLNKLLLDSGASISEINTVRKHVSQIKGGRLASYIYPKKAYGLYASDVPGDVLDQIASGPTVPDPTTFNDAFNVILNYGLNDKIPKSVLDVLSEGIKGNIRETPKPGDKVFEKIKNEIIANNELILRHVSNLLSNMGYKTIILTSRIEGESREVGYALASITLDCINKGLPISPPVAFILGGETSVTVKGNGIGGRNMELALSWGLKISENTHYKNRTAILAIATDGIDGPTDSAGALLSGEDIDYIKSLGIDIKKELKNNNSYYVLNKANLLIKTGQTGSNLNNVIIITIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB85</accession>
    <name>L0AB85_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232576.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0951"/>
    <dbReference type="EnsemblBacteria" id="AFZ70679">
        <property type="protein sequence ID" value="AFZ70679"/>
        <property type="gene ID" value="Calag_0951"/>
    </dbReference>
    <dbReference type="GeneID" id="14212211"/>
    <dbReference type="KEGG" id="clg:Calag_0951"/>
    <dbReference type="eggNOG" id="arCOG00157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_2"/>
    <dbReference type="OMA" id="FMIVVTQ"/>
    <dbReference type="OrthoDB" id="53481at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="62"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="286" mass="32301" checksum="69C9A804505684D5" modified="2013-03-06" version="1" precursor="true">MKKQAYLMVIPTLFFSGLLLVTVVWNLWLSFQNWSILVHKPKFVGLSTYQFLFSQYFFKISTTHTIVFTIGLIAIGNLLGLFIAGLLYFIPSNVQRSIYLSIFIYPLAIASSTSALIWEWLLNPTIGIDWLLKLMHLPAPYWLGTPNMSLLSMVMIEIWAYTGLAALFYLAAFMGIDKSIIEAAKLDKAGNFKILFRILIPNSMNGFIISTALLFLFSFRLFTIPFVLGGSATSPTLMTYVMYVYNLFISEYFSASAAMAIIVTIIAAAVILPFAIFGLMKWVFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB93</accession>
    <name>L0AB93_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1459</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the archaeal NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233060.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1459"/>
    <dbReference type="EnsemblBacteria" id="AFZ71163">
        <property type="protein sequence ID" value="AFZ71163"/>
        <property type="gene ID" value="Calag_1459"/>
    </dbReference>
    <dbReference type="GeneID" id="14212719"/>
    <dbReference type="KEGG" id="clg:Calag_1459"/>
    <dbReference type="eggNOG" id="arCOG00972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108783_0_0_2"/>
    <dbReference type="OMA" id="VYTGNPF"/>
    <dbReference type="OrthoDB" id="90722at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00243">
        <property type="entry name" value="NMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006418">
        <property type="entry name" value="NMN_Atrans_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="178" mass="20779" checksum="51B15C0505762432" modified="2013-03-06" version="1">MQENYDRLIFPGRFQPLHIGHIKAIEYALSISKEIIIVVGSAQESYTIKNPLTAGERIEIIKNVLLKEFGEDYCKRIYIVPIMDIEMNKVWVQYLKMLLPEFDGVVSGNSLVLNLFRDMGLKAIMQPMFNRNLCSGTNIRNEIIEGRDDWKKCVPNYLYEILDKYHFVERLRSLSKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABA2</accession>
    <name>L0ABA2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS</fullName>
            <shortName evidence="1">tRNA(Ile2)-agm2C synthetase</shortName>
            <ecNumber evidence="1">6.3.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile2) agmatidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tiaS</name>
        <name evidence="4" type="ordered locus">Calag_0571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:43608"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10626"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83545"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TiaS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.22" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232228.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0571"/>
    <dbReference type="EnsemblBacteria" id="AFZ70330">
        <property type="protein sequence ID" value="AFZ70330"/>
        <property type="gene ID" value="Calag_0571"/>
    </dbReference>
    <dbReference type="GeneID" id="14211831"/>
    <dbReference type="KEGG" id="clg:Calag_0571"/>
    <dbReference type="eggNOG" id="arCOG01115">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_675459_0_0_2"/>
    <dbReference type="OMA" id="GMCTTYL"/>
    <dbReference type="OrthoDB" id="58019at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01892">
        <property type="entry name" value="tRNA_Ile2_agm2C_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013696">
        <property type="entry name" value="DUF1743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024913">
        <property type="entry name" value="tRNA_Ile2__agm2C_synt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08489">
        <property type="entry name" value="DUF1743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUF1743" evidence="3">
        <location>
            <begin position="145"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="2">
        <location>
            <begin position="271"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="443" mass="50839" checksum="73F35F276FF8C01E" modified="2013-03-06" version="1">MNNIISISFDDIDSQYGGCTTHFTGIFFNEIKNKVKLIDYPLLIRLNPGIPWKTRGNASTALRFIYDDPKEIFEIAKNLVDEYTNPRPPLPNKKPGIVMIQGKPWENEKFKTFYKKTLSDFVLLDDAIKLLNDESNKENVFYYGGKGLIGATAAQGALGLYEPYTYELIFYRLPENWDKERCVDDNTVLKVDKSLPSCTINNYDYIKEKSSVKPNGPDPILAGFRGTCEKLLWNYEKSLCEKPHFSLLYRSNQHTSFELFKDFYPYPYRNVEIEGTVLNTKILPKGHVIITLRTKYGDFDISFYKDTGPLNKAAKLLEKGDVIKVQGSVRPYSFNNTTISAYSMEVISINYTSIKLSPRCVVCGSRMKSLGKGKGFRCEKCGFETKNVEKIEIIKDRKLLPGIYLPETGELMHLQKEKYVRLPILTNFPNVDEHDILKIYNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABA5</accession>
    <name>L0ABA5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH:ubiquinone oxidoreductase subunit 11 or 4L (Chain K)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233038.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1434"/>
    <dbReference type="EnsemblBacteria" id="AFZ71141">
        <property type="protein sequence ID" value="AFZ71141"/>
        <property type="gene ID" value="Calag_1434"/>
    </dbReference>
    <dbReference type="GeneID" id="14212694"/>
    <dbReference type="KEGG" id="clg:Calag_1434"/>
    <dbReference type="eggNOG" id="arCOG12271">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2243688_0_0_2"/>
    <dbReference type="OMA" id="ILYYRQK"/>
    <dbReference type="OrthoDB" id="143585at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="104" mass="11139" checksum="8C17895DCD8B9473" modified="2013-03-06" version="1">MIVIDQLTGLVVMITAVLIMGIGGYGVTSSRSLFRQLLSIEVIFNGLLLLILSLISFNAIMATYFGIIIISVVSAEVIVVVSILVAYMRESKSLSSEDLEEGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABB1</accession>
    <name>L0ABB1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (cytosine(72)-C(5))-methyltransferase</fullName>
            <shortName evidence="4">tRNA:m(5)C72 MTase</shortName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>cytidine(72) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:61988"/>
            <dbReference type="Rhea" id="RHEA-COMP:15996"/>
            <dbReference type="Rhea" id="RHEA-COMP:15997"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0582"/>
    <dbReference type="EnsemblBacteria" id="AFZ70340">
        <property type="protein sequence ID" value="AFZ70340"/>
        <property type="gene ID" value="Calag_0582"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0582"/>
    <dbReference type="eggNOG" id="arCOG00973">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00986">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_1_0_2"/>
    <dbReference type="OMA" id="YQGAMLY"/>
    <dbReference type="OrthoDB" id="32049at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02237">
        <property type="entry name" value="NSUN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043699">
        <property type="entry name" value="NSUN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="109"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="390" mass="44509" checksum="E3B7C0696239ABA2" modified="2013-03-06" version="1">MEKNIANKYINFNNMLSYDIGLLEELDSIFGNSCKIINLLIKPPTKFYLRVNTLKITRNEYLNILKERGIKFYKDENIDYAIYAQISGPYEIPIYDKKIYVNKYASESIYLGSNLYIPGILKADKIKKGDKVTIFNRNDIPLASGISIIDWEDIYRLKKGLAVIVEDSVYKSPKIRELPGFEEGYIYSQSLPSMWVAELADPKEGSIIIDMNAAPGGKVGNIAQKVGKNSRIIAIDRPSKTNDLTEKMKRLGYDWVEVIGGDSRYATQELNIKEKADLVLIDPPCTNLGVIPKLSDKKSLRDSIILSRYQKQFINEAFKLLKPGGILMYSTCTLTYTENEENIKYALELGFELDEINIKENVIKNDYGIRFSPENDYPGFFISKLIKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABD4</accession>
    <name>L0ABD4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232345.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0702"/>
    <dbReference type="EnsemblBacteria" id="AFZ70447">
        <property type="protein sequence ID" value="AFZ70447"/>
        <property type="gene ID" value="Calag_0702"/>
    </dbReference>
    <dbReference type="GeneID" id="14211962"/>
    <dbReference type="KEGG" id="clg:Calag_0702"/>
    <dbReference type="eggNOG" id="arCOG10984">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172987_0_0_2"/>
    <dbReference type="OMA" id="VWSSAIY"/>
    <dbReference type="OrthoDB" id="141863at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="98" mass="11407" checksum="76E4D2B78A9A9CCA" modified="2013-03-06" version="1">MTQNNKIYTKYKKLIELLNLRQLDVYRIVSKDGKIKEIARIMDPVTKKVVQVDLGTVRESLNYLEFLNKIKEGVTKEGININDRVWNSTLKLIEKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABD9</accession>
    <name>L0ABD9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233068.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1468"/>
    <dbReference type="EnsemblBacteria" id="AFZ71171">
        <property type="protein sequence ID" value="AFZ71171"/>
        <property type="gene ID" value="Calag_1468"/>
    </dbReference>
    <dbReference type="GeneID" id="14212728"/>
    <dbReference type="KEGG" id="clg:Calag_1468"/>
    <dbReference type="eggNOG" id="arCOG04253">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061722_0_0_2"/>
    <dbReference type="OMA" id="VIQQGMN"/>
    <dbReference type="OrthoDB" id="61040at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008482">
        <property type="entry name" value="DUF763"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38597">
        <property type="entry name" value="PTHR38597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05559">
        <property type="entry name" value="DUF763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="377" mass="42382" checksum="29D2188EB6248B12" modified="2013-03-06" version="1">MSANYADLPLHNGHVPQWMLKIMREFTEVITKFIIEEKGVNNFINALSDPLWFQAFNNAIGMDWDSSGSTTVLLSLIKDVSMKNDLGFLVFGGKGKQMLNIKDELNNYSKKYDLDINNIMKFSKIAAKADSSFLLDGYSLYIHTIIVPVEGKDLLVIQQGMNPNNLMARRYHVNKAALENPNSGITGIKVDNVIDATSEESRNARKLFIDLLSEGKNKFRDNLVQANNMLGRKSLDYFISNQVNKINIGKYYYPIIPSKKLLKAVDDIAKNPPSNEIELALTPNVGPRLVRALALISDVIYSVPVSHKDPVNLSLDPFSYSYTIGGKDGIPYPFDAKTAKEAIEFLRNALEEARINDNAKKLAIQRLNTFIRRLKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABE5</accession>
    <name>L0ABE5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233115.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1518"/>
    <dbReference type="EnsemblBacteria" id="AFZ71218">
        <property type="protein sequence ID" value="AFZ71218"/>
        <property type="gene ID" value="Calag_1518"/>
    </dbReference>
    <dbReference type="GeneID" id="14212779"/>
    <dbReference type="KEGG" id="clg:Calag_1518"/>
    <dbReference type="eggNOG" id="arCOG00062">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_2_2"/>
    <dbReference type="OMA" id="GNTYRES"/>
    <dbReference type="OrthoDB" id="66517at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="270" mass="31078" checksum="30CDF7295015124D" modified="2013-03-06" version="1">MDNNELKIGLTQLVSSRKKEENISKIEKFVKIAKNLGADMVVFPEIFMIHFTSDDSLEKRASEAESLDGNFVKNILKLSKQYNISITVGMYESIKNNLKVYNTTITTNDNGELLNVYRKTHLYDAFNFKESDFYEPSNNKYEVFDFKGFKIGIMVCYEVRFPEIARSLTLKGAEVIIIPSAWVKGYNKEEHWITLIKARALENTVYVATSNQIGNIYTGITSFVDPLGVILHRMNEDEGIIIGEVKKERLKEVRNILPVINQRRPNLYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABF7</accession>
    <name>L0ABF7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233088.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1489"/>
    <dbReference type="EnsemblBacteria" id="AFZ71191">
        <property type="protein sequence ID" value="AFZ71191"/>
        <property type="gene ID" value="Calag_1489"/>
    </dbReference>
    <dbReference type="GeneID" id="14212749"/>
    <dbReference type="KEGG" id="clg:Calag_1489"/>
    <dbReference type="eggNOG" id="arCOG01679">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156332_0_0_2"/>
    <dbReference type="OMA" id="ANISMHI"/>
    <dbReference type="OrthoDB" id="128521at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="119" mass="13224" checksum="309035B2E156E2FC" modified="2013-03-06" version="1">MSENIPTKEGIYERDKVLYVIGPKAIAKVSSALASDTRAKILSILQKGPADLEDLANLVNQSKANVSSQIRRLEEVDIVRSKYSPGQRGIKKIVELMVNKMVMVISPDKMQEAQEKDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABI4</accession>
    <name>L0ABI4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1560"/>
    <dbReference type="EnsemblBacteria" id="AFZ71258">
        <property type="protein sequence ID" value="AFZ71258"/>
        <property type="gene ID" value="Calag_1560"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1560"/>
    <dbReference type="eggNOG" id="arCOG01097">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095256_1_0_2"/>
    <dbReference type="OMA" id="AYAEFVH"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="1">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="188" mass="21293" checksum="DA92CFD2F4C534F6" modified="2013-03-06" version="1">MSQSDHPAMTESALESSYGGESMAHMRYLIFADIAEKEGFKNVARLFRAIAFAEQVHARNHFQRLSKLKDGKKVVADAPFGPGNTSKNLELAIMGEEFEVNEMYPTYIEMAKFQKDKEAEISFRYALEAEKIHAQLFKEAKKYVDQGKDMPIDGFIWICPVCGHTLIAKEPPNRCPICAAFGKDFLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABZ4</accession>
    <name>L0ABZ4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase, type IV secretory pathway VirB11 component like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0897"/>
    <dbReference type="EnsemblBacteria" id="AFZ70637">
        <property type="protein sequence ID" value="AFZ70637"/>
        <property type="gene ID" value="Calag_0897"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0897"/>
    <dbReference type="eggNOG" id="arCOG01817">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03146">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_913996_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="304" mass="34803" checksum="27AC581073C74B85" modified="2013-03-06" version="1">MSGFICGETASGKTTALNAIATFIKPTHKIVTIEDTAEIQLPHPNWTRELARDTGRPETSVTLFDLLRAALRQRPDYIIVGEIRGAEGAIAFQAMQCIKEGKVILGDEAKEIRELFTNYKNKYGSILSNGKEIVYLKDKIEIPGYDKGVIKKANVLAIAKMPKEKLIRITLDDGNVFDVTRNHKFITNLGEISSEQIASLYKNNEILVKRVENFENKIIKRRYKFKKGVLMLSSPIFWYLTGLVLGGKIYRKKGRFYIKEKIDESFISLLPIKKMKKSKDVYQLELYFVDWLIKNGFIEIKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC06</accession>
    <name>L0AC06_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-guanine(15) transglycosylase</fullName>
            <ecNumber evidence="1">2.4.2.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-deazaguanine tRNA-ribosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Archaeal tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tgtA</name>
        <name evidence="3" type="ordered locus">Calag_1247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7-carbaguanosine(15) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:43164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10371"/>
            <dbReference type="Rhea" id="RHEA-COMP:10372"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82850"/>
            <dbReference type="EC" id="2.4.2.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; archaeosine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeosine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.48" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1247"/>
    <dbReference type="EnsemblBacteria" id="AFZ70964">
        <property type="protein sequence ID" value="AFZ70964"/>
        <property type="gene ID" value="Calag_1247"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1247"/>
    <dbReference type="eggNOG" id="arCOG00989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030083_0_0_2"/>
    <dbReference type="OMA" id="FPCSCPV"/>
    <dbReference type="OrthoDB" id="10236at2157"/>
    <dbReference type="UniPathway" id="UPA00393"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01634">
        <property type="entry name" value="TgtA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004804">
        <property type="entry name" value="TgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00432">
        <property type="entry name" value="arcsn_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="2">
        <location>
            <begin position="15"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="495" mass="57513" checksum="9D0182607A5F5B9F" modified="2013-03-06" version="1">MLLLMFNIKDFDLAARIGILKTKSYKIETPAFFPVVDPLKQDVSVKEIEEIGFNQIITNAYLSYKRFGEKVIDEGIHKVLGFDKVIMTDSGAYQVLKYGNIDVNQETVMNFEKAIGSDIAVILDKPTGDTDYDKAEKSVEETLKNAHEAINLKDDKTIWVLPIQGGKYLDLVERSAKESSKLPFEMFAIGSPTVFLEKYQYNVIIDMIAMAKKYLPPEKPVHLFGGGHPLIFPYAIALGIDSFDSASYELYAKDDRYITDYGTEKIEDLEYFPCNCPVCSRYTPKDLIQMDVKERRRLLAIHNLYAIKKSMDRTKQAIREGRLWELLVEISRYRPEMQSTLRSITKYLKYMDRFNPRYKSYSRGLKFYGIENSWNPRIINYKTWILTKYEIKDNKTILLKPYNCKKEDNEEFHVIYYVPYLLLIPYEICGLYPTAQFHFSNPIPKEVENELVNMIRVFIIKNKSKKIDVIANKNISYSYAVGKEAERLGLTVSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC39</accession>
    <name>L0AC39_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PP-loop superfamily ATP-utilizing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0969"/>
    <dbReference type="EnsemblBacteria" id="AFZ70692">
        <property type="protein sequence ID" value="AFZ70692"/>
        <property type="gene ID" value="Calag_0969"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0969"/>
    <dbReference type="eggNOG" id="arCOG00036">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010289_1_0_2"/>
    <dbReference type="OMA" id="EPLWGMD"/>
    <dbReference type="OrthoDB" id="101215at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthami_syn_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="216" mass="24674" checksum="0249E7641FE9DEBC" modified="2013-03-06" version="1">MVRIAMFSGGKDGLRAAQIEWPVDAFLFLIYEFPEPSPHIVNLQTTIASASAIGVPIVVKRLHKGKEFIETVELLRKLNTDTLIAGDVFVEDHLKYMENLVREAGAKLREPLWSLDTLEILMKDIEDNYSFKVLGARPKNLRESVGKIINKDNINWFLELAKKDNADPLGEKGEYHTIVLKSPLHKEEFSVKDLEIKELDCCRILLTSSYFNQKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC51</accession>
    <name>L0AC51_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase and fumarate reductase iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232604.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0984"/>
    <dbReference type="EnsemblBacteria" id="AFZ70707">
        <property type="protein sequence ID" value="AFZ70707"/>
        <property type="gene ID" value="Calag_0984"/>
    </dbReference>
    <dbReference type="GeneID" id="14212244"/>
    <dbReference type="KEGG" id="clg:Calag_0984"/>
    <dbReference type="eggNOG" id="arCOG00962">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_3_2_2"/>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="OrthoDB" id="88832at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="302" mass="34194" checksum="1067EF96F295AF82" modified="2013-03-06" version="1">MALDIEAATKLPPKVVIIRVRRYNPETKRIWWQEYKVETHKGMTMLDALLEIKEKIDHTLVIRYSCRMGLCGSCGVSINGTPMLACQTQVSQVASDARNVITVEPLPNFPVVKDLMTEFSDFFNKHRSVKPYLIRKDTEEQENPKGHLKMNPEEFIDVLQFSNCIFCGLCYSSCPVVAADPEYLGPQALMYAYRFINDIRDEGHKERFAIIDTEHGCHRCHFAATCSAVCPKAVDPAGAIQGLRSKLFKYRLGLYKKKSSQPLPPPPEKGERVPLPPEATTLPGVDLKQMEKEPVIIKMPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC66</accession>
    <name>L0AC66_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232517.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0880"/>
    <dbReference type="EnsemblBacteria" id="AFZ70620">
        <property type="protein sequence ID" value="AFZ70620"/>
        <property type="gene ID" value="Calag_0880"/>
    </dbReference>
    <dbReference type="GeneID" id="14212140"/>
    <dbReference type="KEGG" id="clg:Calag_0880"/>
    <dbReference type="eggNOG" id="arCOG01357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032214_0_0_2"/>
    <dbReference type="OMA" id="FFRYGAK"/>
    <dbReference type="OrthoDB" id="5945at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="217"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="528" mass="58939" checksum="1D2E0CD30DFCAAB1" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACC9</accession>
    <name>L0ACC9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0972"/>
    <dbReference type="EnsemblBacteria" id="AFZ70695">
        <property type="protein sequence ID" value="AFZ70695"/>
        <property type="gene ID" value="Calag_0972"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0972"/>
    <dbReference type="HOGENOM" id="CLU_3147785_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="48" mass="5793" checksum="50EC23CD3D55E419" modified="2013-03-06" version="1">MESLNDYFIDLDILSHRSIKRLVIFSLFVIIILIFETHNFVYVFSQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACD1</accession>
    <name>L0ACD1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232689.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1070"/>
    <dbReference type="EnsemblBacteria" id="AFZ70792">
        <property type="protein sequence ID" value="AFZ70792"/>
        <property type="gene ID" value="Calag_1070"/>
    </dbReference>
    <dbReference type="GeneID" id="14212330"/>
    <dbReference type="KEGG" id="clg:Calag_1070"/>
    <dbReference type="eggNOG" id="arCOG00751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_2"/>
    <dbReference type="OMA" id="TFVVIQF"/>
    <dbReference type="OrthoDB" id="61149at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="126"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="352" mass="38462" checksum="DE7618EAE33FF1B5" modified="2013-03-06" version="1">MGYKAYLVKEIIIYITVLIAAMSILYLFTYPIIQKSLLATVNTDVAAFRSSFLKKSAGHAVNITQVNLLADKYKQSLLSAYGLNQPIFIKYAIQMKNLLLFRFGNAYFLSAPSGSIKVADIIAAYLPYTILLFTTGTIIVIVIGTILGLLSARYAGTAWDKIIPTIAIIHSSLPTWWLGFLLIAALAYGIKIFPPGGIVSVPPPKEPFMYAINLLYHMALPLLAFFIVNVGGFAYVVRSLVISVTKEDFVTTAKARGLPDSRILYRHILRTASPSISTQVALAIAGSFAGGLTTEIVFNWHGVGWLTYVAILLEDVPVILGITFVLTVILLIALFIDELVKGILDPRIKAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACE9</accession>
    <name>L0ACE9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232709.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1090"/>
    <dbReference type="EnsemblBacteria" id="AFZ70812">
        <property type="protein sequence ID" value="AFZ70812"/>
        <property type="gene ID" value="Calag_1090"/>
    </dbReference>
    <dbReference type="GeneID" id="14212350"/>
    <dbReference type="KEGG" id="clg:Calag_1090"/>
    <dbReference type="eggNOG" id="arCOG01608">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002569_5_0_2"/>
    <dbReference type="OMA" id="YFEHKVQ"/>
    <dbReference type="OrthoDB" id="29908at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="4">
        <location>
            <begin position="20"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="5">
        <location>
            <begin position="265"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="393" mass="43748" checksum="2D03B331D942DDC9" modified="2013-03-06" version="1">MQELVKRAIPLSTNHAIANAVKDLDVDVISAYPITPQTTVVEKISEFIAKGELDAEYIHVESEHSALSAAISASLTGARAFTATASQGFALMHEMLHIASGLRAPVVMSVAMRSLSAPISIWNDQSDLFNARDSGWIIIFAHTAQEAYDTVIQSYKIAEDHNVLLPVMVGYDGYVMSHTIEPVITEDKEKVLKFAPKKQYPYKLDPDKPVSIGSITPPEYYYEFKYQQVKAINGSLPIIEKTDEDFGKTFGRSYGLMECYMCEDADSLIMTNASYASTLKAFLPEIRKQGLNVGLLRLRVYRPFPLQKFIEYTSDKKNLLVIDRAISYGAPYQGPLANEISGAMVRSGLKLNLISVVTGIGQRTVEFEDFLALARLAHEGRKHEETIFYGVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACG6</accession>
    <name>L0ACG6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232642.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1023"/>
    <dbReference type="EnsemblBacteria" id="AFZ70745">
        <property type="protein sequence ID" value="AFZ70745"/>
        <property type="gene ID" value="Calag_1023"/>
    </dbReference>
    <dbReference type="GeneID" id="14212283"/>
    <dbReference type="KEGG" id="clg:Calag_1023"/>
    <dbReference type="eggNOG" id="arCOG01125">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_2_1_2"/>
    <dbReference type="OMA" id="GASWYLE"/>
    <dbReference type="OrthoDB" id="36100at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="286" mass="31749" checksum="2228117F30B86F07" modified="2013-03-06" version="1">MEKLIEIANEVSRERVRGASWSAEAMAKAVYELSKTKVVSCDDINEISKIIVDANPAMGSLYNLSLILKNSCAAKKELYLAAEKFLNYISYSRELIIRHSYELFKEKIKIFTISNSSNVLSVIKENKDMIKKVLVSESHPGSEGAIFATEIKNYGIDVELYPDASISNAIEKSNLVLIGADNITIDGCLFNKVGTKNASIIAGYYGKPVIAVFEPFKINPEMKCGQEIAITRSYLIQGYGELTYRLFDSLPNNLLDGILSINGLMDPSSSNLSKLHESFISWFSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACK1</accession>
    <name>L0ACK1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232682.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1063"/>
    <dbReference type="EnsemblBacteria" id="AFZ70785">
        <property type="protein sequence ID" value="AFZ70785"/>
        <property type="gene ID" value="Calag_1063"/>
    </dbReference>
    <dbReference type="GeneID" id="14212323"/>
    <dbReference type="KEGG" id="clg:Calag_1063"/>
    <dbReference type="eggNOG" id="arCOG13705">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1870616_0_0_2"/>
    <dbReference type="OMA" id="GKNCIES"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="136" mass="16270" checksum="A4331D31D9336766" modified="2013-03-06" version="1">MSIDCNDKIVKIIESLIKKGLGKNCIESMLYFDYKISLNNKEFLNYYDIAFNCLYKIRNKEQENKDVCNNEIVKDIVLLIFKGYNEKTIKLKIYKKYSMHKSKNGEYIRLTLRDIDNYYEISKKCINYKKLSSEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACL1</accession>
    <name>L0ACL1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232692.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1073"/>
    <dbReference type="EnsemblBacteria" id="AFZ70795">
        <property type="protein sequence ID" value="AFZ70795"/>
        <property type="gene ID" value="Calag_1073"/>
    </dbReference>
    <dbReference type="GeneID" id="14212333"/>
    <dbReference type="KEGG" id="clg:Calag_1073"/>
    <dbReference type="eggNOG" id="arCOG00158">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_496634_0_0_2"/>
    <dbReference type="OMA" id="YAADFKL"/>
    <dbReference type="OrthoDB" id="21063at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="516"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="46"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="343"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="553" mass="61123" checksum="DB19C3891087B951" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACV9</accession>
    <name>L0ACV9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-archaeol synthase</fullName>
            <ecNumber evidence="6">2.7.7.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">carS</name>
        <name evidence="7" type="ordered locus">Calag_1169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:25690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="ChEBI" id="CHEBI:58838"/>
            <dbReference type="EC" id="2.7.7.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CDP-archaeol synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.67" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232787.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1169"/>
    <dbReference type="EnsemblBacteria" id="AFZ70890">
        <property type="protein sequence ID" value="AFZ70890"/>
        <property type="gene ID" value="Calag_1169"/>
    </dbReference>
    <dbReference type="GeneID" id="14212429"/>
    <dbReference type="KEGG" id="clg:Calag_1169"/>
    <dbReference type="eggNOG" id="arCOG04106">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105710_0_0_2"/>
    <dbReference type="OMA" id="GKTWRGT"/>
    <dbReference type="OrthoDB" id="124973at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043338">
        <property type="term" value="F:CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01117">
        <property type="entry name" value="CDP_archaeol_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032690">
        <property type="entry name" value="CarS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002726">
        <property type="entry name" value="CarS_archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39650">
        <property type="entry name" value="PTHR39650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01864">
        <property type="entry name" value="CarS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="170" mass="19063" checksum="B40497F032AD8CC1" modified="2013-03-06" version="1">MDLIHFGYDLLKLFIFILPAMVANGTPVIVHGLPPIDMGKKWRDGRRIFGDGKTWGGILSGIIAGLIIGSIESVIIWHNMLYDAFIASFGALIGDLIASFIKRRIGLERGAPAPLLDQLDFYVGALVFLYLFDGKIFNIYAELLFAVLIYALHRTTNYMAYKLKLKNVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACX2</accession>
    <name>L0ACX2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232889.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1278"/>
    <dbReference type="EnsemblBacteria" id="AFZ70992">
        <property type="protein sequence ID" value="AFZ70992"/>
        <property type="gene ID" value="Calag_1278"/>
    </dbReference>
    <dbReference type="GeneID" id="14212538"/>
    <dbReference type="KEGG" id="clg:Calag_1278"/>
    <dbReference type="eggNOG" id="arCOG11396">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2299203_0_0_2"/>
    <dbReference type="OMA" id="WLYESAG"/>
    <dbReference type="OrthoDB" id="126954at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="100" mass="11358" checksum="BF41672F4E322759" modified="2013-03-06" version="1">MAGIKQKIYEKAVKEALLSQMKNKIDIDEAVEWLYEDFGIKIKSSWENLRRAVLNNSEITPNDIAVFMIDQGVEVDEGAWHVLPTGGLRSNKSNNKHNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD11</accession>
    <name>L0AD11_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1315"/>
    <dbReference type="EnsemblBacteria" id="AFZ71027">
        <property type="protein sequence ID" value="AFZ71027"/>
        <property type="gene ID" value="Calag_1315"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1315"/>
    <dbReference type="HOGENOM" id="CLU_2091181_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="116" mass="13983" checksum="0106AF6ADC97DE9C" modified="2013-03-06" version="1">MVYVLIEEFLLDGNQRGIKVLTDNEAFYSIDYYEKIDFEPECIKKVSINNLELCYFNINERCKGLMVKSSDFIEIISLRYFMDKEEYNKISDKEIYTRCLELINNFKLNYKKEQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD26</accession>
    <name>L0AD26_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232852.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70955">
        <property type="protein sequence ID" value="AFZ70955"/>
        <property type="gene ID" value="Calag_1238"/>
    </dbReference>
    <dbReference type="GeneID" id="14212498"/>
    <dbReference type="KEGG" id="clg:Calag_1238"/>
    <dbReference type="HOGENOM" id="CLU_1444616_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="187" mass="21291" checksum="9E8CE505D23D6699" modified="2013-03-06" version="1" precursor="true">MNKLFKIINNSINNKKTNKSNQGKNSKGFMIIISILIIIILAGDIYGIVYFVFIKPYHIKYLVYPNNVIYLYPNGYSYVSVGPSSYNDIRIPFITFYEHIYGSYNTSGSIYVAIMSFSQFNSWASHGENISYLLHSLWFSNSNKSTINFNANPNVDYVIVFYNPSKNSSASVNINSDGIYVKYLGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD62</accession>
    <name>L0AD62_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232887.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70990">
        <property type="protein sequence ID" value="AFZ70990"/>
        <property type="gene ID" value="Calag_1274"/>
    </dbReference>
    <dbReference type="GeneID" id="14212534"/>
    <dbReference type="KEGG" id="clg:Calag_1274"/>
    <dbReference type="eggNOG" id="arCOG13711">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1943755_0_0_2"/>
    <dbReference type="OMA" id="SCALADM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="129" mass="14405" checksum="27FB2198267EA6F8" modified="2013-03-06" version="1">MSLDELAAIEMELIKYIEGLDKSEKKILDNTKNPNSNSLIMIRQWKVILQGFVGEIQKIIYDNKNGHNLVKEVEACILSDKAKTIMRNSSLNDPIYINVRPLISAISAISSIICEKKAMTVSHADGKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD96</accession>
    <name>L0AD96_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232922.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1313"/>
    <dbReference type="EnsemblBacteria" id="AFZ71025">
        <property type="protein sequence ID" value="AFZ71025"/>
        <property type="gene ID" value="Calag_1313"/>
    </dbReference>
    <dbReference type="GeneID" id="14212573"/>
    <dbReference type="KEGG" id="clg:Calag_1313"/>
    <dbReference type="eggNOG" id="arCOG13710">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1084172_0_0_2"/>
    <dbReference type="OMA" id="NITWIYM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="256" mass="28260" checksum="347FB88ACD571251" modified="2013-03-06" version="1" precursor="true">MVSRATTIMIVLFAATLISSGIGLYTYSSYSKPLTHIYPQPSLYQIMNKISYLKYQIYSPIYGYSYVELFNNITYQNGTALLYNATTNTVAEKIVYKYNQTGLTFLGVVVGNTTIPLNSTYYYTFYTSSYYFTNPFTGSSSLMPFPGIGPLYAIYYVGQLYKVDWQAISLGQAQPPNSYATVNLGFTDIPVFNKKYPGIEISISPASTSVIPSSYPVSFAATIVYINGVSISSQMTIGVSSADYLSFNLTSLNTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADA1</accession>
    <name>L0ADA1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232927.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1319"/>
    <dbReference type="EnsemblBacteria" id="AFZ71030">
        <property type="protein sequence ID" value="AFZ71030"/>
        <property type="gene ID" value="Calag_1319"/>
    </dbReference>
    <dbReference type="GeneID" id="14212579"/>
    <dbReference type="KEGG" id="clg:Calag_1319"/>
    <dbReference type="HOGENOM" id="CLU_1478840_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="182" mass="20281" checksum="B79A317BC8A740A5" modified="2013-03-06" version="1">MENNQQMKKLKLLKSSMNYFGSYETILPPILMSSGIIIGIIANILQSYQFISLSLIMAAITIAFAGSAMEITYLLILKRMEKVLLNTNQSLALSIVIIAVLMMLYFIVIGMPLVHYYESGILKKLYMSTEDKKKCIFDNPILSLITFGYGLSIYQACSGVNVIKIINNAINNLSIANTYVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADB6</accession>
    <name>L0ADB6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-phosphooligosaccharide-protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Oligosaccharyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">Calag_1336</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.21" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232942.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1336"/>
    <dbReference type="EnsemblBacteria" id="AFZ71045">
        <property type="protein sequence ID" value="AFZ71045"/>
        <property type="gene ID" value="Calag_1336"/>
    </dbReference>
    <dbReference type="GeneID" id="14212596"/>
    <dbReference type="KEGG" id="clg:Calag_1336"/>
    <dbReference type="eggNOG" id="arCOG02044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376262_0_0_2"/>
    <dbReference type="OMA" id="VAYSSWY"/>
    <dbReference type="OrthoDB" id="45041at2157"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="PTHR13872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFZ71045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="804" mass="89006" checksum="A99723C382C3ACC7" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADC0</accession>
    <name>L0ADC0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ordered locus">Calag_1399</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233004.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1399"/>
    <dbReference type="EnsemblBacteria" id="AFZ71107">
        <property type="protein sequence ID" value="AFZ71107"/>
        <property type="gene ID" value="Calag_1399"/>
    </dbReference>
    <dbReference type="GeneID" id="14212659"/>
    <dbReference type="KEGG" id="clg:Calag_1399"/>
    <dbReference type="eggNOG" id="arCOG00063">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_2"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="14061at2157"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="303"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="385"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ71107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="533" mass="59371" checksum="8F1E16D74DC652DD" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADG3</accession>
    <name>L0ADG3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA modification methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1453"/>
    <dbReference type="EnsemblBacteria" id="AFZ71157">
        <property type="protein sequence ID" value="AFZ71157"/>
        <property type="gene ID" value="Calag_1453"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1453"/>
    <dbReference type="eggNOG" id="arCOG00047">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057819_0_0_2"/>
    <dbReference type="OMA" id="FFHPGVM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0020" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="340" mass="38561" checksum="9E2E9B42E7E9BF57" modified="2013-03-06" version="1">MFALQKYYALLSGLHPTLPKAELESLIEVTNSKAKIIYNFDGVSIIEGFLDANNIVKRSGYIKEMGYLLGIYEDIDYNDIVKKLKDYGIKEAKVKGFRYKGFSHHINIPNVEISLSRELDKNGINANPRSNTIVRIIITEGIIIAGLLISIQENSYKERIRNRPFKRPGQIDQQLSRVMVNLSRLKDNYVFLDPFCGTGSLALEACSLNASLSICMDLDINMVKGSMLNMKSYDCCKSYLIVRHNVVKMPLKDESIDSLSTDPPYGRSTSTNKKGYKILTKNFLEEGLRVLKKGSYVVYAGPSYERPYIIAKDLGYEMIGTYDMFVHNSLNRQIVVVRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADI1</accession>
    <name>L0ADI1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L18Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein L20e</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein LX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl18a</name>
        <name evidence="3" type="synonym">rpl20e</name>
        <name evidence="3" type="synonym">rplX</name>
        <name evidence="5" type="ordered locus">Calag_1480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Binds 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233079.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1480"/>
    <dbReference type="EnsemblBacteria" id="AFZ71182">
        <property type="protein sequence ID" value="AFZ71182"/>
        <property type="gene ID" value="Calag_1480"/>
    </dbReference>
    <dbReference type="GeneID" id="14212740"/>
    <dbReference type="KEGG" id="clg:Calag_1480"/>
    <dbReference type="eggNOG" id="arCOG04175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177460_0_0_2"/>
    <dbReference type="OMA" id="WQKFTKE"/>
    <dbReference type="OrthoDB" id="125208at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_L18Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="50S_L18Ae/Ribosomal_L18a/L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_L18a//L18Ae/LX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18A" evidence="4">
        <location>
            <begin position="14"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="88" mass="10566" checksum="8D3CA34DAFDD97B1" modified="2013-03-06" version="1">MSNEIKVYLVKGKMMLSHDKFPIWNKFEIYVRAMKKEHAIERIYSELGSRHKLKREHIKIESIDEVPLDQVSDSYILKLLETNKMVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADK2</accession>
    <name>L0ADK2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ordered locus">Calag_1402</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233007.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1402"/>
    <dbReference type="EnsemblBacteria" id="AFZ71110">
        <property type="protein sequence ID" value="AFZ71110"/>
        <property type="gene ID" value="Calag_1402"/>
    </dbReference>
    <dbReference type="GeneID" id="14212662"/>
    <dbReference type="KEGG" id="clg:Calag_1402"/>
    <dbReference type="eggNOG" id="arCOG01348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_3_2"/>
    <dbReference type="OMA" id="VNLGHVG"/>
    <dbReference type="OrthoDB" id="104144at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="181"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="283" mass="32408" checksum="8D444DFCC8BA879D" modified="2013-03-06" version="1">MQQEKYGIVVKPNSNNAIDIALRVINILKKNKKEVLVEKESKENYNNIIKDVGEFNIDNNPPEKIIVIGGDGTLLRTVMREKTGNSIIMAIRAGKRGFLLDVEEYEIENRVYDFINNKYTLIEYPRLQSIFNGERKSCAMNDIVIFTADGSLVKLEIFYNKDRVYGVDGDGIVISTTVGSTAYSLSAGGPIVDPRLNLIILTPLNPVQLHIRPVVFPINGILDINVKEDSGEYYLNIDGQEKVYSKSRSSLRIELCDKPVKIARFRWWENYYERLFSRLLSYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADM0</accession>
    <name>L0ADM0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1423"/>
    <dbReference type="EnsemblBacteria" id="AFZ71130">
        <property type="protein sequence ID" value="AFZ71130"/>
        <property type="gene ID" value="Calag_1423"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1423"/>
    <dbReference type="eggNOG" id="arCOG04171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135994_0_0_2"/>
    <dbReference type="OMA" id="AEHASTF"/>
    <dbReference type="OrthoDB" id="112766at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007171">
        <property type="entry name" value="DUF371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023131">
        <property type="entry name" value="Mth639-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40696">
        <property type="entry name" value="PTHR40696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04027">
        <property type="entry name" value="DUF371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="149" mass="17110" checksum="2EC76C09F542AD93" modified="2013-03-06" version="1">MQEKEFISRWFTFKAYGHKNVRATHKTTIEITKDDYLTTRGDCIIGIKSEVSLNDFPKWLKEDIKKGNMILVVFCSKKNCDSLIGYGDSNLILNNETKIIFRKSNYIEPATALIKSNKAAADLDRNLIEELKNGGELIVMITTINFKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADP1</accession>
    <name>L0ADP1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 13">DNA ligase</fullName>
            <ecNumber evidence="13">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lig</name>
        <name evidence="16" type="ordered locus">Calag_1450</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="13"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233052.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1450"/>
    <dbReference type="EnsemblBacteria" id="AFZ71155">
        <property type="protein sequence ID" value="AFZ71155"/>
        <property type="gene ID" value="Calag_1450"/>
    </dbReference>
    <dbReference type="GeneID" id="14212710"/>
    <dbReference type="KEGG" id="clg:Calag_1450"/>
    <dbReference type="eggNOG" id="arCOG01347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_6_0_2"/>
    <dbReference type="OMA" id="WIKYKRD"/>
    <dbReference type="OrthoDB" id="52275at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="345"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="13">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ71155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="610" mass="69462" checksum="236E282701A9FB59" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADP6</accession>
    <name>L0ADP6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminomethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_1559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233154.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1559"/>
    <dbReference type="EnsemblBacteria" id="AFZ71257">
        <property type="protein sequence ID" value="AFZ71257"/>
        <property type="gene ID" value="Calag_1559"/>
    </dbReference>
    <dbReference type="GeneID" id="14212821"/>
    <dbReference type="KEGG" id="clg:Calag_1559"/>
    <dbReference type="eggNOG" id="arCOG00756">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_10_2_2"/>
    <dbReference type="OMA" id="MPVQYPA"/>
    <dbReference type="OrthoDB" id="25548at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="7">
        <location>
            <begin position="7"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="8">
        <location>
            <begin position="290"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ71257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="371" mass="41993" checksum="2F042FDC8D2499D8" modified="2013-03-06" version="1">MNDIQLKHIHQKLNASFGEFAGWNVPMIYTSTMEEHIAVRKSVGIFDISHMGRLKLTGKNSLDLLEKAFTKKIAKTKEGFMSGPTLALNEYARVIDDEMWYKINDNEWLAVPNAASRERMISHLNKISHENKFDVEIKDLTFDYVLLALQGPESQSIMDKLGASWTSSLKPLEFRLNEKIKDANVFLISRSGWTGEDGFEIWAAPKEAEKLYNQFLNLGVKPIGIAARDTLRIEMGFVLGGNEYGEDPLKYPCALSLRYGMGAIDWEKNGFIGEESLRSCRKEGLRWIRIGIEMKKSSARFIPRHGYKILVDDVEVGYVTSGTYSPIVERGVGMGYIDTRYFIIGEPITISDGKTRSGEAKISEFPLIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADS5</accession>
    <name>L0ADS5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase, FAD-containing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233092.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1493"/>
    <dbReference type="EnsemblBacteria" id="AFZ71195">
        <property type="protein sequence ID" value="AFZ71195"/>
        <property type="gene ID" value="Calag_1493"/>
    </dbReference>
    <dbReference type="GeneID" id="14212753"/>
    <dbReference type="KEGG" id="clg:Calag_1493"/>
    <dbReference type="eggNOG" id="arCOG01064">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030742_5_0_2"/>
    <dbReference type="OMA" id="YKPAFMY"/>
    <dbReference type="OrthoDB" id="25371at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="395" mass="44280" checksum="79B160AF370D7F4C" modified="2013-03-06" version="1" precursor="true">MAEKKKFLIVGGGSGGAILANSLTKEFDVTVINDTPNHYYWPQLLQIAFRNDYSNLYRPLSSLLLKGVNLIIDKVKKIDLQERTVTLSTNKNLNYDYIAIAPGVTIDHKSIEGNEKLVNQFGDFHSTPENASKVFNVVSNMKKGTFVVSVGDPYHRCPPSPYEGILMADEVFRLRGVRDNINLVLAVPYPRAYPAETFNEVLEPILKERGINVMTFFTADKVDVDNKKITSLEGEELSYDAAIVIPVHKGPKIEIKPEESINQDGFINADKLTNQILKYDDAFAIGDASTSANAKTGVTAHLQAKVVAKRVLGLDAKNTGRTNCPTELGFEKGTFVISDYNHPAAKVPANTINFIMKRLFADAYWDVIRHPEFWDPIFDVYFENTQPEILWKIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADU6</accession>
    <name>L0ADU6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thermopsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233117.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ71220">
        <property type="protein sequence ID" value="AFZ71220"/>
        <property type="gene ID" value="Calag_1520"/>
    </dbReference>
    <dbReference type="GeneID" id="14212781"/>
    <dbReference type="KEGG" id="clg:Calag_1520"/>
    <dbReference type="eggNOG" id="arCOG03670">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03671">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_307901_0_0_2"/>
    <dbReference type="OMA" id="IPGKHNE"/>
    <dbReference type="OrthoDB" id="20132at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007981">
        <property type="entry name" value="Peptidase_A5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05317">
        <property type="entry name" value="Thermopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="937"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="959" mass="109699" checksum="F27AF1FE0EC2D158" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADX9</accession>
    <name>L0ADX9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233157.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1562"/>
    <dbReference type="EnsemblBacteria" id="AFZ71260">
        <property type="protein sequence ID" value="AFZ71260"/>
        <property type="gene ID" value="Calag_1562"/>
    </dbReference>
    <dbReference type="GeneID" id="14212824"/>
    <dbReference type="KEGG" id="clg:Calag_1562"/>
    <dbReference type="eggNOG" id="arCOG10315">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1318483_0_0_2"/>
    <dbReference type="OMA" id="TIASCEW"/>
    <dbReference type="OrthoDB" id="84148at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="238" mass="27847" checksum="3A92ECEE301605E7" modified="2013-03-06" version="1">MINDESLVKLKEITSEYIKKAYMLDDFVNRSKNSMRWGGIGILMVLDASFTSIGVNYFNAVIPAVLRFKENFYDTNEIINFNELANYNLDKLKITWKNERSWLVAKNISRVLSQIEGKNDRERLRKWASLNDLDKFKKEDLSKIKGVGIITYQYLRIMGGIDTLMPDKIVIKVINELFKYANIDLKQDKNTINYIKQVEEIFRNINVEPVKITWMSWLIDSEAKKILSGKYNNVLNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADY3</accession>
    <name>L0ADY3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator, contains C-terminal CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233162.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1567"/>
    <dbReference type="EnsemblBacteria" id="AFZ71265">
        <property type="protein sequence ID" value="AFZ71265"/>
        <property type="gene ID" value="Calag_1567"/>
    </dbReference>
    <dbReference type="GeneID" id="14212829"/>
    <dbReference type="KEGG" id="clg:Calag_1567"/>
    <dbReference type="eggNOG" id="arCOG00600">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1067936_0_0_2"/>
    <dbReference type="OMA" id="GQAMSAK"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="11"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="73"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="137"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="260" mass="28448" checksum="E4CED6C7BA84B6C7" modified="2013-03-06" version="1">MSINESIYEIASKPLISIDINEYVSNAVKFMYERGLRRLAVKQNDQITGIFNISSLLKILLEGTDPSNLTLSMVELESPIYVGGTTPIKDAVDLMNKKEVTSILVGKANDVQGILTTHDIISVLSSTNIKKGVYGILDKDYPSVDIGKSKVIDVMREMVDKNKSGIFIFDGNEYVGIITIRDIIKIYSDLGSEGLNSNLNDIPINEGAYGSIGLSISELASIMYNKGSDVIAVFCSYDLCGGIDDLILTRNFNKIIEGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7J0</accession>
    <name>L0A7J0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein pelota homolog</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pelA</name>
        <name evidence="11" type="ordered locus">Calag_0046</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231736.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0046"/>
    <dbReference type="EnsemblBacteria" id="AFZ69838">
        <property type="protein sequence ID" value="AFZ69838"/>
        <property type="gene ID" value="Calag_0046"/>
    </dbReference>
    <dbReference type="GeneID" id="14211306"/>
    <dbReference type="KEGG" id="clg:Calag_0046"/>
    <dbReference type="eggNOG" id="arCOG01741">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023334_0_0_2"/>
    <dbReference type="OMA" id="DDLWHLK"/>
    <dbReference type="OrthoDB" id="90096at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01853">
        <property type="entry name" value="PelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023521">
        <property type="entry name" value="Pelota_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="Transl-rel_pelota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PTHR10853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="SSF159065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ69838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="353" mass="40128" checksum="4CBEEE2AFC303A52" modified="2013-03-06" version="1">MKIEVEKNKEQIKIIPESEEDLWNLMLILKKGDYIYTKVFRDVSMKNSKRKERKPIDIKLKLENAEFQPLTGKLRIFGTIEEGPEQFGVKGRHQSGYISLGQEIIIERKEWDEKTLNKLKSSGPKGKALIIALDYDEYAISLITSLGVYNLESSSFYFSGKEDPNRENEIESALNDLVNRIIGYLSKERANVLIIAGPGNLKEILYDKIKKIVNNIKIIIDNVSNGGIAGINEVLRRDTIIEVLKEFSSIKAQEIVNEFMMLAAKDKEMIAYTLNEVYNVSKLGAISKLVILDKLIYSIDDKERTMAQEIIENAEKYRADVVIATEDSLVSPTLSNLGGVIAILRYKLPKKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7J4</accession>
    <name>L0A7J4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein involved in rRNA processing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231741.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0051"/>
    <dbReference type="EnsemblBacteria" id="AFZ69843">
        <property type="protein sequence ID" value="AFZ69843"/>
        <property type="gene ID" value="Calag_0051"/>
    </dbReference>
    <dbReference type="GeneID" id="14211311"/>
    <dbReference type="KEGG" id="clg:Calag_0051"/>
    <dbReference type="eggNOG" id="arCOG02466">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2392735_0_0_2"/>
    <dbReference type="OrthoDB" id="115856at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="93" mass="10845" checksum="F8385BD361062245" modified="2013-03-06" version="1">MPVPPNKRKLEILGKPKNKVLNYIIVSIDNKNTKIKLNSNVYDSKFNLVGKIFDIIGNVEKPYAVIKPLSENINLNDIYFVEIKRFGNRHYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7P3</accession>
    <name>L0A7P3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231786.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0100"/>
    <dbReference type="EnsemblBacteria" id="AFZ69888">
        <property type="protein sequence ID" value="AFZ69888"/>
        <property type="gene ID" value="Calag_0100"/>
    </dbReference>
    <dbReference type="GeneID" id="14211360"/>
    <dbReference type="KEGG" id="clg:Calag_0100"/>
    <dbReference type="eggNOG" id="arCOG00086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_2_2"/>
    <dbReference type="OMA" id="TEHGHAM"/>
    <dbReference type="OrthoDB" id="100703at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="194" mass="22107" checksum="BC4ACAA784000E3E" modified="2013-03-06" version="1">MDLTLIIDNYDSFVYNIYQYVAELGSRPIVLRNDEIKLESIEKINPDRIIISPGPGSPLIKEDIGISDDIIREFGNKIPILGVCLGHQIIGYVFNSIIRNARKIYHGKISKINIINNDSQIFKGIPKEIYGTRYHSLVIDEVKKPLIIDAISDEDKEIMAIHHEKYPIFGVQFHPESIGTAYGKQIIKNFLEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7V4</accession>
    <name>L0A7V4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231809.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0123"/>
    <dbReference type="EnsemblBacteria" id="AFZ69911">
        <property type="protein sequence ID" value="AFZ69911"/>
        <property type="gene ID" value="Calag_0123"/>
    </dbReference>
    <dbReference type="GeneID" id="14211383"/>
    <dbReference type="KEGG" id="clg:Calag_0123"/>
    <dbReference type="eggNOG" id="arCOG04217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136010_0_0_2"/>
    <dbReference type="OMA" id="PHGKYVN"/>
    <dbReference type="OrthoDB" id="116372at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043998">
        <property type="entry name" value="Put_Metallopep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18894">
        <property type="entry name" value="PhageMetallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhageMetallopep" evidence="1">
        <location>
            <begin position="3"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="125" mass="14534" checksum="39323046C0003F8B" modified="2013-03-06" version="1">MIRYEKDEYLEKIVKCIIDSLEMNYIEKSNVYVVKSHNSKTKAIARIYSVPSAIRFALGMEPIYVIEFISEKFDRLSFEDKIKVIIHELLHIPSSFTGGLRPHGKIVNNRAVNNLFKKIDLKKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7V7</accession>
    <name>L0A7V7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase/AMP-acid ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231814.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0128"/>
    <dbReference type="EnsemblBacteria" id="AFZ69916">
        <property type="protein sequence ID" value="AFZ69916"/>
        <property type="gene ID" value="Calag_0128"/>
    </dbReference>
    <dbReference type="GeneID" id="14211388"/>
    <dbReference type="KEGG" id="clg:Calag_0128"/>
    <dbReference type="eggNOG" id="arCOG01529">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_2"/>
    <dbReference type="OMA" id="WMMGPWA"/>
    <dbReference type="OrthoDB" id="24323at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="94"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="537"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ69916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="657" mass="74178" checksum="283716DA583673ED" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A817</accession>
    <name>L0A817_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231911.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0231"/>
    <dbReference type="EnsemblBacteria" id="AFZ70013">
        <property type="protein sequence ID" value="AFZ70013"/>
        <property type="gene ID" value="Calag_0231"/>
    </dbReference>
    <dbReference type="GeneID" id="14211491"/>
    <dbReference type="KEGG" id="clg:Calag_0231"/>
    <dbReference type="eggNOG" id="arCOG13719">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1168534_0_0_2"/>
    <dbReference type="OMA" id="STKEIFY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="237" mass="26022" checksum="9217229B9FD12E4C" modified="2013-03-06" version="1">MGRGVKIAEAVVLIIIAIVALSLYVYNANYYLSPLTPNNNYLKTNPFKVQLIYNVSESVFTNSTPETGWTQIIVTLSEYNSTYDILSTSILNFGGSSNVVQALYYSTGNSIVLNSNIPFIANTTLLSNSTKEIFYNETNVIPVAFQNLTYKISQNGINYTATYGQYYDLSSGILVYRTFSLTANNALVANGSMTLQKVNYLSNSNTTLNLILYNTVLLLLAIVFAVSLIGAVLLLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8B0</accession>
    <name>L0A8B0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="10">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="10">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pheT</name>
        <name evidence="12" type="ordered locus">Calag_0296</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="10"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231974.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0296"/>
    <dbReference type="EnsemblBacteria" id="AFZ70076">
        <property type="protein sequence ID" value="AFZ70076"/>
        <property type="gene ID" value="Calag_0296"/>
    </dbReference>
    <dbReference type="GeneID" id="14211556"/>
    <dbReference type="KEGG" id="clg:Calag_0296"/>
    <dbReference type="eggNOG" id="arCOG00412">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020279_3_0_2"/>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="OrthoDB" id="55024at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00284">
        <property type="entry name" value="Phe_tRNA_synth_beta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022918">
        <property type="entry name" value="Phe_tRNA_ligase_beta2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="11">
        <location>
            <begin position="269"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="536" mass="61207" checksum="35809950631D853C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8C5</accession>
    <name>L0A8C5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="6">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_0326</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232001.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0326"/>
    <dbReference type="EnsemblBacteria" id="AFZ70103">
        <property type="protein sequence ID" value="AFZ70103"/>
        <property type="gene ID" value="Calag_0326"/>
    </dbReference>
    <dbReference type="GeneID" id="14211586"/>
    <dbReference type="KEGG" id="clg:Calag_0326"/>
    <dbReference type="eggNOG" id="arCOG01599">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_0_0_2"/>
    <dbReference type="OMA" id="CSGKTSH"/>
    <dbReference type="OrthoDB" id="43666at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="9">
        <location>
            <begin position="48"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="PFO_beta_C" evidence="10">
        <location>
            <begin position="199"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="318" mass="35067" checksum="2F734029CA185D20" modified="2013-03-06" version="1">MASEAKYKTDLWVDWCPACGNFGILLALQKALAELELPPEKVVDVSGIGCSGKTSHFLNANGVHGLHGRGIPFAEGIKIANPELTVIVNAGDGDLLGIGAGHFVAFGRRNLDIKVFLHDNQVYGLTKGQASPTLRKGEKVKAMPIPNMQDWVNPISIALASGFTFVARGYALWIDDLKELMKAAIKHKGAALLDILQPCPTYNNLYTPDTYKDKLYKLEADKSWDPIVKEGTKEEIEEKLSKAYIKSQEWGDKIPVGIFYVNPYVETYTDTISKLNPLYATIPPAKQSIAKDDGTPIIGIDDFRKAFDNYIIKVKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8D1</accession>
    <name>L0A8D1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative redox protein, regulator of disulfide bond formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0307"/>
    <dbReference type="EnsemblBacteria" id="AFZ70086">
        <property type="protein sequence ID" value="AFZ70086"/>
        <property type="gene ID" value="Calag_0307"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0307"/>
    <dbReference type="eggNOG" id="arCOG03686">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1691460_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="155" mass="17281" checksum="EE22FD973F5284E6" modified="2013-03-06" version="1">MLNTYKLVYLLNEKVENLSELPPLPPAKILSKSSEGMIVFISNPEFSIKVGERNDKDRGFPTPLEVFVSSLAACETITFKAIAKNMLNVIPEVSTEIDGNFEWGKGLRSVNILMKVKGLKEEDANIIFEMTKNTCPVYVTVKNSGAEIKEKLIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8E8</accession>
    <name>L0A8E8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232026.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0352"/>
    <dbReference type="EnsemblBacteria" id="AFZ70128">
        <property type="protein sequence ID" value="AFZ70128"/>
        <property type="gene ID" value="Calag_0352"/>
    </dbReference>
    <dbReference type="GeneID" id="14211612"/>
    <dbReference type="KEGG" id="clg:Calag_0352"/>
    <dbReference type="eggNOG" id="arCOG00002">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_1_3_2"/>
    <dbReference type="OMA" id="MGPPPWA"/>
    <dbReference type="OrthoDB" id="121662at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="28"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="154" mass="18279" checksum="4248AD88E1EDDE5C" modified="2013-03-06" version="1">MSFWEWRRRSQPRWAKAWRHRGWLRPMIISLLYKKPLNGVELMNEIELLTNGIWRPSPGSLYPIINELISEGLVFKNQYGKYELTNEGKEFAKATLTAFYLSPDPNYIIDRITDLLNFLESLEKENREIIKSNKDKLISIKNKIENILRYTDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8F1</accession>
    <name>L0A8F1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232031.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0357"/>
    <dbReference type="EnsemblBacteria" id="AFZ70133">
        <property type="protein sequence ID" value="AFZ70133"/>
        <property type="gene ID" value="Calag_0357"/>
    </dbReference>
    <dbReference type="GeneID" id="14211617"/>
    <dbReference type="KEGG" id="clg:Calag_0357"/>
    <dbReference type="eggNOG" id="arCOG04394">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127515_4_2_2"/>
    <dbReference type="OrthoDB" id="115872at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="118" mass="13249" checksum="C878DE2F4ADC5336" modified="2013-03-06" version="1">MKEVKAVFHINEDSQETLKNLFSSIYNLIDSLKGSEIKVEVIITDRGIINFMKGNMDKYTYETINELLGSGVKFNVCNISLRSLGIPYNDLVEGLNLVESGIVKIIDLVNSGYVYIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8J4</accession>
    <name>L0A8J4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Adenylate kinase</fullName>
            <shortName evidence="8">AK</shortName>
            <ecNumber evidence="3 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">adkA</name>
        <name evidence="9" type="ordered locus">Calag_0372</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the archaeal adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="3 8"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232044.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0372"/>
    <dbReference type="EnsemblBacteria" id="AFZ70146">
        <property type="protein sequence ID" value="AFZ70146"/>
        <property type="gene ID" value="Calag_0372"/>
    </dbReference>
    <dbReference type="GeneID" id="14211632"/>
    <dbReference type="KEGG" id="clg:Calag_0372"/>
    <dbReference type="eggNOG" id="arCOG01039">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119371_0_0_2"/>
    <dbReference type="OMA" id="HRDEMRK"/>
    <dbReference type="OrthoDB" id="79684at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00234">
        <property type="entry name" value="Adenylate_kinase_AdkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023477">
        <property type="entry name" value="Adenylate_kinase_AdkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="15"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="205" mass="23128" checksum="83B355DAADECDC35" modified="2013-03-06" version="1">MSQLRNKFKVIIVTGVPGVGKTTVLSVLQEKAKASNIKLKVLNFGTFMLETALKEKLVNNRDELRHLTLRKQLDLQQLAAKRIIEETLKDLDENGYLIIDTHAIVKTSSGYLPGLPKHVLDELKPDMITVIEADAKEIFNRQVKDSSRNRSDFGTEKDIEKLMEYARMASFSSAVHYASTVAIITNKENKANEAAEELLQFIQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8N4</accession>
    <name>L0A8N4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0428"/>
    <dbReference type="EnsemblBacteria" id="AFZ70196">
        <property type="protein sequence ID" value="AFZ70196"/>
        <property type="gene ID" value="Calag_0428"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0428"/>
    <dbReference type="eggNOG" id="arCOG00480">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043611_0_1_2"/>
    <dbReference type="OMA" id="HLAVNTF"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="299" mass="33794" checksum="022748ED60BCDD11" modified="2013-03-06" version="1">MIKMISSKLVKVLKGIRPWSLPMTIFDYIAVVLVTYIIYLKINLTLIVLGIIGSIFLHIASNIFNDYFDFKKNIDKEGNVRPYHLIIDKILSPNITLIFGFISSAIAIFIGLFLTFNGRPLSIILGLLGFLLAYGYSGFPFYLKYNALGEITAYLAWGIVVPLGAYYLATDKISFVPLIVGLPTSVYLFTVMNINNIRDINYDKNSGAKTIAIILGKYKAKMLFFFELFMPYLFVMMGIFVFKVLPITTLLSNITILYNYVIIRNAINDNLTKLDVNTAMQALLFGVMYTFSIGLTKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8N9</accession>
    <name>L0A8N9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exosome complex component Rrp41</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rrp41</name>
        <name evidence="8" type="ordered locus">Calag_0433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'-&gt;5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase PH family. Rrp41 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232099.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0433"/>
    <dbReference type="EnsemblBacteria" id="AFZ70201">
        <property type="protein sequence ID" value="AFZ70201"/>
        <property type="gene ID" value="Calag_0433"/>
    </dbReference>
    <dbReference type="GeneID" id="14211693"/>
    <dbReference type="KEGG" id="clg:Calag_0433"/>
    <dbReference type="eggNOG" id="arCOG01575">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_0_0_2"/>
    <dbReference type="OMA" id="KGKGQGW"/>
    <dbReference type="OrthoDB" id="57069at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11366">
        <property type="entry name" value="RNase_PH_archRRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00591">
        <property type="entry name" value="Exosome_Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011807">
        <property type="entry name" value="Rrp41"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02065">
        <property type="entry name" value="ECX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0271">Exosome</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="6">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="7">
        <location>
            <begin position="156"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="243" mass="26805" checksum="51F444107C0CD5C0" modified="2013-03-06" version="1">MIILARPQRFIDDDGKRLDGRKPDEVRPIKMQVGVLTNADGSALVEYGLTRVLAAVYGPKESQKSMLLPDRATLRVRYHMAPFSTEERKNPAPTRRELELSKVLRESLEPVVITEYFPRTSIDVFIEVLQSDGGTRTVGATAASLALADAGIPMRALVAGVAIGKVDNVLIVDLNEVEDMYGDADMPVVAAPDIGQITLYQLNGVLTKEEFHNAIDMAMKVITKIVDMEKETLRSSYMEVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8P0</accession>
    <name>L0A8P0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0472"/>
    <dbReference type="EnsemblBacteria" id="AFZ70238">
        <property type="protein sequence ID" value="AFZ70238"/>
        <property type="gene ID" value="Calag_0472"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0472"/>
    <dbReference type="eggNOG" id="arCOG04232">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_5_1_2"/>
    <dbReference type="OMA" id="IAQKEWV"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="1">
        <location>
            <begin position="49"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="573" mass="65520" checksum="EDF456A3D3AFA5E9" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8R9</accession>
    <name>L0A8R9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0018"/>
    <dbReference type="EnsemblBacteria" id="AFZ69814">
        <property type="protein sequence ID" value="AFZ69814"/>
        <property type="gene ID" value="Calag_0018"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0018"/>
    <dbReference type="eggNOG" id="arCOG05396">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140339_1_0_2"/>
    <dbReference type="OMA" id="EKDYMYV"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012861">
        <property type="entry name" value="DUF1634"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07843">
        <property type="entry name" value="DUF1634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="130" mass="14661" checksum="0DFCD88C604C176C" modified="2013-03-06" version="1">MREMVEFEDVIGWALRIGVIISAILIIFGFALLIIHNGAYPYTLNQLINPKSNINTKTIGFNSIISGIMSFNGLDLIMLGLVVLIATPVLRVFIGIIQFAREKDYLYTIITIIVFFNLMFAIFIIPHIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8S0</accession>
    <name>L0A8S0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">30S ribosomal protein S28e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps28e</name>
        <name evidence="4" type="ordered locus">Calag_0475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232139.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0475"/>
    <dbReference type="EnsemblBacteria" id="AFZ70241">
        <property type="protein sequence ID" value="AFZ70241"/>
        <property type="gene ID" value="Calag_0475"/>
    </dbReference>
    <dbReference type="GeneID" id="14211735"/>
    <dbReference type="KEGG" id="clg:Calag_0475"/>
    <dbReference type="eggNOG" id="arCOG04314">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178987_2_0_2"/>
    <dbReference type="OMA" id="MHGEASQ"/>
    <dbReference type="OrthoDB" id="121548at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_S28e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_S28e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="PTHR10769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="86" mass="9744" checksum="A01EAE991A13EFF0" modified="2013-03-06" version="1">MSEQKKEKNTSQDAQIIEELGYPAEVIQLIGRTGVAGEVTQVRVRILEGKDKGRIITRNVMGAVRVGDIIILRETEREARKLTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8U2</accession>
    <name>L0A8U2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232196.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0538"/>
    <dbReference type="EnsemblBacteria" id="AFZ70298">
        <property type="protein sequence ID" value="AFZ70298"/>
        <property type="gene ID" value="Calag_0538"/>
    </dbReference>
    <dbReference type="GeneID" id="14211798"/>
    <dbReference type="KEGG" id="clg:Calag_0538"/>
    <dbReference type="eggNOG" id="arCOG01564">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_913990_0_0_2"/>
    <dbReference type="OMA" id="MMDYALV"/>
    <dbReference type="OrthoDB" id="76962at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="299" mass="33464" checksum="EAB591E804BA76EF" modified="2013-03-06" version="1">MKGGIISILSPSEESAKQAAERLGKLQDKGDLNIYYRKQNDYILSTITPTQYPSSIINASIAASLSNKIIILLNENLDWKDGELLLISNSSGVKSIAIHNNVTLIKKLIGSFDANNIEISSDYENELRYQEPEERKEDFVYIDRIFTVKGVGAVMLGFTFMDLEVHDKLIALPSMQQVEIKNIQVLDEDQTKVGSGVRVGLALKNVKAEDLKDTYALIPEEKKVVKSLEGDLIKYPWSEIKDNSQYHFIAGGITIMGHLKLDKKAKVELNKPMPLTKRIMVVDVNSKIGKPRIVGYLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8U9</accession>
    <name>L0A8U9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232174.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0512"/>
    <dbReference type="EnsemblBacteria" id="AFZ70276">
        <property type="protein sequence ID" value="AFZ70276"/>
        <property type="gene ID" value="Calag_0512"/>
    </dbReference>
    <dbReference type="GeneID" id="14211772"/>
    <dbReference type="KEGG" id="clg:Calag_0512"/>
    <dbReference type="eggNOG" id="arCOG06088">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191134_0_0_2"/>
    <dbReference type="OMA" id="HTNGARK"/>
    <dbReference type="OrthoDB" id="125667at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="86" mass="9986" checksum="790E2759C89E175D" modified="2013-03-06" version="1">MIKEVRTEILCPRCKVPMDYLSETEKTSNNNGRSTKITRYYRCPVCGRRIIDEVLIIKDNNTDITIESHTNGARKLLEKQKTSLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8V7</accession>
    <name>L0A8V7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70286">
        <property type="protein sequence ID" value="AFZ70286"/>
        <property type="gene ID" value="Calag_0523"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0523"/>
    <dbReference type="eggNOG" id="arCOG00022">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1682595_0_0_2"/>
    <dbReference type="OMA" id="KNHIMEE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="156" mass="18667" checksum="3F266F73F7DFFA5E" modified="2013-03-06" version="1">MNMYDKEFAEKISEWKEIEENHSKSHKETMDKVKSPILRLILTVISLDSYKHSLIYEIIEDTIKENKYNILLKEESEEVLKELKNHIMEEREAIKFLTNFLNSNNDFVRFALKLIYKDELLHHVLLHDAFNALINSNDESFKELYESIDKWLKCDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8W1</accession>
    <name>L0A8W1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Geranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="9">GGGP synthase</shortName>
            <shortName evidence="9">GGGPS</shortName>
            <ecNumber evidence="9">2.5.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(S)-3-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoglycerol geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Calag_0530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23404"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GGGP/HepGP synthase family. Group II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.41" evidence="9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232189.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0530"/>
    <dbReference type="EnsemblBacteria" id="AFZ70291">
        <property type="protein sequence ID" value="AFZ70291"/>
        <property type="gene ID" value="Calag_0530"/>
    </dbReference>
    <dbReference type="GeneID" id="14211790"/>
    <dbReference type="KEGG" id="clg:Calag_0530"/>
    <dbReference type="eggNOG" id="arCOG01085">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068610_0_0_2"/>
    <dbReference type="OMA" id="ADAIFFM"/>
    <dbReference type="OrthoDB" id="94629at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047294">
        <property type="term" value="F:phosphoglycerol geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02812">
        <property type="entry name" value="PcrB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00112">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038597">
        <property type="entry name" value="GGGP/HepGP_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008205">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010946">
        <property type="entry name" value="GGGP_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01884">
        <property type="entry name" value="PcrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01769">
        <property type="entry name" value="GGGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01768">
        <property type="entry name" value="GGGP-family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="9">
        <location>
            <begin position="170"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="9">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="9">
        <location>
            <begin position="228"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="249" mass="26446" checksum="8A78F254A2EBE4CD" modified="2013-03-06" version="1">MKDKTFKRLLKNKDNKIHLTLIDPDKTNPEIAKKISLNAYEAGSDAILIGGSLGVYEPHLTELVKSCKESGLPVILFPGNINGLTSSADAVLFMLLLNSDDPYYVGGVQAQAAPIILRMGLETIPTAYIIIGHGGAAGYIGKARPIPYERGDIAAAYSLAGAMLGAKIIYLEAGSGAPYPIPPQTISLVRRALDQIEYDGLLIVGGGINSPESAKEAIKAGADGIVNGTIVEKDPLSLYHMIRAIRNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A905</accession>
    <name>L0A905_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-methylhydantoinase A/acetone carboxylase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232271.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0618"/>
    <dbReference type="EnsemblBacteria" id="AFZ70373">
        <property type="protein sequence ID" value="AFZ70373"/>
        <property type="gene ID" value="Calag_0618"/>
    </dbReference>
    <dbReference type="GeneID" id="14211878"/>
    <dbReference type="KEGG" id="clg:Calag_0618"/>
    <dbReference type="eggNOG" id="arCOG01511">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002157_1_2_2"/>
    <dbReference type="OMA" id="HAMTVSV"/>
    <dbReference type="OrthoDB" id="4114at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydant_A_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_A" evidence="1">
        <location>
            <begin position="199"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="659" mass="72400" checksum="DDCA48A284050C4A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A937</accession>
    <name>L0A937_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor synthesis domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0626"/>
    <dbReference type="EnsemblBacteria" id="AFZ70381">
        <property type="protein sequence ID" value="AFZ70381"/>
        <property type="gene ID" value="Calag_0626"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0626"/>
    <dbReference type="eggNOG" id="arCOG00214">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077358_2_3_2"/>
    <dbReference type="OMA" id="TGWDGIL"/>
    <dbReference type="OrthoDB" id="108340at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012245">
        <property type="entry name" value="MoaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43232">
        <property type="entry name" value="PTHR43232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006443">
        <property type="entry name" value="MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="8"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="162" mass="17726" checksum="E2BD04DE32F5E9D3" modified="2013-03-06" version="1">MLVLARFALIVTSDSVYNGIKKDEITPIVEKMLKEYNQELVFKTIIKNNKEDLINALNNSLNISDIILVTGGTGISPKDISIDVVKSIAQKELPGFGEIHRMKSFNDVGYRVVLSRASAFIINKNLVAVSPGNPSAVKISLEILISIANHAVEQLSGKPHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A977</accession>
    <name>L0A977_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231877.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0197"/>
    <dbReference type="EnsemblBacteria" id="AFZ69979">
        <property type="protein sequence ID" value="AFZ69979"/>
        <property type="gene ID" value="Calag_0197"/>
    </dbReference>
    <dbReference type="GeneID" id="14211457"/>
    <dbReference type="KEGG" id="clg:Calag_0197"/>
    <dbReference type="eggNOG" id="arCOG00284">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_453183_0_0_2"/>
    <dbReference type="OMA" id="NTKVAMR"/>
    <dbReference type="OrthoDB" id="13246at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033186">
        <property type="entry name" value="HerA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05872">
        <property type="entry name" value="DUF853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="174"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="528" mass="59757" checksum="492534B056AA56E9" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A997</accession>
    <name>L0A997_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232344.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70446">
        <property type="protein sequence ID" value="AFZ70446"/>
        <property type="gene ID" value="Calag_0701"/>
    </dbReference>
    <dbReference type="GeneID" id="14211961"/>
    <dbReference type="KEGG" id="clg:Calag_0701"/>
    <dbReference type="eggNOG" id="arCOG07512">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2730125_0_0_2"/>
    <dbReference type="OMA" id="GDECHAS"/>
    <dbReference type="OrthoDB" id="143107at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="71" mass="8253" checksum="A14CF11A285CCAE8" modified="2013-03-06" version="1">MRKSYLKVTVNLDLIAEELKRLNKRYITIKDFSRYFGISNKTSGKILKHLEKMGYVKRYSTSAYSIIGDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9A8</accession>
    <name>L0A9A8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoacid:ferredoxin oxidoreductase, gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231907.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0227"/>
    <dbReference type="EnsemblBacteria" id="AFZ70009">
        <property type="protein sequence ID" value="AFZ70009"/>
        <property type="gene ID" value="Calag_0227"/>
    </dbReference>
    <dbReference type="GeneID" id="14211487"/>
    <dbReference type="KEGG" id="clg:Calag_0227"/>
    <dbReference type="eggNOG" id="arCOG01602">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_1_0_2"/>
    <dbReference type="OMA" id="HGMSQRF"/>
    <dbReference type="OrthoDB" id="120779at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="15"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="192" mass="21038" checksum="D678420BAD50AF74" modified="2013-03-06" version="1">MAMNSKLNIVISGVGGQGIVTLARIIGEAAVNNDVKVLIAETHGLSQRGGSVEVHVRLGNVYAPLVPKGGADILLSMELIESARNVDYLNKDGMVISSDTILRPPIPGVKLPKKEEIIKEFEKNNIKYYLIPTKELAEKIGSYQSENMILLGALYKFSQISKFINIDSIKESIKTMRNPEINIKAFELGNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9H9</accession>
    <name>L0A9H9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase, glucoamylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231972.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0294"/>
    <dbReference type="EnsemblBacteria" id="AFZ70074">
        <property type="protein sequence ID" value="AFZ70074"/>
        <property type="gene ID" value="Calag_0294"/>
    </dbReference>
    <dbReference type="GeneID" id="14211554"/>
    <dbReference type="KEGG" id="clg:Calag_0294"/>
    <dbReference type="eggNOG" id="arCOG03285">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028187_0_0_2"/>
    <dbReference type="OMA" id="NPWIICT"/>
    <dbReference type="OrthoDB" id="5867at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="241"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="610" mass="70285" checksum="DF30D7FDAB913334" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9J7</accession>
    <name>L0A9J7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal L38e protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0011"/>
    <dbReference type="EnsemblBacteria" id="AFZ69807">
        <property type="protein sequence ID" value="AFZ69807"/>
        <property type="gene ID" value="Calag_0011"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0011"/>
    <dbReference type="eggNOG" id="arCOG04057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2009993_0_0_2"/>
    <dbReference type="OMA" id="AQKGIEC"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_L38e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_L38e_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="123" mass="14479" checksum="929F7986D8DE265F" modified="2013-03-06" version="1">MPIEVKSLEELEKIAQKGIECRVKRNNKDGMAKIKVRTNKYLYTFKVEKDKVDEILTKLNCKNVVDLDKQKPKQQKPKKKEEKKEVKEEAKEEVKGGEEKKETKEEEKTQTNIASEEKKEENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9J9</accession>
    <name>L0A9J9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator with CopG/Arc/MetJ DNA-binding domain and metal-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0805"/>
    <dbReference type="EnsemblBacteria" id="AFZ70546">
        <property type="protein sequence ID" value="AFZ70546"/>
        <property type="gene ID" value="Calag_0805"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0805"/>
    <dbReference type="eggNOG" id="arCOG01008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113319_3_0_2"/>
    <dbReference type="OMA" id="VAYTHLH"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038733">
        <property type="entry name" value="Predicted_DNA_bind_prot_RHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12651">
        <property type="entry name" value="RHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_3" evidence="1">
        <location>
            <begin position="7"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="135" mass="15577" checksum="07F0F576EB10B75B" modified="2013-03-06" version="1">MMRILSKKRFGISIPDDLYDNLNKLSKQLDTNRSDLVEQAVKTFINDYKHYLTPHNCIGVMIISCKDETAAKEAIDRFQDVAKTYIHTHENNICIELLFVSGPSEKIAELQKNLEKEGKCQPRYIPLVNVDSYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9M4</accession>
    <name>L0A9M4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-dimethylarginine dimethylaminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0835"/>
    <dbReference type="EnsemblBacteria" id="AFZ70576">
        <property type="protein sequence ID" value="AFZ70576"/>
        <property type="gene ID" value="Calag_0835"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0835"/>
    <dbReference type="eggNOG" id="arCOG03109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057463_1_0_2"/>
    <dbReference type="OMA" id="WWRRGEN"/>
    <dbReference type="OrthoDB" id="63325at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="300" mass="34056" checksum="419452F7689AF08F" modified="2013-03-06" version="1">MILEGGMRCMIYLDSEVGKLREIMMHVPGKELEIVNENNYRSYLFSSVVDPNEFKKEITDLIDLYKKEGVKINLVQDLEDKPNGVYARDPFLMTPKGAIIANFKYDVRRGEEKVYEEYLNKLNVPIVKKMQNNEIFEGGNALILRKDVALVGIGERNNKSGVESFISLLRDMGFNNIFVIQTPIARIHIDEYVSQINEDTIITIRQMFPWDVANELKNLGFNIITVEYSDISTNLKTKLCLNTVALEPNKILIGEGCDPIRKVLEENAVDVLEIKIDEIVKGGGGIHCVTGQIKRDLISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9M7</accession>
    <name>L0A9M7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM protein, BA_1875 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231745.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0055"/>
    <dbReference type="EnsemblBacteria" id="AFZ69847">
        <property type="protein sequence ID" value="AFZ69847"/>
        <property type="gene ID" value="Calag_0055"/>
    </dbReference>
    <dbReference type="GeneID" id="14211315"/>
    <dbReference type="KEGG" id="clg:Calag_0055"/>
    <dbReference type="eggNOG" id="arCOG00940">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_0_2"/>
    <dbReference type="OMA" id="GWGRQFF"/>
    <dbReference type="OrthoDB" id="18533at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="9"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ69847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="392" mass="44749" checksum="80B693D6642A35BB" modified="2013-03-06" version="1">MSHKEWPLDEKPLLIFWETTKACGLACKHCRAEAIHNPLPNELNNEEGKKLIDQISEFGKPSPILVFTGGDPLSRKDIWDLIDYANKKGVVAALSPSVTPLLNDDAIENIVNHKISSVSISLDSPYPEIHDKIRGINGTWNRSIEYIKKMVDKGIKVQINTTVMRSTVEGLPDMVSLLKKLNISVWEVFYLIPVGRAKFEEDLTKEEWEDVGAFLYEASKYGLTIRTTEGPMFRRIALLYRNLEIRNIDYNKEILHGELYYNLVRRLRENMGEPNKETKAETFRTRDGRGIVFVSYDGYIYPSGFLPYPAGNVRKQNIVDIYRNSELFKKLRSAQFKGKCGLCEFRNICGGSRARAFSYTGDPFADDPACSYNPGEYDKILGKYGLSYDDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9P8</accession>
    <name>L0A9P8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232032.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0358"/>
    <dbReference type="EnsemblBacteria" id="AFZ70134">
        <property type="protein sequence ID" value="AFZ70134"/>
        <property type="gene ID" value="Calag_0358"/>
    </dbReference>
    <dbReference type="GeneID" id="14211618"/>
    <dbReference type="KEGG" id="clg:Calag_0358"/>
    <dbReference type="eggNOG" id="arCOG01000">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_2_2"/>
    <dbReference type="OMA" id="DIYNAMW"/>
    <dbReference type="OrthoDB" id="14436at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="3">
        <location>
            <begin position="159"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="372" mass="42007" checksum="998A50429BFCEF28" modified="2013-03-06" version="1">MEGRWDKNKEKLKSLLDKYNLDVLILTGKENIIYSTGIRDPTEVLILSNKCPDYLLTSTLDYFRMLSRAPKDISLKAFYRPGEKGTEPPIPKSDLVEGGLIDAIKLISSQCGNKIAADLQWANYTIGNYLNEQLKIQDLSNDIIKIREIKDDWEVEFITNSINASEKALRDALNVLESNPSENEVEAVFYSSLMNQNAWGEAFPTIVGFYENTALPHYNPGNVRLQKPGPVLIDFGANMNGYLSDMTRSLWFGEGGKEYKKLIETVAEAQSEAIDSIKPGVEAWEPDKAARLVFDRENITRYFNHGLGHGVGVEIHEAPYLRPNSKEILEPGMIVTVEPGIYYPGLYGVRIEDMVYITKNKARLITKFSRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9U0</accession>
    <name>L0A9U0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeS assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232513.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0876"/>
    <dbReference type="EnsemblBacteria" id="AFZ70616">
        <property type="protein sequence ID" value="AFZ70616"/>
        <property type="gene ID" value="Calag_0876"/>
    </dbReference>
    <dbReference type="GeneID" id="14212136"/>
    <dbReference type="KEGG" id="clg:Calag_0876"/>
    <dbReference type="eggNOG" id="arCOG01715">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_1_2"/>
    <dbReference type="OMA" id="YYSAPKQ"/>
    <dbReference type="OrthoDB" id="19042at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="57"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="485" mass="54179" checksum="52DCB775BF0DFEF5" modified="2013-03-06" version="1">MGSPIELAKDKELKEIVENRGIEEILGKSVPYPKDIEIKGKITRDIIEEISKSKKEPQWMLNLRLKALELFEKLPMPNWIQGIESIDLEEFSQYVKPKVEVAENWDQLPDWMRDMYSRIGLPETEAKVLSGLTAVFDSENIISRLKEELKQKKVIFMPMDEAVQKYPDLVKEYFGKQFPMADHKFAALHYALWSGGAFVYVPKNTKLVNPVEAFFIIGGEMEGQFEHTLLVADDNSSVGTSYIHFIEGCAAPVLRNFSFHDGMVEIYAGKNSQVYFSTLQNWSRSIINFNNKRAVAMENAHVEWVEGSIGSKMTYTYPSTVLRGRGASTKNVSIGISNGPYIKDVGSKAIHAAPDTKSIIISKSISSNGGIAAYRGLVKVLKGAERSFAHVQCDSLILDEKSSAYTLPRNEVDEPTAIVSHEATVGRLGEDQLFYMASRGIREGEAKALIVNGFIRDVLKSLPLETVSILTRVIGMEFSEFGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9V1</accession>
    <name>L0A9V1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L37Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ribosomal protein L43e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl37ae</name>
        <name evidence="3" type="ordered locus">Calag_0431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232097.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0431"/>
    <dbReference type="EnsemblBacteria" id="AFZ70199">
        <property type="protein sequence ID" value="AFZ70199"/>
        <property type="gene ID" value="Calag_0431"/>
    </dbReference>
    <dbReference type="GeneID" id="14211691"/>
    <dbReference type="KEGG" id="clg:Calag_0431"/>
    <dbReference type="eggNOG" id="arCOG04208">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141199_2_0_2"/>
    <dbReference type="OMA" id="ISTGIWQ"/>
    <dbReference type="OrthoDB" id="122290at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_L37Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_L37ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="88" mass="10052" checksum="C61469C9288E51EB" modified="2013-03-06" version="1">MVYSHTKIVGPAGRYGPRYGSTLRKRTKAVMEKMYQDHQCPFCGSIGTVKRESVGIWICKKCGHKWAGASYTPRSELSIYLPRYFKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9W3</accession>
    <name>L0A9W3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232580.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0955"/>
    <dbReference type="EnsemblBacteria" id="AFZ70683">
        <property type="protein sequence ID" value="AFZ70683"/>
        <property type="gene ID" value="Calag_0955"/>
    </dbReference>
    <dbReference type="GeneID" id="14212215"/>
    <dbReference type="KEGG" id="clg:Calag_0955"/>
    <dbReference type="eggNOG" id="arCOG00177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OMA" id="ARVIVME"/>
    <dbReference type="OrthoDB" id="88924at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040856">
        <property type="entry name" value="GlcV_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17847">
        <property type="entry name" value="GlcV_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="4"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="362" mass="40070" checksum="9A2672B2CBC3D8BF" modified="2013-03-06" version="1">MAKVILKELTKIFKKGKALIYAANKVSLEVNDGESFGILGPSGGGKTTLLRLIAGLEVPTDGYIYFDNVMVSAPNKVIIDPADRGIAMVFQNWALYPNMTIFDNIAFPLRNQKVPKAEISKKVNEVAEILNIKNVLDHYPREVSGGQMQRAALARALVKNPKLLLLDEPFSNLDAQIRDSARALVKKIQKELKLTTIIVSHDPADIFSIAEQVGVIFNGILVQKGNASEIYDNPVNVTVSRLLGDINIIKAEINNNAINLGNIIIPINNRKIEKQVVYIGIRPEDIRISDSNEIPEFVNVGKVKVKVTSYVAGIFKAVVSPINDESIEFDVNTERHIKAGTEMNLFVRTNKIKIFDEKGNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9X9</accession>
    <name>L0A9X9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0069"/>
    <dbReference type="EnsemblBacteria" id="AFZ69860">
        <property type="protein sequence ID" value="AFZ69860"/>
        <property type="gene ID" value="Calag_0069"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0069"/>
    <dbReference type="eggNOG" id="arCOG05967">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432549_0_0_2"/>
    <dbReference type="OMA" id="WWKPLTS"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PTHR31104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="590" mass="65606" checksum="2F2F6FDAC24F913F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Z3</accession>
    <name>L0A9Z3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232615.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0995"/>
    <dbReference type="EnsemblBacteria" id="AFZ70718">
        <property type="protein sequence ID" value="AFZ70718"/>
        <property type="gene ID" value="Calag_0995"/>
    </dbReference>
    <dbReference type="GeneID" id="14212255"/>
    <dbReference type="KEGG" id="clg:Calag_0995"/>
    <dbReference type="eggNOG" id="arCOG11611">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1100907_0_0_2"/>
    <dbReference type="OMA" id="VMLYPVV"/>
    <dbReference type="OrthoDB" id="135573at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="246" mass="27103" checksum="A50B32F5200F931B" modified="2013-03-06" version="1">MSIKKSWELALIDLYDSLRPPSFDIMLILVSALSGILSVLEPVTTPPAVANAVLGAVLFVTSLYLALRASSDLVNLVQTGVMPLYLTYPISRRESSLIIYLTRVFIPSLILLGIPAIVSGVMLYPVVGRNIGEFLIMWVSYLIQAQLYGSIFILASIKTKSSGTSAVISITGYFGFTVTSIILALIGSLNNIEILTKIANSMGLYNVVYDMITKVSTPLWEIFVVPLIFLALFITYIIYFTRRFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA13</accession>
    <name>L0AA13_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231870.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0189"/>
    <dbReference type="EnsemblBacteria" id="AFZ69972">
        <property type="protein sequence ID" value="AFZ69972"/>
        <property type="gene ID" value="Calag_0189"/>
    </dbReference>
    <dbReference type="GeneID" id="14211449"/>
    <dbReference type="KEGG" id="clg:Calag_0189"/>
    <dbReference type="eggNOG" id="arCOG02441">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625011_0_0_2"/>
    <dbReference type="OMA" id="RTTIIMI"/>
    <dbReference type="OrthoDB" id="143672at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ69972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="438" mass="47760" checksum="6CBE108A94C6A96B" modified="2013-03-06" version="1" precursor="true">MSQAMIYDMKRTITKPLVIILIIGLVAAGIGVAYLEVRALSAQSSSYSVVYAMGIANNGTKIIALAINPQGNAIGNAKVLINNSWYVTNSSGYLTINQPNGTGFTFTNPTTIQINGVNYTATLSMVSLTGVNLKEKTAIIYVGTTTFPINGVNQNNITYRVYFAQESLTRFERGISSNLNYTYIGNITGFTIAKFNVKINVNEPVIFVRLEPMGTAYKLGNMTFTTTSSTLEVPDLQKTAITTASYVFAEFFPLVGLFLVNEMFASLRANGAIDFIASRPITRKQLLVSRYIGGTFALIVGSLITSLLIPITVSYLMGTSVSLNTIGKMFGMLLVDTIGFYSLLYLISSSIRKDFIPIGIVLYLILYLFNIFNIVALFTGIFDLMYVTPYGLYEVVMGGINLGFSASANNLIVSISGILWIIVPIILAIIIYDKNDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA22</accession>
    <name>L0AA22_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase, hydrophobic anchor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0983</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232603.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0983"/>
    <dbReference type="EnsemblBacteria" id="AFZ70706">
        <property type="protein sequence ID" value="AFZ70706"/>
        <property type="gene ID" value="Calag_0983"/>
    </dbReference>
    <dbReference type="GeneID" id="14212243"/>
    <dbReference type="KEGG" id="clg:Calag_0983"/>
    <dbReference type="eggNOG" id="arCOG04162">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2067768_0_0_2"/>
    <dbReference type="OMA" id="IHLAFRW"/>
    <dbReference type="OrthoDB" id="12920at183924"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="117" mass="13401" checksum="849E380149A2CFE3" modified="2013-03-06" version="1">MAGKASNIQVWQYITAILLIFLLGYHLLQRLPWLFNVSTFDQTLTSSFVYNQYQQAGWALLLLAWVALFHGLNGVRGMLFELHQGETYNKIINVLFWIVFIVFSAIAALTIIKLPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA32</accession>
    <name>L0AA32_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231808.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ69910">
        <property type="protein sequence ID" value="AFZ69910"/>
        <property type="gene ID" value="Calag_0122"/>
    </dbReference>
    <dbReference type="GeneID" id="14211382"/>
    <dbReference type="KEGG" id="clg:Calag_0122"/>
    <dbReference type="eggNOG" id="arCOG06957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_775233_0_0_2"/>
    <dbReference type="OMA" id="SGNTWGT"/>
    <dbReference type="OrthoDB" id="128877at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="338" mass="36298" checksum="303543716D299CB5" modified="2013-03-06" version="1" precursor="true">MSKYKYFYIAFICCSLILLAIPIAFSASGTSKFIINQTTFNITPGKSVSEKFQLVLSSGTTWGTDIAVSPSVSGISITFNPSSGDPTFSGSFTISVSNNAKPGKYVFNVSATGDDPTTSPTSIIVYVSSPAISTTTTTTTTSTSSTTTTTTSTPTPVTTTTTTSTTKQGNYFVYVIAVLVILAIIIGGVLYYSKSANSVKYAVSSFSILSILISLYLIFFDSTLRSFASIHYYLLIIYTIILILINPLIYGKRLNIIYPIQAIISAIFFIGMLLDSLLGMPLSSIGDAGSSFSMNYFFGFGANSVSTFPISFSFSFLLILTFLILISSIIGIFKKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA40</accession>
    <name>L0AA40_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase, class IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232187.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0528"/>
    <dbReference type="EnsemblBacteria" id="AFZ70289">
        <property type="protein sequence ID" value="AFZ70289"/>
        <property type="gene ID" value="Calag_0528"/>
    </dbReference>
    <dbReference type="GeneID" id="14211788"/>
    <dbReference type="KEGG" id="clg:Calag_0528"/>
    <dbReference type="eggNOG" id="arCOG00984">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_4_2"/>
    <dbReference type="OMA" id="CTMALNG"/>
    <dbReference type="OrthoDB" id="22099at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd08186">
        <property type="entry name" value="Fe-ADH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045910">
        <property type="entry name" value="AdhA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="12"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="385" mass="42364" checksum="655159405AEE70CA" modified="2013-03-06" version="1">MIKFKWIYNNDEINFGPSSIQELKNYLKDNMKVIIVTGKMSAKLSGALDDTIKILKENGVSYYIFDNVSPNPLSSQADELAKMIISYNPNAIIAIGGGSVIDTAKLGAATAANGGKTVDYLYGKRKVEKIIPIYAINLTHGTGSEANRYANTTDTERGDKLGNAICYPKAAFDDPKYTLSMPKEEVLCTTFDAFYHAYESSTTSNSPPLVHMLSLEVVNQIKENLPLAIQKLDDINPRYYLLYASMLAGVSIDLSPTNIIHALENIMSGLVPSLPHGCGLALIGPLLAPLIHKSSPNESTKILKILNPNIKPNSDDSLITKTLIEFHSSVGFNKKLSDYGFGRDMLRESIRRAFANPVVVDRLKNRLYGTNIDEKILINLLENSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA75</accession>
    <name>L0AA75_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA intron endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232663.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1044"/>
    <dbReference type="EnsemblBacteria" id="AFZ70766">
        <property type="protein sequence ID" value="AFZ70766"/>
        <property type="gene ID" value="Calag_1044"/>
    </dbReference>
    <dbReference type="GeneID" id="14212304"/>
    <dbReference type="KEGG" id="clg:Calag_1044"/>
    <dbReference type="eggNOG" id="arCOG01701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114393_0_0_2"/>
    <dbReference type="OMA" id="KGPGIDH"/>
    <dbReference type="OrthoDB" id="98477at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006678">
        <property type="entry name" value="tRNA_intron_Endonuc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036740">
        <property type="entry name" value="tRNA_intron_Endonuc_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016442">
        <property type="entry name" value="tRNA_splic_arch_short"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02778">
        <property type="entry name" value="tRNA_int_endo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005285">
        <property type="entry name" value="tRNA_splic_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="SSF53032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55267">
        <property type="entry name" value="SSF55267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_int_endo_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_int_endo" evidence="3">
        <location>
            <begin position="91"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="181" mass="21026" checksum="FE0A15CBE5A227E6" modified="2013-03-06" version="1">MVIRADILNGVVIIKDLNNSRKIYFLGYFGKPINAEKVKVETDITSPLILNSFEALYLMEKGVIDLFYNDKRVNDINEAKKILKINSKKERQYEIYKELRDNGLKVRSGLKYGSDFVAYRLGPGIEHAPFIIHYYDINENFDPIELVRAGRLSHSVKKDFIISSLKDNGKSLYIIFKWFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-12-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA96</accession>
    <name>L0AA96_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative redox protein, regulator of disulfide bond formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0181"/>
    <dbReference type="EnsemblBacteria" id="AFZ69965">
        <property type="protein sequence ID" value="AFZ69965"/>
        <property type="gene ID" value="Calag_0181"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0181"/>
    <dbReference type="eggNOG" id="arCOG02062">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165255_1_2_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="77" mass="8523" checksum="1617FDB6101B0792" modified="2013-03-06" version="1">MADIVVDSKGLACPGPITELIKAYKKAKNGDRIILYATDPGVKADSKAWCERTKNKLVNIEEENGTYKVTIEIINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAA7</accession>
    <name>L0AAA7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein, possibly involved in utilization of glycolate and propanediol</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0192"/>
    <dbReference type="EnsemblBacteria" id="AFZ69975">
        <property type="protein sequence ID" value="AFZ69975"/>
        <property type="gene ID" value="Calag_0192"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0192"/>
    <dbReference type="eggNOG" id="arCOG07054">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003337_0_0_2"/>
    <dbReference type="OMA" id="LIYRMDG"/>
    <dbReference type="OrthoDB" id="74261at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="273" mass="30313" checksum="3C15BCAAC3DAA2A9" modified="2013-03-06" version="1">MMKEVPDFLNLNLARKIINGMIKFSQDNNMLPGSYAVVDKGGHLIAFERRDNALPLTCDLAIDKAWTAATMLSARQLEVITSGQIWRLNVKYKGRLTIIPGTVPLISHNRVIGGIGHSGESPENDERISQAGLSSFYIEDDIKINVEPILSQSREIANELMEYVISNKLNPVAITITDEYGWPYLIYRMDGTPSGFLEISRDRAWTAAVFSKPSDEVEENISYTIGINWNERLNVSPGGIPFKLKGFSGAIGVAGNKPDVDKLIAINIIKKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAD7</accession>
    <name>L0AAD7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport systems, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232287.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0634"/>
    <dbReference type="EnsemblBacteria" id="AFZ70389">
        <property type="protein sequence ID" value="AFZ70389"/>
        <property type="gene ID" value="Calag_0634"/>
    </dbReference>
    <dbReference type="GeneID" id="14211894"/>
    <dbReference type="KEGG" id="clg:Calag_0634"/>
    <dbReference type="eggNOG" id="arCOG00926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="YLGAHHD"/>
    <dbReference type="OrthoDB" id="42569at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="240" mass="26409" checksum="9B7B8C3D527770C6" modified="2013-03-06" version="1">MLQISSLTKTFGKLKAVDNFSMEIEKGEVKALIGPNGAGKTTVVNLVTGVLEPDSGRIRVDNHCLLKLPPHKRTKMGISRTYQIPKPYPNLTVLENVLVSSYFGAGLKGEEAMANAVESLKFVGIYSMADKYAKELNSEQQKLLDFARALATRPKYIMIDEIGAGLGVGEQEEIASKIKELGKKGYGVLYIGHLMKMVKAVSDKVIVMNEGKKLFEGTYEEAVNNEEVIKIYLGEKYAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAH5</accession>
    <name>L0AAH5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_0264</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0264"/>
    <dbReference type="EnsemblBacteria" id="AFZ70045">
        <property type="protein sequence ID" value="AFZ70045"/>
        <property type="gene ID" value="Calag_0264"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0264"/>
    <dbReference type="eggNOG" id="arCOG00706">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_2"/>
    <dbReference type="OMA" id="AYPISHE"/>
    <dbReference type="OrthoDB" id="9593at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="625" mass="69701" checksum="30C05B5D11835EA9" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAJ4</accession>
    <name>L0AAJ4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphatase, C-terminal domain of histone macro H2A1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232347.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0704"/>
    <dbReference type="EnsemblBacteria" id="AFZ70449">
        <property type="protein sequence ID" value="AFZ70449"/>
        <property type="gene ID" value="Calag_0704"/>
    </dbReference>
    <dbReference type="GeneID" id="14211964"/>
    <dbReference type="KEGG" id="clg:Calag_0704"/>
    <dbReference type="eggNOG" id="arCOG04225">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_7_2_2"/>
    <dbReference type="OMA" id="HYGKGLP"/>
    <dbReference type="OrthoDB" id="78043at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="180" mass="19742" checksum="5327FC566AB2D71A" modified="2013-03-06" version="1">MHMFKLNNTVILIKLGDITQEEVEAIVNPANSYLIMGGGVAGAIKKKGGKIIEEEALKYSPIDIGKAVLTNAGKLKARFVIHSPTMKYPGELTNENNVRSSIKAALKIALEKGIKSIAFPGMGTGVGGISYNLGAKILIEEIKEFVEKNDHFEIIEIVAYEKEFYDELEKYAVSLLSNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAJ6</accession>
    <name>L0AAJ6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232015.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0340"/>
    <dbReference type="EnsemblBacteria" id="AFZ70117">
        <property type="protein sequence ID" value="AFZ70117"/>
        <property type="gene ID" value="Calag_0340"/>
    </dbReference>
    <dbReference type="GeneID" id="14211600"/>
    <dbReference type="KEGG" id="clg:Calag_0340"/>
    <dbReference type="eggNOG" id="arCOG04066">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1217517_0_0_2"/>
    <dbReference type="OMA" id="MATPWHL"/>
    <dbReference type="OrthoDB" id="109188at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009185">
        <property type="entry name" value="Nucleotidl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005928">
        <property type="entry name" value="Nucleotidltrnsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="242" mass="28553" checksum="DB525964B23F6060" modified="2013-03-06" version="1">MNNSFDKINHENLGQEVHYDEYRWRIFKKKRLRSLEILDSLKELGESIIVIGSVARGDVRENSDIDIFILGSIQSYKLEYILENKGYKIYNKEIIQATPNYAPKAYYYIDSDYKEVISFPLAKLNNNELEFYGWGGKISKNEILLNKRVPGVNKELKLIIPTDFGHIEYPIFGRESEVSRILNIKLETVLERERVLSRRKEIGKTGVFLKYEVPFDEPLDEAIEFLMKKNQFFAKRMMEYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAK8</accession>
    <name>L0AAK8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Calag_0356</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232030.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0356"/>
    <dbReference type="EnsemblBacteria" id="AFZ70132">
        <property type="protein sequence ID" value="AFZ70132"/>
        <property type="gene ID" value="Calag_0356"/>
    </dbReference>
    <dbReference type="GeneID" id="14211616"/>
    <dbReference type="KEGG" id="clg:Calag_0356"/>
    <dbReference type="eggNOG" id="arCOG01352">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_1_2_2"/>
    <dbReference type="OMA" id="PCFAAFP"/>
    <dbReference type="OrthoDB" id="40988at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="186"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="422" mass="46789" checksum="CD86DA809D546638" modified="2013-03-06" version="1">MATSKDPYLEAKKQLRSAVDILGYSDEIYEMLSTPERIVQVKIPVKMDDGKLKIFTGWRVQHNSALGPYKGGVRYHPETNLSEVMALAMWMTWKNSLADIPYGGAKGGIQVDPFQLSPRELETLSRKYFAGISKFVGVDLDVPAPDVNTNPQTMAWFVDEYSNRNDAQLFGVVTGKPLELGGLQTRIFSTGLGVATVAKQAAKKIFGSIEGRTVAVQGFGNVGFYTAKFLNEMGAKVIAISDVKGGIYSSKGFDADEIKATISKKGSMFVTDYPNYEKKISNEELLQLNVDILVPAAIENVITEENVSKIKAKLIVEGANGPTAPEAEEYLTKKGVVIVPDTLANSGGVIMSHIEWVNNRMGGWITEDEARNRLIQKMENNLDMIWNFWENKLDHEKYNLRMAAYGIAVDKVVRAMKLRGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAL0</accession>
    <name>L0AAL0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-amylase/alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232362.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0719"/>
    <dbReference type="EnsemblBacteria" id="AFZ70464">
        <property type="protein sequence ID" value="AFZ70464"/>
        <property type="gene ID" value="Calag_0719"/>
    </dbReference>
    <dbReference type="GeneID" id="14211979"/>
    <dbReference type="KEGG" id="clg:Calag_0719"/>
    <dbReference type="eggNOG" id="arCOG03279">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018719_0_0_2"/>
    <dbReference type="OMA" id="CGWFFEE"/>
    <dbReference type="OrthoDB" id="4093at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021923">
        <property type="entry name" value="DUF3536"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12055">
        <property type="entry name" value="DUF3536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="2">
        <location>
            <begin position="81"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="802" mass="93809" checksum="98AADFC244F2D95D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAL2</accession>
    <name>L0AAL2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PUA-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232035.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0361"/>
    <dbReference type="EnsemblBacteria" id="AFZ70137">
        <property type="protein sequence ID" value="AFZ70137"/>
        <property type="gene ID" value="Calag_0361"/>
    </dbReference>
    <dbReference type="GeneID" id="14211621"/>
    <dbReference type="KEGG" id="clg:Calag_0361"/>
    <dbReference type="eggNOG" id="arCOG00985">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090468_1_1_2"/>
    <dbReference type="OMA" id="HDHIEIL"/>
    <dbReference type="OrthoDB" id="85279at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022430">
        <property type="entry name" value="CHP03684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015266">
        <property type="entry name" value="DUF1947"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="PTHR22798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09183">
        <property type="entry name" value="DUF1947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03684">
        <property type="entry name" value="arCOG00985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="81"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="170" mass="19342" checksum="383F8537E7069D37" modified="2013-03-06" version="1">MSEKIKISKRHLLSKKEIKEVRDQILKEYPNLPMEWDKVEIAVYQDISFYLDNNFPCIVKKGDLIFPTLLCLLKRDNSWMNGVIIDRGATNAVSRGADLMLPGIKGVRGEFKEKSIIAAYDQDKGVPVMIGRSLYNSKEISDLIKQKAKGKAIENLHYSGDLIWKISVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAN2</accession>
    <name>L0AAN2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L14e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl14e</name>
        <name evidence="4" type="ordered locus">Calag_0389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232060.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0389"/>
    <dbReference type="EnsemblBacteria" id="AFZ70162">
        <property type="protein sequence ID" value="AFZ70162"/>
        <property type="gene ID" value="Calag_0389"/>
    </dbReference>
    <dbReference type="GeneID" id="14211649"/>
    <dbReference type="KEGG" id="clg:Calag_0389"/>
    <dbReference type="eggNOG" id="arCOG04167">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183474_0_0_2"/>
    <dbReference type="OMA" id="RRCNIKH"/>
    <dbReference type="OrthoDB" id="118643at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06088">
        <property type="entry name" value="KOW_RPL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00721">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023651">
        <property type="entry name" value="Ribosomal_L14e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_protein_L14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041985">
        <property type="entry name" value="RPL14_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="PTHR11127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="94" mass="10563" checksum="30D9FD531D16B1F8" modified="2013-03-06" version="1">MPAIEIGRVCIKTTGKELGRKCVIVDIIDQNFVLITGPKSLSGVKRRRTNIKHLMPTDKIINIKKGDSDEEVLNQLKNSNLTDFMKTKEKIVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAN3</accession>
    <name>L0AAN3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232065.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0396"/>
    <dbReference type="EnsemblBacteria" id="AFZ70167">
        <property type="protein sequence ID" value="AFZ70167"/>
        <property type="gene ID" value="Calag_0396"/>
    </dbReference>
    <dbReference type="GeneID" id="14211656"/>
    <dbReference type="KEGG" id="clg:Calag_0396"/>
    <dbReference type="eggNOG" id="arCOG00551">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1656796_0_0_2"/>
    <dbReference type="OMA" id="RSEATIM"/>
    <dbReference type="OrthoDB" id="141341at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="159" mass="17964" checksum="B3AA519C3011CEDE" modified="2013-03-06" version="1">MSEKIPAGGPYKAAIGIHEQLNADDIKDSRRLWSTYCTNDLELCKKFYDIIINISNLIAEARIEDIDSSTYQGIDKDFLNIMNSIKNNYSLYLSGSIISFGEFVLVKFNRGISLPNGKFIEKNEISLIPLEEAILLSSLKYVDPVTTLSYSIINKQKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAQ1</accession>
    <name>L0AAQ1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232401.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0760"/>
    <dbReference type="EnsemblBacteria" id="AFZ70504">
        <property type="protein sequence ID" value="AFZ70504"/>
        <property type="gene ID" value="Calag_0760"/>
    </dbReference>
    <dbReference type="GeneID" id="14212020"/>
    <dbReference type="KEGG" id="clg:Calag_0760"/>
    <dbReference type="eggNOG" id="arCOG06091">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_753554_0_0_2"/>
    <dbReference type="OMA" id="HEISMIM"/>
    <dbReference type="OrthoDB" id="132158at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="367" mass="41679" checksum="EA72F0F86762F8B4" modified="2013-03-06" version="1">MKPNYSKIMKIVHEISMIMVYISLIALIIALYIITRGFNLWHAKIMLLIFLPIFITGVSISYSSSSLKPNDNLAPIILFLQISSALLVLVLSIVTIITNKIYFLVISLLYFGIVNLINATRPKGDIRLSVALIGYTGILSAIFLILNNTKNVFEIAIGFIFVYAISLIYSVTIHSFPNTFKDKPNELLVYLLFILQTISTLIYQYYFKISVILFSISIIVFYLSINIFRYKKYSDFALNTTNVYAKAGTLYLLYGQAISALYSIVLLISSILFYFNIITLLDFIHLLIIGFVGIHIFIHAPLMLPVILRWTSARRYSLLPYILIVVAALIWPFDMHVAFLFLVLAIVFLVLIVKPSKEPIPLSLINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAQ2</accession>
    <name>L0AAQ2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70192">
        <property type="protein sequence ID" value="AFZ70192"/>
        <property type="gene ID" value="Calag_0424"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0424"/>
    <dbReference type="eggNOG" id="arCOG07461">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2055948_0_0_2"/>
    <dbReference type="OMA" id="RIIIRCH"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="119" mass="13495" checksum="D363EC2B197DCB10" modified="2013-03-06" version="1">MINLNHMSNEGKILIVCKNCQTILYRYVIGDKNDKNKFNGPPIPKKALSGFDRLTCPVCGEPLNLKPKSIRFFSFQMFNKLYEENGYKLIDKTKGSILNNMKGITQSSLSNEASVDDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAR9</accession>
    <name>L0AAR9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232416.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0777"/>
    <dbReference type="EnsemblBacteria" id="AFZ70519">
        <property type="protein sequence ID" value="AFZ70519"/>
        <property type="gene ID" value="Calag_0777"/>
    </dbReference>
    <dbReference type="GeneID" id="14212037"/>
    <dbReference type="KEGG" id="clg:Calag_0777"/>
    <dbReference type="eggNOG" id="arCOG13720">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1700175_0_0_2"/>
    <dbReference type="OMA" id="PNENIEK"/>
    <dbReference type="OrthoDB" id="142052at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="155" mass="17524" checksum="8071F40BCE639C98" modified="2013-03-06" version="1">MVELHPVGILAESNCFYIAAPIINAPWKPNENIEKIISNIINELKAWDISNYNLTKIEKAIYFSTIYGGLTLIYTCDPIVAISRIHTNISLSLKNSENNETKIMKDEDLLKAWAIIFNGNETEGLKILSGNLVFPKDYKWDIGGEYKIAARGIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAX3</accession>
    <name>L0AAX3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PriX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232073.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0406"/>
    <dbReference type="EnsemblBacteria" id="AFZ70175">
        <property type="protein sequence ID" value="AFZ70175"/>
        <property type="gene ID" value="Calag_0406"/>
    </dbReference>
    <dbReference type="GeneID" id="14211666"/>
    <dbReference type="KEGG" id="clg:Calag_0406"/>
    <dbReference type="eggNOG" id="arCOG05924">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1727151_0_0_2"/>
    <dbReference type="OMA" id="YVWVESI"/>
    <dbReference type="OrthoDB" id="122161at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040865">
        <property type="entry name" value="PriX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18689">
        <property type="entry name" value="PriX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PriX" evidence="1">
        <location>
            <begin position="48"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="151" mass="17804" checksum="4C9A122D6D7C8153" modified="2013-03-06" version="1">MVFEDVINNCQRSEIDCQKSIKELLKKYCPNPSDCSISIYRENLVQKFNWIEKIIKNGVPDGRTRLILYVISRYLINVKKLNDEEALNQINEFINNSCKNYNNCSQIYKSWIINVIGKVKNGKWKPWNMDKIRNSDPELYKVLEPIIGKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB02</accession>
    <name>L0AB02_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L18e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl18e</name>
        <name evidence="5" type="ordered locus">Calag_0552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232210.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0552"/>
    <dbReference type="EnsemblBacteria" id="AFZ70312">
        <property type="protein sequence ID" value="AFZ70312"/>
        <property type="gene ID" value="Calag_0552"/>
    </dbReference>
    <dbReference type="GeneID" id="14211812"/>
    <dbReference type="KEGG" id="clg:Calag_0552"/>
    <dbReference type="eggNOG" id="arCOG00780">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146465_0_0_2"/>
    <dbReference type="OMA" id="WRLERPR"/>
    <dbReference type="OrthoDB" id="104254at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00329">
        <property type="entry name" value="Ribosomal_L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022947">
        <property type="entry name" value="Ribosomal_L18e_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="4">
        <location>
            <begin position="41"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="119" mass="13632" checksum="05B5A3F4117DEB74" modified="2013-03-06" version="1">MRRQVTNEILLNTISSLRKQYKNTKSKIWLYAAELLSRPKRRRIAVNLNKINRFANDNDVILIPGKVLGEGRINKKVTIIAFSFSKEAIEKIRSSGGNYITIEEALKTYPEGKSIKILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB14</accession>
    <name>L0AB14_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0173 metal-dependent hydrolase Calag_1362</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0173 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1362"/>
    <dbReference type="EnsemblBacteria" id="AFZ71071">
        <property type="protein sequence ID" value="AFZ71071"/>
        <property type="gene ID" value="Calag_1362"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1362"/>
    <dbReference type="eggNOG" id="arCOG00497">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_4_0_2"/>
    <dbReference type="OMA" id="WHGHSTW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00457">
        <property type="entry name" value="UPF0173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022877">
        <property type="entry name" value="UPF0173"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="11"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="231" mass="25368" checksum="4E2BC085B290DC91" modified="2013-03-06" version="1">MSKMGSLIYYGHSAFEINSDGKKILIDPWITNPKSVTKPEKFKDVDLIVLTHGHDDHIGDTLEIMKNNPKSKVVAIFELANYIAEKLNDEHRAIGGNMGGPIIVDNIKIALVPANHSSEGYGAPTGAVIITKEGTIYHAGDTGITSEMQLIGEIYKPDIALLPIGGHFTMDHNEAAKAVEMIKPKVAIPMHYGTFPVLYGDPEEFRKIVISRGLNTNVVILKPGDKYEFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB72</accession>
    <name>L0AB72_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1616 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232561.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0933"/>
    <dbReference type="EnsemblBacteria" id="AFZ70664">
        <property type="protein sequence ID" value="AFZ70664"/>
        <property type="gene ID" value="Calag_0933"/>
    </dbReference>
    <dbReference type="GeneID" id="14212193"/>
    <dbReference type="KEGG" id="clg:Calag_0933"/>
    <dbReference type="eggNOG" id="arCOG02887">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124257_0_0_2"/>
    <dbReference type="OMA" id="RLDYSLW"/>
    <dbReference type="OrthoDB" id="120862at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011674">
        <property type="entry name" value="DUF1616"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07760">
        <property type="entry name" value="DUF1616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1616" evidence="2">
        <location>
            <begin position="76"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="187" mass="21646" checksum="31D3D00E3F84BCC2" modified="2013-03-06" version="1">MGLREEDIIKIIEKNSKIKIIDIINNMKNNNIKDVDIARFIYKLIEDNKIKYTNYPRNFLSYFFSIRNSWVLISLLIISVSMISSIFIPDKYILVKGILVSPILFFYPGYGVVESIYPNKNDWGELERVAIYIAISLAIIPLIGLILNLLPQGLTVLSVSLSLYIFSLSMLILSSYRKFNYYLMKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB84</accession>
    <name>L0AB84_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1448"/>
    <dbReference type="EnsemblBacteria" id="AFZ71153">
        <property type="protein sequence ID" value="AFZ71153"/>
        <property type="gene ID" value="Calag_1448"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1448"/>
    <dbReference type="eggNOG" id="arCOG03119">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1369584_0_0_2"/>
    <dbReference type="OMA" id="FISHFIP"/>
    <dbReference type="OrthoDB" id="85926at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="195" mass="22236" checksum="81DC107E110DE926" modified="2013-03-06" version="1">MVNNILYYFLLVFWISFISNVIPFGGPPYTIVTATILIQLNYIYFWELIIIASLGAILSKIIIYYSANIFRKPLSKNKNINLISKISNKYLFYIILFILAIIPVLPFDDYLYLAAGAARASLYKMILVTAIAKFSKTIIEILIELKVISLASYIFSISKPDVAILLTALFIIVGIIGFKIDWEKEYNKIKDAIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABA9</accession>
    <name>L0ABA9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type molybdate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233043.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1440"/>
    <dbReference type="EnsemblBacteria" id="AFZ71146">
        <property type="protein sequence ID" value="AFZ71146"/>
        <property type="gene ID" value="Calag_1440"/>
    </dbReference>
    <dbReference type="GeneID" id="14212700"/>
    <dbReference type="KEGG" id="clg:Calag_1440"/>
    <dbReference type="eggNOG" id="arCOG00219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709076_0_0_2"/>
    <dbReference type="OMA" id="KDAPNRE"/>
    <dbReference type="OrthoDB" id="43889at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="382" mass="42172" checksum="C2E1B8EA29F714BB" modified="2013-03-06" version="1" precursor="true">MKNIWIYLIIGLIIGLVIGISVGYASFPRKVVQYITTTTTTTKTTTSTSVFAVGAAGTLKFAFGSLLNLTSKYYPQLSVGTPMFKGSGEVASTENTTKEFSIVASADTTTIPKDLFPNVADYEIAFGVTQMVIIVDLQTSAGKQVYQLWQQAQTLPPNSSQYNQTWKEIFSIIAENPSTVVGVSNPFTDPSGYQAQCVLKLAGLTYFGNSSYLYDSVYNNVNKYQMRNTEIDLLTLMTTNNSVQFILSGYLSNALPQTQAYQKEGYNITYITLPPMINLGNLSYVNYYHQVNVTWSELGKTETFTCNPVVYTITIPKYAPNPQAAVNFILLIYSPLGQQILKSYGINPIYPGVVYGNYSDIPAVIKPYVVPVNQTNLETIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABB7</accession>
    <name>L0ABB7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA+ family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0588"/>
    <dbReference type="EnsemblBacteria" id="AFZ70345">
        <property type="protein sequence ID" value="AFZ70345"/>
        <property type="gene ID" value="Calag_0588"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0588"/>
    <dbReference type="eggNOG" id="arCOG01307">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_2_2"/>
    <dbReference type="OMA" id="ATIMSKW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Vps4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="SSF116846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="146"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="27"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="386" mass="44207" checksum="BCD5EA7471B99504" modified="2013-03-06" version="1">MSETNPVAMLEQTARRKMHEALDAERNKDYETAIDKYKRAMEALEEIIRNYPEHPMVKIYKKTINELNLRLKYLENKASQPIGETVSDEVRVEIKGDINDSLPDFVLKEKPSITFDDIAGLDEAKRAIKEAIIYPIKRPDLFPLGWPRGILLYGPPGTGKTMLAAAVANEINGEFIYLDAANIMSKWLGEGEKNVKKVFDYARNKSKNGIPVIVFIDELDALLGVHTNEVGGEVRVRNQFLKEMDGLQDKSITLHVYVIGATNKPWALDEPFIRRFQKRIYVPLPNKEARLKLLSMLTSKIKIDEGVNFDQLSEMLEGYSGSDIKDIVQDAYMIAVREYFESDGKSETVRPININDFNEAIKQRRPSVNKEMLKLYESWTERFKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABC1</accession>
    <name>L0ABC1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233090.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1491"/>
    <dbReference type="EnsemblBacteria" id="AFZ71193">
        <property type="protein sequence ID" value="AFZ71193"/>
        <property type="gene ID" value="Calag_1491"/>
    </dbReference>
    <dbReference type="GeneID" id="14212751"/>
    <dbReference type="KEGG" id="clg:Calag_1491"/>
    <dbReference type="eggNOG" id="arCOG02064">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094970_2_0_2"/>
    <dbReference type="OMA" id="WAMFKLL"/>
    <dbReference type="OrthoDB" id="100378at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032836">
        <property type="entry name" value="DsrE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13686">
        <property type="entry name" value="DrsE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="133" mass="14401" checksum="38BBE1A03DB4B38D" modified="2013-03-06" version="1">MSKLSIIVFSGTDDKLIPVGVIAQGAAALGMDVQIFVTGWALTKFIKKPANPVWPKEFESMVPLLMEGMKKNNAPSWADMLKEAKSMGAKVYACSLMASVMGLKREDFNELVDDIVGVATFLQNAEGGQTLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABD8</accession>
    <name>L0ABD8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232350.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0707"/>
    <dbReference type="EnsemblBacteria" id="AFZ70452">
        <property type="protein sequence ID" value="AFZ70452"/>
        <property type="gene ID" value="Calag_0707"/>
    </dbReference>
    <dbReference type="GeneID" id="14211967"/>
    <dbReference type="KEGG" id="clg:Calag_0707"/>
    <dbReference type="eggNOG" id="arCOG00001">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_11_0_2"/>
    <dbReference type="OMA" id="MKNERGH"/>
    <dbReference type="OrthoDB" id="121662at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="116" mass="13475" checksum="39328DE41B15715E" modified="2013-03-06" version="1">MPKERKKMLKGIISLMILKILYEKPVHGYEMNKEISLKIGEELSPGYIYVLLKIMLKKGLIVAKQDSNVRGQRLTEYRITEKGIEFLKKHKNVLEKGKSMIDEILDTINKIEQKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABF3</accession>
    <name>L0ABF3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein, family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0625"/>
    <dbReference type="EnsemblBacteria" id="AFZ70380">
        <property type="protein sequence ID" value="AFZ70380"/>
        <property type="gene ID" value="Calag_0625"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0625"/>
    <dbReference type="eggNOG" id="arCOG01533">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319962_0_0_2"/>
    <dbReference type="OMA" id="AYNESEY"/>
    <dbReference type="OrthoDB" id="6658at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="384"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="940" mass="103984" checksum="FDF07D285DD29541" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABG5</accession>
    <name>L0ABG5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0733"/>
    <dbReference type="EnsemblBacteria" id="AFZ70477">
        <property type="protein sequence ID" value="AFZ70477"/>
        <property type="gene ID" value="Calag_0733"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0733"/>
    <dbReference type="eggNOG" id="arCOG04275">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168009_0_0_2"/>
    <dbReference type="OMA" id="LYGLPMF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="119" mass="13762" checksum="6826BE6AA73B7FA6" modified="2013-03-06" version="1">MEEKIDEVFLIKVSSINDLARLASSMAAHMILMPIYRLMKNGKSTYFVQATYKDYYKYYGVPLVYYCEIAEDLNPEKAKYVLIRTDETGEKVEVSDKIKPGWIAIPIINIEEIPKFLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABJ7</accession>
    <name>L0ABJ7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233133.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1538"/>
    <dbReference type="EnsemblBacteria" id="AFZ71236">
        <property type="protein sequence ID" value="AFZ71236"/>
        <property type="gene ID" value="Calag_1538"/>
    </dbReference>
    <dbReference type="GeneID" id="14212799"/>
    <dbReference type="KEGG" id="clg:Calag_1538"/>
    <dbReference type="eggNOG" id="arCOG11607">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2379240_0_0_2"/>
    <dbReference type="OMA" id="YKINCKS"/>
    <dbReference type="OrthoDB" id="141563at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="94" mass="10836" checksum="38E4CA8332983B56" modified="2013-03-06" version="1">MIEEEIVEPGLCPYCNSPTDYTYHIEGPIMNDNEAYVEIKYKINCKSCGYSNSKSLYIPLNSFYLLKYMLTPKARIVLEKIKIVSDIKVVEKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABL0</accession>
    <name>L0ABL0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232333.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0690"/>
    <dbReference type="EnsemblBacteria" id="AFZ70435">
        <property type="protein sequence ID" value="AFZ70435"/>
        <property type="gene ID" value="Calag_0690"/>
    </dbReference>
    <dbReference type="GeneID" id="14211950"/>
    <dbReference type="KEGG" id="clg:Calag_0690"/>
    <dbReference type="HOGENOM" id="CLU_1163756_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="238" mass="28407" checksum="2667FFF18E32EAE4" modified="2013-03-06" version="1">MKWTEINVEVKNTDQEEIKKIFSKLIYYLVKEFKEMTNKRGSWHFLWESTPWPNTLKIRFYGSENAIDQIKKKFEEEYNNFKEDNKEILGEFIYGNNGVNGEEYEGEIIYYGVKGWKLVMKMLEFGSEIALELIRNKDLLESDEYSAQYPGSIDLYADRYVHLFLNQLSYFIKESEFLMKQLPFRYYVEKYGNAPQEAYLIETDIMLKTYLEKISSKYSQGKNQNKGLRLKNFNGQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABN0</accession>
    <name>L0ABN0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70532">
        <property type="protein sequence ID" value="AFZ70532"/>
        <property type="gene ID" value="Calag_0790"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0790"/>
    <dbReference type="eggNOG" id="arCOG05956">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170079_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="104" mass="11690" checksum="2E5F3CD56905A91B" modified="2013-03-06" version="1">MSRKRIFESMIADNVAKIASGLENPDDFNTPILASHVIEAVKKIGINLHTTKEGLLICYFCNKGPFTKKGYYLHLIRSHYYDLIDSVVRESERIASSSKDVGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABW4</accession>
    <name>L0ABW4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type ATP synthase subunit E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">V-ATPase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_1205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232821.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1205"/>
    <dbReference type="EnsemblBacteria" id="AFZ70924">
        <property type="protein sequence ID" value="AFZ70924"/>
        <property type="gene ID" value="Calag_1205"/>
    </dbReference>
    <dbReference type="GeneID" id="14212465"/>
    <dbReference type="KEGG" id="clg:Calag_1205"/>
    <dbReference type="eggNOG" id="arCOG00869">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1363591_0_0_2"/>
    <dbReference type="OMA" id="GGIKIYY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="200" mass="22540" checksum="B140366276362585" modified="2013-03-06" version="1">MTLAGNPKKVAEEIKEKNFVETKKLVDDAYSASLKLLNESYQAALNEFKKGLNDKSQELNESLKSVEASLQLELRKAVSEKRNKYIDDVFNNAINEIKKEKSKDWYINFMKKVISIISSEADSYNGLIVYTSEDDKDLVKKLTSQFKNIEVSQENANIIGGVIATNKDGTIKLDFSIDQIIKENEVFLKGIASEKLFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABX3</accession>
    <name>L0ABX3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl21e</name>
        <name evidence="6" type="ordered locus">Calag_1215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232831.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1215"/>
    <dbReference type="EnsemblBacteria" id="AFZ70934">
        <property type="protein sequence ID" value="AFZ70934"/>
        <property type="gene ID" value="Calag_1215"/>
    </dbReference>
    <dbReference type="GeneID" id="14212475"/>
    <dbReference type="KEGG" id="clg:Calag_1215"/>
    <dbReference type="eggNOG" id="arCOG04129">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103610_1_1_2"/>
    <dbReference type="OMA" id="KGMPHRR"/>
    <dbReference type="OrthoDB" id="107212at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00369">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_L21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_L21e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022856">
        <property type="entry name" value="Ribosomal_L21e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_L21e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="PTHR20981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="103" mass="11787" checksum="42F67DFB2494B477" modified="2013-03-06" version="1">MVKASTGYRSKTRNMLRKHIRERGGVPRLSKALYPYNIGDKVVIYINSSFHDGMPHRRFHGLTGTIVDKRGKAYVIKVNLGDKTKTIITYAVHLKPFTQQNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABY9</accession>
    <name>L0ABY9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1232"/>
    <dbReference type="EnsemblBacteria" id="AFZ70949">
        <property type="protein sequence ID" value="AFZ70949"/>
        <property type="gene ID" value="Calag_1232"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1232"/>
    <dbReference type="eggNOG" id="arCOG01000">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_1_2"/>
    <dbReference type="OMA" id="NTFPMIS"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="149"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="379" mass="42789" checksum="42D9FFCAEFB11933" modified="2013-03-06" version="1">MLDKIKENYDAVYLTNPTNIFYLTNVSIISTERPFALIIPVNGSPIAFSPSVEKNHIEYRNSMGGGIISNFYYYFDYPGEVHPLNKVVDLIKELKIKSIALDNPLGANPIWGYKGPNLSELLKKEGINVGKVEDLINEMRLIKSEEEIELIRESGKWASRAIRVAMDLIQENKWDWEIAIDASKQVLHEMNKNFSPYLPLRESIGLIVGFRGQVGEFSSYPHALVSERAIRKGDVLGIGSGPEIGGYYSELERTLIYGKPSEKVLNYFNKMLELRKEAFDTLRPNIKASDVDKAVMEKAKKLKVEEFIRHHTGHGLGLEGHEPPFLDVGYDVILKPGMVVSIEPGIYNDYGGFRHSDTVLITKNGNELLTNFPDEDLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC47</accession>
    <name>L0AC47_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232906.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1295"/>
    <dbReference type="EnsemblBacteria" id="AFZ71009">
        <property type="protein sequence ID" value="AFZ71009"/>
        <property type="gene ID" value="Calag_1295"/>
    </dbReference>
    <dbReference type="GeneID" id="14212555"/>
    <dbReference type="KEGG" id="clg:Calag_1295"/>
    <dbReference type="HOGENOM" id="CLU_2406191_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="92" mass="10736" checksum="305FA176610E665E" modified="2013-03-06" version="1">MEYENNVIVLNVKPTNDITISSKISSYELNLINMITEKCGISRSSFIRFSIHLALSTLFSEKEINDEWKPIIDQYKIEFENIIKKCKNNGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC74</accession>
    <name>L0AC74_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Triphosphoribosyl-dephospho-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232629.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1010"/>
    <dbReference type="EnsemblBacteria" id="AFZ70732">
        <property type="protein sequence ID" value="AFZ70732"/>
        <property type="gene ID" value="Calag_1010"/>
    </dbReference>
    <dbReference type="GeneID" id="14212270"/>
    <dbReference type="KEGG" id="clg:Calag_1010"/>
    <dbReference type="eggNOG" id="arCOG04238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1017807_0_0_2"/>
    <dbReference type="OMA" id="HDACINE"/>
    <dbReference type="OrthoDB" id="127247at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046917">
        <property type="term" value="F:triphosphoribosyl-dephospho-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002736">
        <property type="entry name" value="CitG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01874">
        <property type="entry name" value="CitG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="274" mass="31311" checksum="DB17EEDC519BF40C" modified="2013-03-06" version="1">MQCDLIPILSMGLYVEPSLYPKPGGITPFNHDDKNYFDFLIHASISSKIMHDACINEENSLLNALIEYKEYLINYGIKKNVAFGEFLLHIPLAISLKNSTNIMELTRNASNIIKNSGEKEGKIYYDILRILTPSYLGKYIGIMPDIFTSYPKSLYEVLKAYSWDLVNNELINNYSISLNALNYIKKFKNVKEGFLRGLLFIISNYGDTLTAKRNGFYFYKKMMMDAKVALRIADKYGIDFSINYLKSLWNNASPGSALDVLSTSISLYFLDSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC78</accession>
    <name>L0AC78_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1323"/>
    <dbReference type="EnsemblBacteria" id="AFZ71034">
        <property type="protein sequence ID" value="AFZ71034"/>
        <property type="gene ID" value="Calag_1323"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1323"/>
    <dbReference type="eggNOG" id="arCOG01984">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163428_0_0_2"/>
    <dbReference type="OMA" id="LECGSCR"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012206">
        <property type="entry name" value="Fd_FixX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43082">
        <property type="entry name" value="PTHR43082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036548">
        <property type="entry name" value="Fdx_FixX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="103" mass="11745" checksum="150C4B7B3F7E50F2" modified="2013-03-06" version="1">MSSTQVTEKKEEKPMKLEDILQSDIWNVDEDPHIIVDYNKCKNCPDKPCVYLCPAGCYVLSDNGIVFSYEGCVECGTCRVICPMEAITWNYPKSGKGIFYRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACC4</accession>
    <name>L0ACC4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232587.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0967"/>
    <dbReference type="EnsemblBacteria" id="AFZ70690">
        <property type="protein sequence ID" value="AFZ70690"/>
        <property type="gene ID" value="Calag_0967"/>
    </dbReference>
    <dbReference type="GeneID" id="14212227"/>
    <dbReference type="KEGG" id="clg:Calag_0967"/>
    <dbReference type="eggNOG" id="arCOG00082">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_1_1_2"/>
    <dbReference type="OMA" id="IRINHMG"/>
    <dbReference type="OrthoDB" id="20398at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="26"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="340" mass="38476" checksum="71A38F96F7D7F674" modified="2013-03-06" version="1">MIKYMTPGPIQLPNEVLDYIKRQPYFHRSNEFKEIFSSVLEKMEKIVKGNAIIFPGTGTLSIDTMVYNYVNPKEEVILLDIGEFSKRLGEALISRGARLYVIKSELGEVVPPDVLQDYAKKIKDLKAIAMVHNETSLGVANRYVEKIQEIAKSLDAVLLVDSVSGIPAERIDKEIDVIATASHKAFMSIPGASIIFYNVKPRNLDKLPLSMDLNKFINMKNKFETPYTPPINVIYGLDYSTSYILKIGLDRYTEIHKERSDYLNNLIKLKSIAKDEFKSNTVSAFYTNNAELIVKRLREKGYAIATGMGDLSKKVIRIGLMGDIDFNDIKNVAEVINEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACD3</accession>
    <name>L0ACD3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Zn-dependent protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232597.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0977"/>
    <dbReference type="EnsemblBacteria" id="AFZ70700">
        <property type="protein sequence ID" value="AFZ70700"/>
        <property type="gene ID" value="Calag_0977"/>
    </dbReference>
    <dbReference type="GeneID" id="14212237"/>
    <dbReference type="KEGG" id="clg:Calag_0977"/>
    <dbReference type="eggNOG" id="arCOG00322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_4_2_2"/>
    <dbReference type="OMA" id="LKGGMIG"/>
    <dbReference type="OrthoDB" id="49762at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="1">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="214"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="418" mass="47491" checksum="FCACD4F39B589629" modified="2013-03-06" version="1">MSEELSFIIKKALNDKIDAEIFHSKIKIFEIANDKNEQHGMTYEEDGYGLRIIKNKKLGFSYGNKISDDLYELAVSSSNASKEDNANYLPNEEEVTRLNGIFDEEIYNPIDKLKYYMESLGSISDKLNFINQRAIAGYTIIEIMNTNGLNVNSKTSFIYVGAVANYLGDEVGPEIFEGISSKRFNDINIEKLLNDLTFKIDIMKKRRKFENKKKQYNVIFTQKALDDLVVPLINHGISLESYYRNRTPFKLNDYFESKVTIVDDPLNPYLPWSREIDAEGLPSMKTEIIKEGVFKKFLSNTYWSKKANMDNTHSAFRAFTSLPVISTSNLVFQGKIINEDSDAIYIDQVQGVHTSNFETGDFSVSANVAWDKDGGFREIIVSGNIKQLINNVLGFTKDVSSYNKVYSGKMIVTGLSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACE4</accession>
    <name>L0ACE4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232704.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1085"/>
    <dbReference type="EnsemblBacteria" id="AFZ70807">
        <property type="protein sequence ID" value="AFZ70807"/>
        <property type="gene ID" value="Calag_1085"/>
    </dbReference>
    <dbReference type="GeneID" id="14212345"/>
    <dbReference type="KEGG" id="clg:Calag_1085"/>
    <dbReference type="eggNOG" id="arCOG00498">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048478_0_0_2"/>
    <dbReference type="OMA" id="WDLRAVW"/>
    <dbReference type="OrthoDB" id="55420at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="26"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="334" mass="38739" checksum="0D5F4ACC72A7A337" modified="2013-03-06" version="1">MENTSLEFPSWLHRIKVPIPIESLKYINVYMISDSNSFSLIDSGMYNMRSFHELSREIKKNGYKINEMESVIVTHFHVDHITLSPVLYSLGASDFYLGLKDEKVLRRGFDKFITKALKIYINHGMPPSEANEISKFHPAMKLVDVYTNDLQEIPWITMSNDSEIDLYGIKFKIIEVPGHTPGQINLYNKENDIIFTGDHILDPITPQITLTDENTDPLGDYLSSLEKISSLNAKIAFPGHKEPILNPSKRAKEIIKHHEERLNEIMKLISKNSLTAYEIAKKVKWRASYNSWEEYPYPERFFAMGETLAHLKRLEKLNLVEKKETKNVYTWSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACI2</accession>
    <name>L0ACI2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1043"/>
    <dbReference type="EnsemblBacteria" id="AFZ70765">
        <property type="protein sequence ID" value="AFZ70765"/>
        <property type="gene ID" value="Calag_1043"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1043"/>
    <dbReference type="eggNOG" id="arCOG05464">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1860607_0_0_2"/>
    <dbReference type="OMA" id="LNDECIG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="137" mass="15546" checksum="2CD0158BDD96787D" modified="2013-03-06" version="1">MVSNTPGPVKQGHDQGSHIAKSDNMQQSRELKPRPIGDKCNPLCPFFRCGQKALRFTTDHYRGRPIKVALCNWIGDRCIGASCRYAYCEKKAMLPDGRCSFAVENQPKKMKSFEEELNEENEIDLPQGYKGLPKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACI4</accession>
    <name>L0ACI4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major Facilitator Superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233021.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1417"/>
    <dbReference type="EnsemblBacteria" id="AFZ71124">
        <property type="protein sequence ID" value="AFZ71124"/>
        <property type="gene ID" value="Calag_1417"/>
    </dbReference>
    <dbReference type="GeneID" id="14212677"/>
    <dbReference type="KEGG" id="clg:Calag_1417"/>
    <dbReference type="eggNOG" id="arCOG02792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055959_0_0_2"/>
    <dbReference type="OMA" id="FVYITYG"/>
    <dbReference type="OrthoDB" id="77093at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="448" mass="48418" checksum="D9F3A8453A8875CB" modified="2013-03-06" version="1">MIYSVKILGEKVYTGFPWAAFVALSLGMIVFGLAESYGPLSALTQVVPSNLAWLAFTLPYIFGGIGAFISGYLADILGRKLAFILASGLVLLGMILYLPIWLNVVTGIARTITLLISIAIVGMAAIGLESPVLAMISESVSSQHRSKLLVLGPNFGNLGVALAYVPLLIFGINNAKASAYNYELALILMYIAPTIGLILAWLKATETLPWKAIKTKKNVEEAWKAIDKNSEVVNPNAGLGFRLLTLILIGIVQDVAFVYITYGASYAYFSNIAEYVPLIGGFTMTIVGIITGLFITSKVSRKVFAVISYSMLAVFWVLLWGVASITNSSIAILSMFTLLMIPVETTWATRALLEPELFPTNRRGMLISLVRFVVWVSAGIIAGLLILIPLSFTIGALSMFIIALAGVGGALFWYYKGFETGNKNLLGLDLQESMRKIAPVKASDPKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACK9</accession>
    <name>L0ACK9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component Csl4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">csl4</name>
        <name evidence="6" type="ordered locus">Calag_1161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CSL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232779.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1161"/>
    <dbReference type="EnsemblBacteria" id="AFZ70882">
        <property type="protein sequence ID" value="AFZ70882"/>
        <property type="gene ID" value="Calag_1161"/>
    </dbReference>
    <dbReference type="GeneID" id="14212421"/>
    <dbReference type="KEGG" id="clg:Calag_1161"/>
    <dbReference type="eggNOG" id="arCOG00676">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067135_1_1_2"/>
    <dbReference type="OMA" id="CGNVETR"/>
    <dbReference type="OrthoDB" id="111542at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00975">
        <property type="entry name" value="Exosome_Csl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030850">
        <property type="entry name" value="Exosome_Csl4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="PTHR12686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ECR1_N" evidence="5">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="210" mass="23486" checksum="922FC98F23011676" modified="2013-03-06" version="1">MYYSLKNNVVVPGEVIAQQEEFVEGEGVYIDTETGYLRSMFLGKIAIDFNNRTISVNSYKKLKLPKKNSIVLGSVSSVRENIIFVDIYGVIVLYPRPKWEFEFSSPLSGAIISNQVGVDKFNDLMDIVKPGDIILAKVINSSNPYNLSLKGPQYGVIYSMCSKCGEIMIPQNNDQLKCPKCGNVEKRKISNLATSKLLKIDMKKTILMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACM7</accession>
    <name>L0ACM7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA-binding protein of the translin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233076.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1477"/>
    <dbReference type="EnsemblBacteria" id="AFZ71179">
        <property type="protein sequence ID" value="AFZ71179"/>
        <property type="gene ID" value="Calag_1477"/>
    </dbReference>
    <dbReference type="GeneID" id="14212737"/>
    <dbReference type="KEGG" id="clg:Calag_1477"/>
    <dbReference type="eggNOG" id="arCOG04318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099315_0_0_2"/>
    <dbReference type="OMA" id="EKTHGDI"/>
    <dbReference type="OrthoDB" id="100043at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="PTHR10741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741:SF2">
        <property type="entry name" value="PTHR10741:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="SSF74784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="215" mass="24680" checksum="727A09A5433E4456" modified="2013-03-06" version="1">MQEKKNKIGDIIKSVDTYLKKLDSIREEIVKISRDVIRYSGWSITEAHKGDIDSALNYLHECENKAKELIKLSLNAPELTYSGLVYNALSEFVEAKVFLNIITNKEIPTNDDLNVPPVPYLQGLGDVVGELKRYALESVRKGNFDNAWKSLEIMETIYLEMRSLDYSDSILPGVRHKIDVARNLVDETKSLIVDLQSRENLKVMLNNLMERKYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACN1</accession>
    <name>L0ACN1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="4">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsY</name>
        <name evidence="6" type="ordered locus">Calag_1482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1482"/>
    <dbReference type="EnsemblBacteria" id="AFZ71184">
        <property type="protein sequence ID" value="AFZ71184"/>
        <property type="gene ID" value="Calag_1482"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1482"/>
    <dbReference type="eggNOG" id="arCOG01227">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_3_4_2"/>
    <dbReference type="OMA" id="GISDQFQ"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="5">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="116"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="198"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="256"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="304" mass="33874" checksum="122B872BE3BB1E2A" modified="2013-03-06" version="1">MFEGLKKAFQKLSNTIKDKVEYKELKEDDVEEVLEDLKLDMIENDVAFDVAENIIENVKKELIGYKVKRGESVEDVIKDSLKNSIMKLMEYENNDIITKIKNKCSKNEPFVIVFLGINGVGKTTTIAKFSNVLKKNNISVVIAGADTFRAGAQEQIDVHAKRLDIPIIKGQYGGDPASVAYNAILYAKSRGICTVLIDTAGRMHSDVDLMEELKKIIRVTKPDMKVLVVDALTGNDAVEQARLFNDNIGIDAIIITKIDADVKGGVAISVSSITKKPIIYLGYGQSYEDLKKFDPKEYVNNLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACQ9</accession>
    <name>L0ACQ9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1213"/>
    <dbReference type="EnsemblBacteria" id="AFZ70932">
        <property type="protein sequence ID" value="AFZ70932"/>
        <property type="gene ID" value="Calag_1213"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1213"/>
    <dbReference type="eggNOG" id="arCOG04292">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161132_0_0_2"/>
    <dbReference type="OMA" id="KDFIAPP"/>
    <dbReference type="OrthoDB" id="118739at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="124" mass="14690" checksum="69337958133534AE" modified="2013-03-06" version="1">MKEIHMKIEPGNYRSVKLELSDAIELLNKVVSLRGIETKDINESFRILNNFDEFYEYQKKKFKDYVTPDKDVSDMIRGAVVVDNLKLIKENNKKYVVITFDRRLKEELIIKALNNMGYEVKIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACU3</accession>
    <name>L0ACU3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uroporphyrin-III C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232772.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1153"/>
    <dbReference type="EnsemblBacteria" id="AFZ70875">
        <property type="protein sequence ID" value="AFZ70875"/>
        <property type="gene ID" value="Calag_1153"/>
    </dbReference>
    <dbReference type="GeneID" id="14212413"/>
    <dbReference type="KEGG" id="clg:Calag_1153"/>
    <dbReference type="eggNOG" id="arCOG00644">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_7_0_2"/>
    <dbReference type="OMA" id="TRPEQEE"/>
    <dbReference type="OrthoDB" id="67633at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="246" mass="27139" checksum="C9A52DA8E0C97214" modified="2013-03-06" version="1">MNGKVFIVGAGPGDPELITVKALNLIKNADVLIYDRLVSKKLLEYCKSDCELIYVGKSPGKHEMEQEKINEMLVNKAMEGKTVVRLKGGDPYIFGRGEEECSYVIEKGILCEVVPGIPSFIGAAVYAGIPLTNRNISSSFSVITGKEAEEKKISNVKLEEIAKASNTIVILMGISTIKENLETIARVKGYDEKCAIVMNATTDSQRVFVGTIKEILDNYENLHLENPAIIIIGKIVNMRDKLWKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACY9</accession>
    <name>L0ACY9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_1201</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1201"/>
    <dbReference type="EnsemblBacteria" id="AFZ70920">
        <property type="protein sequence ID" value="AFZ70920"/>
        <property type="gene ID" value="Calag_1201"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1201"/>
    <dbReference type="eggNOG" id="arCOG04537">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_0_1_2"/>
    <dbReference type="OMA" id="CDDVIMD"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="6">
        <location>
            <begin position="406"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="491" mass="54746" checksum="119C5A2A75EE9934" modified="2013-03-06" version="1">MVSLPQILIKRPEVDSFYTFSTVELPEQYCRGLACFASRSLNEKIFSKSKVQIPRTYCLGFCYAGPSYSKGYYKRPIIDIKTKKSVLLKDIVKDRIYDIEQYISLDGLSALKKALNMEPIDIIKEVKESGLRGRGGAYFPTGLKWESAYNQREEERYLIINGDEGDAGAYIDKVLMEDNPYLVIEGALIAAYAIGAKTIYIYVRKEYPFAYETMKKAINEFKNKGLIGTNALKGRSINIILEKGKGSYVVGEETAMINAIMGLRGEPRARPPYPTELGLFNKPTVVNNVETISNIPWIIKNSGKSYYELGFNKSRGTKLISLNNLFNKPGVYEVEFGISLNEIVYNIGDGLKNNLPLKMLIIGGPLAGPILPNELDTKLGVEELRNINASLGHGNIIAFSNDTTAFDLLYEIIDFAAYESCGKCFPCRFGTQSLLSIVENAKKRGYFTKEESNSIERIARVMKSQSLCGHGVGTGDAVLSIINKLRDEVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD25</accession>
    <name>L0AD25_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1333"/>
    <dbReference type="EnsemblBacteria" id="AFZ71042">
        <property type="protein sequence ID" value="AFZ71042"/>
        <property type="gene ID" value="Calag_1333"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1333"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="ASHMLSE"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="263" mass="29446" checksum="F8967B89B0685789" modified="2013-03-06" version="1" precursor="true">MNYIMSKTVEVPIDNNTQYSIIAEKLYKKIGKKEVLKGIDLKIRKGEIHVIAGHNGAGKTTLFRILAGLLKYDSGKLLVMGFDPSKNQNEIRKYLGYVPEDSSPYDRLTGFENLKLFALIYSNGNESLAEKYIKHGAEISELSYEDLSRKASEYSNGMKKRLLIARAMMHDPKLVLLDEPTNGLDVFSAYKVRKLIKTMSNSGTTFVIATHNMSEAEMLADNVSFIAYGTVLYSGSVKAAIEEFKSVNLEEAFIKAVGEKYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD31</accession>
    <name>L0AD31_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="2">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232857.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1243"/>
    <dbReference type="EnsemblBacteria" id="AFZ70960">
        <property type="protein sequence ID" value="AFZ70960"/>
        <property type="gene ID" value="Calag_1243"/>
    </dbReference>
    <dbReference type="GeneID" id="14212503"/>
    <dbReference type="KEGG" id="clg:Calag_1243"/>
    <dbReference type="eggNOG" id="arCOG01068">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_3_2"/>
    <dbReference type="OMA" id="DAKYGEW"/>
    <dbReference type="OrthoDB" id="19112at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="4"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="315"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="436" mass="48117" checksum="BD9D935F18EC507F" modified="2013-03-06" version="1">MELYDLIVIGGGPAGYPAAIRASQLGLRVALIEKNKLGGECTNYGCIPTKALIKSSYENKDFKDAIEEAISASDKVREGISFLLKNNKVDVFYNEAKIEENNEMFIEENNNIKSKKLIIATGTEPIDLPNLKVDGKLIHNNRTILNLKEKPSSLLIIGAGYVGVEFANAFSKLDSKVTLIEAMPRILPNLDPDISRLAERSLRNKGIKIYKNTTIKEVKEIRENYIKININNEDMEFDSVLISIGRKPVLPNIKVERDEKSFIKTDKYLRTSNPNVFAAGDITGNPMLAHKAFVQGVVAAEGILNMLKEIDYNIIPSVVFSNPEIFSVGYTLNQANSLGLNARETKLPLGGLARSVIEKEEIGLIKIVYDSSNRIIGVHAIADHASEIALSATLAVKLKASLEDLSFSMPPHPTMSEALKEVAELALNRPIHYTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD42</accession>
    <name>L0AD42_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232954.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1348"/>
    <dbReference type="EnsemblBacteria" id="AFZ71057">
        <property type="protein sequence ID" value="AFZ71057"/>
        <property type="gene ID" value="Calag_1348"/>
    </dbReference>
    <dbReference type="GeneID" id="14212608"/>
    <dbReference type="KEGG" id="clg:Calag_1348"/>
    <dbReference type="HOGENOM" id="CLU_873200_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="318" mass="36892" checksum="66E3D3F3D134E245" modified="2013-03-06" version="1">MKSFQNKHINIDIFIFSLIIASYFIQFISIQFFVRLEPYFMGAFTLPSIVNIIISKLALISRYLIELLGIVGSIYFIFNKNKIISILSMLYFILMIIPFIVISYSQNIYINYVTNPFGLTLISMSSLIPSLAILLDYKKNKNYFSTLATKLIFGISMLLSSLFFILNYTSSFTFLYPPIELYPISLIFFSLGFIIFTYMALKKSNKYAIIASAIISLLLIIPLIYYSFTNTLFKFVFNMSMQTALGIAVPLPYFSFLYFIILFIFLIGLFNIKKNYHMFFASIALIGIFTSAYLISDTMYMFLIYLFTMIFIISFEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD44</accession>
    <name>L0AD44_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flp pilus assembly protein TadB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1253"/>
    <dbReference type="EnsemblBacteria" id="AFZ70970">
        <property type="protein sequence ID" value="AFZ70970"/>
        <property type="gene ID" value="Calag_1253"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1253"/>
    <dbReference type="eggNOG" id="arCOG01812">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081491_0_0_2"/>
    <dbReference type="OMA" id="IAIPRIM"/>
    <dbReference type="OrthoDB" id="136838at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="133"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="308" mass="34219" checksum="2EC239EE66B0A6B5" modified="2013-03-06" version="1">MIRIKLEIDFKEILLKINKILYQFYNNIKPCNLIRKLSPNIDYMILGSGVSDSFDNYCKKLVTLIFLFIPTLLWEFIYIYMSYSGKYTLENIIVASILIVILGYLLSAGISVLIPSFRYSSRKDDLEAKFHVFASTLTSLLAGGEGISQALSTFSEKYADELKEFNVEMTYIKTSTKLNESPTDILLGLSKITPSPSLKLLAQSLARGITAGADLVQIAQDSISSYLNYYYSLVERISTSIGTLLESFLVVGIVGPVLVGVMGMLFTVYPVTTLSFSSLIILVIFILIPIVSLITAVLADNQTSKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD53</accession>
    <name>L0AD53_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1358"/>
    <dbReference type="EnsemblBacteria" id="AFZ71067">
        <property type="protein sequence ID" value="AFZ71067"/>
        <property type="gene ID" value="Calag_1358"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1358"/>
    <dbReference type="eggNOG" id="arCOG05994">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2177761_0_0_2"/>
    <dbReference type="OMA" id="MRMTLPK"/>
    <dbReference type="OrthoDB" id="143345at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="109" mass="12522" checksum="A0BF3E095C871C98" modified="2013-03-06" version="1">MSSERKRMELPKKKEDLEKIVEEVEAGHEHEHEHEHEHEHEHIEDVISVLELLVDSLSANVKNLDSSVKGQGKEIVNIYRILSYLVEACTTNDQNSKNEALKKAISLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD58</accession>
    <name>L0AD58_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232882.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1269"/>
    <dbReference type="EnsemblBacteria" id="AFZ70985">
        <property type="protein sequence ID" value="AFZ70985"/>
        <property type="gene ID" value="Calag_1269"/>
    </dbReference>
    <dbReference type="GeneID" id="14212529"/>
    <dbReference type="KEGG" id="clg:Calag_1269"/>
    <dbReference type="eggNOG" id="arCOG11224">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2406190_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="92" mass="10697" checksum="2E7348ECDF02C6EE" modified="2013-03-06" version="1">MGKDTNDLAELVDETIKKVALGLYVNMNYYSYAKYQKPIKILILEEPIHAFDLIKNISSINTARLLFKIIMRALNFDLANIDSIIRFFRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD78</accession>
    <name>L0AD78_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Geranylgeranyl reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1291"/>
    <dbReference type="EnsemblBacteria" id="AFZ71005">
        <property type="protein sequence ID" value="AFZ71005"/>
        <property type="gene ID" value="Calag_1291"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1291"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_0_0_2"/>
    <dbReference type="OMA" id="WYFPRTE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="455" mass="50685" checksum="B95C4F2CCC7926E0" modified="2013-03-06" version="1">MTKNYKFDVVIVGLGPAGSTLAYFLKNSGLNVAGIDMVDEDGLWGKPCGDAIGKHHFEETGLPFPEGKELSQKVDGIDIISPKKDIVLRVQGEGFVINRNQYGRKLVKEAEKSGISIFLKTRVTSPKIQDNKLIGVSAILPNGENALFEGNIIVDATGNGGLLRRLLPKEWPPNEPLNPLDTNIAYREIRDLNYDIEEPSYLRIYLDQEISPGGYWWYFPEGKNRANIGLGVQGGMNYPTPNTIFKTRLEQIDIVKNHTDVINASGSKVPTRRPANTLVWNNFIGIGDNGFTVNPVHGGGMGYAFVSSYYSSQTIINAFQNKDFSAKSLWEANLKYVKAIGKRQAALDIFRIFLQRLSNDDIEYGLKHGVMKAQDAYETSVTGELKANMGLLEKATLALKMLGRPSLLSKLVIVDDYMKKVQKVYDVYPQSPLELNDWVSYVTSLYKEYKAKLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADL5</accession>
    <name>L0ADL5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233022.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1418"/>
    <dbReference type="EnsemblBacteria" id="AFZ71125">
        <property type="protein sequence ID" value="AFZ71125"/>
        <property type="gene ID" value="Calag_1418"/>
    </dbReference>
    <dbReference type="GeneID" id="14212678"/>
    <dbReference type="KEGG" id="clg:Calag_1418"/>
    <dbReference type="eggNOG" id="arCOG04348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_12_0_2"/>
    <dbReference type="OMA" id="FEYMPFR"/>
    <dbReference type="OrthoDB" id="45753at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="66"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="246" mass="27939" checksum="40125A94D51EC46A" modified="2013-03-06" version="1">MLKNDNKVNGNQGLEEKFWKNIVSEIETYSEKGCYEKVNTLMSFFVLKRLRIIASALAKGSNIIIDVGNGPGTSTKYIKGILNPSHLIAMDPSFAMNKITKDNIKNISVINGMAENIPVKSSSIDAVIAMFSFRDVRNYDLALREFSRVLKENGKLIILDLYKPETVMEKIISFFQFNILAVVFGIVMGCGRDALLYPDLHKTIYYMYNSKEILKSVNKYFKKVSFKKKPIIVGILWASDPRKDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADM3</accession>
    <name>L0ADM3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase, beta-lactamase superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233129.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1533"/>
    <dbReference type="EnsemblBacteria" id="AFZ71232">
        <property type="protein sequence ID" value="AFZ71232"/>
        <property type="gene ID" value="Calag_1533"/>
    </dbReference>
    <dbReference type="GeneID" id="14212794"/>
    <dbReference type="KEGG" id="clg:Calag_1533"/>
    <dbReference type="eggNOG" id="arCOG00503">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036012_0_0_2"/>
    <dbReference type="OMA" id="CSGWRAK"/>
    <dbReference type="OrthoDB" id="73329at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="33"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="268" mass="29740" checksum="752A9EA7211016D1" modified="2013-03-06" version="1">MKLTILVDNYVTSLTSLRDRLMSEWGFAAYLHDYKVLYDTGLSGDVLLNNMKALNLDLNEPEYIVLSHRHLDHTGGLMKFLNQRNKPIKVIAHKNLFAPARAKDEKGEVSVGVNFTKEELEKKNAELILIDSPYKLKENLIVSGYIPRNWGPSHAGGLIDEIPDDMALYIIDNDELLILTGCGHAGIENIVEYGLKITGLNKLKGIIGGLHFMGLDDKRLNTIVSYLNKKAPKIVAGTHCTGIDGISLLKRSFPNSFKDAGVGKELII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADP5</accession>
    <name>L0ADP5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0201 protein Calag_1456</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0201 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233057.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1456"/>
    <dbReference type="EnsemblBacteria" id="AFZ71160">
        <property type="protein sequence ID" value="AFZ71160"/>
        <property type="gene ID" value="Calag_1456"/>
    </dbReference>
    <dbReference type="GeneID" id="14212716"/>
    <dbReference type="KEGG" id="clg:Calag_1456"/>
    <dbReference type="eggNOG" id="arCOG01043">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134829_1_0_2"/>
    <dbReference type="OMA" id="VHKQVAY"/>
    <dbReference type="OrthoDB" id="106305at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01112">
        <property type="entry name" value="UPF0201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39652">
        <property type="entry name" value="PTHR39652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="146" mass="16821" checksum="41F99FFE094ABEB5" modified="2013-03-06" version="1">MENGKIIVEAELRPTEDEEKVIKAINNVFTCENMEITDQGDYKIIRCSSNSYKSLNKFHELLRRQAILDAARSYFFKRIKGNKLLILLHKQAAYSGKISFISWDEESPLGPIKIIIESKDINSVIDWLSPQTVRGKPLWERGPPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADQ4</accession>
    <name>L0ADQ4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoesterase, ICC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233067.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1467"/>
    <dbReference type="EnsemblBacteria" id="AFZ71170">
        <property type="protein sequence ID" value="AFZ71170"/>
        <property type="gene ID" value="Calag_1467"/>
    </dbReference>
    <dbReference type="GeneID" id="14212727"/>
    <dbReference type="KEGG" id="clg:Calag_1467"/>
    <dbReference type="eggNOG" id="arCOG01145">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_5_0_2"/>
    <dbReference type="OMA" id="HGKFFRL"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="197" mass="22127" checksum="162991770A411080" modified="2013-03-06" version="1">MTTKIIHISDIHCNNKMLEKIKELDYDVLISSGDFECLETAEIFSEFRNSFAVSGNVDDVSIMKLLSKKGILLDGKIKTVNEIAFIGIGGIDPINNISVIKNYPFNKKYKYVILVSHNPPYGILDKTFFNIRAGLKEINSILNYIKPSIHLFGHIHESQGIQLLNNTIYINPGPLDIGNYAEIILDDSIKAEIKNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7F5</accession>
    <name>L0A7F5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">DNA repair and recombination protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">radA</name>
        <name evidence="11" type="ordered locus">Calag_0007</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the eukaryotic RecA-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231701.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0007"/>
    <dbReference type="EnsemblBacteria" id="AFZ69803">
        <property type="protein sequence ID" value="AFZ69803"/>
        <property type="gene ID" value="Calag_0007"/>
    </dbReference>
    <dbReference type="GeneID" id="14211268"/>
    <dbReference type="KEGG" id="clg:Calag_0007"/>
    <dbReference type="eggNOG" id="arCOG00415">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_0_0_2"/>
    <dbReference type="OMA" id="TFRIYLR"/>
    <dbReference type="OrthoDB" id="30130at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01123">
        <property type="entry name" value="Rad51_DMC1_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00348">
        <property type="entry name" value="RadA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011938">
        <property type="entry name" value="DNA_recomb/repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033925">
        <property type="entry name" value="Rad51_DMC1_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02236">
        <property type="entry name" value="recomb_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="9">
        <location>
            <begin position="89"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="10">
        <location>
            <begin position="265"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ69803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="327" mass="36331" checksum="0887B1F8C2C41EAF" modified="2013-03-06" version="1">MSEENTNNEQEKARPKDITDLPGVGPNTAQKLIESGYTSIEAIAVATPQEIAQVTGIPLPSAQKIVSAARETLDIKFRTALELKKERLNIHKITTGSKSLDDLLGGGIETRDMTEFFGEYGTGKTQICHALAVNVQLPEDKGGLNAKAVYIDTEGTFRWERIEQIARGLNLDPDKVMENIYWIRAVNSHHQMAIVDQLYDMLSKDNVKLVIVDSLTSHFRAEFPGRENLAMRQQLLNKHLHQLIRLSEIYDIAVVVTNQVMARPDVFYGDPTSAVGGNIVAHAPGVRVQLKRSRGNKRIARIVDAPHLPEGETVFVITEYGIKDAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7K6</accession>
    <name>L0A7K6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ69801">
        <property type="protein sequence ID" value="AFZ69801"/>
        <property type="gene ID" value="Calag_0005"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0005"/>
    <dbReference type="eggNOG" id="arCOG08093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202941_0_0_2"/>
    <dbReference type="OMA" id="CKKNTFH"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="50" mass="6257" checksum="A7DB076E0FD86F81" modified="2013-03-06" version="1">MTKWKLRCKECKNEWVLPVSFEIDKMKNFYHYCPYCKKNTFHEPVKKLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7S6</accession>
    <name>L0A7S6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231779.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0093"/>
    <dbReference type="EnsemblBacteria" id="AFZ69881">
        <property type="protein sequence ID" value="AFZ69881"/>
        <property type="gene ID" value="Calag_0093"/>
    </dbReference>
    <dbReference type="GeneID" id="14211353"/>
    <dbReference type="KEGG" id="clg:Calag_0093"/>
    <dbReference type="eggNOG" id="arCOG06030">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2216919_0_0_2"/>
    <dbReference type="OMA" id="ATWGEYY"/>
    <dbReference type="OrthoDB" id="99867at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021585">
        <property type="entry name" value="Ta0938"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11494">
        <property type="entry name" value="Ta0938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="106" mass="12119" checksum="E1C312ACE155A2A9" modified="2013-03-06" version="1">MKVIVNGKEAGTKETGCALCGGTWGDYYETVEGEKLFFCCNICAKAFINIINEAKKRFNLNKIDYIELRGNFYRGRNIEVKNGENSHKFYIKLSDDGDITEFKEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7S8</accession>
    <name>L0A7S8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231826.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0141"/>
    <dbReference type="EnsemblBacteria" id="AFZ69928">
        <property type="protein sequence ID" value="AFZ69928"/>
        <property type="gene ID" value="Calag_0141"/>
    </dbReference>
    <dbReference type="GeneID" id="14211401"/>
    <dbReference type="KEGG" id="clg:Calag_0141"/>
    <dbReference type="eggNOG" id="arCOG01617">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_2"/>
    <dbReference type="OMA" id="VDLWQVH"/>
    <dbReference type="OrthoDB" id="43721at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="342" mass="39156" checksum="EEF20B285AED1FBC" modified="2013-03-06" version="1">MEYINLGWSGTKVSKICLGTMSFGDPSLQLYGKGGWIVGREQALKILEKAWDLGINFFDTANVYSKGSSEKILGEFLFGRRDDAVIATKVYFPMSDKPNDRGLSRKHVMKQVKDSLLRLKTDYIDLYQMHRWDYETPIEETLSTFNNLVSEGFIRYYGLSAVFGWQLAMVYYLAMAKGWERPVSIQSLYNLLYREDEREVLPFAKMHRLTYLAYSPTAVGILTGKYFIGGKIVIPEDKESTPERLWSNSNYYAKSIYVGPPDNDEIMKRLIELAQEKGVKPSQIAIAWLLHKGVIPIIGTSKVEHLEELVEAIMIKLTDKEIDDLEKPYKPKPFVHAIPPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7U9</accession>
    <name>L0A7U9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231804.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0118"/>
    <dbReference type="EnsemblBacteria" id="AFZ69906">
        <property type="protein sequence ID" value="AFZ69906"/>
        <property type="gene ID" value="Calag_0118"/>
    </dbReference>
    <dbReference type="GeneID" id="14211378"/>
    <dbReference type="KEGG" id="clg:Calag_0118"/>
    <dbReference type="eggNOG" id="arCOG00494">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_1_0_2"/>
    <dbReference type="OMA" id="WPEMVDN"/>
    <dbReference type="OrthoDB" id="26718at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="354" mass="39828" checksum="79A548F635194D53" modified="2013-03-06" version="1">MKFNVVVVGSTGLVGQRLVSMLSKHQWFNLIGITASKDKANKKYKDVVKWSLENKMPENVEEMIVYDTNIENINNLKPDIVFTSLPTDISKDFDIQLVKQGYVVISHASNNRMDKDVPLLNPEVNADHINVLKLQANRWKGRLIKVPNCATSILTLALKPIYDNFGLRHVFVSTMQALSGAGINGVSSMAILDNIIPYIEHEEEKIENESLKILGELSNESIKPNESFYVSASVHRVNVLEGHLESVFLKTDNDVSVEEIKKSLIEFKENKIKNLNLPTKPSQPIIVRNEIDRPQPRLDRNEGNGMSIVVGRIRKDNRNWIKFNVLGHNTIRGAAGNGVLIGELVAKNYNDIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A807</accession>
    <name>L0A807_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps24e</name>
        <name evidence="5" type="ordered locus">Calag_0221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231901.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0221"/>
    <dbReference type="EnsemblBacteria" id="AFZ70003">
        <property type="protein sequence ID" value="AFZ70003"/>
        <property type="gene ID" value="Calag_0221"/>
    </dbReference>
    <dbReference type="GeneID" id="14211481"/>
    <dbReference type="KEGG" id="clg:Calag_0221"/>
    <dbReference type="eggNOG" id="arCOG04182">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107248_3_2_2"/>
    <dbReference type="OMA" id="HETAKIY"/>
    <dbReference type="OrthoDB" id="124805at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_S24e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="PTHR10496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="107" mass="12418" checksum="DCFAE3E502F13EEA" modified="2013-03-06" version="1">MSKKINIDNDVYLEVLDEKENKLLERLEVYGIVHHELKSTPSRITLRKILSQAYSKDISQIFVKSIKTSYGQGISNVHIHIYNTPEFAKKYELKYIVDRNGGYTLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A857</accession>
    <name>L0A857_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative endonuclease (RecB family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0234"/>
    <dbReference type="EnsemblBacteria" id="AFZ70016">
        <property type="protein sequence ID" value="AFZ70016"/>
        <property type="gene ID" value="Calag_0234"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0234"/>
    <dbReference type="eggNOG" id="arCOG04306">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088484_0_0_2"/>
    <dbReference type="OMA" id="WMASERI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="215" mass="24108" checksum="251F4E96A501522E" modified="2013-03-06" version="1">MQGKAAMRSSESIAADILQQLGYKIVDMHRKVVINNIEISDVDIIAEKNGMKYAVEVKAGPADVSSIRQIYVNSKLLNMIPMIISRGLADEKAEELAKELNVYFISLSDQVITNLDEIYASVKEALVDFLSDFFKFVTKCDMMSENEVKLVYSIAVSEDIIEASKNFGMPLEDFTKLISNLHNKGFLPSGKYEYISLVSKLMLIFCNIKSKINAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8A6</accession>
    <name>L0A8A6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231969.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70071">
        <property type="protein sequence ID" value="AFZ70071"/>
        <property type="gene ID" value="Calag_0291"/>
    </dbReference>
    <dbReference type="GeneID" id="14211551"/>
    <dbReference type="KEGG" id="clg:Calag_0291"/>
    <dbReference type="eggNOG" id="arCOG08352">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_999653_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="278" mass="32399" checksum="FC743A5EA59A1E3C" modified="2013-03-06" version="1">MKIELKDSKIFIDEKECCKINIEEKEINVIGNPEYNFVIKLGFRGYKIYQDNILVGKGKGLILSYKSETLKPDKKSELLTLDLMYGNDIVILDKYNSSVGTLRLDNGKLIANFDFHYLTFGIIYLSYLFGAMNNTINAMPKNNFEKPLLSIRTSKSYMKISLLLFAILFIIVVFISYFSIILAYIVALFLLMVPLISRVFSANNFINFYNDHLEIINDLSNRKLIIYYSDINEIKNYKKGFLIYLSNPILEKKEIFIQYNPKINNMPLSEFLRKKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8G5</accession>
    <name>L0A8G5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pantoate kinase</fullName>
            <shortName evidence="1">PoK</shortName>
            <ecNumber evidence="1">2.7.1.169</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28246"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. PoK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.169" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232009.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0334"/>
    <dbReference type="EnsemblBacteria" id="AFZ70111">
        <property type="protein sequence ID" value="AFZ70111"/>
        <property type="gene ID" value="Calag_0334"/>
    </dbReference>
    <dbReference type="GeneID" id="14211594"/>
    <dbReference type="KEGG" id="clg:Calag_0334"/>
    <dbReference type="eggNOG" id="arCOG04263">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081191_1_0_2"/>
    <dbReference type="OMA" id="KSALIIW"/>
    <dbReference type="OrthoDB" id="104702at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02223">
        <property type="entry name" value="Pantoate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012043">
        <property type="entry name" value="PoK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42282">
        <property type="entry name" value="PTHR42282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016896">
        <property type="entry name" value="GHMP_arc_MJ0969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="277" mass="30786" checksum="5FF681D1F95F9901" modified="2013-03-06" version="1">MVFCASVPYHITALFIPKIKEDPIYSGSIGIGIAIEPRLKLCVGEEIDNNGILPLTAKNVLDKLNIHENFNLNMPLPIKIGYASSASSTIAAELIGFLYGKTSYIKALQEAHKIEIENKTGLGDVLAISCGIGIILRKKEGAPGIGDVDCISFPKDISIVTLEFGSMETKELLNSYDSKILNESQRVLNKIEENFTFETVLYEIKDFSEKTKMINLLNHNDEILKTPGLLSYYIKKKMIVLLIENNKIEDALHKLKGIGLNLRILRPSSHGPEAWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8I7</accession>
    <name>L0A8I7_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L39e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl39e</name>
        <name evidence="5" type="ordered locus">Calag_0409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232076.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0409"/>
    <dbReference type="EnsemblBacteria" id="AFZ70178">
        <property type="protein sequence ID" value="AFZ70178"/>
        <property type="gene ID" value="Calag_0409"/>
    </dbReference>
    <dbReference type="GeneID" id="14211669"/>
    <dbReference type="KEGG" id="clg:Calag_0409"/>
    <dbReference type="eggNOG" id="arCOG04177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181948_4_0_2"/>
    <dbReference type="OMA" id="KMRYWRR"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_L39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_L39e_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="SSF48662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="51" mass="5972" checksum="912020391E54F27C" modified="2013-03-06" version="1">MARNKHLARKLRLAKAGKSNESVPVWVVVKTVRKFTRNPKSRNWRTSKLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8L4</accession>
    <name>L0A8L4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L15e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl15e</name>
        <name evidence="7" type="ordered locus">Calag_0401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232069.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0401"/>
    <dbReference type="EnsemblBacteria" id="AFZ70171">
        <property type="protein sequence ID" value="AFZ70171"/>
        <property type="gene ID" value="Calag_0401"/>
    </dbReference>
    <dbReference type="GeneID" id="14211661"/>
    <dbReference type="KEGG" id="clg:Calag_0401"/>
    <dbReference type="eggNOG" id="arCOG04209">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080796_1_0_2"/>
    <dbReference type="OMA" id="KYMQELY"/>
    <dbReference type="OrthoDB" id="85023at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00256">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_L15e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020926">
        <property type="entry name" value="Ribosomal_L15e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="PTHR11847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="216" mass="25423" checksum="877B154CCCC9005D" modified="2013-03-06" version="1">MSKSMYHYIASAWKKPYENEHVALMRERLIKWRSEPTIVRVEKPTRLNRAREIGYKAKQGVIVVRVKVRKGGMRKQRPISGRRPKRMGVNAITLRKSLRLIAEERAQNRYPDLVVLGSYYVGEDGTHKWYEVILIDPSNPSIRNDKDYSWILNSPSRSGRPNRGLTHAGKKMRGLTKNRGLTNTHNHKWSKKEKERKLKKGHEASKYIRYFNTREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8L8</accession>
    <name>L0A8L8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation initiation factor 6</fullName>
            <shortName evidence="3">aIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eif6</name>
        <name evidence="4" type="ordered locus">Calag_0407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232074.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0407"/>
    <dbReference type="EnsemblBacteria" id="AFZ70176">
        <property type="protein sequence ID" value="AFZ70176"/>
        <property type="gene ID" value="Calag_0407"/>
    </dbReference>
    <dbReference type="GeneID" id="14211667"/>
    <dbReference type="KEGG" id="clg:Calag_0407"/>
    <dbReference type="eggNOG" id="arCOG04176">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071894_1_0_2"/>
    <dbReference type="OMA" id="GEDTTGP"/>
    <dbReference type="OrthoDB" id="70525at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="PTHR10784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="224" mass="24306" checksum="B2B41E38548EE5BA" modified="2013-03-06" version="1">MPFEIVKMSIFGNSNIGVYIYGNDKITFVPQGLQKKDLDGISQILQTDIMETSLANTKLLGVLMAGNNNGIILSRSALDDEVDIIKKSIKDLNLYVLPSRNNAVGNLIVANDKAALVYPYFEDDVIKQIQDTLGVEVFRRSIVGIPTVGAIIAVTNVGGLVHPDVTDEEIKFLEDIFKVPFKTGTVNFGVSFIKTGLIVNTKGAIVGEDTTGPEIARIQMVFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8N0</accession>
    <name>L0A8N0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232089.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0422"/>
    <dbReference type="EnsemblBacteria" id="AFZ70191">
        <property type="protein sequence ID" value="AFZ70191"/>
        <property type="gene ID" value="Calag_0422"/>
    </dbReference>
    <dbReference type="GeneID" id="14211682"/>
    <dbReference type="KEGG" id="clg:Calag_0422"/>
    <dbReference type="eggNOG" id="arCOG04059">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2730123_0_0_2"/>
    <dbReference type="OMA" id="WEEAYEF"/>
    <dbReference type="OrthoDB" id="118172at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="71" mass="8334" checksum="1A7526226554AD8B" modified="2013-03-06" version="1">MSSENIIKVGGKQIEINDEVLLKVRKYVNTEMNLDELSKELGLDGWEEAYEFIKKIPAWMLRKYSKSLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Q9</accession>
    <name>L0A8Q9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232124.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0459"/>
    <dbReference type="EnsemblBacteria" id="AFZ70226">
        <property type="protein sequence ID" value="AFZ70226"/>
        <property type="gene ID" value="Calag_0459"/>
    </dbReference>
    <dbReference type="GeneID" id="14211719"/>
    <dbReference type="KEGG" id="clg:Calag_0459"/>
    <dbReference type="eggNOG" id="arCOG04311">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039453_4_2_2"/>
    <dbReference type="OrthoDB" id="96549at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="6">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="176" mass="19739" checksum="C05D02A12113806B" modified="2013-03-06" version="1">MSKIDELIYSLNSIARSGWMIKGIEPCKAETVSQHLFASSLIALEISSKLNNVDKYKAASIALIHDIGEAIIGDISKTANIDKSKSEKDAINSLDINNEIKKLYYEFESSNTIEGIIAKISDLLSTYIISLKYEREGYNVNSIKDNVKEEIINLSKKYNLENIIIDFLKGLDKTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Y6</accession>
    <name>L0A8Y6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232246.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0591"/>
    <dbReference type="EnsemblBacteria" id="AFZ70348">
        <property type="protein sequence ID" value="AFZ70348"/>
        <property type="gene ID" value="Calag_0591"/>
    </dbReference>
    <dbReference type="GeneID" id="14211851"/>
    <dbReference type="KEGG" id="clg:Calag_0591"/>
    <dbReference type="eggNOG" id="arCOG04215">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061573_1_0_2"/>
    <dbReference type="OMA" id="FQRDWCL"/>
    <dbReference type="OrthoDB" id="99390at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038764">
        <property type="entry name" value="GNAT_N_AcTrfase_prd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41700">
        <property type="entry name" value="PTHR41700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="297" mass="34240" checksum="A866FD3BC7804D47" modified="2013-03-06" version="1">MEDILIKKIKDAKDLENVMEIEKSAWGMPDYTEATPVHILKALAENGGIILGAFYNGNMIGFNMGWAVGCNENRYFYSHMTGVLNEYKYKNVGYKLKIKQREEVLKLGIDLIKWTFDPLQSLNLNFNLEKLGAIGRIYKENYYGNIRDSINKGLETDRFEAEWYISSKYVSNKLEGKIKTPSFEELMGKGAYLAIDSKTSKEKGKKGEIFDIEIPIKKEFKLNNKIVLISIPKEISFIKEINKDIAQMWRLYTREAYKFYLSNGYIAIGYTKSKNNGYVVLIKTSLNDLLEGDKLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Z7</accession>
    <name>L0A8Z7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NurA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232261.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0606"/>
    <dbReference type="EnsemblBacteria" id="AFZ70363">
        <property type="protein sequence ID" value="AFZ70363"/>
        <property type="gene ID" value="Calag_0606"/>
    </dbReference>
    <dbReference type="GeneID" id="14211866"/>
    <dbReference type="KEGG" id="clg:Calag_0606"/>
    <dbReference type="eggNOG" id="arCOG00367">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_684437_0_0_2"/>
    <dbReference type="OMA" id="RSTEICR"/>
    <dbReference type="OrthoDB" id="45596at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="43"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="385" mass="43961" checksum="EB1A5810B3602F56" modified="2013-03-06" version="1">MDSTLINSTLKNKDIILDIIKKNPKSQCNIKWNPLPEKVDYDIEVSAEDGGDMISEFDTFTLYVVKSWAKTFNNNLKPIENALIGLLLPPKYTMLRVSLYREIIEAKSSLNAIPKNGIAFFDGSLTPLIAWWRPSASIKNGEELDILLEEADNELKNGGYFINKIDDLLNESLYHPLIPLMLMDKEQKDQLKPMIDAFLAMEILEKLYLYKILLEKIFENNSLPIFISKTSRSTRLCNSNLPDVHIIKKMVRSEPGYVYWDGSLNMGASNIIGEKNMKKMFPKLGGIEDFYENRLGMVRFYARFQHGAPILQVEALFDQNKGIPDTEDFINQVISKIILIPLQQGYPTSLVFAHKNAEITHDDMEALIKVAGIEGELKERSMLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A900</accession>
    <name>L0A900_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative AP superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231802.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0116"/>
    <dbReference type="EnsemblBacteria" id="AFZ69904">
        <property type="protein sequence ID" value="AFZ69904"/>
        <property type="gene ID" value="Calag_0116"/>
    </dbReference>
    <dbReference type="GeneID" id="14211376"/>
    <dbReference type="KEGG" id="clg:Calag_0116"/>
    <dbReference type="eggNOG" id="arCOG01378">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039939_1_0_2"/>
    <dbReference type="OMA" id="LMNQLRW"/>
    <dbReference type="OrthoDB" id="12142at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="381" mass="44248" checksum="D4E2D271D3B84C1A" modified="2013-03-06" version="1">MELDLEYPDYDNNMTIYGLSCGLAKFFDVKRNCMVNPIAFQGNKLVFIFIDGLGWELFNRLNIEIKGEVNKIKTVFPSTTSTVTTTLFTGQTPGEHGVLGYIMFNKKLGGIINTLRYNYVGEPINDSIKQYMGFIKAFPVKPWIHETNKKILTIIQNSISNTEFTNTLHRDLNRPDISYLVGYFNSTDMIINLIKSLSSNQYDGIFVYYDAVDHLGHSYGYNNEFHDFILYDAKYVLENLINVAYKFRDKYTFVLFADHGQITVKKTVVWNNDKELLDMLEVPPYGDSRAIWFRSRYNIKKYLEDKYNLLVFDKNEIIDSKLLGKVENEVMNNYMGDYLGISKDNETKYLYTYRENDPGLNLKGNHSGLTKEEMYVPLIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A910</accession>
    <name>L0A910_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mut7-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232249.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0594"/>
    <dbReference type="EnsemblBacteria" id="AFZ70351">
        <property type="protein sequence ID" value="AFZ70351"/>
        <property type="gene ID" value="Calag_0594"/>
    </dbReference>
    <dbReference type="GeneID" id="14211854"/>
    <dbReference type="KEGG" id="clg:Calag_0594"/>
    <dbReference type="eggNOG" id="arCOG04290">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112469_1_0_2"/>
    <dbReference type="OMA" id="CGQIYWP"/>
    <dbReference type="OrthoDB" id="96038at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="168" mass="19605" checksum="C4294F340BC32EB4" modified="2013-03-06" version="1">MSKYIADAMLGTLTRWLRILGYDIIYSRDYSDGQIINIALKTKRMIITRDRGLYHKAKKLNIDSYLIESTDIVKILSELYSKKIIELELDPAKSRCPQCNEKLIKVTDKNLIRNRVPPGALKTYNTFYLCKKCGQVYWEGGHWKNIRRIINEAKINSINSSEPKENFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A919</accession>
    <name>L0A919_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA repair exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232259.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0604"/>
    <dbReference type="EnsemblBacteria" id="AFZ70361">
        <property type="protein sequence ID" value="AFZ70361"/>
        <property type="gene ID" value="Calag_0604"/>
    </dbReference>
    <dbReference type="GeneID" id="14211864"/>
    <dbReference type="KEGG" id="clg:Calag_0604"/>
    <dbReference type="eggNOG" id="arCOG00397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026621_5_2_2"/>
    <dbReference type="OMA" id="YRQYNLD"/>
    <dbReference type="OrthoDB" id="25870at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="408" mass="46740" checksum="5C9A36A986DD0D16" modified="2013-03-06" version="1">MQIVHMSDLHVGAKPRNEKIIYNDIIDAFNESMDLIIREKPNLLIIAGDLFDTPKPDNDSLKIVINRFKEVTNHDIPIILAHGEHDTPGRKESTILQVLSSAISNVYAPLYESKGNEDENTMFLNIVKESKISTKNIDIYVYPYKKINLDMRKNLADKLLKIYDKEIRSNGNKSVFVAHFSIDPYLLFDAVADVQKLPNANYIALGHIHERIINKKDKFFVYPGSLYPLSISEIKHKNRGPILVDLSKDEPDIQELKINLRDNLFARISIEDEKDIINKLRAGIEVKIRETLNKNKQPIVYLDIEKSKDIYARSIIQAITKIENEFNVHIIPEMKNKEKKESSYSVKALSRSGLDPFNILVNELKLGDNTAKLLLDLRDATLEGDESKIVEVLDKLSKESLDELKRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A927</accession>
    <name>L0A927_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MYM-type Zinc finger with FCS sequence motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0615"/>
    <dbReference type="EnsemblBacteria" id="AFZ70371">
        <property type="protein sequence ID" value="AFZ70371"/>
        <property type="gene ID" value="Calag_0615"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0615"/>
    <dbReference type="eggNOG" id="arCOG08078">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209487_0_0_2"/>
    <dbReference type="OMA" id="RCENCGM"/>
    <dbReference type="OrthoDB" id="124023at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013603">
        <property type="entry name" value="TRASH_TR_C_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08394">
        <property type="entry name" value="Arc_trans_TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="1">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="53" mass="6052" checksum="381DA7133C525ED0" modified="2013-03-06" version="1">MNLRINDIEGKVCESCGKPLTVEDVYARKIGNEIHYFCCSHCADAFERKMKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A933</accession>
    <name>L0A933_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein archease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232301.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0652"/>
    <dbReference type="EnsemblBacteria" id="AFZ70403">
        <property type="protein sequence ID" value="AFZ70403"/>
        <property type="gene ID" value="Calag_0652"/>
    </dbReference>
    <dbReference type="GeneID" id="14211912"/>
    <dbReference type="KEGG" id="clg:Calag_0652"/>
    <dbReference type="eggNOG" id="arCOG04055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111362_3_0_2"/>
    <dbReference type="OMA" id="WLSELLY"/>
    <dbReference type="OrthoDB" id="125788at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01222">
        <property type="entry name" value="Archease_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022952">
        <property type="entry name" value="Archease_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="PTHR12682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="7">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="143" mass="16779" checksum="20A9FF09EE06FB5B" modified="2013-03-06" version="1">MLNKCPGYEFLDHTSDVLIKAIGNSLNESFEQAAIAVYEVITDTNKVMPLNEIEIEVDGYDIYNLLYRWIESLLYYTDSEGLVFSKFVVNIDEKNTRLKAKIYGEKFNNEIHEHRTIVKAMTYSQMEIKKEENCWVIYFVVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0A976</accession>
    <name>L0A976_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232324.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70426">
        <property type="protein sequence ID" value="AFZ70426"/>
        <property type="gene ID" value="Calag_0677"/>
    </dbReference>
    <dbReference type="GeneID" id="14211937"/>
    <dbReference type="KEGG" id="clg:Calag_0677"/>
    <dbReference type="HOGENOM" id="CLU_2765828_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="69" mass="7913" checksum="EA812043002B36D1" modified="2013-03-06" version="1">MKIVIKIIIILSITIVAISSLYLTYNISKPIIREVNVSGEVHICKDPTFITFYNNKSIYTARVVNTRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A992</accession>
    <name>L0A992_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kef-type K+ transport system, membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0696</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232339.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0696"/>
    <dbReference type="EnsemblBacteria" id="AFZ70441">
        <property type="protein sequence ID" value="AFZ70441"/>
        <property type="gene ID" value="Calag_0696"/>
    </dbReference>
    <dbReference type="GeneID" id="14211956"/>
    <dbReference type="KEGG" id="clg:Calag_0696"/>
    <dbReference type="eggNOG" id="arCOG01953">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_2"/>
    <dbReference type="OMA" id="TTFSHEG"/>
    <dbReference type="OrthoDB" id="79669at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="14"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="391" mass="42020" checksum="637DDDCED8573091" modified="2013-03-06" version="1">MLSEVILALLEISLLVLFAALMGSVAIRFKFPKVVGDLLIGIILSPFLIGGFINKIIDVNLFSINNYLLLFSEFSVILLIYSIGLESGVSALRSSGISGIMGAIFGATIPFIFGAILIRFFVSFSAALIIGSALGATSLAVASSLIKETNLKGNGVNFILTAGSFDDVVSLIILSVAIAMSTLKTISYADILRTIFFYGIAWFIIFATSVFIIPKIFNNIIKEKYVFEGSLVIIFALTAIMTTLGFSPIIAAYIAGVAMAESNKAAKLRENTNALLALFGSIFFVTMGAQVNLIKLSYFGLIFSLFITAIAIIFKILGIYPFSYLATRSHKSSLAISIGMIPRGEIGLAVANIGLTYSIINDVEFSSIVIMSLLTTILGALIFGKIYHYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0A998</accession>
    <name>L0A998_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uracil phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0728"/>
    <dbReference type="EnsemblBacteria" id="AFZ70473">
        <property type="protein sequence ID" value="AFZ70473"/>
        <property type="gene ID" value="Calag_0728"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0728"/>
    <dbReference type="eggNOG" id="arCOG04128">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_0_2"/>
    <dbReference type="OMA" id="TYATRMP"/>
    <dbReference type="OrthoDB" id="85528at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="217" mass="24386" checksum="7D75C5026195F5FA" modified="2013-03-06" version="1">MYNLAKIKVLGEELPIARYLLKKLRDKNTSLSEFRKAMSNAGKILAIESSRELMWRQEKVITPLNQEAVELELINQPLLVGILGAALPLMEGFIDIYPDAPIGLVAAKRNEIYGSINIDIYYKRLPERYDEIAYLIDPMLATGKTMDKVIDELYKRGIKKIIIASVISSKPGINYLLSLYDNLVIYSLSIDNNLDDNFFIIPGLGDAGDRGLGIEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A999</accession>
    <name>L0A999_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0217</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0217"/>
    <dbReference type="EnsemblBacteria" id="AFZ69999">
        <property type="protein sequence ID" value="AFZ69999"/>
        <property type="gene ID" value="Calag_0217"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0217"/>
    <dbReference type="eggNOG" id="arCOG00932">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053467_0_0_2"/>
    <dbReference type="OMA" id="DCFYCPL"/>
    <dbReference type="OrthoDB" id="85003at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040087">
        <property type="entry name" value="MJ0021-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43288:SF1">
        <property type="entry name" value="PTHR43288:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01108">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="26"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="332" mass="37790" checksum="04ACED6AA7A27BDE" modified="2013-03-06" version="1">MLKKNNIMGSDKIGLTIGRMEKGCELCFPGLKSVIFITGICGDSCYYCPVGKDRFGHDVIYVNEERITNLRDMIIEIERQGAIGASITGGDPLVVFPRTIKIIKMLKKHFGNEFHIHLYTSGRYATPDALVSLYKAGLDEIRFHPVKDEYKIAISYASKLTKMRVGAEIPIAKGLENWAIDIIKTVEKYGGSFVNLDEMEFVEPNARALISMGLNEDKNRPFTAKGSLEAALKVLEWARENSNIYVHFCPASFKDAIQTKNRFTRLSRNDKKWYEEITKDGTIKWAEVNINGNIIKINPNDIYNYKGYEIKILESHPTRDRKPIINEEIIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9B4</accession>
    <name>L0A9B4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane-associated Zn-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231912.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0232"/>
    <dbReference type="EnsemblBacteria" id="AFZ70014">
        <property type="protein sequence ID" value="AFZ70014"/>
        <property type="gene ID" value="Calag_0232"/>
    </dbReference>
    <dbReference type="GeneID" id="14211492"/>
    <dbReference type="KEGG" id="clg:Calag_0232"/>
    <dbReference type="eggNOG" id="arCOG04064">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042134_0_0_2"/>
    <dbReference type="OMA" id="TIPLWYG"/>
    <dbReference type="OrthoDB" id="94875at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PTHR13325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="6">
        <location>
            <begin position="114"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="373" mass="40645" checksum="C5945572BACE19AC" modified="2013-03-06" version="1">MQSWLLILIAFIIFWGILYIIGKSFKSKKINIYPLVLIARTGISMEPIKDKKKAKVISIFGYISLAISIGLMAYFYYIVGSTFVAKYIAQSSSQVAGFVPLIPGVTISIDQLIYFLIAIGIAVIVHELFHAIIARAEGIPVKDAGFFLLAFIPAAFVEPDDNKMKQAPLKSRLKVYSAGVTINLIMGLIFLLLFVYIAPKLFAGVDLVNILPNSPAYLANLKQGMTILSVNGTSTLSLQSFMNVLNKYGAESNNTAVNLLLTVKYNGVIQNISVFKPYGVPHLGISVVQSFRLSWLVSIISALYIINLGLALVNAAPIAIPLPGGMIQSDGGYIFIEAISKIGKKWAQAGITIEIITVLLILSLLTIYPIRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9K2</accession>
    <name>L0A9K2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase, class IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232475.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0837"/>
    <dbReference type="EnsemblBacteria" id="AFZ70578">
        <property type="protein sequence ID" value="AFZ70578"/>
        <property type="gene ID" value="Calag_0837"/>
    </dbReference>
    <dbReference type="GeneID" id="14212097"/>
    <dbReference type="KEGG" id="clg:Calag_0837"/>
    <dbReference type="eggNOG" id="arCOG00984">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_2"/>
    <dbReference type="OMA" id="HAMSHQV"/>
    <dbReference type="OrthoDB" id="22099at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="7"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="387" mass="43136" checksum="BCE03122C65D3094" modified="2013-03-06" version="1">MVIFSMPRRIAYNVNASEELLNLSTMLNLKNFLIVTDKIIEKTDSFVSLVNELTKNGINIKVYSEIIPEPNIDIVNKIIESMGGYVPDLIVSIGGGSVIDVSKILRAKILRPDINSQDISPFLSLNIENKKPLLVVIPTTSGTGSDASFAYVLKIKENNNEIKYASGNYELVPYESILDITFLKTLPKKQLIITAIDGLANDLEGIVAINSNPLTEGLAIQSARMFFKYLPDAVMTRSDESLANLHLAATLSGIAFSNSGVGLVHAIAHPLGSLFDIPHGMAVSIIMPYVIEYNYKSDFARSKYDEIKIVLEKIDGFQERNNLKDHLIDLYNKIGQPLRLRDIGIDKNNYMRKIEEITELALRDPDLAFNPITPSFEEIKELLSKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9K5</accession>
    <name>L0A9K5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TIM-barrel fold metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0810"/>
    <dbReference type="EnsemblBacteria" id="AFZ70551">
        <property type="protein sequence ID" value="AFZ70551"/>
        <property type="gene ID" value="Calag_0810"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0810"/>
    <dbReference type="eggNOG" id="arCOG01931">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_827942_0_0_2"/>
    <dbReference type="OMA" id="DPGIWEL"/>
    <dbReference type="OrthoDB" id="112345at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="134"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="335" mass="37826" checksum="29B07EBB8E8B788E" modified="2013-03-06" version="1">MKNKIWVVYLKADIPVSCIIDAHVHSPVMKNAKDVNEYLRKLIDSGIGGAVILGIPPFKDLLLKVSYDDILTEYERTKYLIEKFAEEVKDFLTPENLFIMAHQISESFCHFIKHQEISALSNFTVLFPANLSLEPDVLSTILERSLNEGFKGFKIISTLFFKHLDDPSVEATIEVANEKGLPVTIHGGCDPGIWELPKFCKYGDPSKLDRILNKYKDAKIIIAHAGGYSAIAPGVFIDETLELVKKYPNVYIDTSALPVQLIPIVMKMFPRDRIMYGSDYPAVSNANPRNYMEDVFLTLLSSGISKRDLEKFAHENAESIFDIECLSQNYDLINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9L6</accession>
    <name>L0A9L6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Archaeal DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232463.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0825"/>
    <dbReference type="EnsemblBacteria" id="AFZ70566">
        <property type="protein sequence ID" value="AFZ70566"/>
        <property type="gene ID" value="Calag_0825"/>
    </dbReference>
    <dbReference type="GeneID" id="14212085"/>
    <dbReference type="KEGG" id="clg:Calag_0825"/>
    <dbReference type="eggNOG" id="arCOG01753">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110989_2_1_2"/>
    <dbReference type="OMA" id="FKQVELY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="87" mass="9473" checksum="28572563297458C1" modified="2013-03-06" version="1">MEERVKINLGKEAIEDYALQAILELNKGTKQVEITGVGENVCKVAEVYLAMKSRLGDSLKIVSSLIGTSKTKGKKSSYLTIVIEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9P2</accession>
    <name>L0A9P2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0863"/>
    <dbReference type="EnsemblBacteria" id="AFZ70603">
        <property type="protein sequence ID" value="AFZ70603"/>
        <property type="gene ID" value="Calag_0863"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0863"/>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029940_0_0_2"/>
    <dbReference type="OMA" id="HLLLMHE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="64"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="295" mass="34697" checksum="83D387E8E35BFAA5" modified="2013-03-06" version="1">MNSLVYERDFIGYGENHLDFKWPGNKRLAVNLVFNYECGSEHSYNVDGIVESVGEFPPIDIKERDVGLESVYEYGTRVAIWRILKVLNDYNVKASFFAVAHTLELNPIAAKAIVNQGHEIVDHGLRWFENYRLSYDEEKRQIEKSVEIIEKITGYKPKGFYAREPSVNTIDIVKDLGFMYDSDAYNDDLPYYYKGFLIIPYTPDVNDFHFLYPMNRFSTAEEFFSYAKDAFDQLYEESKYEPKMMSIGMHVRIIGRPGRIKALKDFLNYIKSFDVWIAKREEIAEFWLNNFKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Q3</accession>
    <name>L0A9Q3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na+/proline symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231775.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0088"/>
    <dbReference type="EnsemblBacteria" id="AFZ69877">
        <property type="protein sequence ID" value="AFZ69877"/>
        <property type="gene ID" value="Calag_0088"/>
    </dbReference>
    <dbReference type="GeneID" id="14211348"/>
    <dbReference type="KEGG" id="clg:Calag_0088"/>
    <dbReference type="eggNOG" id="arCOG01316">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_15_0_2"/>
    <dbReference type="OrthoDB" id="8968at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ69877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="496" mass="54396" checksum="F7E863A2B44992DD" modified="2013-03-06" version="1" precursor="true">MITASGLQMLITFIVLFIAFAIVGFLGSRFRRADLTQLHEWGLGGRRLGTAFQFFLQGADWFTAYSILAIPSAVFALGAYGFFGVAYQAMVFTWASVFMPRLWRLSKNKGYITIADYARGEFNSILLSLSVVVLGIFATLFYIALQVDGLYAILGTMFLESFGISPVSAAFKEYSVLILFIAFVVIAAFSFTSGVRGVSLGAVFKDILVWLGLLTVIVATLYYTHGFNNIFSGMPSKYVALPSVQALAFSTSMLGVVFSAYLWPHNVTGSWAAQNEERLLKGYSLTILYAIPLALADIMAIAVYKIPSVHSFVFQFPASSRGLYVIPGLLVSLVPSWLTGIALLGIFVGGLVPAALMAVTVGNMVGRDLSRMIKPNISGKGQTQIAKWSAVGFTLLSLALLQVIPMTYAFQFYLIGAEIILQFLPIAVIHPFIKFIRKEFAIAGIWIGTIVSIYTTLYANHFKVISTTLYHDIYIGFIGLFINIIIVLFSLAFPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9R7</accession>
    <name>L0A9R7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232057.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70159">
        <property type="protein sequence ID" value="AFZ70159"/>
        <property type="gene ID" value="Calag_0386"/>
    </dbReference>
    <dbReference type="GeneID" id="14211646"/>
    <dbReference type="KEGG" id="clg:Calag_0386"/>
    <dbReference type="eggNOG" id="arCOG01009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202919_0_0_2"/>
    <dbReference type="OMA" id="LINAMDQ"/>
    <dbReference type="OrthoDB" id="130007at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="70" mass="8227" checksum="EE12705BA0137FE0" modified="2013-03-06" version="1">MKLITVKMPDLYVKGIDELVKAERYSSRSEVIRIAIRELLKRELWGEMPNEENNLLFNFNQSGIESLNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9S5</accession>
    <name>L0A9S5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar pyrophosphorylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232540.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0905"/>
    <dbReference type="EnsemblBacteria" id="AFZ70643">
        <property type="protein sequence ID" value="AFZ70643"/>
        <property type="gene ID" value="Calag_0905"/>
    </dbReference>
    <dbReference type="GeneID" id="14212165"/>
    <dbReference type="KEGG" id="clg:Calag_0905"/>
    <dbReference type="eggNOG" id="arCOG00666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_1_2"/>
    <dbReference type="OMA" id="GEGQWIF"/>
    <dbReference type="OrthoDB" id="61185at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="383" mass="41555" checksum="E7A7844667750AE7" modified="2013-03-06" version="1">MIGVVLAGGYGKRLLPLTKEKPKSFLEIGGKQLLDYSVEILRNAGIRKIVVIVPPGYENMAIPRDEDVYIVGQKGEDIRGGIYTAVLEAKKRNEDQVMIAYSGFLASPGIGKAVIDYYASSGYPIVIGVSSVSTGLETYGFVTIDYRGQITSYNQADEKTRTWLKNRGYVFAGLIVSDVNQLERLSKDQFESAMAMVSKEGIVGGIIWNNKWIEVGYPWDLLDALKIILNTSGIKINNTANVSRSAIISNGVVIDDYATIEEGAIIIGPAYIGRRAQILAGSIIKPYTSIEENAVIGENTIVSNSLIMKDAYVGALSEIRNSVIGEGAKIEESSHLIEGTPEMLPDRLKGITEFLGEVKLGAIIAPKERINPFTVIGSGKVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9T5</accession>
    <name>L0A9T5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydro-lyase family enzyme, Fe-S type, tartrate/fumarate subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232508.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0871"/>
    <dbReference type="EnsemblBacteria" id="AFZ70611">
        <property type="protein sequence ID" value="AFZ70611"/>
        <property type="gene ID" value="Calag_0871"/>
    </dbReference>
    <dbReference type="GeneID" id="14212131"/>
    <dbReference type="KEGG" id="clg:Calag_0871"/>
    <dbReference type="eggNOG" id="arCOG04406">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098588_0_0_2"/>
    <dbReference type="OMA" id="IYHCGPL"/>
    <dbReference type="OrthoDB" id="88282at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase_C" evidence="4">
        <location>
            <begin position="6"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="205" mass="23095" checksum="F1354365B1327C0D" modified="2013-03-06" version="1">MVNEYHLKTPLSDDIINKLNIGDIVYISGIMVTARDEAHEMALELLDKGEKLPLDLKGLVLYHCGPVAIKKDNKWSIVAAGPTTSMRMESVEYKFIEKTGIKMVVGKGGMGKKTADAMKKYNAVYAVFTGGAGALAAERIKEVKDVYWLDKLGIPEAMWVFRVEEFGPLIITIDNKGNNYYERRLKEVANNAEKIKDELMQYKWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9V4</accession>
    <name>L0A9V4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dinucleotide-utilizing enzyme possibly involved in molybdopterin or thiamin biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232528.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0891"/>
    <dbReference type="EnsemblBacteria" id="AFZ70631">
        <property type="protein sequence ID" value="AFZ70631"/>
        <property type="gene ID" value="Calag_0891"/>
    </dbReference>
    <dbReference type="GeneID" id="14212151"/>
    <dbReference type="KEGG" id="clg:Calag_0891"/>
    <dbReference type="eggNOG" id="arCOG01676">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_10_1_2"/>
    <dbReference type="OMA" id="SAKWKLE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="10"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="343" mass="38898" checksum="EA176EB5D9DF3A8C" modified="2013-03-06" version="1">MIDKNILSRFSRQILMQDIGYEGMEKIRNSKIAIVGCGALGSTQGEILARAGVGKIKLIDRDYIDLSNLHRTHMAKEEDALNSLPKAIVCEKGIKEIDNDIEVETLIDDFDSTNAEEFLKDVDLIIDGTDNLDARFLINDVSVKNNIPWIYAGVNSWYGNVMFIKPNVGPCLRCLIPENNNENQSCDIIPSIGTMTSLVSSFSSNLAIRYLAGNEVPYGVLFVIDGRDFSIEKIKIEKNDKCPTCGFHYYEFLNKKEKRGAERICGTHAIEIRPERFLSIDFYKNVEKIKRKYDVITINKYSIRIQRNAIQIILMNNGLAIVENEDDLKKAKELYDDVIKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9X7</accession>
    <name>L0A9X7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232553.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0925"/>
    <dbReference type="EnsemblBacteria" id="AFZ70656">
        <property type="protein sequence ID" value="AFZ70656"/>
        <property type="gene ID" value="Calag_0925"/>
    </dbReference>
    <dbReference type="GeneID" id="14212185"/>
    <dbReference type="KEGG" id="clg:Calag_0925"/>
    <dbReference type="eggNOG" id="arCOG01411">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_907935_0_0_2"/>
    <dbReference type="OMA" id="TRGEKNV"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="306" mass="35166" checksum="429AEBF57819200E" modified="2013-03-06" version="1">MLISNIISKDPIRFGKEIFSVNLEKARFYSFGKFNNKTSDILSWYYKGSKAVKNYDVVILNGIVPISHKRKVGIIHHLSPNLKSMKFLIYKFLYNNNKINVCVSNKVRYEAVKKGINCDHVVNPPIKSELFSINNCKDKNEKFILHTGADYRKHPEVSYEAVKILNEKFNLQIKLKIVLNWPIDKTFSDIETKCCISLKELLDLYCNSYLLLAPYEYEGFAYTIAEAQNFVPVIAGPGIPDDAYIDGLTGIKVNTLDPLDYANEIYNLIKNEKLYNLMKANAMIFSKRFDIDNIGEKFESILNSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Z0</accession>
    <name>L0A9Z0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acetamidase/formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231850.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0167"/>
    <dbReference type="EnsemblBacteria" id="AFZ69952">
        <property type="protein sequence ID" value="AFZ69952"/>
        <property type="gene ID" value="Calag_0167"/>
    </dbReference>
    <dbReference type="GeneID" id="14211427"/>
    <dbReference type="KEGG" id="clg:Calag_0167"/>
    <dbReference type="eggNOG" id="arCOG01004">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032013_1_0_2"/>
    <dbReference type="OMA" id="PWGFTGI"/>
    <dbReference type="OrthoDB" id="104958at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="PTHR31891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="309" mass="34609" checksum="6299D00C3BC60DE2" modified="2013-03-06" version="1">MIQIDGFMDSNVHFKWSNKLKPIAYVNSGDELLIKVPDSSTKQIKYDFKTEDLSKLDSSKFDGAVGPIYVYDAKPGDALEVEIQDIKVDKWGWSAILSDFGILKKRFNERLIIWDIKENYAIAKDFLRGIKIPIRPFLGVIGLSPKEDKEYDMIPPQYFGGNMDNRLNGIGSKIYLPVNVEGALLSISDPHASQGDGEICGTAIETSAEVKLKVKVIKDLKIKRPFTISPNKDDFKGEVIAAMGISSDLYQAAKDAVNDMIELLNRQYKLSYEEGYVLSSVIGNLRISEIVDEPNFVVSLVIPKYILES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Z5</accession>
    <name>L0A9Z5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acyl-CoA transferase/carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231855.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0172"/>
    <dbReference type="EnsemblBacteria" id="AFZ69957">
        <property type="protein sequence ID" value="AFZ69957"/>
        <property type="gene ID" value="Calag_0172"/>
    </dbReference>
    <dbReference type="GeneID" id="14211432"/>
    <dbReference type="KEGG" id="clg:Calag_0172"/>
    <dbReference type="eggNOG" id="arCOG02304">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_2_1_2"/>
    <dbReference type="OMA" id="LIVCNIS"/>
    <dbReference type="OrthoDB" id="20007at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="375" mass="42592" checksum="AF4F7E7EBAA32772" modified="2013-03-06" version="1">MRAIEIGHIVAGPTAGLLLSLLGFEVIKIEKPKEGDIARRLPGSSSGTFPYLNYNKKSISLDIFKEKGKEAFKRLIKTSDVLIDNLSRGTLQNAGLGYEELKKINPRLIYASIKAYGYGPYENRKSLDYPIEVHSGLAYMTGLNDRPMRLGASIVDIGAAMFAVIGIMQKILEREKTNEGGVVDIGLFETALFFVGQHISTYQILGKPIKPINEEGFAWGIYDFFKTKDDKSIFIAVTTDKQWIDFCNALSLDICNDDRFKRNEDRYKNRSFLIPYLNKIINSFNSYELIKLLDKSNISYSILNKPWDLLNDEHAKLKMINVLYQKREIVVPKPPFYTSIKSNVAPDLGENTYEILRELGYNEDEIKIMEIEGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA08</accession>
    <name>L0AA08_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-aminopeptidase/D-esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231865.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0183"/>
    <dbReference type="EnsemblBacteria" id="AFZ69967">
        <property type="protein sequence ID" value="AFZ69967"/>
        <property type="gene ID" value="Calag_0183"/>
    </dbReference>
    <dbReference type="GeneID" id="14211443"/>
    <dbReference type="KEGG" id="clg:Calag_0183"/>
    <dbReference type="eggNOG" id="arCOG07260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044458_1_0_2"/>
    <dbReference type="OMA" id="PHFWAAP"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="293" mass="31930" checksum="DEF07CB5B12D1DF8" modified="2013-03-06" version="1">MKIVDGFKICGYDDDNAKSGITAVFPMKENVASVYVAGGSPGTRDTEVIDLEKRKNHEVNAISIVGRSIYGLKAVEGIVDSLRKDNIGFKINNIIVPIVPSAVIFDFYYNNILPDETWGIKCYKNMSQDVKIGNYWAGKGATVGKLMGLEYMMKSGQGYYKEGFGKVEIGVLTVVNAIGEIINEKGEIIAGVNMNGKIIPSQEILKKKLMKNSSINTTVSIVMTNIKASVEEMKLIAKSAYLGISRRIRPIGLSLDGDVVFSVTTNEVEEDIDTIRGLVEDIASKSVLSIWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA20</accession>
    <name>L0AA20_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231875.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0195"/>
    <dbReference type="EnsemblBacteria" id="AFZ69977">
        <property type="protein sequence ID" value="AFZ69977"/>
        <property type="gene ID" value="Calag_0195"/>
    </dbReference>
    <dbReference type="GeneID" id="14211455"/>
    <dbReference type="KEGG" id="clg:Calag_0195"/>
    <dbReference type="eggNOG" id="arCOG00856">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_2"/>
    <dbReference type="OMA" id="TMTTIQL"/>
    <dbReference type="OrthoDB" id="13052at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="45"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="460"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="558" mass="64315" checksum="C34D5A10BB823D26" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA60</accession>
    <name>L0AA60_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Altronate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231833.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0149"/>
    <dbReference type="EnsemblBacteria" id="AFZ69935">
        <property type="protein sequence ID" value="AFZ69935"/>
        <property type="gene ID" value="Calag_0149"/>
    </dbReference>
    <dbReference type="GeneID" id="14211409"/>
    <dbReference type="KEGG" id="clg:Calag_0149"/>
    <dbReference type="eggNOG" id="arCOG05318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084161_3_0_2"/>
    <dbReference type="OMA" id="YTHDAGH"/>
    <dbReference type="OrthoDB" id="110381at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11613">
        <property type="entry name" value="SAF_AH_GD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044144">
        <property type="entry name" value="UxaA/GarD_SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="2">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="96" mass="10704" checksum="065BF9549A4C7DEC" modified="2013-03-06" version="1">MLRKADALALNENDNVAVSLRELNKNEKALVIRGNEKIEVEIIDKIPYGHKFSLFNIKKGDYIIKYGEIIGIATSDIPKGAHVHVHNVKGLRAGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA68</accession>
    <name>L0AA68_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70798">
        <property type="protein sequence ID" value="AFZ70798"/>
        <property type="gene ID" value="Calag_1076"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1076"/>
    <dbReference type="eggNOG" id="arCOG10150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193441_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="91" mass="10604" checksum="69884B248B5F4F4B" modified="2013-03-06" version="1">MRKLGCGRNFGWYPGNGPFNYLPPWERPGYYMRYGIQNVGFVPPFAYGISLSKEERISYLQTIKNNLEIAKTNIEKEIQDINNIIENLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA73</accession>
    <name>L0AA73_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232700.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1081"/>
    <dbReference type="EnsemblBacteria" id="AFZ70803">
        <property type="protein sequence ID" value="AFZ70803"/>
        <property type="gene ID" value="Calag_1081"/>
    </dbReference>
    <dbReference type="GeneID" id="14212341"/>
    <dbReference type="KEGG" id="clg:Calag_1081"/>
    <dbReference type="eggNOG" id="arCOG01214">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1173412_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="237" mass="27118" checksum="2F23E67B9F218269" modified="2013-03-06" version="1">MKLIMLDYDGTISPIDVSIDKAFPSNEILNAIRYSRKKGNIIAIVSTKVCDFLMNRVEADVYSCIAGAEILYENRSCIDTNLIKYQDDATTLINFIKNDKEIIRSNARIEVKKTTSNLIAGITIDWRNSSYPESIQKIIEQAEKMKLKVIKYKSEPFIDILVSNLNKGDAVIFLKRLFNPDLTIYFGDSENDLPAFEKTDIPILVLHQYNKHLKNVGVKEMVEFSEVSEAIRKYADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAC4</accession>
    <name>L0AAC4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-methylhydantoinase B/acetone carboxylase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232272.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0619"/>
    <dbReference type="EnsemblBacteria" id="AFZ70374">
        <property type="protein sequence ID" value="AFZ70374"/>
        <property type="gene ID" value="Calag_0619"/>
    </dbReference>
    <dbReference type="GeneID" id="14211879"/>
    <dbReference type="KEGG" id="clg:Calag_0619"/>
    <dbReference type="eggNOG" id="arCOG01512">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020413_0_0_2"/>
    <dbReference type="OMA" id="QVGMTNT"/>
    <dbReference type="OrthoDB" id="4422at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase_B" evidence="1">
        <location>
            <begin position="2"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="520" mass="56871" checksum="1349A00DB01A3934" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAD0</accession>
    <name>L0AAD0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein, probably involved in trehalose biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231970.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0292"/>
    <dbReference type="EnsemblBacteria" id="AFZ70072">
        <property type="protein sequence ID" value="AFZ70072"/>
        <property type="gene ID" value="Calag_0292"/>
    </dbReference>
    <dbReference type="GeneID" id="14211552"/>
    <dbReference type="KEGG" id="clg:Calag_0292"/>
    <dbReference type="eggNOG" id="arCOG07490">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029675_2_0_2"/>
    <dbReference type="OMA" id="DMWQYTQ"/>
    <dbReference type="OrthoDB" id="110545at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="433" mass="50967" checksum="773A3EE7AE54E6B4" modified="2013-03-06" version="1">MKCSPEILKYVNNQQWKLNCEYIDSECYDINGYVLVNERGCNETLFSVLLSRSSNIILAEENMEFLNNLLDNKINLFNFSCKNNIGKVINVKPITYGNRSAIYEIFNEYNDKFLLKINKRLEDDNIEDIILKYLTDVGYVNIPKYYCSIKYNNYYYGLITEYIEGEPAATYYVNSAIRYIKKIKNMDIIGNNIAKSLANLHNYLKECKDDFCKSEVVNEKIIEKWINRIEWREKWIRSNLDILHQDEKSFALESLDSIEELLSLIKPDLKALIGRQLMRIHGDLHLYQIIVSNNNVYFTDFEGEPYKYPANKLEKEMPERDLAALFRSIDYTAVMALQLLHGTSIGESLDLINDDILNWEYISSKEILSQYLNNISNPIKENFTQIEISLPFWLLERASYEIVYEMIARTGYHLIPMSYIIRMKEGKEKLFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAD2</accession>
    <name>L0AAD2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycine/D-amino acid oxidase, deaminating</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232765.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1146"/>
    <dbReference type="EnsemblBacteria" id="AFZ70868">
        <property type="protein sequence ID" value="AFZ70868"/>
        <property type="gene ID" value="Calag_1146"/>
    </dbReference>
    <dbReference type="GeneID" id="14212406"/>
    <dbReference type="KEGG" id="clg:Calag_1146"/>
    <dbReference type="eggNOG" id="arCOG00755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_4_1_2"/>
    <dbReference type="OMA" id="PDHNALI"/>
    <dbReference type="OrthoDB" id="45129at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="3"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="428" mass="48217" checksum="38A11F3BE0C03FFB" modified="2013-03-06" version="1">MPDYIVIGSGIVGLSTAYHISEQDKDSSILIIDKYDGPGAGDTSKSAAAFRTAFTSKLNILLSSSSIEFYSHLQKNEKFDLGMRHVGYLFSLDKNNYSVFKKGLEYAEKLGVEFSEIENDYLQNNLGIKTDIEGSEEADIIGAHNIYKSILFKNAGILDPEKIIDYYYGKLKDRNVEFSYGIGIKEFIIEPEKPLGIEGEPFAWEEIKVKGVRLNDGTIVRANKKIISALGAWSNLYLNKIGLDSYSRPKKRQIFSIKADNNELKRILYSKGFNDENTMPFVILPKGVYIRPNPSENTFWIGLSDELGRKIELEDNPVAEENFYLYSILPVLSLYFDQFKEKNPYASWAGHYDISFDGQPIIYEPYESNLIISAGTSGSGIMKGDSIGRITASLALNKEYANLFDNTEFNVSWLGLEGRLVEKELLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAF1</accession>
    <name>L0AAF1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70404">
        <property type="protein sequence ID" value="AFZ70404"/>
        <property type="gene ID" value="Calag_0653"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0653"/>
    <dbReference type="HOGENOM" id="CLU_3263596_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="41" mass="4936" checksum="764DC7F9E3B834E4" modified="2013-03-06" version="1">MKNENNNNINNKKEAFDLEEKLYMEWYMIWMETPFHGAPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAF7</accession>
    <name>L0AAF7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231923.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70025">
        <property type="protein sequence ID" value="AFZ70025"/>
        <property type="gene ID" value="Calag_0243"/>
    </dbReference>
    <dbReference type="GeneID" id="14211503"/>
    <dbReference type="KEGG" id="clg:Calag_0243"/>
    <dbReference type="HOGENOM" id="CLU_1291985_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="213" mass="24961" checksum="F833A0E93CFFB3AE" modified="2013-03-06" version="1">MTLNKIAEKLGYNYIAEISSIKIYVNSNYKSSYIVFQNDYPMMYLSKINDKYILINNFFDLENGREYEGKILSSKSFDEIGYIKFYQTKDKKLIITKIEGNIEYTWNLIDLHTPLKIDPIKPFAEILSEIKPKIIGLIDLYTDPLSLIVFNSQSFYYPPLIYGYYNHDFLNKLYKGLSLGISYNNQPLNYSFAKAEEITNVKTIIKKIIYIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAF8</accession>
    <name>L0AAF8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1139"/>
    <dbReference type="EnsemblBacteria" id="AFZ70861">
        <property type="protein sequence ID" value="AFZ70861"/>
        <property type="gene ID" value="Calag_1139"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1139"/>
    <dbReference type="eggNOG" id="arCOG01997">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079909_2_1_2"/>
    <dbReference type="OMA" id="MMAIVML"/>
    <dbReference type="OrthoDB" id="88537at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="196" mass="21743" checksum="5DCD80E475C286B2" modified="2013-03-06" version="1">MNTRELINSIIMLFVVLDPFTVVPFYIPTANLLPKEKRKKFLNTLILAAVFMLLAFTIIGDYIFKILGVTFNDFRVAAGLILLVYAISSLFDIEIGAPKNNIEDIEKEAIVPLATPLLAGPGSISTVLYIRYSYGYPIAIITIFINIVLAYLILYAGQYILKYLGEHGALLVDKFMSLILAGFAISIIRASIMSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAG6</accession>
    <name>L0AAG6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum cofactor synthesis domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1188"/>
    <dbReference type="EnsemblBacteria" id="AFZ70908">
        <property type="protein sequence ID" value="AFZ70908"/>
        <property type="gene ID" value="Calag_1188"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1188"/>
    <dbReference type="eggNOG" id="arCOG00216">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_7_2_2"/>
    <dbReference type="OMA" id="MTGAMVP"/>
    <dbReference type="OrthoDB" id="51611at2157"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="MoCF_biosynth" evidence="4">
        <location>
            <begin position="194"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="421" mass="45826" checksum="B5528910E8757BCA" modified="2013-03-06" version="1">MFKIKMKGFKELTKVDDALSLLLNNLIKPNLDYEEINIEDAYGRISYEDVRSNVNIPPYDRSAVDGYAVISSDTVGASITNPISLKIVGEIKAGDDPKIIKEINKGEAMIIYTGAPIPKNSDAVVMAEDATYKGDIVDINKPVAPYQNISKKGEDFNEGKIIIPKNTFIKPWHIGALASAGIKKIKVQRYLNIAILSTGNEIAELNENTEGKIINSTKPLLKSMLKSNQCNPIDLGTVNDNVKSIEDRIRLGLQIADMVITTGGTSVGNYDLVIDAISSIEGSKILFNGVRMRPGKPTSGAVVNGKPIIMVSGFPVAAIAAFYAFILPTINFLRNTKEEPIAKIKGKITRRIANIAGVKTYLRVKVRKEGNEIYVDPLAITASGVLSTLTEANGLLIIPENVEGYDEYDEVEVDLISPIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAH1</accession>
    <name>L0AAH1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="8">SHMT</shortName>
            <shortName evidence="8">Serine methylase</shortName>
            <ecNumber evidence="8">2.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glyA</name>
        <name evidence="12" type="ordered locus">Calag_1193</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232810.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1193"/>
    <dbReference type="EnsemblBacteria" id="AFZ70913">
        <property type="protein sequence ID" value="AFZ70913"/>
        <property type="gene ID" value="Calag_1193"/>
    </dbReference>
    <dbReference type="GeneID" id="14212453"/>
    <dbReference type="KEGG" id="clg:Calag_1193"/>
    <dbReference type="eggNOG" id="arCOG00070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_2"/>
    <dbReference type="OMA" id="SHPAGLI"/>
    <dbReference type="OrthoDB" id="22518at2157"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="11">
        <location>
            <begin position="16"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8 9">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="431" mass="48293" checksum="589C5FA046B3EF73" modified="2013-03-06" version="1">MNKEYIDKILEYTNLQNVWRVKETINLIASENVMSPLALTVYMSDFMNRYAEGKPFKRYYQGTKYSDELEVMSNELMGKLLHTDMVDIRPISGTIANASVFRILAEPGEQAVIAPVQAGAHVSHTKFGTLGALGIKQIELPYDEERMNVDIDKAIKVIEQVKPKFAVLGGSVYLFPHPVKEISNAIHSVNGKLVYDSAHVLGLIVGNAWRNPLDHGADVMTSSTHKTFPGPQGGVIAFKDKDLYKEVGKTIFPWFLSNHHLHRLPATAITALEMIEFGEAYAKQITRNAKKLAESLAERGFKVIGEHLGYTMSHQVLVDVSPQGGGAKIAKMLEDGNIILNKNLLPHDPPEAVQNPSGLRIGVQEMTRFGMKEDEMDQIAEFIEKIAIKKEDISKVREEVKEFRKNYQKVHYGYSSDLINGKYVNLLNLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAI9</accession>
    <name>L0AAI9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl19e</name>
        <name evidence="8" type="ordered locus">Calag_1175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232793.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1175"/>
    <dbReference type="EnsemblBacteria" id="AFZ70896">
        <property type="protein sequence ID" value="AFZ70896"/>
        <property type="gene ID" value="Calag_1175"/>
    </dbReference>
    <dbReference type="GeneID" id="14212435"/>
    <dbReference type="KEGG" id="clg:Calag_1175"/>
    <dbReference type="eggNOG" id="arCOG04089">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083919_1_1_2"/>
    <dbReference type="OMA" id="NRVWIDP"/>
    <dbReference type="OrthoDB" id="109335at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01418">
        <property type="entry name" value="Ribosomal_L19e_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_L19/L19e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_L19/L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_L19/L19e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_L19/L19e_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033936">
        <property type="entry name" value="Ribosomal_L19e_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="RPL19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="PTHR10722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="SSF48140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L19e" evidence="7">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="153" mass="18245" checksum="30D59B31E66E3396" modified="2013-03-06" version="1">MDYRLQKRLAAEILGVGESRIWISPDPDNEEEISQAITKDDIRGLIERGLIKKIPKKGNSHRWLIRHIKRVKGHRRGYGKREGTKKTRVDEEEVWVNKIRKMRTYLKYLRDKDMIDSQTYRRLYRLSKGNAFKSLSDLKRYIDENKLMKGVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAK0</accession>
    <name>L0AAK0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232840.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1226"/>
    <dbReference type="EnsemblBacteria" id="AFZ70943">
        <property type="protein sequence ID" value="AFZ70943"/>
        <property type="gene ID" value="Calag_1226"/>
    </dbReference>
    <dbReference type="GeneID" id="14212486"/>
    <dbReference type="KEGG" id="clg:Calag_1226"/>
    <dbReference type="eggNOG" id="arCOG01257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OMA" id="QTGSNDM"/>
    <dbReference type="OrthoDB" id="11742at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="555" mass="59692" checksum="F6D8C33BDED6AF06" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAK1</accession>
    <name>L0AAK1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0345"/>
    <dbReference type="EnsemblBacteria" id="AFZ70122">
        <property type="protein sequence ID" value="AFZ70122"/>
        <property type="gene ID" value="Calag_0345"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0345"/>
    <dbReference type="eggNOG" id="arCOG00184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="18"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="465" mass="53014" checksum="0C1776C689C90C4D" modified="2013-03-06" version="1">MSFSMESNSLSSNLAPIVKVENFHLHYYTRRGVYKALNGVNLEIRKGEVLGVAGESGCGKSTLGRAIMGLIPRNAAVVDGRILVDGKDYLKPLNEYYKKAKKFKPAKNADVLKKVNEEMSNVRGQKLSMVFQEPMTTLNPLLQVGYQIAEVLYYHNPGLLASRRLSRHRATKEDMKNIIKILKENGINEAFKDYLKNRNILGLEDQVASIWRRKDLHDLKKEQIIEKLCCEPINSFTKKYLEVIEKENKLPNFSRIPIIGRMVKRELFKEGYKKASEFLGLLGIPNADKMVYMYPHELSGGQRQRIVIATAMINNPELVILDEPTSALDVTIQAQILELIKELKESTNSSYMFISHDLSVLAEVSDRIAIMYAGQVVEVGRKEYIFDQPKHPYTQMLMEAIPTIEAHELKGIKGEVPDMRNPPKGCMFRDRCPYAMPICAEKRPDLRKVGEDHFVACFLYEVEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAP2</accession>
    <name>L0AAP2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L31e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl31e</name>
        <name evidence="6" type="ordered locus">Calag_0408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ribosomal protein L31e family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232075.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0408"/>
    <dbReference type="EnsemblBacteria" id="AFZ70177">
        <property type="protein sequence ID" value="AFZ70177"/>
        <property type="gene ID" value="Calag_0408"/>
    </dbReference>
    <dbReference type="GeneID" id="14211668"/>
    <dbReference type="KEGG" id="clg:Calag_0408"/>
    <dbReference type="eggNOG" id="arCOG04473">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2177760_0_0_2"/>
    <dbReference type="OMA" id="YWGRRTR"/>
    <dbReference type="OrthoDB" id="115384at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00410">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_L31e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_L31e_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="SSF54575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="109" mass="12874" checksum="1484D90662158C12" modified="2013-03-06" version="1">MEIGEAFVYVVPLKRIYFGRKSNRAKRAIDYIRKFVSRHAKVNLEDVVIMDDVNSYIWSNSIEKPPRRVKILVEMKEFKPEEGEAYKKVLVRLAGEKVRVGKYEIKNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAS1</accession>
    <name>L0AAS1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232115.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0450"/>
    <dbReference type="EnsemblBacteria" id="AFZ70217">
        <property type="protein sequence ID" value="AFZ70217"/>
        <property type="gene ID" value="Calag_0450"/>
    </dbReference>
    <dbReference type="GeneID" id="14211710"/>
    <dbReference type="KEGG" id="clg:Calag_0450"/>
    <dbReference type="HOGENOM" id="CLU_640301_0_0_2"/>
    <dbReference type="OMA" id="KENGFEM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="424" mass="47333" checksum="8C951173EE4295BF" modified="2013-03-06" version="1">MLKIKLDKGKDIDKLKLQISAALNKVLQESKDNNILRIIVYPSLENIIGGLMLFNVALNLNIKASISTRLNAPSKITDPTILIGYSNLNYKVSDIESVLVSLSHEINEIPIGNSTFVEINGSIGSGIYFALKGSDIINVKPEYAILSLASTYASKYVSKSGEFSSFDKDVIETLITSDDSLNMEIVTGLKIFRPTSLNFCESLSITLNPLYLTLTNEDSCQRFLKENGFEMLINSNIGKIDNETNKNITVSIYKYLKDNIIKNKIDIQEYVGGVGVSKARIVMQDPREVIYSIMLLIETMGFHSAVGLIADYENEYPQIPHYLRSSVKIAEDVILNNKFNRASQINFAKVYVTNEDNLPITAIQKQLKIMGYIDNDAILGYLDKNKLKIPILSLEDSLGYGSAARFIQTFKGEFDGESVWIKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAS6</accession>
    <name>L0AAS6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">GTP cyclohydrolase III</fullName>
            <ecNumber evidence="4 5">3.5.4.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gch3</name>
        <name evidence="6" type="ordered locus">Calag_0338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:22468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57258"/>
            <dbReference type="EC" id="3.5.4.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the archaeal-type GTP cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.29" evidence="4 5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232013.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0338"/>
    <dbReference type="EnsemblBacteria" id="AFZ70115">
        <property type="protein sequence ID" value="AFZ70115"/>
        <property type="gene ID" value="Calag_0338"/>
    </dbReference>
    <dbReference type="GeneID" id="14211598"/>
    <dbReference type="KEGG" id="clg:Calag_0338"/>
    <dbReference type="eggNOG" id="arCOG04202">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080076_0_0_2"/>
    <dbReference type="OMA" id="VQIAHID"/>
    <dbReference type="OrthoDB" id="56576at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043740">
        <property type="term" value="F:GTP cyclohydrolase IIa activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00608">
        <property type="entry name" value="GTP_cyclohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007839">
        <property type="entry name" value="GTP_CycHdrlase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42202">
        <property type="entry name" value="PTHR42202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05165">
        <property type="entry name" value="GCH_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009265">
        <property type="entry name" value="GTP_cyclohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="235" mass="26193" checksum="4BEB47BAD08B2782" modified="2013-03-06" version="1">MIRISIIEQIGYREWTETIGTDREWKIQETQAKIYQEAQRIATKFGGFVLPLRYDYMTIISSNLTEDEEKEILEVVSSLSPVAVRLSSDLGTTPLESENNAWSHISSIEPGKLGHFGNGKEFVIVSHIDLNGLTPITQKIGTFRTYGKILQILEKINSIAQGNGGVAQYLGGDNILVLLPDSNYEDLVTKMISTDDLKAGIAIANKARDAMKLAAEALHEIRVTRNKRIVKKSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAT0</accession>
    <name>L0AAT0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="9">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA wyosine derivatives biosynthesis protein Taw1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">taw1</name>
        <name evidence="12" type="ordered locus">Calag_1311</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232920.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1311"/>
    <dbReference type="EnsemblBacteria" id="AFZ71023">
        <property type="protein sequence ID" value="AFZ71023"/>
        <property type="gene ID" value="Calag_1311"/>
    </dbReference>
    <dbReference type="GeneID" id="14212571"/>
    <dbReference type="KEGG" id="clg:Calag_1311"/>
    <dbReference type="eggNOG" id="arCOG04174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007952_3_0_2"/>
    <dbReference type="OMA" id="HRCLQMT"/>
    <dbReference type="OrthoDB" id="36053at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01921">
        <property type="entry name" value="TYW1_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023993">
        <property type="entry name" value="TYW1_archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="PTHR13930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03972">
        <property type="entry name" value="rSAM_TYW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="53"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ71023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="347" mass="40079" checksum="095B9F35538B2477" modified="2013-03-06" version="1">MEKVKMQDTYEALNEILKKQGYHLIGNHSSVKKCYWNHKAITENRFCYKSKFYGIESHRCIQLSVSNHWCWNACTHCWRLRPQDVGLEWNETNMPYNDDPKFIVDNAIKEYRRIMSGYKGRPGTDIKMYEEAMNPKHVAISLTGEATLYPRLGELIKEFHSRGISTFLVTRGIRPDILANLEEEPSQIYISLEAWDKDSYNLFNKPLVPRGWELTMETLEMLPSFSSTTVYRITVVKGFNDSEEAINGFAKLIKLGMPNYVEVKAYMFVGASKGRLTRDNMPNYEEVKEVAQKLSKACGYPIVSESKPSRVVLLSNMDKPIRYGNGMPMGWNSIEEESPGEYEEDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAT4</accession>
    <name>L0AAT4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Uridine phosphorylase</fullName>
            <ecNumber evidence="5 9">2.4.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_1317</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>phosphate + uridine = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.3" evidence="5 9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232925.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1317"/>
    <dbReference type="EnsemblBacteria" id="AFZ71028">
        <property type="protein sequence ID" value="AFZ71028"/>
        <property type="gene ID" value="Calag_1317"/>
    </dbReference>
    <dbReference type="GeneID" id="14212577"/>
    <dbReference type="KEGG" id="clg:Calag_1317"/>
    <dbReference type="eggNOG" id="arCOG01324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_0_0_2"/>
    <dbReference type="OMA" id="MSDVFHL"/>
    <dbReference type="OrthoDB" id="92495at2157"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010058">
        <property type="entry name" value="Uridine_phosphorylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01718">
        <property type="entry name" value="Uridine-psphlse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="10">
        <location>
            <begin position="30"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ71028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="279" mass="30839" checksum="003DFE45E931598F" modified="2013-03-06" version="1">MNEKLLSANRPESKDGRQYHINLSYGEVSKYVLLPGDPDRVEIIASFMDSYKIISSRREYKTANGKYKGIDISITSTGIGGPSISIALEELLRAGANTFIRIGTSGALQPFINVGDLIIGTSSFRLDGASNDYVERGYPATANYEIVNALIQAAESLNVRYHVGIIASTDTFYVGQGRPGFNNYLPKNKENIVEDLMKLNVLAFEMESSTLFTLSQIFKARAGCVCSAVANRIKDEFVVNAGIDDASKVALEATKILYEWDGIKEKYNKKWFYPGLIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAT8</accession>
    <name>L0AAT8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription initiation factor TFIIIB, Brf1 subunit/transcription initiation factor TFIIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0354"/>
    <dbReference type="EnsemblBacteria" id="AFZ70130">
        <property type="protein sequence ID" value="AFZ70130"/>
        <property type="gene ID" value="Calag_0354"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0354"/>
    <dbReference type="eggNOG" id="arCOG05931">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1472000_0_0_2"/>
    <dbReference type="OMA" id="MKKMINI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="190" mass="22151" checksum="702B4E4ADB0ECAB7" modified="2013-03-06" version="1">MKKMINIKCPYCGSHRLAWSNETGYLVCQNCGAVLQSLIDDNAYHIDKSAKDNKTNYFRIYHSSENSIDKKLEKSIKKGKFFEVDLTGKVHISSIIDKKLEKLKNSDKFKLSYEILKNYPILKSRTKRNQYAIALYALYRSYGYSIEKSIMLVSKELGVSKLSLKSIIRKNKNIINKYEIEVRRSFLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAU0</accession>
    <name>L0AAU0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232898.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1287"/>
    <dbReference type="EnsemblBacteria" id="AFZ71001">
        <property type="protein sequence ID" value="AFZ71001"/>
        <property type="gene ID" value="Calag_1287"/>
    </dbReference>
    <dbReference type="GeneID" id="14212547"/>
    <dbReference type="KEGG" id="clg:Calag_1287"/>
    <dbReference type="eggNOG" id="arCOG00040">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1096674_0_0_2"/>
    <dbReference type="OMA" id="DANSWKD"/>
    <dbReference type="OrthoDB" id="110748at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="96"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="253" mass="28724" checksum="08863FE5F727CB23" modified="2013-03-06" version="1">MNIKIKLLAALKYRANGNEVIDIDANSWKDALKKLVNIYPELSIAIESDGTPKAGFMVFVDGVDYRIKDENEEAKEIYLLPVNHGGIEALLLLWEDIEKEVDTIADKIIKSDYKPDVIISILRGGVIPGRLLADRLDISDIGSMEIKLYIAAGQKGERPYMRQPVTLPIKDKRVLLVDDVSDSGLTLNFAIQAISLYMPLEIKTATLYVKPWTRLVPDFYSKEVDKWVVFPWEKKEFEKEAKSMHDLIIKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAU5</accession>
    <name>L0AAU5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232903.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1292"/>
    <dbReference type="EnsemblBacteria" id="AFZ71006">
        <property type="protein sequence ID" value="AFZ71006"/>
        <property type="gene ID" value="Calag_1292"/>
    </dbReference>
    <dbReference type="GeneID" id="14212552"/>
    <dbReference type="KEGG" id="clg:Calag_1292"/>
    <dbReference type="eggNOG" id="arCOG08851">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2127707_0_0_2"/>
    <dbReference type="OMA" id="ACAKECF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="113" mass="13186" checksum="C99EA06A24688237" modified="2013-03-06" version="1">MFKEIAEDIINSINSDLNGYIIDKREINVMDLNKLINMSGIEKLVKRVDMDKIIVLYINEDLILNKCLYDGCSKIQDTIQKKACAKECFKEQLKIFKEEIIKNLRETAKNLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAU6</accession>
    <name>L0AAU6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal-protein-alanine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1329"/>
    <dbReference type="EnsemblBacteria" id="AFZ71038">
        <property type="protein sequence ID" value="AFZ71038"/>
        <property type="gene ID" value="Calag_1329"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1329"/>
    <dbReference type="eggNOG" id="arCOG00833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_7_2_2"/>
    <dbReference type="OMA" id="MSMQNAN"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:peptide alpha-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="PTHR23091"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ71038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="189" mass="22091" checksum="057E7235B67D7369" modified="2013-03-06" version="1">MKYNSNDFIIRVANEDDIPEVMEVNLRTLPENYWYGFYKFVLDRWGDIFLIAELNGKIIGYIMNRIEDTRDPVLLGKENELSHNKEKKKSFDNIMSSLKNVFSESHKVGHVISIAVLPEYRKKGIGTALLKEAISRMKDNYNAESVYLEVRVSNNDAISLYKKMGFEEVRIIKEYYRDGEDAYVMVKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAV1</accession>
    <name>L0AAV1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type Na+ efflux pump, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_1334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232940.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1334"/>
    <dbReference type="EnsemblBacteria" id="AFZ71043">
        <property type="protein sequence ID" value="AFZ71043"/>
        <property type="gene ID" value="Calag_1334"/>
    </dbReference>
    <dbReference type="GeneID" id="14212594"/>
    <dbReference type="KEGG" id="clg:Calag_1334"/>
    <dbReference type="eggNOG" id="arCOG01462">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055390_0_0_2"/>
    <dbReference type="OMA" id="IMMLIIM"/>
    <dbReference type="OrthoDB" id="31143at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ71043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="404" mass="44165" checksum="0E7A4560DB1A676A" modified="2013-03-06" version="1" precursor="true">MKNMKSKAIIWKELLDLSRDRKTLAAMILIPFIGLPAIALLASGLTQTQTTTVYIEVLDNNSNNIAKYISYQLIQYSKINGLRVNVTISNETPSSVYNLLLIIPKGFYENISSIDGVGTVYLKSLVGSLQSSEVESIIESIITQLENNIVTNRVQKLSNISGIKINTNNFLNPINIFTGYYLPSGKPASAAQVELSLSARLLEFSLFFVANPAIVFMGDSILGEKERKTLETLISTPSSKTSLIIGKMIASVIIGLITAIADSLGVIIYLSMIAQGELKLTAGLILVTFSVSALLVVMTAAIITPIVLRSSSVRSAQAMSYLIMMVALGIYFSTLFVDIQRLPYYIEDILLVIPFTHAALAVSNFVLGQYLNMGINFLVMIGFTLLGIYISIKTFDSERLILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAX2</accession>
    <name>L0AAX2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease V</fullName>
            <ecNumber evidence="2">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Deoxyribonuclease V</fullName>
            <shortName evidence="2">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nfi</name>
        <name evidence="3" type="ordered locus">Calag_0513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endonuclease V family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232175.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0513"/>
    <dbReference type="EnsemblBacteria" id="AFZ70277">
        <property type="protein sequence ID" value="AFZ70277"/>
        <property type="gene ID" value="Calag_0513"/>
    </dbReference>
    <dbReference type="GeneID" id="14211773"/>
    <dbReference type="KEGG" id="clg:Calag_0513"/>
    <dbReference type="eggNOG" id="arCOG00929">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047631_1_1_2"/>
    <dbReference type="OMA" id="RIHFRQA"/>
    <dbReference type="OrthoDB" id="80668at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with target DNA" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="256" mass="28887" checksum="4BBAFA073DCE6EF2" modified="2013-03-06" version="1">MIKDDNNCVGIRENFNVSIAINDQILFSKKINLNDFINIRDIENKVIAAVDASYTKNDLGIGVAIAFEYPSYNIIDCELIARKVCIPYIPGLLAFREMYLISTPLLKLLKKVKPQVLFVDGHGYAHPRFAGIATHIGIVFDIPTIGIAKKKLVGEEVVENNELYLRFKDRLVSKILLINNKKIYVSPGNKISLENSFNITKLMIGKFNLPIPIYLADKLSKIAKRNLEVSYLDSSNIFSINNNLSNLCKKLINKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAY2</accession>
    <name>L0AAY2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232185.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0525"/>
    <dbReference type="EnsemblBacteria" id="AFZ70287">
        <property type="protein sequence ID" value="AFZ70287"/>
        <property type="gene ID" value="Calag_0525"/>
    </dbReference>
    <dbReference type="GeneID" id="14211785"/>
    <dbReference type="KEGG" id="clg:Calag_0525"/>
    <dbReference type="eggNOG" id="arCOG04394">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127515_4_2_2"/>
    <dbReference type="OMA" id="GWAYIRP"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="121" mass="14036" checksum="3352289CE4A03912" modified="2013-03-06" version="1">MIEKIKVLFHIDRNDEETLILSLNNIRNFIEEANAENYTYEIILLANYKAPLLFLKNNINKNTLEFIKNLKEKGVKVLICEKSMKSLKITKEELIDECEITPSGVFTIAKLEKLGFAYIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB63</accession>
    <name>L0AB63_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232551.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0923"/>
    <dbReference type="EnsemblBacteria" id="AFZ70654">
        <property type="protein sequence ID" value="AFZ70654"/>
        <property type="gene ID" value="Calag_0923"/>
    </dbReference>
    <dbReference type="GeneID" id="14212183"/>
    <dbReference type="KEGG" id="clg:Calag_0923"/>
    <dbReference type="eggNOG" id="arCOG01389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_932553_0_0_2"/>
    <dbReference type="OMA" id="VEANRYK"/>
    <dbReference type="OrthoDB" id="105370at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="298" mass="34602" checksum="2E19F90B636F65A1" modified="2013-03-06" version="1">MICVGIPTYNRSEIFNRSLLSFYNNNYIDLILVVADADKKVEANRYKQILDQFNKKIYYQVNIGRSGSVNSRNKILILGYELGCDELIMADDDYILIDNKTPLILSLHIKNGAGMCGGKVINLARRSIDPDFFLNTIIADNLSDITGYVFLDIKHGPRYAKYVPHFFSIDGDILNKVRYDKLYDTPTAFREESDLQRQIRSLGFNIVFDPRAWIIHLDIEEGGDRNNMDENKRLYWKSFGSTSFILKWEKNIKLLSKLVMASMIIISYRPMRFISIFKGIRDSLYNFKNKNNEVLPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB67</accession>
    <name>L0AB67_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232556.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0928"/>
    <dbReference type="EnsemblBacteria" id="AFZ70659">
        <property type="protein sequence ID" value="AFZ70659"/>
        <property type="gene ID" value="Calag_0928"/>
    </dbReference>
    <dbReference type="GeneID" id="14212188"/>
    <dbReference type="KEGG" id="clg:Calag_0928"/>
    <dbReference type="eggNOG" id="arCOG00434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_1_2"/>
    <dbReference type="OMA" id="RDRFMFS"/>
    <dbReference type="OrthoDB" id="49734at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="37"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="303" mass="34208" checksum="BD7E584C70BB704F" modified="2013-03-06" version="1">MKPEGAAKIKNEIINTIGKYYVGGKEVIEIMLENLISGGHILLEGYQGLGKTTIAKLFSQAIGVEFKRIQMVSDLLPSDIIGTSIWDPEKKEFKIREGPIFSNIVLIDEFNRAPPRTQSALLEAMQEKQVTIDLNTIKLPDPFLVIATQVPYDTGGIFPLTITQIDRFSSKIVISLPSRDEEIEILRRVDILDTPSIKPIINKDLIFDMRESIKNVKISDEILGYILDIINEVRKFGNLSVRSSLWVLKLSRVNAFLDGRDYVIPDDVKKVSYHVLRHRISSESANPDNIIENALRNVKVPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABB5</accession>
    <name>L0ABB5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70709">
        <property type="protein sequence ID" value="AFZ70709"/>
        <property type="gene ID" value="Calag_0986"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0986"/>
    <dbReference type="eggNOG" id="arCOG04165">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151699_0_0_2"/>
    <dbReference type="OMA" id="YASEMGI"/>
    <dbReference type="OrthoDB" id="121654at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="117" mass="13592" checksum="91BD9EF1945A1FE3" modified="2013-03-06" version="1">MPTVHLSISDQMYSELKNKSDEIGIQITDLIKLYIKTGLQGGFSNKNEDNLIIANLSNRLDKVEKDVRVKMTLLEGKYRQIEETLDYLIQRIDSLEDLLTEYKTKKRVVQQSEEQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABE3</accession>
    <name>L0ABE3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L40e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl40e</name>
        <name evidence="5" type="ordered locus">Calag_1474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233073.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1474"/>
    <dbReference type="EnsemblBacteria" id="AFZ71176">
        <property type="protein sequence ID" value="AFZ71176"/>
        <property type="gene ID" value="Calag_1474"/>
    </dbReference>
    <dbReference type="GeneID" id="14212734"/>
    <dbReference type="KEGG" id="clg:Calag_1474"/>
    <dbReference type="eggNOG" id="arCOG04049">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175093_1_0_2"/>
    <dbReference type="OMA" id="FQYKICR"/>
    <dbReference type="OrthoDB" id="127293at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00788">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="L40e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_L40e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023657">
        <property type="entry name" value="Ribosomal_L40e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39649">
        <property type="entry name" value="PTHR39649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L40e" evidence="4">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="57" mass="6613" checksum="FB58C70D465F9A31" modified="2013-03-06" version="1">MPITDPELIKIVEKRVFEVSICRRCGAKNPLNAKKCRRCRGTDLRPKKKELAKFKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABJ2</accession>
    <name>L0ABJ2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylisocitrate lyase</fullName>
            <ecNumber evidence="3">4.1.3.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1532"/>
    <dbReference type="EnsemblBacteria" id="AFZ71231">
        <property type="protein sequence ID" value="AFZ71231"/>
        <property type="gene ID" value="Calag_1532"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1532"/>
    <dbReference type="eggNOG" id="arCOG00581">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027389_3_2_2"/>
    <dbReference type="OMA" id="QTELWNK"/>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012695">
        <property type="entry name" value="PrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02317">
        <property type="entry name" value="prpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ71231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="305" mass="34193" checksum="C95F8819AC2D010E" modified="2013-03-06" version="1">MAFLYKRRLENPGEMLRELLKKEDIIITPGVFDPASALLVESLGFKSAYLSGAALTGSLAMPDLGLITFSELFDTTRRITNVINIPLIVDSDTGFGESLNVYRTVKELEEAGAAAIQIEDQDMPKKCGHLSGKKTISAEDMVKKIVAANNARRDMLIVARTDSRATEGIEAAIERAKLYLEAGADIIFPEALTSIDEFKLFAREVRAPLLANMTEFGKTPYITAQEFKEAGFKIVIFPVTTFRAAMKAMKDTLIEIRDKGTQKFILDKIMSREEFYNLIGYYEYEKRDNEFAKKGDEIIIKKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABJ6</accession>
    <name>L0ABJ6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl4</name>
        <name evidence="5" type="ordered locus">Calag_0671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232318.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0671"/>
    <dbReference type="EnsemblBacteria" id="AFZ70420">
        <property type="protein sequence ID" value="AFZ70420"/>
        <property type="gene ID" value="Calag_0671"/>
    </dbReference>
    <dbReference type="GeneID" id="14211931"/>
    <dbReference type="KEGG" id="clg:Calag_0671"/>
    <dbReference type="eggNOG" id="arCOG04071">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026535_0_0_2"/>
    <dbReference type="OMA" id="WHQKVNV"/>
    <dbReference type="OrthoDB" id="65833at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_A">
        <property type="entry name" value="Ribosomal_L4_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_L4_euk/arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019970">
        <property type="entry name" value="Ribosomall_L4-archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="PTHR19431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03672">
        <property type="entry name" value="rpl4p_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="273" mass="30194" checksum="7EC5155CF8309C9A" modified="2013-03-06" version="1">MVSISSSMLFYLSPKVSVIKYNSKGEEEGEIELPDVFRIPIRRDLILRAFLSEFTASIQPKARDPMAGKRTTAKSLGIGHGVARVPRIKGGMRAAFVPMVRKGRAAFPPRLDEKIHEEINKKERTLAIMSSLAATAIPDLVKERGHEFDSKTVPIIINSDILNEIKKAKEAREILGKIGIYKDIERAAERIRVRSGKGKMRGRTYKNVNSILFIVENHNSPFARSVTNMPGVDVIEPNLVSVTHLSPGGVPGRLTVITTEALNALSKRFSLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABK2</accession>
    <name>L0ABK2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1543"/>
    <dbReference type="EnsemblBacteria" id="AFZ71241">
        <property type="protein sequence ID" value="AFZ71241"/>
        <property type="gene ID" value="Calag_1543"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1543"/>
    <dbReference type="eggNOG" id="arCOG01631">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068443_2_1_2"/>
    <dbReference type="OMA" id="RVVSFCW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026170">
        <property type="entry name" value="FAM173A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610">
        <property type="entry name" value="PTHR13610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="4">
        <location>
            <begin position="44"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="178" mass="20093" checksum="E7950C622345BE67" modified="2013-03-06" version="1">MNKELEEAEKELGWIAMAFGGPSVPFVPTRKEVFDLVFEALDLKENDVLYDLGCGDGRIIIEAAKKYPIKKAVGVEMREELVKDIANKIREEKLDGRVEIIQGDFFKTPISDATVVYMYLLTSVNEALKPKLKQELKPGTKVVTLDFQIPGWKPVKIIGDKLGWQKTLYVYIIGQSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABK5</accession>
    <name>L0ABK5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with HTH domain and aminotransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232328.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0684"/>
    <dbReference type="EnsemblBacteria" id="AFZ70430">
        <property type="protein sequence ID" value="AFZ70430"/>
        <property type="gene ID" value="Calag_0684"/>
    </dbReference>
    <dbReference type="GeneID" id="14211944"/>
    <dbReference type="KEGG" id="clg:Calag_0684"/>
    <dbReference type="eggNOG" id="arCOG00492">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_2"/>
    <dbReference type="OMA" id="MRLNFTY"/>
    <dbReference type="OrthoDB" id="51060at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="49"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="403" mass="44936" checksum="0F6C1AD9486A3298" modified="2013-03-06" version="1">MIDYSSRISYRSQSLRPSEIREILSLTEGKNIISLAGGLPGPEVFPKQQLADIAKRVLEDLGEEALQYSPTLGVTPFRNAIMSFASSKGIKVNEDDRVAVTTGSQEAIYLIGLSLIDPGDNIIVEAPTYLAALNAFRFFGANFISIPLDEDGMKVEMIENEIKKGIESGKKIKAIYTVATSHNPTGVIMNDERRKHLIEIANKYDLLIIEDDPYGFFVFDTDKRFTSLKTLDTEGRVIYMGTFSKILAPGLRLGYMIAPRQFTRTVELGKQIVDLHSSTLSQFIAMYAIKEGVVDETIENARKVYRKKRDVLIEALEEYMPKGSEWYKPKGGLFAFVYLPKGVDTTEMLPTAINKGVAYVPGRNFFADGSGGNAMRINFSYPSIDKLREGIKIIGETAKEMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABN2</accession>
    <name>L0ABN2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0710"/>
    <dbReference type="EnsemblBacteria" id="AFZ70455">
        <property type="protein sequence ID" value="AFZ70455"/>
        <property type="gene ID" value="Calag_0710"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0710"/>
    <dbReference type="eggNOG" id="arCOG06008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_942587_0_0_2"/>
    <dbReference type="OMA" id="LDGPVYF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="302" mass="32741" checksum="EDD66775D479A601" modified="2013-03-06" version="1">MHGDKMNFIEFILNPSGELTLVSIIAISFILGILHGITPDEHTWPITFSYAIGKYSTKGGLLAGLLFSLGFTIQRALLTTIGYLGLARIYQVYNLDGPVYIAVGIVMAIAGSYVLHGKYVHIHLIPSHRHTEKAERVEMPKDVPLKMTIIHGLIAGFGFGAYASIITFVLAPKVPSLIYSPLPGLFFGLGTMTMQIILGAFFGGIMRKMGYNENDIKFVGTKTAGNTLYYGGIAFALIGLLVVMMPSIDNFAISTGIQIPNLNAIDIGFILVIFVVGAIGIGSLVKTVYELRKGKLNVINRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABQ0</accession>
    <name>L0ABQ0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232751.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1132"/>
    <dbReference type="EnsemblBacteria" id="AFZ70854">
        <property type="protein sequence ID" value="AFZ70854"/>
        <property type="gene ID" value="Calag_1132"/>
    </dbReference>
    <dbReference type="GeneID" id="14212392"/>
    <dbReference type="KEGG" id="clg:Calag_1132"/>
    <dbReference type="HOGENOM" id="CLU_2802006_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="67" mass="7946" checksum="7930E026B6CD28F0" modified="2013-03-06" version="1">MIKSQKIKFIELKENYKLLNCKNEECLEYCKENKEIIIIMPASKMWIIGDRLPKDCIIIGEGDKIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABQ3</accession>
    <name>L0ABQ3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase</fullName>
            <ecNumber evidence="2">2.7.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15669"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13184"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136416"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.78"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end dephospho-ribonucleoside-RNA + ATP = a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54580"/>
            <dbReference type="Rhea" id="RHEA-COMP:13935"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.78"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.1.78" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232372.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0730"/>
    <dbReference type="EnsemblBacteria" id="AFZ70475">
        <property type="protein sequence ID" value="AFZ70475"/>
        <property type="gene ID" value="Calag_0730"/>
    </dbReference>
    <dbReference type="GeneID" id="14211990"/>
    <dbReference type="KEGG" id="clg:Calag_0730"/>
    <dbReference type="eggNOG" id="arCOG04127">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_830540_0_0_2"/>
    <dbReference type="OMA" id="IASCIMR"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="PTHR12755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLP1_P" evidence="6">
        <location>
            <begin position="94"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="340" mass="38342" checksum="8FC3361672B1617C" modified="2013-03-06" version="1">MNCEKFDGSYILLGPSSVVIINGEVEILGFDINKKINKKIIVPIGRSIPIKANNACLNINPSSKNIVKVESKTNEIFEKIYNEIFEKRKILIIGPTDSGKSTLAAFLINRFYSKGIRAKIMSADLGQNEVYCPTFVSTAEIDPPYIPGWKGSIANVKSCFVGDISSFHNKQKYIECIEKLGKDDNLIIDTDGLVNEEAIKLKLSLIQNIDIDAVISIDLNYEITNLNNIKIIQVNKLFNKEKSRYERKENRDRLISQCILSSRKRIINLNEINITNKENLFPGSIAGIESPDGNQYFGLIYKIINDNAVLITEYDSKINRIEVGKLTLNINNYKNLIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABR0</accession>
    <name>L0ABR0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription initiation factor IIB</fullName>
            <shortName evidence="5">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tfb</name>
        <name evidence="8" type="ordered locus">Calag_1142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1142"/>
    <dbReference type="EnsemblBacteria" id="AFZ70864">
        <property type="protein sequence ID" value="AFZ70864"/>
        <property type="gene ID" value="Calag_1142"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1142"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="RTQKDFA"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CYCLIN" evidence="7">
        <location>
            <begin position="131"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="5">
        <location>
            <begin position="229"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="7">
        <location>
            <begin position="229"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="317" mass="35111" checksum="B92594FDEBB4C2B3" modified="2013-03-06" version="1">MKCMSQSQDSGKDQSKSSVKCPPDKIIYDANMGARICLETGEVIEEQVIGDEAEWRAYTPDEKARRTRVGGPLSLSKPNMGVDVYIGSFHEGSGKKIRGLSRRIDMLRLQRSFRMGRTLSSLEKNINQALKILDELATHMELSNKVREEASKMYRDATQKGLTRGRSIESVVAATLYAACRKLRIPCTIDEIAKHLSIKDNDVKREIARCYRLLVRDLEVDIPVIEPELFVNRIVSALGLPDYVAVEAIKILREARGKGTTAGKDPSGLAAAAVYLAALKHGLRRTQKEVAHVAGVTEVTVRNRYKEIAGEAASKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABV0</accession>
    <name>L0ABV0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N2,N2-dimethylguanosine tRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232806.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1189"/>
    <dbReference type="EnsemblBacteria" id="AFZ70909">
        <property type="protein sequence ID" value="AFZ70909"/>
        <property type="gene ID" value="Calag_1189"/>
    </dbReference>
    <dbReference type="GeneID" id="14212449"/>
    <dbReference type="KEGG" id="clg:Calag_1189"/>
    <dbReference type="eggNOG" id="arCOG01219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010862_5_1_2"/>
    <dbReference type="OMA" id="VFYNPVM"/>
    <dbReference type="OrthoDB" id="70865at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004809">
        <property type="term" value="F:tRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="PTHR10631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 7" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="383" mass="43820" checksum="4EEF02BABF3C8633" modified="2013-03-06" version="1">MRLSVIKEGKALIYIPDTRDAQISKGIIEPSHLDVFYNPVMEFNRDLSVLAVSTFIESYWPGKEVIGIDPLSATGIRGIRYSLEINSMSKVIINDIDKDAYDIMVKNVELNGVKNVDVYNKDANSLMRSIRFEQNQIINIIDLDPFGSILPFIDTAISVSSKGTLLALTATDLAVLGGSKYIAAKRKYRVNLISIKHYREIALRVLLAFIAYVAASYDKVIKPLIAYSVDHYARVYLLIDRGTKKSEEMLNKNIGYYKYENGILMKCDNNCYGPIWNGNISDIEFLKSINDKLKDFSYVETYQRMDKFVKMYLNEMEFSNYYHQRLDTICQSQKINMPSIIKFISALENKGYKAFRSTFSNVGFRSNAPYDVLIETCREFKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABX6</accession>
    <name>L0ABX6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FeS assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0877</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232514.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0877"/>
    <dbReference type="EnsemblBacteria" id="AFZ70617">
        <property type="protein sequence ID" value="AFZ70617"/>
        <property type="gene ID" value="Calag_0877"/>
    </dbReference>
    <dbReference type="GeneID" id="14212137"/>
    <dbReference type="KEGG" id="clg:Calag_0877"/>
    <dbReference type="eggNOG" id="arCOG04236">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_2"/>
    <dbReference type="OMA" id="MAMLEPK"/>
    <dbReference type="OrthoDB" id="44302at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="249" mass="27671" checksum="B70B3F94578D4521" modified="2013-03-06" version="1">MALETIDLTVNVGEKQILNNMNLKVEKGEALILMGPNGSGKTTLAFSLLGHPKYQINKGKILLDNNDITDLPTYQRALMGLGLAFQNPVEVPGLMLSMLINAISMKRNKSDFDISSIDPKLIIWARNKAKELGLVPSILEREVNVGFSGGEKKRSEMLQMLVMDPKYIIFDEPDSGLDVDGIRIIGELINSLRNSGKGILIITHHAEITKFVYPDKVIVISKGKIVDEGGEELIKKIEEYGYKDYEEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACC2</accession>
    <name>L0ACC2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232971.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1365"/>
    <dbReference type="EnsemblBacteria" id="AFZ71074">
        <property type="protein sequence ID" value="AFZ71074"/>
        <property type="gene ID" value="Calag_1365"/>
    </dbReference>
    <dbReference type="GeneID" id="14212625"/>
    <dbReference type="KEGG" id="clg:Calag_1365"/>
    <dbReference type="eggNOG" id="arCOG03770">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2379218_0_0_2"/>
    <dbReference type="OMA" id="NGMITTR"/>
    <dbReference type="OrthoDB" id="121216at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="99" mass="11370" checksum="136D5EC195C551B9" modified="2013-03-06" version="1">MSSLFGINFYYQAILLLVVLVIVILLTIRQANELRKIAETQKRPKFITLEDCNGMITTRDFRQGDFVGLMEGPCDNNGNIRKIVGIYAIKEEKTKNKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACD6</accession>
    <name>L0ACD6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232694.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1075"/>
    <dbReference type="EnsemblBacteria" id="AFZ70797">
        <property type="protein sequence ID" value="AFZ70797"/>
        <property type="gene ID" value="Calag_1075"/>
    </dbReference>
    <dbReference type="GeneID" id="14212335"/>
    <dbReference type="KEGG" id="clg:Calag_1075"/>
    <dbReference type="eggNOG" id="arCOG01369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="OMA" id="VRWMERI"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="3"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="303" mass="34645" checksum="D1821E32C2B98D4C" modified="2013-03-06" version="1">MYIITGGAGFIGSNISDELDKNKEEFLIIDNLYSSNSYERNKKIVIADVSNYDQIKFIENIKEEINIIHLASIVNVEESRINPLNTFKSNVMGTVNIMELARKTDAYVTIASSAAVYGEKNHMPIKEDDEKNPINLYGYTKLMEEEILFSYMKEYSLKGSALRLFNVYGPKMKKGPYSGVIQIFISKILNNERPIIYGDGRNTRDFIYVKDVVNAFLNAIKYKANGIYNIGTGKETSIKQLLNIIENILNVYIEPIYDEPRKNDIRFSVADIEKAKNDLNWEPKIDLNEGLKKTIDFIKSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACG2</accession>
    <name>L0ACG2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232991.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1385"/>
    <dbReference type="EnsemblBacteria" id="AFZ71094">
        <property type="protein sequence ID" value="AFZ71094"/>
        <property type="gene ID" value="Calag_1385"/>
    </dbReference>
    <dbReference type="GeneID" id="14212645"/>
    <dbReference type="KEGG" id="clg:Calag_1385"/>
    <dbReference type="eggNOG" id="arCOG04151">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048986_0_0_2"/>
    <dbReference type="OMA" id="FPIITSK"/>
    <dbReference type="OrthoDB" id="116265at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007254">
        <property type="entry name" value="DUF373"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38815">
        <property type="entry name" value="PTHR38815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04123">
        <property type="entry name" value="DUF373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="378" mass="41499" checksum="0F3D29129712DCA4" modified="2013-03-06" version="1">MSENTKKPLILIIDIDDDIGSVTGKSLVYGKEDVMKAALEFAEKRPEDADTNAIFAGLNLYESMKNSSKEPDIAIVGGHPTNTLLAQMFVKDRVKQLIDKIGNNVELYLVSDGTDELLIAEVLRELAPIAGLKRVIVEQHLGVEGSYFLLARYIRKAINDPRYSKYFLGIPGVLIALFGILSIFGYIILALKVILAIAGIFLILKGFNIENKSYNAMRSLANYLRETSHFQIAGLGILAVTILASIVAGYYSFVTRPKNLIILIGSVSANSLPILLAGFTLYIVVARIFYKVTKSNLYIFKEIASIAVIVSLAFAFSQLGLSLETYGLSLNLITASDIINIFIGSGFLLYSVAGAGVAALIELVDYLYFRHYKRAEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACG9</accession>
    <name>L0ACG9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233001.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1396"/>
    <dbReference type="EnsemblBacteria" id="AFZ71104">
        <property type="protein sequence ID" value="AFZ71104"/>
        <property type="gene ID" value="Calag_1396"/>
    </dbReference>
    <dbReference type="GeneID" id="14212656"/>
    <dbReference type="KEGG" id="clg:Calag_1396"/>
    <dbReference type="eggNOG" id="arCOG00035">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010289_0_2_2"/>
    <dbReference type="OMA" id="NYALYWA"/>
    <dbReference type="OrthoDB" id="101215at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="Alpha_ANH_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022427">
        <property type="entry name" value="MJ0570_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="PTHR12196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039123">
        <property type="entry name" value="Diphthamide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03679">
        <property type="entry name" value="arCOG00187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthami_syn_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="239" mass="27571" checksum="C618E3449120A16A" modified="2013-03-06" version="1">MPKKACSLLSGGKDSTYALHKAVDFGYEISCIASIKPKRNDSYMFHFPFVELTNLQTESMGLKEIHYLLNISGEKEKEVEELYNELYKIKKINDFDTLVIGGIASQYQLKRFEYLARKLNVNLFDPQWGKDPIKYMYELIDYNISFIITQITTYGIPIDFLGIKVDKNVLKKLVDLSKLYGFHIAFEGGEAETFVINAPLFKKGICLEAYRKKISEFEYSLVPKKAFLCDNAEIILNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACL5</accession>
    <name>L0ACL5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA/rRNA cytosine-C5-methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233061.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1460"/>
    <dbReference type="EnsemblBacteria" id="AFZ71164">
        <property type="protein sequence ID" value="AFZ71164"/>
        <property type="gene ID" value="Calag_1460"/>
    </dbReference>
    <dbReference type="GeneID" id="14212720"/>
    <dbReference type="KEGG" id="clg:Calag_1460"/>
    <dbReference type="eggNOG" id="arCOG00973">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_7_0_2"/>
    <dbReference type="OMA" id="EPEENEF"/>
    <dbReference type="OrthoDB" id="32049at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="4">
        <location>
            <begin position="48"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="330" mass="38175" checksum="DB2F54E63C8C29D8" modified="2013-03-06" version="1">MGRNLDIEERIFNYEISSEAKKLAEKYGYSDYIVERYLKLLDNEAIDLLEANEIPMPQTIRCNDFLIRCDELEKRLVNKGFKIKKIPFLPHGYEIISSPYKVGATHEYLMGYYYLQDPGSMLVVYLMNPKKNSFIIDMASAPGGKSSQILQLTKDNVKLVSVELKKDRIKSLRSNLQRMGFSSYIILEIDARKLSLKDADMILLDSPSSGEGIIRKDPKRKKSRPRSDMKKIHMLQFQLLNKAIDMIKPEGEITYAACSTAIEEGEYVIDKILRRNEVDILNTYSPIGEHAFIEFNGVKFDDRIKNCIRLWPHKHGTEGFFICRLKKNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACN4</accession>
    <name>L0ACN4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Rossmann fold enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232804.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1187"/>
    <dbReference type="EnsemblBacteria" id="AFZ70907">
        <property type="protein sequence ID" value="AFZ70907"/>
        <property type="gene ID" value="Calag_1187"/>
    </dbReference>
    <dbReference type="GeneID" id="14212447"/>
    <dbReference type="KEGG" id="clg:Calag_1187"/>
    <dbReference type="eggNOG" id="arCOG04303">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1173322_0_0_2"/>
    <dbReference type="OMA" id="LPRICNE"/>
    <dbReference type="OrthoDB" id="105604at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027510">
        <property type="entry name" value="HMPDK_MptE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39648">
        <property type="entry name" value="PTHR39648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="247" mass="28837" checksum="D63FFC521D95D0AE" modified="2013-03-06" version="1">MSEYLMRYSKELKDILNRIDKIINVYTDYVEPIFKYPRHKELESSMEILPRICNENFYINIINIFEKINNSNICIVGPGDINNNISNCKIFAGPEGGLINALKNNIKFLYITGDLDLSLKLLGEMEFLSEYVFLHVHGDNYTRIRNVYNMNYNIIYTTQVITPYCALPIGVFTDGDRAISLSMLFNAKTIEVYGFDFNNVKCYHKDYCFEEKIEKLNISKEIIKMVAKKLNYNINFYDGKIILINNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACQ8</accession>
    <name>L0ACQ8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor 1-alpha</fullName>
            <shortName evidence="6">EF-1-alpha</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Elongation factor Tu</fullName>
            <shortName evidence="6">EF-Tu</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tuf</name>
        <name evidence="8" type="ordered locus">Calag_1508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233106.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1508"/>
    <dbReference type="EnsemblBacteria" id="AFZ71209">
        <property type="protein sequence ID" value="AFZ71209"/>
        <property type="gene ID" value="Calag_1508"/>
    </dbReference>
    <dbReference type="GeneID" id="14212769"/>
    <dbReference type="KEGG" id="clg:Calag_1508"/>
    <dbReference type="eggNOG" id="arCOG01561">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_2"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="OrthoDB" id="13117at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="4"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="90"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="152"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="436" mass="48643" checksum="F7A08040AFD7FFA2" modified="2013-03-06" version="1">MPEKPHLNLVVIGHIDHGKSTLTGHLLYRLGIVDEKKMRELEEQAKNAGKESFKYAWILDKMKEERERGITIDLSFMKFETRKYVFTIIDAPGHRDFVKNMITGASQADAAMLVVSSRKGEFEAGMSPEGQTREHLLLAKTLGIEQMIVAINKMDAPDVNYDQKRYDEIANTLRKFMKGLGYNIDSIPFVPVSAWTGDNIIERSPNMPWYKGPILVESFDNLQVPPKPVDKPLRLPVQNVYTIPGAGTVPVGRVETGVMKVGDKVIFMPAGVGGEVRSIQMHYQDLQKAEPGDNIGFSVRGVEKNQIKRGDVVGPFDAPPTVADEFVARVFVVWHPSAIAVGYTPVIHIHTATVSAKVTEIISKLDPRTGKEVEKNPQFLKAGDVAMIRFKPIKPVVVEKYSDFPQLGRFAMRDMNRTVGIGIVTEIKPAKVEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACR4</accession>
    <name>L0ACR4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Signal peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Calag_1218</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232834.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1218"/>
    <dbReference type="EnsemblBacteria" id="AFZ70937">
        <property type="protein sequence ID" value="AFZ70937"/>
        <property type="gene ID" value="Calag_1218"/>
    </dbReference>
    <dbReference type="GeneID" id="14212478"/>
    <dbReference type="KEGG" id="clg:Calag_1218"/>
    <dbReference type="eggNOG" id="arCOG01739">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089996_4_0_2"/>
    <dbReference type="OMA" id="WFPEPVI"/>
    <dbReference type="OrthoDB" id="106361at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027245">
        <property type="entry name" value="Sec11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="PTHR10806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="PTHR10806:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="9">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="170" mass="18723" checksum="C7DC53F15A5A66B0" modified="2013-03-06" version="1">MSKKTGKGNKNVLSKGDILFISVIIIIIALGLYAYYFYGFSLVIVDGISMKPTLHTGDIAILYKEPYQDIKIGNIVVYNYDGILIIHRVIGIYYHNGVECFITKGDNNPVPDPGYPQYCGYHTVDGFTSGGIPYYEIKGVILTYNGNTPIIIPYIGSFALAIRGTGSDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACR8</accession>
    <name>L0ACR8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ71219">
        <property type="protein sequence ID" value="AFZ71219"/>
        <property type="gene ID" value="Calag_1519"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1519"/>
    <dbReference type="HOGENOM" id="CLU_2893028_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="62" mass="7236" checksum="7381EE95E8267C79" modified="2013-03-06" version="1">MFGYGFGYGPYYSPFWFIFPLIGFLVMLAFIGIIIWVIVRVVNRESHYMRNHNDNHGCSQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACU8</accession>
    <name>L0ACU8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit Rpo11</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit L</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpo11</name>
        <name evidence="4" type="synonym">rpoL</name>
        <name evidence="7" type="ordered locus">Calag_1159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232777.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1159"/>
    <dbReference type="EnsemblBacteria" id="AFZ70880">
        <property type="protein sequence ID" value="AFZ70880"/>
        <property type="gene ID" value="Calag_1159"/>
    </dbReference>
    <dbReference type="GeneID" id="14212419"/>
    <dbReference type="KEGG" id="clg:Calag_1159"/>
    <dbReference type="eggNOG" id="arCOG04111">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090381_5_1_2"/>
    <dbReference type="OMA" id="PITMARK"/>
    <dbReference type="OrthoDB" id="129321at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_L_2" evidence="6">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="102" mass="11878" checksum="44D55122848A50C1" modified="2013-03-06" version="1">MAGDIKITKTDQGIYKVEIEGEDHTIGNLLSTVLQTLKGVNIAYYEVPHPLENRLIIYMDLDENIDPKDKLIEALQKIKEMNEEFKKKYIEKIKEMNINIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACZ6</accession>
    <name>L0ACZ6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1298"/>
    <dbReference type="EnsemblBacteria" id="AFZ71012">
        <property type="protein sequence ID" value="AFZ71012"/>
        <property type="gene ID" value="Calag_1298"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1298"/>
    <dbReference type="HOGENOM" id="CLU_3210572_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="44" mass="5070" checksum="F1C1F7439DA7318E" modified="2013-03-06" version="1">MKNIVSEVKKPYLSLWYRLAPIKGSNAKTSVEPSPFRAEKRSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD67</accession>
    <name>L0AD67_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome-activating nucleotidase</fullName>
            <shortName evidence="5">PAN</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Proteasomal ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Proteasome regulatory ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Proteasome regulatory particle</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pan</name>
        <name evidence="9" type="ordered locus">Calag_1281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1281"/>
    <dbReference type="EnsemblBacteria" id="AFZ70995">
        <property type="protein sequence ID" value="AFZ70995"/>
        <property type="gene ID" value="Calag_1281"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1281"/>
    <dbReference type="eggNOG" id="arCOG01306">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_2"/>
    <dbReference type="OMA" id="YNMTTFE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022623">
        <property type="term" value="C:proteasome-activating nucleotidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00553">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005937">
        <property type="entry name" value="26S_Psome_P45-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023501">
        <property type="entry name" value="Nucleotidase_PAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01242">
        <property type="entry name" value="26Sp45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="170"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="181"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="392" mass="44161" checksum="E5EFBCBB4B5629E8" modified="2013-03-06" version="1">MIINLSLSDTNKRSNQEDEEEDISYLKERIRYLTQMKISLERDLEYYRQEMTKLLEPPYIEAMLLEVLNDGRAIVKSSTGPNLVVKISNNIDNTKLRPGISVALNNKGSTIVEVLPNIYDPFVEAMEIEDNPGFTFKDVGGLQNQIREIYEVVGLPIVKPELFKSLGIDPPKGVLLYGPPGTGKTLLARSLAGEVKATFIRVVASQFVNKFIGEGARIVREVFKLAREKKPTIIFIDELDAIGSRRIEMGTSGDREVQRTMLQLLAEIDGFDPLDSVKIIAATNRIDLLDPALLRPGRFDRIIEVPLPDKGARLEILKIHTKNMKLKDVNLDYIAQITEGLSGAELKAITTEAGFFAIREKADYVYQDHFIKAVEKVKKRLEEKKQILGIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD87</accession>
    <name>L0AD87_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="11">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">alaS</name>
        <name evidence="14" type="ordered locus">Calag_1302</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="11"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232912.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1302"/>
    <dbReference type="EnsemblBacteria" id="AFZ71015">
        <property type="protein sequence ID" value="AFZ71015"/>
        <property type="gene ID" value="Calag_1302"/>
    </dbReference>
    <dbReference type="GeneID" id="14212562"/>
    <dbReference type="KEGG" id="clg:Calag_1302"/>
    <dbReference type="eggNOG" id="arCOG01255">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_4_0_2"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="OrthoDB" id="7896at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_A">
        <property type="entry name" value="Ala_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022429">
        <property type="entry name" value="Ala-tRNA_lgiase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03683">
        <property type="entry name" value="A-tRNA_syn_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="13">
        <location>
            <begin position="60"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="763"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="704"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="708"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ71015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="906" mass="103990" checksum="71F312322FBEE0F7" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADA6</accession>
    <name>L0ADA6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1324"/>
    <dbReference type="EnsemblBacteria" id="AFZ71035">
        <property type="protein sequence ID" value="AFZ71035"/>
        <property type="gene ID" value="Calag_1324"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1324"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050977_0_0_2"/>
    <dbReference type="OMA" id="GEWAVRI"/>
    <dbReference type="OrthoDB" id="20866at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039651">
        <property type="entry name" value="FixC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43624">
        <property type="entry name" value="PTHR43624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="436" mass="48634" checksum="F029FA18C2EF5F5A" modified="2013-03-06" version="1">MNDLPDIPTKFDVIIVGAGPSGSAAAYILAKKGFKVLLIERGRGLGDKNLYGGRVYAPPIREVWPELDKEAPIQRWVTKERISMVQGEKVITVEYKAEKKISFVSYLTQLTQWMSKKAEDAGALFVTEVTIDEIVMKDGKAVGVRSGPDFIEADVVIDAEGVNRLLLERLGIVERLKPDNIALGVKEILKTGASNIESSFNVGPNEGVAWVIMGDITKGVPGGGFIYTNKDSISMGLVFHLKHAINFIENGQLDEHVSKLIEDFRFHPYFRPYWKDAIISEYGAHLTIEGATHFMPNKFAYPGLLIVGDAAGLLLSTGYTFRGVDYAVYSGKLAAEAVEYARNNGGFTYENLEIYDKNIRRSFMYNELFKHRGAEMLMNSPLMSKYPSILMKVMEKMFEGEFTQETIYDALMQALKEEKVGPFDLISQAFGMVKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADD7</accession>
    <name>L0ADD7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232962.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1356"/>
    <dbReference type="EnsemblBacteria" id="AFZ71065">
        <property type="protein sequence ID" value="AFZ71065"/>
        <property type="gene ID" value="Calag_1356"/>
    </dbReference>
    <dbReference type="GeneID" id="14212616"/>
    <dbReference type="KEGG" id="clg:Calag_1356"/>
    <dbReference type="eggNOG" id="arCOG01831">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010480_0_0_2"/>
    <dbReference type="OMA" id="YNEESIF"/>
    <dbReference type="OrthoDB" id="40897at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="131"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="302" mass="34103" checksum="42090997DE2FEA6B" modified="2013-03-06" version="1">MILSRFGHDSTIITKDLIIGVEIGIQSPEGLIPIIPKYVSCNKSSWKRHTLNFCRILLEYGPSGISDAIKNSKIKMIYDPIYRTQMPYIKQENILIYNNPKSVFKEIFLNSSNGLRYNEESIFNLINELDIDNIGITGSYALGMQFEGSDIDLVIYGEKNSELFYDIFKNKAKIIECKNSFGGVIINGPCIPWRRGLYKNKAYSWTGVPENIASHCNALNNYNRIEIPNKVKDLNITIPEGQIGALLYPPCVKDVNGRYVISFEYNAGYLLYMGGNLKISGLSNEKIIVIGVREYPGKISTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADG9</accession>
    <name>L0ADG9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1463"/>
    <dbReference type="EnsemblBacteria" id="AFZ71167">
        <property type="protein sequence ID" value="AFZ71167"/>
        <property type="gene ID" value="Calag_1463"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1463"/>
    <dbReference type="eggNOG" id="arCOG01147">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083277_0_0_2"/>
    <dbReference type="OMA" id="VIHGHAH"/>
    <dbReference type="OrthoDB" id="74374at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="12"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="244" mass="28211" checksum="6E946166DCB595A6" modified="2013-03-06" version="1">MAELRSKGFPLIYAASDIHYPHYFKIFKDSLDRLNEEPCLFLFAGDIIDKGKVEGAKFVFESIVKRFNKTKIVATFGNDEWNETWDTLRNQYAYVDWIVDDYKVYLCDNTSIAVIGTPGALDKPTRWQLKNINNIEEIYNERIKKIRELIINTKKSYQRIILLSHYALSKLTLKGENPYSYGELYSSKMEKVILETRPDVAIHGHAHKGTAFAMLQNIPIYNVAIPLVKGVTKIKFSKTIETFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADJ1</accession>
    <name>L0ADJ1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase, FAD-containing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233094.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1495"/>
    <dbReference type="EnsemblBacteria" id="AFZ71197">
        <property type="protein sequence ID" value="AFZ71197"/>
        <property type="gene ID" value="Calag_1495"/>
    </dbReference>
    <dbReference type="GeneID" id="14212755"/>
    <dbReference type="KEGG" id="clg:Calag_1495"/>
    <dbReference type="eggNOG" id="arCOG01064">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030742_5_0_2"/>
    <dbReference type="OMA" id="DGWERHY"/>
    <dbReference type="OrthoDB" id="25371at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="393" mass="43554" checksum="CA99F9473651FBB6" modified="2013-03-06" version="1">MTKKIVIAGGGIGGYISAKRLTEQIKKKNIDAEVLVVNKDGFHYMPPLFFDVAFNYGEPEDTRAPIVNMEKYGIKTAIDEIQKIDAANRTVIGTKGKYQYDYLVVSLGTDMGWNAYPGLDKDGVHNFTLEGALEMRKALSQVKDNSNIVLLVPEFPYRCGIYPYEAAPMLSLYIKQRGKKVKVTLLDPIPAPIMPVPNGGLGPEISRFIKETLDEYGVEYVPNAKLREVDVQKKAVVTSAGEFKYDLLVKVPPPRLPKALENSEGFVFKPDPRWSPAMPRTMRHPQYDDVYMAGEHSLPTIGIGLAGVFVESMAITATGNIIADLTGFAPAQPYSPVTCVGYAGEKGWMGTCEVPFDEQKGMYVPKCYFVGKYTVGRLLKQSFYGGWIDSLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADR3</accession>
    <name>L0ADR3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-ribofuranosylaminobenzene 5'-phosphate synthase</fullName>
            <shortName evidence="1">Beta-RFA-P synthase</shortName>
            <ecNumber evidence="1">2.4.2.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48556"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:82767"/>
            <dbReference type="EC" id="2.4.2.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-RFA-P synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.54" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233077.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1478"/>
    <dbReference type="EnsemblBacteria" id="AFZ71180">
        <property type="protein sequence ID" value="AFZ71180"/>
        <property type="gene ID" value="Calag_1478"/>
    </dbReference>
    <dbReference type="GeneID" id="14212738"/>
    <dbReference type="KEGG" id="clg:Calag_1478"/>
    <dbReference type="eggNOG" id="arCOG01026">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061764_0_0_2"/>
    <dbReference type="OMA" id="WGPTFYG"/>
    <dbReference type="OrthoDB" id="47243at2157"/>
    <dbReference type="UniPathway" id="UPA00065"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004422">
        <property type="entry name" value="RFAP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF6">
        <property type="entry name" value="PTHR20861:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004884">
        <property type="entry name" value="Sugar_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00144">
        <property type="entry name" value="beta_RFAP_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_C" evidence="2">
        <location>
            <begin position="210"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="315" mass="35068" checksum="EB2002B9730DB763" modified="2013-03-06" version="1">MKNEVLISAPSHVHVGNIDLNGNLGRKYGTLGFSLESPRLVLRLKISEKDSINDKDGLNYISLFKQYLDCNKYFEAEILEDIPIHVGLGRTTALALSIGFGINYLCNKKASIDELAKVSNRGNQNSGLGVNSFKHGGFIIDGGVKGNNVAPLIFKGIVPDNLRIVVSLPEKPIKNILEIKKREDEILSNLPIMEESFSSYLSRIVLMKIMPSFIENDFKSFGEGLTEFNSSLGKYWKKYQDSIYCCKETEEIIKRFLDLGAYCACQSSWGPTSYGIFEYNDSIKAAEEIKKLINDLGGGKVWITKVDNIGAFLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADW3</accession>
    <name>L0ADW3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase/AMP-acid ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233137.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1542"/>
    <dbReference type="EnsemblBacteria" id="AFZ71240">
        <property type="protein sequence ID" value="AFZ71240"/>
        <property type="gene ID" value="Calag_1542"/>
    </dbReference>
    <dbReference type="GeneID" id="14212804"/>
    <dbReference type="KEGG" id="clg:Calag_1542"/>
    <dbReference type="eggNOG" id="arCOG04201">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_10_2"/>
    <dbReference type="OMA" id="TPSDWAW"/>
    <dbReference type="OrthoDB" id="3223at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="40"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="435"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="527" mass="59416" checksum="7F11B6A72AC78686" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADX6</accession>
    <name>L0ADX6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gatA</name>
        <name evidence="9" type="ordered locus">Calag_1557</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233152.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1557"/>
    <dbReference type="EnsemblBacteria" id="AFZ71255">
        <property type="protein sequence ID" value="AFZ71255"/>
        <property type="gene ID" value="Calag_1557"/>
    </dbReference>
    <dbReference type="GeneID" id="14212819"/>
    <dbReference type="KEGG" id="clg:Calag_1557"/>
    <dbReference type="eggNOG" id="arCOG01717">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_2"/>
    <dbReference type="OMA" id="EVSCPHF"/>
    <dbReference type="OrthoDB" id="12800at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ71255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="475" mass="52491" checksum="E65B8D45DECF8F57" modified="2013-03-06" version="1">MKKETALSILEGLKNGSIDFEDYALRKLEIIQKKDNVINAYISLDSEDFIREKIMEIKEKLASGKNMKIPGLIVSVKDNISTNFLPTTAASKILENYVPPYNATVVEKILEEGGIIIGKTNLDEFAMGSTTEFSAYGVTKNPWDITRVPGGSSGGSAASLSYGSADLSLGSDTGGSVRLPASYTATVGLKPTYGTISRYGLIPYANSLEQISPMARSVKDVSLILDVIKGYDPRDATSLNFEYREFNEKKFKICVPDEFIEGSENPIKSAIYNLLEKIEGEGIVIEYGRKFDKLNYALSTYYTIAFAEAASNLSRYDGKLYPNYYEGRSYREMSENTRKNYFGFEVKKRILMGIFALSEGFINDYYIAATKGRRIIRDEILKMTNDCIIAGSVSPILPPKIGERINDPLKLYAMDIYTVVANLAGVPALAMPAGFYNGLPIGIQFMAGPYEERKLLELGSFIEDKTGLYGIIAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7M8</accession>
    <name>L0A7M8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231724.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0033"/>
    <dbReference type="EnsemblBacteria" id="AFZ69826">
        <property type="protein sequence ID" value="AFZ69826"/>
        <property type="gene ID" value="Calag_0033"/>
    </dbReference>
    <dbReference type="GeneID" id="14211293"/>
    <dbReference type="KEGG" id="clg:Calag_0033"/>
    <dbReference type="eggNOG" id="arCOG04122">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055846_1_3_2"/>
    <dbReference type="OMA" id="VYVHTRN"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="PTHR12636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ69826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="214" mass="25118" checksum="0A6DE95648D9BCEF" modified="2013-03-06" version="1">MGKIDIIYLESALELIPKEIIKKRKIKSNSSILDINFHYKDMLKLKDFKKRGRPDIIHNSLLNILEKPFVIDGKVDVYMHVYDGRVFKFSNDIRIPKNYDRFKGLMSQLLIYNKVPPNEEKPLIYLVSKNLDEFLNDKKILLLTENGEEHSVDDLINIALEKKMPIGIGAFAHGDFNEKTKKYAYKQIRLYHGYKFKSWDITCFISSKLMEKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7Q5</accession>
    <name>L0A7Q5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231754.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0065"/>
    <dbReference type="EnsemblBacteria" id="AFZ69856">
        <property type="protein sequence ID" value="AFZ69856"/>
        <property type="gene ID" value="Calag_0065"/>
    </dbReference>
    <dbReference type="GeneID" id="14211325"/>
    <dbReference type="KEGG" id="clg:Calag_0065"/>
    <dbReference type="eggNOG" id="arCOG08436">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2204229_0_0_2"/>
    <dbReference type="OMA" id="GMMFYSF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="116" mass="12800" checksum="F841E4600401881A" modified="2013-03-06" version="1">METYKILGIIGLIIVGILTIIISLFALVTPYYFPYGMMGYYGNHYMMFGYSFMMFPLVFFIITAVLALIGLAINDKIAAGILLILASFFSLPLFFGGFGIGFILLLLAGIFALINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7Q8</accession>
    <name>L0A7Q8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231759.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0070"/>
    <dbReference type="EnsemblBacteria" id="AFZ69861">
        <property type="protein sequence ID" value="AFZ69861"/>
        <property type="gene ID" value="Calag_0070"/>
    </dbReference>
    <dbReference type="GeneID" id="14211330"/>
    <dbReference type="KEGG" id="clg:Calag_0070"/>
    <dbReference type="eggNOG" id="arCOG02064">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094970_2_0_2"/>
    <dbReference type="OMA" id="ANIWNAK"/>
    <dbReference type="OrthoDB" id="115129at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032836">
        <property type="entry name" value="DsrE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13686">
        <property type="entry name" value="DrsE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="136" mass="15244" checksum="550A39FB6A216EAD" modified="2013-03-06" version="1" precursor="true">MTEKVSIFMISPTLEKLLSLAVIVSGAVAENMEVYVFLSFAQVAFKKGMPEKYDKIGKDYEEYKQTAANYMMEKKVTWYGMLKDAKSSGKVRIDACSLVADMLKLKKEDFDPLVDNISGVSTFLNEAAKSNVVLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0A802</accession>
    <name>L0A802_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="4">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0176</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231859.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0176"/>
    <dbReference type="EnsemblBacteria" id="AFZ69961">
        <property type="protein sequence ID" value="AFZ69961"/>
        <property type="gene ID" value="Calag_0176"/>
    </dbReference>
    <dbReference type="GeneID" id="14211436"/>
    <dbReference type="KEGG" id="clg:Calag_0176"/>
    <dbReference type="eggNOG" id="arCOG01998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_1_2"/>
    <dbReference type="OMA" id="TWVHRFW"/>
    <dbReference type="OrthoDB" id="7134at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="6">
        <location>
            <begin position="194"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="7">
        <location>
            <begin position="396"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ69961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="561" mass="63418" checksum="3C79559A00DD32AC" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>L0A874</accession>
    <name>L0A874_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enolase</fullName>
            <ecNumber evidence="5">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">eno</name>
        <name evidence="10" type="ordered locus">Calag_0254</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell surface</location>
        </subcellularLocation>
        <text evidence="5">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0254"/>
    <dbReference type="EnsemblBacteria" id="AFZ70036">
        <property type="protein sequence ID" value="AFZ70036"/>
        <property type="gene ID" value="Calag_0254"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0254"/>
    <dbReference type="eggNOG" id="arCOG01169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_2"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="9">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="8">
        <location>
            <begin position="140"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5 7">
        <location>
            <begin position="367"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5 6">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="5">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="429" mass="46549" checksum="F648BB7F354D08A8" modified="2013-03-06" version="1">MDSDFLIREVKGIVALDSRGNPTVKAIVKTNKGIGVGIAPSGASKSSKEAIELRDGGKKWVGMGVNLAVSKLNEEVSQRLINQDSRQQYLIDSLLIALDGTKNKSSLGGNTTTAVSIAVSKAAANTANLELYEYLGGPSARILPTPILNIINGGVHAGNNLAFQEFILIPTGARTFIDAMRMSIEVYKNLKGVISEKYGKTSTNVGDEGGYAPPLNESREAFSLIETAIKKSGYELGTDFHLGMDAASSEFYNKDKKVYKVDGKEFTSSELIDFYESLINEFSIIYLEDPFDEDDFDSFSEITKKLGNKLLIVGDDLYATNVNYLMTGIKKKATNGALVKVNQIGTLTETFDYIRLAKESGIIPVISHRSGDTEDPFIADLAVAVGSGIIKTGAPARSERVSKYNRLIEIENQLGPNAIYLGKEPFVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8P3</accession>
    <name>L0A8P3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome bd-type quinol oxidase, subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Calag_0438</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232104.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0438"/>
    <dbReference type="EnsemblBacteria" id="AFZ70206">
        <property type="protein sequence ID" value="AFZ70206"/>
        <property type="gene ID" value="Calag_0438"/>
    </dbReference>
    <dbReference type="GeneID" id="14211698"/>
    <dbReference type="KEGG" id="clg:Calag_0438"/>
    <dbReference type="eggNOG" id="arCOG02720">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_690019_0_0_2"/>
    <dbReference type="OMA" id="MFRLVFA"/>
    <dbReference type="OrthoDB" id="66445at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="396" mass="44236" checksum="D27A1E3897E72864" modified="2013-03-06" version="1">MVMVSVFWLAFNFGIHIVLVNIIIGLAILVPLFKYLGIKRNDTDLITLSRKMMKWYAVTYGIAGVFGTAFTVFLFSFYPFFTDVIGNLLLVPFGISIVFIALNFFSLIAYWYGWDHWSSTTHNIIGILMGASAVMIPFGFRQVFAFLNEPVGLTFSASNQPYLNVVKAYTNPTFWPIYLKSLDGAITAGMLATMGGFGLLYLINNENKKYFEKSVNMLLLPSLIGLLLMIPLGFWYLMSLSNIPYKFNNIMGGFGWVIGNLGISYNYSWLFALSMILTAIQVLAVIYIFYKGIKGSLISRSTAYSSVIAAASAIGTIESMEMLNAFSQFPRFIASLGNQQIAALPYPWNETLSTALNLTDYNPLAAAPFATFFTSIMMAIMIVILAVFIYVIFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8R4</accession>
    <name>L0A8R4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
            <shortName evidence="1">PGP</shortName>
            <shortName evidence="1">PGPase</shortName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dephosphorylation of 2-phosphoglycolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-phosphoglycolate + H2O = glycolate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58033"/>
            <dbReference type="EC" id="3.1.3.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal SPP-like hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231707.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0013"/>
    <dbReference type="EnsemblBacteria" id="AFZ69809">
        <property type="protein sequence ID" value="AFZ69809"/>
        <property type="gene ID" value="Calag_0013"/>
    </dbReference>
    <dbReference type="GeneID" id="14211274"/>
    <dbReference type="KEGG" id="clg:Calag_0013"/>
    <dbReference type="eggNOG" id="arCOG01213">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_2_0_2"/>
    <dbReference type="OMA" id="DTGYAYH"/>
    <dbReference type="OrthoDB" id="58398at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01419">
        <property type="entry name" value="GPH_hydrolase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006382">
        <property type="entry name" value="PGPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="237" mass="26003" checksum="6155E2611E84F82F" modified="2013-03-06" version="1">MIKYVATDVDGTLTIRRGDVRISIEAINGIRLLESNGIKVSLISGNSLPVTLGLRGYIGASGPAIAENGCIIYFHGYKHICNKTPPDELKDIALKMGLIESWQNKFRFHDLAFFIPRNMDKSKIKDLINEIEKNSNKYGFKVLWSGYALHILPEMGGKGFGVKIASELLGFKEEEVATIGDGENDLDMLNFGILSACPSDASEEVKKTVKYVASKPGGEGFLEIANYILKINNQNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8W7</accession>
    <name>L0A8W7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleic acid-binding protein, contains PIN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231762.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0074"/>
    <dbReference type="EnsemblBacteria" id="AFZ69864">
        <property type="protein sequence ID" value="AFZ69864"/>
        <property type="gene ID" value="Calag_0074"/>
    </dbReference>
    <dbReference type="GeneID" id="14211334"/>
    <dbReference type="KEGG" id="clg:Calag_0074"/>
    <dbReference type="eggNOG" id="arCOG00713">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125353_2_0_2"/>
    <dbReference type="OMA" id="MKIFLDA"/>
    <dbReference type="OrthoDB" id="103027at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="134" mass="15616" checksum="69ED730CFFD59E15" modified="2013-03-06" version="1">MKVFIDTPLLVYLNALSEPNNRVPYENLYFDILTNYKCYTDVLVLDELIYVSKRKYNVPYDLTIDFIESEILPYLTILELGEEDYVKAANLMVKYNIKPSDALHLGVMLSNGITLIVSEDKELSKVNEIERKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8X5</accession>
    <name>L0A8X5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative acyl-CoA transferase/carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231772.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0085"/>
    <dbReference type="EnsemblBacteria" id="AFZ69874">
        <property type="protein sequence ID" value="AFZ69874"/>
        <property type="gene ID" value="Calag_0085"/>
    </dbReference>
    <dbReference type="GeneID" id="14211345"/>
    <dbReference type="KEGG" id="clg:Calag_0085"/>
    <dbReference type="eggNOG" id="arCOG02304">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_2_1_2"/>
    <dbReference type="OrthoDB" id="20007at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="401" mass="44533" checksum="DE89837538316DE6" modified="2013-03-06" version="1">MNSNSLILSGIKVLDFTRAMSGPFATMVLGDLGADIIKVEPPEGDESRSWKPPDINGLSSYFISINRNKRSIVVDLKNEKGKEIIHKIAKKVDVVIENFKPGTANKLGIDYKTISSINPSIIYVSLSAYGQTGPWKDKPGYDLTVMATSGLLSLNGEKDRPPVKYGVPIVDITSGLYAVISILSALYYREKTGIGQYIDLSMYDAQLQILSHQALSYLTTGKNPERLGSAHPNIAPYQVFKAKDGYVVIAVGNDNQWKRMCEVLNMNYLLNDPRFKTNPDRVRNRDALVLEMEKVLENISVKEIIDKLESVGVPVAPVNSVAEALNNEQTKSREMVVEVEHKKIGKIKVPGTPFKFTITPGKIRYPPPLLGENTTEILKEFGFSDGEINDLLKNKVIYENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Y5</accession>
    <name>L0A8Y5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0096"/>
    <dbReference type="EnsemblBacteria" id="AFZ69884">
        <property type="protein sequence ID" value="AFZ69884"/>
        <property type="gene ID" value="Calag_0096"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0096"/>
    <dbReference type="eggNOG" id="arCOG00310">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_2"/>
    <dbReference type="OMA" id="VCTKELC"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="7"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="165" mass="18818" checksum="69E66364339EA072" modified="2013-03-06" version="1">MIIMAELNLGENFLDFSLYNTDLKEVKLSDYINQGKPVVLLFFPGAFTSVCTKELCTFRDKMSLLNKANAVVFGISVDSPFSLAKFKAENKLNFDLLSDYNREVIKLYNVYHEDLSMIGLPKLKEASKRAVFIFDKKGKLAYKWVSDHPGKEPDYDKVVEIVNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Z6</accession>
    <name>L0A8Z6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Calag_0578</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232234.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0578"/>
    <dbReference type="EnsemblBacteria" id="AFZ70336">
        <property type="protein sequence ID" value="AFZ70336"/>
        <property type="gene ID" value="Calag_0578"/>
    </dbReference>
    <dbReference type="GeneID" id="14211838"/>
    <dbReference type="KEGG" id="clg:Calag_0578"/>
    <dbReference type="eggNOG" id="arCOG01068">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_2_2"/>
    <dbReference type="OMA" id="CFDYVKP"/>
    <dbReference type="OrthoDB" id="19112at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="6"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="8">
        <location>
            <begin position="346"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="459" mass="51036" checksum="1D0EA6ED3072559D" modified="2013-03-06" version="1">MNQNEFDVIFIGGGGASYPGAFELAKAGKKVLMIDNKGNLGGDCLYAGCIPSKTVRTKILEFTSTNKEIDPEKIWDEVVKTKEWVQEIRYQQHMEEIREHEPNLTFIKGWATILSPNKVKVEGEENFEAYGKYMVIGTGAEHVILNIQGKDLVLTSDELFAYQKTMKKLPKSIAIIGGGYIGVEVADMLSRLGVEVSIIEMMDRLLPTMPIDLSKAAESRMKEAKVSLYLNSPVASIEKKGEMKVVKANSKNGTIEVEAEEVLMAVGRRPRIKGYGLENLEKEGLKVEKNAIWVSPSLRTTLPNVFATGDVTGKAMLFHAAVKESIIAAKNILIGRDAYRMNYHSVPFTVFTYPEIGMIGYTEEELKSLGIAYDVVDYKLAGDAQSQITNHREGWMKIFLEKETLRILGVQVYAHDAAELMGAFAVALENGLTAKNLAWVCGPHPLTFESINYAMRPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0A968</accession>
    <name>L0A968_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1508 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0698"/>
    <dbReference type="EnsemblBacteria" id="AFZ70443">
        <property type="protein sequence ID" value="AFZ70443"/>
        <property type="gene ID" value="Calag_0698"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0698"/>
    <dbReference type="eggNOG" id="arCOG08876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3002949_0_0_2"/>
    <dbReference type="OMA" id="MPKYEFE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010879">
        <property type="entry name" value="DUF1508"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07411">
        <property type="entry name" value="DUF1508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1508" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="56" mass="6579" checksum="264A1C27B79CA7F2" modified="2013-03-06" version="1">MVMQKYEFEVIEEYFLNGEHRFRLKEKNSNIIVNVSAENVDEAAEKASKMLSNLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A972</accession>
    <name>L0A972_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type Fe3+-hydroxamate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231872.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0191"/>
    <dbReference type="EnsemblBacteria" id="AFZ69974">
        <property type="protein sequence ID" value="AFZ69974"/>
        <property type="gene ID" value="Calag_0191"/>
    </dbReference>
    <dbReference type="GeneID" id="14211451"/>
    <dbReference type="KEGG" id="clg:Calag_0191"/>
    <dbReference type="eggNOG" id="arCOG04233">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_2_8_2"/>
    <dbReference type="OMA" id="AACHINS"/>
    <dbReference type="OrthoDB" id="90656at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="119"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="407" mass="45326" checksum="FF18EBED62CB8292" modified="2013-03-06" version="1" precursor="true">MTQGKLFTLSLVLFLIFLFSISLISFYEIKTLSSEILSLRSSISSMNSSLLLQQNKLNNYLNLTISSINNVSHDLAYEVNNINKTLNEKINVLKIETSFPVLIVDALNKTVYIPYQPHRIVSLDPSSTLDILALGYGKYLVGVDNDSIYYLPYPYNNTIFQLYKNKTVTDIGSTYTGADIEQILALRPDLVIGSEGWGYDNYISEILNQYGIPVLLLPSMNSISDIYKSVLMTGEAIGNGYKASILVYNMSSEIFNITNKVINVKPINVTIIGWINPTYATGGNNFINSLISLANGRNIFSNISGWPVISPEELLNANPSVIIIVSNYFNQTSLYQWLNSSIGNAYLNINAIKNNRVYVISGYYQSIIDEPSVYAPLALKLIAEILYPSNFNVTVPNNINPSNFNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A984</accession>
    <name>L0A984_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="3 10">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Calag_0713</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="3 10"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0713"/>
    <dbReference type="EnsemblBacteria" id="AFZ70458">
        <property type="protein sequence ID" value="AFZ70458"/>
        <property type="gene ID" value="Calag_0713"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0713"/>
    <dbReference type="eggNOG" id="arCOG00786">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1237872_0_0_2"/>
    <dbReference type="OMA" id="YFFETHM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="11">
        <location>
            <begin position="22"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="223" mass="26526" checksum="6FCEA60A51822C81" modified="2013-03-06" version="1">MGGRRETDNNRNKNKAIIYPSELHSYFYCPRVYFFETHMKKKRGFFKRVRLFLGSLFHYTFRLRDIIKHYSYEIPMETDLGSVIIRGRPDAFKIKENSAYVIERKSSKPPYKGAWINDIMQAVAYSVILIREKDLKNVKIEIKYPNKSRVFDLNSELTSMLFKALDEMVLIKYNNILPYAKRGNRCNKCPYRNECFSLDEELESYIDDLIEPGKWIENLNLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0A994</accession>
    <name>L0A994_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodipicolinate synthase/N-acetylneuraminate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231892.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0212"/>
    <dbReference type="EnsemblBacteria" id="AFZ69994">
        <property type="protein sequence ID" value="AFZ69994"/>
        <property type="gene ID" value="Calag_0212"/>
    </dbReference>
    <dbReference type="GeneID" id="14211472"/>
    <dbReference type="KEGG" id="clg:Calag_0212"/>
    <dbReference type="eggNOG" id="arCOG04172">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_5_1_2"/>
    <dbReference type="OMA" id="YYGYGGF"/>
    <dbReference type="OrthoDB" id="65776at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="297" mass="33518" checksum="E27C1C7FB46727E3" modified="2013-03-06" version="1">MELKGVVVPMITPFNSKGEIDYNGLKWLIDYTINNGVNALFPNSTTGEFVHLNEEEQINLVKKTIEFSDKKVPILPGITTNVTNFSISLGKKFIDYGADGLIIMPPFFFKLSENDLYFHFSKIAESLDSNIIIYNNPYTTGTVIPISVYERLVKEFSNVIGVKITYDSFDYIRKTIDRLKSLKKDFYVLTGMAQMFLPVLVIGGDGTVSGLANAFPKLHVDLYKEFINKNFSNAFELNKKILLISKIYDIGFSNSSATKAALELIGSPIKSFVRMPLREESKENKEKIKSIIDELKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9B6</accession>
    <name>L0A9B6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable glycine dehydrogenase (decarboxylating) subunit 2</fullName>
            <ecNumber evidence="3">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Glycine cleavage system P-protein subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Glycine decarboxylase subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Glycine dehydrogenase (aminomethyl-transferring) subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvPB</name>
        <name evidence="4" type="ordered locus">Calag_0721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GcvP family. C-terminal subunit subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232364.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0721"/>
    <dbReference type="EnsemblBacteria" id="AFZ70466">
        <property type="protein sequence ID" value="AFZ70466"/>
        <property type="gene ID" value="Calag_0721"/>
    </dbReference>
    <dbReference type="GeneID" id="14211981"/>
    <dbReference type="KEGG" id="clg:Calag_0721"/>
    <dbReference type="eggNOG" id="arCOG00076">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_5_0_2"/>
    <dbReference type="OMA" id="MHINLHK"/>
    <dbReference type="OrthoDB" id="8883at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00713">
        <property type="entry name" value="GcvPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023012">
        <property type="entry name" value="GcvPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="519" mass="58092" checksum="AB2963E3D1664DB4" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9I3</accession>
    <name>L0A9I3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PKD domain protein,extracellular solute-binding protein, family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0817"/>
    <dbReference type="EnsemblBacteria" id="AFZ70558">
        <property type="protein sequence ID" value="AFZ70558"/>
        <property type="gene ID" value="Calag_0817"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0817"/>
    <dbReference type="eggNOG" id="arCOG01533">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319962_0_0_2"/>
    <dbReference type="OrthoDB" id="6658at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="188"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="910" mass="101665" checksum="FD6E0CE3CB675C4B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9J0</accession>
    <name>L0A9J0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232433.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0795"/>
    <dbReference type="EnsemblBacteria" id="AFZ70536">
        <property type="protein sequence ID" value="AFZ70536"/>
        <property type="gene ID" value="Calag_0795"/>
    </dbReference>
    <dbReference type="GeneID" id="14212055"/>
    <dbReference type="KEGG" id="clg:Calag_0795"/>
    <dbReference type="eggNOG" id="arCOG01143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_0_2"/>
    <dbReference type="OMA" id="HGQFWDM"/>
    <dbReference type="OrthoDB" id="104775at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SER_THR_PHOSPHATASE" evidence="1">
        <location>
            <begin position="96"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="299" mass="35080" checksum="FC41B2DC0C5C8C9E" modified="2013-03-06" version="1">MNVNRKEFLQNLFKTINILEKRPIFEKIESKYPLAIIGDIHGFLDSLDRFKKIAEEVSANKLVFLGDYVDRGHMGVEVLNEIFNLLVDFNDKIVLLRGNHESLDMNMYYGFYEELLSKIGREGLDIINQFYSNLPISIIINDVFFVHGGVPCIDCKNKEDQINLINYFQHLNNIKGKEEYLEFKDNVILQMAWNDPDGSIDWFEPNYMRGDGVYYYGKKAWKKFMEENNVNLIIRGHETVDGFHIWKNDGDFISKIKNNEKFYKDQLYGSVITVFSSRYHLGRAGSIIIYEDEVEFVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9J3</accession>
    <name>L0A9J3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Threonyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0006"/>
    <dbReference type="EnsemblBacteria" id="AFZ69802">
        <property type="protein sequence ID" value="AFZ69802"/>
        <property type="gene ID" value="Calag_0006"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0006"/>
    <dbReference type="eggNOG" id="arCOG00401">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_712936_0_0_2"/>
    <dbReference type="OMA" id="IIYPYAH"/>
    <dbReference type="OrthoDB" id="11656at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015011">
        <property type="entry name" value="Threonyl-tRNA_syn_edit_dom_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08915">
        <property type="entry name" value="tRNA-Thr_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-Thr_ED" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="HGTP_anticodon" evidence="1">
        <location>
            <begin position="364"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="470" mass="52865" checksum="D56E8D93888C1FDA" modified="2013-03-06" version="1">MIHLREIKYWAVEEAIENPPDPPSKYEGNECVAGFISVEEDDTPDLSHEAALELAQHANRFKLNCIVIYPFAHLSPSLAEPNKAINVLKSIEDELKKMGFNVNRAPFGWYKGFSITCPGHPMCELSRTITPPKGPFYIKDQNKLSIQDAINNKLLDSSLLINNPWDNESIGAQEKFGILSDGINNIGKFMIDTFMEFLIKENNEENLEIKHGNHKEIYGIDGLSSIIKSVLDYGRYLKDHGASIQGFIPGSDILLLPKISKKDDFDKEFNNIINGISNKLSEIKASSSEGFNINYDIDYDLNLILYKSRNNGFVLLGGYGNVRGNSLTFIGPIRNIISSLIDYGLILADNGITPSLPFWLSPYQVAIIPVKESHEEYAKNIFNELNSKGIRVYYDPPSKSLGTRIRVAGKSWVPMIVVVGDKEKESNTVNVRKRWKQGSQEVLTLDEFYNEIELLKSEGPLNKYLNPPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9J8</accession>
    <name>L0A9J8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_0832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232470.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0832"/>
    <dbReference type="EnsemblBacteria" id="AFZ70573">
        <property type="protein sequence ID" value="AFZ70573"/>
        <property type="gene ID" value="Calag_0832"/>
    </dbReference>
    <dbReference type="GeneID" id="14212092"/>
    <dbReference type="KEGG" id="clg:Calag_0832"/>
    <dbReference type="eggNOG" id="arCOG00706">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_2"/>
    <dbReference type="OMA" id="KAASPVW"/>
    <dbReference type="OrthoDB" id="9593at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="10">
        <location>
            <begin position="7"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="640" mass="70561" checksum="5EB8BA43AF547D0C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9K8</accession>
    <name>L0A9K8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232480.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70583">
        <property type="protein sequence ID" value="AFZ70583"/>
        <property type="gene ID" value="Calag_0842"/>
    </dbReference>
    <dbReference type="GeneID" id="14212102"/>
    <dbReference type="KEGG" id="clg:Calag_0842"/>
    <dbReference type="eggNOG" id="arCOG13916">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130314_0_0_2"/>
    <dbReference type="OMA" id="MAFVIME"/>
    <dbReference type="OrthoDB" id="118547at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="174" mass="18679" checksum="A30AC299FA744D69" modified="2013-03-06" version="1">MGALANTAMNTLFWEAGVMTLIIGFVNIGIGGNKINPKDFGIVILSGALMETLALSFVIEDRAVFDATVAAAFVLLLWMISIALILGGTNLYVIQHALWFTGILFFGFATYTAYLHLIFITIILYLLVPVTVFLSLHGYTGKAVYAKIAGYCSAIDGFLFLVLAFTGAIGVVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9P1</accession>
    <name>L0A9P1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0347"/>
    <dbReference type="EnsemblBacteria" id="AFZ70124">
        <property type="protein sequence ID" value="AFZ70124"/>
        <property type="gene ID" value="Calag_0347"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0347"/>
    <dbReference type="eggNOG" id="arCOG00751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_3_2"/>
    <dbReference type="OMA" id="RKEWYAN"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="109"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="356" mass="39498" checksum="8CAF83E72C50F482" modified="2013-03-06" version="1">MGGWDIKLWQYVLRRVLLFIPTLLGLTIIVFVLIHIGGTNKLLAMYLSPRLTGAARQQIIAELDQKFHFNDPIYIQYFYWLGQIFEGNWGITNTPIFSGPVTQAIEIFFPNTLMLTIVAAILIWFISIPLGVHTAVNRDKPSDNTIRVASLTFYAMPWYLIGIVLIIIFAVWLKILPISGTVNPSLVAGLSWYKNGISYPTHVLLIDALIHGDFVVAGNAFLHLIMPSLTLALGVMAALVRLMRGTMLETLDQDFVNFARAKGVPEKVVINLYAKNNALLPVITNFGYLVAGLLGGVVVIEDVFSYPGIGMWLTDAMINNDMGGIMGGTLLFGIILVVTSLILDLIYAKIDPRIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9R9</accession>
    <name>L0A9R9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HIT family hydrolase, diadenosine tetraphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231703.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0009"/>
    <dbReference type="EnsemblBacteria" id="AFZ69805">
        <property type="protein sequence ID" value="AFZ69805"/>
        <property type="gene ID" value="Calag_0009"/>
    </dbReference>
    <dbReference type="GeneID" id="14211270"/>
    <dbReference type="KEGG" id="clg:Calag_0009"/>
    <dbReference type="eggNOG" id="arCOG00419">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_1_2_2"/>
    <dbReference type="OMA" id="YNPGHVM"/>
    <dbReference type="OrthoDB" id="93754at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="3">
        <location>
            <begin position="38"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2">
        <location>
            <begin position="132"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ69805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="181" mass="20582" checksum="93B8DA1754D0C692" modified="2013-03-06" version="1">MEWAEKWYDNLWAPWRMSYIKNFSGTKNEEKNEKNKCIFCEAQKLDMKEALVVFKGKFSFIILNKFPYNSGHLMIAPYRHVGNLTELNDDEMLEISKLIKVSIDALTKAYKPEGFNIGVNIGEAAGAGVPGHVHIHIVPRWKGDANYITIIGGVKVVPQSLEETYNILKPLIEEVSRNLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9S7</accession>
    <name>L0A9S7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3-dehydroquinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Calag_0109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231795.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0109"/>
    <dbReference type="EnsemblBacteria" id="AFZ69897">
        <property type="protein sequence ID" value="AFZ69897"/>
        <property type="gene ID" value="Calag_0109"/>
    </dbReference>
    <dbReference type="GeneID" id="14211369"/>
    <dbReference type="KEGG" id="clg:Calag_0109"/>
    <dbReference type="eggNOG" id="arCOG00983">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_0_1_2"/>
    <dbReference type="OMA" id="YGVIWDA"/>
    <dbReference type="OrthoDB" id="45841at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="55"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ69897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="347" mass="39283" checksum="E9A869CADBEB0524" modified="2013-03-06" version="1">MIYKLNDKEVNIIVGKNLLNSLKIDNNKKYFIIYQDTINDKIKSLISNITHFEIYKVPDREKAKDIEVALDIIKQMVSKEFTRKDAIISFGGGTVSDLSGFVASIFMRGIDLINIPTTLLSMVDASIGGKNGVNFHNIKNVIGTFYQPSMIIIDTSLLDSLPYDEILNGLGEVIKYSIIMDKDLYYYLLNNKEKILKLDDESISYIIRKSIDDKMKIVIRDEKETSGLRTVLNFGHTIGHAIESGSKLKIMHGFAISYGMICETKLGVDLKLISDEIYENVENIINLYDIKINKNEVDLNNALNSLKSDKKRTGNKIIIPLPVDIGKYQLFPIEIEKIEKAIVKCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9X8</accession>
    <name>L0A9X8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">bPH_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0156"/>
    <dbReference type="EnsemblBacteria" id="AFZ69942">
        <property type="protein sequence ID" value="AFZ69942"/>
        <property type="gene ID" value="Calag_0156"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0156"/>
    <dbReference type="eggNOG" id="arCOG13268">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1340680_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027783">
        <property type="entry name" value="Bacterial_PH-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10882">
        <property type="entry name" value="bPH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_5" evidence="2">
        <location>
            <begin position="93"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="204" mass="23784" checksum="F675AC7C18735891" modified="2013-03-06" version="1">MLTGGLTIKIKTLIKQILIGRKLSQKIRVSFQRNTIAIFAFLIAFIIALDSYLVLAKYHNLIQRGEEYLVFILLIPFVILLLAFLTLFNSYFTISNDKIEIHSYIYHEKINRDDIEKIVFTNNLDPGYLVSFRITGYNFPGTQFGWFRLTNGKKAFLLISGKVNNILIFELKDGKVFMISGNFLEKLINYLNIYKWDVIKNMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Y7</accession>
    <name>L0A9Y7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232132.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0468"/>
    <dbReference type="EnsemblBacteria" id="AFZ70234">
        <property type="protein sequence ID" value="AFZ70234"/>
        <property type="gene ID" value="Calag_0468"/>
    </dbReference>
    <dbReference type="GeneID" id="14211728"/>
    <dbReference type="KEGG" id="clg:Calag_0468"/>
    <dbReference type="eggNOG" id="arCOG00062">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_8_2"/>
    <dbReference type="OrthoDB" id="66517at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="256" mass="29306" checksum="7BBF7A416EA1D19F" modified="2013-03-06" version="1">MEKLKITIVQFRRRPLIDENLWNAISLVKNKTDIIVFSENWLSNKPIALNDYSYYLEKIGNILDANILGGIQYVYDNGYIKSVGMGYIDGKLVKICEKINPSKAVGERNYLVEGKYVKPIKVNSWYIGCVACVDIFYPEISRIHALNNADILYNPASISNESLALWHSTLQTRAAENVVYSIGVNNTNTVYPDNRITAGGSIVFNPHGDKIIELGSDDEAIDIILDYDYFNYVKNRWAFRDDLIKKYSIFYKNNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA25</accession>
    <name>L0AA25_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Adenine deaminase</fullName>
            <shortName evidence="5">Adenase</shortName>
            <shortName evidence="5">Adenine aminase</shortName>
            <ecNumber evidence="3 5">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ade</name>
        <name evidence="8" type="ordered locus">Calag_0510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="3 5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0510"/>
    <dbReference type="EnsemblBacteria" id="AFZ70274">
        <property type="protein sequence ID" value="AFZ70274"/>
        <property type="gene ID" value="Calag_0510"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0510"/>
    <dbReference type="eggNOG" id="arCOG00693">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027935_0_0_2"/>
    <dbReference type="OMA" id="TDHECFT"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01518">
        <property type="entry name" value="Adenine_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01178">
        <property type="entry name" value="ade"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="74"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Adenine_deam_C" evidence="7">
        <location>
            <begin position="421"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="594" mass="65884" checksum="42A0E1B592427A1E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA26</accession>
    <name>L0AA26_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231880.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ69982">
        <property type="protein sequence ID" value="AFZ69982"/>
        <property type="gene ID" value="Calag_0200"/>
    </dbReference>
    <dbReference type="GeneID" id="14211460"/>
    <dbReference type="KEGG" id="clg:Calag_0200"/>
    <dbReference type="HOGENOM" id="CLU_616237_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="444" mass="50535" checksum="1A3C95EA756E7B36" modified="2013-03-06" version="1" precursor="true">MYSKNRKNAYIIIIVALILAVIFFPFMAKINSVVSTNESSMLPKNVESIEVMNIVNKESNSSNQSNVIYLISGVPINIETYYKLKGINIRGESFLKILNTTYNDIENSSSFLLNTSIQISNGIKNLWNETINLTEKLNSLKDSILQISSLIRNSDYIYYNYYQTGENLSKAYSEIISTLILYGNNTKTISSLYEQIYFNALRSEYALYNKTNAYETMNLTKQDILIVLENSPYINNISSPSPLLIEALFKYVLLNGGPKAFNNMMANNFTYQVIYNELNSSNELSAVPLLKTYGNEFYNISSKYPINFIINNLTLQNQYKLYYMLNSISNYSSIETFKEILSFIPIENEEESTIINGIGMQYAITGFNNSKLGSIVQQTTYDILSQRLPREIAIGLSSFISNDSFNAEIASIYAAKTILYYLPSSYQNYSKLISIYIPKNFVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA43</accession>
    <name>L0AA43_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="1">5.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0533"/>
    <dbReference type="EnsemblBacteria" id="AFZ70294">
        <property type="protein sequence ID" value="AFZ70294"/>
        <property type="gene ID" value="Calag_0533"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0533"/>
    <dbReference type="eggNOG" id="arCOG01122">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_1_1_2"/>
    <dbReference type="OMA" id="YDWDEVN"/>
    <dbReference type="OrthoDB" id="98657at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="PTHR11934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="230" mass="25689" checksum="52F16F31C9D1B1D8" modified="2013-03-06" version="1">MHCDPKKEAAKGALELIKEFISNYEIIGLGTGSTTQAFIMESKELLKNKKLISSSNSTSLFLSSLGLETKEFPLLNSNYIYIDGADEVTKQGYMIKGRGGALLGEKILAYSSSLNIFVVSEEKLVNKLGEKRPVPIEVIPKAYPYLLNIFKRNNLRSELRQCNAKDGPIISDWGGYIIDVYTGPMDDPRYYDNMLRSFPGVVETGIFMGLSDYIVIGKESCGYDVIRIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA76</accession>
    <name>L0AA76_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD-dependent protein deacetylase, SIR2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232705.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1086"/>
    <dbReference type="EnsemblBacteria" id="AFZ70808">
        <property type="protein sequence ID" value="AFZ70808"/>
        <property type="gene ID" value="Calag_1086"/>
    </dbReference>
    <dbReference type="GeneID" id="14212346"/>
    <dbReference type="KEGG" id="clg:Calag_1086"/>
    <dbReference type="eggNOG" id="arCOG04248">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_0_2"/>
    <dbReference type="OMA" id="EQCKKCR"/>
    <dbReference type="OrthoDB" id="82426at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="255" mass="28703" checksum="EA3B8B2715B63FAF" modified="2013-03-06" version="1">MDYIREIAEKLIKANFAVVLTGAGISTGSGIPDFRGPQGIWRVYDPNLFHISYFYENPLDTWKLFKDNMYEKIKDAKPNRAHYSLARLEELNIIKAVITQNIDNLHQKAGSKKVIELHGNMKFAICTQCNRKFDIETAFKEVKENKVPLCPYCGGLLKPDVIFFGEPLPQKELREAFELASESDLFLVLGSSLAVSPANQLPIIAKSNGADLIIINMGETEIDNYADIKVEGRVEDIFPKICKKIEEMIASLSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA82</accession>
    <name>L0AA82_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase family protein with metal-binding cysteine cluster</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232232.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0576"/>
    <dbReference type="EnsemblBacteria" id="AFZ70334">
        <property type="protein sequence ID" value="AFZ70334"/>
        <property type="gene ID" value="Calag_0576"/>
    </dbReference>
    <dbReference type="GeneID" id="14211836"/>
    <dbReference type="KEGG" id="clg:Calag_0576"/>
    <dbReference type="eggNOG" id="arCOG00555">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000809_3_2_2"/>
    <dbReference type="OMA" id="CIQSPKC"/>
    <dbReference type="OrthoDB" id="796at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="73"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="275"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="752" mass="85097" checksum="BDB98E78E57D734F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA85</accession>
    <name>L0AA85_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lactate dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232715.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1096"/>
    <dbReference type="EnsemblBacteria" id="AFZ70818">
        <property type="protein sequence ID" value="AFZ70818"/>
        <property type="gene ID" value="Calag_1096"/>
    </dbReference>
    <dbReference type="GeneID" id="14212356"/>
    <dbReference type="KEGG" id="clg:Calag_1096"/>
    <dbReference type="eggNOG" id="arCOG01755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_2"/>
    <dbReference type="OMA" id="KMKPNCI"/>
    <dbReference type="OrthoDB" id="36410at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="16"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="110"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="335" mass="37562" checksum="BF7FB4C118AB2F71" modified="2013-03-06" version="1">MYKLFMTREIPFPATEKIKKMFDVTIWPKYTPPSKEDIINNAKGVDALVTTLEDKITCEIIEKLSPNLKIIAQYAVGFDNVDLECATKHGVYVTNTPDVLTDATADVAWALILSVSRRIVESDKFVRSGKWYTLGSAWHPTLMLGYDVYGKTIGIVGGGRIGYAVAKRAKGFDMNILYSSRSRHKEMEELGAKYVDMNTLFKESDIVSLHVPLTKETANMVNENLLRLMKKTSILINTARGKVVDLDALYKALKEGWIAGAGLDVYPSEPLDPRHPITTLDNVVLLPHIGSATHETRAKMADLVYKNLEMFFNGEIPLTLVNKDVLNIRRPEKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA89</accession>
    <name>L0AA89_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0175"/>
    <dbReference type="EnsemblBacteria" id="AFZ69960">
        <property type="protein sequence ID" value="AFZ69960"/>
        <property type="gene ID" value="Calag_0175"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0175"/>
    <dbReference type="eggNOG" id="arCOG01381">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_913994_0_0_2"/>
    <dbReference type="OMA" id="RYARRIM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="304" mass="35754" checksum="7646F2E6452482C9" modified="2013-03-06" version="1">MVKVARRKILGRRGVFILSNFISNILTIPSFVDSRREGKEKGISAVVLSYNEPDWIDLSLKSISNLVDEYIVVDSSNDETTQIIEELSSKLPIKLIKQPPLGQHIARNEALKHVNYKYVLIWDADFIATDKLIEKIKDFVYNSDDKFYYLVYYPLISFCGDLSHRCRDKYHVEHWLFTWSKKLKYLWDGRIEYLYSPIYYKRVDLSYDPLGYHMRSVKKPERVALSTLFYQTNYYDVKNKKGEEEANKLLEETGLKLYNTKDLKEIGLKIMKEMTINKPCFDYKQLPKEIIDRAIKNGIPLGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAB5</accession>
    <name>L0AAB5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotetramer of one alpha, one beta, one delta and one gamma chain.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232708.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1089"/>
    <dbReference type="EnsemblBacteria" id="AFZ70811">
        <property type="protein sequence ID" value="AFZ70811"/>
        <property type="gene ID" value="Calag_1089"/>
    </dbReference>
    <dbReference type="GeneID" id="14212349"/>
    <dbReference type="KEGG" id="clg:Calag_1089"/>
    <dbReference type="eggNOG" id="arCOG01604">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_1_1_2"/>
    <dbReference type="OMA" id="HDDRCIR"/>
    <dbReference type="OrthoDB" id="125632at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011898">
        <property type="entry name" value="PorD_KorD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43724">
        <property type="entry name" value="PTHR43724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02179">
        <property type="entry name" value="PorD_KorD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="106" mass="11965" checksum="10A14CDFAB321134" modified="2013-03-06" version="1">MEKLVSYTEMAPGGIVVNPGNSLEYKTGDWKVLIPVINQETCTRCRICWYVCPDNAIIELDKEYTTKKNRKYKVSYDVNSDFCKGCGMCAQECPVKAIEMVPVEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAC6</accession>
    <name>L0AAC6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1141"/>
    <dbReference type="EnsemblBacteria" id="AFZ70863">
        <property type="protein sequence ID" value="AFZ70863"/>
        <property type="gene ID" value="Calag_1141"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1141"/>
    <dbReference type="eggNOG" id="arCOG00350">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_1_2_2"/>
    <dbReference type="OMA" id="EWQTGRF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="2">
        <location>
            <begin position="27"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="288" mass="33075" checksum="4F4890B280F703FE" modified="2013-03-06" version="1">MISLLDFKRLDFCNINKAGIGMILASWRDIAKTIKTSDVVIEVLDIRDPISTRSKRVEEIANSLNKNLIILLNKADLVPYNIAEKWKEKFTLEGFDTIFYSVWRKKDRKHLLEMLDKYSKGNETFYSLIGYPKTGKSSIINSLKGKKSAPTSPLPGSAGYTKSFTIYKIKNGIYVLDSPGVMPIEGGFPESIIRGKAIDELNDPVRPAVALIEKILKYNPNAFLNSYKINERDPYKILEELAYKRMWIYKKTKEPNIDEAAKAIIRDYHKAKIEFFVYPEENIEMSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAD8</accession>
    <name>L0AAD8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="7">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">t(6)A37 threonylcarbamoyladenosine biosynthesis protein Kae1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA threonylcarbamoyladenosine biosynthesis protein Kae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">kae1</name>
        <name evidence="9" type="ordered locus">Calag_0223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="7">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="7"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231903.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0223"/>
    <dbReference type="EnsemblBacteria" id="AFZ70005">
        <property type="protein sequence ID" value="AFZ70005"/>
        <property type="gene ID" value="Calag_0223"/>
    </dbReference>
    <dbReference type="GeneID" id="14211483"/>
    <dbReference type="KEGG" id="clg:Calag_0223"/>
    <dbReference type="eggNOG" id="arCOG01183">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_2_2_2"/>
    <dbReference type="OMA" id="MRIMCEE"/>
    <dbReference type="OrthoDB" id="34679at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022449">
        <property type="entry name" value="Kae1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="PTHR11735:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="8">
        <location>
            <begin position="27"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="129"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="334" mass="36679" checksum="CE4440CF3EEA5EF3" modified="2013-03-06" version="1">MITLGIESTAHTFGVGIFSESKGIIGESRKNYIPKKGGILPREVASFFSDVAGEAIKEALEQAKISINDIDGIGVALGPGMGPQLRVGASVARALAVKYNKPLIPVNHAIAHLEIARYLTNMRDPVILYVSGGNSIVTTYVDGKYRIFGETLDIALGNLLDTFAREVKLGPPYIVKGDHVVDICAENGKFIKGFPYVVKGQDVSYSGLLTLAIRLKEKGYNLKDICFTVREIAFSSITEVTERCVAHTNKKQIILTGGVAANKLLNDKLTKMAENQNASYKPVPFKYSGDNGVMIALTALLELKHNITIEPERAFINQRWRIDEVEIPWYYSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAD9</accession>
    <name>L0AAD9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1114"/>
    <dbReference type="EnsemblBacteria" id="AFZ70836">
        <property type="protein sequence ID" value="AFZ70836"/>
        <property type="gene ID" value="Calag_1114"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1114"/>
    <dbReference type="eggNOG" id="arCOG04224">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157709_0_0_2"/>
    <dbReference type="OMA" id="IPELEVW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="126" mass="14134" checksum="CD2DC2A79403C304" modified="2013-03-06" version="1">MSEENDSKKVSKDVRPEKADLSKALSIIPPASSLKEKGKKIVERRLRISYDEGVDKGNVKLSKKLASELGIQKKLEMVIASKKKLVFDSQIDESIQEETKVFVNPDEMKEKGVADNSIVTIRAFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAE0</accession>
    <name>L0AAE0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lactate dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0303"/>
    <dbReference type="EnsemblBacteria" id="AFZ70082">
        <property type="protein sequence ID" value="AFZ70082"/>
        <property type="gene ID" value="Calag_0303"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0303"/>
    <dbReference type="eggNOG" id="arCOG01755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_2"/>
    <dbReference type="OMA" id="CRGMPSN"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="8"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="104"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="334" mass="38517" checksum="A55D4ECDECECFF16" modified="2013-03-06" version="1">MLSTMRLSDDMVSLLKSKEIKPILPEERIANREWIEKNIDNATSILLTFINFDKELIDKAKNLKVIIATSSGYDHIDVEYAEKKGICVANQPEAIAHSVAEHAIGMTISLLKKIVQGDRYVWDRQWKEFPYFLTGNLLRNKDVAVIGMGRIGVLILSYLRNFKIGKILYYSRKRKPEIEILLKAEPASLERIFKQSDIIYLTLPYNKETQNLINQDLLMSMKKGSILISLGRGKVLKTDDIVSTLNKRNDIMFGLDVFDSEPLPPDSPLFNNKFRDNLLLTPHMSGPSKETSHITIYMALKQLIHYYEKGSVWNPVNNVCKESHDIENYWEYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAE5</accession>
    <name>L0AAE5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232780.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1162"/>
    <dbReference type="EnsemblBacteria" id="AFZ70883">
        <property type="protein sequence ID" value="AFZ70883"/>
        <property type="gene ID" value="Calag_1162"/>
    </dbReference>
    <dbReference type="GeneID" id="14212422"/>
    <dbReference type="KEGG" id="clg:Calag_1162"/>
    <dbReference type="eggNOG" id="arCOG00910">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074702_1_0_2"/>
    <dbReference type="OMA" id="DVVYSIH"/>
    <dbReference type="OrthoDB" id="119044at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="211" mass="24477" checksum="2F4971A3366CF94C" modified="2013-03-06" version="1">MNKNEKYINAKVFLEKTLPSITNPIRDLEQYNTPSEIILDMLNHAYISNIIQDSTVLDLGSGTCRIALASLIFGASKAIGLEIDDRFFKYCLYGEETFGLRGRLLLIKTFINENLGLIRKNHIDLIIMNPPFGVWNRNADKRFLEYAFSLNPKRIYSVLKSGNLNFHESLSNKWGYRLRLLNTREFPIPASMTYHKSRIRRVKVDVLLFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAF5</accession>
    <name>L0AAF5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232753.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1134"/>
    <dbReference type="EnsemblBacteria" id="AFZ70856">
        <property type="protein sequence ID" value="AFZ70856"/>
        <property type="gene ID" value="Calag_1134"/>
    </dbReference>
    <dbReference type="GeneID" id="14212394"/>
    <dbReference type="KEGG" id="clg:Calag_1134"/>
    <dbReference type="HOGENOM" id="CLU_1140529_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="243" mass="27714" checksum="51417BB4C69C8FF1" modified="2013-03-06" version="1">MKILFFILILIMISLPIYNLESIPILLNNPSSSIEIKNNSISSFNNGIYSIYYNNIYEGSLVLNGAYKILIYNINTNLLIIFLKNINIKIKNLTFYNSTPYLLLNTNDSNLKILNISIGKYGILNIPGINETYNINGSILEINLNNLIGKTISFSKSSWLIYQFSDNSSLDVVFGIITTNKTIITNPENLSNVTILNSSNIFSENKEDYNKFYMIIYYSLFLLSLLTLVLALVTSNAKWERHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAH0</accession>
    <name>L0AAH0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231938.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0259"/>
    <dbReference type="EnsemblBacteria" id="AFZ70040">
        <property type="protein sequence ID" value="AFZ70040"/>
        <property type="gene ID" value="Calag_0259"/>
    </dbReference>
    <dbReference type="GeneID" id="14211519"/>
    <dbReference type="KEGG" id="clg:Calag_0259"/>
    <dbReference type="eggNOG" id="arCOG03704">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_712911_0_0_2"/>
    <dbReference type="OMA" id="ALAMSHW"/>
    <dbReference type="OrthoDB" id="49772at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="387" mass="43007" checksum="254A57CC11C1E5D0" modified="2013-03-06" version="1" precursor="true">MDSKLIGVTVVAVILLIAAAGLGYMYSATSSSYNSLKSQYNQISQNLTNTNNKLNELSSELSSINSSYNSLSSSYKKLALQFNGQQPQVVLALAMSHWNDIAIENASLVIQEYAPNAVLHWIGGPLAGTYNGVSQITNVWNKFFNTYETVYWYTIIPPSVTQINSTTYQVTGYAQFFVAPTSDPLNLLVLNVTEMLTYQYINGQYMLTNEVWKVMPLTLSDVIAGYPSQEYIQSQLVLALAMSHWNDIAIENASLVIQEYAPNAVLHWIGGPLTGNYTGIEQINATWNKFNSLYEYVTWYSLVPPSVVIHGTSAMAYAPLQFVVFPFPTSSNPTPHELVLNVTEELYYNYNTSTSSWQIVNEYWIVHPIPVSDVAPGYTGSVYNASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAJ3</accession>
    <name>L0AAJ3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA family ATPase, CDC48 subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1180"/>
    <dbReference type="EnsemblBacteria" id="AFZ70901">
        <property type="protein sequence ID" value="AFZ70901"/>
        <property type="gene ID" value="Calag_1180"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1180"/>
    <dbReference type="eggNOG" id="arCOG01308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_2"/>
    <dbReference type="OMA" id="IPMPDKK"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="4">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="3">
        <location>
            <begin position="105"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="213"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="489"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="723" mass="81388" checksum="F6442236B78AC26F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAJ5</accession>
    <name>L0AAJ5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="9">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Calag_1219</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232835.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1219"/>
    <dbReference type="EnsemblBacteria" id="AFZ70938">
        <property type="protein sequence ID" value="AFZ70938"/>
        <property type="gene ID" value="Calag_1219"/>
    </dbReference>
    <dbReference type="GeneID" id="14212479"/>
    <dbReference type="KEGG" id="clg:Calag_1219"/>
    <dbReference type="eggNOG" id="arCOG04276">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_2_1_2"/>
    <dbReference type="OMA" id="PLYPFES"/>
    <dbReference type="OrthoDB" id="4783at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8 9" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_lgN" evidence="10">
        <location>
            <begin position="74"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="11">
        <location>
            <begin position="150"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="11">
        <location>
            <begin position="305"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="998" mass="113385" checksum="9ABBA6C3A7C6275F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAK4</accession>
    <name>L0AAK4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231968.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0290"/>
    <dbReference type="EnsemblBacteria" id="AFZ70070">
        <property type="protein sequence ID" value="AFZ70070"/>
        <property type="gene ID" value="Calag_0290"/>
    </dbReference>
    <dbReference type="GeneID" id="14211550"/>
    <dbReference type="KEGG" id="clg:Calag_0290"/>
    <dbReference type="eggNOG" id="arCOG01458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_2"/>
    <dbReference type="OMA" id="HQLCRAW"/>
    <dbReference type="OrthoDB" id="56644at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="340" mass="37649" checksum="F9B43B71C4631163" modified="2013-03-06" version="1">MRAIYFNSHGDIDVLKYGEFEDPKINRGEALIKVEYSSINRMDTLIRKGYPGINIPLPHIPGVDLYGKVIDIDDNSDISPGDFVIANTVYGCGHCDFCLQGKENMCNQWKMIGFHINGAHAELIKVPSKTLIKVKGDGEKLGVSPLSLSIAWTSLVTIGKIKKDDFVLIHGASGGVGMFSIKIAKLFGAKTIATTRSVEKAKILKSIGADYVIVSTEEDVKNRVLELTNKNGVDIVVDYIINPTLQTSLDVTKTNGKIVIFGFLGGNTFAINWQKFYLKHLEIYGTHNSSKLELKNAIKYVENGEIEPYISKTVNLEYVKEGHKIIENNDIIGKISVRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAK5</accession>
    <name>L0AAK5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232357.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0714"/>
    <dbReference type="EnsemblBacteria" id="AFZ70459">
        <property type="protein sequence ID" value="AFZ70459"/>
        <property type="gene ID" value="Calag_0714"/>
    </dbReference>
    <dbReference type="GeneID" id="14211974"/>
    <dbReference type="KEGG" id="clg:Calag_0714"/>
    <dbReference type="eggNOG" id="arCOG00441">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_898986_0_0_2"/>
    <dbReference type="OMA" id="ALYEWKY"/>
    <dbReference type="OrthoDB" id="62125at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="58"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="310" mass="35418" checksum="B108B29B56A58A78" modified="2013-03-06" version="1">MSLDNDIIEKKVYETYAQIATESTMVRNVKEAVKILEKNYKLIINEDIVRLVYASFLNGRPVLFEGPPGTGKTEIGEALLELWSGKKGFLLPCSENYDEYKVIGDFHPLMAMKIGFTEESFVPRILLAAMILDVGVLVDEIRRSSDEFQNLLLDIIDKRRIVVPELKRVFKSKGSGFQVILTSNPEDVAQNELSDAFLRRVIRIKFDYPDIETERKIIKIRSFDKPLVSEELINLVLKTINKLRKSNLLHKPGTDESVSWVKLAQSIAKLENEDVVKIKHIKEAATSLLSKRQEDEELITSVINDVFSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAK9</accession>
    <name>L0AAK9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232850.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1236"/>
    <dbReference type="EnsemblBacteria" id="AFZ70953">
        <property type="protein sequence ID" value="AFZ70953"/>
        <property type="gene ID" value="Calag_1236"/>
    </dbReference>
    <dbReference type="GeneID" id="14212496"/>
    <dbReference type="KEGG" id="clg:Calag_1236"/>
    <dbReference type="eggNOG" id="arCOG03871">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1763782_0_0_2"/>
    <dbReference type="OMA" id="YLWFAGY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="147" mass="15844" checksum="184B5F121B039669" modified="2013-03-06" version="1" precursor="true">MSKKRSVSEIVAVVMLIIVAISASTLLYIWLNSVIGTMHYNNPALYEKISISAGNITKTSNGNYTAYAYVQNSGSPVTISSVVVLYYNNSLIYFNNTPSGDLNIKPNSVGLVYASNNTKVKVPSGSPVIIEVITANGVKATYQTTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAM0</accession>
    <name>L0AAM0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ribosome biogenesis protein Nop10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nop10</name>
        <name evidence="8" type="ordered locus">Calag_0373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232045.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0373"/>
    <dbReference type="EnsemblBacteria" id="AFZ70147">
        <property type="protein sequence ID" value="AFZ70147"/>
        <property type="gene ID" value="Calag_0373"/>
    </dbReference>
    <dbReference type="GeneID" id="14211633"/>
    <dbReference type="KEGG" id="clg:Calag_0373"/>
    <dbReference type="eggNOG" id="arCOG00906">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196480_0_0_2"/>
    <dbReference type="OMA" id="FRIRKCP"/>
    <dbReference type="OrthoDB" id="130364at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00803">
        <property type="entry name" value="Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023532">
        <property type="entry name" value="Nop10_arc-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="SSF144210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="55" mass="6774" checksum="5EF68DBC90D9C159" modified="2013-03-06" version="1">MRWLLRKCIKCNRYTLSQERCPYCGGQLKVPHPPKYSPNDKYIEYRYKLKYKTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAM6</accession>
    <name>L0AAM6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Calag_1217</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232833.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1217"/>
    <dbReference type="EnsemblBacteria" id="AFZ70936">
        <property type="protein sequence ID" value="AFZ70936"/>
        <property type="gene ID" value="Calag_1217"/>
    </dbReference>
    <dbReference type="GeneID" id="14212477"/>
    <dbReference type="KEGG" id="clg:Calag_1217"/>
    <dbReference type="eggNOG" id="arCOG01527">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_5_2_2"/>
    <dbReference type="OMA" id="TYPRVDT"/>
    <dbReference type="OrthoDB" id="14543at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005739">
        <property type="entry name" value="TopoI_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01057">
        <property type="entry name" value="topA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TOP1Bc" evidence="14">
        <location>
            <begin position="141"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="TOP1Ac" evidence="15">
        <location>
            <begin position="281"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ70936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="689" mass="79258" checksum="05864773B804699C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAM8</accession>
    <name>L0AAM8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232055.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70157">
        <property type="protein sequence ID" value="AFZ70157"/>
        <property type="gene ID" value="Calag_0383"/>
    </dbReference>
    <dbReference type="GeneID" id="14211643"/>
    <dbReference type="KEGG" id="clg:Calag_0383"/>
    <dbReference type="HOGENOM" id="CLU_1369466_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="199" mass="23056" checksum="AF1972A1BF0C1168" modified="2013-03-06" version="1">MKKYCIDMLQYLYFANALVNEKSEEWDYIKKKLNNTINVFEKYCNNDALNDHEILEKKSLDFLESVKNDNILNANNNLTDIENLIRNQSKKYVINETFKLFRLFISLTLIITSLIILLSSAINIYQWLLNLFLLGISIGLAALVSYSMIQLPLFFVSLLETINIYLSDNLPLLFSQILITIISLLGIFLNRKINSSKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAT2</accession>
    <name>L0AAT2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="8">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">aIF2-gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">eIF-2-gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eif2g</name>
        <name evidence="10" type="ordered locus">Calag_0466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimer composed of an alpha, a beta and a gamma chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="8"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232130.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0466"/>
    <dbReference type="EnsemblBacteria" id="AFZ70232">
        <property type="protein sequence ID" value="AFZ70232"/>
        <property type="gene ID" value="Calag_0466"/>
    </dbReference>
    <dbReference type="GeneID" id="14211726"/>
    <dbReference type="KEGG" id="clg:Calag_0466"/>
    <dbReference type="eggNOG" id="arCOG01563">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027154_0_1_2"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="OrthoDB" id="25592at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00119">
        <property type="entry name" value="eIF_2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022424">
        <property type="entry name" value="TIF2_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03680">
        <property type="entry name" value="eif2g_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="22"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="413" mass="45412" checksum="2A1AA5F59AE2615A" modified="2013-03-06" version="1">MSENKLEKIQPEVNIGVIGHVDHGKTTLVQALTGTWTMRHSEEIKRGMTIKLGYADGEVWECEGCEFPENYTPEPVCECSPNLKPKLIRRISYVDAPGHEILMATMLSGAALIDGAILVIAANEAAPQPQTLEHFLALDILGIRNLVIVQNKIDVVSTERAKESYNEIRKFISNTWAEKAPIIPVSSLKRVNIDALLAAIEKYIPTPKKDYNKDPLMFVVRSFDVNKPGTKPEDLVGGVLGGSIIQGKFKIGDEIEISPGTQISENKYEPISTEITSLRFGKYEVEEAKPGGLVAIGTKLDPSLTKSDNLVGNIIGKPGSIPPAINELEFEYHLFKNVVGSKEEIKVEPLMKNEILMLAVGTSLTIGTINSISKEAVSVKLKRPVVAWKGLRVAMSRRIAGRWRLIGWGLINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAT9</accession>
    <name>L0AAT9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232930.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1322"/>
    <dbReference type="EnsemblBacteria" id="AFZ71033">
        <property type="protein sequence ID" value="AFZ71033"/>
        <property type="gene ID" value="Calag_1322"/>
    </dbReference>
    <dbReference type="GeneID" id="14212582"/>
    <dbReference type="KEGG" id="clg:Calag_1322"/>
    <dbReference type="eggNOG" id="arCOG00446">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_2_1_2"/>
    <dbReference type="OMA" id="YYVYDAE"/>
    <dbReference type="OrthoDB" id="74513at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="1">
        <location>
            <begin position="22"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="282" mass="31072" checksum="6C3BD9D64BA249E4" modified="2013-03-06" version="1">MRIVVGMKWVPGTTSVRIDPKTGTLIREGVPSIVNPHDMPAVELALQLKDAYGGEVIALTMSPPPAIRGLEYLIGMGVDRAILVSDRVYAGADTLATSYVLAKAIEKIDKEIGKVDLAIFGQETIDSSTAHIGAQTASWLDWPYIYYAHSVKLIDNNKVLVERVLENAIEDWEVEMPAVIGTHMKALKPRPVRLINKIRYKVEKPIVTWTNNEMKLDPRCTGLKGSPTIVAKTVDVPEVPRKKIVYKPKDGEDAAKWLIKTLLEDEKASKAIIKALKEGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAW0</accession>
    <name>L0AAW0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="5">HMG-CoA reductase</shortName>
            <ecNumber evidence="5">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232160.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0496"/>
    <dbReference type="EnsemblBacteria" id="AFZ70262">
        <property type="protein sequence ID" value="AFZ70262"/>
        <property type="gene ID" value="Calag_0496"/>
    </dbReference>
    <dbReference type="GeneID" id="14211756"/>
    <dbReference type="KEGG" id="clg:Calag_0496"/>
    <dbReference type="eggNOG" id="arCOG04260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001734_2_2_2"/>
    <dbReference type="OMA" id="DDKMTRA"/>
    <dbReference type="OrthoDB" id="26445at2157"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="PTHR10572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="SSF55035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="SSF56542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="411" mass="44611" checksum="774E284D0262D508" modified="2013-03-06" version="1">MSSNIDEILDKLEKGELSISRLDQFLKSSNLATLVRRHYLEKKYNIKLTAIASTLLDFEDLVGHNIENPIGAIQIPVGVVGPLKINGDYAKGEFFVPMATTEGALVAGVNRGVKTLTLSGGVKTKILYDGMARAPLIWTPSVEEAHRLSIWLRNNIDKFKELTKQVTSHGELKDMQIFIVGNMIWPRFVFNTADAMGMNIATIASDRICKYIDDTYEGTHKCISVSGNLCVDKKPSYLDKILGRGKYVIAEAIIKKEILKDVMKLSSYEIDYINKSKNLLGNAVSGSLSYNAQFANIIAAIFLATGQDLAQVVESSLGYVWTETRGEDLYISVTLTSLEVGTVGGGTWLPTQKESLQLLGISGGGNPPGTNSLKLAEIIASTALAGELNLLAAQAAGELASAHEKLGRVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAW7</accession>
    <name>L0AAW7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1349"/>
    <dbReference type="EnsemblBacteria" id="AFZ71058">
        <property type="protein sequence ID" value="AFZ71058"/>
        <property type="gene ID" value="Calag_1349"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1349"/>
    <dbReference type="HOGENOM" id="CLU_2613411_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="78" mass="8988" checksum="19F3EF0531FC2B58" modified="2013-03-06" version="1" precursor="true">MMKSSTKEILLLFGFLLLIISMAINIFGLVNTPSVPTKTNPYDNRFDGIFLGMILINLSIMFGFYYKYEELTHEELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAX8</accession>
    <name>L0AAX8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232180.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70282">
        <property type="protein sequence ID" value="AFZ70282"/>
        <property type="gene ID" value="Calag_0518"/>
    </dbReference>
    <dbReference type="GeneID" id="14211778"/>
    <dbReference type="KEGG" id="clg:Calag_0518"/>
    <dbReference type="HOGENOM" id="CLU_1264524_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="218" mass="24610" checksum="2751CC89DC8C4FD3" modified="2013-03-06" version="1">MSNLEVNRNIKLDELMSNIALITDKVVQIVLDLSNSLLIPTMNMFKTIANTLQSQDFISQNPALQENIKNLVKTQENLLNSLIGFSNYVSNVLSNLINNFMASFDQNSIITYFNKFINYVKEIISRVLGILKQIFNIQFLDALLKFVETFMNNLSSNINKISNSGGSISDMLKLMLDQDFIAFINIISPIAKALGQSMRSINIEKQENNQKVSDNSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB28</accession>
    <name>L0AB28_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein containing C-terminal region/beta chain of methionyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232148.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0484"/>
    <dbReference type="EnsemblBacteria" id="AFZ70250">
        <property type="protein sequence ID" value="AFZ70250"/>
        <property type="gene ID" value="Calag_0484"/>
    </dbReference>
    <dbReference type="GeneID" id="14211744"/>
    <dbReference type="KEGG" id="clg:Calag_0484"/>
    <dbReference type="eggNOG" id="arCOG01136">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065946_3_1_2"/>
    <dbReference type="OMA" id="CDKPVLL"/>
    <dbReference type="OrthoDB" id="109426at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="3">
        <location>
            <begin position="12"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="114" mass="12697" checksum="DE22ACB166BD5826" modified="2013-03-06" version="1">MRILEEKIDYSEFSKIDLRVGKVISAELVPNSRKLIKLIVDLGTEQRQILAGLQKWYKPEDFVGKFVVVVANLKSKIMGGLESQGMILAAPCGDDKKPVWLTPQEPVEPGSKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB33</accession>
    <name>L0AB33_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA primase large subunit PriL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">priL</name>
        <name evidence="8" type="ordered locus">Calag_0489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232153.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0489"/>
    <dbReference type="EnsemblBacteria" id="AFZ70255">
        <property type="protein sequence ID" value="AFZ70255"/>
        <property type="gene ID" value="Calag_0489"/>
    </dbReference>
    <dbReference type="GeneID" id="14211749"/>
    <dbReference type="KEGG" id="clg:Calag_0489"/>
    <dbReference type="eggNOG" id="arCOG03013">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052778_1_0_2"/>
    <dbReference type="OMA" id="KYMPYSC"/>
    <dbReference type="OrthoDB" id="29893at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06560">
        <property type="entry name" value="PriL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00701">
        <property type="entry name" value="DNA_primase_lrg_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023642">
        <property type="entry name" value="DNA_primase_lsu_PriL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0639">Primosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="336" mass="38562" checksum="F9A1FB0C492137C8" modified="2013-03-06" version="1">MLTYSKYPFIISLEEYSKMNYGYRIDINSLLENEKIVKISKKRLGEAITKKVSPLKNGDTTDEEVYSFYVSLAAIKASNSVIALDLFAKAEANRASYFIDYEDEENLIALSNAMGLKIEKELIKIPWIINTNGKITYRMLPYYVKMEDYLKIAVNAQENAFRLVNSFLLNGKVYLDIKILKRLLEVGIIVKIKNISKDLEINDLVLDFSNEIFRYLKLAENKIPTSKIEYKAFPPCMTSFRELLDKGKIDEERLYQYIAFLISIGIDEEELSDILANGLGISPNLSKRIAKAFLSIEDLSPYRCDVMKKKNLCPKDCGGKHPVLVYKKNLQDMSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB40</accession>
    <name>L0AB40_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase involved in DNA repair</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232260.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0605"/>
    <dbReference type="EnsemblBacteria" id="AFZ70362">
        <property type="protein sequence ID" value="AFZ70362"/>
        <property type="gene ID" value="Calag_0605"/>
    </dbReference>
    <dbReference type="GeneID" id="14211865"/>
    <dbReference type="KEGG" id="clg:Calag_0605"/>
    <dbReference type="eggNOG" id="arCOG00368">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004785_0_2_2"/>
    <dbReference type="OMA" id="FELPYSH"/>
    <dbReference type="OrthoDB" id="1771at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="6">
        <location>
            <begin position="424"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="220"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="488"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="918" mass="107630" checksum="81955B021DB69051" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB46</accession>
    <name>L0AB46_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0894"/>
    <dbReference type="EnsemblBacteria" id="AFZ70634">
        <property type="protein sequence ID" value="AFZ70634"/>
        <property type="gene ID" value="Calag_0894"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0894"/>
    <dbReference type="eggNOG" id="arCOG01434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_0_2"/>
    <dbReference type="OMA" id="DDVNRFC"/>
    <dbReference type="OrthoDB" id="16594at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="2">
        <location>
            <begin position="46"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="336" mass="37424" checksum="651FE628A1AA70D2" modified="2013-03-06" version="1">MFKMWKLFCKKCGFEGEEDKYYPFCPVCKSSLYIKGEKPKFNSILGEGNTPSVKENINGYEVYFKMEYLNPTGSFKDRGVSYSLQLASSLKYKCAVEDSSGNTGISTAAYSSRLGLKSKIVIPKTAPQGKKALLKSLNAEIIESNTRDEASLIAEDLSRSCFYVSHARNPFFIEGMKSIAKEIEKIKPRGVIIPSSSFSLFLGTYYGLKEIGINAKMFAVQGIETASLKEFIDPIYESKGKESKLADGLALKKSPRGEDAIKALKESNGGLIVLDDDEIKLGLKKLWQMGYMVEPTSATSYIALIRLIELNYDVNDYVLMLTGNGLKFYDLIEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB54</accession>
    <name>L0AB54_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233020.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1416"/>
    <dbReference type="EnsemblBacteria" id="AFZ71123">
        <property type="protein sequence ID" value="AFZ71123"/>
        <property type="gene ID" value="Calag_1416"/>
    </dbReference>
    <dbReference type="GeneID" id="14212676"/>
    <dbReference type="KEGG" id="clg:Calag_1416"/>
    <dbReference type="eggNOG" id="arCOG05341">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062369_0_0_2"/>
    <dbReference type="OMA" id="GVWMSEV"/>
    <dbReference type="OrthoDB" id="95764at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="6"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="373" mass="40991" checksum="7604C5A99F437339" modified="2013-03-06" version="1" precursor="true">MNKINNMIGILLPFTLSAFSVFSISMVLLQITNYFKVPLYIISFTFPLDFIGGAVGGVILGKFADKIGRKMTTIISILIFSISLILASFSNSLIELFICWFFIGFGVNAENGIAYALIVETLGSYTGSFGGLVQGLYYIGFGLDVLTYRFIAYWRTLFLIVGIISLAIGLPSSIIIKETLKRTQTKPVGIRNLFNIEYRYKTILLSLIVIGAFLLSVPLLSIVPSFMEKINMTNYIGVLSIVGFLSYWFSGFLSDKIGRAKNTLIFSSLGLLSAILLIFFGISSLLIVVFLALLYISSGLFSYDGIWVSENYPIELRATASNFVFMFGRLIGGFAPEITSLIGSLNLSYGLGIVSAISSALILISSIIFTRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB81</accession>
    <name>L0AB81_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">dTDP-glucose 4,6-dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232571.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0943"/>
    <dbReference type="EnsemblBacteria" id="AFZ70674">
        <property type="protein sequence ID" value="AFZ70674"/>
        <property type="gene ID" value="Calag_0943"/>
    </dbReference>
    <dbReference type="GeneID" id="14212203"/>
    <dbReference type="KEGG" id="clg:Calag_0943"/>
    <dbReference type="eggNOG" id="arCOG01371">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_2"/>
    <dbReference type="OMA" id="KLIPLMC"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="2">
        <location>
            <begin position="4"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="336" mass="39154" checksum="DD247522D8B1B560" modified="2013-03-06" version="1">MRYLITGGLGFIGSNFVRYLLENYKEENNLITIVDYMGIGSNINNLKGLEGKYELINADIANKNIMKKLIENIDIIINFAAETHVDRSISNPEPFLHSNLIGVFNILEIIRESKRKNEIKLIHISTDEVYGDLFNSEADENFPLKPSSPYSAAKASADLFILSYNRTYDINAIILRPSNNYGYYQFPEKLIPKTIIKALNDQKIPLYGDGNQERQWTFVIDTCNAIYEISKKSNKYGEIYNVSSNDVVKNIEVVKKILKLLNKDEGLIEFVEDRPGHDKRYKTISEKIKKSINWYPKYNFEKGIELTVRWYVSNEWWWKPLINEKVLNKTPWKVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB92</accession>
    <name>L0AB92_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0560"/>
    <dbReference type="EnsemblBacteria" id="AFZ70320">
        <property type="protein sequence ID" value="AFZ70320"/>
        <property type="gene ID" value="Calag_0560"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0560"/>
    <dbReference type="eggNOG" id="arCOG01630">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_2"/>
    <dbReference type="OMA" id="ATDKAPQ"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="126" mass="14112" checksum="E1DBB0A6DABF8CDB" modified="2013-03-06" version="1">MREAVFTDKAPKPIGPYSQAISYNGLLFISGQVPLDPKTGKIVSDNFEEQVRRVLENIKAILEASNLTFENLIKVTVFMKDSSKFSIFNNIYSTYFKGQYPSRSVIFVNDLPANAQIEVEAIAAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB97</accession>
    <name>L0AB97_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0566"/>
    <dbReference type="EnsemblBacteria" id="AFZ70325">
        <property type="protein sequence ID" value="AFZ70325"/>
        <property type="gene ID" value="Calag_0566"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0566"/>
    <dbReference type="eggNOG" id="arCOG00436">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018678_0_0_2"/>
    <dbReference type="OMA" id="TRFTEPD"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045427">
        <property type="entry name" value="MoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041538">
        <property type="entry name" value="RavA-like_AAA_lid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17868">
        <property type="entry name" value="AAA_lid_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20030">
        <property type="entry name" value="bpMoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="42"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="384" mass="44102" checksum="D4C042EBACB03926" modified="2013-03-06" version="1">MCALSDEPSNLLDLANKFLASLEEPFVGRHEEALVITLSLITGEHVVLIGEPGTAKSAMARRSADLLEAKYFKYLLTKFTEPSELFGPLDIAGLRRGIYKRITKNKLPEAEIAFLDEIFNANSAVLNSILSIMQERILYDGYNEIKVPLWTLMGASNKIPDEPELEALYDRFLFRHNVKPVDEEHWDGLLDASWNIEKGVYYQANKIMEMNNIKSLNSMIFKVDISNIKNKLLKMFIILSEKGLQLSDRRKGKILKAIAAHALLEKRFQATESDLIVLKYTVPKNFEDFEKIETILMEELKTKDRVIRELEEISSNIKNSKRVIQQMQSFDPRLLEIYKGLKTAKSKVQNLVQDVEDEEVRKKAEELNEMIDSLSQDIMIKLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-12-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB98</accession>
    <name>L0AB98_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0971"/>
    <dbReference type="EnsemblBacteria" id="AFZ70694">
        <property type="protein sequence ID" value="AFZ70694"/>
        <property type="gene ID" value="Calag_0971"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0971"/>
    <dbReference type="eggNOG" id="arCOG00349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_9_1_2"/>
    <dbReference type="OMA" id="TIRVWIE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="91" mass="10126" checksum="9B1B00CB22E4FC07" modified="2013-03-06" version="1">MIKMTIRVWIEPRENCIADMVCVSLAGDVFEMSDVDGKSNVIAKWRKDPNNINEGFVPDDLKDAVDAAVQSCPTQIIHAEPSQEIIQQQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABA0</accession>
    <name>L0ABA0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secondary thiamine-phosphate synthase enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233065.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1465"/>
    <dbReference type="EnsemblBacteria" id="AFZ71168">
        <property type="protein sequence ID" value="AFZ71168"/>
        <property type="gene ID" value="Calag_1465"/>
    </dbReference>
    <dbReference type="GeneID" id="14212725"/>
    <dbReference type="KEGG" id="clg:Calag_1465"/>
    <dbReference type="eggNOG" id="arCOG04214">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096980_1_2_2"/>
    <dbReference type="OMA" id="VRHTSCS"/>
    <dbReference type="OrthoDB" id="85388at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="136" mass="15744" checksum="BF050559A0D16AEC" modified="2013-03-06" version="1">MKFEVSNIEINTNQRIEILDITNKVENIIKQKNYEKGILNLYVLHTTAAITLNEYEPNLEEDLKRIISEIFRPDGDWKHNLIDDNAHAHLASSFIGNSRSLLIESGKIVLGTWQRILFIELDGPRKRMVKIVFIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABB6</accession>
    <name>L0ABB6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232330.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0687"/>
    <dbReference type="EnsemblBacteria" id="AFZ70432">
        <property type="protein sequence ID" value="AFZ70432"/>
        <property type="gene ID" value="Calag_0687"/>
    </dbReference>
    <dbReference type="GeneID" id="14211947"/>
    <dbReference type="KEGG" id="clg:Calag_0687"/>
    <dbReference type="eggNOG" id="arCOG13712">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1063962_0_0_2"/>
    <dbReference type="OMA" id="VHYDLCE"/>
    <dbReference type="OrthoDB" id="137495at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="261" mass="30494" checksum="58258B2C8B748D25" modified="2013-03-06" version="1">MLSLRKEQNDVEWASKLIDECIMNYKNGNGMNGYLPSCLSNLKEQLNKGTKKENLINYILNFKKIADDLFGKLVSDYNLEYQLPSNVDPKDVAVYVWPSLLSDGNSLNLYSLTLYNWFSFSFKKGDGKSELEPITFLFNKEKDTYKLIMAYARVHYDLCEYNIEKIKGIKVIFARYGHTPYILGENYVRVKCPKVKHSNSRTGRKYWDRMWLAAGNIFTRITGIRKVQFKFKNNIKVYILGCLPKTNNNPFKSPIYPLQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABC9</accession>
    <name>L0ABC9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar pyrophosphorylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0697"/>
    <dbReference type="EnsemblBacteria" id="AFZ70442">
        <property type="protein sequence ID" value="AFZ70442"/>
        <property type="gene ID" value="Calag_0697"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0697"/>
    <dbReference type="eggNOG" id="arCOG00666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_2_2"/>
    <dbReference type="OMA" id="YMPRVET"/>
    <dbReference type="OrthoDB" id="61185at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="411" mass="46941" checksum="289FC3D2710C9B59" modified="2013-03-06" version="1">MPIKKTLIPIGGLGTRLYPLTVDTSKPMVRFLNNFLIDYTLSELAYRGINEVFLGVSGYYNYRDVYDHLGERFKVKIDGEIKSIKLRYQPNEDSIGNAHSVKIMADYYDIYDDVLVFQGDTVASINVNNIYKFHQSNDAFMTIVLKEIVEPEKLRQFGVAKIDENMRIESFVEKPSNPNELPSRLVNTGIYLLSSDFVKFLRSSEFNEILKLGKGDFGKDIIPYIISKNYKVMGYVSNSYWFDVGTLESFMEASYYLLNNLDKERLHVETEYRNVYMQGMSKRSKNDHIEIIEKIATNKIIVSGKNLIGRHVKIGENVKLSSSIIDNYTVVENDMEISNSIVMDRSLLKTGSIIKNSILGRHVKIGENVKIINSHLGNNVIIGDNAELINSSIWPHRSIESKSSIVDRKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABE0</accession>
    <name>L0ABE0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1513"/>
    <dbReference type="EnsemblBacteria" id="AFZ71213">
        <property type="protein sequence ID" value="AFZ71213"/>
        <property type="gene ID" value="Calag_1513"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1513"/>
    <dbReference type="HOGENOM" id="CLU_2839187_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="65" mass="8127" checksum="B1CDDE95AC5409BE" modified="2013-03-06" version="1">MVTNLNKMFLVFYLYYANFKELGDFLSFILIKMIRINYYKQYKILEDIRIYLIFIIIKERLFILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABE7</accession>
    <name>L0ABE7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein, family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232273.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0620"/>
    <dbReference type="EnsemblBacteria" id="AFZ70375">
        <property type="protein sequence ID" value="AFZ70375"/>
        <property type="gene ID" value="Calag_0620"/>
    </dbReference>
    <dbReference type="GeneID" id="14211880"/>
    <dbReference type="KEGG" id="clg:Calag_0620"/>
    <dbReference type="eggNOG" id="arCOG01533">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319962_0_0_2"/>
    <dbReference type="OrthoDB" id="6658at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="347"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="940" mass="105495" checksum="F5BF2157A857675B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABF1</accession>
    <name>L0ABF1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aspartate carbamoyltransferase regulatory chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrI</name>
        <name evidence="10" type="ordered locus">Calag_1027</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in allosteric regulation of aspartate carbamoyltransferase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Contains catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PyrI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1027"/>
    <dbReference type="EnsemblBacteria" id="AFZ70749">
        <property type="protein sequence ID" value="AFZ70749"/>
        <property type="gene ID" value="Calag_1027"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1027"/>
    <dbReference type="eggNOG" id="arCOG04229">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128576_0_0_2"/>
    <dbReference type="OMA" id="CPNRNCI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009347">
        <property type="term" value="C:aspartate carbamoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00002">
        <property type="entry name" value="Asp_carb_tr_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020545">
        <property type="entry name" value="Asp_carbamoyltransf_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002801">
        <property type="entry name" value="Asp_carbamoylTrfase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020542">
        <property type="entry name" value="Asp_carbamoyltrfase_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036792">
        <property type="entry name" value="Asp_carbatrfase_reg_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036793">
        <property type="entry name" value="Asp_carbatrfase_reg_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805">
        <property type="entry name" value="PTHR35805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01948">
        <property type="entry name" value="PyrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02748">
        <property type="entry name" value="PyrI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54893">
        <property type="entry name" value="SSF54893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57825">
        <property type="entry name" value="SSF57825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00240">
        <property type="entry name" value="ATCase_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PyrI" evidence="8">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="PyrI_C" evidence="9">
        <location>
            <begin position="105"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="163" mass="18179" checksum="7A642F923745EBB6" modified="2013-03-06" version="1">MSIKKDDKLLVSKIESGTVIDHINSGRALVVLKILNIKGNEGYRIAIVMNVPSTTMGKKDIVKLEDYYPNSEDLEKISLISPSATINIIKNYEVVKKYKVEIPSKIKGTLKCNNPTCITRKSNEPITSSFTLLSKDKIKLQCDYCGSILTEDDIIKELIGESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABF6</accession>
    <name>L0ABF6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232651.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1032"/>
    <dbReference type="EnsemblBacteria" id="AFZ70754">
        <property type="protein sequence ID" value="AFZ70754"/>
        <property type="gene ID" value="Calag_1032"/>
    </dbReference>
    <dbReference type="GeneID" id="14212292"/>
    <dbReference type="KEGG" id="clg:Calag_1032"/>
    <dbReference type="eggNOG" id="arCOG02050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_5_0_2"/>
    <dbReference type="OMA" id="LCITRAI"/>
    <dbReference type="OrthoDB" id="66636at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="276" mass="28514" checksum="52C47EA83D662609" modified="2013-03-06" version="1">MITIIQYALSIVSGVIVGFSLGLIGGGGSILAVPLLLYFVGLSSMPNAAHIALGTTALAVGLNAFANSYMHLRKRNVAVKTGGIFAGVGVVGSLIGTYLGHITPGSSLLLYFAIAMIVLGFYVGFGRNSAKAGTHEEIPRINEATKKCKKLTSRSLVFVGVFGFLVGLVSGYFGIGGGFLIVPALMFSSSLCISRAIGTSLISVGAFGLTSGLLYLYYGDTIVQISLLYLVGGLLGGYIGTSLAVKAPKSTLQKAYGAIIVLVGIYMIFKVAHLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABH2</accession>
    <name>L0ABH2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small G protein, GTPase SAR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232666.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1047"/>
    <dbReference type="EnsemblBacteria" id="AFZ70769">
        <property type="protein sequence ID" value="AFZ70769"/>
        <property type="gene ID" value="Calag_1047"/>
    </dbReference>
    <dbReference type="GeneID" id="14212307"/>
    <dbReference type="KEGG" id="clg:Calag_1047"/>
    <dbReference type="eggNOG" id="arCOG01225">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_3_0_2"/>
    <dbReference type="OMA" id="CFEYLLQ"/>
    <dbReference type="OrthoDB" id="86220at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="PTHR21231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="PTHR21231:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="258" mass="28735" checksum="E77B3CC41F3FE3BD" modified="2013-03-06" version="1">MYIILLGTAGAGKSTLAGELRSVMEETGGNVAIVNFDPAAEKLPYDPDVDVRNYVNIEDFLDKGLGPNGSLVSAVDSLINYTDKIRNEIDKFKPDFTIIDTPGQLELFSYRVGGPLVLNSLIYNDKAVVIFLMDSIFFDNPANMVSILTLASSVNTRFKKPQINVISKSDLLSEEVVNEIIPRLHEEGYLESLLRDFKELDGYTLSLSLSLARALYEAGYFGHILPVSIFNELSLRNLYGQIQDILTEGEDYKVYDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABI5</accession>
    <name>L0ABI5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232681.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1062"/>
    <dbReference type="EnsemblBacteria" id="AFZ70784">
        <property type="protein sequence ID" value="AFZ70784"/>
        <property type="gene ID" value="Calag_1062"/>
    </dbReference>
    <dbReference type="GeneID" id="14212322"/>
    <dbReference type="KEGG" id="clg:Calag_1062"/>
    <dbReference type="eggNOG" id="arCOG03681">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1998627_0_0_2"/>
    <dbReference type="OMA" id="CAHVREY"/>
    <dbReference type="OrthoDB" id="126614at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="133" mass="16103" checksum="A0AF05ADA858BB88" modified="2013-03-06" version="1">MEKVSEILNSNLEWSDVERFLYYRPYHYHVLIKKTNIGHPKESGYKRSYGEYNGEKYDWRKTLIDGSCAHVREYDTYYIVHRDRVNPDDNLIKHIALDSLKSLPKILPFIIPILLLRYNYKLVKKKRLRRSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABK4</accession>
    <name>L0ABK4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232701.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1082"/>
    <dbReference type="EnsemblBacteria" id="AFZ70804">
        <property type="protein sequence ID" value="AFZ70804"/>
        <property type="gene ID" value="Calag_1082"/>
    </dbReference>
    <dbReference type="GeneID" id="14212342"/>
    <dbReference type="KEGG" id="clg:Calag_1082"/>
    <dbReference type="eggNOG" id="arCOG01572">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097040_1_0_2"/>
    <dbReference type="OMA" id="FGVWGPN"/>
    <dbReference type="OrthoDB" id="121178at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008910">
        <property type="entry name" value="TM_helix"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05552">
        <property type="entry name" value="TM_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="195" mass="22083" checksum="45CC90936FFF47D5" modified="2013-03-06" version="1">MQIIDYIIDAVIFILIIVVFYLIGKFVKFLVKRTLEITGFNDWFKHISMGRITLRAGMTAGDFFGNLIAYFLYATGVILSIDYLSTYVTEIRITSSLLTKGLGYVALFVFIIIIGFILIDVFDSYISSEAKLRGGQELEILIVYIKIVLYITVITLAMREVSLDVTPLMILLQPLAWGLAIAFVALIISRYIRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABM5</accession>
    <name>L0ABM5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232424.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0785"/>
    <dbReference type="EnsemblBacteria" id="AFZ70527">
        <property type="protein sequence ID" value="AFZ70527"/>
        <property type="gene ID" value="Calag_0785"/>
    </dbReference>
    <dbReference type="GeneID" id="14212045"/>
    <dbReference type="KEGG" id="clg:Calag_0785"/>
    <dbReference type="eggNOG" id="arCOG06075">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1763780_0_0_2"/>
    <dbReference type="OMA" id="DIVEMYY"/>
    <dbReference type="OrthoDB" id="121541at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="147" mass="17243" checksum="4E9672FB06429E05" modified="2013-03-06" version="1">MDSNSIPNSNGFYFFDPKSFKWVIIACDETNLNYFHDGVNIIYFSNNLCPACKIFNLIWYPFVNNFSKTKNTYFYVFVCEWFTEFCNSDCSRKGFIYFKIKASPTVVIIIKHKDKIVKKVIEGNVGIDILNEIVNESISLYKKFLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABT1</accession>
    <name>L0ABT1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein implicated in regulation of membrane protease activity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232402.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0761"/>
    <dbReference type="EnsemblBacteria" id="AFZ70505">
        <property type="protein sequence ID" value="AFZ70505"/>
        <property type="gene ID" value="Calag_0761"/>
    </dbReference>
    <dbReference type="GeneID" id="14212021"/>
    <dbReference type="KEGG" id="clg:Calag_0761"/>
    <dbReference type="eggNOG" id="arCOG01912">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1880960_0_0_2"/>
    <dbReference type="OMA" id="RVDNELW"/>
    <dbReference type="OrthoDB" id="38523at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="53"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="135" mass="15047" checksum="7CD01E76D6FDB3CF" modified="2013-03-06" version="1">MNSNENNVGFFSKIRWGVGSISIIILLIILSILFAVVYKYNHNGFYLFLSILFAVVAIIIIIVKSSEIIMPINPTVTTLIGKTGVVIKRILPNNPGVIKISDQLWSAKSDEEIDENSEVEVISVEGIYLKVKRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABU1</accession>
    <name>L0ABU1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5622 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232796.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1178"/>
    <dbReference type="EnsemblBacteria" id="AFZ70899">
        <property type="protein sequence ID" value="AFZ70899"/>
        <property type="gene ID" value="Calag_1178"/>
    </dbReference>
    <dbReference type="GeneID" id="14212438"/>
    <dbReference type="KEGG" id="clg:Calag_1178"/>
    <dbReference type="eggNOG" id="arCOG04104">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188105_0_0_2"/>
    <dbReference type="OMA" id="FAYIYMG"/>
    <dbReference type="OrthoDB" id="142950at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041043">
        <property type="entry name" value="DUF5622"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18533">
        <property type="entry name" value="DUF5622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5622" evidence="1">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="68" mass="8098" checksum="6E1BA5D5F1EF6629" modified="2013-03-06" version="1">MGSKNTKFAYIYMGRKKGYYKVRLFNSKPEEDPDRIIVIGKFKKPELGYRIIKKEELLEVVREKVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABW0</accession>
    <name>L0ABW0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Formate dehydrogenase</fullName>
            <ecNumber evidence="5">1.17.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Calag_1200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232816.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1200"/>
    <dbReference type="EnsemblBacteria" id="AFZ70919">
        <property type="protein sequence ID" value="AFZ70919"/>
        <property type="gene ID" value="Calag_1200"/>
    </dbReference>
    <dbReference type="GeneID" id="14212460"/>
    <dbReference type="KEGG" id="clg:Calag_1200"/>
    <dbReference type="eggNOG" id="arCOG00937">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01492">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_4_0_2"/>
    <dbReference type="OMA" id="DGPPCCY"/>
    <dbReference type="OrthoDB" id="1029at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009326">
        <property type="term" value="C:formate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015942">
        <property type="term" value="P:formate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02753">
        <property type="entry name" value="MopB_Formate-Dh-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041924">
        <property type="entry name" value="Formate_Dh-H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006478">
        <property type="entry name" value="Formate_DH_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01591">
        <property type="entry name" value="Fdh-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00932">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="14">
        <location>
            <begin position="208"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ70919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="886" mass="99973" checksum="7777FBA01F40676F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABZ5</accession>
    <name>L0ABZ5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RecB-family nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232851.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1237"/>
    <dbReference type="EnsemblBacteria" id="AFZ70954">
        <property type="protein sequence ID" value="AFZ70954"/>
        <property type="gene ID" value="Calag_1237"/>
    </dbReference>
    <dbReference type="GeneID" id="14212497"/>
    <dbReference type="KEGG" id="clg:Calag_1237"/>
    <dbReference type="eggNOG" id="arCOG01019">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140136_0_0_2"/>
    <dbReference type="OMA" id="LFKLAFK"/>
    <dbReference type="OrthoDB" id="90556at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018665">
        <property type="entry name" value="DUF2122_RecB-nuclease-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09895">
        <property type="entry name" value="DUF2122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="152" mass="16511" checksum="AF5302A6C2B457FB" modified="2013-03-06" version="1">MDAKIIPVIHNVSSVQKLIDMAKLSFGFGYKMIIISKAYGSAAQNGIAEVFKIALKEGKGVVVLPDLKDALELYNPKKVILIDKDNAKEEIDIVNPPVNNETLIVFNGSDSSFSPNELTLGEPYYIKGIKSRIGSVAEAALILYSFSQGHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABZ6</accession>
    <name>L0ABZ6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232467.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0829"/>
    <dbReference type="EnsemblBacteria" id="AFZ70570">
        <property type="protein sequence ID" value="AFZ70570"/>
        <property type="gene ID" value="Calag_0829"/>
    </dbReference>
    <dbReference type="GeneID" id="14212089"/>
    <dbReference type="KEGG" id="clg:Calag_0829"/>
    <dbReference type="eggNOG" id="arCOG04537">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_0_1_2"/>
    <dbReference type="OMA" id="CREGTDW"/>
    <dbReference type="OrthoDB" id="29942at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="6">
        <location>
            <begin position="394"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="475" mass="53227" checksum="C948304DEF51BA15" modified="2013-03-06" version="1">MVRINLPKKEINTFYAFADKELPEEYCRGLSCFVNRNENMDYWNKAKEQNPRTYCLGKCYSSPSSTNEDPKPLIDIISKEPVLGNYLKNGIYSLKDYIKMGGMSSYEYAITSLSQKDVINEVKVSYLRGRGGAGFPTGLKWESAYNQKEEERYLIINGDEGDPGAFSDRFLMEYSPYLVIEGALIAAYAINAKEIYFYIRREYPKSISRIKNAIIEIKNYFNGKKIPKINVEIGKGSYVVGEETALINAIMGRRPEPNSRPPYPTERGLFGKPTVVNNVETISNIPYIIKNGGKKYYDLGFSKSRGTKLISLNSLFKKPGLYEVEFGITLDEIIKKAGGLKRGNLKGLIIGAPLSGIITPEELNTKLGYEELKEIGSSLGHGNIIAFNDETKIADLLYEILEFSSYESCGKCTPCRLGTKKLKDLISKGYFEKNELKEVNDVLLALKNTSLCGLGIGTGDVVFSILNKYGNEVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC08</accession>
    <name>L0AC08_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70580">
        <property type="protein sequence ID" value="AFZ70580"/>
        <property type="gene ID" value="Calag_0839"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0839"/>
    <dbReference type="eggNOG" id="arCOG06025">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1149770_0_0_2"/>
    <dbReference type="OMA" id="IPYLGIW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="241" mass="27451" checksum="3B1AADD6AE6646E0" modified="2013-03-06" version="1">MAHGLMSSMILSLALAIGLARKISIFVPLVLINGIIDIYAFNYLRLKVTKLNLKDLILLVILFIPYIIMLKLNNFYLIMPISLLILYLIFSFKKKFVLSNIIGSTFIASLSLIWLLMISNINVEQFLIILSWIIFTLTLSVIVEYKLPFRKIDKVSTIGYPLIIISLGIAITYLLGYYDLILLYTFPISALILSGEKLRNVKEIKKIGKIGMYSSLSFILIGIMLYNLFLTPINLNIIFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC29</accession>
    <name>L0AC29_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232487.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0849"/>
    <dbReference type="EnsemblBacteria" id="AFZ70590">
        <property type="protein sequence ID" value="AFZ70590"/>
        <property type="gene ID" value="Calag_0849"/>
    </dbReference>
    <dbReference type="GeneID" id="14212109"/>
    <dbReference type="KEGG" id="clg:Calag_0849"/>
    <dbReference type="eggNOG" id="arCOG02007">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014051_4_1_2"/>
    <dbReference type="OMA" id="DVGAVWC"/>
    <dbReference type="OrthoDB" id="12642at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="2">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="653" mass="75821" checksum="A13A787BE547B58F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC34</accession>
    <name>L0AC34_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232891.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1280"/>
    <dbReference type="EnsemblBacteria" id="AFZ70994">
        <property type="protein sequence ID" value="AFZ70994"/>
        <property type="gene ID" value="Calag_1280"/>
    </dbReference>
    <dbReference type="GeneID" id="14212540"/>
    <dbReference type="KEGG" id="clg:Calag_1280"/>
    <dbReference type="eggNOG" id="arCOG04268">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1109465_0_0_2"/>
    <dbReference type="OMA" id="KQWGSTY"/>
    <dbReference type="OrthoDB" id="79884at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="241" mass="27807" checksum="80DAF23B16C4231A" modified="2013-03-06" version="1">MSDPNDIDKLINRIKNNEIGGPRSKLVDAILILLASRPMRSSEISQYLNKETKYISSYLSYWKERGFVEYDMGLWYLTPKGEDFARELISNASNEKFNEFVALAQKVAGELVKQTIKDKDNMGERGKTKGSLSFIANRTNSADNKRQNRVSQVACVLQQLKDSIDEEEMEITSFLLTHYAKYGVTYVYLDQMMEKLNADYGWLLKRLRNLQSKGILYIYTDPRLGIRVGLTRNLKDMLKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC58</accession>
    <name>L0AC58_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Acidic ribosomal protein P0 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl10</name>
        <name evidence="2" type="synonym">rplP0</name>
        <name evidence="5" type="ordered locus">Calag_1307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232916.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1307"/>
    <dbReference type="EnsemblBacteria" id="AFZ71019">
        <property type="protein sequence ID" value="AFZ71019"/>
        <property type="gene ID" value="Calag_1307"/>
    </dbReference>
    <dbReference type="GeneID" id="14212567"/>
    <dbReference type="KEGG" id="clg:Calag_1307"/>
    <dbReference type="eggNOG" id="arCOG04288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053173_0_0_2"/>
    <dbReference type="OMA" id="MAHVAEW"/>
    <dbReference type="OrthoDB" id="73593at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00280">
        <property type="entry name" value="Ribosomal_L10_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022909">
        <property type="entry name" value="50S_L10_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="RL10_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="RL10P_insert"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RL10P_insert" evidence="4">
        <location>
            <begin position="115"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="338" mass="37558" checksum="A1AD99D9D8DDE0FE" modified="2013-03-06" version="1">MSVIVQKKGRKEPPENKRKELEMLIELMKSKKYVIFADLESMPTKQLQLIKKELRNEAIFRVSKKRLVLMALERLGLNKEKIEPYLKKGVLVILTDTNPFKVSMMLDKLKMPAPAKAGAQSPKEIVVPEGDTNIRPGPMVSVFGKLKIPYEVRKGTIYIKSDTVVAKKGDVISQELASLLQQLGIQPFEIGLNLIIAWDKSTIIPSDVLHVDLEAIKSDVITAEKEAIGLAVEAAYLDVPDAVNSILLTAEREANALIQEAGLALDKETAELSVKKAYVEEEAISSSLGDKAKELGIEITKPVVQQQEKKKEEKKEEKKEEENKEVDVSEGLSGLFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC98</accession>
    <name>L0AC98_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232654.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1035"/>
    <dbReference type="EnsemblBacteria" id="AFZ70757">
        <property type="protein sequence ID" value="AFZ70757"/>
        <property type="gene ID" value="Calag_1035"/>
    </dbReference>
    <dbReference type="GeneID" id="14212295"/>
    <dbReference type="KEGG" id="clg:Calag_1035"/>
    <dbReference type="eggNOG" id="arCOG04319">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1048069_0_0_2"/>
    <dbReference type="OMA" id="IFRIYYK"/>
    <dbReference type="OrthoDB" id="122482at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009198">
        <property type="entry name" value="UCP014484_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09973">
        <property type="entry name" value="DUF2208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="255" mass="29985" checksum="C6483F987E186D57" modified="2013-03-06" version="1">MSFYIEQRWKSTLLNQVYIIIYSILAAIIGVNYLLFILVIVFVIISMFLQSYLSGSPLGKNIKPQEVLQGKRLYHEPETRSIQMKDKQVMVDFQEQSRFTMYTTIGMFIGLIYFFVLFRYVPDLANFLKLYITDYRIDLFLAFLIYFEGYFAITMLNTMWAVSRIKKLPMVNVPSQYTITDKGIVIKGLVTTKGIAFPLPNETNVNLNEERRFVEIIKEGKRTITKLRFYSKNPKRLYEIIKKYGKIDQQDGQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACA7</accession>
    <name>L0ACA7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232567.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0939"/>
    <dbReference type="EnsemblBacteria" id="AFZ70670">
        <property type="protein sequence ID" value="AFZ70670"/>
        <property type="gene ID" value="Calag_0939"/>
    </dbReference>
    <dbReference type="GeneID" id="14212199"/>
    <dbReference type="KEGG" id="clg:Calag_0939"/>
    <dbReference type="eggNOG" id="arCOG11499">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_777558_0_0_2"/>
    <dbReference type="OMA" id="EISARTY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="356" mass="39446" checksum="7CBF1F6E17796897" modified="2013-03-06" version="1" precursor="true">MIRYQFNKATYLFLILVFTSIVTSSLIISGEIMGVYNLYNIIQSLGGKNSLIITGYSVSPYTSLINKNDLLNKLRNTSGIENITFLVISLGYVNGKDVAFIGNNNVSDAYCAYPSYYVKNELNLKINQTILVYPALSNFPIILKVCNFSNLYPWAISVNINTAYLIHGGGINYGLASLAIIDFKNSSYKLSAMKSLSLTPVQKSLINTALILVQNNQGEKMLFNEASQAYFNKLGIPKIAFLSLAIASALIISIASYTIGLIFNLIDKDRIEILNNYGISKMKIMFNSIAISLLLLLISFIISLFIFNKIKYLLSTNLLGLPLIPSINIYIMLSTLISIMVISTISIIINNGDYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACH4</accession>
    <name>L0ACH4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myo-inositol-1-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1033"/>
    <dbReference type="EnsemblBacteria" id="AFZ70755">
        <property type="protein sequence ID" value="AFZ70755"/>
        <property type="gene ID" value="Calag_1033"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1033"/>
    <dbReference type="eggNOG" id="arCOG04213">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050011_0_0_2"/>
    <dbReference type="OMA" id="YEVNAFY"/>
    <dbReference type="OrthoDB" id="46491at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="1">
        <location>
            <begin position="214"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="383" mass="42055" checksum="453AD00A8CE4F501" modified="2013-03-06" version="1">MPIRTVLLGAGPGAAYFSAGIERLKMGEIESYGIPFGNLFRSYRPEDIQIVGVFDVDNKKIGLDMYSLTTKLLNDENVPKTLKDIEILRGLHCKSLQGLPIDAMGLDDIIGDSNIAMNEFISLLDKLKPDVIVNIITTEKQIQVNNESEFIKLAKSCNGTASLAYAYAAAEYSRLHNRVSFINLTPPLLANSPGVVSYYEKVGGLIFGDDAATGATPLTADLLEHMAERNRKVNSVAQFNIGGNMDFLSLTEPERNKSKENTKGSIVNDILGYDAPHYIKPTGYLEPLGDRKFIAMHIEYISFGGFTDEIVVTGRINDKANLGGVMASVIPITKAYIDRGYKGTVSSINRFFMKKPGPLGTKNVSRIIAYNELMKELKALDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACH6</accession>
    <name>L0ACH6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1125"/>
    <dbReference type="EnsemblBacteria" id="AFZ70847">
        <property type="protein sequence ID" value="AFZ70847"/>
        <property type="gene ID" value="Calag_1125"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1125"/>
    <dbReference type="eggNOG" id="arCOG00071">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050152_0_0_2"/>
    <dbReference type="OMA" id="PMEVVNC"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="323" mass="37326" checksum="29E2B4C0DA29AA37" modified="2013-03-06" version="1">MCIEYAEKLSKIIYENSRKNNCDCILFSGGIDTTFILMSLINEKPKTISVVFNESKDKEYIDYVKNKLNIENYEIIIKNEQEIGDCLNNVLYSLKVIDPIEIISGVSVCLGLKKAKELKCNCIITGDGGDELYFGYDFLLNRNESYLNNWLKNVLNNAFFNSIPISNYMGIKAILPLYSNESKELSLSIPTKCKINEINGKIYGKYFMRLWLMRKGLEFVALRNKTPITIGTGSEILLQSWKNKVKKEEIQEYKNKYRINFPSLSHFYLFKKGLELGIFNDELENKSNKNPCPICGHEMKGNHCKFCGTYIDEKGQISYYKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACH9</accession>
    <name>L0ACH9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_1407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233011.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1407"/>
    <dbReference type="EnsemblBacteria" id="AFZ71114">
        <property type="protein sequence ID" value="AFZ71114"/>
        <property type="gene ID" value="Calag_1407"/>
    </dbReference>
    <dbReference type="GeneID" id="14212667"/>
    <dbReference type="KEGG" id="clg:Calag_1407"/>
    <dbReference type="eggNOG" id="arCOG00899">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_843589_0_0_2"/>
    <dbReference type="OMA" id="VIYEVYY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ71114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="292" mass="32992" checksum="7B2B4C7853011E12" modified="2013-03-06" version="1">MNKRDVLKILSVIVLMLLVFTIILENPIKILLIIYEGNILLLFTFLLLMLSEVIKSFRLYYTCRFAKNCKLRLFDSIKIQLSSFFYGTITPGNIGGVPSMASLLNKYNQTPLGEAFGISSSQAFFDGIIPSLASFLFSLFYLPESLGITLFSLFTIIFWSLVFNINIKSFSIKILDKISIRNLKERIIKEIDTFQESLNFVKNKKLLFGSLIISIISYLIQTFSIMILLNKNISIFKLFIALMFNYAMAIFPTPAGEGGAEYGLAVLLPINIVVMWRLSYILSGLVSGLSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACL8</accession>
    <name>L0ACL8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl15</name>
        <name evidence="8" type="ordered locus">Calag_1171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232789.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1171"/>
    <dbReference type="EnsemblBacteria" id="AFZ70892">
        <property type="protein sequence ID" value="AFZ70892"/>
        <property type="gene ID" value="Calag_1171"/>
    </dbReference>
    <dbReference type="GeneID" id="14212431"/>
    <dbReference type="KEGG" id="clg:Calag_1171"/>
    <dbReference type="eggNOG" id="arCOG00779">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109163_0_0_2"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="OrthoDB" id="121171at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_prot_L15/27a_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="7">
        <location>
            <begin position="33"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="155" mass="17687" checksum="02975ECB05CFC5C0" modified="2013-03-06" version="1">MALTSRSRKKSRKLRGRTRSMGWGRVGQHRKSGSKGGTGGSGMNKHRKTWMLKYYPNWFGAKGFVPIRNRLLHKKNTITLRELDQIAFKLRNTNVEGDKVVLNLNEMGYDKLVANGKIYEKVKVIVKEATKKAIERVKEAGGEVIVEKIEEEEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACL9</accession>
    <name>L0ACL9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA helicase, Rad3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233066.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1466"/>
    <dbReference type="EnsemblBacteria" id="AFZ71169">
        <property type="protein sequence ID" value="AFZ71169"/>
        <property type="gene ID" value="Calag_1466"/>
    </dbReference>
    <dbReference type="GeneID" id="14212726"/>
    <dbReference type="KEGG" id="clg:Calag_1466"/>
    <dbReference type="eggNOG" id="arCOG00770">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006515_9_0_2"/>
    <dbReference type="OMA" id="QVNPVNE"/>
    <dbReference type="OrthoDB" id="31834at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="616" mass="70413" checksum="3993B32941947F74" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACM3</accession>
    <name>L0ACM3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L32e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232794.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1176"/>
    <dbReference type="EnsemblBacteria" id="AFZ70897">
        <property type="protein sequence ID" value="AFZ70897"/>
        <property type="gene ID" value="Calag_1176"/>
    </dbReference>
    <dbReference type="GeneID" id="14212436"/>
    <dbReference type="KEGG" id="clg:Calag_1176"/>
    <dbReference type="eggNOG" id="arCOG00781">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071479_3_1_2"/>
    <dbReference type="OMA" id="HPSGYEE"/>
    <dbReference type="OrthoDB" id="110802at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_L32e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_L32e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_L32e_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="PTHR23413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="SSF52042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="137" mass="15839" checksum="D4ECFC87EDE6D773" modified="2013-03-06" version="1">MSSEQIVKDILKQKRKIRESVSEKRRVHFMRYLSWRFKRLGDSWRKPKGIDAKMRLQRKGYPPIVKVGYKNKNSIRGLHPSGLIPVVISNKKELELLSPRAHIIYIDSSVGLKKRVELLKVAKEKGFKVANGGIYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACM5</accession>
    <name>L0ACM5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1088"/>
    <dbReference type="EnsemblBacteria" id="AFZ70810">
        <property type="protein sequence ID" value="AFZ70810"/>
        <property type="gene ID" value="Calag_1088"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1088"/>
    <dbReference type="eggNOG" id="arCOG01603">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_2_0_2"/>
    <dbReference type="OMA" id="NVIMIYH"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011894">
        <property type="entry name" value="PorC_KorC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02175">
        <property type="entry name" value="PorC_KorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="12"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="191" mass="20871" checksum="D8E4460D138A78BB" modified="2013-03-06" version="1">MTTIEIRWHGRGGQGAVTAGEVLASGAIIEGKYALAFPEFGAERRGAPVRAYTRITDNPNIPRTPIENPDVVVILDRSLLKKEYMEGLKKGGYIIANTPLKPDELIKKIDLPNSYNVSTVDATSIALKWLKANIVNTAILGAVIKTTNLIKIDTIIEVLKNRFHGKIGESNAMAVKEAYDSTLVMKLQEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACP6</accession>
    <name>L0ACP6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1108"/>
    <dbReference type="EnsemblBacteria" id="AFZ70830">
        <property type="protein sequence ID" value="AFZ70830"/>
        <property type="gene ID" value="Calag_1108"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1108"/>
    <dbReference type="eggNOG" id="arCOG15272">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_6_0_2"/>
    <dbReference type="OMA" id="WIRNMLY"/>
    <dbReference type="OrthoDB" id="35869at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_B_exo1" evidence="7">
        <location>
            <begin position="155"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B" evidence="6">
        <location>
            <begin position="532"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="947" mass="110069" checksum="E40005D5467D1F77" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACR3</accession>
    <name>L0ACR3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-hydroxyacid dehydrogenase, 3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233111.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1514"/>
    <dbReference type="EnsemblBacteria" id="AFZ71214">
        <property type="protein sequence ID" value="AFZ71214"/>
        <property type="gene ID" value="Calag_1514"/>
    </dbReference>
    <dbReference type="GeneID" id="14212775"/>
    <dbReference type="KEGG" id="clg:Calag_1514"/>
    <dbReference type="eggNOG" id="arCOG00247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_0_6_2"/>
    <dbReference type="OMA" id="IFVDHTT"/>
    <dbReference type="OrthoDB" id="92096at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="161"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ71214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="287" mass="31681" checksum="851798A1A00D7A5A" modified="2013-03-06" version="1" precursor="true">MKIGLIGLGVMGYRVAANLKNSNMLDYVYNKTESKAIDFSKKYNVTYLKNLTDLAKNSDFIITVLSDDYAVSSVIKEILPYLKNKILVDLSTISPTTSINLSEQVASNGGIMFDAPMIGTSVDVEQKRITIIVGGPKEKFDIVKDVLSNTSNKVIYAGKNGTGLYIKLAANMMFASFMSGLAEAVSFAEKAGISKEQITELFLNISSTRSPASNLKLPKMLNSDFETQFALKHMRKDTEIMVRESQNLKMPLPLTSLISNLLRISEGLGLGELDVSSIIEFYRKTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD86</accession>
    <name>L0AD86_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl24</name>
        <name evidence="5" type="ordered locus">Calag_1378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Located at the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="2">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232984.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1378"/>
    <dbReference type="EnsemblBacteria" id="AFZ71087">
        <property type="protein sequence ID" value="AFZ71087"/>
        <property type="gene ID" value="Calag_1378"/>
    </dbReference>
    <dbReference type="GeneID" id="14212638"/>
    <dbReference type="KEGG" id="clg:Calag_1378"/>
    <dbReference type="eggNOG" id="arCOG04094">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093240_2_1_2"/>
    <dbReference type="OMA" id="VRIMRGD"/>
    <dbReference type="OrthoDB" id="107015at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_L24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_L26/L24P_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="PTHR11143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="150" mass="17331" checksum="95586A3A5D4BD606" modified="2013-03-06" version="1">MISSSIPKKQRKYLFNMPLHLRHKLVTVKLSKELRNKFGIRNLPVKVGDKVRVVKGTHKGKTGKVTEVDLKRLFVKIEGIKRKKADGTEIPVKIRPWNLEIIDLDLKDEERKKIVQRRGGKMQETQSEFAKAQESSEEKSTEEKEVKTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADF9</accession>
    <name>L0ADF9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Elongation factor 1-beta</fullName>
            <shortName evidence="6">EF-1-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">aEF-1beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ef1b</name>
        <name evidence="8" type="ordered locus">Calag_1447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233049.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1447"/>
    <dbReference type="EnsemblBacteria" id="AFZ71152">
        <property type="protein sequence ID" value="AFZ71152"/>
        <property type="gene ID" value="Calag_1447"/>
    </dbReference>
    <dbReference type="GeneID" id="14212707"/>
    <dbReference type="KEGG" id="clg:Calag_1447"/>
    <dbReference type="eggNOG" id="arCOG01988">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165896_1_0_2"/>
    <dbReference type="OMA" id="VMPNSPE"/>
    <dbReference type="OrthoDB" id="124073at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00043">
        <property type="entry name" value="EF1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004542">
        <property type="entry name" value="Transl_elong_EF1B_B_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39647">
        <property type="entry name" value="PTHR39647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006521">
        <property type="entry name" value="Transl_elong_EF1B_B_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="SSF54984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00489">
        <property type="entry name" value="aEF-1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF1_GNE" evidence="7">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="91" mass="10056" checksum="DC0AD621CE006B2D" modified="2013-03-06" version="1">MARVAVLLKVMPNSLDIKLNDLKNEIMKSLPEGYKIIDSKEEPVAFGLKALILLVSMPENTEGGTEEIESLIRNVDGVEDVEVETVSRLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADJ6</accession>
    <name>L0ADJ6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit Rpo1C</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit A''</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpo1C</name>
        <name evidence="3" type="synonym">rpoA2</name>
        <name evidence="6" type="ordered locus">Calag_1501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1501"/>
    <dbReference type="EnsemblBacteria" id="AFZ71202">
        <property type="protein sequence ID" value="AFZ71202"/>
        <property type="gene ID" value="Calag_1501"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1501"/>
    <dbReference type="eggNOG" id="arCOG04256">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037097_1_0_2"/>
    <dbReference type="OMA" id="TPMMTVY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06528">
        <property type="entry name" value="RNAP_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00411">
        <property type="entry name" value="RNApol_arch_Rpo1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012757">
        <property type="entry name" value="RPO1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02389">
        <property type="entry name" value="RNA_pol_rpoA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb1_5" evidence="5">
        <location>
            <begin position="47"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="427" mass="47729" checksum="D8B5467F5C29299B" modified="2013-03-06" version="1">MSKMSPRKKKAEKTVEDYSNELEVKLNSSKEILPEKIYNELIEKLNKSNLNAKKKIEVVEETVRRYISSMIQPGEPVGTVAAQSIGEPGTQMTLRTFHYAGLMEFDVTLGLPRLIEIVDARHEPSTPIMRIYLDEENRNDLEKAKEIARRIEYTIISNVVSEISYVLGEPRIQIEIDKDMLEDKGVTPEEIIEAIGKLKIGEANVDENNPNIINVELSEDVMPEEELYDTKAFNEIISKIRKTYLKGVKGIKKTMIQEKGYEENGVKKKEYVILTEGSNLAEIMKIKGVDPGRIETNNIVEISQVLGIEAGRNAIIKEILDVLQNSGLDVDIRHVMLVADMMTWTGKIRQIGRLGVVGEKPSVIARAAFEVTINQIYNAAITGEDEKFFGVTESISAGLIPRIGTGIVMLGMGATPIKPSINNTENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADK6</accession>
    <name>L0ADK6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="9">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">carB</name>
        <name evidence="13" type="ordered locus">Calag_1512</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233109.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1512"/>
    <dbReference type="EnsemblBacteria" id="AFZ71212">
        <property type="protein sequence ID" value="AFZ71212"/>
        <property type="gene ID" value="Calag_1512"/>
    </dbReference>
    <dbReference type="GeneID" id="14212773"/>
    <dbReference type="KEGG" id="clg:Calag_1512"/>
    <dbReference type="eggNOG" id="arCOG01594">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_3_2"/>
    <dbReference type="OMA" id="IEPAGIH"/>
    <dbReference type="OrthoDB" id="911at2157"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_A">
        <property type="entry name" value="CPSase_L_chain_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="131"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="671"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="12">
        <location>
            <begin position="927"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="9">
        <location>
            <begin position="928"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="820"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="832"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="834"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ71212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="1046" mass="118226" checksum="62542E412E7BD15E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADS1</accession>
    <name>L0ADS1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Calag_1488</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233087.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1488"/>
    <dbReference type="EnsemblBacteria" id="AFZ71190">
        <property type="protein sequence ID" value="AFZ71190"/>
        <property type="gene ID" value="Calag_1488"/>
    </dbReference>
    <dbReference type="GeneID" id="14212748"/>
    <dbReference type="KEGG" id="clg:Calag_1488"/>
    <dbReference type="eggNOG" id="arCOG01181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_1_0_2"/>
    <dbReference type="OMA" id="GYTNFRE"/>
    <dbReference type="OrthoDB" id="74143at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="94"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ71190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="300" mass="35014" checksum="9EADC3E72E28EAF9" modified="2013-03-06" version="1">MGLSLKEKYYQMDNNDFKTLFLIEKFMRYYGFVPLEVLENKSNIPSNQIKKSIEKLLDLGLIISEASPFYGYQLTFNGLDILSLRFYFNKKIITDIGDKINSGKESDIYNAKLISEKNAIIKFHKEGRTSFKAIRRKRSFEFKKWNSWIELSKKVSNREFLTLSNLWKKGALVPEPIYVNRHSIIMEKIDGLELYKVKELSEEMVKNILDDVIATLRIAYKEVGIIHGDLSPYNILISNSENPRGYIIDWPQFIDVKNKYAESILRKELEYLASYFYKRFGIEVSVDNLMDSIKGGIDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7G0</accession>
    <name>L0A7G0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl CoA:acetate/3-ketoacid CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0012"/>
    <dbReference type="EnsemblBacteria" id="AFZ69808">
        <property type="protein sequence ID" value="AFZ69808"/>
        <property type="gene ID" value="Calag_0012"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0012"/>
    <dbReference type="eggNOG" id="arCOG01986">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026774_4_0_2"/>
    <dbReference type="OMA" id="GTDYNKR"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="556" mass="62050" checksum="5C522BCF47B6D23D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7U5</accession>
    <name>L0A7U5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0113</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EPSP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231799.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0113"/>
    <dbReference type="EnsemblBacteria" id="AFZ69901">
        <property type="protein sequence ID" value="AFZ69901"/>
        <property type="gene ID" value="Calag_0113"/>
    </dbReference>
    <dbReference type="GeneID" id="14211373"/>
    <dbReference type="KEGG" id="clg:Calag_0113"/>
    <dbReference type="eggNOG" id="arCOG04134">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024321_0_0_2"/>
    <dbReference type="OrthoDB" id="80060at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ69901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="407" mass="44974" checksum="C854D54214B7198E" modified="2013-03-06" version="1">MKVIILPSKISGEIDAPKSKSIAIRILFGSLLNNITLREEVPGSNDVKAAYNSIIEMGVYHEGNKLKKPYSINLNKKFFAGGSATVARILSSLILTLGGNAIIDGDETLRKRPFDGLIKLAKITNSEVNGNSLPIKLSSKGIKDYIEIPELESSQYITGLMYGFAYKGYGVIKLKSRVPSFSYIMLTMDLLNDIGCKIKYEDNEIVVEKCLKKDYETSFPGDYLLSSFYAVSSLLTGGLTIIHNLYKASNYFGDHKIVDILSDIGVKSKLDNGNWIIKSENLENLRVNVDDSPDMAMSLAPLGVKVEVTLDGINRLKIKESDRIKSIKDVMEKFGSIVSIKDNTINIKPNKINKAEIDCNNDHRVAMMAASISFLSGGIINNAECIGKSDPKHWDRYEKLGGKIKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7X9</accession>
    <name>L0A7X9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231876.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ69978">
        <property type="protein sequence ID" value="AFZ69978"/>
        <property type="gene ID" value="Calag_0196"/>
    </dbReference>
    <dbReference type="GeneID" id="25396754"/>
    <dbReference type="KEGG" id="clg:Calag_0196"/>
    <dbReference type="eggNOG" id="arCOG01644">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1590983_0_0_2"/>
    <dbReference type="OMA" id="WYWLGAI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010397">
        <property type="entry name" value="DUF996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06195">
        <property type="entry name" value="DUF996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="201" mass="22504" checksum="FDB400F450921144" modified="2013-03-06" version="1">MIKRKLSALDKHMDRLNSLNSSQNTGNQLGKYEIHDAANYGFYGSVLMFLGFIPFIGGFLLFIGFILILIALNDFSKIFNNKYIFENALYAVVAGIIISILVITVAPLGIFSGHITSTIIVVFILIYIASITSGYFYRNVYSSLADNIKNNLGNISNEEFQKASSWYWYGGLTTIILIGVIFILIADIYALLGYRELSKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7Z2</accession>
    <name>L0A7Z2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231849.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0165"/>
    <dbReference type="EnsemblBacteria" id="AFZ69951">
        <property type="protein sequence ID" value="AFZ69951"/>
        <property type="gene ID" value="Calag_0165"/>
    </dbReference>
    <dbReference type="GeneID" id="14211425"/>
    <dbReference type="KEGG" id="clg:Calag_0165"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_697573_0_0_2"/>
    <dbReference type="OMA" id="FGFHRMM"/>
    <dbReference type="OrthoDB" id="22281at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="378" mass="42493" checksum="0F001962052AA5BD" modified="2013-03-06" version="1">MIKKEVYKLSFSAFFADLGYQTAVVMFPLIFVIILKAPIWLYGIAEALNYGIGSLMGLIGGIMGDKFGRKKMAVLGNGLIIIISLLGFSKNLWEALLLFMIPWWFRNFRSPIRRAMLTEVTEESERSKAFGILHSLDLGGAVLAITYTTILLFFKFPIQYLLLITMVPLAISTYLLSISNSGKKVEKRKISFKSDNKIITLIVISTTLFGFTQYSFGFPIITTEFFTHQAYLSVISYGIFLSASSLFGFLLGRLRINNFFALGFIGYLLGSFSSLGFAQFSSYGIMAIYPFSFLLGVSIASTETFEPSIISRFSKSESMGSNMGLLTFGRSIGVFLSNMIMGLLYEIRYSYAYYFSSIMSIIAFIIVLYIIFKMRINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A828</accession>
    <name>L0A828_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231921.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0241"/>
    <dbReference type="EnsemblBacteria" id="AFZ70023">
        <property type="protein sequence ID" value="AFZ70023"/>
        <property type="gene ID" value="Calag_0241"/>
    </dbReference>
    <dbReference type="GeneID" id="14211501"/>
    <dbReference type="KEGG" id="clg:Calag_0241"/>
    <dbReference type="eggNOG" id="arCOG04283">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2204008_0_0_2"/>
    <dbReference type="OMA" id="DDLGMSW"/>
    <dbReference type="OrthoDB" id="119951at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="105" mass="12176" checksum="2E863E5AB358EEF7" modified="2013-03-06" version="1">MARIKKLILDTADFHPLHKMWVNLAQTLSKEYGIELEIKNEDYLFAISYGDKDDIGMAWLPQLFAELDDGRILLIMSQYPFDPSTTKPSEELAMKEAKKKIEEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A853</accession>
    <name>L0A853_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0229"/>
    <dbReference type="EnsemblBacteria" id="AFZ70011">
        <property type="protein sequence ID" value="AFZ70011"/>
        <property type="gene ID" value="Calag_0229"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0229"/>
    <dbReference type="eggNOG" id="arCOG01141">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_4_0_2"/>
    <dbReference type="OMA" id="ACGCATE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="4"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="174" mass="19896" checksum="5D6733964B9F2E5A" modified="2013-03-06" version="1">MNLMILGVISDTHDNLINLNKIINEMKKYNVDMLIHLGDFVSPFTLKKIGEELNNIKIYAVYGNNDGDKLYLKKIANEYKIVLEEQPLILKIDEHKLFIFHGYNSSEETVEIAKSIAKSKIYSAVFFGHTHKPYLDFINGILILNPGDASGILNRPTFALIKYPSFSPKIIYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0A863</accession>
    <name>L0A863_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isopentenyl-diphosphate delta-isomerase</fullName>
            <shortName evidence="7">IPP isomerase</shortName>
            <ecNumber evidence="7">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Isopentenyl diphosphate:dimethylallyl diphosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Type 2 isopentenyl diphosphate isomerase</fullName>
            <shortName evidence="7">IDI-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fni</name>
        <name evidence="9" type="ordered locus">Calag_0278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the IPP isomerase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="7"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0278"/>
    <dbReference type="EnsemblBacteria" id="AFZ70058">
        <property type="protein sequence ID" value="AFZ70058"/>
        <property type="gene ID" value="Calag_0278"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0278"/>
    <dbReference type="eggNOG" id="arCOG00613">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065515_1_0_2"/>
    <dbReference type="OMA" id="WDWGIPT"/>
    <dbReference type="OrthoDB" id="42330at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02811">
        <property type="entry name" value="IDI-2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00354">
        <property type="entry name" value="Idi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="PTHR43665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003314">
        <property type="entry name" value="IPP_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02151">
        <property type="entry name" value="IPP_isom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_dh" evidence="8">
        <location>
            <begin position="27"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="6"/>
            <end position="7"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="273"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="294"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="377" mass="41744" checksum="75BC3223752B0714" modified="2013-03-06" version="1">MSTTERKLEHIDIVVNENVQSRESTLLEYVRLIHNPLPEHDLNHIDLSKDFCGYTLSAPLVITGITGGHPDAEKINDAISKIVNKFNIAMGVGSQRAAIENSNLTHSFSIVRENAPNAFLIANIGVAQLNKGYGIKEFVKAIEMIKANAIAIHINPGQEAYQDEGDTDFSNLISKIEEINDQLNVPIIIKEVGNGLNKGIVRELRSIGIKCFDTAGLGGTNWIKTESIRSRKKHGFALKEPGKLADFWGNPTALSIIETRISAIDSYIIGSGGIRDGLDAAKAISLGADVAGMAFPILKILKIEGEKGIENYIKNVIYQIKTSIFLSGGENVYSLWKTPLTIWGRLKDELLMRGIEPNEYLNKRLYTKLWRMKDYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>L0A873</accession>
    <name>L0A873_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="5">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lysS</name>
        <name evidence="8" type="ordered locus">Calag_0288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 6">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231966.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0288"/>
    <dbReference type="EnsemblBacteria" id="AFZ70068">
        <property type="protein sequence ID" value="AFZ70068"/>
        <property type="gene ID" value="Calag_0288"/>
    </dbReference>
    <dbReference type="GeneID" id="14211548"/>
    <dbReference type="KEGG" id="clg:Calag_0288"/>
    <dbReference type="eggNOG" id="arCOG00408">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_2"/>
    <dbReference type="OMA" id="EIFGEKC"/>
    <dbReference type="OrthoDB" id="16292at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="173"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="495" mass="57773" checksum="5AF8C9A12270CF19" modified="2013-03-06" version="1">MEWDEERLKILKELRSKGINPYPQKFEFTHTIAQVIEEANKSNKKTHEPFLFNISTVGRVGNVRRHGKASFIDIFDEGEKLQLYARVNELGEERYNEFIHIIGRGDIIGVKGDLFYTMKGELTLRIKDYTLLSKALIEPPDWSKLTPEFRYAHRYVDFLYNSDARELMLKRFNIIQQIRSYLYKQGFMEVETPVLQPVYGGALAKPFKSHVNALNEDWYLRISLELYLKRYIVGGFNKVFEIGKVFRNEDIDVTHNPEYTLMELYWAYADYKDIMNLTENLIREVARSVLKEPKIKKVINGKEYEIDLDKPFNKVTMYDALSNAIGKNIETVSDDELKRMLDEIGQKPRGNLYIRGFMIEKLFDKLVADNIIEPTFILDYPIETTPLCKPHRSKPGLVERFELYAVGMELANAYTELNDPVLQDELFKKEMEMMKRGDEEAHPYDFDFVRALSYGMPPTGGVGIGIDRLVMLLTGVYSIKEIIPYPMISYKLIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8A9</accession>
    <name>L0A8A9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin converting factor, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0309"/>
    <dbReference type="EnsemblBacteria" id="AFZ70088">
        <property type="protein sequence ID" value="AFZ70088"/>
        <property type="gene ID" value="Calag_0309"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0309"/>
    <dbReference type="eggNOG" id="arCOG00536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2055947_0_0_2"/>
    <dbReference type="OMA" id="YIIKENF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="119" mass="13827" checksum="07B8F4E30A5AB8C7" modified="2013-03-06" version="1">MNSKNYPNLDRSLYQYNFKNFQGLLFYGDKMKINILFGGIYSQMAKFDKATIEIDTNYIDMEKLIYIIKENFKIDIKNDIEKGQALILVNGRNIKYIDKIKLNEGDFISLLPPVKGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8I3</accession>
    <name>L0A8I3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small GTP-binding protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232029.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0355"/>
    <dbReference type="EnsemblBacteria" id="AFZ70131">
        <property type="protein sequence ID" value="AFZ70131"/>
        <property type="gene ID" value="Calag_0355"/>
    </dbReference>
    <dbReference type="GeneID" id="14211615"/>
    <dbReference type="KEGG" id="clg:Calag_0355"/>
    <dbReference type="eggNOG" id="arCOG00352">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011784_0_0_2"/>
    <dbReference type="OMA" id="DPSEYCG"/>
    <dbReference type="OrthoDB" id="66209at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="164"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="340" mass="39306" checksum="A60F20CF746C1451" modified="2013-03-06" version="1">MKETIMDPAEIVKEIQIPLYDEIMEKIKSRYSKKGGKQYEKEIKSIELIYNIINSKTESIVELEKMLKKLHNFYWGLIEANYDKKKIFESIECIKKSRFFVRKFWVDYRNKILASDTPKEMRMLSREARGRMISSIKKCSKSLEYLRNLVITIMSFPGLDPSRKTLIIAGPPNAGKSTIVSSITNANTKVASYPFTTKEIIIGHLEYDKNNVIQIVDTPGLLDRSINEMNEIEKKAISALTHLDGIIIFILDPSKDAYMPLEEQFNIINNIKKLIINKKIILIINKIDLLNDNELKALDHLLNEYLEKLNIKEFYKISALDKKILLNTINNIVKSSLLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8J0</accession>
    <name>L0A8J0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KaiC domain protein, PAE1156 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232081.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0414"/>
    <dbReference type="EnsemblBacteria" id="AFZ70183">
        <property type="protein sequence ID" value="AFZ70183"/>
        <property type="gene ID" value="Calag_0414"/>
    </dbReference>
    <dbReference type="GeneID" id="14211674"/>
    <dbReference type="KEGG" id="clg:Calag_0414"/>
    <dbReference type="eggNOG" id="arCOG01171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_2_0_2"/>
    <dbReference type="OMA" id="EKMRQTN"/>
    <dbReference type="OrthoDB" id="76011at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022443">
        <property type="entry name" value="KaiC-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03881">
        <property type="entry name" value="KaiC_arch_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="261" mass="29795" checksum="D201077675F92362" modified="2013-03-06" version="1">MSLVKIERLATGVKGFDKLISGGIPRGFFVAVVGEPGTGKTIFGIHYAWQGVKENDKIIYVTTEESRESIIRQAKMFGMNLDEAVDSNKMIIIDALMKNTNDEWTLNETDIDELVKKIIDAKKKLGYGRARLVIDSMSTFWLDKPAMARIYSYNIKRVLYKWDFTALLTSQYAITTSSAFGWGVEHVADGIIRFGRRIVGGELKRYVLVEKMRQTPHDLRVHYITIEDKIGMKIEEATELRQEDVSMPEKLKKQLKNHEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8J5</accession>
    <name>L0A8J5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0419"/>
    <dbReference type="EnsemblBacteria" id="AFZ70188">
        <property type="protein sequence ID" value="AFZ70188"/>
        <property type="gene ID" value="Calag_0419"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0419"/>
    <dbReference type="eggNOG" id="arCOG15169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3038850_0_0_2"/>
    <dbReference type="OMA" id="SETICGE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="54" mass="6779" checksum="9F19723577895758" modified="2013-03-06" version="1">MPKKDEEEFEDLDDEEEFEEEDEEEFEDLDDEEEFEEEESEEEESEEESEEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8U1</accession>
    <name>L0A8U1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232164.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70266">
        <property type="protein sequence ID" value="AFZ70266"/>
        <property type="gene ID" value="Calag_0501"/>
    </dbReference>
    <dbReference type="GeneID" id="14211761"/>
    <dbReference type="KEGG" id="clg:Calag_0501"/>
    <dbReference type="eggNOG" id="arCOG01426">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064028_0_0_2"/>
    <dbReference type="OMA" id="NRNTEAI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="242" mass="28229" checksum="00A33A6DA7120E72" modified="2013-03-06" version="1">MSNTLSKEEKLRILKSIETDQEFRYSLLGALGLTEILNRLDTHAKNQENILAEIKKIWEEVKELKEGQNKLWEEVKELKATQNEILKEIAKLWQAVGDLRKDVNELKETTKNMQKTLERLTLTVEDESKEVIAYRIANELNEKINLERIFIDDEEINIYGVTDDLFVIGEATVRLGVSLIDELERKIDKIKKNRPDLIRKKMIKVIYFDIATPDSIELARKKGIWLLTIKGDITQRIIHETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8U8</accession>
    <name>L0A8U8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231742.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0052"/>
    <dbReference type="EnsemblBacteria" id="AFZ69844">
        <property type="protein sequence ID" value="AFZ69844"/>
        <property type="gene ID" value="Calag_0052"/>
    </dbReference>
    <dbReference type="GeneID" id="14211312"/>
    <dbReference type="KEGG" id="clg:Calag_0052"/>
    <dbReference type="eggNOG" id="arCOG12274">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2874887_0_0_2"/>
    <dbReference type="OMA" id="RWMRELN"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="63" mass="7476" checksum="98EE61CB288AB4C7" modified="2013-03-06" version="1">MEDSVKEAKKLLDETIELAKKIYGKRWMRELNMIEDRFGGDPYDVLEFLKKEAENKGIKLDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8W9</accession>
    <name>L0A8W9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="11">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ctaB</name>
        <name evidence="12" type="ordered locus">Calag_0541</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cell membrane</location>
            <topology evidence="3 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="11"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232199.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0541"/>
    <dbReference type="EnsemblBacteria" id="AFZ70301">
        <property type="protein sequence ID" value="AFZ70301"/>
        <property type="gene ID" value="Calag_0541"/>
    </dbReference>
    <dbReference type="GeneID" id="14211801"/>
    <dbReference type="KEGG" id="clg:Calag_0541"/>
    <dbReference type="eggNOG" id="arCOG00479">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029631_0_1_2"/>
    <dbReference type="OMA" id="QFFWQFP"/>
    <dbReference type="OrthoDB" id="97092at2157"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="283" mass="30943" checksum="E2FC119F8DD10B47" modified="2013-03-06" version="1" precursor="true">MSFIKKAKALFNMTKPAQMGLLLITVYGAYFAAGTSINIRNLLLLLPVGIGGIGGVTALNMYLEVDIDSIMARTRKRPLPSKQLSNTEAIVGIILLILIGIIAADFINKYVVFAIIMGLFFDIIGYTELTKRTTATNILFGGIAGAMPSLGGWAAATGYYGIGGILLALIVLAWIPMHIWFIVYYNIDDYKNASIPMLPVISNEKTFGNIVVFSIISLAILSWLFYFLEGRGMIAASLSTILVIIALLKINKFMRYPSKNNALSVFKFANSVIAVVFVLARFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A920</accession>
    <name>L0A920_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type branched-chain amino acid transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0633"/>
    <dbReference type="EnsemblBacteria" id="AFZ70388">
        <property type="protein sequence ID" value="AFZ70388"/>
        <property type="gene ID" value="Calag_0633"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0633"/>
    <dbReference type="eggNOG" id="arCOG01020">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_4_1_2"/>
    <dbReference type="OMA" id="GPSHWEP"/>
    <dbReference type="OrthoDB" id="35461at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="52"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="430" mass="46503" checksum="7D8D9456AB336133" modified="2013-03-06" version="1">MDKVGNRAISRGALIGIIVVIIVVIIVGGVAYYYSTKKPTSTTSTVSAPPYILIGTLYASSGSYASSSMPEYEGLQLWAKWVNESGGIYVKEYGKKIPVKIVAYDDQSNPTTAQSLYQQLVTVNHVNVLVADFGSVLTAPAVTYANASHILLWDVTGSSYAFFINNPYIILTSLPVSPYFITYVAPFLHSLNITKVAVIYAANDFNAYQDYFLGTYFKQYGITAVVNESFPTSTTDFSSYIATIESAKPQAVLELGYPTDDIPFLNQVASSGYHFPMVLTNFPGQLLPDFLSAVGANMNGTFTLAYPPLVSYTPNYGPNLTEFYKLWNSTYPTIPPNFLSIAGFNAGLIIGLAIQDAGTLNQTAIKAAVLNDISGKITTIDGLFNVTQYGMQVGENPLPAQVWVYPNGTANVVLLWPPNLATGKAVYPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0A956</accession>
    <name>L0A956_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0681"/>
    <dbReference type="EnsemblBacteria" id="AFZ70428">
        <property type="protein sequence ID" value="AFZ70428"/>
        <property type="gene ID" value="Calag_0681"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0681"/>
    <dbReference type="eggNOG" id="arCOG00245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1084248_0_0_2"/>
    <dbReference type="OMA" id="IVAVPFW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="266" mass="31039" checksum="8C65933FCE3E1704" modified="2013-03-06" version="1">MRVGIIGYGKMGQVFSNLFQKHGYNVIIYDTKLKHEKFKNFIKKSDYIMISVSPNNLKRVINRLINISKLGYLDGKLIFDISTFKDDIIHYYSKFSDKVMIGSIHPLFGPGIKDPSKHYIAIIPLKENDGSKILEDIFSNMGFKVFYVNYKTHDELISITIGLSYIIGISINKMLNSYDKKMIENLSGTTFKYLKNHYLSIYNDIPDFANYILSNKRVKNTLKNYINVLKELEKNKEDVLKELEKNKNDIEIRNAYNSLYDCIEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A991</accession>
    <name>L0A991_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase, glucoamylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232366.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0723"/>
    <dbReference type="EnsemblBacteria" id="AFZ70468">
        <property type="protein sequence ID" value="AFZ70468"/>
        <property type="gene ID" value="Calag_0723"/>
    </dbReference>
    <dbReference type="GeneID" id="14211983"/>
    <dbReference type="KEGG" id="clg:Calag_0723"/>
    <dbReference type="eggNOG" id="arCOG03285">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_441225_0_0_2"/>
    <dbReference type="OMA" id="WYTRYNF"/>
    <dbReference type="OrthoDB" id="5867at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="587" mass="67543" checksum="1030D198A3CB0EBF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9A7</accession>
    <name>L0A9A7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0711"/>
    <dbReference type="EnsemblBacteria" id="AFZ70456">
        <property type="protein sequence ID" value="AFZ70456"/>
        <property type="gene ID" value="Calag_0711"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0711"/>
    <dbReference type="eggNOG" id="arCOG06081">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2433666_0_0_2"/>
    <dbReference type="OMA" id="RIYFTEF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="82" mass="9886" checksum="C7EA95A17C456D85" modified="2013-03-06" version="1">MHKKLYRIYFTEFDEENFRKIINALEEKYSSQINVIKSNVIDEFRALELYFEKEGYSDEIKNLISSLTGTQYVRVDYIDTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9C8</accession>
    <name>L0A9C8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TsaA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232400.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0759"/>
    <dbReference type="EnsemblBacteria" id="AFZ70503">
        <property type="protein sequence ID" value="AFZ70503"/>
        <property type="gene ID" value="Calag_0759"/>
    </dbReference>
    <dbReference type="GeneID" id="14212019"/>
    <dbReference type="KEGG" id="clg:Calag_0759"/>
    <dbReference type="eggNOG" id="arCOG00761">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013458_2_0_2"/>
    <dbReference type="OMA" id="VCRLEIF"/>
    <dbReference type="OrthoDB" id="117039at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818">
        <property type="entry name" value="PTHR12818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="SSF118196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="160" mass="18559" checksum="307ACC7367B779C7" modified="2013-03-06" version="1">MRNSQIVLKPIGEVINDHSDEEVRNSLFGVHGKILIYDDYKDGICCLEGFSHIIVIGYAHKLKEEDKKVLKVRLRKIERLYNIQTPEVGVFSSGSPARPNLLIVSILKLININNNVLEVDNLDMYDKTPILDIRPFTIERIPQEEIKVPEWYEKIFNKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9D5</accession>
    <name>L0A9D5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231932.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0252"/>
    <dbReference type="EnsemblBacteria" id="AFZ70034">
        <property type="protein sequence ID" value="AFZ70034"/>
        <property type="gene ID" value="Calag_0252"/>
    </dbReference>
    <dbReference type="GeneID" id="14211512"/>
    <dbReference type="KEGG" id="clg:Calag_0252"/>
    <dbReference type="eggNOG" id="arCOG00895">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1259044_0_0_2"/>
    <dbReference type="OMA" id="DPLCGMK"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="219" mass="25081" checksum="017AA5C53E7B87A0" modified="2013-03-06" version="1">MTYNEISVVTTTYNEEENIGELIKRIRGLGFKVYMIVVDDSSTDNTAKISYMLANKTIVKKREGQTIGLWYGILNSKDNIVVTIDADLENPPELIPFMLNEFIKNDCGVLVASRDRLPRFSEKMSSKIFKKIIKVNDVYSNFRIYKKQCLNGFTPRLGETFGLELLLFLKKNKCKFCEFTYHAPPRRANPRIGGKVKANIRALNSTLKSLIGDLIYYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9I5</accession>
    <name>L0A9I5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232428.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0789"/>
    <dbReference type="EnsemblBacteria" id="AFZ70531">
        <property type="protein sequence ID" value="AFZ70531"/>
        <property type="gene ID" value="Calag_0789"/>
    </dbReference>
    <dbReference type="GeneID" id="14212049"/>
    <dbReference type="KEGG" id="clg:Calag_0789"/>
    <dbReference type="eggNOG" id="arCOG08854">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1418623_0_0_2"/>
    <dbReference type="OMA" id="IKWIDIS"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="197" mass="23192" checksum="86D3F1EDE8CFB98F" modified="2013-03-06" version="1">MAKSQKSKEQKFKAIVQWFKKETIDLEEISFDGYKLINVEEIESKEDPLNFLYNLAEEKRKEKKGDFFVINVESLETKYVFADGVKDRGRLLYNIPIKLKRVGLIKKNQLKMSPEGYFIFKNDDIKWIDISNEIYIYYGTLKANDDIELVVLDTEKDKRIIKTQHLSMMKLSSPTPEQQNQSDHNNENELDEDNNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9L0</accession>
    <name>L0A9L0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR00266 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231987.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0310"/>
    <dbReference type="EnsemblBacteria" id="AFZ70089">
        <property type="protein sequence ID" value="AFZ70089"/>
        <property type="gene ID" value="Calag_0310"/>
    </dbReference>
    <dbReference type="GeneID" id="14211570"/>
    <dbReference type="KEGG" id="clg:Calag_0310"/>
    <dbReference type="eggNOG" id="arCOG01907">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040551_4_1_2"/>
    <dbReference type="OMA" id="ICQKDAF"/>
    <dbReference type="OrthoDB" id="90481at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00266">
        <property type="entry name" value="TIGR00266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="220" mass="24045" checksum="4EC7E722464D4AE4" modified="2013-03-06" version="1">MKYETIGSEFQYLLVDLQPGEEIYVDGSHVIYKDKSVTLNAKMVGGFLSALKREITGTTFFLLEAIGPGKIALSSPLAGKVVKIDLGNRGILVEHTSFLASENTVKYESKLGSLTAGLFGGEGIFLAKLEGKGSVFLHAVGQVNELYLNNQELQVEAAHLLAFEEGLNYGITRVGNLKTMLFGDEGLFFVNLSGTGKVWVKSSSRRDVALSIYKYLPRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9L1</accession>
    <name>L0A9L1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0282 protein Calag_0034</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0282 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0034"/>
    <dbReference type="EnsemblBacteria" id="AFZ69827">
        <property type="protein sequence ID" value="AFZ69827"/>
        <property type="gene ID" value="Calag_0034"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0034"/>
    <dbReference type="eggNOG" id="arCOG00969">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079268_0_0_2"/>
    <dbReference type="OMA" id="YHYDHHT"/>
    <dbReference type="OrthoDB" id="36408at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01406">
        <property type="entry name" value="UPF0282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014426">
        <property type="entry name" value="UPF0282_hydrls"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF4">
        <property type="entry name" value="PTHR43546:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004944">
        <property type="entry name" value="UCP004944_hydrls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="296" mass="33681" checksum="04DA8E124FE1FE80" modified="2013-03-06" version="1">MKFIKIGKFNVSILGSDSFGVRSLATFVNVCNKNIGIDLGASLAPRRYGLPPHKIELERLSKVLLEIENAINISDYIIITHYHYDHYIKDKPNLYYGKTLFIKDPKKNVNRSQSYRAKVFLIDNEVQNKANVNIADNNKFDFGDLKLEFSNALWHGEDKTKVGKLVMARIICNDQSIIFGSDTQGPGNQEALEKLIEWKGAELLIISGPPTYFAGYKVSQESVEKGLENMKSLIEKHVSKIIIADHHLLRDIHYKDILKDHYKLANDNGVSLITAAEFMGYPIDQLEARRKELWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9N6</accession>
    <name>L0A9N6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232490.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70593">
        <property type="protein sequence ID" value="AFZ70593"/>
        <property type="gene ID" value="Calag_0852"/>
    </dbReference>
    <dbReference type="GeneID" id="14212112"/>
    <dbReference type="KEGG" id="clg:Calag_0852"/>
    <dbReference type="eggNOG" id="arCOG00349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_9_1_2"/>
    <dbReference type="OMA" id="PRESCMP"/>
    <dbReference type="OrthoDB" id="111853at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="89" mass="10079" checksum="AF21B85FA6FD46FC" modified="2013-03-06" version="1">MTIKVWIEPRENCIADMVCVSLCPDVFQMNEIDGKAEIVNKWRPDPDKKEQGTRSEGTVPDELQDCVDAASQSCPTQIIHYSKDGQQMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9N7</accession>
    <name>L0A9N7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232495.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0858"/>
    <dbReference type="EnsemblBacteria" id="AFZ70598">
        <property type="protein sequence ID" value="AFZ70598"/>
        <property type="gene ID" value="Calag_0858"/>
    </dbReference>
    <dbReference type="GeneID" id="14212118"/>
    <dbReference type="KEGG" id="clg:Calag_0858"/>
    <dbReference type="eggNOG" id="arCOG00020">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035788_0_0_2"/>
    <dbReference type="OMA" id="AWIEIPA"/>
    <dbReference type="OrthoDB" id="64383at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019293">
        <property type="entry name" value="ThiN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10120">
        <property type="entry name" value="ThiP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="1">
        <location>
            <begin position="17"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="460" mass="50772" checksum="5F2DD41F4E0EF315" modified="2013-03-06" version="1">MNKYKQIPVALTIAGSDSGGGAGIAADLKTFASLGVHGTVAITSVTAQNTYEVTGIYDVTPDMVRKQIEAVYNDFGIDAAKTGMLSNALIVEEVANTLKSYDFPLVIDPVMVSKSCAPLLREDAVNILIKKLIPRATVITPNIPEAEKITNMKILNLDDARKAAKIIVEEFGAKAAIVKGGHMKGEESIDVLYYNGEFREFVGKRINTKSDHGTGCSFSASITANLAKGYGIVESIKIAKELISNAIFYGLPLGKGHGPVNPISYMEIPYHKYMVYIEMKNALKLLDEKQELIAKLIPEISTNLAMALPRFYARSIDDVIAVPGRIRKFKDKLIFAKEPEFGASDHVARALLKFMDYFPEYRSAANIAYNDDIKRIIEKLNFSYSYYDRKYEPKDVKEKEGGSMQWGIEFAIKNMSIKNMSNPLDIIIDYGDFGKEPGAIIFGKTANEVVGKMIKIAELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9R2</accession>
    <name>L0A9R2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232525.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0888"/>
    <dbReference type="EnsemblBacteria" id="AFZ70628">
        <property type="protein sequence ID" value="AFZ70628"/>
        <property type="gene ID" value="Calag_0888"/>
    </dbReference>
    <dbReference type="GeneID" id="14212148"/>
    <dbReference type="KEGG" id="clg:Calag_0888"/>
    <dbReference type="eggNOG" id="arCOG06083">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_951883_0_0_2"/>
    <dbReference type="OMA" id="AYYSALM"/>
    <dbReference type="OrthoDB" id="109298at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="292" mass="32362" checksum="998B4F76B2E87C3C" modified="2013-03-06" version="1">MVSMLITGSTIFTGKELIKEGYVFIKDGKIKEIGTQPVPDEISEPSLLLGGKGRIVAPSLSAIADIPIFLMRFYKLKMNKRIEFYKMLTQRDLFTLSLPAIYELNMHGITTIFAEAINISYVLDLKDKIGGYYGIAKPACIKDLKIPPSLIGEIDVKGFGCDGEGISDNDSKYLLLLGKNSYSISGIDNIYEKSEKLRSLAGLPPNVIKENNNAEIVIYDTSKPPAMNFYKCDLDCIKNVYNENAIIESLIAGEDVLVDIGGHLRIGQKHLKEAESLAEKIANDEKFRQILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9S1</accession>
    <name>L0A9S1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal flagella assembly protein J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232535.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0899"/>
    <dbReference type="EnsemblBacteria" id="AFZ70638">
        <property type="protein sequence ID" value="AFZ70638"/>
        <property type="gene ID" value="Calag_0899"/>
    </dbReference>
    <dbReference type="GeneID" id="14212159"/>
    <dbReference type="KEGG" id="clg:Calag_0899"/>
    <dbReference type="eggNOG" id="arCOG01809">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036985_0_0_2"/>
    <dbReference type="OMA" id="KWGDAYI"/>
    <dbReference type="OrthoDB" id="8691at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="546" mass="60905" checksum="5A1C37139A64CB31" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9T2</accession>
    <name>L0A9T2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-dehydroquinate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231800.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0114"/>
    <dbReference type="EnsemblBacteria" id="AFZ69902">
        <property type="protein sequence ID" value="AFZ69902"/>
        <property type="gene ID" value="Calag_0114"/>
    </dbReference>
    <dbReference type="GeneID" id="14211374"/>
    <dbReference type="KEGG" id="clg:Calag_0114"/>
    <dbReference type="eggNOG" id="arCOG02097">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064444_2_0_2"/>
    <dbReference type="OMA" id="MNRPLIV"/>
    <dbReference type="OrthoDB" id="75928at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="205" mass="24167" checksum="E8F47D4DEC456328" modified="2013-03-06" version="1">MNRPLIVLSLPYGNIDEYVNKTDLIEIRLDYKKNLSVDDIDNFLKFKDKIIITIRDINEGGIFPIKEETKIRIYKKLYDYGIIYDLEQRFLEKYDLPYENKIVSVHYLNNLPSFNEILEKFKKYNDLFTAKLAVRNIKGYKSILIKFLEVIENATAIPLGANWYERVAFSLLGSKLLYVYDKIQTGEGQPKLEDAMNIMKNIFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9T8</accession>
    <name>L0A9T8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232555.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0927"/>
    <dbReference type="EnsemblBacteria" id="AFZ70658">
        <property type="protein sequence ID" value="AFZ70658"/>
        <property type="gene ID" value="Calag_0927"/>
    </dbReference>
    <dbReference type="GeneID" id="14212187"/>
    <dbReference type="KEGG" id="clg:Calag_0927"/>
    <dbReference type="eggNOG" id="arCOG02742">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_718870_0_0_2"/>
    <dbReference type="OMA" id="EYYETRE"/>
    <dbReference type="OrthoDB" id="48221at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="168"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="384" mass="44903" checksum="EA648DF2D4DD3E89" modified="2013-03-06" version="1" precursor="true">MIGKIFLIFSLFLIAFGISFKIIDFLVISSLILTFSIIDYLSIRKPRFYLKPLINYLEMKRGEEYSLILHIEGDRKGEELIPPFSFCKINEDNSKNSFIMIIKPNKSGIYELNSLKVKKKSFLFEKTFLVNVNPPVKFSVYPKSLTKIREFLSLGIGYTNPSNITGLGEEYAYTDELRSGDDTRRIDWKKTAKTGKIMVKKFYWDLYGGSSIIIDLESTDENSADDIATEALNALRFSYYMNSKVYIYDGEKIKSVNKNIYNALLLILDMLKKYYPEYNRLLDYYKKKTEKIKENIKDLDYMRSGDTKVIIVSQLLSDLIFKIKELFNEKVMGIIIQPSKPWIYIDDIEVSYNIRKRYEINYEYAKNNGFEIFKSFNEIGGLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9U6</accession>
    <name>L0A9U6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCA-adding enzyme</fullName>
            <ecNumber evidence="8">2.7.7.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCA tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA CCA-pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA adenylyl-/cytidylyl- transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA-NT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cca</name>
        <name evidence="11" type="ordered locus">Calag_0426</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">A single active site specifically recognizes both ATP and CTP and is responsible for their addition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="8"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232092.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0426"/>
    <dbReference type="EnsemblBacteria" id="AFZ70194">
        <property type="protein sequence ID" value="AFZ70194"/>
        <property type="gene ID" value="Calag_0426"/>
    </dbReference>
    <dbReference type="GeneID" id="14211686"/>
    <dbReference type="KEGG" id="clg:Calag_0426"/>
    <dbReference type="eggNOG" id="arCOG04249">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044679_1_0_2"/>
    <dbReference type="OMA" id="DVDLVPC"/>
    <dbReference type="OrthoDB" id="82755at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01264">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008229">
        <property type="entry name" value="CCA-adding_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042090">
        <property type="entry name" value="CCA_tRNA_nucleotrans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006116">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015329">
        <property type="entry name" value="tRNA_NucTransf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39643">
        <property type="entry name" value="PTHR39643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09249">
        <property type="entry name" value="tRNA_NucTransf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005335">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="SSF55003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03671">
        <property type="entry name" value="cca_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0692">RNA repair</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="9">
        <location>
            <begin position="46"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTransf2" evidence="10">
        <location>
            <begin position="156"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="453" mass="51817" checksum="7FFECDF832BF8F9B" modified="2013-03-06" version="1">MSCNRNDLEENILNQIKPTPFQIKILERFSNIIKRKISYCMKGNGLDGVVEEVGSFAKGTLLNDKWELDIFVLLKDIDNEWINNNGKNFLLSCLNDFPTIIKYSQHPYVTVSYMGLEADVVPTVFVEKPRKNGMGVERTPFHTRYINSKLNACQKDDVRLLKSFFKGLSIYGAESHIEGFSGYLSELLIAYYGNFFNALKNISGWKDLIYIDIEGNGNRDVLIKRYPQSKLIVVDPIDPYRNVAAAVSQKSISTLILASKLFLEKPNIVFFHKFSHNVKSNIDTPLLLTIGHGVYYNYPPTDIWGKLKKITENLENKINELGIGIIKSSYYTNESNLIAIGFLIDRDALPKTDIMEGPSVYDDINSIKSFIKKRLDEKGIVYINDSKVYGGRNKKIKDLIDFVNNSVMESGIKFNNKIETRVYNNFDDIDIKGEIKEWIKNSLYSIPAWMINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9U8</accession>
    <name>L0A9U8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231815.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0129"/>
    <dbReference type="EnsemblBacteria" id="AFZ69917">
        <property type="protein sequence ID" value="AFZ69917"/>
        <property type="gene ID" value="Calag_0129"/>
    </dbReference>
    <dbReference type="GeneID" id="14211389"/>
    <dbReference type="KEGG" id="clg:Calag_0129"/>
    <dbReference type="eggNOG" id="arCOG01279">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_2_2_2"/>
    <dbReference type="OMA" id="SFREMMF"/>
    <dbReference type="OrthoDB" id="44046at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="384" mass="42371" checksum="814C673857B5E68E" modified="2013-03-06" version="1">MSRVAIVGAGWYGFKPTTIDVSFQDMMFESSSRAYASANIDPRYDIDAFVDCQEDMWEGIAIADEFAPEPIGGALRPTFTVAGDGLEGIAHAYMLIKTGHFNVVSVESHGKPSEIKTLQDIYRFALDPLHVRPLDTGNPLFYAGLDAVAYMKRTNTKREHLAMVAVKNKNNGLRNERASFSTKIDLDNVLSSSYSIYPLSNYEIAPFSDASITFVLASEEYAKKFTDTPVYIEGIGYSTETGTGATEWHEWGKMRSIREAALMAYKLANLNGNPQVDFAEVEDRFSYMELLSLEESLIVKEGEAHELLENGEFNFNGSLPVNPSGGSLSMGVQLEATGLSRLLESYLQLTGKAGSHQLKNVRRSLVVSWRGVPTYTSMVALLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9V2</accession>
    <name>L0A9V2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231733.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0043"/>
    <dbReference type="EnsemblBacteria" id="AFZ69835">
        <property type="protein sequence ID" value="AFZ69835"/>
        <property type="gene ID" value="Calag_0043"/>
    </dbReference>
    <dbReference type="GeneID" id="14211303"/>
    <dbReference type="KEGG" id="clg:Calag_0043"/>
    <dbReference type="eggNOG" id="arCOG03639">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086262_0_0_2"/>
    <dbReference type="OrthoDB" id="97733at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="249" mass="28093" checksum="83B4ED9031060BA7" modified="2013-03-06" version="1">MCRLFIANAKGSFIEKLYNSLMNAAGNDIFAKGLTHDTGWGYYIANSNISNFYKSGSPIFKDKISLNIDEDKNYHAIFHARLAAKGQPIRGFIDSHPYLIHNKDSLLILAHNGVVDKEIISKELNVDYRLYTDSEILGLLLSKFDGDIDKILYDADKYIKEIGAFIGTFNVIAMKIKRDQDNIKISSACISDYPDNKEDNYKKMVIYKNGDNIAAMSSTVAYYYGILDENGNIIDKNSMICEKGISYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9V7</accession>
    <name>L0A9V7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232575.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0950"/>
    <dbReference type="EnsemblBacteria" id="AFZ70678">
        <property type="protein sequence ID" value="AFZ70678"/>
        <property type="gene ID" value="Calag_0950"/>
    </dbReference>
    <dbReference type="GeneID" id="14212210"/>
    <dbReference type="KEGG" id="clg:Calag_0950"/>
    <dbReference type="eggNOG" id="arCOG00159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_2"/>
    <dbReference type="OMA" id="YIVFQRQ"/>
    <dbReference type="OrthoDB" id="46692at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="91"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="303" mass="33523" checksum="D7EB91F18FCC925E" modified="2013-03-06" version="1">MGSEIGDKKYKSENYYFRVIKYAILQLVAAALVILWLIPLYALFIGGLKSNIAAASTPALLPPSKPSGEAFYFVWHGFGGIYGLIGLEYPLIREALIALPVAALATLLGTMGAYFFYIIMDRHYILSTIGFAIISLATYLPIETTTVPLIQIVSSLHIYNTYYGVIFAYFMFYTPMAALLMSIFMPSIPKYLLEAAKIDGSNDWIVFWKVMMPLLVPGFLSTFIFTFLEIWNNFFIPILLVSNPNLMLLSIGVRQYAGGYAIIYNRSFAAGVIGSIVPLVIFILLGRYFIRGLAALGGGAKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9W5</accession>
    <name>L0A9W5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231830.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0146"/>
    <dbReference type="EnsemblBacteria" id="AFZ69932">
        <property type="protein sequence ID" value="AFZ69932"/>
        <property type="gene ID" value="Calag_0146"/>
    </dbReference>
    <dbReference type="GeneID" id="14211406"/>
    <dbReference type="KEGG" id="clg:Calag_0146"/>
    <dbReference type="eggNOG" id="arCOG00509">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017490_0_0_2"/>
    <dbReference type="OMA" id="VPWLHWP"/>
    <dbReference type="OrthoDB" id="72715at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="38"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="396" mass="45976" checksum="8EE45C2709AB1AA9" modified="2013-03-06" version="1">MENKFIKTKIAENLYLLRVSDNDTKYFEALWEIPEGIMYNAYLIKTKEGNVLIDGWKKPYSEKLLELLKEDLKDLKIIIVNHTEPDHSGSIKDILEYTKNKPLVLGTKMAGDLLKSFYKIDINFKQVEDGEEIKVGEYTLKFFTTPWLHWPDTMVTYVKELKFMFTCDIFGSYGIFDSVYADEINFDNYEPFIRKYTSTVIGAYKNYIVKNIDKIKNLGLEIKMILPGHGLLWRDPEKIIDYFYKIGNESIRSKKVTIIYNSMYGLIDPAILFTKEFIEKNGYETRVFKCTDKERPYISDIISETTDSSLIIYGISTYENDVFPIAKYILSMLSNKVNNKIPIIIITSYGWGPVVKQKVANIIKGTKFIIVDSIEFRGTNSKDDEKKIEEALAKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Y5</accession>
    <name>L0A9Y5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Looped-hinge helix DNA binding domain, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0075"/>
    <dbReference type="EnsemblBacteria" id="AFZ69865">
        <property type="protein sequence ID" value="AFZ69865"/>
        <property type="gene ID" value="Calag_0075"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0075"/>
    <dbReference type="eggNOG" id="arCOG00812">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_9_2_2"/>
    <dbReference type="OMA" id="DEFDEVW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="101" mass="11377" checksum="372EE7DA6B7043B5" modified="2013-03-06" version="1">MVQLSYTEGEPSLTLKLRIGRKGYIILPKAVREAVGIDEGDEVIVEINDGIVIKPAKKPVDKNTLKEAMRRHIEKLAEVPDHKEPRPGDMEGISLEEEFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA12</accession>
    <name>L0AA12_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trpF</name>
        <name evidence="6" type="ordered locus">Calag_0102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231788.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0102"/>
    <dbReference type="EnsemblBacteria" id="AFZ69890">
        <property type="protein sequence ID" value="AFZ69890"/>
        <property type="gene ID" value="Calag_0102"/>
    </dbReference>
    <dbReference type="GeneID" id="14211362"/>
    <dbReference type="KEGG" id="clg:Calag_0102"/>
    <dbReference type="eggNOG" id="arCOG01983">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076364_3_0_2"/>
    <dbReference type="OMA" id="SIMASEM"/>
    <dbReference type="OrthoDB" id="117266at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="196" mass="22721" checksum="A6B294D39572EF18" modified="2013-03-06" version="1">MTKLKICGVKYLEDVEFLNELKVDYIGMINEPNTPRYVDLEKIRKAINISKIPIVLVKSSINIDEIEKIPNEYIQIHRVLKDEELEMLSTIENKKVILYVPARLDYINYLKKAIKYTKFVLIDSFDKTISNINILKTMLEEYKEAGIAGGININNIYDYVKLEPGFIDISRGVEETTGKKSKEKVEFVLKVIKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA16</accession>
    <name>L0AA16_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type Fe3+-siderophore transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1021"/>
    <dbReference type="EnsemblBacteria" id="AFZ70743">
        <property type="protein sequence ID" value="AFZ70743"/>
        <property type="gene ID" value="Calag_1021"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1021"/>
    <dbReference type="eggNOG" id="arCOG01007">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_2_2"/>
    <dbReference type="OMA" id="WFAGSFT"/>
    <dbReference type="OrthoDB" id="36067at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="328" mass="35740" checksum="D0FE642FF5B80145" modified="2013-03-06" version="1" precursor="true">MKSINKILTVFLILLLPISFLLSLSIGPYSKVSIYQVIFFILGKNLPSTYIDILKYRLIRSLAALILGIGLSSSGLTLQYTLKNPLADPYLLGISSGAIFGVTIAMFFGYYSFYQLYIIALLSALLSLGFILLISTIFKSSSTTIIIAGISLSYLLNGITTIYMIRLGPKIPSILFWLFGSVAFTTLNTLEKSSILVIISLFFMFYYWKAINTLMLGEDVAKSLGVKVSYIRIVSVLFSSISTAALVAMAGPVGFIGLAAPWMARLIIGSNFGKALLMSLLTGSLLAIFSDILARLVIYPSEAPLTAITSIFGAPVLIYLTLKYKGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA27</accession>
    <name>L0AA27_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0988"/>
    <dbReference type="EnsemblBacteria" id="AFZ70711">
        <property type="protein sequence ID" value="AFZ70711"/>
        <property type="gene ID" value="Calag_0988"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0988"/>
    <dbReference type="eggNOG" id="arCOG01260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_2"/>
    <dbReference type="OMA" id="ARNYDEI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="261" mass="29497" checksum="B28A14A4E9029B1D" modified="2013-03-06" version="1">MIIMNNKCNALVTASTKGIGFQAALSLAEKGCNVVINARNYDEIKEAKKKLKRGRNKVYGIKGDLSKKNEIDKILDKALQKLGSIDVVVMNYGNPKCEPCNLVDADYNDWLYAFNMYIYSTAEAMNYLYKHNERKVNFIIISSFSIYSPMQSTALSDIIRISLLSLVKTYSKYYSDKIRANALLLGSFKTEGAENLIKKLSSNMGIDEQDFWDKYVKSLSPLNRLGRFEELRDVISFLAFSPEYLMGSLLLFDGGSLNCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA38</accession>
    <name>L0AA38_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase/AMP-acid ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231813.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0127"/>
    <dbReference type="EnsemblBacteria" id="AFZ69915">
        <property type="protein sequence ID" value="AFZ69915"/>
        <property type="gene ID" value="Calag_0127"/>
    </dbReference>
    <dbReference type="GeneID" id="14211387"/>
    <dbReference type="KEGG" id="clg:Calag_0127"/>
    <dbReference type="eggNOG" id="arCOG01529">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_2"/>
    <dbReference type="OMA" id="WWTISEL"/>
    <dbReference type="OrthoDB" id="24323at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="71"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="512"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ69915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="631" mass="71011" checksum="6939F812C8306B42" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA64</accession>
    <name>L0AA64_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232212.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0554"/>
    <dbReference type="EnsemblBacteria" id="AFZ70314">
        <property type="protein sequence ID" value="AFZ70314"/>
        <property type="gene ID" value="Calag_0554"/>
    </dbReference>
    <dbReference type="GeneID" id="14211814"/>
    <dbReference type="KEGG" id="clg:Calag_0554"/>
    <dbReference type="eggNOG" id="arCOG04243">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_2"/>
    <dbReference type="OMA" id="FMGQAEA"/>
    <dbReference type="OrthoDB" id="115425at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="150" mass="16775" checksum="4EB33888DD7FD562" modified="2013-03-06" version="1">MSNANVIISTGKRKKAVATAIIKPGNGKVKVNGVPAEIIPNVMAKTKILEPILLVGKEIRNLIDIEVKVNGGGVMGQAAAIRTAIARGLVSYFKCNDNSEECQKRNEIAERIKQIFEEYDRSMLSGDYRRTEPEKYMRYGARRGWQTSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA65</accession>
    <name>L0AA65_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231838.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0154"/>
    <dbReference type="EnsemblBacteria" id="AFZ69940">
        <property type="protein sequence ID" value="AFZ69940"/>
        <property type="gene ID" value="Calag_0154"/>
    </dbReference>
    <dbReference type="GeneID" id="14211414"/>
    <dbReference type="KEGG" id="clg:Calag_0154"/>
    <dbReference type="eggNOG" id="arCOG05991">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2115360_0_0_2"/>
    <dbReference type="OrthoDB" id="112617at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="114" mass="13477" checksum="67AC184C6CA9F1B7" modified="2013-03-06" version="1">MIQGRLIKVTGYYRDTSLIERVLSNFRKLLIDVYYINGMLTNDKGLYEIYLIVNENQNLNRAIINLKESVGIEYVDVLGEIKFDLNNDSYFKYFLENNFNKNFLNLIYRGELDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA79</accession>
    <name>L0AA79_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RecA-superfamily ATPase possibly involved in signal transduction</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231848.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0164"/>
    <dbReference type="EnsemblBacteria" id="AFZ69950">
        <property type="protein sequence ID" value="AFZ69950"/>
        <property type="gene ID" value="Calag_0164"/>
    </dbReference>
    <dbReference type="GeneID" id="14211424"/>
    <dbReference type="KEGG" id="clg:Calag_0164"/>
    <dbReference type="eggNOG" id="arCOG01174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_2_1_2"/>
    <dbReference type="OMA" id="LMDYVWI"/>
    <dbReference type="OrthoDB" id="55361at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="295" mass="33562" checksum="9554321F06BCA3E4" modified="2013-03-06" version="1">MSQTNNFTFGIEELDNLLNNIEQGNVILIAGNPGAGKTTFASKIAYENMKKYNSKTIYISFIEGKNEFFRNMKSLGLDFNEFENKGLFNFLEEITFTNKEMIPDLLNQFIDIIDKINAKILIIDSITSLIQLSHSIIHLREILHNFLYRISKTKGITSILIEEIPYGSEKIGIGIEEFLVDTIILLKAINLKGKIVRVAEIRKARRSNISLTTIPFIIKYDKAISLLYPKKFNRVAKHKIIKIVLDNNDFYIDTGSQNLIIVHPKINPFSLASLIILGTLIGTPSLLENIRRKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA84</accession>
    <name>L0AA84_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gamma-aminobutyrate permease-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231853.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0170"/>
    <dbReference type="EnsemblBacteria" id="AFZ69955">
        <property type="protein sequence ID" value="AFZ69955"/>
        <property type="gene ID" value="Calag_0170"/>
    </dbReference>
    <dbReference type="GeneID" id="14211430"/>
    <dbReference type="KEGG" id="clg:Calag_0170"/>
    <dbReference type="eggNOG" id="arCOG00009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_16_0_2"/>
    <dbReference type="OMA" id="AFWSGWP"/>
    <dbReference type="OrthoDB" id="15038at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="509" mass="54838" checksum="A2F46C50DEC4A782" modified="2013-03-06" version="1">MGENSKGASLRKELSFLEIFIAGLVGAVGTGILFSPAGMAGYAGPSIIISWILGGIFYTFVSIPIIELELVWPEAGGPARYPLYTHGNILNLISSFMNLVWYLFIPPIEALATVEGLAYFFPNLLVPGTTIPTVLGAIVGTLLLLLFVPFNYFGVKAFGRTTLGLGLIKLIIYIVAALSIAVVFFSPGNFIKTPGGFAPFGFSGIFLAIPLAMFAYGGIRVIPDFAEEVKDKSFLGKAILLTVLGQTIIYILFSIVFIGGLNWSALGIKFGDWSSVSSLPGNPFIDISSSLHSKLSLLLVLIVAILGPFVTGYIYLGSGTRVVFAISRSGYMPDKLKEVSATYAIPYWALIIFAIVGAILTFLTAPIHAIYSLLEDAVVGGYLAFATLPVTMMAARKKNITPKNYRLPLGWVWAVLAFISSSLIAFWSGWPSVPYAIAIGLIASIVFGLIFKVKGEFRKSIWYIVYLIFILIMTYIGSDGALSIIGFIPATIIVAVVSVLVFLPWGVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA86</accession>
    <name>L0AA86_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Calag_1054</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232673.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1054"/>
    <dbReference type="MEROPS" id="M01.020"/>
    <dbReference type="EnsemblBacteria" id="AFZ70776">
        <property type="protein sequence ID" value="AFZ70776"/>
        <property type="gene ID" value="Calag_1054"/>
    </dbReference>
    <dbReference type="GeneID" id="14212314"/>
    <dbReference type="KEGG" id="clg:Calag_1054"/>
    <dbReference type="eggNOG" id="arCOG02969">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_3_2"/>
    <dbReference type="OMA" id="FIPCVDH"/>
    <dbReference type="OrthoDB" id="3866at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="11">
        <location>
            <begin position="13"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="9">
        <location>
            <begin position="203"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="10">
        <location>
            <begin position="483"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="775" mass="89790" checksum="D988B69652CD8D39" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA93</accession>
    <name>L0AA93_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1064"/>
    <dbReference type="EnsemblBacteria" id="AFZ70786">
        <property type="protein sequence ID" value="AFZ70786"/>
        <property type="gene ID" value="Calag_1064"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1064"/>
    <dbReference type="eggNOG" id="arCOG05321">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155017_0_0_2"/>
    <dbReference type="OMA" id="DDEYINW"/>
    <dbReference type="OrthoDB" id="139360at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="121" mass="13728" checksum="A2C5DCFC9CC400A3" modified="2013-03-06" version="1">MSCMSLDIKSLLSLPENKREETLKSIFSSLLGLQQDQVVNALTDFLKGLQTYANDNQYKEVCKTNLKIISSLPDNVAKQVIAMRLQAQNNLPENMKNRDKKVLNDAINESPYKEKILKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAB0</accession>
    <name>L0AAB0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1084"/>
    <dbReference type="EnsemblBacteria" id="AFZ70806">
        <property type="protein sequence ID" value="AFZ70806"/>
        <property type="gene ID" value="Calag_1084"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1084"/>
    <dbReference type="eggNOG" id="arCOG00358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_1_2"/>
    <dbReference type="OMA" id="SAKHPGQ"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="PTHR43127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="87"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="MMR_HSR1_Xtn" evidence="3">
        <location>
            <begin position="209"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="2">
        <location>
            <begin position="313"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="381" mass="42830" checksum="324FDA77CDEF6D54" modified="2013-03-06" version="1">MVYEMVTNLPAEAIAKLNKYSDAKTVEDKIKALEEFISAVPKHKGTENLLYWARSRLAELRQEEEKERRKKKGGGPRIFIEKAGAGQIAIIGPPNSGKSSLMSRLTNAKVVISPNPFSTTDPIPGMMQYEDIQFQLIDTPPIISNEGNYVNTRVLAIARNSDAIIIVIGLDDENYLNTLKRVIDTLEKRGIMISMQKGYIRIIKHRSGNGINVVFYGKPKFTEEDVKKALSSYRIFNATVEIYGEPSLDDIDASLINAITYKPTIVLFNKKDLNNFKGADLPKDVLYKVVSAKTGEGLEDLGKDIFNILKIKRIYTKKPNAPPDKDPLIIREDATIREIAETINHSNIKYAKIWGKGAKYDGQRVGPDFIPKDKDIVEIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAB4</accession>
    <name>L0AAB4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232745.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1126"/>
    <dbReference type="EnsemblBacteria" id="AFZ70848">
        <property type="protein sequence ID" value="AFZ70848"/>
        <property type="gene ID" value="Calag_1126"/>
    </dbReference>
    <dbReference type="GeneID" id="14212386"/>
    <dbReference type="KEGG" id="clg:Calag_1126"/>
    <dbReference type="eggNOG" id="arCOG04291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046519_0_1_2"/>
    <dbReference type="OMA" id="YLRMHGR"/>
    <dbReference type="OrthoDB" id="61105at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="231" mass="27632" checksum="1ECC38B6517806BF" modified="2013-03-06" version="1">MEIFVGTSGWMYSWNKGRSLDWYIKESGFNTVELNASFYRFPYKNQIKSWSEKGSSLRWAIKVHKSVSHTHRLNKDAIEVFKKFLDAFSVMDNITSFYLIQLPPSFNKNDENLDRLLSFIKEANLGRRLAIEFRHKTWFNEDTIDLFNRLETTFVSVSSPIIEYIAKTNDIIYLRMHGKTKWYYYEYSEEELNYIAKTIINLNPKEVYVYFNNDLWMLSNGQYLMNLMKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAB9</accession>
    <name>L0AAB9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232750.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1131"/>
    <dbReference type="EnsemblBacteria" id="AFZ70853">
        <property type="protein sequence ID" value="AFZ70853"/>
        <property type="gene ID" value="Calag_1131"/>
    </dbReference>
    <dbReference type="GeneID" id="14212391"/>
    <dbReference type="KEGG" id="clg:Calag_1131"/>
    <dbReference type="eggNOG" id="arCOG04166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093718_0_0_2"/>
    <dbReference type="OMA" id="YAAFYSA"/>
    <dbReference type="OrthoDB" id="57080at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018693">
        <property type="entry name" value="DUF2192"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09958">
        <property type="entry name" value="DUF2192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="255" mass="29516" checksum="8B0A752CBB34DA34" modified="2013-03-06" version="1">MEKEGKDLKKRKSILMDLWNDLITIWESNPKKVTREYVIERLKNEYNKEKISPIKGATDPKDLYDKEMTSLYVLGKYGMGLEIQYPELFDLVFAQEIKMDQINEILLSDNLDGGKDKILAIIGGINGNTIAKIMRLGVTKEYFGFIDQRSVVKLADSLKKLFPNQENEVNKYMKFYAAFKISKAIDDGTVRNRIMKEALRQALAIELNIDKKNMPRDNYIMKVASGSFNIPKKVIRQIFPYNKSKKLNKNENKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAE2</accession>
    <name>L0AAE2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Single-stranded DNA-specific exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232292.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0639"/>
    <dbReference type="EnsemblBacteria" id="AFZ70394">
        <property type="protein sequence ID" value="AFZ70394"/>
        <property type="gene ID" value="Calag_0639"/>
    </dbReference>
    <dbReference type="GeneID" id="14211899"/>
    <dbReference type="KEGG" id="clg:Calag_0639"/>
    <dbReference type="eggNOG" id="arCOG00426">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_907931_0_0_2"/>
    <dbReference type="OMA" id="IHHWDAD"/>
    <dbReference type="OrthoDB" id="39370at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="356" mass="39569" checksum="6C75A94C4C0B70F3" modified="2013-03-06" version="1">MQLENKQLMRLISNSNPLIIHHWDADGVISATTLASYIGQGIDFESPPFRYSLDKNYLELLSLRSENHDVVIIVDLNLPSKALMEISVSTNKPVISIDHHTTNDIPKSLSIVYYNPAKNGDPEGLWPSAAHVIALLTGTYDPLLISTSIIGDLDNEAKNNRIFKKYMDEIGLDPENDFNIPKECAMQVWGAEALGKIDIIKNLPTVLAYGGIDPCAALMRDPVLTMLKNEAEEELSNLISKADAQLEKVFDYFYAVLINGNGRLISKISRTLASKYPDKLIMIGYLAKSTNDASIYIRTKRNDINFSAISEKIKKLGYQVGGKNQANNNVIGVEIKPESLNEAYNNIVEVIKKELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAF9</accession>
    <name>L0AAF9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GINS complex subunit Sld5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0663"/>
    <dbReference type="EnsemblBacteria" id="AFZ70414">
        <property type="protein sequence ID" value="AFZ70414"/>
        <property type="gene ID" value="Calag_0663"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0663"/>
    <dbReference type="eggNOG" id="arCOG00552">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117967_0_0_2"/>
    <dbReference type="OMA" id="MQISERR"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld5" evidence="2">
        <location>
            <begin position="23"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="167" mass="19372" checksum="998A5539DA64A3BB" modified="2013-03-06" version="1">MKKDYILSLSGGTINAKKGDEIDLPRWQALYLKSIDVADIKEEEVDINYLNSYHFKEKRNQAPNQLSPLPQDFYIKISSFIKSLDKAISQNPTHMLINDREAAEKNFIELSESRLLKLIRLSQTNGDDLRDRMTPEEFLIYSTIKNIIFSWRSYILNLSKGGVNNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAM5</accession>
    <name>L0AAM5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232865.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70968">
        <property type="protein sequence ID" value="AFZ70968"/>
        <property type="gene ID" value="Calag_1251"/>
    </dbReference>
    <dbReference type="GeneID" id="14212511"/>
    <dbReference type="KEGG" id="clg:Calag_1251"/>
    <dbReference type="eggNOG" id="arCOG11238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1773057_0_0_2"/>
    <dbReference type="OMA" id="EVYAMAN"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="146" mass="15739" checksum="813A710AF2C6563E" modified="2013-03-06" version="1" precursor="true">MRKNRAVSNIVAEIMMILITLAIGFTLIVYLSSAAGGFISLTNSNNNQAQISLQQYIVPMGSYISNGNLYFIFNSGPMGAQINSVYINNTLINSCSILFNKTSYSLPHYIPPDAVAIIKCTNVKSLPSIITVAYSGGEVYAMANPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAN0</accession>
    <name>L0AAN0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methionine synthase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">metE</name>
        <name evidence="4" type="ordered locus">Calag_1257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the archaeal MetE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232870.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1257"/>
    <dbReference type="EnsemblBacteria" id="AFZ70973">
        <property type="protein sequence ID" value="AFZ70973"/>
        <property type="gene ID" value="Calag_1257"/>
    </dbReference>
    <dbReference type="GeneID" id="14212517"/>
    <dbReference type="KEGG" id="clg:Calag_1257"/>
    <dbReference type="eggNOG" id="arCOG01876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040013_3_2_2"/>
    <dbReference type="OMA" id="DPDCGMR"/>
    <dbReference type="OrthoDB" id="21172at2157"/>
    <dbReference type="UniPathway" id="UPA00051"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00288">
        <property type="entry name" value="MetE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022921">
        <property type="entry name" value="MetE_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="3">
        <location>
            <begin position="9"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="330" mass="38502" checksum="7F06FCA8B58EA613" modified="2013-03-06" version="1">MSYEVPKKFPTTVVGSYPKLGNASEIIKKRDRNEISEGEFHEKIRDSINEVVKDYLDAGIDIISDGEQSREDMVVYFAQRLKGYNEGDWVRIFDNVYFRKPVIVGKLERIKEMIITDWLYTNKISNGRPVKLIITGPYTMLEWSFDLFYGDRREIIMDFAKIIREEILEGIRNGAKYVQVDEPALSTRPWKEEADLLKEALDYIFKGIDAKRIVHICYGKLERLLPYILDYPVDQFDLEFKNSNFRLLPYLKEYGYNKELGYGVVDVHSLQVESVNEIKEAIDKLMKLDIIGPEKVYIDPDCGLKLLPRDIAKEKLINMVKAAKIAREQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAP1</accession>
    <name>L0AAP1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-hydroxyacid dehydrogenase, 3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232391.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0750"/>
    <dbReference type="EnsemblBacteria" id="AFZ70494">
        <property type="protein sequence ID" value="AFZ70494"/>
        <property type="gene ID" value="Calag_0750"/>
    </dbReference>
    <dbReference type="GeneID" id="14212010"/>
    <dbReference type="KEGG" id="clg:Calag_0750"/>
    <dbReference type="eggNOG" id="arCOG00247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_0_4_2"/>
    <dbReference type="OMA" id="AWVQSTT"/>
    <dbReference type="OrthoDB" id="92096at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="164"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="294" mass="32474" checksum="637329E841D408EE" modified="2013-03-06" version="1">MTVRIAVLGTGNMGSAIAERLANTGFTIFLWNRTIDKAKSLASKINATVYETPWRAIENADVAITLVSDDNALYDIISQMRRSDGLLFINSSTITPKASMVASKQLKELGACYVEAPIIGNPHDLIQGNVIFLVAGERNCVRYSMGILMSAGKIIEIEGESYKASIAKLIYNSMLISSIQLLSESLTLADAYGISQEKVKEIMENTIFKQFVGKYLDRIINENHPTSFKISLAAKDLEYANSAAFDANLVLPLIRTSAQTFKQADIFGLNESDYTKIFNFINPKKFKKISNSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAV4</accession>
    <name>L0AAV4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232155.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0491"/>
    <dbReference type="EnsemblBacteria" id="AFZ70257">
        <property type="protein sequence ID" value="AFZ70257"/>
        <property type="gene ID" value="Calag_0491"/>
    </dbReference>
    <dbReference type="GeneID" id="14211751"/>
    <dbReference type="KEGG" id="clg:Calag_0491"/>
    <dbReference type="eggNOG" id="arCOG10275">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_682572_0_0_2"/>
    <dbReference type="OMA" id="NIMKIAM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="393" mass="43940" checksum="905DCC6F0FCD33B1" modified="2013-03-06" version="1" precursor="true">MIKKKLFVALIMLLIPFISITGMAQSLSYSISNTSVTINNQYYQIYFNLSNGATITSWKTLVPQVNQFNSVEIPSMVVSLNESIPGNLYNKAWKASLINKNSNYVKVVMTPVNNINNVSVYEFITASNYYPYINYEIIVNTTANESYIKDLYIAIGGNYDNNSWSFVVSSLENGIPNYYVTNSSGSYSGNIMKIAMFSYSSKAYNSIIGLNFISPVQANLQFLKGFINGTLESNIAYTIIDIKNITLSRGNSYEISFNLYDAQFNPELISLTDSTDMASQVYNINGNITNLVNYQTMIKSYLNNITSLNQSVNSLETKVGELQGLVSYWQVRYNETNQLAGSYSTRLHKSGEVSIGLFILGLVIGVLGGAYFLKPKPLETVPSRQQKKETKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAW9</accession>
    <name>L0AAW9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(FAD)-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0508"/>
    <dbReference type="EnsemblBacteria" id="AFZ70272">
        <property type="protein sequence ID" value="AFZ70272"/>
        <property type="gene ID" value="Calag_0508"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0508"/>
    <dbReference type="eggNOG" id="arCOG01069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_2_2"/>
    <dbReference type="OMA" id="ITHAPCG"/>
    <dbReference type="OrthoDB" id="40511at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="1">
        <location>
            <begin position="338"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="462" mass="50372" checksum="045E620F3635669E" modified="2013-03-06" version="1" precursor="true">MQKIVIIGAGAGGMAVASRAKRLNNSLNVTVLEKTNYASFALCGIPYYIGNIVKELDDLLFYPPEEFTKRGIDLKFGKEVTEVDVENKTLRFRDLKTGKEETISWDKLVLATGAKSKVSKIWPEINNAKNIFYITHLDSGEIIRNYALNLGKGKKAIIIGSGYVGLELIENLINLGLKVTVIEALNQILPRMLDPDLAGIVEDYLKTKGVEIIKNSPVESFEIQNNLAVKVKTSNGNFDGDMFVIGIGIEPNNDLAKQMKLNLGNSGGVIVNEKLLTNNPDVYAVGDVTEHKDLITGKYVWRPFAQIANKMGYIAGSNIGGMEAEFRGSVGTSALKAFDIIIARTGLSKAEAEKLGFKPIEASMNAGIRAHYIPGGENKIYLKIVADNKTGKLLGAQAIGPGESVFWRVNVIASLLTIKGTIWDLFNSDIGYQPTLSPAWDPLIIASRLLMRDLGEKPPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAX7</accession>
    <name>L0AAX7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidyl aminopeptidase/acylaminoacyl peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0828"/>
    <dbReference type="EnsemblBacteria" id="AFZ70569">
        <property type="protein sequence ID" value="AFZ70569"/>
        <property type="gene ID" value="Calag_0828"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0828"/>
    <dbReference type="eggNOG" id="arCOG01646">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03383">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_2_2_2"/>
    <dbReference type="OMA" id="YEMQLMA"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="409"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="621" mass="71600" checksum="10EFCF0BA0762B89" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAZ5</accession>
    <name>L0AAZ5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232481.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0843"/>
    <dbReference type="EnsemblBacteria" id="AFZ70584">
        <property type="protein sequence ID" value="AFZ70584"/>
        <property type="gene ID" value="Calag_0843"/>
    </dbReference>
    <dbReference type="GeneID" id="14212103"/>
    <dbReference type="KEGG" id="clg:Calag_0843"/>
    <dbReference type="eggNOG" id="arCOG02008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080422_2_0_2"/>
    <dbReference type="OMA" id="GGMERMI"/>
    <dbReference type="OrthoDB" id="88126at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="179" mass="19844" checksum="DECB2DC52D9A7072" modified="2013-03-06" version="1" precursor="true">MNKEKLSGILIFLGVSQFLLFMIVSEALYPGYSVSKNYISDLGVGSTAYIFNTSIIIMGLLLIISSFFLKNKILQVFLILSGIGAAGVGIFPETSPYHLHTLMSLVVFLFSSLSSYVAFTYRSNKNYLWPIMGSIGLISLILYILKIYGPIDYGGMERLIVYPNLIWALGFSGFLMSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB35</accession>
    <name>L0AB35_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232255.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0600"/>
    <dbReference type="EnsemblBacteria" id="AFZ70357">
        <property type="protein sequence ID" value="AFZ70357"/>
        <property type="gene ID" value="Calag_0600"/>
    </dbReference>
    <dbReference type="GeneID" id="14211860"/>
    <dbReference type="KEGG" id="clg:Calag_0600"/>
    <dbReference type="eggNOG" id="arCOG00498">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061754_0_0_2"/>
    <dbReference type="OMA" id="HSHADHC"/>
    <dbReference type="OrthoDB" id="99711at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="15"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="296" mass="32853" checksum="81DAB580315E037A" modified="2013-03-06" version="1">MGLENIKGNTFLYKGSPATLFYKDEENNVYIIDPGQGSKRPKELKSMLNKLNPKKSIAFITHYHSDHIAVLGEGFSVNEIVVSEIDAPAVRDPSLRALLTFGYMLNHEDNILPFKAKAINPTKLIGKDQNTYGPLQLIPLPGHTQGQLGVITPDGVLYAADSLFGDKVLTKYGIPYHQYPCKSVESLNLILNMLSKVDIIVPSHGPIVNSSEASQLIESNIKKITEIEEEIKKLLVEPMCLSSITQKLTSIYKSEEPSIGAYLLAENTIRGYISCLRQQGLIEAINDNNIKWKITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB50</accession>
    <name>L0AB50_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mercuric reductase</fullName>
            <ecNumber evidence="6">1.16.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Hg(II) reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">Calag_0616</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + Hg + NADP(+) = Hg(2+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23856"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16170"/>
            <dbReference type="ChEBI" id="CHEBI:16793"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232270.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="SMR" id="L0AB50"/>
    <dbReference type="STRING" id="1056495.Calag_0616"/>
    <dbReference type="EnsemblBacteria" id="AFZ70372">
        <property type="protein sequence ID" value="AFZ70372"/>
        <property type="gene ID" value="Calag_0616"/>
    </dbReference>
    <dbReference type="GeneID" id="14211876"/>
    <dbReference type="KEGG" id="clg:Calag_0616"/>
    <dbReference type="eggNOG" id="arCOG01068">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_1_1_2"/>
    <dbReference type="OMA" id="MSKHYDY"/>
    <dbReference type="OrthoDB" id="19112at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016152">
        <property type="term" value="F:mercury (II) reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045340">
        <property type="term" value="F:mercury ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050787">
        <property type="term" value="P:detoxification of mercury ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021179">
        <property type="entry name" value="Mercury_reductase_MerA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02053">
        <property type="entry name" value="MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="16">
        <location>
            <begin position="2"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="15">
        <location>
            <begin position="328"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFZ70372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="450" mass="49109" checksum="0E37D4FF9FEAD723" modified="2013-03-06" version="1">MKDLVIIGYGAAGFAALIKANELNVKPVLIGEGPIGGTCVNVGCVPSKKLLSIGEIYYKSRKHLKLNIYPPFFETFKEKDNLVSNLRKMKYEDVISSSDVELIEGKAKFISPHEVKVGNKIIEGKKFIIATGSSPKIPRIPGLDKIGYWTNNEALSPDRKIDSLAIIGGGPLGLEFAQMYKRLGVDVIVLEALPVLLYGWEPEISLEAEKILENEGISVVTNVNIKEIKKGSGKVIVTNKGEVEVDEILVATGRKPNTDLDLEKANVDLNENKGIKVDEELRTSNKDIYAAGDVIGSKMLEALAGKQGTVAAENALLDSHKKIDMLSVPQVVFLQPNIASVGLTEAEAEKIYRIETSKIMMEDLPKANILGENEGFIKMIIEEETKKILGVHLVSENGAEIINEASLAIKMRANINDLIDTIHVFPTMGEAIRLAALSFISDIKKMSCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB61</accession>
    <name>L0AB61_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Elongation factor 2</fullName>
            <shortName evidence="7">EF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fusA</name>
        <name evidence="9" type="ordered locus">Calag_1421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1421"/>
    <dbReference type="EnsemblBacteria" id="AFZ71128">
        <property type="protein sequence ID" value="AFZ71128"/>
        <property type="gene ID" value="Calag_1421"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1421"/>
    <dbReference type="eggNOG" id="arCOG01559">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_1_2"/>
    <dbReference type="OMA" id="GVMTQTE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_A">
        <property type="entry name" value="EF_G_EF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004543">
        <property type="entry name" value="Transl_elong_EFG/EF2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00490">
        <property type="entry name" value="aEF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="22"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Diphthamide" evidence="7">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ71128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="740" mass="82350" checksum="73AF756F9D38ECDC" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB62</accession>
    <name>L0AB62_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type 2 DNA topoisomerase 6 subunit A</fullName>
            <ecNumber evidence="6">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Type II DNA topoisomerase VI subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">top6A</name>
        <name evidence="8" type="ordered locus">Calag_1392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232998.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1392"/>
    <dbReference type="EnsemblBacteria" id="AFZ71101">
        <property type="protein sequence ID" value="AFZ71101"/>
        <property type="gene ID" value="Calag_1392"/>
    </dbReference>
    <dbReference type="GeneID" id="14212652"/>
    <dbReference type="KEGG" id="clg:Calag_1392"/>
    <dbReference type="eggNOG" id="arCOG04143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037229_1_0_2"/>
    <dbReference type="OMA" id="NWGEARF"/>
    <dbReference type="OrthoDB" id="22842at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00132">
        <property type="entry name" value="Top6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004085">
        <property type="entry name" value="TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="PTHR10848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01552">
        <property type="entry name" value="TPISMRASE6A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="SSF56726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TP6A_N" evidence="7">
        <location>
            <begin position="75"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="385" mass="44933" checksum="5B0FF1E2972C8682" modified="2013-03-06" version="1">MSHIDKIDIAARKKVAEIFHKKFSELHEEISKENPPKLEIPMRTLANTVFDPNKGILKLGIRKIERNFLNMNESKKFMQTLLMASIIYQALVENEYPTIRDLYYRGKHTILYKDLNGKLKEENTWEEQSESDASIRDVEVMLGLLREDMLILSKEKGKVVGNMRIRSGNDVIDLSKLGHGAYAIESTPDLIEFLDYDAEMVLVVEKDAVFQQLHRAGFWQKYKALLVTGAGQPDRATRRFVRRLHDELKLPVYILTDSDPYGWYIYSVFKVGSIQLSYESERLATPKAKFLGVSMSDIFGYGTKKAYLSEEERRNFIIKAKDVDIKRAKELMRYSWFHSKLWKREIDMFMDKKAKLEIEAMASKGLKFLAFQYIPEKIQTNDWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB65</accession>
    <name>L0AB65_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232285.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0632"/>
    <dbReference type="EnsemblBacteria" id="AFZ70387">
        <property type="protein sequence ID" value="AFZ70387"/>
        <property type="gene ID" value="Calag_0632"/>
    </dbReference>
    <dbReference type="GeneID" id="14211892"/>
    <dbReference type="KEGG" id="clg:Calag_0632"/>
    <dbReference type="eggNOG" id="arCOG04119">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120784_0_0_2"/>
    <dbReference type="OMA" id="HGTIYYE"/>
    <dbReference type="OrthoDB" id="108731at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018700">
        <property type="entry name" value="DUF2204"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09970">
        <property type="entry name" value="DUF2204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="186" mass="21660" checksum="6E7081262D09DB33" modified="2013-03-06" version="1">MVSLKAFVEILRKLLDEGVKFTIIGDTVILLNIKSEDLGEDIDLFVESPSILENENFYEELSNKNKWSYGKTWLGTPRITAVIFNEEINLDLYENLYDFYIPNSFINNAQRIDINGLRLKTISIEQYLVLKSYSGKEEDIEKLKDILNIIKKNKIRIHEDKIVEAAKEVGEENTILRKLKELGYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB89</accession>
    <name>L0AB89_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF302 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233055.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1454"/>
    <dbReference type="EnsemblBacteria" id="AFZ71158">
        <property type="protein sequence ID" value="AFZ71158"/>
        <property type="gene ID" value="Calag_1454"/>
    </dbReference>
    <dbReference type="GeneID" id="14212714"/>
    <dbReference type="KEGG" id="clg:Calag_1454"/>
    <dbReference type="eggNOG" id="arCOG02761">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116237_2_0_2"/>
    <dbReference type="OMA" id="VFARINH"/>
    <dbReference type="OrthoDB" id="113019at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="SSF103247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="1">
        <location>
            <begin position="33"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="134" mass="15677" checksum="B42C169BC3B25218" modified="2013-03-06" version="1">MIITYKSKYDFNELKIKLESSIIKKGMRIFSIIDHSKNAVSVGMKMNRSLLYIFGNPRNGTLLMYKDMRIGIILPLKILIWEDENKNLLISYFTIYETLKSFKLKDEELEIAKNIDINIIDILKDLGNEVDKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB90</accession>
    <name>L0AB90_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232581.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0956"/>
    <dbReference type="EnsemblBacteria" id="AFZ70684">
        <property type="protein sequence ID" value="AFZ70684"/>
        <property type="gene ID" value="Calag_0956"/>
    </dbReference>
    <dbReference type="GeneID" id="14212216"/>
    <dbReference type="KEGG" id="clg:Calag_0956"/>
    <dbReference type="eggNOG" id="arCOG00393">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055387_2_0_2"/>
    <dbReference type="OrthoDB" id="74894at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="412" mass="48193" checksum="B49C0FB994C5F41D" modified="2013-03-06" version="1">MEYPKISVIVTAHNRKKYLPYALQSLEKQTLDKDKFEVIVIKNFEDQLSDKIIERNNWKNIVIEENNTLGEKLSLGIDESKGDIITFLEDDDMYKPERLMYIYKSFQKIKNLIYISNDVDVIDENNNIIDKKFFAIKPSFNIIMKSDDPRWEKIIAKYEIYSNNSSIAVNRNIAENIKGLKGGMIDLAIMAISSFSEGLLFYTSKRLTYYRVHINKNVLKNQNSYEQLYNTNTSFTFLANYQSFQTDISFFKKFQSNCEKSSNVFCEKLAFDYLANIRALNLDSKQLKLPISQWRLLKFSLLGSILSNTSLFNMFINLATLSFFVFNKNLPSRLSLFITNIKDKINKYLDDEDKLILYTIKKNRGIMDINEIMIKTNINKNKLNRKLSKLIDLGYLEKVSFLKAEVYKIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB99</accession>
    <name>L0AB99_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:ubiquinone oxidoreductase 27 kD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1429"/>
    <dbReference type="EnsemblBacteria" id="AFZ71136">
        <property type="protein sequence ID" value="AFZ71136"/>
        <property type="gene ID" value="Calag_1429"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1429"/>
    <dbReference type="eggNOG" id="arCOG01551">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_9_1_2"/>
    <dbReference type="OMA" id="KNEYIIV"/>
    <dbReference type="OrthoDB" id="101801at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="1">
        <location>
            <begin position="36"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="175" mass="20180" checksum="EF072207C106986E" modified="2013-03-06" version="1">MVGEVKKLISIQDSLKNVLKDNIINIEQAKGYIDVLVSTEKLVDSAKKLKDFGFDHVKSVTAIDYIAKKQFKVTYHISSYLNEELSKYIIGLSTIINRDNPHLPSLSKIWVSAEFQEREVYEFFGIIFDDHPDLRLLLLTPVIAALKPLRKDFVVKEESDDIEVDYAAYNANKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABC6</accession>
    <name>L0ABC6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroorotate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232253.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0598"/>
    <dbReference type="EnsemblBacteria" id="AFZ70355">
        <property type="protein sequence ID" value="AFZ70355"/>
        <property type="gene ID" value="Calag_0598"/>
    </dbReference>
    <dbReference type="GeneID" id="14211858"/>
    <dbReference type="KEGG" id="clg:Calag_0598"/>
    <dbReference type="eggNOG" id="arCOG00603">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_917034_0_0_2"/>
    <dbReference type="OMA" id="ERIKMGA"/>
    <dbReference type="OrthoDB" id="31316at2157"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="6">
        <location>
            <begin position="46"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="303" mass="33366" checksum="702AC3EA50C4FEA2" modified="2013-03-06" version="1">MSIAESMINLISKSVKYVHPEITMRIGHLIFSIPLPEGKCKHQYEIGSAKVCGKVGIAAGLDKNGKYAKFLSHFNPGFIVIGSTTPKKRIGNKPPRVARILPYSMVNAMGLNNDGLPMVLSRVSKINYPIFISVAGFNLFEIEEQIIYLNKYMSENIQGIEINLSSPTYKGKWKDIIPTLTASKKQIFIKIGPGFSIREYAKIANKEGFGLVLSNTLPIQDNRISVKRGGLSGILLYKLSKAMIKKAREVGGNEIPIIGVGGIMSCKQLNEILQYANAAEIYTAILYMGPGIINSLNERCNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABC8</accession>
    <name>L0ABC8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233058.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1457"/>
    <dbReference type="EnsemblBacteria" id="AFZ71161">
        <property type="protein sequence ID" value="AFZ71161"/>
        <property type="gene ID" value="Calag_1457"/>
    </dbReference>
    <dbReference type="GeneID" id="14212717"/>
    <dbReference type="KEGG" id="clg:Calag_1457"/>
    <dbReference type="eggNOG" id="arCOG01045">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096329_1_0_2"/>
    <dbReference type="OMA" id="DYMIVNE"/>
    <dbReference type="OrthoDB" id="101213at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="196" mass="22299" checksum="E2C44E8F4F6C2FEA" modified="2013-03-06" version="1">MKNLAIAITGMPGSGKSYVSKILSEKLKIKVFSMGDVVREEAKSRGLSLTVENIENLASELRKQYGNNAVAKILMEKLEKNKYNMIIIDGVRGLEELKIFNTIYDICLIAVHASPLTRFKRLNERKREGNDISWDEFTFRDKKNLEYGIGNVIALSDFIVINESNLKDVESQINDIVEVIKNGEWKNYCRGGIETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABF2</accession>
    <name>L0ABF2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1484"/>
    <dbReference type="EnsemblBacteria" id="AFZ71186">
        <property type="protein sequence ID" value="AFZ71186"/>
        <property type="gene ID" value="Calag_1484"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1484"/>
    <dbReference type="eggNOG" id="arCOG00600">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076812_0_0_2"/>
    <dbReference type="OMA" id="GSDWAFN"/>
    <dbReference type="OrthoDB" id="67420at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="56"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="136"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="199"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="276"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="329" mass="36863" checksum="E95493B264469F18" modified="2013-03-06" version="1">MSNSKRMTNIKLSKYVKPITNVSSKYSIGYRYIRADSEPNWSQRVKEKSGDAGLLASKPAITISPNSTILEALEKMSSYNVRGLIISDSRTSLKGIIMATDLVNYLGGGEFYNIIQQRYNKNLFNALQNEKVSNIMNTMPVFVKTTQKLTEIIKLMAINNLGMLPVIDDLNRVVGVITEHDIVKHIIYKDTGKKVSSIMTSNIVSAYENDTLKRAAQLMSLYGFRRIPVISTKENEIIGIVSAKDFVNFFGSHEVFKNVSSYNIEDVLSLQLTLIMKKEINTINENADIGEAATEMINRNTNSLIVINDNNEAVGIITERDLLMSLAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABH0</accession>
    <name>L0ABH0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0738"/>
    <dbReference type="EnsemblBacteria" id="AFZ70482">
        <property type="protein sequence ID" value="AFZ70482"/>
        <property type="gene ID" value="Calag_0738"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0738"/>
    <dbReference type="eggNOG" id="arCOG05989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166553_0_0_2"/>
    <dbReference type="OMA" id="HNISKEC"/>
    <dbReference type="OrthoDB" id="125523at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="127" mass="14455" checksum="E8B555921BF6854D" modified="2013-03-06" version="1">MQRLMTKYVHLLGKESRQKIIEILADERGVRELANELDITPAAVSKYLSGLTHPSDLVIERAIKIANEDEIRKIAKIVEEEFIEGLTSFVEWSVDKGVLDTRFYRRLNDITAKVGLVTLSQRDLNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABM1</accession>
    <name>L0ABM1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232343.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0700"/>
    <dbReference type="EnsemblBacteria" id="AFZ70445">
        <property type="protein sequence ID" value="AFZ70445"/>
        <property type="gene ID" value="Calag_0700"/>
    </dbReference>
    <dbReference type="GeneID" id="14211960"/>
    <dbReference type="KEGG" id="clg:Calag_0700"/>
    <dbReference type="eggNOG" id="arCOG08343">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2730124_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="71" mass="8495" checksum="E5F9EC263776E6A1" modified="2013-03-06" version="1">MDINELKNNILFLLEKNDELTFDEIKKMLNWSGDSRPLRKALSELVRESKVQRVPNYERRRMVFKKGNNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABN8</accession>
    <name>L0ABN8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VWA domain containing CoxE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0715"/>
    <dbReference type="EnsemblBacteria" id="AFZ70460">
        <property type="protein sequence ID" value="AFZ70460"/>
        <property type="gene ID" value="Calag_0715"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0715"/>
    <dbReference type="eggNOG" id="arCOG06080">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_445255_0_0_2"/>
    <dbReference type="OMA" id="CIRIAYR"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="644" mass="74949" checksum="A017582FACD2A09D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABP6</accession>
    <name>L0ABP6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232449.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0811"/>
    <dbReference type="EnsemblBacteria" id="AFZ70552">
        <property type="protein sequence ID" value="AFZ70552"/>
        <property type="gene ID" value="Calag_0811"/>
    </dbReference>
    <dbReference type="GeneID" id="14212071"/>
    <dbReference type="KEGG" id="clg:Calag_0811"/>
    <dbReference type="HOGENOM" id="CLU_2152482_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="111" mass="13150" checksum="1DD63A95D4A5FEEC" modified="2013-03-06" version="1">MEEKIPGKQLNRKIMLKLMNAIQENKPPYSLTRLADYMDVPDSTLEPYFRLLRDNKFATVVLDFSRKIFRIKINICYCKRKVVRFVAAQRLLASGKISYIYRNNIKLLFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABQ6</accession>
    <name>L0ABQ6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232459.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0821"/>
    <dbReference type="EnsemblBacteria" id="AFZ70562">
        <property type="protein sequence ID" value="AFZ70562"/>
        <property type="gene ID" value="Calag_0821"/>
    </dbReference>
    <dbReference type="GeneID" id="14212081"/>
    <dbReference type="KEGG" id="clg:Calag_0821"/>
    <dbReference type="eggNOG" id="arCOG08842">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2419863_0_0_2"/>
    <dbReference type="OMA" id="NMGLAER"/>
    <dbReference type="OrthoDB" id="118947at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="91" mass="10576" checksum="77C8488A189183DE" modified="2013-03-06" version="1">MAEQWLIDSSKIIEKARNLSEVEKKVFKYFLESISVGDLRAIMELEKKGIKDPRSVIENLILMGLIERGNYCYNLPYPLRVYISKQGIPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABS8</accession>
    <name>L0ABS8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0756"/>
    <dbReference type="EnsemblBacteria" id="AFZ70500">
        <property type="protein sequence ID" value="AFZ70500"/>
        <property type="gene ID" value="Calag_0756"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0756"/>
    <dbReference type="eggNOG" id="arCOG03142">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1318475_0_0_2"/>
    <dbReference type="OMA" id="HINKEVI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="208" mass="23396" checksum="75AD1DDF3C40A837" modified="2013-03-06" version="1">MNSTNRIIMCLRGDYKAIKIIKSKKELLEKQGIIIINDYINSETSVIISPLKNTPEYDVYYKNIEHLKNVIYEEDPEVALFKAIVYPKSKFDHVIVGIDPGISCGYVILGDGLIIGEGKVSCNTIGNTIKKELEKIPHINKEVILGSGEGWITAGNSLIKNGLSYKIVREDDVAKNMPKTPIFKIFKDKDVRSAMVIALRGSRNWMDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABU9</accession>
    <name>L0ABU9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative P-loop ATPase/GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232422.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0783"/>
    <dbReference type="EnsemblBacteria" id="AFZ70525">
        <property type="protein sequence ID" value="AFZ70525"/>
        <property type="gene ID" value="Calag_0783"/>
    </dbReference>
    <dbReference type="GeneID" id="14212043"/>
    <dbReference type="KEGG" id="clg:Calag_0783"/>
    <dbReference type="eggNOG" id="arCOG04328">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084678_0_0_2"/>
    <dbReference type="OMA" id="NGWYQYE"/>
    <dbReference type="OrthoDB" id="83136at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="290" mass="32499" checksum="D94E3C56500EF638" modified="2013-03-06" version="1">MKVLVIGLLEENSGKTIFASSIINALISQGYDSVGFKPLGATELWSHPEALIESKKNKMVVTSDSIMLHKFSREKEPINIINPFGGLLIPVLPEKLRNLNSFSNALYMPNMRLGISRLTLCPSNSLYNTHLINVNAIERSSKSVEYELLDLVSVIENIVKVDDEYILNLISGGALRDIDKCLNYLENRHEIVVIESNSNIASPTPLSTNADVVVIVTPGEAMVVDGNRYKKAIELLNLNGKPWVIKTQEVFQLTNYLFSIELPILEDQFSGYNNDTLNYIIEYIKNIIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABZ1</accession>
    <name>L0ABZ1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232529.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0892"/>
    <dbReference type="EnsemblBacteria" id="AFZ70632">
        <property type="protein sequence ID" value="AFZ70632"/>
        <property type="gene ID" value="Calag_0892"/>
    </dbReference>
    <dbReference type="GeneID" id="14212152"/>
    <dbReference type="KEGG" id="clg:Calag_0892"/>
    <dbReference type="eggNOG" id="arCOG02793">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055959_0_0_2"/>
    <dbReference type="OMA" id="PESPEWQ"/>
    <dbReference type="OrthoDB" id="42642at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="405" mass="45747" checksum="1A324FA685B7345A" modified="2013-03-06" version="1">MAEINKIDFGPLNKYQWLIIISSSFSMFIYGLVLALPSISTTWNFVPSNDYVYIFLSIPVGTLIGNIIIGRFADLKGRKNMFILTLLLYGVGSLIVLLSNSFSFLIIGLFVSQIGLGGEMPTLLTYLSEMMPIKYREIVLIFTTNIANIGVLMGGILSLRLGLLSISQERFYYLISLIASIILMLIFRLMIPESLRWKIIETQGKKQIKVEKLWFKIYFLTSLIIATALTYALLALTIGPYIFPNLTSILLIVYNLGESIGGFISLYLVKKIGTRIFTLFSYLGGFITMIFAILDFMLFKSILYIFITLLFINGLFGEFAWAARVSLEPVIFPTGFRSTGIALSRLLPYFLYAASIFYAASFNAMQYLIYNLILWGIGGLASILWYIYGMETTNKKLEEINNELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABZ9</accession>
    <name>L0ABZ9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232539.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0904"/>
    <dbReference type="EnsemblBacteria" id="AFZ70642">
        <property type="protein sequence ID" value="AFZ70642"/>
        <property type="gene ID" value="Calag_0904"/>
    </dbReference>
    <dbReference type="GeneID" id="14212164"/>
    <dbReference type="KEGG" id="clg:Calag_0904"/>
    <dbReference type="eggNOG" id="arCOG00057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_7_0_2"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="7487at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="291"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="460"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="617" mass="68216" checksum="CBE45E2C17BC7724" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC70</accession>
    <name>L0AC70_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232624.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1005"/>
    <dbReference type="EnsemblBacteria" id="AFZ70727">
        <property type="protein sequence ID" value="AFZ70727"/>
        <property type="gene ID" value="Calag_1005"/>
    </dbReference>
    <dbReference type="GeneID" id="14212265"/>
    <dbReference type="KEGG" id="clg:Calag_1005"/>
    <dbReference type="eggNOG" id="arCOG01422">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064028_1_0_2"/>
    <dbReference type="OMA" id="KQFATKE"/>
    <dbReference type="OrthoDB" id="65708at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024271">
        <property type="entry name" value="DUF3782"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012431">
        <property type="entry name" value="PDDEXK_10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12644">
        <property type="entry name" value="DUF3782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07788">
        <property type="entry name" value="PDDEXK_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="239" mass="27248" checksum="F01098310F18FD4D" modified="2013-03-06" version="1">MKSEEIREEIKKVLIDNPSIIAEAIAQRPEIIYEVLAKLTPWQNLATKDDIRDVKNSLSKLDAKVTGLEEKVGNLEKQFATKEDISKLVTKEEAKQFATKEDIKRLENIVNALGARWGILSESSFRNGIYEILKDIGWEIKNELIYDKDGYVYNDPSEVEIDIVIKDGNIIMIEIMSALKRGDLPIIKRKKELYEKKAGVKVSEIIAITPFIHDKYQDKVIAMAKDMGIKIITSLDNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC73</accession>
    <name>L0AC73_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kef-type K+ transport system, membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232527.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0890"/>
    <dbReference type="EnsemblBacteria" id="AFZ70630">
        <property type="protein sequence ID" value="AFZ70630"/>
        <property type="gene ID" value="Calag_0890"/>
    </dbReference>
    <dbReference type="GeneID" id="14212150"/>
    <dbReference type="KEGG" id="clg:Calag_0890"/>
    <dbReference type="eggNOG" id="arCOG01956">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_541436_0_0_2"/>
    <dbReference type="OMA" id="TVRVMMD"/>
    <dbReference type="OrthoDB" id="40122at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="387"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="503" mass="56475" checksum="2F7474577D91AAE7" modified="2013-03-06" version="1">MISNTILSFLYIGLIILISKVLEEALKRFYVPAFVSIIVSGIILGPAVLKFIIPNQSINFLSQLGITFILFLAGVEEFTLDKKPNLRIFVSSLIQVFIPLIFILLLFKILNINEALILAIPLAMTSTGPLARALSEINISKTEIGNTLFYQAIITEIIFIVLFVGFSQKGRILEAFIGTSIVVIAIFALGQLYSKIFAKVMHILKAREIETALIISIILIVGYFSDYYGFNAAISALFLGYLFRDYFKDRPEIIERIRGITYGFFEPIFFADIGLEVVKITPDIVFISLSLIAIIMLTKILSGYLSANIIKLDDKWLNSWAQTAKGGVDTSLLLVSLLSGFINNQQYSFSVLAIAVVAILSPIFLRKYKIVGEEKMNIKLSMPLSSLKNDNYDIVYCDTSLSEVAKIFSKKDISEIIVVNRDKIPIGVFSVKNLIYIDSYNYESTIVCDTYLKPVDALLYNNTIGDAMRKIRDNDLSVIAVIDKEKKLLFPVYRKDLLKLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC90</accession>
    <name>L0AC90_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232547.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0916"/>
    <dbReference type="EnsemblBacteria" id="AFZ70650">
        <property type="protein sequence ID" value="AFZ70650"/>
        <property type="gene ID" value="Calag_0916"/>
    </dbReference>
    <dbReference type="GeneID" id="14212176"/>
    <dbReference type="KEGG" id="clg:Calag_0916"/>
    <dbReference type="eggNOG" id="arCOG05398">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_870453_0_0_2"/>
    <dbReference type="OMA" id="DINFHEG"/>
    <dbReference type="OrthoDB" id="81576at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="319" mass="37752" checksum="34C5BA7541DB218F" modified="2013-03-06" version="1">MKYCLYGTVYNNVNTVEKAIESVYDAIFDQIVITDNFSNDGTYEKLIKMKKDYNLKIYRLKSSRGLGMAYSLKKCPNNSLTAYIHLDVIYNNMLIKIMETELSKVIISNIFQWSYVAKKEEIINKGNWRDLQAAEEMDLISRVGIDYSIPIVIGYNASWKMKDSERRYSNGFFNYVKRKYRIYLDHIRGNGISKNYLKLKIKNDNENKEMLYKLISPVFWNILFKISDLYGKYHNHVIPNDLYVYLNIYKKIIDPKDVGLNNEKFMAYSPKKIYGIDFITYADNEIKKKISNIKCDYINNNVKIYYINNNVKIYYNLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACA3</accession>
    <name>L0ACA3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232659.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1040"/>
    <dbReference type="EnsemblBacteria" id="AFZ70762">
        <property type="protein sequence ID" value="AFZ70762"/>
        <property type="gene ID" value="Calag_1040"/>
    </dbReference>
    <dbReference type="GeneID" id="14212300"/>
    <dbReference type="KEGG" id="clg:Calag_1040"/>
    <dbReference type="eggNOG" id="arCOG00014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_0_2"/>
    <dbReference type="OMA" id="AIVKQGP"/>
    <dbReference type="OrthoDB" id="98664at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="8"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="320" mass="34606" checksum="06FBD662E435ACAD" modified="2013-03-06" version="1">MSDSKTIDITSIGHALMDMRFMVEKFAEPDEEADILEQSTGPGGSAVNVSLNVRKLGGTSAIITKVGLDTFGRSIVEDLMKSKVDISGLKICFGETGFSIVIIDQQGNISIYGFKGCAEKLEPKEIDSETISKSKIIHIASLRPDTSIRAAVVAKENDTLVSWDPGRRLSLRGLKELRGLIKLVDIILLNEQECKNLTGIDNPEKCSQLLKSIGPENVIVKMGPKGLYANTNDFVGYMPAFRVKEVRDSTGSGDAFAAAYLLSLTRGIKTVDALEFAQAVAALKVTKLGANAIPTQEEALEFLKQQKKLVNDEAHTGTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACB2</accession>
    <name>L0ACB2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1050"/>
    <dbReference type="EnsemblBacteria" id="AFZ70772">
        <property type="protein sequence ID" value="AFZ70772"/>
        <property type="gene ID" value="Calag_1050"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1050"/>
    <dbReference type="eggNOG" id="arCOG01531">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092680_0_0_2"/>
    <dbReference type="OMA" id="FERMGAV"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="234" mass="27388" checksum="A872E64297DA2E7C" modified="2013-03-06" version="1">MIHLEKIKKNVIIKIELPEEDYKILSKIAKSKGYTLTNDYIREIIIDAAERKENMQINKESLDQLSRKIEKTVQDLLNPFTQKIDELSSRIADLIESLEEVKEEKEVKEEKPLLKESKEEEKGKKKTAVEILREQGVIFSDDVRWLRNPDAYFKKLESSGALVLYFDNERIALDKEYWNRFKAKLESIAIRDAKEVEELIISEFGENGGKLFNILIKKGLVYYDESLNAWTTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACF3</accession>
    <name>L0ACF3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232714.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1095"/>
    <dbReference type="EnsemblBacteria" id="AFZ70817">
        <property type="protein sequence ID" value="AFZ70817"/>
        <property type="gene ID" value="Calag_1095"/>
    </dbReference>
    <dbReference type="GeneID" id="14212355"/>
    <dbReference type="KEGG" id="clg:Calag_1095"/>
    <dbReference type="eggNOG" id="arCOG04294">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1275387_0_0_2"/>
    <dbReference type="OMA" id="KWGYLIV"/>
    <dbReference type="OrthoDB" id="126058at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="215" mass="24596" checksum="D12DF1F077FF025B" modified="2013-03-06" version="1">MYSLTGIQALDTLINPINKGNIIEIYGDWRIALSISHMTMASLTRYGKVGVVYIQDFGNLDPYFVRKMIKIFGGNFDNIYISRAFRRYDIPELIKSIEGINNLILIDPYLFSPVSPLNYNLLTPITGAIKEISSKGITAIIFNRETSLGKFLPEGGKFHHHILHAIIKVLPYRNGIEAILIKHYAKLTPRISYISYKELGDERLWVGQHLLQEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACJ7</accession>
    <name>L0ACJ7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH:ubiquinone oxidoreductase chain I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1432"/>
    <dbReference type="EnsemblBacteria" id="AFZ71139">
        <property type="protein sequence ID" value="AFZ71139"/>
        <property type="gene ID" value="Calag_1432"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1432"/>
    <dbReference type="eggNOG" id="arCOG01543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_4_5_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ71139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="216" mass="24770" checksum="830C4BE12B347ADB" modified="2013-03-06" version="1">MPAKVALKRNPKKNPLGRVFAGNIGALAVGLKYFFDPNRITLLYPHEYIKLRQGYRGFIVLIQEKCISCSSCARICPARAMKMLSVKVFDKRLKKEMVKKFPVINYNRCIFCGYCVDVCPTEALYHVAYHDLVYMNMQDMILSLEDFQKEPENVSAKEGVPIRYIFDEKRGLVKIKYEEEKKEIAKPQQQVPQQQTSQTTQPNNPQPKQADKGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACP3</accession>
    <name>L0ACP3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nucleic acid-binding protein, contains PIN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232814.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1198"/>
    <dbReference type="EnsemblBacteria" id="AFZ70917">
        <property type="protein sequence ID" value="AFZ70917"/>
        <property type="gene ID" value="Calag_1198"/>
    </dbReference>
    <dbReference type="GeneID" id="14212458"/>
    <dbReference type="KEGG" id="clg:Calag_1198"/>
    <dbReference type="eggNOG" id="arCOG00719">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1076050_0_0_2"/>
    <dbReference type="OMA" id="MATIPFM"/>
    <dbReference type="OrthoDB" id="135122at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="258" mass="29379" checksum="CFD0547050C335E3" modified="2013-03-06" version="1">MVTNIEISGYSENALDALVRAGVYSNKTEAVREAIRRFIDSFDMKEIAFRAYKEGKISFQLAIEISGMGIEEVIWYFLKKNVSPEIGVIDIKELNENIEEIEKRNSLVFDLSSTYTILELDKIDLIKKLDKRLLISKETNNSIRSLIMRYSKLRGSLVYLGNYEVIQVKNPLNEFARKNGITLQEAEAISISKKENAILVSDDIRTRQTAKSKGIVGVPTLSLFLYSKKFNIIDEKQLNEIIAKMGTIPLIIPSELFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACS6</accession>
    <name>L0ACS6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233126.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1530"/>
    <dbReference type="EnsemblBacteria" id="AFZ71229">
        <property type="protein sequence ID" value="AFZ71229"/>
        <property type="gene ID" value="Calag_1530"/>
    </dbReference>
    <dbReference type="GeneID" id="14212791"/>
    <dbReference type="KEGG" id="clg:Calag_1530"/>
    <dbReference type="eggNOG" id="arCOG00504">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_2_4_2"/>
    <dbReference type="OMA" id="FINEDHA"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="14"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="205" mass="23178" checksum="40A7F2E70D18ECA6" modified="2013-03-06" version="1">MKLYDDIEVIDNTNAHVYVIYNKGKVVQVDSGSKGDADKIINYYKTRNIRPDFIFLTHTHVDHIGGLAKVVKEFSPKVFVNKNEADIVKGKAKPEGSWLVRFFSLFVKVEPIEKVYDDLEIEKEFDNVKILHTPGHTPGSTTLIVEKGGKKYAFVGDALFSKDSQLYVNKTFARDYNLALKSAELIKNMKPIIILPGHGKAIEYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACT8</accession>
    <name>L0ACT8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="4">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">surE</name>
        <name evidence="6" type="ordered locus">Calag_1148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="4">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232767.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1148"/>
    <dbReference type="EnsemblBacteria" id="AFZ70870">
        <property type="protein sequence ID" value="AFZ70870"/>
        <property type="gene ID" value="Calag_1148"/>
    </dbReference>
    <dbReference type="GeneID" id="14212408"/>
    <dbReference type="KEGG" id="clg:Calag_1148"/>
    <dbReference type="eggNOG" id="arCOG02303">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_1_2_2"/>
    <dbReference type="OMA" id="INIGPNM"/>
    <dbReference type="OrthoDB" id="110625at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="5">
        <location>
            <begin position="5"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="273" mass="29983" checksum="77648657771441E1" modified="2013-03-06" version="1">MLGSILITNDDGINSPGINYLIEELSKQGFDVYVVAPKNQVSGAGKSHSFYVKVEKCYVKNAKESWCVDGKPADAVAIGLRYLLKDVKPDIIVSGINIGPNMGLMDFFTSGTIGGALEGILLGYKAIAASFAVLRGIKTREQDILLKKAAKITAEISKIMLDIFREEKIDLININFPSIKPIGFKVTKMSWLSNMDVKLDSKDDVYQVMGWKTDNLEEAYAGGEEESDVAMVKKGYISLSPLCVRCIPEAISYVKAFNKIENRIKGIENLILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACU2</accession>
    <name>L0ACU2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fe2+/Zn2+ uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232859.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1245"/>
    <dbReference type="EnsemblBacteria" id="AFZ70962">
        <property type="protein sequence ID" value="AFZ70962"/>
        <property type="gene ID" value="Calag_1245"/>
    </dbReference>
    <dbReference type="GeneID" id="14212505"/>
    <dbReference type="KEGG" id="clg:Calag_1245"/>
    <dbReference type="eggNOG" id="arCOG01868">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_4_4_2"/>
    <dbReference type="OMA" id="TRIEINT"/>
    <dbReference type="OrthoDB" id="109456at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="141" mass="16373" checksum="AFB933E53565A1E1" modified="2013-03-06" version="1">MAETNFDEEMKNVLEKLSEKELRMTPQRILISKTILSMVKNHSSLKEIYDETQKVLPRVGMSTVYNTIKMLEALKIIDTFDVDGKMRIDQTFPHINIYCRNEDKIIDLDENAMEEITKILAKYGVNMNIKKILIDGKCIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACU9</accession>
    <name>L0ACU9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233151.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1556"/>
    <dbReference type="EnsemblBacteria" id="AFZ71254">
        <property type="protein sequence ID" value="AFZ71254"/>
        <property type="gene ID" value="Calag_1556"/>
    </dbReference>
    <dbReference type="GeneID" id="14212818"/>
    <dbReference type="KEGG" id="clg:Calag_1556"/>
    <dbReference type="eggNOG" id="arCOG02726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2340005_0_0_2"/>
    <dbReference type="OMA" id="PLYNVWD"/>
    <dbReference type="OrthoDB" id="143200at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="97" mass="11314" checksum="7E1BAD16111EEE9F" modified="2013-03-06" version="1">MSANCNNMELINKLIELSRLNFTEEEIEKLCQDIEKIRSVLNQVSVLSKLDVKPLYNVWDNILNPPAKIGIEKIDIHELITNERSIDRKVKIPWRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACW4</accession>
    <name>L0ACW4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl18</name>
        <name evidence="6" type="ordered locus">Calag_1174</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232792.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1174"/>
    <dbReference type="EnsemblBacteria" id="AFZ70895">
        <property type="protein sequence ID" value="AFZ70895"/>
        <property type="gene ID" value="Calag_1174"/>
    </dbReference>
    <dbReference type="GeneID" id="14212434"/>
    <dbReference type="KEGG" id="clg:Calag_1174"/>
    <dbReference type="eggNOG" id="arCOG04088">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056222_2_0_2"/>
    <dbReference type="OMA" id="MAHGPRY"/>
    <dbReference type="OrthoDB" id="108717at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_L18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_L5_euk/L18_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="PTHR23410"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="199" mass="22638" checksum="65AD23094EE0CD2C" modified="2013-03-06" version="1">MKGGPRYKLALKRRRQGKTDYRLRYRLVISQKPRAVVRKTNKYILVQIVEFDAKGDKTIVAAHSKELSKLYNWKGYGKNTCAAYLTGYLAGLRAKQKGINEAILDIGLQTPSKGNRIFAALKGLVDAGIQIPHSEEILPDEERVKCEHISKWAEDLKKNNEDAYKRQFSKQLGRLPPEELSRHFEEVLNAIKSKEGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADB5</accession>
    <name>L0ADB5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Proliferating cell nuclear antigen homolog</fullName>
            <shortName evidence="2">PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pcn</name>
        <name evidence="4" type="ordered locus">Calag_1393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232999.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1393"/>
    <dbReference type="EnsemblBacteria" id="AFZ71102">
        <property type="protein sequence ID" value="AFZ71102"/>
        <property type="gene ID" value="Calag_1393"/>
    </dbReference>
    <dbReference type="GeneID" id="14212653"/>
    <dbReference type="KEGG" id="clg:Calag_1393"/>
    <dbReference type="eggNOG" id="arCOG00488">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_1_0_2"/>
    <dbReference type="OMA" id="NASKMKY"/>
    <dbReference type="OrthoDB" id="70433at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PTHR11352:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA_N" evidence="3">
        <location>
            <begin position="6"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ71102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="253" mass="27917" checksum="A13C5A9C6081583D" modified="2013-03-06" version="1">MASLKAVYPSGSKFKKIVQALARVNDEGTFHFSTDGLSSWVFSPDKTILGIFKVSSTGFEELSVDSDISLTVNIGELSKVLRRSTRNDKIILEYTTGNSYMKVSLIDEKTGVERSFEISSGESEGNEIKEIKMNPTVRFILSAGDIDTLIKDAKLVGDIIKITGKEDQIIAEASGEEKFYQWIMKKDSPLQELNIDEESSSSYSLSSLKSTLEPITTIAESVSLEFTSDYPLKIEFSVSGPEEFIIYVAPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADC1</accession>
    <name>L0ADC1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232947.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1341"/>
    <dbReference type="EnsemblBacteria" id="AFZ71050">
        <property type="protein sequence ID" value="AFZ71050"/>
        <property type="gene ID" value="Calag_1341"/>
    </dbReference>
    <dbReference type="GeneID" id="14212601"/>
    <dbReference type="KEGG" id="clg:Calag_1341"/>
    <dbReference type="eggNOG" id="arCOG04130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_929385_0_0_2"/>
    <dbReference type="OMA" id="INIRIHA"/>
    <dbReference type="OrthoDB" id="112466at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007003">
        <property type="entry name" value="DUF655"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40734">
        <property type="entry name" value="PTHR40734"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04919">
        <property type="entry name" value="DUF655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="299" mass="34225" checksum="594CAA8711C87459" modified="2013-03-06" version="1">MGQRAPQRKESEHVAAVEIEAVILDYMETGYYMDPHPWHKEKPVAQAIGVRKFTLLDGIPLGNKVEPLDVVTLARETVKTINEPLDPTGKRFRPFDVSLACIPGADKKIYCTTVNPVSQRISDLIDISLSDPSSSLVYLRSPSDLSKVAKERGLSEKILVVPRTPISYKDISEIAKRNLQEAVRFIIKSNEKLFIEFFNIAEPINIRLHSIELLKGVGKKTLKTLLETRERKKFSSFDEIKKILKVDPIDILSDKILEEITNQPKYYLFVEPKEPNVPYLNYLDTMRRSLYQKQNKAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADQ8</accession>
    <name>L0ADQ8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233072.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1473"/>
    <dbReference type="EnsemblBacteria" id="AFZ71175">
        <property type="protein sequence ID" value="AFZ71175"/>
        <property type="gene ID" value="Calag_1473"/>
    </dbReference>
    <dbReference type="GeneID" id="14212733"/>
    <dbReference type="KEGG" id="clg:Calag_1473"/>
    <dbReference type="eggNOG" id="arCOG05631">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115255_0_0_2"/>
    <dbReference type="OMA" id="TYPDRIC"/>
    <dbReference type="OrthoDB" id="94129at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="206" mass="23220" checksum="32EB42ED7F5D36C5" modified="2013-03-06" version="1">MSASSGKLSIGEEVYLRGLTGRLVGIYLFKGFNKVAILTYPDRICESISSAAAVSYLDSYGYSENKVKIFDYSENIDDIIKSIIDWNPDAIYLAFGGEQRLVNVNDMTIKVLNSLYNHGYKGNILIHVRVWLATKQLSTILSNNELKEYLRSVQGIRLFTADANLRKFMFNYVLISKDGKVTLNKYAETDITQEHADLLKLSLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADT1</accession>
    <name>L0ADT1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ordered locus">Calag_1499</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1499"/>
    <dbReference type="EnsemblBacteria" id="AFZ71200">
        <property type="protein sequence ID" value="AFZ71200"/>
        <property type="gene ID" value="Calag_1499"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1499"/>
    <dbReference type="eggNOG" id="arCOG01762">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_0_2"/>
    <dbReference type="OMA" id="RDLHGTH"/>
    <dbReference type="OrthoDB" id="198at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019969">
        <property type="entry name" value="RNAP_Rpo2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03670">
        <property type="entry name" value="rpoB_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 14 23" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="19">
        <location>
            <begin position="25"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="18">
        <location>
            <begin position="199"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="20">
        <location>
            <begin position="429"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_4" evidence="21">
        <location>
            <begin position="537"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_5" evidence="22">
        <location>
            <begin position="621"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="16">
        <location>
            <begin position="669"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="17">
        <location>
            <begin position="1042"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1148"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AFZ71200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="1172" mass="132357" checksum="CFBFBC9AF5A2B462" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADV5</accession>
    <name>L0ADV5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233127.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1531"/>
    <dbReference type="EnsemblBacteria" id="AFZ71230">
        <property type="protein sequence ID" value="AFZ71230"/>
        <property type="gene ID" value="Calag_1531"/>
    </dbReference>
    <dbReference type="GeneID" id="14212792"/>
    <dbReference type="KEGG" id="clg:Calag_1531"/>
    <dbReference type="eggNOG" id="arCOG04069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017233_1_0_2"/>
    <dbReference type="OMA" id="FIEYRIT"/>
    <dbReference type="OrthoDB" id="58391at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="PTHR12150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="276" mass="31586" checksum="DA74B21001A801EA" modified="2013-03-06" version="1" precursor="true">MSCNEFPPKKRNKKLLVLLPISVLSVEDSLIDKTYKAGFISRILSIYKVDEVILYRDDESNSFDEKFLQLILNYQIIPPHIKKKIIKKSKLLKYAGILPPLRLVNHDPPKKAEIGKILDGYVEKCDENYCIVYLGMIGNGYLDKKEVDDKIITVKIKSIKNKIMLEKASWGNLYTGYKVSKIKNLDIKKFKDEGYLIVGTSKLGECFNDKIKEEIDNKLRNSKGIVFVFGGPHAELYNEKEFDYILNTVLNQGTLTVRTEEALASTLAIFNYISNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-11-13" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>U3GK32</accession>
    <name>U3GK32_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetolactate synthase</fullName>
            <ecNumber evidence="9">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Calag_0153</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="9">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231837.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0153"/>
    <dbReference type="EnsemblBacteria" id="AFZ69939">
        <property type="protein sequence ID" value="AFZ69939"/>
        <property type="gene ID" value="Calag_0153"/>
    </dbReference>
    <dbReference type="GeneID" id="14211413"/>
    <dbReference type="KEGG" id="clg:Calag_0153"/>
    <dbReference type="eggNOG" id="arCOG01998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_2"/>
    <dbReference type="OMA" id="CFGTSGP"/>
    <dbReference type="OrthoDB" id="7134at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="12">
        <location>
            <begin position="3"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="10">
        <location>
            <begin position="197"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="11">
        <location>
            <begin position="390"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ69939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="568" mass="62907" checksum="6BA6CF91619A1FA5" modified="2013-11-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-11-13" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>U3GLC7</accession>
    <name>U3GLC7_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Riboflavin kinase</fullName>
            <ecNumber evidence="5">2.7.1.161</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">CTP-dependent riboflavin kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">CTP:riboflavin 5'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Flavokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">Calag_0492</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>CTP + riboflavin = CDP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.1.161"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal riboflavin kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.161" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232156.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0492"/>
    <dbReference type="EnsemblBacteria" id="AFZ70258">
        <property type="protein sequence ID" value="AFZ70258"/>
        <property type="gene ID" value="Calag_0492"/>
    </dbReference>
    <dbReference type="GeneID" id="14211752"/>
    <dbReference type="KEGG" id="clg:Calag_0492"/>
    <dbReference type="eggNOG" id="arCOG01904">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140165_0_0_2"/>
    <dbReference type="OMA" id="PYEGTLN"/>
    <dbReference type="OrthoDB" id="91297at2157"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039063">
        <property type="entry name" value="RibK_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023602">
        <property type="entry name" value="Riboflavin_kinase_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40706">
        <property type="entry name" value="PTHR40706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01982">
        <property type="entry name" value="CTP-dep_RFKase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP-dep_RFKase" evidence="17">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AFZ70258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="132" mass="15150" checksum="C1D244AB6FFA3C62" modified="2013-11-13" version="1">MCKKTFKAKVFSGKNEGEFFVSLYSKNIKNKLGFIPYPGTLNAKLISDVEEFNQCLLKSKMIIIDPPNIPNTKFGRVYAYPILIFNSLNSYILRPEITIYNKEVIEIISDKKLRDLLNINDGSIIEINILIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7Q7</accession>
    <name>L0A7Q7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231801.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0115"/>
    <dbReference type="TCDB" id="2.A.1.37.5">
        <property type="family name" value="the major facilitator superfamily (mfs)"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ69903">
        <property type="protein sequence ID" value="AFZ69903"/>
        <property type="gene ID" value="Calag_0115"/>
    </dbReference>
    <dbReference type="GeneID" id="14211375"/>
    <dbReference type="KEGG" id="clg:Calag_0115"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_741024_0_0_2"/>
    <dbReference type="OMA" id="LINAAFM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="373" mass="41855" checksum="DB9CDB1121FA22E3" modified="2013-03-06" version="1">MKSKNYLSYLIIFLISLTAQIPLTSMRYVVPYLAHSYGASIFIIGLLGTIYGLIYFILASIFGKLSDKFGIKKMASIGMILYILVIISYKFYDRPYEFLIGRAFEAVSMSMVWPAVESLSSKLGGKSKEEALLMYTFGWSVGASIAPYAVAYLLSYNYIYPLIFSSIISLISALLIISSKQGIEIEINKYEGNFSILFNIFLPMLLYGFDSSIFYSFYSVYGPVFGFNKEDTGLLGTLYGILQTLAFILSWLFAKKISSNKLIIGGTIMSVPLFILYFDHSYIFNSILFSILGLGMGFVYYATLINIFRTFHRDLTSKTGIFESSIGIGYVIGPLIAGIPTKLGYIFPWIILAIFSFIILIIEVYGYIEGKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7R7</accession>
    <name>L0A7R7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231769.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0081"/>
    <dbReference type="EnsemblBacteria" id="AFZ69871">
        <property type="protein sequence ID" value="AFZ69871"/>
        <property type="gene ID" value="Calag_0081"/>
    </dbReference>
    <dbReference type="GeneID" id="14211341"/>
    <dbReference type="KEGG" id="clg:Calag_0081"/>
    <dbReference type="eggNOG" id="arCOG06027">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137928_0_0_2"/>
    <dbReference type="OMA" id="AHPEHWW"/>
    <dbReference type="OrthoDB" id="101098at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="117" mass="14442" checksum="1CDF3A3B1BB9C183" modified="2013-03-06" version="1">MIKLKRVYDKVDEEDGLRILVERLWPRGIKKEEKKIDLWLKEIAPSNELRKWFHHDPNKWEEFKNRYYQELNNKKDIVNKLLEIIKNNKNVTFLYSTKEKNYNNAVALKEYIENYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7S4</accession>
    <name>L0A7S4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231821.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0135"/>
    <dbReference type="EnsemblBacteria" id="AFZ69923">
        <property type="protein sequence ID" value="AFZ69923"/>
        <property type="gene ID" value="Calag_0135"/>
    </dbReference>
    <dbReference type="GeneID" id="14211395"/>
    <dbReference type="KEGG" id="clg:Calag_0135"/>
    <dbReference type="eggNOG" id="arCOG01707">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_2"/>
    <dbReference type="OMA" id="KYDLAEH"/>
    <dbReference type="OrthoDB" id="36092at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="119"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="225"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ69923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="383" mass="42146" checksum="C34FE06A54BF785E" modified="2013-03-06" version="1">METKSDIDLLRSSVREFSEKVLMPVAKKIDAENFISEDILNQVANMGYFALRVPDKYGGPNLSTLESAIVVEELARASGAVAVISGISGTMVAYPLVHYASEELKEEYLGRLSKGKIGAFALSEPCCGSDAANITTKAEIDGNDYVINGRKTWITNSTYADFFLVAARTGKQEDRHKGITIFVVDNKDCIEKSKLDMMGVRGSGTSELLFKDCRVPKENIVGEVNNGFKIIIDGINEGRVVTAAIGLGIMQAAFDESLNYAKIRETMGKPIIEHEMVQSMIADMKVKLEASRLLIYNAAQKIDNNEIDYPMWSSIAKYATAKWGVDVVRLAMQVEGGFGYSKESNVERYYRDIKGIEIGDGTNEIQKLVISRSLAGKITSVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7W3</accession>
    <name>L0A7W3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231861.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0178"/>
    <dbReference type="EnsemblBacteria" id="AFZ69963">
        <property type="protein sequence ID" value="AFZ69963"/>
        <property type="gene ID" value="Calag_0178"/>
    </dbReference>
    <dbReference type="GeneID" id="14211438"/>
    <dbReference type="KEGG" id="clg:Calag_0178"/>
    <dbReference type="eggNOG" id="arCOG00310">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_2"/>
    <dbReference type="OMA" id="CTIEAHE"/>
    <dbReference type="OrthoDB" id="98508at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="4">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="147" mass="16741" checksum="7B550611F7258756" modified="2013-03-06" version="1">MVKVGDKAPVFEGIDDSGNKFSLKDFLGKYNIVVYFYPKDDTPGCTKEACSFRDNWDLLKNLDTIVIGVSSDDIDSHKNFKKKYSLPFILISDKDKKIRKLYGADSFLIPSRITYLINKEGIITLIYKNQLNPQSHVIEVLNKLKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A809</accession>
    <name>L0A809_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="5">3.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + succinate</text>
            <dbReference type="Rhea" id="RHEA:22608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:58087"/>
            <dbReference type="EC" id="3.5.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231864.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0182"/>
    <dbReference type="EnsemblBacteria" id="AFZ69966">
        <property type="protein sequence ID" value="AFZ69966"/>
        <property type="gene ID" value="Calag_0182"/>
    </dbReference>
    <dbReference type="GeneID" id="14211442"/>
    <dbReference type="KEGG" id="clg:Calag_0182"/>
    <dbReference type="eggNOG" id="arCOG01107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_3_2"/>
    <dbReference type="OMA" id="CAHQPGE"/>
    <dbReference type="OrthoDB" id="14646at2157"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010182">
        <property type="entry name" value="ArgE/DapE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01910">
        <property type="entry name" value="DapE-ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="8">
        <location>
            <begin position="197"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ69966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="412" mass="46989" checksum="8B8FBF235717C078" modified="2013-03-06" version="1">MDIDEAIDEIKKDMINFLIKIINIPTENPPGLNYEKFVDYMYDFLISLDYNIKIVEPKEELKELVKYGSGRRPNIIANYGNKGVKIGFNSHYDVVPAGKGWSHDPYNATIEEGKIYGRGSSDMKSGIASQIFAVEALKIMNNIKDKITIRQFIVPDEETVGNKNAGTYYLVEKGFINKENLNYLIFTEPLNPTNIGIGHRGALWGTFNLYGKKSHGGFPQKGLDVIRCASKIINYIYEIADKRSKTISKYPIIPEEAKRPSYLVGTINGGEWMNTVADFLTFSYVRRLIPEETLEFARNEVNEIIKYTENECKGIKIEFLPYYEVDNIMFPVDNGVKIISEKIKEVYNVNPSIVLSPGTFDIRFIYNKGIESFNYGPGLLELAHATDEYVYVEDLIKSTKVISLFLKEFLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A834</accession>
    <name>L0A834_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-hydroxybenzoate polyprenyltransferase-like prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0209"/>
    <dbReference type="EnsemblBacteria" id="AFZ69991">
        <property type="protein sequence ID" value="AFZ69991"/>
        <property type="gene ID" value="Calag_0209"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0209"/>
    <dbReference type="eggNOG" id="arCOG00476">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073311_1_1_2"/>
    <dbReference type="OMA" id="DYFDYEI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="280" mass="30972" checksum="460DF5329B7CB638" modified="2013-03-06" version="1">MIKDYIKIIRPLNDVMIGFSVIVGSFIASGRQLPNLYSLLFGFLTGFFISASSMVFNDIMDIEIDKINNPNRPLPSGKIKIRNAYTMFYLFSIIGLLFSALTGIITFIIAIISYFIAYFYNKFGKKSGFLGNIMVAYSMGVPILYGAAMISKLNFNIMVYWLMIFLSGIAREVTKGIADVEGDRKAGIKTIAVIMGEKKAAIIAFIFYAIAILLSPIPVILGKVYPLIYSIPIAIVDMVFLSVSIITIIKPTKQISTKNKNISLLAMFLGLLGFLISTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A837</accession>
    <name>L0A837_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromatin protein Cren7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231931.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0251"/>
    <dbReference type="EnsemblBacteria" id="AFZ70033">
        <property type="protein sequence ID" value="AFZ70033"/>
        <property type="gene ID" value="Calag_0251"/>
    </dbReference>
    <dbReference type="GeneID" id="14211511"/>
    <dbReference type="KEGG" id="clg:Calag_0251"/>
    <dbReference type="eggNOG" id="arCOG04323">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2177997_0_0_2"/>
    <dbReference type="OrthoDB" id="121222at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="101" mass="11176" checksum="43EDD979E916B872" modified="2013-03-06" version="1">MPRKKVEDPFTCPNCGTKVKEPDKTWTVVSPIPDKYGRVSITIMGSFKCPNCGHSWKAVIKKMKSEGGEGEQLPANNEPGETIEIDLSDLDKVDEDNPPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0A878</accession>
    <name>L0A878_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0293"/>
    <dbReference type="EnsemblBacteria" id="AFZ70073">
        <property type="protein sequence ID" value="AFZ70073"/>
        <property type="gene ID" value="Calag_0293"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0293"/>
    <dbReference type="eggNOG" id="arCOG07264">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1375461_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="198" mass="21772" checksum="D7F10E406C3C4470" modified="2013-03-06" version="1">MSVIIAIVVVAVAISIGAYYYGIYKHGTPTTSLSLYPGYVDPNEIGNIFGGSWNVIGNESGYILINHNNDTITISYVNGTITSNPASSYPNIYSNAFYNYTLLESYTLYSEKSNSSNVIAIEVLETNNNGIPFLKQDIQAVASLYSNNLTYTMGNISYVQVGNSILAIYKNYLILLGSNNNYGNNMLKLLNQTIETFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A883</accession>
    <name>L0A883_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zn-dependent dipeptidase, microsomal dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231976.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0299"/>
    <dbReference type="EnsemblBacteria" id="AFZ70078">
        <property type="protein sequence ID" value="AFZ70078"/>
        <property type="gene ID" value="Calag_0299"/>
    </dbReference>
    <dbReference type="GeneID" id="14211559"/>
    <dbReference type="KEGG" id="clg:Calag_0299"/>
    <dbReference type="eggNOG" id="arCOG04083">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031404_2_1_2"/>
    <dbReference type="OMA" id="DATHLCD"/>
    <dbReference type="OrthoDB" id="37383at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="298" mass="34091" checksum="E0723483459F74BF" modified="2013-03-06" version="1">MRFVDMHEDFGYSVSLGKDLINGNYQSDLTQLKNFDDVMIFSVVFPAMESIFGYSKMYFQSLINQVKIYYRLEKEGMVKIIRNKEDLNKKGIKFLISLEGTDVLNDPYDILLLKELNFKSLGLTWNYDTKFAASCMSKKDYGLTGEGEELVKLANDLGIIIDLAHASKQTVLDVTQITKKPVIVSHTAYRKMKDHPRNVDDEEIEAVIKTGGIIGVMAWYKVLPEKTFESYLKVINELGETFGWDHIGIGTDFLGIEETINGFESISQINKLKEYLGEKADKVLWENAYRVINENLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8G1</accession>
    <name>L0A8G1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0329"/>
    <dbReference type="EnsemblBacteria" id="AFZ70106">
        <property type="protein sequence ID" value="AFZ70106"/>
        <property type="gene ID" value="Calag_0329"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0329"/>
    <dbReference type="eggNOG" id="arCOG00446">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_2_2_2"/>
    <dbReference type="OMA" id="YNGGMVP"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="1">
        <location>
            <begin position="25"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="269" mass="29589" checksum="6E4256C8FB554A65" modified="2013-03-06" version="1">MSTLGDIVVLIKPALNPEMIRSLPDGGVDFDNIPLKLSDIDRNAIEEANRLKEILKGKIYSITISTWGPIAKRDKDIKMAIQEGLAKGVDEAILLEDDAITPGDQVTTASAIVSILNKFNIKPDIILTGEATIDGFSGQVAGRVAAKLDLPYISFARKIDLNGNKVVAERDLEDYVEVVETQLPVVISVTREINSPKPPTLIQIRMASKKPQHVVKISELQNVTMQKKKLIEAKVLAVKRKQTMIEGKSLEEVADKLINILEQEGVLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8I1</accession>
    <name>L0A8I1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNase P/RNase MRP subunit p30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232071.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0403"/>
    <dbReference type="EnsemblBacteria" id="AFZ70173">
        <property type="protein sequence ID" value="AFZ70173"/>
        <property type="gene ID" value="Calag_0403"/>
    </dbReference>
    <dbReference type="GeneID" id="14211663"/>
    <dbReference type="KEGG" id="clg:Calag_0403"/>
    <dbReference type="eggNOG" id="arCOG00307">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1313072_0_0_2"/>
    <dbReference type="OrthoDB" id="144088at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="209" mass="24547" checksum="C7929F12F412005F" modified="2013-03-06" version="1">MKYVDLSINPRNYEEWIKIIPMLKKFNFEIIGMDSNFINDDVLKAAKENSIKVIKRKYFKISNKDELNNILKSSNNSFLVVEPENNYLLNIISQTKTINAIRINLEKNIKINKTIKNLFNINKNGVIEISLKQLLNNDIFLWREMNNLLKNIIKFGLRFYVVSDASNIFELWHPFHVKSLFEILGVDNTYATLSMTTYPYYAISPILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8M6</accession>
    <name>L0A8M6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S6e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps6e</name>
        <name evidence="6" type="ordered locus">Calag_0456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232121.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0456"/>
    <dbReference type="EnsemblBacteria" id="AFZ70223">
        <property type="protein sequence ID" value="AFZ70223"/>
        <property type="gene ID" value="Calag_0456"/>
    </dbReference>
    <dbReference type="GeneID" id="14211716"/>
    <dbReference type="KEGG" id="clg:Calag_0456"/>
    <dbReference type="eggNOG" id="arCOG01946">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1275302_0_0_2"/>
    <dbReference type="OMA" id="FRARAWQ"/>
    <dbReference type="OrthoDB" id="88767at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00512">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_S6e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020924">
        <property type="entry name" value="Ribosomal_S6e_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="PTHR11502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="233" mass="25716" checksum="56A5D16365E49BAD" modified="2013-03-06" version="1">MPAEERPPLRVVISDPKAGDKTVSVKVKGVDDNELKLNESMKKTKEQERKELPKAKVNKKLIEDLKLNEVGVLTLTIKKEGGKSNVPLKTIQDDKVPENEVWVSNELLGEIAGSNEADAIAFRAKAWQLAVPEDIMIRLSGLEIGDEFDGELLGFNNIKLKIKGGSDATGFPMHPGIPGAVRKKVLLSGPPGFHPEKEGERRKKTVRGRMIPDPRAERRKTALAQLNVEISYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8T2</accession>
    <name>L0A8T2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein involved in propionate catabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0490"/>
    <dbReference type="EnsemblBacteria" id="AFZ70256">
        <property type="protein sequence ID" value="AFZ70256"/>
        <property type="gene ID" value="Calag_0490"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0490"/>
    <dbReference type="eggNOG" id="arCOG04285">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026574_3_0_2"/>
    <dbReference type="OMA" id="ECTKHLG"/>
    <dbReference type="OrthoDB" id="26171at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="2">
        <location>
            <begin position="16"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="3">
        <location>
            <begin position="279"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="470" mass="52126" checksum="41BA043D5640423C" modified="2013-03-06" version="1">MIMVRKEMSSYKDLSERIADWASNITYKNIPDNVIEEAKKRILDTFGVAIGAFNEEPVSIARWVAESSSSSRLSATIWGTDRTGPADHVDFANGCASRYFDFMDTYLSKEALHPSDNIPAIIAAAEIAKADGKKILEGLVTAYEITARLADAYSVRSKGWDHVVYIAIASAVGAGKVLGLDKEGLLQAINLSTVNAAALRQTRAGELSMWKGCAAANASRNGLFAAILASRGMKGPSPIFSGEFGFFRVALNGDKFDIPKMGGEDNEPFKVLETSIKYWPVEYHAMSAVDAALKIREKAGSLKPEDIKEVNVKTFQVSYNIIVKDPEKWDPKTRETADHSLPYIVAAALLDGKVWLDTFHEERYLANDVRDVLKKMKVEVDPEHDKLYPTGIKNTITVKLSDGRTFEESSTYPPGHFKNPLSREGVVDKFLRVTNGKLYKRNAKQFIDIVWNIEKCMNISKALSLLKIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8X2</accession>
    <name>L0A8X2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232231.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0575"/>
    <dbReference type="EnsemblBacteria" id="AFZ70333">
        <property type="protein sequence ID" value="AFZ70333"/>
        <property type="gene ID" value="Calag_0575"/>
    </dbReference>
    <dbReference type="GeneID" id="14211835"/>
    <dbReference type="KEGG" id="clg:Calag_0575"/>
    <dbReference type="eggNOG" id="arCOG04062">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152335_0_0_2"/>
    <dbReference type="OMA" id="YGWFVRN"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="141" mass="16225" checksum="0A5E980FA1BEC4B0" modified="2013-03-06" version="1">MGKIKLEVESTKSKTGLHAMRRMVVIIRKDKEEIIKDPIEEGKGTYKEGKSGYVNLNLNPNEYAVHVILVRNPKNKVKGRFIVYDHEGKALLEVKYEKLKIRRSWGDKNLSWIIDRVIELIGLSNYVRHKNYATGQSGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Y1</accession>
    <name>L0A8Y1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232241.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70343">
        <property type="protein sequence ID" value="AFZ70343"/>
        <property type="gene ID" value="Calag_0585"/>
    </dbReference>
    <dbReference type="GeneID" id="14211845"/>
    <dbReference type="KEGG" id="clg:Calag_0585"/>
    <dbReference type="eggNOG" id="arCOG02089">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_591355_0_0_2"/>
    <dbReference type="OMA" id="TITIMNE"/>
    <dbReference type="OrthoDB" id="682at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="455" mass="49461" checksum="5A5E3666104606CA" modified="2013-03-06" version="1" precursor="true">MNKLGKKGSIITILLLISLILVSISFIHVSKAETTPVLKPSFIAYSYWGSNTSPILAYPGASFLPLTITVTYLGPYTLYNVTINSTITYPLILSKGSSIPSLYIPVLTPGTTLKLFGLFNVSNTSNGIYNETLNIKYTIFKTIPETNQTIPISQFTTIKYSVPILGYVDLKLVGFKTNPPVIYAGDTAAILTVYLVNQGNVIASNVSAYLYTPSQLSPLYLGSNKINIGYLPIGTPVNISFPLEIQNITTPISLIEPYKTVQIPASFNTTAILVIKGNGINESFNIPIEVKPSAYFIATQVYHNSLTQGESNTYLTISLINLGSATSKFVTVTLLPNPVITPYVSSSINPLIGVETINYTVGDIPSNAIFNVTFVISASSGITPGTYYIPILVTWYQPPTMTPMHQVIEIPITISSSFSIGSFSKISSIDILYLVAIIVIIILIVMVIIGRRRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Z3</accession>
    <name>L0A8Z3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231792.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0106"/>
    <dbReference type="EnsemblBacteria" id="AFZ69894">
        <property type="protein sequence ID" value="AFZ69894"/>
        <property type="gene ID" value="Calag_0106"/>
    </dbReference>
    <dbReference type="GeneID" id="14211366"/>
    <dbReference type="KEGG" id="clg:Calag_0106"/>
    <dbReference type="eggNOG" id="arCOG01053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_4_1_2"/>
    <dbReference type="OMA" id="WHVIKID"/>
    <dbReference type="OrthoDB" id="73908at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="4">
        <location>
            <begin position="81"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ69894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="255" mass="28118" checksum="DE5CD71004847BF2" modified="2013-03-06" version="1">MGRGHDAQPILNKVPSFVLNPENVYEKIVEKKTLANEFLNDFLKKINNYHGDSSRSVLNILITLYDYWIPKGIGLGISRSIILSKGHASPALYTLLALNKEIDYDELDTFATPNSRLQSHPEGGKIPGILFSTGSLGQGLSIANGIAYAAKLNNENKEIAVILGDGELDEGQIWESISTSYSLKIDNILAIVDRNGFQLSGPTEEIKIKESIKKKFEAFGWYTVEVKNDIKELMIALDLVSEIKGLPRALIVKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0A915</accession>
    <name>L0A915_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232254.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70356">
        <property type="protein sequence ID" value="AFZ70356"/>
        <property type="gene ID" value="Calag_0599"/>
    </dbReference>
    <dbReference type="GeneID" id="14211859"/>
    <dbReference type="KEGG" id="clg:Calag_0599"/>
    <dbReference type="eggNOG" id="arCOG03647">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160445_1_0_2"/>
    <dbReference type="OMA" id="FDDIKWE"/>
    <dbReference type="OrthoDB" id="124033at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="92" mass="10973" checksum="AD42E72A55F1888B" modified="2013-03-06" version="1">MDKDYSDKIRKAIVKYNRYRSPEAVARVIKREGNLVYVKIEGTYCETCGLYDWIEDLKYVFEEYGLISDIIDIKNDEPSFDYRIAVFKIKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A948</accession>
    <name>L0A948_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type branched-chain amino acid transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0636"/>
    <dbReference type="EnsemblBacteria" id="AFZ70391">
        <property type="protein sequence ID" value="AFZ70391"/>
        <property type="gene ID" value="Calag_0636"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0636"/>
    <dbReference type="eggNOG" id="arCOG01274">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_2_0_2"/>
    <dbReference type="OMA" id="FVIIAMQ"/>
    <dbReference type="OrthoDB" id="40722at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="308" mass="34105" checksum="A71F2737C496D3CF" modified="2013-03-06" version="1" precursor="true">MKFEKNYISAILISIIMVVLAFGGPEIYSNKAFFFNLIIITTVALGLNLIYGLTGYLPFGYMLFFGTGAYGVYIGMRIGLVPWEAFAFGFVLNLIIALILLPLFRLKSHYFAIATLAGFEGMYYLIQSPDLSKYTNGALGASLVNIYNPNLTYIISVIFLVFVILLTTFIKSSRFGLSLRAIKDSVISAYLDGVNVPVTRGIAWIISALIASVAGALYGWYSSFFYPETVFALTLGVYIIAFVLFGGLGTILGPIIGTVILYSIYQYFSISYTYYVQLFFGILLIFLILFLPGGLAQVVKKYIKKNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A949</accession>
    <name>L0A949_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231847.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ69949">
        <property type="protein sequence ID" value="AFZ69949"/>
        <property type="gene ID" value="Calag_0163"/>
    </dbReference>
    <dbReference type="GeneID" id="14211423"/>
    <dbReference type="KEGG" id="clg:Calag_0163"/>
    <dbReference type="HOGENOM" id="CLU_1438055_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="188" mass="21883" checksum="952E4CEA9CFEAA35" modified="2013-03-06" version="1">MSEEKLTTNVLILELSTMIVAIALAFNSQSLNYYTISLPAIIDYIIVNVLVIWFWWRYISDRFKYPIKTNNFPLYDVLLLIIISLLPEILRTQDIFYLTGTLAALAFLWALMLRRIIREYANTIDQQSLVSLRHQINIRSSMGLLFLISFAASFISQIIGRLIFILIIFAIIYSVFIDRFSKSNKRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9B9</accession>
    <name>L0A9B9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231917.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0237"/>
    <dbReference type="EnsemblBacteria" id="AFZ70019">
        <property type="protein sequence ID" value="AFZ70019"/>
        <property type="gene ID" value="Calag_0237"/>
    </dbReference>
    <dbReference type="GeneID" id="14211497"/>
    <dbReference type="KEGG" id="clg:Calag_0237"/>
    <dbReference type="eggNOG" id="arCOG04081">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_2"/>
    <dbReference type="OMA" id="YDMGAKM"/>
    <dbReference type="OrthoDB" id="17080at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="PTHR11093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="62"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="449" mass="49615" checksum="02B2C6EA37ACF428" modified="2013-03-06" version="1">MSEIMIGNPKTPRWSSIHSHISGLGLDENGKAKPIADGLVGQVQAREACGLIVELIREGKLGGKGILFAGPSGTGKTALAVAIAKELGEDTPFVSINASEIISAENKTEFMTQAFRRAIGIRMRDVRKIISGVVTEIKYLKKSSPFYPTPILGGAKIKLETKDDSKDVNVGPEIASQFQSLGIRKGDVIMIDEETGEVRRLGRVKEKSTIGFDIDTEKQIEMPSGKIQSTREIVRTFTLHDIDVSIAAQRIAFSIFGFLSEERGIDDQVRKQTDETVRKVTSEGKAQLIPGVLFIDDAHMLDIEAYSFLTKAMESEYAPIIILATNRGITTIRGTDEKAPHGMPRDLLDRLLIILTKPYTEDEIMNIVKIRADELDIPLTDEAVKLLTKIGSERSLRYALQLLDPAKVISAKRNSIKVDVNDIEEASKLFSDVNESTQFLEKYKDLMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9F5</accession>
    <name>L0A9F5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232425.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0786"/>
    <dbReference type="EnsemblBacteria" id="AFZ70528">
        <property type="protein sequence ID" value="AFZ70528"/>
        <property type="gene ID" value="Calag_0786"/>
    </dbReference>
    <dbReference type="GeneID" id="14212046"/>
    <dbReference type="KEGG" id="clg:Calag_0786"/>
    <dbReference type="eggNOG" id="arCOG00755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815347_0_0_2"/>
    <dbReference type="OMA" id="ISASDGM"/>
    <dbReference type="OrthoDB" id="45129at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="340" mass="38099" checksum="FC91B72DDE738D0C" modified="2013-03-06" version="1" precursor="true">MTKVKIIGAGFSGLWTAYLMAKKGYDVVLKETNYPGFGASSKAAGILSFQVPKNMIDISLKSMELYKSLGDDILYWHDSIWLPKDDEFNCALDILNYLSKNDIKTKVIYDDMFDGIYIKKGLIISQPTINIGKALNVLMKNFEIFNGKINDDNEGYYDIIIYANGPWIQDTLNLKGLVKYKCQAHSVEGKQINSIIEDDINEFYYVPESSKRAIIGNGKRIMLSKPEDGFIVDSSEVYNILEKISNEYKEALNMYPVNSWSAPCITTCDGYPVVGEIGKNQYVLSGLNGAGLTLSAGLSDLLINIIEGKVKQPKYLDPLRFKGNCSKILEIFDNICVNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9G6</accession>
    <name>L0A9G6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Selenophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232435.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0797"/>
    <dbReference type="EnsemblBacteria" id="AFZ70538">
        <property type="protein sequence ID" value="AFZ70538"/>
        <property type="gene ID" value="Calag_0797"/>
    </dbReference>
    <dbReference type="GeneID" id="14212057"/>
    <dbReference type="KEGG" id="clg:Calag_0797"/>
    <dbReference type="eggNOG" id="arCOG00643">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574416_0_0_2"/>
    <dbReference type="OMA" id="EFFMVDF"/>
    <dbReference type="OrthoDB" id="19412at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS_C" evidence="1">
        <location>
            <begin position="348"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="475" mass="53433" checksum="E5EC3F7DE1839FA1" modified="2013-03-06" version="1">MNSRRDVLLNNIRQRLSYYRNLGADPLSLATGCAVKVDLLKVVYPAMEKIRPYLLSKNLRIAEREDADIFYADPESVEIKRKVLPLGENVDIDYKFDKEIRAIILIQVYQLSANEPEKFIKKVLPAYESICNCAPLINLGKGHSIVTPFREDEFMLADLISYDKGDKLVAANNDTMHIIDPTSLPSDYRQVSGSLSNSLNDLFVVGAYNNLKIAPVLNAPSDELREELYKNAKRFANEVGAKLLDIEQPKRGRLLLGATVLSSSNKKPPTFHDKADKGMKIITTRPLGELSPITTYLSTAIDESIIDELENKGIDIDQLEKIKEKAVNIISSPNKAMAEVIAKYLPDLNEEFSKEKHIVSATDVTGPGILVVWEQSKLTNTHIKLFDFPLLFPEISEFATENFLMPNATAGTNGGFIIIAPEEIHEDLIKDLKYKGYDPYIIGEIVEKGKQQVDAPKKIKKYILDQEIIDKFNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9H1</accession>
    <name>L0A9H1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232413.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0773"/>
    <dbReference type="EnsemblBacteria" id="AFZ70516">
        <property type="protein sequence ID" value="AFZ70516"/>
        <property type="gene ID" value="Calag_0773"/>
    </dbReference>
    <dbReference type="GeneID" id="14212033"/>
    <dbReference type="KEGG" id="clg:Calag_0773"/>
    <dbReference type="eggNOG" id="arCOG00132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025894_3_1_2"/>
    <dbReference type="OMA" id="LMNIVWP"/>
    <dbReference type="OrthoDB" id="32618at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="400" mass="44033" checksum="151AC812D3C1FC5C" modified="2013-03-06" version="1">MGSEYKKDIYLLGSIRAMRSFSFGYIAFILPLYLRYIGFSVELVGLYSLISTISSSILVLISGYLGDVFSRKKTLIIISMLPIIAYIILISTHNIIIALISSLFGLSLSPMGGGAGGGPVAPLQTAMVASRTNRKERTYIYSYLTITAIIMALLGGIFSSLIINTFPKSYYMILFETAIVLSTISIFLIIPIKETPDKIQKSGNKGFIPRKSAKNISKIAITGLFGSLGLGMILPLLPIYFKDIGATDYIISIIYDFSYLATVFVMIFSGKIERNLGSIKGIFILRTLGSLPLAIIPLIHSLFIASLIYILRTASYQAALPIRQNISMELYSPDERSRGSSITGVARRLPYGVSSLLGSILLQIGAYIFVFSSAALISFLDPLFYYIFFKEIDKNDKVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9I0</accession>
    <name>L0A9I0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232423.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0784"/>
    <dbReference type="EnsemblBacteria" id="AFZ70526">
        <property type="protein sequence ID" value="AFZ70526"/>
        <property type="gene ID" value="Calag_0784"/>
    </dbReference>
    <dbReference type="GeneID" id="14212044"/>
    <dbReference type="KEGG" id="clg:Calag_0784"/>
    <dbReference type="eggNOG" id="arCOG04349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113596_0_0_2"/>
    <dbReference type="OMA" id="HIEGWRS"/>
    <dbReference type="OrthoDB" id="117932at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009324">
        <property type="entry name" value="DUF981"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06168">
        <property type="entry name" value="DUF981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="198" mass="21640" checksum="34C9CC176432494A" modified="2013-03-06" version="1">MALFVDVLDIELMLLGGGLLVLAYWVLLNFTLNYDQQKLSEINRGFGYFFLTLGIYSLAMGLWSSFVWPLPSSYNLVLSDPFSLYGIALIALGFANIYKVPITGVLAGIAILSIPVINYGAAILHFGMTNSPTGAGALYLLIGINGLLSPILQTKAKKYWSYIAILLLVLAAILALYTGIAATYEHIEGWRSWAPFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9J2</accession>
    <name>L0A9J2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231982.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0305"/>
    <dbReference type="EnsemblBacteria" id="AFZ70084">
        <property type="protein sequence ID" value="AFZ70084"/>
        <property type="gene ID" value="Calag_0305"/>
    </dbReference>
    <dbReference type="GeneID" id="14211565"/>
    <dbReference type="KEGG" id="clg:Calag_0305"/>
    <dbReference type="eggNOG" id="arCOG02700">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2613437_0_0_2"/>
    <dbReference type="OrthoDB" id="130932at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="77" mass="8569" checksum="51CBF3D55EB04152" modified="2013-03-06" version="1">MIIQVPNSWDFNKFGYGIVADWYKKEGESVKEGEIICLIMVSKVRVEVKSNQSGKLVKIIANKGTKVKPGDALAEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Q8</accession>
    <name>L0A9Q8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holliday junction resolvase Hjc</fullName>
            <shortName evidence="10">Hjc</shortName>
            <ecNumber evidence="10">3.1.21.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hjc</name>
        <name evidence="11" type="ordered locus">Calag_0883</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Holliday junction resolvase Hjc family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="10"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0883"/>
    <dbReference type="EnsemblBacteria" id="AFZ70623">
        <property type="protein sequence ID" value="AFZ70623"/>
        <property type="gene ID" value="Calag_0883"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0883"/>
    <dbReference type="eggNOG" id="arCOG00919">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139546_1_0_2"/>
    <dbReference type="OMA" id="WYFFHPG"/>
    <dbReference type="OrthoDB" id="97278at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00523">
        <property type="entry name" value="archeal_HJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01490">
        <property type="entry name" value="HJ_Resolv_Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002732">
        <property type="entry name" value="Hjc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014428">
        <property type="entry name" value="Hjc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39651">
        <property type="entry name" value="PTHR39651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01870">
        <property type="entry name" value="Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004985">
        <property type="entry name" value="Hlld_jn_rslvs_ar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="153" mass="17547" checksum="DCC457202BB0DF52" modified="2013-03-06" version="1">MFIIKSVRKLRVKAKATRLENDLANLLWENGFAVVRGPSSGAGVSKRYQPDLIAIKEGKILVIEVKSKSKEGPLYIDSSQILNLLEFAKRANGIPIIAFKLSRKEWRFHLLDKLESTGVNFKLENPSEGLKYRDLEEFMIKKHKEILEFMKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9R1</accession>
    <name>L0A9R1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0375"/>
    <dbReference type="EnsemblBacteria" id="AFZ70149">
        <property type="protein sequence ID" value="AFZ70149"/>
        <property type="gene ID" value="Calag_0375"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0375"/>
    <dbReference type="eggNOG" id="arCOG11441">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2044289_0_0_2"/>
    <dbReference type="OMA" id="PREVIEW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="120" mass="14129" checksum="3BF6C1B4E9733941" modified="2013-03-06" version="1">MSMDNEYIKIESNKATIYGIGKPKIIEVPEEIIPWLTRSKILNRILYILINHESFKKRLSNPMSLRSLLVYLYAKKKNIPTYIMAKRVNIAPEQLYRIERGLKKDNLYNVIMIQIDLDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9R5</accession>
    <name>L0A9R5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromatin protein Cren7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">creN7</name>
        <name evidence="3" type="ordered locus">Calag_0004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="2">Methylated at multiple sites, to varying extents.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Cren7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231698.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ69800">
        <property type="protein sequence ID" value="AFZ69800"/>
        <property type="gene ID" value="Calag_0004"/>
    </dbReference>
    <dbReference type="GeneID" id="14211265"/>
    <dbReference type="KEGG" id="clg:Calag_0004"/>
    <dbReference type="eggNOG" id="arCOG04114">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2911298_0_0_2"/>
    <dbReference type="OMA" id="TPIKVWT"/>
    <dbReference type="OrthoDB" id="122496at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01387">
        <property type="entry name" value="Chromatin_Cren7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038647">
        <property type="entry name" value="Cren7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020906">
        <property type="entry name" value="dsDNA-bd_Cren7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11520">
        <property type="entry name" value="Cren7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="56" mass="6141" checksum="F97A15568CE5EF7F" modified="2013-03-06" version="1">MSSKLPPVKVKDPTTGKEVTLTPIKVWTLAPKKGKGVKIGLFKSPETGKYFRAKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9S9</accession>
    <name>L0A9S9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232545.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0914"/>
    <dbReference type="EnsemblBacteria" id="AFZ70648">
        <property type="protein sequence ID" value="AFZ70648"/>
        <property type="gene ID" value="Calag_0914"/>
    </dbReference>
    <dbReference type="GeneID" id="14212174"/>
    <dbReference type="KEGG" id="clg:Calag_0914"/>
    <dbReference type="eggNOG" id="arCOG01397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055387_2_0_2"/>
    <dbReference type="OrthoDB" id="74894at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="350" mass="42560" checksum="EBD37747EB21E448" modified="2013-03-06" version="1">MSLPYITAIVTAYDRKQYIRQALDSIYRQTLDKDKFEVIVVANYEDINYDKLKYNWIYTKDPRLGTKIVLGSKEAKGEVISLLEDDDYWLKDKLKFVYNKFKEYNLDYLRHQVLITDENLKPLDKNYQPRNSIFFDRIFYSKKINKKLINLMFIVWNNSSINIKKDIIEFISNKLKCLKMYETDKLINISSLIFGNKILFSSKRLSLYRMHNSSSTILKDWSNYYDNNRKNIRYKLLLAIDTLIMYRIVKSYMEQKLKNNWNLESYKNRVYDSYYKYKFRKDNEDFRELKHYAVKQILNNFLKIHDYDFFEYLKVLKIPICDLFSIKSELNINCPYFNNPIYLIKNLIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9X0</accession>
    <name>L0A9X0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0917"/>
    <dbReference type="EnsemblBacteria" id="AFZ70651">
        <property type="protein sequence ID" value="AFZ70651"/>
        <property type="gene ID" value="Calag_0917"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0917"/>
    <dbReference type="eggNOG" id="arCOG01409">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784408_0_0_2"/>
    <dbReference type="OMA" id="RQIYPDC"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="377" mass="44042" checksum="33EAB193F9BE143F" modified="2013-03-06" version="1">MIIMRLKLLVIDDTDLSSFDKGQQYRTYNTYFSLSKYLEINFLLQKLSNPSKLRWANFYVVNDFSRTNSLLYTDYISLFNLNLFNNIMKIIKNINPDLIILEHIYGINRPSLLASKFLGEKIIYNSHGEEIEVCKNSRCKSLIYPVEYSFYKLSDYIFSISYEDAIKACYYYNLPISKFKILPMGIRKIRCNKLNKDLIRNNENSKIIAVFHGNLDYEPNLIAFQKILNISKYFQDIKFIILGNSLKIKPFKSENVEYLGYVEDIDHYLCLSDFAIAPLVEGTGVKTKILDYISARLPIITTRKGIEGINVKDLGNYPIFVYDEVNKDFLTGIQYIMKNIETLKEKAIRANIKLPTWDDVPILMLKYIYEIINVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Z4</accession>
    <name>L0A9Z4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0086"/>
    <dbReference type="EnsemblBacteria" id="AFZ69875">
        <property type="protein sequence ID" value="AFZ69875"/>
        <property type="gene ID" value="Calag_0086"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0086"/>
    <dbReference type="eggNOG" id="arCOG01717">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_7_6_2"/>
    <dbReference type="OMA" id="PAIWTIQ"/>
    <dbReference type="OrthoDB" id="12800at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="393" mass="44130" checksum="5438FECCEB3B6412" modified="2013-03-06" version="1">MEEISVNEALEKSYKFSDYNAVVTINEDAEKEKDKKPILIKDIIYTKGIKTTMGSKVFFNYIPREDARVITLLKRNGYTIVGKTNTHEFASGVTNTSSVFGPSRNPINKELITGGSSGGSAAAVKLKITDVALGTDTAGSIRIPASLCGVIGFRPTHGLISVKGVFPLAPTFDDVGIMSNNVEKLKEVFYILSEKKIKKYDINNLKKVKFALPEGFYSANESIENKFKDFISNLEYEIIDINNLKSAINAFVTIRYSEASWIHEKMRDKFDQYFPDVRRLIEKGFNYYAFEYLNSLKTAKIVRRRLLMILKKYDFIILPTTPIIAPKIEDVIGKEDGEIRSILTSNTWLSSLVGFPSISLPLLNINGYPAGVQLIGKPYEDDKLLEVSKLLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Z7</accession>
    <name>L0A9Z7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0946"/>
    <dbReference type="EnsemblBacteria" id="AFZ70676">
        <property type="protein sequence ID" value="AFZ70676"/>
        <property type="gene ID" value="Calag_0946"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0946"/>
    <dbReference type="eggNOG" id="arCOG01417">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053640_0_0_2"/>
    <dbReference type="OMA" id="MKIFRIA"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="263"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="445" mass="52278" checksum="EE8A6CBB0747A27E" modified="2013-03-06" version="1">MEIFMIGPADINGKLGGSGIHNAEIIIRLPHLGFRVIYSPYPSTLFWALNDEALVDSLRKTLRIMEQNKVIIPSIVFSYLEEKNKILKRLNIESNSFSKAEEFIKEKLKYIHYKNFPQLRDEEIKIMKNIISDVGDVQYIMNLVAEVPSEFIYFAKIFKKRIYNIIHHNPFNWYMALRKTASMFYTNSISNIRNMVGLSLFSPYSSIKYYYDKLISLNLPINFIWINPASYFQFRNSMNLNKNIKNYFIYPANAIDPLALSNESYDKENYFVYAGHLDIFKGLYDMPYILKELKNKIDDYIVFVGHSSNETTKYINKLKKIYPKIKFLGFLKNKEELFKIYSKAKGLIYPTHIDGYSLVILESLGVKTPVITYGIPELVYLYRNIKPVRIVNEFDFKSFANEIIKLSKTDNTRDLFDNTESFIRIHSSWDNVAKQYAKIFKETMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA24</accession>
    <name>L0AA24_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1031"/>
    <dbReference type="EnsemblBacteria" id="AFZ70753">
        <property type="protein sequence ID" value="AFZ70753"/>
        <property type="gene ID" value="Calag_1031"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1031"/>
    <dbReference type="eggNOG" id="arCOG01455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_2"/>
    <dbReference type="OMA" id="AFPHVKP"/>
    <dbReference type="OrthoDB" id="56644at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="6"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="317" mass="34988" checksum="988B0A59CDD8BD8D" modified="2013-03-06" version="1">MKIRAAVLKEFRKPFSIEEINVEPKEDEVIVNIKAVGVCGRDLVVWKGGFRNLKTPLVLGHEIFGEFNGKPVAVFPAKVGKECLKLSEGKENLCNDYSIIGEKEMGGYSEAIAIPKWNLIDLPDKDYEKYAASTCGVATIIHANNLAKLDKGSKVLVTGANGGVGIHAIQYLSNLYEVYAYVRSEEKAKQLKDLNVTPVTSFDFYKKFGKVDGVFEIVGSLTINESMLSLKKEGKLILIGNISGEPINLIRPAFIVMNEISIIGSAAYTKKEYEEAIKIISEGKVKPFYKAYNLSDINNAYNDIINGKIVGRAVLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA57</accession>
    <name>L0AA57_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232685.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1066"/>
    <dbReference type="EnsemblBacteria" id="AFZ70788">
        <property type="protein sequence ID" value="AFZ70788"/>
        <property type="gene ID" value="Calag_1066"/>
    </dbReference>
    <dbReference type="GeneID" id="14212326"/>
    <dbReference type="KEGG" id="clg:Calag_1066"/>
    <dbReference type="eggNOG" id="arCOG08395">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208208_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="62" mass="7241" checksum="F0352BF05053619D" modified="2013-03-06" version="1">MEKYFKEIIIGFFMLLFSFVLTYFGKAYQNLWILVFAMSFSLAGALIGLRGLVEFLTKVFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA67</accession>
    <name>L0AA67_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small nuclear ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232653.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1034"/>
    <dbReference type="EnsemblBacteria" id="AFZ70756">
        <property type="protein sequence ID" value="AFZ70756"/>
        <property type="gene ID" value="Calag_1034"/>
    </dbReference>
    <dbReference type="GeneID" id="14212294"/>
    <dbReference type="KEGG" id="clg:Calag_1034"/>
    <dbReference type="eggNOG" id="arCOG00998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_11_0_2"/>
    <dbReference type="OMA" id="QSDGTMN"/>
    <dbReference type="OrthoDB" id="126995at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="90" mass="9880" checksum="C9FDC6318C2EB28A" modified="2013-03-06" version="1">MSGENKTISPMKYLRDALNAQVYVRLKDGSEFVGILKMTDSTMNLILEDSIEVKDGKQVVAKIGKILIRGSMIQYISFTPEIAAGEAIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA71</accession>
    <name>L0AA71_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate-starvation-inducible E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231920.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0240"/>
    <dbReference type="EnsemblBacteria" id="AFZ70022">
        <property type="protein sequence ID" value="AFZ70022"/>
        <property type="gene ID" value="Calag_0240"/>
    </dbReference>
    <dbReference type="GeneID" id="14211500"/>
    <dbReference type="KEGG" id="clg:Calag_0240"/>
    <dbReference type="eggNOG" id="arCOG13718">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1860606_0_0_2"/>
    <dbReference type="OMA" id="SWIFAGR"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020948">
        <property type="entry name" value="P_starv_induced_PsiE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06146">
        <property type="entry name" value="PsiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="137" mass="15354" checksum="75A1A83E2EEEE613" modified="2013-03-06" version="1">MDRVEYGKKYLELLLVIGEILVAIIISITVIIASFQTFVMLGSMVKVSIPNKSTILELIDTAILLLLALDLLRTVIIGIMEKEIPIKNIIEAAMIVIVREMIVNTLENSSPIYLIYLSLSFVMVSVSMIFIMKYSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA74</accession>
    <name>L0AA74_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein containing a von Willebrand factor type A (VWA) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232222.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0565"/>
    <dbReference type="EnsemblBacteria" id="AFZ70324">
        <property type="protein sequence ID" value="AFZ70324"/>
        <property type="gene ID" value="Calag_0565"/>
    </dbReference>
    <dbReference type="GeneID" id="14211825"/>
    <dbReference type="KEGG" id="clg:Calag_0565"/>
    <dbReference type="eggNOG" id="arCOG00442">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_598029_0_0_2"/>
    <dbReference type="OMA" id="MTQKITW"/>
    <dbReference type="OrthoDB" id="13269at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="279"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="446" mass="49962" checksum="04CB9E6D85F52263" modified="2013-03-06" version="1">MEENQNKKIKQSVYKEIGNIDELRFYRGEKILNIAKELSGKNLDPRISPYLGIDLFYTYYFPIPNIEEFSPEDDEEDAFRRTVISTLLKTESSWKTKIYTSADSVTSTVAAASFIEKLNKLLPQNEGKNNGKEGANQNESDNEGDTSQELQNAIQKASESAMKDAEMAKEVKMLAEKMGAGRGSIFSLESSAEEILKLARETDVAKILERIEGLKLITNAKTKNAINYSKGWISGIEIGGDIERVHYSQLAFPSILFYAEFANDRLLLYEKNLPSNKGPIYVLLDKSGSMVGSKIDWARAVTVALFKKAMDEGRNFFVRFFDSVPYQAMNLKSNANPSEILNVLSYLARVKAGGGTDITRAISSAVDDMEKTKTSSKDKPSDIVLITDGEDRLSPEIINKLLKKSNSRLHSVMIQGHNAFLQQVSYRYLSVKKLEQKEALEVADFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAA2</accession>
    <name>L0AAA2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATPase component of ABC-type sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232693.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1074"/>
    <dbReference type="EnsemblBacteria" id="AFZ70796">
        <property type="protein sequence ID" value="AFZ70796"/>
        <property type="gene ID" value="Calag_1074"/>
    </dbReference>
    <dbReference type="GeneID" id="14212334"/>
    <dbReference type="KEGG" id="clg:Calag_1074"/>
    <dbReference type="eggNOG" id="arCOG00177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OMA" id="MADRMMI"/>
    <dbReference type="OrthoDB" id="88924at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="311" mass="35124" checksum="8AE52E493BA599E4" modified="2013-03-06" version="1">MSVSIKSLEKSYSKTKILKGIDLEIDKGEFFVLLGFSGSGKTTLLRCIAGLEKVDSGKIIIDGVDVTNLEPSKRGVSMVFQNYVLYPHKTVYENLLLPVEDKKDAKKKIEEISKALGIHELLDRMPSQLSGGQQQRVALARALIKNPRVLLMDEPLSNLDAPQRISARRFIKELQRKENITTIYVTHDQIEAMALADRIAVMKDGKILQIGKPEEIYNDPINEFVGSFIGDPPMSIINGNFMKIDKKIGIRADDVVIGDGELEGEVVDVEFINGKYLVHIKFNGSELRGYYYKRINEGEKIKFEIKKYRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAB1</accession>
    <name>L0AAB1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA/RNA helicase, superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231955.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0277"/>
    <dbReference type="EnsemblBacteria" id="AFZ70057">
        <property type="protein sequence ID" value="AFZ70057"/>
        <property type="gene ID" value="Calag_0277"/>
    </dbReference>
    <dbReference type="GeneID" id="14211537"/>
    <dbReference type="KEGG" id="clg:Calag_0277"/>
    <dbReference type="eggNOG" id="arCOG00874">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008213_6_0_2"/>
    <dbReference type="OMA" id="PAITHQT"/>
    <dbReference type="OrthoDB" id="14047at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040699">
        <property type="entry name" value="XPB_DRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18458">
        <property type="entry name" value="XPB_DRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="77"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="314"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="442" mass="51459" checksum="6549010BD8A91156" modified="2013-03-06" version="1">MVTLNYYKGLIVSDTYNPQMRYDERIKKYVALAYKYKEINDYYKDSGINIKDHVLQPLPFPIINDKIKLRTYQEKALESWLKTKRGIIVLPTGSGKTHVALKAISHLKQSTLIMVPTIDLLDQWYKSIVKELGTTPGRIGGGYDDINGITISTYDSAYSRIDSLGNKFSFLIFDEVHHLPSEGYMEIAQLTPAPYRLGLTATPEREDGRHVMLLDLVGPIVYRINTETLSGKYLSEYDIERIYVNLKPDEELKYKEMRSKMKDILNRLNIELRDLNDFKRFLYYASRNKQAREALHLWYESNNIAINSNSKIEKLKELLKEYKEDKIIIFTRDTNMAYRISKEFLIPVVTYKTPKDERKEILDNFRNNKYKVIVASNIFDEGVDIPDANLAIIVGGYGTRRQFIQRLGRILRMKEGKRAKLVEIVTKGTSDYSLSLRRRKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAE6</accession>
    <name>L0AAE6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Probable cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cobD</name>
        <name evidence="13" type="ordered locus">Calag_1124</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 12">Cell membrane</location>
            <topology evidence="3 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the CobD/CbiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232743.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1124"/>
    <dbReference type="EnsemblBacteria" id="AFZ70846">
        <property type="protein sequence ID" value="AFZ70846"/>
        <property type="gene ID" value="Calag_1124"/>
    </dbReference>
    <dbReference type="GeneID" id="14212384"/>
    <dbReference type="KEGG" id="clg:Calag_1124"/>
    <dbReference type="eggNOG" id="arCOG04274">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054212_0_2_2"/>
    <dbReference type="OMA" id="NSGYTMA"/>
    <dbReference type="OrthoDB" id="101304at2157"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ70846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="316" mass="36164" checksum="63529F2D027B739A" modified="2013-03-06" version="1">MIYLPKFLYPNPLYIIASLILALILDIVYPYHKGVFYKIHPVHTSYILSQKLYKPYSSKLRGFFIWIITIGTHLLIYLLLLYLLYRINFILWIIASSYIIKTSLSFKLLYDIVKKVKESLYNNDIEKARNIVSGLVRRDTSNLDEYHISSASIESLSESFVDGILSPLFWLIIFGPIGSLMQRLINTLDGSLGFKDELHKDVGFVSALADTIINYIPARISVIIFALSSVLIGNDLRSLFSCWKKYKNKTESKNAGHPMSSFAGALKISLEKINSYRLCDYDLPKKENINNALKLILVSYIITLILTIAIIYLIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAF0</accession>
    <name>L0AAF0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232748.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1129"/>
    <dbReference type="EnsemblBacteria" id="AFZ70851">
        <property type="protein sequence ID" value="AFZ70851"/>
        <property type="gene ID" value="Calag_1129"/>
    </dbReference>
    <dbReference type="GeneID" id="14212389"/>
    <dbReference type="KEGG" id="clg:Calag_1129"/>
    <dbReference type="eggNOG" id="arCOG00009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_16_0_2"/>
    <dbReference type="OMA" id="PCTATIV"/>
    <dbReference type="OrthoDB" id="15038at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="593" mass="65191" checksum="72D479024A2D2A7F" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAG0</accession>
    <name>L0AAG0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231985.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0308"/>
    <dbReference type="EnsemblBacteria" id="AFZ70087">
        <property type="protein sequence ID" value="AFZ70087"/>
        <property type="gene ID" value="Calag_0308"/>
    </dbReference>
    <dbReference type="GeneID" id="14211568"/>
    <dbReference type="KEGG" id="clg:Calag_0308"/>
    <dbReference type="eggNOG" id="arCOG01706">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_2_1_2"/>
    <dbReference type="OMA" id="CIAKAIR"/>
    <dbReference type="OrthoDB" id="74660at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="2-oxoacid_dh" evidence="2">
        <location>
            <begin position="11"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="237" mass="26628" checksum="44FAE1B75BC0C8A5" modified="2013-03-06" version="1">MEKNNSLPIKEIIEFDPIRQTIAERMMSSLQNSAQLTLMREAKVNGLVKFRESLQDSEYKPTYTEILVKIVAKLLTNEENKLLNSFIEDNKIKVVSTVNLGVAVATNYGLVVPVIKNANNKDLVQIVKELRELSNKAKNMQLTLEDIEGGTFTLTNLGMFGIDSFTPIINPPQTGILGVGRIYKRPEFDENNNVIPSYLTWLSLTFDHRVLDGASAAIFLKELSEILDDDKKIQAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAH8</accession>
    <name>L0AAH8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_1165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232783.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1165"/>
    <dbReference type="EnsemblBacteria" id="AFZ70886">
        <property type="protein sequence ID" value="AFZ70886"/>
        <property type="gene ID" value="Calag_1165"/>
    </dbReference>
    <dbReference type="GeneID" id="14212425"/>
    <dbReference type="KEGG" id="clg:Calag_1165"/>
    <dbReference type="eggNOG" id="arCOG01707">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_805611_0_0_2"/>
    <dbReference type="OMA" id="QEERIWI"/>
    <dbReference type="OrthoDB" id="36092at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="90"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="188"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="346" mass="37717" checksum="9F006FA1557C1EC9" modified="2013-03-06" version="1">MSELPKDIENFLLNEVPKIAKQVDEKNEVPKEFLEKMKGVGLFNLRKNGLGGIYKAVRLASRSSPAIAHVIMISGSGSLKSGIDNSIFSVTITEPGGGTDIKGNLKTVAEEDSEGNAIINGEKVFGSNALYADYFIILAQGPQGPTLYLAERQDNIKIKPMDLISFRGAGISNVIYENTKAKRISQPGKGLREALELINYGRLGYGSIALGIAEGALEEAGKNALSKKIFNKELSEYQSIKWMYAEIEIKIKLLESLIDNAVKKYEKNNLLDPLDAAISKVSSGELAQRATWIGIQLLGGRGFTAGTLLERLNRDARVLDIGEGAREVLLDFIGDQAIKQYKQALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAL3</accession>
    <name>L0AAL3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ordered locus">Calag_1202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232818.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1202"/>
    <dbReference type="EnsemblBacteria" id="AFZ70921">
        <property type="protein sequence ID" value="AFZ70921"/>
        <property type="gene ID" value="Calag_1202"/>
    </dbReference>
    <dbReference type="GeneID" id="14212462"/>
    <dbReference type="KEGG" id="clg:Calag_1202"/>
    <dbReference type="eggNOG" id="arCOG00858">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079546_0_0_2"/>
    <dbReference type="OMA" id="MGGTHPG"/>
    <dbReference type="OrthoDB" id="48934at2157"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_A">
        <property type="entry name" value="PyrH_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011818">
        <property type="entry name" value="Uridylate_kinase_arch/spir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02076">
        <property type="entry name" value="pyrH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="7"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="114"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="226" mass="25054" checksum="97EE93489FEFD84B" modified="2013-03-06" version="1">MEKIVIKISGSLLYPPDKKYYEKTREVIGKIINKGYRIGIVVGGGPLARSYINSLRELNIQESILDILGIESARLNALSLSSALQPYSIPKVPKDLTEAIEIFSNNLIPILGGLQPGHSTNAVSMVLAESLNANVVINMLNNIDGIYDKNPNDPRSKKLDKITYKEMEELIKNMNQIAGGYELLDHVAFELIKRSKIKVIFINGKDPENLLKVINGEKIGTELIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAM3</accession>
    <name>L0AAM3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70931">
        <property type="protein sequence ID" value="AFZ70931"/>
        <property type="gene ID" value="Calag_1212"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1212"/>
    <dbReference type="eggNOG" id="arCOG05938">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1850528_0_0_2"/>
    <dbReference type="OMA" id="EARAYYN"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="138" mass="15953" checksum="27741ADB5881D9CA" modified="2013-03-06" version="1">MLKMSENGEEANEEEEVEESSSQEESQQLIEYKVESPELLDIMLKSFDILEKAAANVIKVNEARAYYNEEVEKKMSELSTSSIKKTRKAKKSKKGKKEEKSKKKTAEKKKESVKESKKKERKAKRGKKEEKSEETNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAM9</accession>
    <name>L0AAM9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232838.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70941">
        <property type="protein sequence ID" value="AFZ70941"/>
        <property type="gene ID" value="Calag_1222"/>
    </dbReference>
    <dbReference type="GeneID" id="14212482"/>
    <dbReference type="KEGG" id="clg:Calag_1222"/>
    <dbReference type="eggNOG" id="arCOG10276">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059141_0_0_2"/>
    <dbReference type="OMA" id="IAYMFHA"/>
    <dbReference type="OrthoDB" id="117498at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="392" mass="43812" checksum="1B170F13A6AF643B" modified="2013-03-06" version="1">MSKETWFAISMVFIALLSSLDIGIYSYIGYRTNVTPFQYGLISALWSLVFIVSNFALGKISNNGNNKLLIAVSFISILATGVLFEFHTLVSLALAYMFHALGVASSNLAISITIFELKSSDKWNYYIELQKFSFYFIRGLGLLSFYFIQGVPFDYFIYFTIMIGFITFLSLPRINLSIERSLHSFTKNLDSISSHIKIFSYLAYDNVGSFPNAIKNGYVSHRRISIKRISMSLFFATLTGDYIFAILPLLVKSDLSLNLLWLSYGITGLLIGISLILLSLFGTTSNKRIAFLSILLRGIWLVTAISFINNLLDLIAYITISSILFSIIDIILYNLFSEGSSGYSSHIYYNSRELGTLTGSLLVGIAFSLGKEIFITIPIISTILSLIMVVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAN1</accession>
    <name>L0AAN1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6 9">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="1 6 9">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pgk</name>
        <name evidence="10" type="ordered locus">Calag_0740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="1 6 9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0740"/>
    <dbReference type="EnsemblBacteria" id="AFZ70484">
        <property type="protein sequence ID" value="AFZ70484"/>
        <property type="gene ID" value="Calag_0740"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0740"/>
    <dbReference type="eggNOG" id="arCOG00496">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_2"/>
    <dbReference type="OMA" id="YVNDAYS"/>
    <dbReference type="OrthoDB" id="46017at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6 7">
        <location>
            <begin position="31"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 7">
        <location>
            <begin position="69"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <begin position="359"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="415" mass="45818" checksum="40435B8E98CBBD94" modified="2013-03-06" version="1">MSGVVISYNERNIATIEDVDLTNKKVLLRVDMNSPIKDNVIMDTSRIRSHIKTIKELVELGSKVVIMSHQGRPGESDFISLKSHTEILSKLLGFNVEFVGDIIGPEARKRIATLEVGEVLVLENTRFLSEENIEMPFEQLMNTNFVKKLSHLFNYYVGDAFASAHRSQASIAGFPLVMPAVAGRVMEDEIKGLSKAINGERPSTLFIGGAKLKDAIKIMNHLIKTKKIDNILTGGLVALLLLKAKGYNIGKAEKIIEEKFASLIPEAKELLKYDNIFLPEDFVSDVDGNVEVVSSKEIKGSPKDIGPQTIDYYNELLKNSKTIILRGPAGVIEDERFRNGTIKLATESLNSNAYVIFGGGHFISILNDLPPMLRKRIGYISTGGGAVVYFLSGEPMPGIEALALSYEKFFKGLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAN6</accession>
    <name>L0AAN6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mn2+/Fe2-transporter, NRAMP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0745"/>
    <dbReference type="EnsemblBacteria" id="AFZ70489">
        <property type="protein sequence ID" value="AFZ70489"/>
        <property type="gene ID" value="Calag_0745"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0745"/>
    <dbReference type="eggNOG" id="arCOG04531">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020088_6_0_2"/>
    <dbReference type="OMA" id="IATFVNS"/>
    <dbReference type="OrthoDB" id="98443at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="398" mass="44385" checksum="F50A3B3072F19CD4" modified="2013-03-06" version="1">MEYKELLKTFGPAWIVMIADVDVASIIEGLQSGIAWGYRMIFIMLILTIPLFFIQDAAGTLGTISGMGLGEAIRKKFGKKQAIIASIPMTITDFLEYVVEYAGIGIGLQLLGIPLIIGLIIIFIFHIAVATSKRYRHAEMFLIPISFILVVATIWIATMFPINSKELLFYGLNPIQPYNNKNYNFLLAASIGAVIMPWMLFFHSGADSRKKIKTENLKYERLETFIGALVSEILMVITVIVGYNLAKIDPNINSDGIINPYTFEKILTSFNTNLLYLLGIGFIASGFLALVVISMASAWGALEALNINKHKWYIIIYSLESLPAILIVLISKNLIYLMLELMVIYTIIVAPPLYYLGRLISDEKIMKGKPIKGVRLKVYWVLSAMVVIGGFIGFISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAQ4</accession>
    <name>L0AAQ4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1249"/>
    <dbReference type="EnsemblBacteria" id="AFZ70966">
        <property type="protein sequence ID" value="AFZ70966"/>
        <property type="gene ID" value="Calag_1249"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1249"/>
    <dbReference type="eggNOG" id="arCOG01137">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_5_1_2"/>
    <dbReference type="OMA" id="IVHFSEF"/>
    <dbReference type="OrthoDB" id="127597at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="140" mass="16385" checksum="4C7CC9B079C436B5" modified="2013-03-06" version="1">MKPIFTLKYRVYWSETDAAIMMHFSNFFRVCERTEEEFFASLNISQKGEIGKRLLMPRVHAECDYKNPLRPGDLYSVNITEILLGKSSIRYTYEIYNESSNQLSAICKIVSVIYDEINNKSMEIPQEIRKKLIEVGAKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAW6</accession>
    <name>L0AAW6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Proliferating cell nuclear antigen homolog</fullName>
            <shortName evidence="3">PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcn</name>
        <name evidence="8" type="ordered locus">Calag_0394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0394"/>
    <dbReference type="EnsemblBacteria" id="AFZ70165">
        <property type="protein sequence ID" value="AFZ70165"/>
        <property type="gene ID" value="Calag_0394"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0394"/>
    <dbReference type="eggNOG" id="arCOG00488">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_1_0_2"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="OrthoDB" id="70433at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PTHR11352:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PCNA_C" evidence="7">
        <location>
            <begin position="129"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="250" mass="28515" checksum="1EA9A51A5AE4F1DE" modified="2013-03-06" version="1">MKIVKIKFKEPRTWRYIIGSIEKIIDEGVFTINEEGLHFRALDTSRIVMIDFIYPKSSFEEFDVDKEENIGVSFSTLSDILKRAEKDDELEMISDENSITLKYIGKGERLFKIPQISLSQDKLPEPKITFTVKAKLTNNTFIDIINDIEAIGESITIRADDNENKLIITGKGDIESAEIELSLEKQNLIELSIDSPDSSTYSIEYLSDMLMAAKEADLITLMYSQDAPAKIDMEYQNGGRITFYISPRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAX1</accession>
    <name>L0AAX1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232461.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0823"/>
    <dbReference type="EnsemblBacteria" id="AFZ70564">
        <property type="protein sequence ID" value="AFZ70564"/>
        <property type="gene ID" value="Calag_0823"/>
    </dbReference>
    <dbReference type="GeneID" id="14212083"/>
    <dbReference type="KEGG" id="clg:Calag_0823"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705185_0_0_2"/>
    <dbReference type="OMA" id="YFYMASF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="390" mass="42783" checksum="DE166FEE8CBBED1F" modified="2013-03-06" version="1">MDNKRRALIYTSLGHFLNDSFIIVFSILIAYYLDMKISASYLGVMGALINILSGLISMWVGIIADRRGVHAKLMLLGYALIGLSIILYAISFLYIKYDLIFIAIASIFLGTGLSFYHPLGGSILQHTFDPRDSPRALGINGSFGSIGRALFPVILVFTINYLGGPLALSIIGIYTFIIGFIVFYGLNPIKIEYKINKDSTNKVSLSSYYYVLIPLAIVIFIRAMFISGVQTYVPTYLSHLLNSKEIMSIILTVSYATAIFGQPYFGKLTGDIGGRKVVFLTTILATLFYIGFLLIKIKIIMALMFVLFSLFAFSGFPVLLGYVGQIVDRNVSAQANSLIWGIGNTIGGAIGILIGGLLLNKIGFYNDMLIFAIIAVISTALLPLIPSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAX4</accession>
    <name>L0AAX4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein involved in formate dehydrogenase formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232928.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1320"/>
    <dbReference type="EnsemblBacteria" id="AFZ71031">
        <property type="protein sequence ID" value="AFZ71031"/>
        <property type="gene ID" value="Calag_1320"/>
    </dbReference>
    <dbReference type="GeneID" id="14212580"/>
    <dbReference type="KEGG" id="clg:Calag_1320"/>
    <dbReference type="eggNOG" id="arCOG05634">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1163757_0_0_2"/>
    <dbReference type="OMA" id="CKSSWRI"/>
    <dbReference type="OrthoDB" id="95915at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024064">
        <property type="entry name" value="FdhE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006452">
        <property type="entry name" value="Formate_DH_accessory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37689">
        <property type="entry name" value="PTHR37689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04216">
        <property type="entry name" value="FdhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144020">
        <property type="entry name" value="SSF144020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="238" mass="26757" checksum="528387E43620AE0D" modified="2013-03-06" version="1">MNNIEEFVSSIRRYGHLAGFKIDIEIARKIEEIQLNIINDINKMISNLQYDDLNSFVSSLSQQGTLQELIKETSKSLGEEIEKKDADNALKEALEGNMDFKGAKTSLIVLQALSRLYAEKFEEKNGNISNQSPYCPVCGSESKTMIKTNNEYKMVCHFCGYTWKVSDKKIVCPYCGNDEEFSLGIFSDKEGRIGLVFCQKCKSSWRIILDESIKAPSIVLPLIALGGEKFKGALPKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB06</accession>
    <name>L0AB06_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232215.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70317">
        <property type="protein sequence ID" value="AFZ70317"/>
        <property type="gene ID" value="Calag_0557"/>
    </dbReference>
    <dbReference type="GeneID" id="14211817"/>
    <dbReference type="KEGG" id="clg:Calag_0557"/>
    <dbReference type="eggNOG" id="arCOG13722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2911299_0_0_2"/>
    <dbReference type="OMA" id="MVYIRLE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="61" mass="7137" checksum="9728913273A3540D" modified="2013-03-06" version="1">MNDLEKKDTRELLDMVYIRLELLEKDVSEMAKSEGSRGKLIAINELTEEIRDILNIIRTKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB16</accession>
    <name>L0AB16_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232491.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70594">
        <property type="protein sequence ID" value="AFZ70594"/>
        <property type="gene ID" value="Calag_0853"/>
    </dbReference>
    <dbReference type="GeneID" id="14212113"/>
    <dbReference type="KEGG" id="clg:Calag_0853"/>
    <dbReference type="eggNOG" id="arCOG00144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_3_2"/>
    <dbReference type="OMA" id="FKIHTFS"/>
    <dbReference type="OrthoDB" id="42639at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="492" mass="53521" checksum="6EE4256A99A4C4B9" modified="2013-03-06" version="1">MEYKWKALSVTSVGSFMSAIDSTVVLLALVPITEDLHADYVTIVWIVIGYLLASTSLVLSLGRMGDMYGRKRIYNLGFVVFTIGSLFAALSMNGIQLVIFRAIEGIGSAMMIANSLAIISIAFPPNERGKAFGVNSIVWATGNILGIVLGGFIITFTTWRWIFLINVPIGIFGTLWAWKTLKETKANNIKESFDVPAAIAFTLGILLIQLGVTNGLLYGWHDISTIISFILSPFPFIFFLVWETRFAKDPIIDLKLFFGNRMFSASTFTATIQSLALFAVNFLLLFYLEGIYGLNVLTASYLIIPMALVNAIIGPFGGRLSDKYGSRLISTIGLGFQAIAILMLSFMNSSTPLWYIALTEAIFGIGGGLFWPSNTSAVMSGAPKGKYGAASGVLSTFRNTGMILSFAVALSAVAARLPSYIVYQLFVGTINSKLDVSTANIYLSAQSFAYHISFGLLIVAMIVSLIRPSKQLQGISSQEKLSQQQKIPLQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB37</accession>
    <name>L0AB37_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_1395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.22" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233000.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1395"/>
    <dbReference type="EnsemblBacteria" id="AFZ71103">
        <property type="protein sequence ID" value="AFZ71103"/>
        <property type="gene ID" value="Calag_1395"/>
    </dbReference>
    <dbReference type="GeneID" id="14212655"/>
    <dbReference type="KEGG" id="clg:Calag_1395"/>
    <dbReference type="eggNOG" id="arCOG00407">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_2"/>
    <dbReference type="OMA" id="DNMDLAE"/>
    <dbReference type="OrthoDB" id="24864at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="6">
        <location>
            <begin position="136"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ71103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="436" mass="50796" checksum="C7A3F264830169D0" modified="2013-03-06" version="1">MSEQNSEFKSTKEIMKLNEGEKAKVRGWVYRKRDLADNIFIVIRDSDGILQTVLPRKNSSEKIVSLAEKVNIESSIIVEGIIKDDERAPGGKELQIENLSVIGFSDDFPIKGGESIDYLLDIRHLWLRSRKLTAIMKIRQSILEGMREYFKRNNWWEVNPPILTQSAVEGGATLFEVNFFGKKAYLSQSAQFYLEVMIFSLERVWAITPSFRAEKSRTRRHLYEYYHLEGEAAWMDMKDMMKHVEGLVKSAIKKVLDERLEELEIVKRNVGILENSLKTSFPEITYDEAIEKLKRKGINLKWGDDIGADEEKVLTEYYDTPFFLTMFPKHLKSFYMKIDDSRPELVYGFDLEAPEGYGEVVGGSQREDSYEKLYKRIIEEGLNPNDYQWYLDLRKYGSVPHSGYGLGVDRLVTWIAGLDHIRDSIPFPRFRERIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB58</accession>
    <name>L0AB58_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232183.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70285">
        <property type="protein sequence ID" value="AFZ70285"/>
        <property type="gene ID" value="Calag_0522"/>
    </dbReference>
    <dbReference type="GeneID" id="14211782"/>
    <dbReference type="KEGG" id="clg:Calag_0522"/>
    <dbReference type="eggNOG" id="arCOG05713">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_671964_0_0_2"/>
    <dbReference type="OMA" id="ECKYSDR"/>
    <dbReference type="OrthoDB" id="78024at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="420" mass="49972" checksum="1EEFD329BDC16CCC" modified="2013-03-06" version="1">MIINKQRSNYKKRMSKELIRKVGKYYIRYQKKLNIVKIYEKLIGENPVNIDKYSLLYLQSSIANLIIRDLISIAEKARKEKITYRELKVEYDKDIFGEISIDHTMNSLPQGLFAYYTYREGLNAPEYSILGYIIRKSRKIASYYYEQMRSIQDPSIQEIKYFDFINEFKDNLSKIKRVSKYFPKGYYRDEIYTDPEWLKRAFMSYRLLKSLNVIKVSAEMLKDSSKENLRKVLYMTESKLYELYLLYIVIKYLESKGKIIKRVNDDGIIELDDLKIYFNKSLQSSNLKMVDNFSESKIEKFKGRPDISLLQSISSLNEKHIIIECKYSMSPSYITAGRFKIMAYSYEYNPLTAVLAIPGLSKKNIYDEEDRGTLEMYEKAKEEGYVEFSYGNYNSFIVIINPLHDDRKNIKRMHFLDNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB79</accession>
    <name>L0AB79_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233013.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1409"/>
    <dbReference type="EnsemblBacteria" id="AFZ71116">
        <property type="protein sequence ID" value="AFZ71116"/>
        <property type="gene ID" value="Calag_1409"/>
    </dbReference>
    <dbReference type="GeneID" id="14212669"/>
    <dbReference type="KEGG" id="clg:Calag_1409"/>
    <dbReference type="eggNOG" id="arCOG13713">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2490256_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="86" mass="10200" checksum="085407250B6FC16C" modified="2013-03-06" version="1">MSEDKGSKIDQNKINELYHINWDSTSDPNYVKKELVNAFRAKAKRVIIHVYNSPDYSYMEKLRNFLGEFLSQTIIIVRENKDNSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB91</accession>
    <name>L0AB91_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233023.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1419"/>
    <dbReference type="EnsemblBacteria" id="AFZ71126">
        <property type="protein sequence ID" value="AFZ71126"/>
        <property type="gene ID" value="Calag_1419"/>
    </dbReference>
    <dbReference type="GeneID" id="14212679"/>
    <dbReference type="KEGG" id="clg:Calag_1419"/>
    <dbReference type="eggNOG" id="arCOG01727">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_5_0_2"/>
    <dbReference type="OMA" id="WLIAESI"/>
    <dbReference type="OrthoDB" id="55053at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="308" mass="34476" checksum="52481CE61107C4B2" modified="2013-03-06" version="1">MDKEQSYEDIDTSILEKWEKVREYLEPKIEDAAKSMENLGIDGIARYLTIGGKMFRGFLTVLFAESLGASLDYASDAAVAIEMVHAASLAIDDIVDKDTNRRGKLSGWIIYGIGKTALTALLLVPVAQRVIEKYGFDAIRYSIKSWEAMVRGEILDAYASLKLNPSEYMNVIKLKTASLFSLSAVLGVIAAKNNNLVDNAEFYGDKLGIAYQLADDIGDYYSYLIGKKEKLDPGEVLFEKYIMHRYPISERGDEIIKNGMNILNDVVNEASNAIVELPESKQKSMLSRIPYFMVNKMLESVGLTLKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABC5</accession>
    <name>L0ABC5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233095.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1496"/>
    <dbReference type="EnsemblBacteria" id="AFZ71198">
        <property type="protein sequence ID" value="AFZ71198"/>
        <property type="gene ID" value="Calag_1496"/>
    </dbReference>
    <dbReference type="GeneID" id="14212756"/>
    <dbReference type="KEGG" id="clg:Calag_1496"/>
    <dbReference type="eggNOG" id="arCOG02113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1691461_0_0_2"/>
    <dbReference type="OMA" id="GANDRRM"/>
    <dbReference type="OrthoDB" id="113827at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012440">
        <property type="entry name" value="DUF1641"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07849">
        <property type="entry name" value="DUF1641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="146" mass="15453" checksum="113EF3755344B045" modified="2013-03-06" version="1">MAENNVEEVSPEVQAQTIAQLLNSIAALKKSGLLGLLNYLAEKSDDTFLTVADDPVLMRLAGLLASLGRGIEKVDGTQYAKAKMTMEDLTNCAFNALGNIDVTKERKLGLFGLMRALGDPDVSQGLGILIDLAKGLGACAKSKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABF4</accession>
    <name>L0ABF4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233125.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1529"/>
    <dbReference type="EnsemblBacteria" id="AFZ71228">
        <property type="protein sequence ID" value="AFZ71228"/>
        <property type="gene ID" value="Calag_1529"/>
    </dbReference>
    <dbReference type="GeneID" id="14212790"/>
    <dbReference type="KEGG" id="clg:Calag_1529"/>
    <dbReference type="eggNOG" id="arCOG01773">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_14_1_2"/>
    <dbReference type="OMA" id="CIVPRES"/>
    <dbReference type="OrthoDB" id="56960at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="41"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="209" mass="24143" checksum="C3AD086B04A27053" modified="2013-03-06" version="1">MVSDPFDTYSLKYDEWYEKHKILYENELNAVFRVKTKGISLEIGVGSGRFAKPLNIDFGLDPSIELLKIARKRGIEVIKGVGEHLPFSNKKFDVIYLIVTICFVDDPIRTLKESNRVLKNNGSIIIGFVPKESKWGKYYESIKDTSPFYKYATFYSYKEIVNMINETDFKVVETISTLFQNVNQKEIYEEPINGYNSDAGFIIIKAMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABG0</accession>
    <name>L0ABG0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232370.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0727"/>
    <dbReference type="EnsemblBacteria" id="AFZ70472">
        <property type="protein sequence ID" value="AFZ70472"/>
        <property type="gene ID" value="Calag_0727"/>
    </dbReference>
    <dbReference type="GeneID" id="14211987"/>
    <dbReference type="KEGG" id="clg:Calag_0727"/>
    <dbReference type="HOGENOM" id="CLU_2152481_0_0_2"/>
    <dbReference type="OMA" id="VTWFEES"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="111" mass="12944" checksum="DE64A5B0EBEB9602" modified="2013-03-06" version="1">MSKSEISKLAETVTWFEESLKKLNNESKELSSSIVQLADSLGKQIRQESKNLLDESVKKLEEAYKESVKKLEEAYKEKEREEIEKSEKLGKENYDQAVKEVFEEIKKIVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABG4</accession>
    <name>L0ABG4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA(1-methyladenosine) methyltransferase-like methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233135.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1540"/>
    <dbReference type="EnsemblBacteria" id="AFZ71238">
        <property type="protein sequence ID" value="AFZ71238"/>
        <property type="gene ID" value="Calag_1540"/>
    </dbReference>
    <dbReference type="GeneID" id="14212802"/>
    <dbReference type="KEGG" id="clg:Calag_1540"/>
    <dbReference type="eggNOG" id="arCOG00978">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025402_0_1_2"/>
    <dbReference type="OMA" id="VVYPKDA"/>
    <dbReference type="OrthoDB" id="64860at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="260" mass="29561" checksum="866EAAAA86EDF8DA" modified="2013-03-06" version="1">MPISEGQNVLVIADNNLGKRKLYLFKVSSKQSYSTFLGNIQGKDILDRNFGESIQLGKGRIYLIEPNLYDIIMYELKRKSQVIYPKDSGYIVSISGIRNGMKVLEAGIGSGFLTIEISRHICPNGKLYAYEIRQDMIEIAKKNLEKTNFTNCVIINNQDVREGVNEKDFDAAFLDMADPWNALNKIHDSLKISSPVIVFVPTVNQIEKLLSNVDINKYVIQEISELIKREWEPRKEAIRPTIRAIGHTGFIILLRTLKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABH8</accession>
    <name>L0ABH8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0654"/>
    <dbReference type="EnsemblBacteria" id="AFZ70405">
        <property type="protein sequence ID" value="AFZ70405"/>
        <property type="gene ID" value="Calag_0654"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0654"/>
    <dbReference type="eggNOG" id="arCOG01879">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1280846_0_0_2"/>
    <dbReference type="OMA" id="YNRKIIH"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="235" mass="27222" checksum="2D3AA7529AF351D7" modified="2013-03-06" version="1">MNDMLLITYSEMIHDTLIAVIMMLWVIFVTIYLARLTYNIAIKRGWSDHSAKYFSRKVIHILAGGLVAFLLPFTFKEPIYPLIMALLISILTYYLHKTGKLMYWFQDPENEYEVHFALMWGIVIFLTWFIDKSFWLGVIPALMMSWGDGITGIIRNIRYKRRVKGWEGSLGMLVVSVIVGLRFGLAGIIAAVFATLVERWNKIDDNITVPLVSLFTLLIFVEFFPSVTKLFMIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABJ8</accession>
    <name>L0ABJ8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233170.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1575"/>
    <dbReference type="EnsemblBacteria" id="AFZ71273">
        <property type="protein sequence ID" value="AFZ71273"/>
        <property type="gene ID" value="Calag_1575"/>
    </dbReference>
    <dbReference type="GeneID" id="14212837"/>
    <dbReference type="KEGG" id="clg:Calag_1575"/>
    <dbReference type="HOGENOM" id="CLU_2313636_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="99" mass="10736" checksum="731EAD2182E81317" modified="2013-03-06" version="1">MISDVLLYSFLLVGILIGVSINLSKKANRKVVKTLNLLTTISVLDLIFFMAITAGDYISRYLTGNEGISLIYSIVLYSIIPGFLGVIIASIIMGGRHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABJ9</accession>
    <name>L0ABJ9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sortase-like acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232696.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1077"/>
    <dbReference type="EnsemblBacteria" id="AFZ70799">
        <property type="protein sequence ID" value="AFZ70799"/>
        <property type="gene ID" value="Calag_1077"/>
    </dbReference>
    <dbReference type="GeneID" id="14212337"/>
    <dbReference type="KEGG" id="clg:Calag_1077"/>
    <dbReference type="eggNOG" id="arCOG00845">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1232701_0_0_2"/>
    <dbReference type="OMA" id="VMASERN"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="221" mass="26167" checksum="7BC65BD5682996A4" modified="2013-03-06" version="1">MFEPIRFELVKREDKDKINKLTENTWEWGDYTPELFEKWVNEGLFIKAISNEEIVGIIHARIFDDFAWFEGVRVKQEIRRKGIGKALAKKAMEMSGKSVFRLAANEKNVPSIQLAKALGFKEIDRFYYVEGKDYNYEKIVEEFNLKETNYDLKYVKGFVNDWVWYPIEKYNGKIYANNDLILLETDPPFLVKGYIEGIRHMSRNFVSNSEGFIVFELNKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABK7</accession>
    <name>L0ABK7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233143.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1548"/>
    <dbReference type="EnsemblBacteria" id="AFZ71246">
        <property type="protein sequence ID" value="AFZ71246"/>
        <property type="gene ID" value="Calag_1548"/>
    </dbReference>
    <dbReference type="GeneID" id="14212810"/>
    <dbReference type="KEGG" id="clg:Calag_1548"/>
    <dbReference type="eggNOG" id="arCOG03661">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003442_1_0_2"/>
    <dbReference type="OMA" id="GQYWDAW"/>
    <dbReference type="OrthoDB" id="20900at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="489"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="973" mass="113179" checksum="AB9DF55103442231" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABS7</accession>
    <name>L0ABS7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitric oxide reductase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0841"/>
    <dbReference type="EnsemblBacteria" id="AFZ70582">
        <property type="protein sequence ID" value="AFZ70582"/>
        <property type="gene ID" value="Calag_0841"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0841"/>
    <dbReference type="eggNOG" id="arCOG04703">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021582_0_0_2"/>
    <dbReference type="OMA" id="VTRTWHT"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="639"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="699"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="2">
        <location>
            <begin position="184"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="730" mass="81957" checksum="3A48CFBFC6CF3621" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABW2</accession>
    <name>L0ABW2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0862"/>
    <dbReference type="EnsemblBacteria" id="AFZ70602">
        <property type="protein sequence ID" value="AFZ70602"/>
        <property type="gene ID" value="Calag_0862"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0862"/>
    <dbReference type="eggNOG" id="arCOG04068">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190408_0_0_2"/>
    <dbReference type="OMA" id="FRIKRGG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="87" mass="9716" checksum="19941DBDE375F3DD" modified="2013-03-06" version="1">MLIVNGDTMDIITFVQQITERITALAWALFLLTWSVGWTIRGSPIPINKLKRLGSSLIEDSIWAAFWLAIGSSLFSFIVYVVNLITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC23</accession>
    <name>L0AC23_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="4">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232569.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0941"/>
    <dbReference type="EnsemblBacteria" id="AFZ70672">
        <property type="protein sequence ID" value="AFZ70672"/>
        <property type="gene ID" value="Calag_0941"/>
    </dbReference>
    <dbReference type="GeneID" id="14212201"/>
    <dbReference type="KEGG" id="clg:Calag_0941"/>
    <dbReference type="eggNOG" id="arCOG04188">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090940_1_1_2"/>
    <dbReference type="OMA" id="RGVFLEW"/>
    <dbReference type="OrthoDB" id="96034at2157"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="185" mass="21704" checksum="EAFC8D6536FF640D" modified="2013-03-06" version="1">MPFEFIKTSVDNVYIIRPKVFEDNRGYFMETFEKRSFSNLDFNVIQENQSYSRKGVLRGLHFQKGKFAQAKIVRVIKGEIFDVAVDIRPDSKTFKKYVSAILSDKNKEMLYIPRGFAHGFEVLSDEAIVVYLVDNFYSPENEGGIIWNDKDINIDWPIKEPILSKKDSSWPTLKQFLENERSEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC32</accession>
    <name>L0AC32_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0954</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232579.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0954"/>
    <dbReference type="EnsemblBacteria" id="AFZ70682">
        <property type="protein sequence ID" value="AFZ70682"/>
        <property type="gene ID" value="Calag_0954"/>
    </dbReference>
    <dbReference type="GeneID" id="14212214"/>
    <dbReference type="KEGG" id="clg:Calag_0954"/>
    <dbReference type="eggNOG" id="arCOG01029">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_2_1_2"/>
    <dbReference type="OMA" id="NTHQDYK"/>
    <dbReference type="OrthoDB" id="65810at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="8">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="93"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="7">
        <location>
            <begin position="250"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="354" mass="40410" checksum="9A430520B4FFFCA0" modified="2013-03-06" version="1">MPKVFSPGRVNIIGEHTDYSFGYVMPMAINLGNYFEYIPYNKIKIRSDAYNEEIELDLSEVNKKQNKWIDYVLGIYNALYKINLKPGGINGRIYGNLPISSGLSSSASIELAIITALNYTYKLNLDKIQMALIGKKAENEFVGVPSGILDQFAIEFGKRGYTIFLDTENLFYEYIPFPMDISIIVYNTGVKRELAKTEYTERKRIVEESLKYLNKKSSKEITEKELEKLNSLYKKRMGYIIRENRRVLIARDALKENNLDLLGKILVESHKDIAENYEVSSKELDFIVNRAVKYGALGARLTGAGFGGSAIILAYKDKAEIIANNIHSEYIREFKYNSFYNIVESNDGSMVVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC68</accession>
    <name>L0AC68_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-type polysaccharide/polyol phosphate export systems, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0885"/>
    <dbReference type="EnsemblBacteria" id="AFZ70625">
        <property type="protein sequence ID" value="AFZ70625"/>
        <property type="gene ID" value="Calag_0885"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0885"/>
    <dbReference type="eggNOG" id="arCOG01467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_3_2"/>
    <dbReference type="OMA" id="LHQRERF"/>
    <dbReference type="OrthoDB" id="77595at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="3"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="277" mass="31050" checksum="F646D6A325C68455" modified="2013-03-06" version="1">MQEVYTLTIRELKKWLSRRGTFIVSLITPLFWLGLFGKSLNFASMFTPTNIPPQYSSLLSQYVNQQLLNLFGTTNYFTYLASGMLVVFGFFQSVFGGTNLVFEKRLGYLNRLLMTPTPRSGIFLSKVFGTLVRIMFYEVVLLLIAYGLGFRFYSGINALNIILAGIAIILIAIGFVSIFAAIAFNVDNVEIMFAIVNLINLPLMFASSALFPLKQMPSWLREIAKFNPITYAADIVRHNLIGTPISNYLISWVILIVISAALFIIGMIASINAMERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC83</accession>
    <name>L0AC83_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="6" type="ordered locus">Calag_1330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232936.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1330"/>
    <dbReference type="EnsemblBacteria" id="AFZ71039">
        <property type="protein sequence ID" value="AFZ71039"/>
        <property type="gene ID" value="Calag_1330"/>
    </dbReference>
    <dbReference type="GeneID" id="14212590"/>
    <dbReference type="KEGG" id="clg:Calag_1330"/>
    <dbReference type="eggNOG" id="arCOG01704">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_0_3_2"/>
    <dbReference type="OMA" id="LDMIVAN"/>
    <dbReference type="OrthoDB" id="56027at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="5">
        <location>
            <begin position="197"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="202"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="414" mass="45992" checksum="836FFF1008034ADC" modified="2013-03-06" version="1">MDIEESKFHPSSAIIKSYSDNLYDKCIILAVTASISLYRSLDTARWLLRRGAKVKVIMTEEASNLISPDMFYWATGNKPIVKLTGATEHVALAKECDSMLIAPATFSTMSKIAYGITDNPVSLTVITAMGYNKPIVLVPAMHEKMENTIQYEEIEKRLKQSNIFIISPYVAEEVAKYPDPQFVARVTASHTLRGYDMKGLRILITAGATRSWIDDVRFITNPSSGRMGIELSIESYSRGATVDLVYGHTEVQVPHTVNSYHVDTTNEMANKISELTSKYDYDIIIGAAAPVDFNVEKYEGKMKSELNYQINLVPAKKALKSISKRPKVLISFAAESIKNDQELIEKAREKIAKYNSDIVVANPANLSGIGFSSLYDRAILIFNNGKIIDVEKTLKENLARIILDSALSLIKGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACB7</accession>
    <name>L0ACB7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232577.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0952"/>
    <dbReference type="EnsemblBacteria" id="AFZ70680">
        <property type="protein sequence ID" value="AFZ70680"/>
        <property type="gene ID" value="Calag_0952"/>
    </dbReference>
    <dbReference type="GeneID" id="14212212"/>
    <dbReference type="KEGG" id="clg:Calag_0952"/>
    <dbReference type="eggNOG" id="arCOG00150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_491464_0_0_2"/>
    <dbReference type="OMA" id="NWLWINP"/>
    <dbReference type="OrthoDB" id="16335at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="550" mass="60631" checksum="2C6C04650F125800" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-12-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACD9</accession>
    <name>L0ACD9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1080"/>
    <dbReference type="EnsemblBacteria" id="AFZ70802">
        <property type="protein sequence ID" value="AFZ70802"/>
        <property type="gene ID" value="Calag_1080"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1080"/>
    <dbReference type="HOGENOM" id="CLU_263796_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1248"/>
            <end position="1269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="1272" mass="135058" checksum="59AD9607373EA6F3" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACE1</accession>
    <name>L0ACE1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0987"/>
    <dbReference type="EnsemblBacteria" id="AFZ70710">
        <property type="protein sequence ID" value="AFZ70710"/>
        <property type="gene ID" value="Calag_0987"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0987"/>
    <dbReference type="eggNOG" id="arCOG04164">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069296_0_0_2"/>
    <dbReference type="OMA" id="LTYAWDR"/>
    <dbReference type="OrthoDB" id="58679at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010581">
        <property type="entry name" value="DUF1152"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06626">
        <property type="entry name" value="DUF1152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="371" mass="41085" checksum="F82094727E66B8FF" modified="2013-03-06" version="1">MKIKKERLKNFKNKINMVYKMDEKIEGRTYKSLESAVKGKNVFVFGAGGGGDIVGAYYISNKVKRFGGNPLVGSVVWERFSVDPYPGPIPLEMMVNVDPIGFSSALVNSDSYALRYGMEIEPQITKFVKLIGEKAVFIDLTKGTEGVIRALYDISQNFDIDLIIGVDVGGDILALGCEENLWSPLADSISLSALYNINMDSLLAVYGPGGDGELETNTILKYISDIAKENGLIEILGMNMEEAEILDNLVKHVNTEASLIPLISFKGEYGNKMIRNNTRNVMLSPILSTSYILNVDIVYKRSELPKLVKNTGGIGQANQALNNHCIYTELDLENDLMKLRGESSNNPINLIELRDQGIRNLIKRNCNPIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACI0</accession>
    <name>L0ACI0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_1130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232749.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1130"/>
    <dbReference type="EnsemblBacteria" id="AFZ70852">
        <property type="protein sequence ID" value="AFZ70852"/>
        <property type="gene ID" value="Calag_1130"/>
    </dbReference>
    <dbReference type="GeneID" id="14212390"/>
    <dbReference type="KEGG" id="clg:Calag_1130"/>
    <dbReference type="eggNOG" id="arCOG01707">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_2"/>
    <dbReference type="OMA" id="VHRWAQE"/>
    <dbReference type="OrthoDB" id="36092at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="133"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="242"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="399" mass="44887" checksum="D067696F1DBEA57E" modified="2013-03-06" version="1">MVFPFKSIEDFKIDINNEHELFRKSVREFLEKNVEPRWKEIEDTNQIPPEIFKAMGEQGFFGIGIPEEYGGQGGGQLMTTIMMEEIARIVPSLAVAVGVNHLFGVPILKFGSEELKKKYIMPIARGEAQGAHANTEPSGGSDVAGIQSRAEKQNDHYVINGRKVFISGAEKADYFIVSARTNPQQQNKRWWGITVFVVEKNWPGVKLGQHFKVIGMRGEQPYEVIFDNVKVPQENVVGKVDEGFKVIVSTYDYTRIGIAAQAVGIAQATFEKALNYSLQRELFGQQIINFEMIDEKIAEMYMKLEAARLLTYWAASLADANRSEFIIAASLAKSFASEAAEWISRQAVQIHGGYGVDQEMGLERYLRDSVITTIYEGTNEIQRLTIARELVRQAFGLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACI9</accession>
    <name>L0ACI9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233026.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1422"/>
    <dbReference type="EnsemblBacteria" id="AFZ71129">
        <property type="protein sequence ID" value="AFZ71129"/>
        <property type="gene ID" value="Calag_1422"/>
    </dbReference>
    <dbReference type="GeneID" id="14212682"/>
    <dbReference type="KEGG" id="clg:Calag_1422"/>
    <dbReference type="eggNOG" id="arCOG03882">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1187735_0_0_2"/>
    <dbReference type="OMA" id="THPAGHC"/>
    <dbReference type="OrthoDB" id="141187at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="233" mass="27177" checksum="C822E522280144F8" modified="2013-03-06" version="1">MNKKYQETRITNGSLILSIINKIILKIEDTYDDNYNLFDAKIDYKIKDIDYLLKKLKDNVIDLKINTPWDFKDHIEEINDKKIIIKNDTNLKNYISIKDLYDFIPYIPFHTDLSIINSFTQKTTSSNIEYLFLYDYNGYLSILEGETLKVKIPFIKVAYNMHSHPNGHCGFSLPDINSGLDLLSEGGLASSVVTERCALVMYRQGLVIEDDYINIKSRKYENLKSIKFIKIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACJ0</accession>
    <name>L0ACJ0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Translation initiation factor 5A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Hypusine-containing protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">eIF-5A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">eif5a</name>
        <name evidence="13" type="ordered locus">Calag_1140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Functions by promoting the formation of the first peptide bond.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1140"/>
    <dbReference type="EnsemblBacteria" id="AFZ70862">
        <property type="protein sequence ID" value="AFZ70862"/>
        <property type="gene ID" value="Calag_1140"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1140"/>
    <dbReference type="eggNOG" id="arCOG04277">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102600_3_0_2"/>
    <dbReference type="OMA" id="QIMDMET"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00085">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022847">
        <property type="entry name" value="Transl_elong_IF5A_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="Transl_elong_IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="PTHR11673"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 11 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF-5a" evidence="12">
        <location>
            <begin position="75"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="modified residue" description="Hypusine" evidence="11">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ70862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="139" mass="15471" checksum="527F9F7B5A07AA1B" modified="2013-03-06" version="1">MKYGEKMSVQFATLGDLKKGSYIVIDNEPCRVVEITKAKTGKHGSAKAHVVAVSLFTGQKKTLIAPTDTQVQVPIIEKRNGQVLADLGNNLQVMDMESYDTIEVEKPNDEPELLEKLKPGVEVEYWLIMGKAKIVRIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACK0</accession>
    <name>L0ACK0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH:ubiquinone oxidoreductase subunit 2 (Chain N)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233041.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1437"/>
    <dbReference type="EnsemblBacteria" id="AFZ71144">
        <property type="protein sequence ID" value="AFZ71144"/>
        <property type="gene ID" value="Calag_1437"/>
    </dbReference>
    <dbReference type="GeneID" id="14212697"/>
    <dbReference type="KEGG" id="clg:Calag_1437"/>
    <dbReference type="eggNOG" id="arCOG01540">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_1_4_2"/>
    <dbReference type="OMA" id="FYIRVIV"/>
    <dbReference type="OrthoDB" id="28394at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="2">
        <location>
            <begin position="122"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="482" mass="51337" checksum="1419AFA31644A625" modified="2013-03-06" version="1">MWEIGIIEFFLYVTLAASLLAPIFGIKNDKSVWPASIGAIGIGTFFVVSILTFYASLTNYLTFYNGLVIQDSFTALILLGASIASIIYIIAIGNDGLKWSSRPALYSLIPLVLFGLFFLSGATDALMIIASWLLVSVASYVFVSLPDGKESKEASIRYIMVGMIGTLILVFWAAVFAISPRADTNVFLLTSLAPTTKVGLSLAGLSILLIIAALGFKVGLFPFHWWLPSVYGRGDGRGISFVAGVIKLGFIAIITRAIVLMASSINGSSSIASYAALLIAFLAVASMIYGNIAALTSRNFQVILAYSSMAQVGYIFAAIAAAAYFAGNSDMNLLKLALFAVALQSIAYGIAKTPLFAFVGKTKRELSDLHGLLSANPAAAISASILLFSLLGIPPLLGFWGKLYLFLSASGYSVWLVLIALINSGISAVYYIIASRELLSKGENHITVGKGYTAALIISALALLIIGLYAPFLLKSIINIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACK5</accession>
    <name>L0ACK5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232687.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1068"/>
    <dbReference type="EnsemblBacteria" id="AFZ70790">
        <property type="protein sequence ID" value="AFZ70790"/>
        <property type="gene ID" value="Calag_1068"/>
    </dbReference>
    <dbReference type="GeneID" id="14212328"/>
    <dbReference type="KEGG" id="clg:Calag_1068"/>
    <dbReference type="eggNOG" id="arCOG00181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="YEPAHPY"/>
    <dbReference type="OrthoDB" id="43111at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="313" mass="35490" checksum="57D677768FC2E11B" modified="2013-03-06" version="1">MPILSIKNLSIHFYTPKGVRKAVDRVDLELNKGEVIGIAGESGSGKSTLALGIMRLITYPGRIVSGEIYFNGENILKMSEDEFNKKIRWKKIAMIFQGSMNGFTPVFKIGDQIREVMEIHEYNGDYESRIKELLNMVELDESVANKYPHELSGGMRQRAFIAMALALNPEILICDEPTTALDVITQAKIINLLKKLKKELNLSIIFITHDLALLSEISDKLYIMYAGGIMERGNSLDIYKNPKHPYTQLLIEAIADINKDYIKGIPGFMPDLANLPSGCRFSNRCPFVMDICKKKEPELKRLEGDRYVSCWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACL6</accession>
    <name>L0ACL6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Calag_1078</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1078"/>
    <dbReference type="EnsemblBacteria" id="AFZ70800">
        <property type="protein sequence ID" value="AFZ70800"/>
        <property type="gene ID" value="Calag_1078"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1078"/>
    <dbReference type="eggNOG" id="arCOG03199">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_4_0_2"/>
    <dbReference type="OMA" id="DDILGWK"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="PTHR10571"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="335" mass="37499" checksum="D6AA14D423E26F56" modified="2013-03-06" version="1">MITLAIAIISSLISFFVAYILIKAWINVAKREGLVGIDINKKDKREVAEAGGLWVVISTTFGLLIFEGIYVFTKNNYYSLNDLYSLVILLVLSAFLGFMDDILGWKKGVPQWIRIIAMIPMALPLMIAKYNAYVLSIPFFNKIYLGILYPLVIIPIGVLGASNAFNMIAGYNGLEVSNGLLLLLFTLIFSIIKGLYFIAFIILIVIGAMIAFLLFNWYPAKVFPGNTFTYAIGAFYAGLIIIGDFPKFGLTLFFLYYIELILFIRGLFHGIYKENFGKVNSDNSLDPPYDKSYSITHLAIKVLKKVKGKATERGVVIFIIILQLIVGIITLLLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACN0</accession>
    <name>L0ACN0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232712.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1093"/>
    <dbReference type="EnsemblBacteria" id="AFZ70815">
        <property type="protein sequence ID" value="AFZ70815"/>
        <property type="gene ID" value="Calag_1093"/>
    </dbReference>
    <dbReference type="GeneID" id="14212353"/>
    <dbReference type="KEGG" id="clg:Calag_1093"/>
    <dbReference type="eggNOG" id="arCOG00329">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_491446_0_0_2"/>
    <dbReference type="OMA" id="YTWLYIP"/>
    <dbReference type="OrthoDB" id="35869at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_B" evidence="4">
        <location>
            <begin position="284"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="624" mass="72781" checksum="C89AF38CAF6B7182" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACP0</accession>
    <name>L0ACP0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative redox protein, regulator of disulfide bond formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233091.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1492"/>
    <dbReference type="EnsemblBacteria" id="AFZ71194">
        <property type="protein sequence ID" value="AFZ71194"/>
        <property type="gene ID" value="Calag_1492"/>
    </dbReference>
    <dbReference type="GeneID" id="14212752"/>
    <dbReference type="KEGG" id="clg:Calag_1492"/>
    <dbReference type="eggNOG" id="arCOG02062">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165255_1_2_2"/>
    <dbReference type="OMA" id="CPGPLMD"/>
    <dbReference type="OrthoDB" id="124510at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="80" mass="8914" checksum="48ABDCA7BD8858AC" modified="2013-03-06" version="1">MSESGKKVVDARGLSCPGPITNLTKVYRNAKNGDVLEIWATDPGFKSDIKAWIERTKNELIELKEDKDKIVAVIKITAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACR7</accession>
    <name>L0ACR7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-associated phospholipid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1128"/>
    <dbReference type="EnsemblBacteria" id="AFZ70850">
        <property type="protein sequence ID" value="AFZ70850"/>
        <property type="gene ID" value="Calag_1128"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1128"/>
    <dbReference type="eggNOG" id="arCOG03056">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111005_0_0_2"/>
    <dbReference type="OMA" id="HVHWFSD"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="82"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="220" mass="25550" checksum="79B32FF0F4CD5ABB" modified="2013-03-06" version="1">MIKMKNSQKLIIATLILIVMIILEELKAFNGINTYFLSHINLKNNLLIKFITDTASLEAFIVYMVILYFGQAILRKNVTKNVVSFIIAIIISMIATLLIKAFTMIPRPYEIQPHWSLLKSLINADYFSFPSGHTVRVSVLAFYITYIFDTTKKGKLKYLSWIYALIIMYTRLALQVHFFSDLLAGVVVGIWSSLLVIYFENVWRKIYDFIFKKIKILNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACR9</accession>
    <name>L0ACR9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lhr-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232839.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1225"/>
    <dbReference type="EnsemblBacteria" id="AFZ70942">
        <property type="protein sequence ID" value="AFZ70942"/>
        <property type="gene ID" value="Calag_1225"/>
    </dbReference>
    <dbReference type="GeneID" id="14212485"/>
    <dbReference type="KEGG" id="clg:Calag_1225"/>
    <dbReference type="eggNOG" id="arCOG00557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_0_0_2"/>
    <dbReference type="OMA" id="LCLNCGW"/>
    <dbReference type="OrthoDB" id="6553at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="30"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="237"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="941" mass="106633" checksum="192535E1A4707898" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACV1</accession>
    <name>L0ACV1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine synthase II (Cobalamin-independent)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1256"/>
    <dbReference type="EnsemblBacteria" id="AFZ70972">
        <property type="protein sequence ID" value="AFZ70972"/>
        <property type="gene ID" value="Calag_1256"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1256"/>
    <dbReference type="eggNOG" id="arCOG01877">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040013_3_1_2"/>
    <dbReference type="OMA" id="YYDNNNF"/>
    <dbReference type="OrthoDB" id="88155at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="1">
        <location>
            <begin position="83"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="339" mass="38549" checksum="DBD447C5F27768D1" modified="2013-03-06" version="1">MVKLWGAVLGGYPRSIDVRHEMRDLERGDSIYLDHEILIAISSSSVIGAQVSSGLKYVTDGMLDFHDIFRPFLESWRNVSIAGLLRYFDNNFFYRIPIFTGEPDVEKFVWPQRIRFYKKVAYPSLLKAVIPGPLSLTLMGENHSNLSKEDLANSISSILSMEAEKAEKAGAGMIQIDEPILSDHEISEEDAELAKELISNIAKRVKIPTTLSIYFDIPKKEVYEKIIDTKVNYISLDIMDSPSRGLELIKSKGFSDKKPILGLIDSRRIYDDNCDKIKEIISNVLNLEKEEIGITTTTWFDVIPYNFAIRKTYLLGYCLEKLGNELNAEIINPIKEVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACZ4</accession>
    <name>L0ACZ4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Archaeal/vacuolar-type H+-ATPase subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1206"/>
    <dbReference type="EnsemblBacteria" id="AFZ70925">
        <property type="protein sequence ID" value="AFZ70925"/>
        <property type="gene ID" value="Calag_1206"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1206"/>
    <dbReference type="eggNOG" id="arCOG04102">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2270892_0_0_2"/>
    <dbReference type="OMA" id="VEANDQR"/>
    <dbReference type="OrthoDB" id="112180at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="103" mass="11115" checksum="6C2EA9C1810AEAA8" modified="2013-03-06" version="1">MIKLSSEGKLIVIGDRQSANLFKLAGITIIDANNQKEAEEGLKKAKEKGGTLAIILKHIVDDEASLRNLANSLNITLLILPTKWVKAEPINIDKLLAKALGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD00</accession>
    <name>L0AD00_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232827.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70930">
        <property type="protein sequence ID" value="AFZ70930"/>
        <property type="gene ID" value="Calag_1211"/>
    </dbReference>
    <dbReference type="GeneID" id="14212471"/>
    <dbReference type="KEGG" id="clg:Calag_1211"/>
    <dbReference type="HOGENOM" id="CLU_2067677_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="118" mass="13530" checksum="0FCBB1D398D61CFD" modified="2013-03-06" version="1">MILIDPNILWRTLEMGDIDLEGDKSNEIINLLRNKALNSFMGGYILLDNQSRAKYNISFIELLLRHPEYGCALGNEVLGEQFIILIRSILKGSEFDGIRDIIINNCNRIRNHKRNIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD10</accession>
    <name>L0AD10_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232837.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1221"/>
    <dbReference type="EnsemblBacteria" id="AFZ70940">
        <property type="protein sequence ID" value="AFZ70940"/>
        <property type="gene ID" value="Calag_1221"/>
    </dbReference>
    <dbReference type="GeneID" id="14212481"/>
    <dbReference type="KEGG" id="clg:Calag_1221"/>
    <dbReference type="eggNOG" id="arCOG04160">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084972_0_0_2"/>
    <dbReference type="OMA" id="FNAIMPD"/>
    <dbReference type="OrthoDB" id="53276at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="265" mass="30400" checksum="4A02D32CE438F34E" modified="2013-03-06" version="1">MPRKKSNKKDENKIKDPNNEISKTKKKSQKQAKLSNDEFNSFVNDISREIIDKFGLDLINLKPDDIKDLVEEIINSIVESRVTKPSEESLLKKFINSKDQFMKGIAGRLIERDEVNSRERLELIIAYAPEIAGRASPRLYKIAKQLNAIDLIDNLRQLWNRYGLSTPIRCPVCGFNSVMPDMSCIVCGSLLDEKDIKKEINLREQLSKLKNVYNDKLIREIIDSGYVVFDGEIKPPSLKEKDKISISLHLNKDEKDILLKLLSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD52</accession>
    <name>L0AD52_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-grasp superfamily enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232877.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1264"/>
    <dbReference type="EnsemblBacteria" id="AFZ70980">
        <property type="protein sequence ID" value="AFZ70980"/>
        <property type="gene ID" value="Calag_1264"/>
    </dbReference>
    <dbReference type="GeneID" id="14212524"/>
    <dbReference type="KEGG" id="clg:Calag_1264"/>
    <dbReference type="eggNOG" id="arCOG00347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075000_2_0_2"/>
    <dbReference type="OMA" id="EKYRWIP"/>
    <dbReference type="OrthoDB" id="115684at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="243" mass="27686" checksum="0193E79099178C05" modified="2013-03-06" version="1">MRRKVEIILNVNEEIFKDNVIITGFPGFGRVGYTAPKYLSLALQMKKVGYIMTERMPSVILVEDDGVGLPFEIYQNNNVTVLMNRAIPEIIDQNAFSKSISDWIKNMGFKYVVLIGGLSREFMSENETYWYRWISNTYYNGPKLEAPMMEKGLGVVGPLALLYIYLERLKIPTVMVLPYSIIEGVDYDAAFVGVKAILKNLLNMETAVPELEQLATKQREEIDKIVKMIQAESQKVGTSNIYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADB1</accession>
    <name>L0ADB1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nadE</name>
        <name evidence="9" type="ordered locus">Calag_1331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232937.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1331"/>
    <dbReference type="EnsemblBacteria" id="AFZ71040">
        <property type="protein sequence ID" value="AFZ71040"/>
        <property type="gene ID" value="Calag_1331"/>
    </dbReference>
    <dbReference type="GeneID" id="14212591"/>
    <dbReference type="KEGG" id="clg:Calag_1331"/>
    <dbReference type="eggNOG" id="arCOG00069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059327_1_1_2"/>
    <dbReference type="OMA" id="MVVQYAL"/>
    <dbReference type="OrthoDB" id="89944at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ71040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="274" mass="30704" checksum="1C4C8F5EEB2072C5" modified="2013-03-06" version="1">MKITINDVTNIDYEYARKNIEKFIKNELESSRKNGYVVGLSGGVDSALTYYLAAEAVGIEKVFALIMPDTTTTPKEDVNDAKDLVKRLKGQMNVIDISPIVEVYKSTIPIYQEEDNIPLGNVRARIRMTLLYYYANKMSMLVLGTGDRSESFVGYFTKYGDGGVDLLPISSLLKSQVRKLAQKLGVPDNVALKPSSPRLWVGQLAEKELGISYDQIDLIIYSVIDKGYSLKEASEMTGISLDIIQKVFDMNKNSEHKRTFPKSLSTNEVIKYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADE0</accession>
    <name>L0ADE0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
            <shortName evidence="4">PIMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pcm</name>
        <name evidence="5" type="ordered locus">Calag_1420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233024.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1420"/>
    <dbReference type="EnsemblBacteria" id="AFZ71127">
        <property type="protein sequence ID" value="AFZ71127"/>
        <property type="gene ID" value="Calag_1420"/>
    </dbReference>
    <dbReference type="GeneID" id="14212680"/>
    <dbReference type="KEGG" id="clg:Calag_1420"/>
    <dbReference type="eggNOG" id="arCOG00976">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055432_2_0_2"/>
    <dbReference type="OMA" id="TISAIHM"/>
    <dbReference type="OrthoDB" id="88476at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00090">
        <property type="entry name" value="PIMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="224" mass="25177" checksum="9605118AE7162313" modified="2013-03-06" version="1">MESFNKKMSLINYLKNSGFIKTKKVEEALINVDRANFVLSQYLSEAYEDKPLPIGYGQTISAPSIVAYMTELLEVNEGNKILEIGTGSGYQTAILSYLVKEKGLIVSIERIKELSEMAYKNLERLGLHKNVKLIVGDGSLGYEEEKPYDRIIITAATPVVPKFINMQLKNNGIAILPLGTLEEQKLAIIRKDEFGNIELRYDISVIFVPLIGYEGFKFGKEETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADE3</accession>
    <name>L0ADE3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exopolyphosphatase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233029.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1425"/>
    <dbReference type="EnsemblBacteria" id="AFZ71132">
        <property type="protein sequence ID" value="AFZ71132"/>
        <property type="gene ID" value="Calag_1425"/>
    </dbReference>
    <dbReference type="GeneID" id="14212685"/>
    <dbReference type="KEGG" id="clg:Calag_1425"/>
    <dbReference type="eggNOG" id="arCOG01565">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070736_0_0_2"/>
    <dbReference type="OrthoDB" id="47681at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="235"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="335" mass="37278" checksum="C9BDB9D57F63CA21" modified="2013-03-06" version="1">MIKTNTNNFLNDFINELKNGNIGISFHSNADLDAIASSLITYELCKRYNEKCCIDLKQGLSKESIIALKEINIEIKKCDFNYDKLILLDNAGIEQVSNLISNKNIPLIVIDHHREGKIFQISKLYYIDDDASSTTEIVSSFASKLTINLDENISTLGILGILFDSNRLERASKSTLESLLYLMKNGDYKKAISIYYKIIKGIEEDFSIKMAKLKGFSRAIIGKVCKDLIAVVTEIGSYESIVSRTLIQNGADVAFTIKYKEGEDIRISIRISDKAISKGIDASNIARIVADKYNGEGGGHIGASIVTIKNKKPIEKEKFFSYLVNLINGICKESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADE7</accession>
    <name>L0ADE7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:ubiquinone oxidoreductase 49 kD subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1430"/>
    <dbReference type="EnsemblBacteria" id="AFZ71137">
        <property type="protein sequence ID" value="AFZ71137"/>
        <property type="gene ID" value="Calag_1430"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1430"/>
    <dbReference type="eggNOG" id="arCOG01548">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_2"/>
    <dbReference type="OMA" id="IMGTSME"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="1">
        <location>
            <begin position="139"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="416" mass="47633" checksum="12CF981E4735DBDA" modified="2013-03-06" version="1">MESSTSSGSVPHLPGMEVTEVSKNTYEVYIGPAHPGSGHMRIIVEVDGDIMVRVDPDIGFVHRTMEKLAEGRDWIKNIPLFERMAILDACNITLPYVQAVERLLGTEPPERARYLRTLLCEINRIASHLYGMGIFGVFLGHSTLYMWAFGDREVFVDLAEQMTGARLTHSYPVFGGVRRDIPDDFPENARKAAKYMRNRLNEYAKIFLNNPNIRSRLENVGVMSKNLATELGIVGPNLRASGVRYDVRLNEPYEAYGDVEFEIPVFEEGDSLARAWARVEEIKQSLNIIEQVVDWLEKHPRENFMHEKFWKTAPKLYKDVFSGQIDYAGKYRVKLMPLFASLKVPPGKAFARVEAGRGEMVYYVESDGKDLPYRVRVVSPSFRNVIAFKYLMPGHRLMDLPTIYGSFDYFPPEWDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADH6</accession>
    <name>L0ADH6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps14</name>
        <name evidence="4" type="ordered locus">Calag_1381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds 16S rRNA, required for the assembly of 30S particles.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232987.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1381"/>
    <dbReference type="EnsemblBacteria" id="AFZ71090">
        <property type="protein sequence ID" value="AFZ71090"/>
        <property type="gene ID" value="Calag_1381"/>
    </dbReference>
    <dbReference type="GeneID" id="14212641"/>
    <dbReference type="KEGG" id="clg:Calag_1381"/>
    <dbReference type="eggNOG" id="arCOG00782">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177289_2_2_2"/>
    <dbReference type="OMA" id="HCFREIA"/>
    <dbReference type="OrthoDB" id="122051at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_A">
        <property type="entry name" value="Ribosomal_S14_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="40S_S29/30S_S14z"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023676">
        <property type="entry name" value="Ribosomal_S14_type-Z_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="PTHR12010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ71090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="54" mass="6278" checksum="3373781089FA848C" modified="2013-03-06" version="1">MGKYKPPKMKSMGRGAQRCQRCGTRDAVIQKYGLYLCRQCFREVAPTLGFKKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADI8</accession>
    <name>L0ADI8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1490"/>
    <dbReference type="EnsemblBacteria" id="AFZ71192">
        <property type="protein sequence ID" value="AFZ71192"/>
        <property type="gene ID" value="Calag_1490"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1490"/>
    <dbReference type="eggNOG" id="arCOG05379">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132454_0_0_2"/>
    <dbReference type="OMA" id="WAVFAQL"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018632">
        <property type="entry name" value="AAA-associated_dom_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09821">
        <property type="entry name" value="AAA_assoc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="148" mass="16647" checksum="B5351B29606179C3" modified="2013-03-06" version="1">MLNGFMDQFPLVYVDQVIGLVKYLNSIGGKVDSSRLDEMLDVDIDLLPHVIKAAEIIGLVKQSNGDLIVTEIGKKIEEAENKDMRIIMKKLIKNAEPFKDIISSAKKNQINIEKLREILEKNGYNNIDEAINVISQWLALIGINVIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADM8</accession>
    <name>L0ADM8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1539"/>
    <dbReference type="EnsemblBacteria" id="AFZ71237">
        <property type="protein sequence ID" value="AFZ71237"/>
        <property type="gene ID" value="Calag_1539"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1539"/>
    <dbReference type="eggNOG" id="arCOG01369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="OMA" id="NLGNEDW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="319" mass="35294" checksum="4AE8D1F1FF637235" modified="2013-03-06" version="1">MVNMKILITGGAGFIGSNLADYLVSKGYSVRVVDDLSFGSVDNLKDLIQEKNFEFIKGDLRDPEIANNSVKGIDIVYHLAANPEVRISSQSPSSLYELNVYLTYNILEAMRKNNVKVLAFASSSTVYGEAKKIPTPEDYGPLEPISVYGGAKLASEALISSYSHTFKLNSVSFRLANVIGKRSNHGVIHDFIEKLKKDKTRLEILGDGTQSKSYIHVSDVIEGMHYLLNKNLEKNIIYDVYNIGSDDQVTVMDIAKIIIEKMGLNPKIYLTGGVDGGRGWIGDVKYMLLSIEKAKSIGWRPKLNSYEAVKRAVDEALNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADU2</accession>
    <name>L0ADU2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penicilin amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233112.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1515"/>
    <dbReference type="MEROPS" id="S45.003"/>
    <dbReference type="EnsemblBacteria" id="AFZ71215">
        <property type="protein sequence ID" value="AFZ71215"/>
        <property type="gene ID" value="Calag_1515"/>
    </dbReference>
    <dbReference type="GeneID" id="14212776"/>
    <dbReference type="KEGG" id="clg:Calag_1515"/>
    <dbReference type="eggNOG" id="arCOG04082">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011790_4_0_2"/>
    <dbReference type="OMA" id="EMDVRRH"/>
    <dbReference type="OrthoDB" id="3179at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="847" mass="95359" checksum="50DFDE67EE88E15D" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7P2</accession>
    <name>L0A7P2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Superfamily II DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0049"/>
    <dbReference type="EnsemblBacteria" id="AFZ69841">
        <property type="protein sequence ID" value="AFZ69841"/>
        <property type="gene ID" value="Calag_0049"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0049"/>
    <dbReference type="eggNOG" id="arCOG00560">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254017_0_0_2"/>
    <dbReference type="OMA" id="QVEPWDL"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="677"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="911"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ69841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="1405" mass="160677" checksum="F513B9D852C60C24" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7R1</accession>
    <name>L0A7R1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gamma-aminobutyrate permease-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231806.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0120"/>
    <dbReference type="EnsemblBacteria" id="AFZ69908">
        <property type="protein sequence ID" value="AFZ69908"/>
        <property type="gene ID" value="Calag_0120"/>
    </dbReference>
    <dbReference type="GeneID" id="14211380"/>
    <dbReference type="KEGG" id="clg:Calag_0120"/>
    <dbReference type="eggNOG" id="arCOG03650">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596665_0_0_2"/>
    <dbReference type="OMA" id="SVFGCYL"/>
    <dbReference type="OrthoDB" id="30796at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="21"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ69908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="458" mass="50261" checksum="0B36BF0FF476DEF8" modified="2013-03-06" version="1">MKKENKLQKDAVSIIGDFFNSLGGQAPTYSIAGGTALILSTSYASSPLAMLITLIGVLAIVYSVFILSKRYSHSASFYYYVSKVLGTPTGYFNGIIYTIFYSIIGVGSVAIAFAYLGYEGILASTGIKVNPLVLIAIPIIISFIIAYFGIKPSIKSEVVIATIEIGILLLFVGFSFFYNIHNLTLYPFTLKGTFTNSLKGELAAISGGLIFGITYFMGFEVSTQLGEESKDPNKAIPTSTLFSTIIMGFLYIIVTYAIILNVGFNYNSISSFIAQAQGAGLNPVYILMKKYLGNPGLIIFSILTMFSVFGCYLATLNATARMIYGMSKENLLPKKFEEVNKYKSPKNALIISTLLSSIIIILFYLLSFNSGSLVEQTYNAMENAYAIDSLYYVISLAFLSISAFSLTNVKGKIISIIGLVILAITFYYSIVNLYYLIAVVLTAIFVIISYFYIKRWVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7X6</accession>
    <name>L0A7X6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Altronate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0150"/>
    <dbReference type="EnsemblBacteria" id="AFZ69936">
        <property type="protein sequence ID" value="AFZ69936"/>
        <property type="gene ID" value="Calag_0150"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0150"/>
    <dbReference type="eggNOG" id="arCOG05317">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029189_1_0_2"/>
    <dbReference type="OMA" id="DVGWELF"/>
    <dbReference type="OrthoDB" id="27446at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007392">
        <property type="entry name" value="Gal/Altron_deHydtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04295">
        <property type="entry name" value="GD_AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GD_AH_C" evidence="2">
        <location>
            <begin position="5"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="388" mass="42063" checksum="659A940AE19E45FC" modified="2013-03-06" version="1">MMKELFGYVRENGDVGFRNKVLIMPTVSCSSLAAFRIHQLVNGTAYVDNQYGCGQLKPDLELTEKTLINFAKNPNVSSVLLVSLGCESADYEKIADKIAETNKWVELLVIQEVGSTIDAIEKGVRIAKEMVEKNNKNRERVDWNSLILSAECGGSDFTSGIASNPVVGYVMDKVVELGGTTVISETTEAIGAEHILARRAINDEVREKFLKIVKRVENLSLSTGEDIRGSNPSPGNIKGGITTLEEKSLGAIEKGGRKSKLVDAIEYADLIPKKNGLIFMDTPGYDVQSVVGMVAGGSQAVLFTTGRGTPTGNPISPVIKITANPETFKKMGDNIDFDASPIIKGEDTIENLGEKLFSLLVDVLNGKLTKSEILGHQEFGIMKIYQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0A847</accession>
    <name>L0A847_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_0224</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0224"/>
    <dbReference type="EnsemblBacteria" id="AFZ70006">
        <property type="protein sequence ID" value="AFZ70006"/>
        <property type="gene ID" value="Calag_0224"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0224"/>
    <dbReference type="eggNOG" id="arCOG01185">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063953_2_0_2"/>
    <dbReference type="OMA" id="HKLYMEY"/>
    <dbReference type="OrthoDB" id="100186at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="PTHR12209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="13"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="230" mass="26964" checksum="7501828D745EB9B8" modified="2013-03-06" version="1">MVLFDDLINPEKFLNLQLIKRGAESEIRLGYFLSTKAIYKIRVKKIYMNDDLDKDLRYDRTRREAKILATAYLNRINVPKLYAVYPSVGLIIMEYIEGNTLKDLFLYEPEKYIPFSYFAGIELAKIHKANIIHNDYTTSNIIVRDEKVFVIDFGLSDYSTSIEDKAVDIHLYKRAVESTHASISEKIMKEFIRGYLKETGEEIGNKIIKRAKEIELRGRYVGERRTVWKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A864</accession>
    <name>L0A864_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231924.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0244"/>
    <dbReference type="EnsemblBacteria" id="AFZ70026">
        <property type="protein sequence ID" value="AFZ70026"/>
        <property type="gene ID" value="Calag_0244"/>
    </dbReference>
    <dbReference type="GeneID" id="14211504"/>
    <dbReference type="KEGG" id="clg:Calag_0244"/>
    <dbReference type="eggNOG" id="arCOG00856">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_5_2"/>
    <dbReference type="OMA" id="DFGGWKI"/>
    <dbReference type="OrthoDB" id="13052at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="38"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="457"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="557" mass="63065" checksum="C4B67160EE4407EA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8C8</accession>
    <name>L0A8C8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="6">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_0331</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232006.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0331"/>
    <dbReference type="EnsemblBacteria" id="AFZ70108">
        <property type="protein sequence ID" value="AFZ70108"/>
        <property type="gene ID" value="Calag_0331"/>
    </dbReference>
    <dbReference type="GeneID" id="14211591"/>
    <dbReference type="KEGG" id="clg:Calag_0331"/>
    <dbReference type="eggNOG" id="arCOG01599">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_0_0_2"/>
    <dbReference type="OMA" id="PEWCPGC"/>
    <dbReference type="OrthoDB" id="43666at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="9">
        <location>
            <begin position="49"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PFO_beta_C" evidence="10">
        <location>
            <begin position="200"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="310" mass="34538" checksum="D6A756266390CB45" modified="2013-03-06" version="1" precursor="true">MARNWSDYKTNSWVQWCPACGNFGILLAVQKAFAELNLPPEKVSIVSGIGCSSRIPYYVKSSNIHTLHGRPIPVAEGIKLANPEQTVVVASGDGDLLGIGAGHFVALGRRNMQIAILLHDNAVYGLTKGQAAPTLPLWVKTKALDSPNIQSQVNPLLLAFASGYTFIARAYAYHVDQLKDLIKAAINHKGTSLIDILQPCPTYNDIMTKEWYEKRIYYLTSEDPSWDPLVSSSEDFDAKAPKILNKMTEWGDKIPLGIFYVNMSVEPLDTRIEKILPGYLQYPPAKRPIEIKSKPLVHPFTEFKDRIVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8D4</accession>
    <name>L0A8D4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-guanine dinucleotide biosynthesis protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0336"/>
    <dbReference type="EnsemblBacteria" id="AFZ70113">
        <property type="protein sequence ID" value="AFZ70113"/>
        <property type="gene ID" value="Calag_0336"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0336"/>
    <dbReference type="eggNOG" id="arCOG01872">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_975209_0_0_2"/>
    <dbReference type="OMA" id="RICDEYS"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="8"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="285" mass="32960" checksum="D7650DB4B54523D9" modified="2013-03-06" version="1">MNKMEIAAIILAGGKSTRFAEDKLIYLYNNKPIISYPINESEKITDNVFVVTNDKEYEKLRKVINVEFIFDDPSFKCEGSSRGIASAIKAIDANYYLIMPGDIPWIHYIALKNLLEYAKRTQYLVSPIIYSGIVSPLFLAFPKSYKDNISRICDEYSVLASRPSNFIRGNKSLLIGSYHLTDNPRVFYDVDTKLDLTTHTRGLPRKIVYLESYKYFIDGIENLKNGENDEAFKDFINESKIYKINKLNSLELSCLIDAFLINKDEKIQKRINVLRKKLGRRPKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8G9</accession>
    <name>L0A8G9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ordered locus">Calag_0339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232014.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0339"/>
    <dbReference type="EnsemblBacteria" id="AFZ70116">
        <property type="protein sequence ID" value="AFZ70116"/>
        <property type="gene ID" value="Calag_0339"/>
    </dbReference>
    <dbReference type="GeneID" id="14211599"/>
    <dbReference type="KEGG" id="clg:Calag_0339"/>
    <dbReference type="eggNOG" id="arCOG01323">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089358_3_1_2"/>
    <dbReference type="OMA" id="SGPGMTR"/>
    <dbReference type="OrthoDB" id="88531at2157"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="44"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="68"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="151" mass="16721" checksum="6D2B0E7F2B213B31" modified="2013-03-06" version="1">MNVRLGLVIAEFNYDITKIMEEKAISHARFLNAEVPIVFKVPGVYDSPFAVSKLLRLNYIDAVSVLGAVIQGETKHDELVANQAARMLIDLSEKYGKPVTLGIIGPGASRMQALERSEEYSRRAVEAAVKLVLRSKMLDEVKYEGKLLTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8L7</accession>
    <name>L0A8L7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232111.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0445"/>
    <dbReference type="EnsemblBacteria" id="AFZ70213">
        <property type="protein sequence ID" value="AFZ70213"/>
        <property type="gene ID" value="Calag_0445"/>
    </dbReference>
    <dbReference type="GeneID" id="14211705"/>
    <dbReference type="KEGG" id="clg:Calag_0445"/>
    <dbReference type="eggNOG" id="arCOG00666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_1_2"/>
    <dbReference type="OMA" id="TAIVEHK"/>
    <dbReference type="OrthoDB" id="61185at2157"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023915">
        <property type="entry name" value="Bifunctiontional_GlmU_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03992">
        <property type="entry name" value="Arch_glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="415" mass="46606" checksum="46220884C3E63646" modified="2013-03-06" version="1">MKLVLLAGGKGERLRPLTDNKQKALMPILGEPLICRHLKELSKLNPEKIIIILSYKKEQVVEEVKKCFPNENKIVYVDQKEEKGTGHAIKMAMDYGGEGDYLIIYSDLYLSKNVYKNLIKLKSPGIVVTEVSKPWNYGVVKIENEIIKDIKEKPKIDEPVSNTIFAGILRLPFDSKEYIDNIKLSSRNEYEVTDAIKEMIKSFDIFTLNIPKNQWLDIGRPWDLLIANRLALDEEIKGQVIKGDVHNSVVIKGDVIIEEGAEIKPYTVIEGPVFISKNSIIGPTSHLRPYTIFLKNSSAGYSVEVKGSIVMEFSKLPHFNYVGDSIIGEHVNLGAGTITANLRFDHKSIKMKVKEDIIDTEMEKLGSIIGDYAQTGINVSILPGKKIGSHAIIYPGCIVDRDVNSYEIFKCKNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8R8</accession>
    <name>L0A8R8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232166.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70268">
        <property type="protein sequence ID" value="AFZ70268"/>
        <property type="gene ID" value="Calag_0503"/>
    </dbReference>
    <dbReference type="GeneID" id="14211763"/>
    <dbReference type="KEGG" id="clg:Calag_0503"/>
    <dbReference type="eggNOG" id="arCOG04211">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2565896_0_0_2"/>
    <dbReference type="OMA" id="DKWYTKP"/>
    <dbReference type="OrthoDB" id="129348at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="92" mass="10478" checksum="D3FEF8AA13DCF922" modified="2013-03-06" version="1">MSDYLDQVKDAIRAEITKNGLKIESRGKNSFALTKEGADFMIVRDSDEQVEISYKGQRYQYDKYYTKPQHLAQVITNVMNAALGINKQAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8V4</accession>
    <name>L0A8V4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232179.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0517"/>
    <dbReference type="EnsemblBacteria" id="AFZ70281">
        <property type="protein sequence ID" value="AFZ70281"/>
        <property type="gene ID" value="Calag_0517"/>
    </dbReference>
    <dbReference type="GeneID" id="14211777"/>
    <dbReference type="KEGG" id="clg:Calag_0517"/>
    <dbReference type="eggNOG" id="arCOG04238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003258_0_0_2"/>
    <dbReference type="OMA" id="KRIEYYV"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="277" mass="31299" checksum="E8B428706876EC61" modified="2013-03-06" version="1">MIKDIKRALMITLTSPVKPGSIHRFMPEIEFEERIVEALEVFDIMDEAYRRGKELALGNIDSRSLGLGHLISSAYKNAFDSINERPLPGLDAAAIVLSSIDGYSEGIKQNVINGINSFLSRILYKGKPRDAVEFVESLEDLGLSNYINLLERSGITKESIEYEERSLGDVFEILSKIDSGFLLNLKHYSNLLKFSKMLMNSKNVIQAALKSYVYIGKDLFKIEEFSDLDINDPNILSKLLSKDKLLKRNREDLNAILGGVLIILYFSLNNENPLKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Z8</accession>
    <name>L0A8Z8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="10" type="ordered locus">Calag_0111</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0111"/>
    <dbReference type="EnsemblBacteria" id="AFZ69899">
        <property type="protein sequence ID" value="AFZ69899"/>
        <property type="gene ID" value="Calag_0111"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0111"/>
    <dbReference type="eggNOG" id="arCOG04133">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_0_0_2"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="294"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ69899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="376" mass="41865" checksum="7851120B24CE7324" modified="2013-03-06" version="1">MGRIFKITTFGESHGKALGVVIDGLPSGLIISEDDIFFELKYRRPGGIYTSTRKEEDYPIILSGIFNGKTTGMPISIIIENKDPKSIHYEEIKYKPRPGHADITYIEKYGYENWDYRGGGRSSGRETVSRVAAGAIAKKLLLLTDTIVAGYIKKAGTFNVDNTPEFNEILCSRDSPVRTIRNKEGELMKLIETLRKEGDSIGGIVEVVVKNPPKSLGEPVFDKLKADLAKSILSIPGVVGFEYGIGFDSYKFKGSEVMDEIYYDEKFRLRKNISGGILGGISTGEDIILRVAFKPTSSIAKEQKTIDLRDLKPTNLSIIGRHDPCIAIRGVSVVESMVAITLIDHYMLSGIIPRKLSKEQADIIEKRWSEYKQKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A957</accession>
    <name>L0A957_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gamma-aminobutyrate permease-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0649"/>
    <dbReference type="EnsemblBacteria" id="AFZ70401">
        <property type="protein sequence ID" value="AFZ70401"/>
        <property type="gene ID" value="Calag_0649"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0649"/>
    <dbReference type="eggNOG" id="arCOG00009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_16_0_2"/>
    <dbReference type="OMA" id="QVPYAGI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="641" mass="69772" checksum="55E69E91E83C068A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0A965</accession>
    <name>L0A965_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232309.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0660"/>
    <dbReference type="EnsemblBacteria" id="AFZ70411">
        <property type="protein sequence ID" value="AFZ70411"/>
        <property type="gene ID" value="Calag_0660"/>
    </dbReference>
    <dbReference type="GeneID" id="14211920"/>
    <dbReference type="KEGG" id="clg:Calag_0660"/>
    <dbReference type="eggNOG" id="arCOG00467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025112_3_2_2"/>
    <dbReference type="OMA" id="YLFYENE"/>
    <dbReference type="OrthoDB" id="58376at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc6_C" evidence="4">
        <location>
            <begin position="313"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="60"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="414" mass="46586" checksum="8CEAE5C2292DE6F2" modified="2013-03-06" version="1">MSGKIFTNRGVFDETYIPSTLLVRDSEANVLITRYLSRLGEGSGSTDVTVLYGSIGKVGIGKTTLAKYVSRVLSKKAEDKGINFKPVYINVYGASSLHQILSRIVSELEMNIPVRGNATIEVLKAISDFLYIKDAYALIILDEFQSLLMSSKLSDDEFYLLLRVYEEIPPKDNINRLNFMLVSQDFRILSYMKERIPQVESQIGFRVHLRPYSSDELKTIIEQRAIEGLYENSYNQDILNMIADYYGYNDIKGGEGSARKAILTLRMAAEIADAENSGRIEERHVREALSTNAVSNIPLDIIRALSLHELLILQSISNLLVAKGGWLTSGEVEDEYSHLSYAYGEEPRKHTQFYEYIKNLNNMGLIESKISGKGIRGKTTIIRLPLDIPAERLKEVLESILLDRIGGPKPEQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A967</accession>
    <name>L0A967_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231867.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0185"/>
    <dbReference type="EnsemblBacteria" id="AFZ69969">
        <property type="protein sequence ID" value="AFZ69969"/>
        <property type="gene ID" value="Calag_0185"/>
    </dbReference>
    <dbReference type="GeneID" id="14211445"/>
    <dbReference type="KEGG" id="clg:Calag_0185"/>
    <dbReference type="eggNOG" id="arCOG02691">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_39_0_2"/>
    <dbReference type="OMA" id="THTNDPT"/>
    <dbReference type="OrthoDB" id="38526at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="5">
        <location>
            <begin position="12"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="429" mass="47135" checksum="EC3877E30661EFC7" modified="2013-03-06" version="1">MVYGLNKQQWIEVLSAWLGWLLDGYTTIGYALVGLTISTVFFPPSLKVAGIVLTFAGFGVGALARSIGSLVFGNYLGDKLGRKNMLITTILGFSFLSASKSILPSYNQVGIIAPILLYIILFFEGMFAGAEYGGGSTLAMESTPPERRGFVGSFVQSGYGTGYFIVSLVLTGISLVTGKAFSTIGWRILFATALIPGLIAFLMRLFAKETKIFEEMKGKNEIERVPLKSLFKYSPKQMIIGLLITTGLLGVNTATFSFWPSVMNELKYDESLIGIGVAIINLISLFGVWFGGFIADKIGGRKIPMLIYALLFAITSYFLIVYGYTRNFEIFVTLFSIQAFIEAMIFSTIPAFLSEIFSRKYRTTGVGFTYNGGAIVGGFAISMIYAISYLGLLNAWIIILYLFTAIMLIGIILAQETWGRKINKDLIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9C1</accession>
    <name>L0A9C1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="8">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tyrS</name>
        <name evidence="10" type="ordered locus">Calag_0754</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0754"/>
    <dbReference type="EnsemblBacteria" id="AFZ70498">
        <property type="protein sequence ID" value="AFZ70498"/>
        <property type="gene ID" value="Calag_0754"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0754"/>
    <dbReference type="eggNOG" id="arCOG01886">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035267_1_1_2"/>
    <dbReference type="OMA" id="VATWHAW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02009">
        <property type="entry name" value="Tyr_tRNA_synth_type4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023678">
        <property type="entry name" value="Tyr-tRNA-ligase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="237"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="362" mass="41327" checksum="A5945D8F072C65BB" modified="2013-03-06" version="1">MQKFLDAYEKFELIKKNLAEVLTENELKEKIENGIKMKGYLGFEPSGLPHLGWIVWMNKVKDLIDAGVEFNLLEATWHAMINDKLGGNMELIRKAARLTRDVMKALNVQVDKINFVDAEKMARDKDYWALVIKVMKMTSLARMKRALTIMGRNMDEADLDTSKLIYPAMQVSDIIYMDLDIALGGLDQRKAHVLAREIAEKINAKKPIGLHTPILTGLDGGKRMETGEIDEQAASYKMSKSKPNTAIFVNDSEEDIKNKIMNAYCPPRQTEFNPILDINKYLLFPQNGFKLVIERPEKYGGTIIFEKYNELENEYANGKVHPLDLKTATANSLIEMLKPVRKLFEKDDIKELAQEILKGITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9F7</accession>
    <name>L0A9F7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231952.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0274"/>
    <dbReference type="EnsemblBacteria" id="AFZ70054">
        <property type="protein sequence ID" value="AFZ70054"/>
        <property type="gene ID" value="Calag_0274"/>
    </dbReference>
    <dbReference type="GeneID" id="14211534"/>
    <dbReference type="KEGG" id="clg:Calag_0274"/>
    <dbReference type="eggNOG" id="arCOG05400">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131895_1_0_2"/>
    <dbReference type="OMA" id="PRYWRGH"/>
    <dbReference type="OrthoDB" id="93730at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="137" mass="16293" checksum="93A255FC5B0E757B" modified="2013-03-06" version="1">MVYFRLEKEFNKDSNELWKLIADIKSIPKYWHGHKSINIIHQDNNTIEAIVEFVFPSKARVKYELNEKNKEVISYYLDGPFKGKSILKIDKGKLINEWDIKFNGIYKFLSFWEVNHFKKGSEDALNRIVNYQISNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9H0</accession>
    <name>L0A9H0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mn2+-dependent serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232440.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0802"/>
    <dbReference type="EnsemblBacteria" id="AFZ70543">
        <property type="protein sequence ID" value="AFZ70543"/>
        <property type="gene ID" value="Calag_0802"/>
    </dbReference>
    <dbReference type="GeneID" id="14212062"/>
    <dbReference type="KEGG" id="clg:Calag_0802"/>
    <dbReference type="eggNOG" id="arCOG01186">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_610613_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="452" mass="51353" checksum="CB80F2914183D556" modified="2013-03-06" version="1">MEGEIKGINYKIKIVNGFKLPTFENNTLVVGDLIFSADVKLSTLGDVVSGLLIPPVEYDDTIKSLVEYYKLRVTIEQAYEISQRYGELANKIRIPIEFIPLSRMQPLRNIYSCIFNDVIDKIGVEGLRKEYEDYIKNIGSNVNGNINLNFDLLNISTNKIMGNIGKNVILGFLTMYSGNNFSIGKTCKPNELIENPYSLLSLPEGSILNSCNDLDNYIKNILGYNYSCKRPGLLFSSQICENDKNKVVIKEYMYGTLKWFMAGAVSASIFPFKETPLARLGNEYNSLIDLRKIVNTPKILSICIDKYEYKMMREFIKGEVVLKSKNPYVWSDLGSTLALIHNNNRTLGDSNPGNFVVTDEDKMTLIDAEQVSNYTPKKAAWDIAVFYAYARTFQANSRLVREALGSYVNSRPKDEWKKVLNYIKGPHLTMLMTPLPNLLTELRLTLRELDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9L9</accession>
    <name>L0A9L9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative anaerobic dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232468.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0830"/>
    <dbReference type="EnsemblBacteria" id="AFZ70571">
        <property type="protein sequence ID" value="AFZ70571"/>
        <property type="gene ID" value="Calag_0830"/>
    </dbReference>
    <dbReference type="GeneID" id="14212090"/>
    <dbReference type="KEGG" id="clg:Calag_0830"/>
    <dbReference type="eggNOG" id="arCOG00937">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01492">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02183">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_4_0_2"/>
    <dbReference type="OMA" id="YSANCIV"/>
    <dbReference type="OrthoDB" id="1029at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="209"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="665" mass="76717" checksum="E4BA8F6E888B1BDC" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9M0</accession>
    <name>L0A9M0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231992.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0316"/>
    <dbReference type="EnsemblBacteria" id="AFZ70094">
        <property type="protein sequence ID" value="AFZ70094"/>
        <property type="gene ID" value="Calag_0316"/>
    </dbReference>
    <dbReference type="GeneID" id="14211576"/>
    <dbReference type="KEGG" id="clg:Calag_0316"/>
    <dbReference type="eggNOG" id="arCOG01075">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_20_2_2"/>
    <dbReference type="OMA" id="PHAALWR"/>
    <dbReference type="OrthoDB" id="116493at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="156" mass="17518" checksum="7F2F8F7B76134D5C" modified="2013-03-06" version="1">MGRTYPNNPLVGVGTLLIRDNKILLIKRLNDPERGKWAIPGGHVELGEKLMDAAKREFLEETNIDTEPLGVVNVDEIITKQENKVLFHYVLITVLMKDNGKTPKAGSDAEDVKFVDLKDTKKLNDISITTQRLITKILTNEVNLERPIPVITSSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9M5</accession>
    <name>L0A9M5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232485.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0847"/>
    <dbReference type="EnsemblBacteria" id="AFZ70588">
        <property type="protein sequence ID" value="AFZ70588"/>
        <property type="gene ID" value="Calag_0847"/>
    </dbReference>
    <dbReference type="GeneID" id="14212107"/>
    <dbReference type="KEGG" id="clg:Calag_0847"/>
    <dbReference type="eggNOG" id="arCOG05890">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1060058_0_0_2"/>
    <dbReference type="OMA" id="MYEFPLA"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="257" mass="29348" checksum="0ABD73F023843629" modified="2013-03-06" version="1">MKLKSYSSAILLGFPIPESSNPYIAVPIKEVTLNININKCNSPLVYLENFPNELNEYIKNFWIKLNNGLDERLCANIKLENDFKDSTYSGLYSVTTSLLLYALGKYNNETLSEEEIIELSRITDNIQDPSWAAVLDSLRYSSITGNTVVYRNDEENSTLIKTIFPIKFDKVITLRQRLTKEMLGNDVYGAIIHLMGISVLEASINIRELNNFNKVFNKFRIITDSLSQIVWDLKTSDNCFYVPGLPNTAEKICIENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9T4</accession>
    <name>L0A9T4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-binding protein Calag_0410</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0410"/>
    <dbReference type="EnsemblBacteria" id="AFZ70179">
        <property type="protein sequence ID" value="AFZ70179"/>
        <property type="gene ID" value="Calag_0410"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0410"/>
    <dbReference type="eggNOG" id="arCOG04179">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122978_3_0_2"/>
    <dbReference type="OMA" id="KPQFGEQ"/>
    <dbReference type="OrthoDB" id="130316at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00026">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022889">
        <property type="entry name" value="DNA_bind_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PTHR10840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="SSF46950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="122" mass="14676" checksum="818C8169A08F50BD" modified="2013-03-06" version="1">MRCLSDNYSDYNDDELEELKQRRLLELRKKLEEEQRRKKLEEEQEAQKLAVLRAIMEPEALDRLSNLKLVKPELANIAEETIIRLVQMGRLSTPVTDDIVKNILIELDNRSRKEYEFKFKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9V0</accession>
    <name>L0A9V0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Daunorubicin resistance ABC transporter ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0886"/>
    <dbReference type="EnsemblBacteria" id="AFZ70626">
        <property type="protein sequence ID" value="AFZ70626"/>
        <property type="gene ID" value="Calag_0886"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0886"/>
    <dbReference type="eggNOG" id="arCOG00196">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="ISMPAPD"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="329" mass="37210" checksum="16CA500B36B0728F" modified="2013-03-06" version="1">METVIEVKNLTKKYGDFVAVDHINFNINKGEVFSLLGPNGAGKTTTIGMLSTIKRPTEGDAFILGHSIVKQKYYVRKLIGVSPQDLTADDELTGYENVLIMAKLFGYRGKDAEERAKWALEFMDLWDSAFKKVREYSGGMRRRLEVSMSIVHNPAVVFLDEPTVGLDVQSRRHIWELIRDLKKNGTTVLLTTHYMEEAESLSDRVAIIDHGKIIAIGTPDELKAKIKGDRIYVTLKDTDHMDEIIAKINDILPNSTNKVDGQILIKTESSSEFLPQLIKILSDHEVVELKVVKPNLEEVFLELTGKGLKEDEGGFDRFKYMRVVRGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9V8</accession>
    <name>L0A9V8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231738.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0048"/>
    <dbReference type="EnsemblBacteria" id="AFZ69840">
        <property type="protein sequence ID" value="AFZ69840"/>
        <property type="gene ID" value="Calag_0048"/>
    </dbReference>
    <dbReference type="GeneID" id="14211308"/>
    <dbReference type="KEGG" id="clg:Calag_0048"/>
    <dbReference type="HOGENOM" id="CLU_191161_1_0_2"/>
    <dbReference type="OMA" id="FHYIANQ"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="83" mass="8793" checksum="AF81C956DED8D34D" modified="2013-03-06" version="1">MSLQALQQIFGTIVSHIPGVSANGLSYYIALAGMAILLTFVITGVIILLVKAFRATWNLTPSGFLKLLLTLGIILIIVGIVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9W8</accession>
    <name>L0A9W8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232585.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70688">
        <property type="protein sequence ID" value="AFZ70688"/>
        <property type="gene ID" value="Calag_0965"/>
    </dbReference>
    <dbReference type="GeneID" id="14212225"/>
    <dbReference type="KEGG" id="clg:Calag_0965"/>
    <dbReference type="eggNOG" id="arCOG00144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_3_2"/>
    <dbReference type="OMA" id="HWIFWIS"/>
    <dbReference type="OrthoDB" id="42639at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="560" mass="60275" checksum="CFF55D8A0C86A94E" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Y9</accession>
    <name>L0A9Y9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gamma-aminobutyrate permease-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231768.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0080"/>
    <dbReference type="EnsemblBacteria" id="AFZ69870">
        <property type="protein sequence ID" value="AFZ69870"/>
        <property type="gene ID" value="Calag_0080"/>
    </dbReference>
    <dbReference type="GeneID" id="14211340"/>
    <dbReference type="KEGG" id="clg:Calag_0080"/>
    <dbReference type="eggNOG" id="arCOG00009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_16_0_2"/>
    <dbReference type="OMA" id="AWAYFAT"/>
    <dbReference type="OrthoDB" id="15038at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="511" mass="56436" checksum="68E865983758D2F4" modified="2013-03-06" version="1">MGFRKELGFWHVLFLTLGAIIGDAVAFIPVYVLGYDGPAGILSWIVAFLLIVPVALVVIELGTMWPRAGGIAYYPAKSNGPIAGSINGWSAFLGYALVTPSSIIAFVEYLAYYFPSLYKSGFLTILGIIVSAVIALITYLINNKHVGLIGNINNYLTVLKIIMVMIPVLALFAFFNAKNFNSPSLGGFMPVNLGAIGFFTAVTSTILAYAGFKQPVNYSEEVKDPGKFIPKAVIASLIITMIIYLVESIAFLGVTDKVISNPSQWSSLISLPYPYITALTSVRIPSNLLLIFIFLMIAGTIIASYTDALIYFGGASRVGYSLSVYDRYFPKIFSKLNKEGVPYISNILIFVLSIIYLLLLPSFETIFTVLIDAFIFSYAPLAISVAVFRSRYPNENRPFRIPAFKVLSPIAFVIGGLLIYWSGWSAVFIAGISVLIGLLFIIYYHKSVGIKRGDFIAGGWLPLYLISTMIISYFGSSNLNKIPFPYDNILFIIVSLMFYYWGYEAGKKYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA00</accession>
    <name>L0AA00_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231778.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ69880">
        <property type="protein sequence ID" value="AFZ69880"/>
        <property type="gene ID" value="Calag_0092"/>
    </dbReference>
    <dbReference type="GeneID" id="25396751"/>
    <dbReference type="KEGG" id="clg:Calag_0092"/>
    <dbReference type="eggNOG" id="arCOG02703">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129117_0_0_2"/>
    <dbReference type="OMA" id="WAVDPDP"/>
    <dbReference type="OrthoDB" id="67424at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="3">
        <location>
            <begin position="35"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ69880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="183" mass="20661" checksum="67BC469FAACF74D0" modified="2013-03-06" version="1">MLGDPEDRHFSPFILDNPIRKIIDNPRKIIKRYIKEGDYVADIGAGPGVYTIELAKLVGEKGKVYASDSDPKMVQVLKKKINKLNLKNVIVELASADNIKFIESNTIDFAFSNGVLCCMVNHKGAIEEINRILKEKGIAFISVEKISKGPTAIPKNEWRDLINKFNIIEEREGLFNRYAIISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA01</accession>
    <name>L0AA01_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Calag_0953</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0953"/>
    <dbReference type="EnsemblBacteria" id="AFZ70681">
        <property type="protein sequence ID" value="AFZ70681"/>
        <property type="gene ID" value="Calag_0953"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0953"/>
    <dbReference type="eggNOG" id="arCOG00422">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029960_1_1_2"/>
    <dbReference type="OMA" id="HAIYYPP"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="14">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="15">
        <location>
            <begin position="164"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="12">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ70681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="331" mass="39397" checksum="28470A2CD444FBE1" modified="2013-03-06" version="1">MARDLRELRYNPITGQWIMVSSVRRERRWRPTNYCPFCPGAEETGYGWDTLVLLNKFAVLSFESEDVKSKGFYRKTKANGECGVIIETPIHDIKDLDEFSIEQLVKVIKQWINITEKYIKDKRIIYLMIFRNKGEEIGVSLTHPHGQYYAMPFIPLRIRNMIQNSRNYFKRYNECIFCKIIKEEAREKVRVIYENQNFITFLPYYASWPFELHIYPKNHLQYITQLNEDQIIDFADALKLSLSVLNNLFNREMPYSFALIQAPLRGNYHDIFHMHLEIYPILRDKDKIKYAAGIEMSTWDFTYDGVPEENAKMLKETCKKINKPYKGKCVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA69</accession>
    <name>L0AA69_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-hydroxyacid dehydrogenase, 3-hydroxyisobutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232217.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0559"/>
    <dbReference type="EnsemblBacteria" id="AFZ70319">
        <property type="protein sequence ID" value="AFZ70319"/>
        <property type="gene ID" value="Calag_0559"/>
    </dbReference>
    <dbReference type="GeneID" id="14211819"/>
    <dbReference type="KEGG" id="clg:Calag_0559"/>
    <dbReference type="eggNOG" id="arCOG00247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_1_1_2"/>
    <dbReference type="OMA" id="IASIDCP"/>
    <dbReference type="OrthoDB" id="75486at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="159"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="284" mass="31591" checksum="16739F4DE0BF22B3" modified="2013-03-06" version="1">MKIGIIGLGRMGRGIAKNLVNKGYDVEGYDVDPTSYKILSNLKSFKPLNSISESKDSDFILLLLPTGKEVIEALKELVNYKGIIIDMTTMGYDELNDVINFINNNGLNYISAKIERGPSDAEAGRLIFYVGGRKDLVDKSDKLFKDMGEYIYLGSNENANIIKLISTLLLTANTVLLAEVSQIADKLRIDKDLLVKALSMGGADSIQLRSRFPMMINNSYKEIFSVKLSKYVAEKTLEYINDYGVTYSPLLKYVSDILKLSDALGIGNKDIAEISEFYKKINSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA90</accession>
    <name>L0AA90_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232720.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70823">
        <property type="protein sequence ID" value="AFZ70823"/>
        <property type="gene ID" value="Calag_1101"/>
    </dbReference>
    <dbReference type="GeneID" id="14212361"/>
    <dbReference type="KEGG" id="clg:Calag_1101"/>
    <dbReference type="eggNOG" id="arCOG13706">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1275257_0_0_2"/>
    <dbReference type="OMA" id="SEYIMIK"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="216" mass="24327" checksum="800042E8D03636ED" modified="2013-03-06" version="1">MEKNAKYIIIALVLALILTNVLWVISYTQMNASLNKYKHDLNQSLITLNNASKAIAYYQKTLNATEKLLNITTSLLSIYNKTLTLQVIQNKLIIYNNSMIEYKIAQTSFSVAVNLTLNSIQNPSKYNLTLASYYINITYQSLNQIKYNGMILGLPNNFTSNISNALSVVNSVNRIINNLSNGGKPTIGDITTLNNALTLYNYYLLSSEYIMIKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAB7</accession>
    <name>L0AAB7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type oligopeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0203"/>
    <dbReference type="EnsemblBacteria" id="AFZ69985">
        <property type="protein sequence ID" value="AFZ69985"/>
        <property type="gene ID" value="Calag_0203"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0203"/>
    <dbReference type="eggNOG" id="arCOG01533">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319962_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="385"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ69985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="941" mass="104335" checksum="95E3761A746D69A5" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAC0</accession>
    <name>L0AAC0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232713.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1094"/>
    <dbReference type="EnsemblBacteria" id="AFZ70816">
        <property type="protein sequence ID" value="AFZ70816"/>
        <property type="gene ID" value="Calag_1094"/>
    </dbReference>
    <dbReference type="GeneID" id="14212354"/>
    <dbReference type="KEGG" id="clg:Calag_1094"/>
    <dbReference type="eggNOG" id="arCOG07300">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2712595_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="72" mass="8399" checksum="8484195DD9F9FB31" modified="2013-03-06" version="1">MGRTTPSTRMVIEDEINRLLKILEYTNEDKDKAKEIIKEAYDLVSYYQFETLSDPLEPIVLGLILYIAKRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAE9</accession>
    <name>L0AAE9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Triosephosphate isomerase</fullName>
            <shortName evidence="2">TIM</shortName>
            <shortName evidence="2">TPI</shortName>
            <ecNumber evidence="2 3">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tpiA</name>
        <name evidence="4" type="ordered locus">Calag_1167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="2 3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1167"/>
    <dbReference type="EnsemblBacteria" id="AFZ70888">
        <property type="protein sequence ID" value="AFZ70888"/>
        <property type="gene ID" value="Calag_1167"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1167"/>
    <dbReference type="eggNOG" id="arCOG01087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104921_0_0_2"/>
    <dbReference type="OMA" id="IPVYAQH"/>
    <dbReference type="OrthoDB" id="60670at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_A">
        <property type="entry name" value="TIM_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022891">
        <property type="entry name" value="Triosephosphate_isomerase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="227" mass="24709" checksum="CE4DE32F4B203A08" modified="2013-03-06" version="1">MAIEMKYVFAINFKSYETAYNNVALEIAKTANQLSSKYSNVRIILSVPSVMISKIINIYDDIYLQHIDPLDYGAYTGFLSVDSLKYLEVKGSLINHSEHKIIYRDIEKIVKKMKELNKESLVCADTPGEAAGIAYLNPSMIAVEPPELIGSGIPVSKAKPEVITESLKAVKSVSNIPVLAGAGITIPDDAIKAIELGSSGVLIASAVMKSKNPNKVIIDFVEKMNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAG5</accession>
    <name>L0AAG5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1149"/>
    <dbReference type="EnsemblBacteria" id="AFZ70871">
        <property type="protein sequence ID" value="AFZ70871"/>
        <property type="gene ID" value="Calag_1149"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1149"/>
    <dbReference type="eggNOG" id="arCOG03851">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165897_0_0_2"/>
    <dbReference type="OMA" id="PFYFKSF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="117" mass="13462" checksum="B7FDCB0767A7016A" modified="2013-03-06" version="1">MNEHKEPFLFKSYERIIGIAHDVNELKSEMERLSKVDPGAVNYHLKEKHIVNWLNYIGEGELAKKLENVTDVNDALVLLKEEKSAKTEKPLSETQGHEPIKQKRRGGGRRKKSQSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAG9</accession>
    <name>L0AAG9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable porphobilinogen deaminase</fullName>
            <ecNumber evidence="3">2.5.1.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_1154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232773.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1154"/>
    <dbReference type="EnsemblBacteria" id="AFZ70876">
        <property type="protein sequence ID" value="AFZ70876"/>
        <property type="gene ID" value="Calag_1154"/>
    </dbReference>
    <dbReference type="GeneID" id="14212414"/>
    <dbReference type="KEGG" id="clg:Calag_1154"/>
    <dbReference type="eggNOG" id="arCOG04299">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_1_0_2"/>
    <dbReference type="OMA" id="LWQANHI"/>
    <dbReference type="OrthoDB" id="95523at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="3"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="223"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="299" mass="34003" checksum="D4ECCA81D111532D" modified="2013-03-06" version="1">MKLVISTRGSKLSLKQADLFENYIKNFLNVNIEKKIVKTKGDLILDKPLYEIGEKGLFEKEVNNAVLNGEADLAIHSMKDLPKDIDPRLDIIMVLPREIPNDSLVFSKYKVNDIMEIKENSIVGTSSIRRKSFLMHYNDKVIIKPLRGNIDTRIKKLENNEYDFIILAEAGIRRLNFNINRLLIPLELFPPEPGQGIIAVVGIKDNSIVKEISKYTDKNTYYMAVAEREFLNEAKANCNTPIGAVSIINQNKIMMIVGLASYDGSFMDIIRFKDELNNAKKLGKKAGQYVYSMLDKVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAH2</accession>
    <name>L0AAH2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232327.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0682"/>
    <dbReference type="EnsemblBacteria" id="AFZ70429">
        <property type="protein sequence ID" value="AFZ70429"/>
        <property type="gene ID" value="Calag_0682"/>
    </dbReference>
    <dbReference type="GeneID" id="14211942"/>
    <dbReference type="KEGG" id="clg:Calag_0682"/>
    <dbReference type="eggNOG" id="arCOG04333">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_2"/>
    <dbReference type="OMA" id="NDECYSE"/>
    <dbReference type="OrthoDB" id="32104at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="44"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="352" mass="40417" checksum="72E03CC21EE76FC8" modified="2013-03-06" version="1">MFDIYEFFSELSKNNVKIRMDAGDPDIKPNEIIIKELINNIRDLGYAPYKGLDELREIIADYHKVDINNVIITPGSKAAISSLILFSDKVNLISPYWSGYEFSANLFNKKIFVIKTNLEENWAPNFDNIERDSTLIINYPNNPTGKIINNNEIKKLIDISMDRNVKIISDEAYRDILFEGPKFKITDYIIENSVSIFSFSKTFSLPGLRLGYAVGDKNLINKMGEFIKANITSVPKFSQKAAIKAIENWDNIASYVKNIYYNRLEIFLNNIDKKKFDYMKPSGTFYVFLRLRENVSGTKLAYALARKGLGIFPGEAFGEDYTNFIRVSLTTNEKNIKEATKLINETVDEIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAI3</accession>
    <name>L0AAI3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative thioredoxin/glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232000.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0325"/>
    <dbReference type="EnsemblBacteria" id="AFZ70102">
        <property type="protein sequence ID" value="AFZ70102"/>
        <property type="gene ID" value="Calag_0325"/>
    </dbReference>
    <dbReference type="GeneID" id="14211585"/>
    <dbReference type="KEGG" id="clg:Calag_0325"/>
    <dbReference type="eggNOG" id="arCOG04235">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095574_0_0_2"/>
    <dbReference type="OMA" id="KMWLLAK"/>
    <dbReference type="OrthoDB" id="105723at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="250" mass="29141" checksum="9320ADAED738F3C0" modified="2013-03-06" version="1">MNTEIELYFHPTCATSHEIIMSLYEKGYLDNIKLHNTLAPLENNFIWSVPWLIVNKEPVGTDPITSEEIIEIIENKKIDINDPKESFMMSILHSSYASSISILHKDLQPVINNSFIKASIRYGFSNIELNEFKSQIIKIKENLFEEYRDKIRRALAVSFVRELYWSKSGKIDYNEIVNYSNEIIVGLWLLSKASIGRVGLISKPYIYGDIDIKEISEFVSKRGKGLLEKIKEEQDAIYNDKKYWEIIKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAI5</accession>
    <name>L0AAI5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Diphthine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232825.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1209"/>
    <dbReference type="EnsemblBacteria" id="AFZ70928">
        <property type="protein sequence ID" value="AFZ70928"/>
        <property type="gene ID" value="Calag_1209"/>
    </dbReference>
    <dbReference type="GeneID" id="14212469"/>
    <dbReference type="KEGG" id="clg:Calag_1209"/>
    <dbReference type="eggNOG" id="arCOG04161">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066040_0_0_2"/>
    <dbReference type="OMA" id="TAGDPMV"/>
    <dbReference type="OrthoDB" id="102360at2157"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004164">
        <property type="term" value="F:diphthine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="PTHR10882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="278" mass="31570" checksum="5601CBAB0C44D22A" modified="2013-03-06" version="1">MPLYLIGLNHEYITKKALEYIKSSDLIIIDSYTMPNSDKIVSDVLNIAKEKKVIIANRRMLEDESSDVLNIAKEKKVGIIIPGDPLIATTHASIVIDAKIKNIDVEIINGISGICMTKSLSGLQYYKYGKTLTIPGPWRNVKAYSLLFNLYANLCIKAHTLLLFDIDDNKKTLDASIGIKTILELNNELKLYSYLEKLLGILIHAGDKNMFIGNSLRNLLDDANIEEPYSLVIPSNLHSEEEKYLKYVLGIKSEALENHKKYIKEDFCKYMQYLSNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAI7</accession>
    <name>L0AAI7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232005.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0330"/>
    <dbReference type="EnsemblBacteria" id="AFZ70107">
        <property type="protein sequence ID" value="AFZ70107"/>
        <property type="gene ID" value="Calag_0330"/>
    </dbReference>
    <dbReference type="GeneID" id="14211590"/>
    <dbReference type="KEGG" id="clg:Calag_0330"/>
    <dbReference type="eggNOG" id="arCOG04051">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174522_0_0_2"/>
    <dbReference type="OMA" id="PHAQMAK"/>
    <dbReference type="OrthoDB" id="119555at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007355">
        <property type="entry name" value="DUF424"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04242">
        <property type="entry name" value="DUF424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="102" mass="11489" checksum="992372A1DE3F6ACF" modified="2013-03-06" version="1">MSYYINIINLETGEIMISMADKEIIGKKFEQRDGIVIDVDQNFYGSKLVDDEEALIYLKSADILILTGSKIVDMAIKEGIVNPDSVLEINGVKHVQVYKFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAL4</accession>
    <name>L0AAL4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal flagellin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1241"/>
    <dbReference type="EnsemblBacteria" id="AFZ70958">
        <property type="protein sequence ID" value="AFZ70958"/>
        <property type="gene ID" value="Calag_1241"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1241"/>
    <dbReference type="eggNOG" id="arCOG03871">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3245163_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="42" mass="4428" checksum="EA5818ABDFD684D2" modified="2013-03-06" version="1">MHYTIKGVGNGKGKKNSKTISDIVAVVMLILIAIAAAVLIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAL8</accession>
    <name>L0AAL8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">V-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_1207</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232823.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1207"/>
    <dbReference type="EnsemblBacteria" id="AFZ70926">
        <property type="protein sequence ID" value="AFZ70926"/>
        <property type="gene ID" value="Calag_1207"/>
    </dbReference>
    <dbReference type="GeneID" id="14212467"/>
    <dbReference type="KEGG" id="clg:Calag_1207"/>
    <dbReference type="eggNOG" id="arCOG04138">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025558_0_0_2"/>
    <dbReference type="OMA" id="MAVNIMA"/>
    <dbReference type="OrthoDB" id="14889at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="222"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="681" mass="76445" checksum="70249F43A90D3C9C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAL9</accession>
    <name>L0AAL9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1246"/>
    <dbReference type="EnsemblBacteria" id="AFZ70963">
        <property type="protein sequence ID" value="AFZ70963"/>
        <property type="gene ID" value="Calag_1246"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1246"/>
    <dbReference type="eggNOG" id="arCOG00773">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073524_0_0_2"/>
    <dbReference type="OMA" id="PTDVNWG"/>
    <dbReference type="OrthoDB" id="41742at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="2">
        <location>
            <begin position="175"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="336" mass="37954" checksum="71BE42AD6C9402DD" modified="2013-03-06" version="1" precursor="true">MACKRKLTPFETKLTTLFQVMPMHANPLGMLFGGVMEDWMIQVSNMEATRIAKRPTLLAGMDSIFFISPVLVGENANITAWVDYVGNTSIDIGLLVEAENPILNEKRLTTLAHMTYVAVGKDLRPVPLDVCIEPKTKEEEEIYQEALKRRKSRENRIKDRRTKALDSLPPKGLDDRFTITNYKVVMPEDAMALNTLFAGKLMRLLDESTALVGTRYARGPVVTASVDTTDFYSPVMVGETLIIYSTLTNIGKSSMEVIAKVVKRDEITGEEKHTTTSYFTLVHVGPTGRSEPLPEFKVTEEWQKQIIEESEKRRAERLEMLSSFKANAEKFRQIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAN4</accession>
    <name>L0AAN4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232843.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1229"/>
    <dbReference type="EnsemblBacteria" id="AFZ70946">
        <property type="protein sequence ID" value="AFZ70946"/>
        <property type="gene ID" value="Calag_1229"/>
    </dbReference>
    <dbReference type="GeneID" id="14212489"/>
    <dbReference type="KEGG" id="clg:Calag_1229"/>
    <dbReference type="eggNOG" id="arCOG14858">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2079302_0_0_2"/>
    <dbReference type="OMA" id="VIVYIAR"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="117" mass="13070" checksum="FEA74069EC29FC89" modified="2013-03-06" version="1">MEKELRIMMIILVSLGIMTGLILGITGIPMIDGLTVTIGFILYIVFGLIYPKSRFIFLGVMVGGDVGAIITLFSHPLVLPFVIIERGRGHSSIDIDFVQIIVFIEVIYYIITKKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAU7</accession>
    <name>L0AAU7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232038.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0364"/>
    <dbReference type="EnsemblBacteria" id="AFZ70140">
        <property type="protein sequence ID" value="AFZ70140"/>
        <property type="gene ID" value="Calag_0364"/>
    </dbReference>
    <dbReference type="GeneID" id="14211624"/>
    <dbReference type="KEGG" id="clg:Calag_0364"/>
    <dbReference type="eggNOG" id="arCOG01355">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011543_3_3_2"/>
    <dbReference type="OMA" id="PESYNWS"/>
    <dbReference type="OrthoDB" id="5945at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="194"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="499" mass="57348" checksum="887951B54C7A6ED6" modified="2013-03-06" version="1">MPDKIIEKELINKKYNKNMIKVALFYPSIYSVAMSSLVFHKLYFLLNQLDDIYLQRFYMPSLTGKPIPMRSFENGMPLKDFDYIFIPVHYELDYINIVKALIGSNIEIYSSKRNKPKIIIGGPTITANPEPLAELADIEVIGDLEAVWERIIDIIYGGNIDAGYGLYVPSLGKHEVRVAFSNYFDSLTKRILTNETTFTLAVEVMRGCPFNCLFCMESYISRPVRYKKSDDIINEVEELNKRYNDRISLIGLTVNSHPEFKNILKNINERKLNISLPSLRAELLDEESIELIAKLGQQSLTIAPESSERVRFALGKEIKDEDIIKVSKYASKFNLNIKAYFITSIPGETNDDLKSIIDLTYKIKKLGVKKIHLSVNPLIIKPRTPLQWLPMSDENAMKIKINYLKRNSNYDDFTTYDPLLALVQASISLSDRDVLKYLIQMAIEGGNRSSYRNALKNGLSDIALKGRSEPFPWDHIKDIINNEYLKERYIAFKEKMGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAV2</accession>
    <name>L0AAV2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl11</name>
        <name evidence="8" type="ordered locus">Calag_1297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232908.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1297"/>
    <dbReference type="EnsemblBacteria" id="AFZ71011">
        <property type="protein sequence ID" value="AFZ71011"/>
        <property type="gene ID" value="Calag_1297"/>
    </dbReference>
    <dbReference type="GeneID" id="14212557"/>
    <dbReference type="KEGG" id="clg:Calag_1297"/>
    <dbReference type="eggNOG" id="arCOG04372">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_4_0_2"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="98187at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="7">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="6">
        <location>
            <begin position="71"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="168" mass="18364" checksum="02DB08BA21ADDC33" modified="2013-03-06" version="1">MPQEKVLTIQVEGGAAKPGPPLGPTLSSLGLNVKKVVDEINEKTKDFKGMTIPVKITINMSTKEYKIEVGIPTITTLLLREAGASEPSGDPEHKKVGDLKLEKVVEIAVRSRPKLLSKNLENAVKSILGSAKSIGLTVEGKNPKDVIKEIEDGKHKELLEKYENEYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAW3</accession>
    <name>L0AAW3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232918.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1309"/>
    <dbReference type="EnsemblBacteria" id="AFZ71021">
        <property type="protein sequence ID" value="AFZ71021"/>
        <property type="gene ID" value="Calag_1309"/>
    </dbReference>
    <dbReference type="GeneID" id="14212569"/>
    <dbReference type="KEGG" id="clg:Calag_1309"/>
    <dbReference type="eggNOG" id="arCOG06044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_5_1_2"/>
    <dbReference type="OMA" id="HIGASKR"/>
    <dbReference type="OrthoDB" id="64337at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="221" mass="25411" checksum="572BB8A6074355D3" modified="2013-03-06" version="1">MSENEDKQSKYSDIVYDLLKKDILNRRFEPKDKLSETALSKLYNVSRTPVREALHKLEKEGLVVKLSDGYHVSFLTKEQILKLFEVRSILEGLAAEKAAMNRDPELLKKLRDAAEEFKKINKNDPLAAAHANANFHDIIADLSGNEYLRDILKDIRNKLAIVRIDLFASTSRIDQEIEEHWKIYQAIEKGDPQEARKAALEHQNNLIEFIKSKKMIGGLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAW4</accession>
    <name>L0AAW4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromatin protein Cren7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">creN7</name>
        <name evidence="3" type="ordered locus">Calag_0502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="2">Methylated at multiple sites, to varying extents.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Cren7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0502"/>
    <dbReference type="EnsemblBacteria" id="AFZ70267">
        <property type="protein sequence ID" value="AFZ70267"/>
        <property type="gene ID" value="Calag_0502"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0502"/>
    <dbReference type="eggNOG" id="arCOG04114">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2911298_0_0_2"/>
    <dbReference type="OMA" id="LAPEKAW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01387">
        <property type="entry name" value="Chromatin_Cren7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038647">
        <property type="entry name" value="Cren7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020906">
        <property type="entry name" value="dsDNA-bd_Cren7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11520">
        <property type="entry name" value="Cren7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="61" mass="6858" checksum="B223F8349ACCA22A" modified="2013-03-06" version="1">MMPEKFPPVKVKDPSSGKEVELSPIKVWTLAPKSRKGVKIGLFKSPETGKFFRAKVPENYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAW5</accession>
    <name>L0AAW5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF126 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232456.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0818"/>
    <dbReference type="EnsemblBacteria" id="AFZ70559">
        <property type="protein sequence ID" value="AFZ70559"/>
        <property type="gene ID" value="Calag_0818"/>
    </dbReference>
    <dbReference type="GeneID" id="14212078"/>
    <dbReference type="KEGG" id="clg:Calag_0818"/>
    <dbReference type="eggNOG" id="arCOG04279">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141583_2_0_2"/>
    <dbReference type="OMA" id="CEPIVAT"/>
    <dbReference type="OrthoDB" id="108624at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01356">
        <property type="entry name" value="AcnX_swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012016">
        <property type="entry name" value="AcnX_sub2_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002840">
        <property type="entry name" value="AcnX_swivel_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01989">
        <property type="entry name" value="DUF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004966">
        <property type="entry name" value="UCP004966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF126" evidence="1">
        <location>
            <begin position="24"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="126" mass="13664" checksum="47FD56262A4D45C9" modified="2013-03-06" version="1">MREITGRALIKGEAEGEALVIQEISFYGDINPNNGNLVDGRNVKDKILVAYKPRGSTVGSYIIYALKENGFAPKAIIMAKSEPIIIAGCALSNIPLIDNIDINVLKDIKDGDKIIVKGNKIILLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAX9</accession>
    <name>L0AAX9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1359"/>
    <dbReference type="EnsemblBacteria" id="AFZ71068">
        <property type="protein sequence ID" value="AFZ71068"/>
        <property type="gene ID" value="Calag_1359"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1359"/>
    <dbReference type="eggNOG" id="arCOG03664">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_759923_0_0_2"/>
    <dbReference type="OMA" id="LYEIPYY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019187">
        <property type="term" value="F:beta-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="PTHR16779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="147"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="391" mass="44675" checksum="DE12A2440D6DFD1F" modified="2013-03-06" version="1">MTIENIIQAVKTTELAANNAFSSSPYLKYAVAADWTAISAYAIVLIITLTIYNSKKEKERANNVALVIVSIASKKVKNVLYKNINHHKKLKIPMYLVIDEGAELQEDLSKLSGINLVIVPKSFRKDLFGKGRALRYFVENFVKPDFWYVFLDDDNLILNNSFLYEIPYYEKKGYVAFNPVLLPRKGKSYMAYIMDFARYLDDISFFRLFTGLVKKPYVGLHGELLGVKGSFLLEVNAFNKPSKVEDFLFSIDVVKNSGKTWQSNTKVSILSPNSIKDLIKQRARWYSGMMEDSKYAPITMRIIIAFKTFARTLGLIGLWILLPFVNYYIVALILIPSSLVYWVVYIYGVKKSGKLRYIVTLPIFGLLEGLGLIYGLTRIGKREFIIIDKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAY4</accession>
    <name>L0AAY4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232970.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1364"/>
    <dbReference type="EnsemblBacteria" id="AFZ71073">
        <property type="protein sequence ID" value="AFZ71073"/>
        <property type="gene ID" value="Calag_1364"/>
    </dbReference>
    <dbReference type="GeneID" id="14212624"/>
    <dbReference type="KEGG" id="clg:Calag_1364"/>
    <dbReference type="eggNOG" id="arCOG04181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062565_0_0_2"/>
    <dbReference type="OMA" id="YGVPLYA"/>
    <dbReference type="OrthoDB" id="66021at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009995">
        <property type="entry name" value="DUF1512"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07431">
        <property type="entry name" value="DUF1512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016495">
        <property type="entry name" value="UCP016495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="371" mass="41297" checksum="2332FE505A337E27" modified="2013-03-06" version="1">MVGITAIENWVYLLINVVWVLIFVLYLFGFGNYLQVYWWKADIKNKLAILNDMANTARNKTIEFMNKNKAKDASRTLDRLIDFFAIDPVNIEPTDIINRLRHIVNLRDTKFKQTFEISMPESNEVARSIASTAAEISSALFLIYKYVQHILLSSDKTKNWYMIMYLSLMMPQIMQIASIYRKALDDFLEGVPVGDGAGPIVALKLSNYKNDWREIDEDTVATETEYNGRKIILVKAKGPGSTVGRPGEATAKIIKEALAKGEKVSLLITVDAALKFEGEETGSVAEGVGAAIGDPGPEKIMFERIATEYNIPLRAVIIKMGMEEAIMAMDKKILDGTDKAVERVKQIMEEESKPGETVVIAGIGNTSGVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAZ0</accession>
    <name>L0AAZ0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1369"/>
    <dbReference type="EnsemblBacteria" id="AFZ71078">
        <property type="protein sequence ID" value="AFZ71078"/>
        <property type="gene ID" value="Calag_1369"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1369"/>
    <dbReference type="HOGENOM" id="CLU_2597507_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="79" mass="9375" checksum="991846AF68B174C6" modified="2013-03-06" version="1">MMTWATNEGEDEIPSLTLTANMFIYKLKNNLILFKIFYFKLKTVIKSKILYLLLNLFYTDSINLVGLIWMRCMICQVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB07</accession>
    <name>L0AB07_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="7">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">leuS</name>
        <name evidence="12" type="ordered locus">Calag_0458</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="7"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232123.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0458"/>
    <dbReference type="EnsemblBacteria" id="AFZ70225">
        <property type="protein sequence ID" value="AFZ70225"/>
        <property type="gene ID" value="Calag_0458"/>
    </dbReference>
    <dbReference type="GeneID" id="14211718"/>
    <dbReference type="KEGG" id="clg:Calag_0458"/>
    <dbReference type="eggNOG" id="arCOG00809">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004174_0_0_2"/>
    <dbReference type="OMA" id="AWNMAFQ"/>
    <dbReference type="OrthoDB" id="4914at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_A">
        <property type="entry name" value="Leu_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020791">
        <property type="entry name" value="Leu-tRNA-lgase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="PTHR45794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1g" evidence="11">
        <location>
            <begin position="595"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="714"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="639"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="956" mass="112118" checksum="9BBF043CCD08E672" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB18</accession>
    <name>L0AB18_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor S, archaeal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_1367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1367"/>
    <dbReference type="EnsemblBacteria" id="AFZ71076">
        <property type="protein sequence ID" value="AFZ71076"/>
        <property type="gene ID" value="Calag_1367"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1367"/>
    <dbReference type="eggNOG" id="arCOG00579">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_3_0_2"/>
    <dbReference type="OMA" id="MVKFCPK"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="DNA-dir_RNA_pol_M/15kDasu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006288">
        <property type="entry name" value="TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="PTHR11239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="TFIIS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01384">
        <property type="entry name" value="TFS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="8">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ71076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="124" mass="14016" checksum="DE34FE4FA62E189C" modified="2013-03-06" version="1">MIKMVQGSMMFCPKCGSLMKPKHIGGKLYLVCPKCGYKTEVDQNSLSNTLKVKEKIQHTPKDKTIVVDSQAPPPTAQIVKGSIRCPRCGNDELLAWMIQTRAADEPPTRFYRCTKCGYTWREYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB25</accession>
    <name>L0AB25_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaredoxin-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232990.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1384"/>
    <dbReference type="EnsemblBacteria" id="AFZ71093">
        <property type="protein sequence ID" value="AFZ71093"/>
        <property type="gene ID" value="Calag_1384"/>
    </dbReference>
    <dbReference type="GeneID" id="14212644"/>
    <dbReference type="KEGG" id="clg:Calag_1384"/>
    <dbReference type="eggNOG" id="arCOG01218">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082677_0_0_2"/>
    <dbReference type="OMA" id="RMAHKFA"/>
    <dbReference type="OrthoDB" id="67467at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011903">
        <property type="entry name" value="Glutaredoxin-like_bact/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02187">
        <property type="entry name" value="GlrX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="30"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="144"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ71093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="245" mass="27552" checksum="7441500F552594BC" modified="2013-03-06" version="1">MAGRYYDIEFDESFINELRETLAYMVNPVTINIFIDDNCETCEDTIKLIKTIQDASPIKNGKKMIEVKIYNKNNPEDLKEFEKQGVERVPAVTLINGLIKYSGIPAGEEIRGFIETIMRISENDSGLEKETREELAKLNGKVHIETVITPSCPYCPYAVLLANMFAYEAYKQNNPKILSETVEAYENMDIAEKYGVMSVPAIALNGVMSFVGVPYEEDFVSYIKAAAENKLKQMAPKEEGEATGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB32</accession>
    <name>L0AB32_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">K+-transporting ATPase, c chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Calag_0874</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232511.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0874"/>
    <dbReference type="EnsemblBacteria" id="AFZ70614">
        <property type="protein sequence ID" value="AFZ70614"/>
        <property type="gene ID" value="Calag_0874"/>
    </dbReference>
    <dbReference type="GeneID" id="14212134"/>
    <dbReference type="KEGG" id="clg:Calag_0874"/>
    <dbReference type="eggNOG" id="arCOG04805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138948_0_0_2"/>
    <dbReference type="OMA" id="VSHAIAP"/>
    <dbReference type="OrthoDB" id="103779at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="158" mass="17853" checksum="0E8C2C8A04547688" modified="2013-03-06" version="1">MNVRQYLLIPLAIFVFSILILGFVYPLMLNGIGLIAKNNAEGSLIIINGTIIGSYLIAGKINNSAFFWANYNNSFVSGYDPYITVNQALSQVNRISNSTGISKQFLINIIYENSEQIEEQDLFIFSPGQRVVNVMELNAILIRKYPNIYDKYLKLNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB56</accession>
    <name>L0AB56_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1382</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232988.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1382"/>
    <dbReference type="EnsemblBacteria" id="AFZ71091">
        <property type="protein sequence ID" value="AFZ71091"/>
        <property type="gene ID" value="Calag_1382"/>
    </dbReference>
    <dbReference type="GeneID" id="14212642"/>
    <dbReference type="KEGG" id="clg:Calag_1382"/>
    <dbReference type="eggNOG" id="arCOG04091">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_1_1_2"/>
    <dbReference type="OMA" id="LPAKNFG"/>
    <dbReference type="OrthoDB" id="91154at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="131" mass="14728" checksum="630B5BB7DC87E974" modified="2013-03-06" version="1">MVDVLSGHLSSIMNAELRGEREVILMPASKLSASVLKVLQKEGYIGEFEYIDDGRFGKFKIQLLGRINKIGTVRPRVSIKYNELLRLPENLRRFLASRDLGHLIISTNQGVMTHKDALVKKTGGIVIAYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB60</accession>
    <name>L0AB60_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="3">MTA phosphorylase</shortName>
            <shortName evidence="3">MTAP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mtnP</name>
        <name evidence="5" type="ordered locus">Calag_0627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0627"/>
    <dbReference type="EnsemblBacteria" id="AFZ70382">
        <property type="protein sequence ID" value="AFZ70382"/>
        <property type="gene ID" value="Calag_0627"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0627"/>
    <dbReference type="eggNOG" id="arCOG01327">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_0_2_2"/>
    <dbReference type="OMA" id="ADPFCPE"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="4">
        <location>
            <begin position="19"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="3">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="3">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="223"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="279" mass="31237" checksum="50E810A51490F855" modified="2013-03-06" version="1">MVNRLGITLTVPKDVKAHVGIIGGSGLYKADIIENPKEVKVFTPYGEPSDYITVGEIKGVKVAFLPRHGKGHRYPPHKVNYRANIWALKSLGIKHVISVSAVGSLNENMKPGDFVIPDQFIDMTKLRNYTFFDGPTTVHVSMADPFCKYLSKKLYESSKSLGYTSHFGGTYICIEGPRFSTRAESRVWKEVFKADIIGMTLVPEVNLACEAQLCYSTLAMVTDYDVWAEKPVTAVEVERVMNQNIERARKILYDVIPKLSENPIEEECSCCKALEHAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB94</accession>
    <name>L0AB94_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ERCC4-type nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1424"/>
    <dbReference type="EnsemblBacteria" id="AFZ71131">
        <property type="protein sequence ID" value="AFZ71131"/>
        <property type="gene ID" value="Calag_1424"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1424"/>
    <dbReference type="eggNOG" id="arCOG04206">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101253_0_0_2"/>
    <dbReference type="OMA" id="IIEGDLW"/>
    <dbReference type="OrthoDB" id="72352at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="2">
        <location>
            <begin position="17"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="243" mass="28171" checksum="A15598B3A5BE42A5" modified="2013-03-06" version="1">MVYAKKVDRVMETKKYRVYADSREEASGVPKILESLGLMVIRRQLEEGDYLIPDNIIIERKSSNDFVKSLFDGRLFEQAKKMSSKYNNIIYIVEGDFRKSLLFYKNREKQIQSALISLVLEYKVKVLWSLDQLSTAEYIESIARKSEPSKEVNESPILKKPKINDNRQWQLYILQSFPGIGEKSAEKILEHFGSLEKFFNSSLSELANIIGEKKASKIKELIKLPYKKDAKGNSSLENYYSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABC4</accession>
    <name>L0ABC4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type anion transport system, duplicated permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0692</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232335.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0692"/>
    <dbReference type="EnsemblBacteria" id="AFZ70437">
        <property type="protein sequence ID" value="AFZ70437"/>
        <property type="gene ID" value="Calag_0692"/>
    </dbReference>
    <dbReference type="GeneID" id="14211952"/>
    <dbReference type="KEGG" id="clg:Calag_0692"/>
    <dbReference type="eggNOG" id="arCOG00174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036171_2_0_2"/>
    <dbReference type="OMA" id="FGTQWYI"/>
    <dbReference type="OrthoDB" id="71481at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="11"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="326"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="545" mass="62684" checksum="E4AEE134D4C14E3B" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABE1</accession>
    <name>L0ABE1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232268.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0614"/>
    <dbReference type="EnsemblBacteria" id="AFZ70370">
        <property type="protein sequence ID" value="AFZ70370"/>
        <property type="gene ID" value="Calag_0614"/>
    </dbReference>
    <dbReference type="GeneID" id="14211874"/>
    <dbReference type="KEGG" id="clg:Calag_0614"/>
    <dbReference type="eggNOG" id="arCOG01681">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_5_3_2"/>
    <dbReference type="OMA" id="MCVCELE"/>
    <dbReference type="OrthoDB" id="111287at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="123" mass="13972" checksum="90246084BD2983DB" modified="2013-03-06" version="1">MSNLSINKNDPILIELESFFSALSDKTRLEIVFYLLEKNVGTVQEIANGINKNQSLVSHHLSCLKNCGVVKLEKKGKFSLYEINGDNVKKIIKFAINHVESYSKSILSCDIIKEEKKEEEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-12-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABF9</accession>
    <name>L0ABF9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrous oxidase accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ71233">
        <property type="protein sequence ID" value="AFZ71233"/>
        <property type="gene ID" value="Calag_1534"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1534"/>
    <dbReference type="eggNOG" id="arCOG02553">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1028965_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NosD" evidence="1">
        <location>
            <begin position="3"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="270" mass="30077" checksum="345F21DEBE7AE6C4" modified="2013-03-06" version="1">MLNGANSIFINNGNTITISEVSLTYSYSGINLANSLSAIIYLVKSIVNGNTTKGSIYAYPNITNLKIFETLSIGGLYGILSGAYNSLIYNNTIENSHYGIIAGLGKNITIFMNYVKNNTIGILSGYSTNLSIFSDEIIGNKNGIELTKISHAFIYLNYFNNSKNVNISNSNVTYNTKTKVNYEFNGNNFTNYLGNYWYGYKGSEIDSEGIGSKPYNTTYGLDNYPLTSIPSPSIRHFNNSSYPTTDYSNDKHSNKFNDFFNNFFDKHSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABG8</accession>
    <name>L0ABG8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyr_redox_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232293.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0640"/>
    <dbReference type="EnsemblBacteria" id="AFZ70395">
        <property type="protein sequence ID" value="AFZ70395"/>
        <property type="gene ID" value="Calag_0640"/>
    </dbReference>
    <dbReference type="GeneID" id="14211900"/>
    <dbReference type="KEGG" id="clg:Calag_0640"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_0_1_2"/>
    <dbReference type="OMA" id="IGVHMDR"/>
    <dbReference type="OrthoDB" id="115808at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="377" mass="42471" checksum="3FAB21327692A38C" modified="2013-03-06" version="1">MKIAVIGAGFAGLIISNYMLKANIDVDLYEEHSKTGIPEHCTGIVSSLTSKLIGNVSKKNILKEFKGVNIKSYGNSAKLYTKEPIIKLDRVKLENDLLNNFIDKGGKVFLKSRIYNLDDINEKNYDAIIISDGVNGFLHKKYGLGFSGRLIYGINQEFCLDDYKSNFDVVFDNITSHNFFSWYVPLGNKVIVGTGAEDPKRLVIAQQNAIKYFNIKSKPCNTYGGLIISGINKVEFRKNKLIAMGDNIGLTKPLTGGGLFPNSLTAYLAYSLINKGFNILDSLEFSISYVLRILKKTNNLSIYLHKNPEIVRELIEISKRTDILKNLNGEIDYDLHNDIISKTFKNKDSYKFLLYFMANNPKAFFTLGNNLLKDFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABH9</accession>
    <name>L0ABH9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233113.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1516"/>
    <dbReference type="EnsemblBacteria" id="AFZ71216">
        <property type="protein sequence ID" value="AFZ71216"/>
        <property type="gene ID" value="Calag_1516"/>
    </dbReference>
    <dbReference type="GeneID" id="14212777"/>
    <dbReference type="KEGG" id="clg:Calag_1516"/>
    <dbReference type="eggNOG" id="arCOG07234">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2091182_0_0_2"/>
    <dbReference type="OMA" id="YLIYPID"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="116" mass="12828" checksum="3AF862960CC5BE38" modified="2013-03-06" version="1" precursor="true">MRKINIAIILIGIILTLIFSYFIPYVWGGIIPGAIIGVIKRRSTKLISSFLIGFIGSLVVYFVYPINYLISLAKTVELLAGIQWFILILLFPLLYGLIELSAAGIVGEILSLISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABI6</accession>
    <name>L0ABI6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233118.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1521"/>
    <dbReference type="EnsemblBacteria" id="AFZ71221">
        <property type="protein sequence ID" value="AFZ71221"/>
        <property type="gene ID" value="Calag_1521"/>
    </dbReference>
    <dbReference type="GeneID" id="14212782"/>
    <dbReference type="KEGG" id="clg:Calag_1521"/>
    <dbReference type="eggNOG" id="arCOG02835">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070738_1_0_2"/>
    <dbReference type="OMA" id="PFGKYYY"/>
    <dbReference type="OrthoDB" id="77334at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007354">
        <property type="entry name" value="CruF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39419">
        <property type="entry name" value="PTHR39419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04240">
        <property type="entry name" value="Caroten_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="237" mass="27174" checksum="F87E146CC0C9D5C9" modified="2013-03-06" version="1">MIKLKEIPWLILLIYPISMVMSLQKLPLIIIIITSILSSIFVLIALYLIISYEEIGLKNTIKFLIISYVVSYIFEFLGVRYGIPFGKYYYNPKGLGPLLFGVPLFIPFLWASLGFFSLAVSNWLLAVLGMVTLDIAFDPLLSYKAKLWVWITKGDYYGVPITNFIGWAIVSFIFYAIYKINKGKSPKKSVYSVSFYIEYLVSWIILDFIKGLWLAGLLGILMGFLFMYLSFFTGIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABJ5</accession>
    <name>L0ABJ5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase/AMP-acid ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232399.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0758"/>
    <dbReference type="EnsemblBacteria" id="AFZ70502">
        <property type="protein sequence ID" value="AFZ70502"/>
        <property type="gene ID" value="Calag_0758"/>
    </dbReference>
    <dbReference type="GeneID" id="14212018"/>
    <dbReference type="KEGG" id="clg:Calag_0758"/>
    <dbReference type="eggNOG" id="arCOG01529">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_2"/>
    <dbReference type="OMA" id="GTFELES"/>
    <dbReference type="OrthoDB" id="3223at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="85"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="536"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="656" mass="74421" checksum="DB8896DB65CD277B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABL3</accession>
    <name>L0ABL3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0775"/>
    <dbReference type="EnsemblBacteria" id="AFZ70517">
        <property type="protein sequence ID" value="AFZ70517"/>
        <property type="gene ID" value="Calag_0775"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0775"/>
    <dbReference type="eggNOG" id="arCOG02793">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055959_0_0_2"/>
    <dbReference type="OMA" id="FFGELGW"/>
    <dbReference type="OrthoDB" id="77093at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="410" mass="45980" checksum="4A79246997FD7CF3" modified="2013-03-06" version="1">MENFTEIDKKSKINKYQWIAIISASITMFIWGFLLALAPIATQWPFVPPSDYTYLLVAAPTSLLIGNLVLGRYTDKFGRKKLFIIDMILFAISIPLILLSNNVVELGLGIGMAEFSLGGDETTVLTYLSEISPKNHRGKIIVGVTNIANFGALIAALLSIVTSFSIYIQRLSFGILLALSIPVIVITRALIPESFRWEYYKNVVKETKVEISKRDYTIRLYFLVSMAITIVLTYALMALIIGPYLFPRLTSWIIFIYNLGETIGGIILIPFVDSFSRKIIAFIAYLGGSFTMALFIPQFLFARSIIAIFMALLFLNGLFGELGWAFRVIFEPELFPTNIRATGIGLVRAIAYSLYVGSIFLTSGFSEFTYIFYNLGLWLFGLSGATLWLKYGIETKKKSLEDISDIIKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABL4</accession>
    <name>L0ABL4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1092"/>
    <dbReference type="EnsemblBacteria" id="AFZ70814">
        <property type="protein sequence ID" value="AFZ70814"/>
        <property type="gene ID" value="Calag_1092"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1092"/>
    <dbReference type="eggNOG" id="arCOG00062">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_890259_0_0_2"/>
    <dbReference type="OMA" id="NEKKMRS"/>
    <dbReference type="OrthoDB" id="66517at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="308" mass="34747" checksum="79BE3F7EE660833F" modified="2013-03-06" version="1">MAIIHTRIKLGARRTNMKRLEELINRLIIEHEDIDLIYLPAYPLTGPIVGYYPNQKVKNILKNFAERLNGSEIQQNQTFMIVSKWSHEFGIYIIAGPIVERAGPRLYLTTFMSNPLGELAGKYRKIAITRSEEENGLTPGKTVEVFNIKKKNAYVGVFTDEDLGYPEIFKALSFIGANVIIGSMLPYESRFFKMKSESGTSMLTLDLESINNFLSVRSKETDLPVILVGGAVEGVNNSGYVAFMPTITSEPEIGVVKEKIISYDDIDLPIIVEVDTSTKPVQYDEISKLILKNLCRRNELNEKESDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABL7</accession>
    <name>L0ABL7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232338.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0695"/>
    <dbReference type="EnsemblBacteria" id="AFZ70440">
        <property type="protein sequence ID" value="AFZ70440"/>
        <property type="gene ID" value="Calag_0695"/>
    </dbReference>
    <dbReference type="GeneID" id="14211955"/>
    <dbReference type="KEGG" id="clg:Calag_0695"/>
    <dbReference type="eggNOG" id="arCOG01080">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101758_3_0_2"/>
    <dbReference type="OMA" id="WLYPGGH"/>
    <dbReference type="OrthoDB" id="113704at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="141" mass="16275" checksum="783A03E1D0EFB003" modified="2013-03-06" version="1">MVAGGILIVNEEVLLVYHEKLKKWLYPGGHVEINETPREAAIREFKEETGLDVEVYGEKNNLSTDEATEEPKPLAIMNEIVKYPNETHIHYDLIFLVKLKGGTLINGKWFKREEIDKIDTYSNVKKILKHAFSFNNNFILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABT8</accession>
    <name>L0ABT8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps5</name>
        <name evidence="8" type="ordered locus">Calag_1173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts protein S4.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 6">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232791.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1173"/>
    <dbReference type="EnsemblBacteria" id="AFZ70894">
        <property type="protein sequence ID" value="AFZ70894"/>
        <property type="gene ID" value="Calag_1173"/>
    </dbReference>
    <dbReference type="GeneID" id="14212433"/>
    <dbReference type="KEGG" id="clg:Calag_1173"/>
    <dbReference type="eggNOG" id="arCOG04087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_0_1_2"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="OrthoDB" id="60954at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_A">
        <property type="entry name" value="Ribosomal_S5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_S5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="7">
        <location>
            <begin position="51"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="209" mass="22986" checksum="8EF45283E3433640" modified="2013-03-06" version="1">MSSTQVLESWEPKTQVGKLVKEGKITSIDEIFKRNMPILEPEIIDALLPDLQVEIIDVTLVQKMTDAGRVSRYRATVAVGNKNGYVGVGKSKAKQFRDSIDKAIRNAKLNITPIRRGCGSWECTCGEPHSVPYSVVGKSGSVVILLKPAPKGTGLVAGDVAKKVLTLAGIRDVWTKTFGETRTSYNFARATYMALRNTFKAVTPMDWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABU0</accession>
    <name>L0ABU0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232412.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70515">
        <property type="protein sequence ID" value="AFZ70515"/>
        <property type="gene ID" value="Calag_0772"/>
    </dbReference>
    <dbReference type="GeneID" id="14212032"/>
    <dbReference type="KEGG" id="clg:Calag_0772"/>
    <dbReference type="HOGENOM" id="CLU_2230248_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="105" mass="11786" checksum="85D410088ECFEF32" modified="2013-03-06" version="1">MNIGRDDKSYALLILDASRYLNQAATYLNTIISKDDTGNLIVTRASLKGLSMQVTRLSKNGCDMIEIQKIINRVQKLIDQLPPIPQVMQYAELAKENLIKAIAYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABV5</accession>
    <name>L0ABV5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0788"/>
    <dbReference type="EnsemblBacteria" id="AFZ70530">
        <property type="protein sequence ID" value="AFZ70530"/>
        <property type="gene ID" value="Calag_0788"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0788"/>
    <dbReference type="eggNOG" id="arCOG01130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_2"/>
    <dbReference type="OMA" id="ARFRHFS"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="40"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="407" mass="46009" checksum="36EFCD6759BF7F22" modified="2013-03-06" version="1">MTRMSINPPVMDMQPNVYLIEGESAFSYLPIIRKLQNQGKKVISFGIGQPDFPTPDHIKNAAKAALDDNFTGYTETQGIPELREAVANYLNSRYGSDVKSEEVIVTPGSKTAIFMAAAAYIRQNDEAIIIEPSYYAYAQVVKLFGGIPKFVSLDFDPNKGFSLNVEKIEKQITNHTRMIFVNNPHNPTGAVFSRDQLDQLVELARKKNIILVADEIYDNLIYRGSFKSLISYSEWRDNLLYINGFSKTFSMTGWRLAYLVARKELMPRFNDLAVSLYSCATSFVQKAGVIALNGDWTPVKNMAEEFNRRAQVLYTILKNAEGFEPYLPQGAFYMFPRISSILRKTNLTVKEFVNLLLEKAGVLVLPGDAFPDKAGKEFVRFSYATSMESIKEGAERIVEFTKDIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABW1</accession>
    <name>L0ABW1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232432.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70535">
        <property type="protein sequence ID" value="AFZ70535"/>
        <property type="gene ID" value="Calag_0794"/>
    </dbReference>
    <dbReference type="GeneID" id="14212054"/>
    <dbReference type="KEGG" id="clg:Calag_0794"/>
    <dbReference type="eggNOG" id="arCOG01390">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038143_1_0_2"/>
    <dbReference type="OMA" id="YLLMTVD"/>
    <dbReference type="OrthoDB" id="46196at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="45"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="374" mass="42961" checksum="6594ABD996770D5D" modified="2013-03-06" version="1">MIIFQGILSILLIGIIIITLLGIRSLNRSMKSFREFNGVGKRGVTVVMAARNEQNKIGKTLESLVKVDDKLEKIIVVNDRSTDNTREIIKKYMEIDKRIELLDIDKVPKSWVAKSYALYNGVKRAKYNNALLFLDADIEGDMQRIVNVASNIKEGELYTFMPYFETDNVISNSSQSFLSALLHGYFGYDRSVNKNSNYSLMFGCCWSIMPYTYYEVGGHASVKSDLMEDKNFATRAKSMGVNIIPIDGRDFIKTKSWNNVDDIKGLLSRIFFDYEKNLSNPINIYLLAIGLILLFYLPLIWIPLILIKQYLLSFISFMTYMIENIFFYLGGLTNKIKKPYSLLYFIPAYLLITGFIEAKRKGVIWKGETYKINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC13</accession>
    <name>L0AC13_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232482.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70585">
        <property type="protein sequence ID" value="AFZ70585"/>
        <property type="gene ID" value="Calag_0844"/>
    </dbReference>
    <dbReference type="GeneID" id="14212104"/>
    <dbReference type="KEGG" id="clg:Calag_0844"/>
    <dbReference type="HOGENOM" id="CLU_1639881_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="161" mass="17683" checksum="B07C303B8680729C" modified="2013-03-06" version="1" precursor="true">MPNARRLFTIGIVIIAVAIILLFLVSPYVLQYTFSNSIREAQRQINSTVYLLLPNQSLSIEISSGKILVYNATNPLKLLLNNQTLAQAGYNGTWIAPSTTNGTISLINNYTNQLKIGYAVVGIILWPSYLSIILGFLLGLVGIVVIAYATLVSLRNRAKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC16</accession>
    <name>L0AC16_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232559.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0931"/>
    <dbReference type="EnsemblBacteria" id="AFZ70662">
        <property type="protein sequence ID" value="AFZ70662"/>
        <property type="gene ID" value="Calag_0931"/>
    </dbReference>
    <dbReference type="GeneID" id="14212191"/>
    <dbReference type="KEGG" id="clg:Calag_0931"/>
    <dbReference type="HOGENOM" id="CLU_2519578_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="84" mass="9322" checksum="629D4DA8DB7C223F" modified="2013-03-06" version="1" precursor="true">MDRSNKFILTISILISLSFISLAFLNVNELGPYIGLYALIYLVSYRIIAPRAKKNYIGIALLLLFISIALLEVLSLIGIPVPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC45</accession>
    <name>L0AC45_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232492.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0854"/>
    <dbReference type="EnsemblBacteria" id="AFZ70595">
        <property type="protein sequence ID" value="AFZ70595"/>
        <property type="gene ID" value="Calag_0854"/>
    </dbReference>
    <dbReference type="GeneID" id="14212114"/>
    <dbReference type="KEGG" id="clg:Calag_0854"/>
    <dbReference type="eggNOG" id="arCOG01471">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095978_2_0_2"/>
    <dbReference type="OMA" id="ISCHFAK"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="169" mass="19938" checksum="63864F76D850B64E" modified="2013-03-06" version="1">MIAVTIELQDEHDFISRVNSFIKNYDINNEDLNKLNSLLKILKEFVGNCHHKKEEIFIFPYLINKGGDEASLANKMIDEHRIIENLESQLELNINKRNFNDTKNILNDLTSILDSHIQEENTVVFSYAEFIIDDTTKEKLIREMSQYENNTYYCNKEKYENILQSIVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC62</accession>
    <name>L0AC62_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type transport system involved in Fe-S cluster assembly, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0875"/>
    <dbReference type="EnsemblBacteria" id="AFZ70615">
        <property type="protein sequence ID" value="AFZ70615"/>
        <property type="gene ID" value="Calag_0875"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0875"/>
    <dbReference type="eggNOG" id="arCOG01715">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736928_0_0_2"/>
    <dbReference type="OMA" id="MSHHRED"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="368" mass="41717" checksum="2552EE472C755366" modified="2013-03-06" version="1">MIILSSITVDINKLNKIKWQDIGDSPTTKYYTDWNQYEKILKNQSEATFKIPEGKFDYIVGKCGNTNRTYEPKLIMPEESKIAGYHFYYLKEINEITLDSGIYKISFCNSESESWVSQHLIINIKEGADVSLILYDERKSPGSTAVEINAHRKSKSNVALLLNPDIKYPTVYLIRKALYDSSSMNSLTFSTPTSMNRIEEKAVLFENSILKHNSLSFSYKNTRVDNIIDTIQVGKNSDSDISGLGFAFDSSLSSVRGTAVITYDAKKSKSKFLVEALILGDAAKAYTMPMMKIETGDVISATHRSAQYRVSDDVLFYLQSRGLSNDEIISLLVYEKSINMANHLENIKDVSQQYIRDKLEKILNINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC84</accession>
    <name>L0AC84_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type cobalamin/Fe3+-siderophore transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232639.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1020"/>
    <dbReference type="EnsemblBacteria" id="AFZ70742">
        <property type="protein sequence ID" value="AFZ70742"/>
        <property type="gene ID" value="Calag_1020"/>
    </dbReference>
    <dbReference type="GeneID" id="14212280"/>
    <dbReference type="KEGG" id="clg:Calag_1020"/>
    <dbReference type="eggNOG" id="arCOG00198">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_2"/>
    <dbReference type="OrthoDB" id="68573at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="250" mass="28611" checksum="92D5021B7424CFC5" modified="2013-03-06" version="1">MQSIIVKDVSFSIKDKEIIKDISFELEEGEILAILGPNGVGKTTLLKIIAGLIKPTKGEVLIYKNPPEKSRKYLSYLPANANIDQYANVEDILLAMLYGKDRKFIVGNDDIKKIKNWYFKLLEKNYLKTSFNNLSSGEQRLVLLSGCFAREPKIILLDEPTAFLDITNQAKILRFIKEMALKMNITVIFTMHEIYYANIANKVLLMKNGKIKSYGKPSDVLKKDIIDDVYKIDVLEIPYDNKKIFFPSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACD2</accession>
    <name>L0ACD2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component 1</fullName>
            <shortName evidence="6">RNase P component 1</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rpp29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnp1</name>
        <name evidence="7" type="ordered locus">Calag_1375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232981.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1375"/>
    <dbReference type="EnsemblBacteria" id="AFZ71084">
        <property type="protein sequence ID" value="AFZ71084"/>
        <property type="gene ID" value="Calag_1375"/>
    </dbReference>
    <dbReference type="GeneID" id="14212635"/>
    <dbReference type="KEGG" id="clg:Calag_1375"/>
    <dbReference type="eggNOG" id="arCOG00784">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107020_3_0_2"/>
    <dbReference type="OMA" id="WHELIGL"/>
    <dbReference type="OrthoDB" id="124913at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="SSF101744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ71084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="90" mass="10258" checksum="3777E0B16C595135" modified="2013-03-06" version="1">MKINKKNLIYHEIIGLYVCIVKHLDPSIEGKCGKILYETKNTIIIETNKGKATILKKGAIFEIKIDNERVVVLGDNLIGRPEDRIKKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACF5</accession>
    <name>L0ACF5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA/RNA-binding protein Alba</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">albA</name>
        <name evidence="9" type="ordered locus">Calag_1100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232719.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1100"/>
    <dbReference type="EnsemblBacteria" id="AFZ70822">
        <property type="protein sequence ID" value="AFZ70822"/>
        <property type="gene ID" value="Calag_1100"/>
    </dbReference>
    <dbReference type="GeneID" id="14212360"/>
    <dbReference type="KEGG" id="clg:Calag_1100"/>
    <dbReference type="eggNOG" id="arCOG01753">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110989_1_0_2"/>
    <dbReference type="OMA" id="ITRHKFI"/>
    <dbReference type="OrthoDB" id="111461at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01122">
        <property type="entry name" value="AlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013795">
        <property type="entry name" value="DNA/RNA-bd_Alba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028732">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00285">
        <property type="entry name" value="TIGR00285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Alba" evidence="8">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="7">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="99" mass="10979" checksum="2E00A44788783713" modified="2013-03-06" version="1">MVCEGSPEVRVGKKPVMNYVLAVLTTLMEQNVGAVVVKARGRNITKAVDTVEIVRSRFAKNVKVKNIDVGSHEITVNDPQTNQQRTRRVSSIEICLSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACG5</accession>
    <name>L0ACG5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyhypusine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232996.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1390"/>
    <dbReference type="EnsemblBacteria" id="AFZ71099">
        <property type="protein sequence ID" value="AFZ71099"/>
        <property type="gene ID" value="Calag_1390"/>
    </dbReference>
    <dbReference type="GeneID" id="14212650"/>
    <dbReference type="KEGG" id="clg:Calag_1390"/>
    <dbReference type="eggNOG" id="arCOG04142">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039781_1_0_2"/>
    <dbReference type="OMA" id="FWSYFCQ"/>
    <dbReference type="OrthoDB" id="35308at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="310" mass="34986" checksum="ACCD96E6C53E3B01" modified="2013-03-06" version="1">MEVKPVRDVRIDPNMPIEKLIEAYGEIYGFMAGHLYESSQILKEGLKESDIRILTFTGNLVSTGLRGILSQLIEKRIFNVIITTCGTLDHDIARSNGGVYYQGYFESDDESLYKNNIHRLGNIFIKVEDYGLKVEEFVRKLVKKAVEIKDEWGIHELLNLAGGMIEDEYSILRAAKNSNADIFVPGWPDGAFGTDLFMESQRYKNFKINYFIDMKKLSDIFFNEESKATALIIGGGISKHHAIWWSQFKNGLDYVVYLTTASEWDGSLSGAMPKEAITWGKVKPKAKKSIVYGDATITLPILAASLLKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACG8</accession>
    <name>L0ACG8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="6">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glyS</name>
        <name evidence="8" type="ordered locus">Calag_1115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232734.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1115"/>
    <dbReference type="EnsemblBacteria" id="AFZ70837">
        <property type="protein sequence ID" value="AFZ70837"/>
        <property type="gene ID" value="Calag_1115"/>
    </dbReference>
    <dbReference type="GeneID" id="14212375"/>
    <dbReference type="KEGG" id="clg:Calag_1115"/>
    <dbReference type="eggNOG" id="arCOG00405">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_2_1_2"/>
    <dbReference type="OMA" id="EPSYGID"/>
    <dbReference type="OrthoDB" id="32623at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_A">
        <property type="entry name" value="Gly_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022960">
        <property type="entry name" value="Gly_tRNA_ligase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="8"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="214"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="438"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="209"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="326"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="442"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="584" mass="67288" checksum="14BFB4DC311038EA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACJ3</accession>
    <name>L0ACJ3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH:ubiquinone oxidoreductase subunit 3 (Chain A)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_1427</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1427"/>
    <dbReference type="EnsemblBacteria" id="AFZ71134">
        <property type="protein sequence ID" value="AFZ71134"/>
        <property type="gene ID" value="Calag_1427"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1427"/>
    <dbReference type="eggNOG" id="arCOG01557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147805_1_0_2"/>
    <dbReference type="OMA" id="YGYRYAK"/>
    <dbReference type="OrthoDB" id="101537at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ71134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="134" mass="15081" checksum="62ABC29E0B5C9720" modified="2013-03-06" version="1">MSIAYNPLVIAANSMIIVPAIVLLLLVAVIYLLKWLLRASPEIEKTEPYKKIPFESANPPKGVGKGKVSFQYFGYLVMFLAMEPAVVLLTFISIVPRTLIFHAILLYLILILVFAPLLAYAAYESKRIKNWILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACK4</accession>
    <name>L0ACK4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hemL</name>
        <name evidence="9" type="ordered locus">Calag_1155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232774.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1155"/>
    <dbReference type="EnsemblBacteria" id="AFZ70877">
        <property type="protein sequence ID" value="AFZ70877"/>
        <property type="gene ID" value="Calag_1155"/>
    </dbReference>
    <dbReference type="GeneID" id="14212415"/>
    <dbReference type="KEGG" id="clg:Calag_1155"/>
    <dbReference type="eggNOG" id="arCOG00918">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_1_5_2"/>
    <dbReference type="OMA" id="WGPLIFG"/>
    <dbReference type="OrthoDB" id="10264at2157"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="420" mass="46623" checksum="D281D67F96F4EA3F" modified="2013-03-06" version="1">MAESSRELFEEAKKIFPGGVNSPVRAAVKPYPFFVKYAKGAYVYTEEGNRLIDYVLGYGPLILGHANDYVLNKIKEGLNNGWLFGAPNKNEINLGKKIISYVKPGGKIRYVNSGTEATMTAIRLARGYTNRKYLVKFDGCYHGSHDSVLVQAGSAATEFGVPNTLGVPNDVAKLTLVAKYNDLNSLENIFRNYGDEIAAVIVEPVIGNMGVIKPNKDFLQGLRKITKDYGSLLIFDEVITGFRLSMGGAQKYFNIDADIVTLGKIIGGGFPVGAVVSKSEIMDYITPEGKVFNAGTFNAHPITMIAGLYTLEFMEKNNVIDKASNSAKILNELLLDYGIEYTINRVESMMQIFFTDKEINNADDARMANKELYTKFHESLINKGVFIPPSQFETMFTSYEHNEDIINYTAEKIKEVIKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACM2</accession>
    <name>L0ACM2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1472"/>
    <dbReference type="EnsemblBacteria" id="AFZ71174">
        <property type="protein sequence ID" value="AFZ71174"/>
        <property type="gene ID" value="Calag_1472"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1472"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="HFMEEAQ"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="314" mass="34747" checksum="0B276868754D018A" modified="2013-03-06" version="1">MGNEIVTINLCREFRSNKKIIKALNNINMEIPKGVTAALVGPNGAGKTTLIKILSTLMLPTSGTAYVHGFDIIKETKNVRASIGLATGGERTFYFRLTGYENLLFFASLYGLPLKDTKSKSKELLDIVGLSDFADYPYMKYSLGMQRRLALARALINDPPILLLDEPTLGIDPISAREFRRLIKMISSKKTILLTSHYMGEIEELSDIIFLIKDGKIILKGTSQELKNKIGKIIEVIVPATLVSDNLSKYVVGIRANRAYLRIPKSLIDQIDGKSEIIGETDPTLEDVYAALIGSGPIDKGTRVKPVRFGRWQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACN5</accession>
    <name>L0ACN5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protease HtpX homolog</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">htpX</name>
        <name evidence="13" type="ordered locus">Calag_1098</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232717.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1098"/>
    <dbReference type="EnsemblBacteria" id="AFZ70820">
        <property type="protein sequence ID" value="AFZ70820"/>
        <property type="gene ID" value="Calag_1098"/>
    </dbReference>
    <dbReference type="GeneID" id="14212358"/>
    <dbReference type="KEGG" id="clg:Calag_1098"/>
    <dbReference type="eggNOG" id="arCOG01331">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042266_4_2_2"/>
    <dbReference type="OMA" id="AVCCTEG"/>
    <dbReference type="OrthoDB" id="62484at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="12">
        <location>
            <begin position="122"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ70820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="384" mass="42967" checksum="239EF70254390BDC" modified="2013-03-06" version="1">MIIGILGFMLVYWWIMILGSLVAGVIVALLTLSAPKIVSKEPESLSSLRYSMALSAIAIILAGIGVFIGSAELLSYAFGLPLVGSSIVIGAVIFTGFIIILQWLFSPFLINLMYKTHPPKTQEELRLQKSLENVAKKSNIKVPKLRIAEVNIPNAFSYGSPLTGNFVAVTRGIMDIMPEDEMEAVLGHEVGHLRHRDVSFILALSLIPLAVYYLGQILIWNGLLGGGNNDRNQVSGNFLLLIVGIILMAAAVLFRFLVAHFNRLREYYADANSAIVTKDPRKLQRALARLEVTYDSSRRLKREAKNNSTAQMLFIIAPFVEIQGGFFFSIDYSRKGYRIDDIDEVVEELKHKETDPREEIIATHPPTPKRIRFLDNLAKRLEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACT1</accession>
    <name>L0ACT1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233131.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ71234">
        <property type="protein sequence ID" value="AFZ71234"/>
        <property type="gene ID" value="Calag_1535"/>
    </dbReference>
    <dbReference type="GeneID" id="14212796"/>
    <dbReference type="KEGG" id="clg:Calag_1535"/>
    <dbReference type="HOGENOM" id="CLU_2165125_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="110" mass="12210" checksum="4233A59F91378516" modified="2013-03-06" version="1">MVKNLSINNFYSSEGISISSIGNIIIENVISNVNNGNQGDIYINNNNNLNIYNITENIYNGTFFQDIITTGLKIINLNNGVDNLQNIKINAYYSNPNASANGLNYLMEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACU4</accession>
    <name>L0ACU4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233146.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1551"/>
    <dbReference type="EnsemblBacteria" id="AFZ71249">
        <property type="protein sequence ID" value="AFZ71249"/>
        <property type="gene ID" value="Calag_1551"/>
    </dbReference>
    <dbReference type="GeneID" id="14212813"/>
    <dbReference type="KEGG" id="clg:Calag_1551"/>
    <dbReference type="eggNOG" id="arCOG02172">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2284892_0_0_2"/>
    <dbReference type="OMA" id="PLWEVTG"/>
    <dbReference type="OrthoDB" id="140248at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="109" mass="12577" checksum="32E734D1D36F437D" modified="2013-03-06" version="1">MNWKLCVSDNISVAMKIKSMGYDIHGHDIKITLCICEKAIDNKPVIDMETLQEKLSTFLKSINRKPLWEVTGNEGTFEDLLFYIKDNINIKNICQISAQIPNKEIYLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACV4</accession>
    <name>L0ACV4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233156.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1561"/>
    <dbReference type="EnsemblBacteria" id="AFZ71259">
        <property type="protein sequence ID" value="AFZ71259"/>
        <property type="gene ID" value="Calag_1561"/>
    </dbReference>
    <dbReference type="GeneID" id="14212823"/>
    <dbReference type="KEGG" id="clg:Calag_1561"/>
    <dbReference type="eggNOG" id="arCOG01618">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_2"/>
    <dbReference type="OMA" id="HVDREGT"/>
    <dbReference type="OrthoDB" id="35652at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="316" mass="36333" checksum="E2B843C4047D8038" modified="2013-03-06" version="1">MEFTNLGKTNEKISRIGLGAWQFSDAWGVTEYNIAKQVVSSSIELGINLIDTAMVYGRGMSESFLGKALRELNIERSSVFIVTKIPGEFLSYDDVFKAVDRSLERLQTDYIDALLAHWPPVWHNHPTCEYMKAFERLVELGKIRYIGLSDYPPELAEAARYCLSKNDLQIMEIRYNLVERQAEKEIIPYVESSEMTMLAWSPLAKAAILGKYSMEEINNFRDVRRNDAVFYPENYKQILKLADVIKEIAKKYDKTPSQVALNWLMNYSKNIVPIPGAKSKEQAIENAGSVGWKLSYSDWRKIDEISKSIKFTYVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACW7</accession>
    <name>L0ACW7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232884.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1271"/>
    <dbReference type="EnsemblBacteria" id="AFZ70987">
        <property type="protein sequence ID" value="AFZ70987"/>
        <property type="gene ID" value="Calag_1271"/>
    </dbReference>
    <dbReference type="GeneID" id="14212531"/>
    <dbReference type="KEGG" id="clg:Calag_1271"/>
    <dbReference type="eggNOG" id="arCOG00614">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099718_0_0_2"/>
    <dbReference type="OMA" id="SEFRAWY"/>
    <dbReference type="OrthoDB" id="118207at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="195" mass="21879" checksum="103252BF8937BAE0" modified="2013-03-06" version="1">MERRSWREVVFAEISEPLSWILGILSITVALGGSQISNLYFYISPIFIGIIVGFVSHEYMHRYLSRKYHMVSRYTANVLGVLITLVSALLPIKLLMPGYVKTWALGPTSRKGILYSVAGGPITNIVIALALFVASFAFSSTFYFNFLRTVGWVNAYISLFNLIPIPPLDGDKIIRLDIVLWAILFIISLALVFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD01</accession>
    <name>L0AD01_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal-transduction protein containing cAMP-binding and CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232914.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1304"/>
    <dbReference type="EnsemblBacteria" id="AFZ71017">
        <property type="protein sequence ID" value="AFZ71017"/>
        <property type="gene ID" value="Calag_1304"/>
    </dbReference>
    <dbReference type="GeneID" id="14212564"/>
    <dbReference type="KEGG" id="clg:Calag_1304"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_1_2"/>
    <dbReference type="OMA" id="ERDMVYV"/>
    <dbReference type="OrthoDB" id="83765at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="133" mass="14644" checksum="ADA4654F183AE534" modified="2013-03-06" version="1">MSSVLSMKVSDFMKKAITTFPNVTIAEIAKIMYENRIGSVVITSPDDKVLGIFTERDLTRVVAEGVPLDKHVGDVMTKNPVLITQSEGLSKAISLMYEKNVRHLPVVDNEGKIKGIISVRDLTSILNKLTSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD69</accession>
    <name>L0AD69_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps3</name>
        <name evidence="10" type="ordered locus">Calag_1373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds the lower part of the 30S subunit head.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232979.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1373"/>
    <dbReference type="EnsemblBacteria" id="AFZ71082">
        <property type="protein sequence ID" value="AFZ71082"/>
        <property type="gene ID" value="Calag_1373"/>
    </dbReference>
    <dbReference type="GeneID" id="14212633"/>
    <dbReference type="KEGG" id="clg:Calag_1373"/>
    <dbReference type="eggNOG" id="arCOG04097">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_1_1_2"/>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="OrthoDB" id="60366at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_A">
        <property type="entry name" value="Ribosomal_S3_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027488">
        <property type="entry name" value="Ribosomal_S3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_S3_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ71082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="247" mass="27934" checksum="6BE92BCB2E01E30D" modified="2013-03-06" version="1">MSRIKKYFLDQAMLRAKIDEYLAQNFYTAGYSGVHIIQSGLGTRIHIYAERPALIIGRKGATIRRLQGVFQKVFGLENVQVTVSQPDNTELDARIQAFRVARSLEMGYHFRRVAMATLRRIIEAGAIGAEIVISGKLTNERAKFEKLQMGKVIKTGDIVDQYVDKAVAHAKLPQGIYGVRIIIVKQQASMPHIYEKGEDEIKNVVQSLKEQVEEIKSTEGQEKLEEMIEEIKEEEVEEGGEIQAQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD73</accession>
    <name>L0AD73_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR00270 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1286"/>
    <dbReference type="EnsemblBacteria" id="AFZ71000">
        <property type="protein sequence ID" value="AFZ71000"/>
        <property type="gene ID" value="Calag_1286"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1286"/>
    <dbReference type="eggNOG" id="arCOG01863">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130237_0_0_2"/>
    <dbReference type="OMA" id="VQCEMCG"/>
    <dbReference type="OrthoDB" id="105095at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004451">
        <property type="entry name" value="CHP00270"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00270">
        <property type="entry name" value="TIGR00270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="80"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="163" mass="18426" checksum="84FEF92E66CCBB46" modified="2013-03-06" version="1">MGEELYCEMCGTLIRGKPFKALVDGAEMILCATCYNKLMKSGRALPAPERKIEPKKVEKVKKTSKPIDQLEIIEGFGEEIRKGREAKGWTQAVLAQKLRISEAMLKKIESEKIKPSLDLAKRIEQILKIKILQPVEFDEGEEKGSSIDNVTFGDVVFVRRDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADH2</accession>
    <name>L0ADH2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233069.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ71172">
        <property type="protein sequence ID" value="AFZ71172"/>
        <property type="gene ID" value="Calag_1470"/>
    </dbReference>
    <dbReference type="GeneID" id="14212730"/>
    <dbReference type="KEGG" id="clg:Calag_1470"/>
    <dbReference type="eggNOG" id="arCOG04203">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_656576_0_0_2"/>
    <dbReference type="OMA" id="GTMLDHV"/>
    <dbReference type="OrthoDB" id="76036at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025105">
        <property type="entry name" value="DUF4010"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13194">
        <property type="entry name" value="DUF4010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4010" evidence="7">
        <location>
            <begin position="181"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="412" mass="44901" checksum="92FE6AA06522BB13" modified="2013-03-06" version="1">MININLTNLLMAIAVGGIVGFVNEYRKISGARLFLGLRTAIFISLLGYMFSIFTLLFPGYIALLSAIITITTISTSIYLEKVKATGSPGGTTYVSIFLVFFSGLLEGLGYYELGVIISVLVAALGIYKTQLLDAISKIRKEELLAILNLMILSLVILPLLPNKNIGPYGIFNPFQFWLIVVVIGIIFVAQYIVLKIYKKGLIAFSIIGGLVSSTTVTLSLIELSNKEKNIGKTIAYNIILSNIPLVLVQALAFSYFSTYSSKLIYYITPSILVLILALIIIGSIGYKHITVSGIPSPETPLPIGKVIEFGVVFFIVMIISKLVSILVSYLLPLALFVSSFANVAGVVFSIALLYIHGQINAKYAAYLIQLALIAGIIEKGFLAFLSKDKEVRNLTLILSLILIGILILMMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADL2</accession>
    <name>L0ADL2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233017.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1413"/>
    <dbReference type="EnsemblBacteria" id="AFZ71120">
        <property type="protein sequence ID" value="AFZ71120"/>
        <property type="gene ID" value="Calag_1413"/>
    </dbReference>
    <dbReference type="GeneID" id="14212673"/>
    <dbReference type="KEGG" id="clg:Calag_1413"/>
    <dbReference type="eggNOG" id="arCOG01761">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132460_0_0_2"/>
    <dbReference type="OrthoDB" id="82272at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="197" mass="23412" checksum="62595119ECC68EB4" modified="2013-03-06" version="1">MQIPLDKICVKSGILCPNCQAKIDKGLYEKWEVDVMKVLVELEDKIKGLRDVNYKKSIVFDRKLYIILENLGSHRHELEKYLREKLRNFNFDRIVLIEYASNPKELVYKLLANVEIKSTNIYYSPDGIVYYVAKIPSYEKPKVDEIGDSVKRIFKILTRNDIYFEFVDYPKYKKINEEEKIEQHIDANQLDKLLKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADQ0</accession>
    <name>L0ADQ0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein involved in ribosomal biogenesis, contains PUA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233062.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1461"/>
    <dbReference type="EnsemblBacteria" id="AFZ71165">
        <property type="protein sequence ID" value="AFZ71165"/>
        <property type="gene ID" value="Calag_1461"/>
    </dbReference>
    <dbReference type="GeneID" id="14212721"/>
    <dbReference type="KEGG" id="clg:Calag_1461"/>
    <dbReference type="eggNOG" id="arCOG00993">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1598917_0_0_2"/>
    <dbReference type="OMA" id="CYEINCI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0113" evidence="1">
        <location>
            <begin position="102"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="173" mass="20133" checksum="1019CF035C609FEB" modified="2013-03-06" version="1">MQAKKEPKLEKLSKQELNVIKKFLDEIGVKLYSIASNPMKLVVENAFYNDIFDIPIQLKELVLNLDSIYSSGFYLGYIKKEKFYPGLPLLRRISRLCYEINCIKLNEFGEKLFLYGKRVENDNIILFKEGFCLVLNQQNEPLGWGIGKVINVHKEIKIVEPVKDLGWYLRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADQ1</accession>
    <name>L0ADQ1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Mevalonate kinase</fullName>
            <shortName evidence="10">MK</shortName>
            <shortName evidence="10">MVK</shortName>
            <ecNumber evidence="2 10">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mvk</name>
        <name evidence="13" type="ordered locus">Calag_1564</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="2 10"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233159.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1564"/>
    <dbReference type="EnsemblBacteria" id="AFZ71262">
        <property type="protein sequence ID" value="AFZ71262"/>
        <property type="gene ID" value="Calag_1564"/>
    </dbReference>
    <dbReference type="GeneID" id="14212826"/>
    <dbReference type="KEGG" id="clg:Calag_1564"/>
    <dbReference type="eggNOG" id="arCOG01028">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_0_0_2"/>
    <dbReference type="OMA" id="NTVCTYG"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00217">
        <property type="entry name" value="Mevalonate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022937">
        <property type="entry name" value="Mevalonate_kinase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="PTHR43290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="11">
        <location>
            <begin position="93"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="12">
        <location>
            <begin position="227"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ71262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="323" mass="34581" checksum="0840FF24BCE8382C" modified="2013-03-06" version="1">MNKSIAISPGKVILFGEHFVVRGTKAIVAAIDLYAKAEIEESSWPSEIISEGTEIRGKITQELKVVGSKELEPFARILSVLKNWGFQIAGFKAKISSEIPMSAGLGSSAASAAAFSLSYANLLGYKLNDKELFTLSHEAEKITHGNPSGVDSAAVTYGGILVFKKDVGIISKLKSLFSDKYSLIIADTGIKRSTSVPVRDVLILSEKLWPAVSLIYDASDRIVDLANEAINNEDYETIGTLMNINQGLLNSMGVSSLELEELIYRSRLAGAIGAKLTGAGKGGSAIILAPSNKVDNILDRIKCCSKWASRIKISQEGARIISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADT9</accession>
    <name>L0ADT9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps10</name>
        <name evidence="6" type="ordered locus">Calag_1509</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233107.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1509"/>
    <dbReference type="EnsemblBacteria" id="AFZ71210">
        <property type="protein sequence ID" value="AFZ71210"/>
        <property type="gene ID" value="Calag_1509"/>
    </dbReference>
    <dbReference type="GeneID" id="14212770"/>
    <dbReference type="KEGG" id="clg:Calag_1509"/>
    <dbReference type="eggNOG" id="arCOG01758">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_0_1_2"/>
    <dbReference type="OMA" id="QFEIRVH"/>
    <dbReference type="OrthoDB" id="107993at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_S10_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="103" mass="12179" checksum="8F486D7F04F35351" modified="2013-03-06" version="1">MAFKVRIWLWSTNVKSLESVVNQIREIAQKTGVPVRGPIPLPTKRLEMPLLRLPHGEGSKHWEHWEMRIHKRLIDIEADERVLRRLMRIQVPPDVYIEIKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADY8</accession>
    <name>L0ADY8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233167.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1572"/>
    <dbReference type="EnsemblBacteria" id="AFZ71270">
        <property type="protein sequence ID" value="AFZ71270"/>
        <property type="gene ID" value="Calag_1572"/>
    </dbReference>
    <dbReference type="GeneID" id="14212834"/>
    <dbReference type="KEGG" id="clg:Calag_1572"/>
    <dbReference type="eggNOG" id="arCOG00235">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_3_1_2"/>
    <dbReference type="OMA" id="YALSIDM"/>
    <dbReference type="OrthoDB" id="72644at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="293" mass="32647" checksum="5DB2B5B250CE57CA" modified="2013-03-06" version="1">MSYSSLKIGSVFYENKLHLSLFKDGLFYISDKSEINNELLDIKNFYINLPKSLVHIRENHEKFTLKTNYNLDSTLMPPNPFPSKIVGIGKNYISHAKEMKGSIKPAFFLKAPSALIGSNTDIVVPSFIKKPDYEGEVVILIGKKVKNASLKEAKESIVGYTAGNDFTARDLQYGDNNTECLPWSQAKSLDTFSPTGPYIKIIDDYSELENVCVTTRLNGKTVQQGCPSEMFYDYANVVLEVSKLMTLYPGDLVFTGTPSGVGHAKGNYLNDGDVIEVIVTGIDPLRNKVVRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7N8</accession>
    <name>L0A7N8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231734.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0044"/>
    <dbReference type="EnsemblBacteria" id="AFZ69836">
        <property type="protein sequence ID" value="AFZ69836"/>
        <property type="gene ID" value="Calag_0044"/>
    </dbReference>
    <dbReference type="GeneID" id="14211304"/>
    <dbReference type="KEGG" id="clg:Calag_0044"/>
    <dbReference type="eggNOG" id="arCOG00132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025894_3_1_2"/>
    <dbReference type="OMA" id="APRTAFI"/>
    <dbReference type="OrthoDB" id="74502at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="391" mass="42446" checksum="F133F808B20C9D3E" modified="2013-03-06" version="1">MSNTRNSLNYLAIIRIMRSVSAGIISIVYPYIAIKMLHFNLSTLGLVYALAALFTALFSIAFGYLADFIGRKLSLLFSSLVLTISILILLIKINFITAVIAAILGGISNTGAMAGGGIGGAVAPVQNALIADFTTRKNRTTLISLMAFFGNIAAAGGTLLGGIFSYRIELELATIISIIPLIFVYFIESQHIRAKSIKMKSGNVTLKFSITGILNGLTSGLVTPFLIPIFIVLYDVSRSYMSIYTTIASLIATFSMLLAPKIDKALGFLRSIYITRGLTIPLILIFPFIRILPVSLGIYIIFPALRVIAIPIQQSAMLSMVPPEERGRISGLNQGSRLGFSSIGTFIASPFMDISLIYLPFVSYSVFMALNIYLYKRFFGGKNGSQAFQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7T4</accession>
    <name>L0A7T4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trpD</name>
        <name evidence="6" type="ordered locus">Calag_0103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231789.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0103"/>
    <dbReference type="EnsemblBacteria" id="AFZ69891">
        <property type="protein sequence ID" value="AFZ69891"/>
        <property type="gene ID" value="Calag_0103"/>
    </dbReference>
    <dbReference type="GeneID" id="14211363"/>
    <dbReference type="KEGG" id="clg:Calag_0103"/>
    <dbReference type="eggNOG" id="arCOG02012">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_3_1_2"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="OrthoDB" id="77838at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="73"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="106"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="345" mass="38537" checksum="0B41088CE3C9A0E0" modified="2013-03-06" version="1">MKPNEYLKLIAERKNLTQEEAEELANMLLDKNIDESLASAILISLKMKGETSDEIVGFVRSLRKHALGFDYRDAIDIVGTGGDGLNTINVSTISSILISNKYKVAKHGNRASSSLSGSADFLETVGYNINIDVNKAKELLEKTNFVFLFAQAYHLSMKNVAGIRKKLGIRTIFNLIGPLSNPFNVDTILIGVYPYNYIDVLADAVKELKYKRAILVSGEPGLDEVSPMGKTTVIEIKNDKEDRYQLSPEDFKIERFNINKVSVNNPEESAIRAIRASIGKDEFAEKFIRINTSMGLYLINEVDSLYEGYEVSGELLSKLPQRLIDLVSINGNQDKLKNILVRAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7X4</accession>
    <name>L0A7X4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231871.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0190"/>
    <dbReference type="EnsemblBacteria" id="AFZ69973">
        <property type="protein sequence ID" value="AFZ69973"/>
        <property type="gene ID" value="Calag_0190"/>
    </dbReference>
    <dbReference type="GeneID" id="14211450"/>
    <dbReference type="KEGG" id="clg:Calag_0190"/>
    <dbReference type="eggNOG" id="arCOG05195">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1381338_0_0_2"/>
    <dbReference type="OMA" id="GWCAFKL"/>
    <dbReference type="OrthoDB" id="101657at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="197" mass="23207" checksum="46352A8B52D11B4C" modified="2013-03-06" version="1">MDETETLYKVAESMLCMMKWNYCEETYRMLINMVSNKRSTDLNLAGLWHGYAICLERTGKKEESIKAYRIALELYLNNFDKDKRKSYLWGGWCAFKLGKYDLSYRLFEKAVKEDPGYAYSWLSLSMASNKIGNKKRGKEALENYYKIVKLSPYKKRECEGKLMLYQAYGESNGWVKDYIEKLINKIKDDPSLIACRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0A829</accession>
    <name>L0A829_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NurA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0204"/>
    <dbReference type="EnsemblBacteria" id="AFZ69986">
        <property type="protein sequence ID" value="AFZ69986"/>
        <property type="gene ID" value="Calag_0204"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0204"/>
    <dbReference type="eggNOG" id="arCOG00287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_680783_0_0_2"/>
    <dbReference type="OMA" id="GFREYAF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="127"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="404" mass="46492" checksum="AEF71B49B6401BA8" modified="2013-03-06" version="1">MNLDMPTKIINSLGNDIISSYKTSYSKKRFLLTLKDIIEEDVNENETKAELYEYSSRFFNSKKIVNDKNLFVIGLDSSSRAIITPIADIIISAVSISGQGPVELSDWPYLYRDLAYIPINPEPFIYVASDDLNVSDYSNEYIKQFRSLDNEDDLSKIMDYSRLSLESWGIKEPSFALGNYFKRKGKKFVLLLDGPIYLLDNKNDYIKSNLMKNRSNEIEILENQGIPVIGVVKRIERSKILTNVQDFSNILSQCIGNYETLNDSLIIQKMLYSNCYNNYYGKILTTPKIKVRSNGLDKIVEYVLIPPSRYQSINKGRIFRLEYTEKTLDILNNNYSLEPVQILINDSIFKQSNESITIAYSDKRGKMITQILKDLFINTIVGRGAPISYDTLREAEATWIKRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A842</accession>
    <name>L0A842_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231936.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0257"/>
    <dbReference type="EnsemblBacteria" id="AFZ70038">
        <property type="protein sequence ID" value="AFZ70038"/>
        <property type="gene ID" value="Calag_0257"/>
    </dbReference>
    <dbReference type="GeneID" id="14211517"/>
    <dbReference type="KEGG" id="clg:Calag_0257"/>
    <dbReference type="eggNOG" id="arCOG11240">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2340004_0_0_2"/>
    <dbReference type="OMA" id="WSFEIAI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="97" mass="11318" checksum="9A55F82F81866E26" modified="2013-03-06" version="1">MLKLLSVWSFEIAITIISVIFVYYIFKFYYSSSKSVKSQFLSRLKTFSGIFLAQTIFTTVSSIFLSMKYNEVVAIPMLIISLLELLGFIYLFRIVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A843</accession>
    <name>L0A843_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231899.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0219"/>
    <dbReference type="EnsemblBacteria" id="AFZ70001">
        <property type="protein sequence ID" value="AFZ70001"/>
        <property type="gene ID" value="Calag_0219"/>
    </dbReference>
    <dbReference type="GeneID" id="14211479"/>
    <dbReference type="KEGG" id="clg:Calag_0219"/>
    <dbReference type="eggNOG" id="arCOG03773">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124259_0_0_2"/>
    <dbReference type="OMA" id="NITARTY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="44"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="169" mass="19787" checksum="98DCE3D591245E18" modified="2013-03-06" version="1">MDQDDIINRYDFTYEGYDELYGEEQKNKYDLLFSKIKPYGIVADIGCGTGLLMEYFYDTGLIDKINKYICLDLSINMLSLSNKRANKFCKDKCLVLWGNAEYLPFKNKSIDFLFSFSVINLLDNPENALNEFKRVSNNIFVSYVKKLKQVNMQGEIIGEDYKDLIFKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0A890</accession>
    <name>L0A890_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231949.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70051">
        <property type="protein sequence ID" value="AFZ70051"/>
        <property type="gene ID" value="Calag_0271"/>
    </dbReference>
    <dbReference type="GeneID" id="14211531"/>
    <dbReference type="KEGG" id="clg:Calag_0271"/>
    <dbReference type="HOGENOM" id="CLU_2091180_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="116" mass="13486" checksum="C1CA1C1F071A1BC8" modified="2013-03-06" version="1">MGETYYTLFDDYNINNINLNAKLIFSSLFKIKTSYLDKYEFCDQFNSQSIDCSNLKKVIEFISCKSAIKLSYMKSSISLYDQTIKKNIESVLNNCNNDYIKESLKNILSFLTSYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8B6</accession>
    <name>L0A8B6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin oxidoreductase frp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231979.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0302"/>
    <dbReference type="EnsemblBacteria" id="AFZ70081">
        <property type="protein sequence ID" value="AFZ70081"/>
        <property type="gene ID" value="Calag_0302"/>
    </dbReference>
    <dbReference type="GeneID" id="14211562"/>
    <dbReference type="KEGG" id="clg:Calag_0302"/>
    <dbReference type="eggNOG" id="arCOG00288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_0_1_2"/>
    <dbReference type="OMA" id="GMCLGYP"/>
    <dbReference type="OrthoDB" id="119612at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016446">
        <property type="entry name" value="Flavin_OxRdtase_Frp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43425">
        <property type="entry name" value="PTHR43425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005426">
        <property type="entry name" value="Frp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="246" mass="28235" checksum="6605ACBB1BD182EA" modified="2013-03-06" version="1">METETIKVILNHRSIRKFKTGVSIPDEDLKLIMESAQRAPTDASLHLWSAIRITDREKRKEIAELIRQKHVEEAQEFFIFLADLYRNTALMKHLKINRAKDDFVPLIFAAIDAALAADRMAIAAESLGYGICFIGGVQDNPKEIIEILDLPERTYPLFGLIIGIPDESPSLRKRLPINYLIHENRYNDYSEKDLNFLLDYMADIGKNGFQGLLAKYMSDKGKFSLRNEEFLNIIKQLGFDLELTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8B9</accession>
    <name>L0A8B9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231991.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70093">
        <property type="protein sequence ID" value="AFZ70093"/>
        <property type="gene ID" value="Calag_0315"/>
    </dbReference>
    <dbReference type="GeneID" id="14211575"/>
    <dbReference type="KEGG" id="clg:Calag_0315"/>
    <dbReference type="eggNOG" id="arCOG11636">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1451352_0_0_2"/>
    <dbReference type="OMA" id="WIDACKI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="186" mass="21539" checksum="2B5842FF5DE05F35" modified="2013-03-06" version="1">MPRIDNDYYVIDISQIFELTNEEIKKIINWILDKNSYFVVQPSIVVVDKVKKIRYALGIGSIVVDSEPPINYLKIFGSEWIDACKIQDKRIKEVIYANDYFEPIKGLLISLETKSPFLVLNGIVSELNINKNQNKGIPLLIIKDENSSYTVVSMDKDHFYINVNESNYGKIVYYIAELFSHCENPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8G7</accession>
    <name>L0A8G7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0379</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232051.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0379"/>
    <dbReference type="EnsemblBacteria" id="AFZ70153">
        <property type="protein sequence ID" value="AFZ70153"/>
        <property type="gene ID" value="Calag_0379"/>
    </dbReference>
    <dbReference type="GeneID" id="14211639"/>
    <dbReference type="KEGG" id="clg:Calag_0379"/>
    <dbReference type="eggNOG" id="arCOG00894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02228">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039727_0_0_2"/>
    <dbReference type="OMA" id="TAYIHGF"/>
    <dbReference type="OrthoDB" id="96698at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="7">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="8">
        <location>
            <begin position="234"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="351" mass="39745" checksum="E9214BAE4252B499" modified="2013-03-06" version="1">MNNDKVSIIIPTYNEAENIGNLIRNIESELSNHVNDYEIVVVDDNSPDKTYEIVDKISKNDNHVKLILRKEKKGLSSAIFDGIKKSSGNIIVVMDADYQHPPEKIPKLIESLKNYDVAVASRYTKGGKTEGFSFYRKIVSKGATLLAKILVPEVNKTSDPMSGFFAFRKDSVNLNKLNVIGYKILFEILYKNPNLKVIDVPYTFKKRSKGKSKLGIKEIFEFLIHVIINSRVIKFGIIGALGTIVNLGIMYLLISKGLFYDYASAIAIETSILFNFTLNDKWTFKDKKGRPLLSRILRYNLIVGPSGVTIFFVMELLTKLLKIYPLMGQFIGIIFGFVVNFLLSYSKVWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8H4</accession>
    <name>L0A8H4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0344</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232019.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0344"/>
    <dbReference type="EnsemblBacteria" id="AFZ70121">
        <property type="protein sequence ID" value="AFZ70121"/>
        <property type="gene ID" value="Calag_0344"/>
    </dbReference>
    <dbReference type="GeneID" id="14211604"/>
    <dbReference type="KEGG" id="clg:Calag_0344"/>
    <dbReference type="eggNOG" id="arCOG00184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="EPLRTYY"/>
    <dbReference type="OrthoDB" id="41087at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="422" mass="47898" checksum="8B6E4700C4E02F32" modified="2013-03-06" version="1">MIIAARELSKFFDVKGVKNAKIRAVENVNIEIKEGEIVGLVGESGSGKSTLGRLLIRLIEPTSGEILYNIPDDELDEFDNALKSNDRNAIEKIANKYSIMRLHGKELKTFRRNVGIVFQDPYSSLDPRMKIEDIIAEPIVETGYLNGEKVKERVLELLDEVQLPREFSFRYPHELSGGQRQRIALARGIATNPKLVILDEPTSALDVSIQAEILELLKGLRKKYNMAMLLITHNISVISYMADRVFVMYAGKIMEKGNKIDIIKNPEHPYTQALISAVPQIKRVKARIILKGDPPNLINPPKGCRFHPRCPVALPVCGWTADEVKPTLDYLIDTKYFTEFSNTKVEVRNELELAVYNAKADKLKEIINVEKENLRPLMSIKDVIEENGNVTIKLYQYETPELIELENGREVECLLFSKPQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8H5</accession>
    <name>L0A8H5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0392"/>
    <dbReference type="EnsemblBacteria" id="AFZ70163">
        <property type="protein sequence ID" value="AFZ70163"/>
        <property type="gene ID" value="Calag_0392"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0392"/>
    <dbReference type="eggNOG" id="arCOG00242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_3_2"/>
    <dbReference type="OMA" id="LNWMRAM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="269" mass="29994" checksum="AB4683A5D5E05596" modified="2013-03-06" version="1">MQYELAASHEIVMSEKRKLCYWIYLNRPEKLNALDTKTWNKLIEELNKGCKSDSVAIVLTGKGRAFSTGDDINEMLKLNTKEEAIKFFNGIKQTLNIMISCEKPIISLVNGLAVGGGAEILLASDIVIASDNSWFSFPEISLGLIPPILISVGGGALGFRRSKYLALTGTRFSAQEAKNMGLVDEIVPQVDLEKEAFAIADTLSNYSQEAINSIKRITYEIYWKDLEKSIDALTDLVITKDAKYKMESFESHKLKPVKNHNLVVNKNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8J9</accession>
    <name>L0A8J9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232049.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0377"/>
    <dbReference type="EnsemblBacteria" id="AFZ70151">
        <property type="protein sequence ID" value="AFZ70151"/>
        <property type="gene ID" value="Calag_0377"/>
    </dbReference>
    <dbReference type="GeneID" id="14211637"/>
    <dbReference type="KEGG" id="clg:Calag_0377"/>
    <dbReference type="eggNOG" id="arCOG00933">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023791_0_0_2"/>
    <dbReference type="OMA" id="RCDIHYA"/>
    <dbReference type="OrthoDB" id="13164at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034471">
        <property type="entry name" value="7_8-dihydro-6-hydroxymethylpte"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034474">
        <property type="entry name" value="Methyltransferase_Class_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43306">
        <property type="entry name" value="PTHR43306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00385">
        <property type="entry name" value="7_8-dihydro-6-hydroxymethylpte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="144"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="595" mass="68426" checksum="C5AF9DA407000D71" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8K8</accession>
    <name>L0A8K8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">rRNA metabolism protein, SBDS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232101.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0435"/>
    <dbReference type="EnsemblBacteria" id="AFZ70203">
        <property type="protein sequence ID" value="AFZ70203"/>
        <property type="gene ID" value="Calag_0435"/>
    </dbReference>
    <dbReference type="GeneID" id="14211695"/>
    <dbReference type="KEGG" id="clg:Calag_0435"/>
    <dbReference type="eggNOG" id="arCOG04187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043216_2_0_2"/>
    <dbReference type="OMA" id="AVNPQMD"/>
    <dbReference type="OrthoDB" id="59861at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="PTHR10927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="SSF109728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="SSF89895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBDS" evidence="2">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="SBDS_C" evidence="3">
        <location>
            <begin position="100"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="232" mass="26112" checksum="90758C544B87D9B1" modified="2013-03-06" version="1">MTKKQEFIIAWIELKGQKFEIPVKPDLAFKFREGEKVSISEVLWADTIFKDVKKGLKASPDSLRKAFGTEDIEKIAEKILKEGQIQLTEEERKKMIEAKRKQIINYIVKNTIDPKSGKPIPEQRIENALDQVRFNIDPFKGAEAQALEAVKKLSILMPIKVAKALLEITIPSEYASRAYKEIQRIGEVKKANWGSDGSLKVELEIPAGAQIEVIDKVQSLAKGQANISVKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8M0</accession>
    <name>L0A8M0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232079.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0412"/>
    <dbReference type="EnsemblBacteria" id="AFZ70181">
        <property type="protein sequence ID" value="AFZ70181"/>
        <property type="gene ID" value="Calag_0412"/>
    </dbReference>
    <dbReference type="GeneID" id="14211672"/>
    <dbReference type="KEGG" id="clg:Calag_0412"/>
    <dbReference type="eggNOG" id="arCOG01481">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043773_0_0_2"/>
    <dbReference type="OMA" id="EVRWTLD"/>
    <dbReference type="OrthoDB" id="56885at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_C" evidence="8">
        <location>
            <begin position="122"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="398" mass="44328" checksum="DBFFC02DCC168982" modified="2013-03-06" version="1">MDGNKEPKIYMASLEEILNGEATDIYFKRTKEVLEEAGLADVKVRMEVHLYGNPPEGRNWAVYAGLEEAIALLKGKPFNLYSVPEGTLFIRKMPLMIVEGKYIDFALLEAPLLGLLRFSSSIATKTASLKRVVGNKILLFFGIRALHPAVFPAADRAAFIGGADSISGVLSEKYLGLTPQGTMPHALILVFGDQKEAWKWFAKLYEGKINIVALADTLDDERKEALMAANLLGDKLWGIRLDTPASRRGNMKDIVEEIRWTLDLNGFKHVKIIVSGGLDENSILNLKDLVDGFGVGTSIATAPSVDLSMDIVEIDRGNGWEPYTKRGKLPGAKKVYSCKPLEYYIKYWNDNEIPTCTDKNDKPVNLMKLYLNNGNLVEPLPSLDDIRKYVLSQLQFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8M5</accession>
    <name>L0A8M5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_0417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232084.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0417"/>
    <dbReference type="EnsemblBacteria" id="AFZ70186">
        <property type="protein sequence ID" value="AFZ70186"/>
        <property type="gene ID" value="Calag_0417"/>
    </dbReference>
    <dbReference type="GeneID" id="14211677"/>
    <dbReference type="KEGG" id="clg:Calag_0417"/>
    <dbReference type="eggNOG" id="arCOG00767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_0_2"/>
    <dbReference type="OMA" id="VDCGNGM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="154"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="259"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="407"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="481" mass="53567" checksum="27DEADD6F20E2046" modified="2013-03-06" version="1">MKLFGTAGIRGLYPVKINPILSYKTGLSLANYYGGKGEAIVGKDVRNTSDVLSFSLSSGLMAGGMNVTYIGISPTPLVAYSTDRLNAKVGVSVTASHNPPEDNGIKIFGQNGIEINELDENKIEEIILNGKEGDLQKSWEEVGSLSFNNYIEKKYEEDIVNHINFISNQRKLKILIDCANGSASNITPTILTKLKVGQIIGINCNYDSKFQARLPEPRPDVLQQSISVMNQLGADLLIAHDGDADRMAIAVPGLGFVKQDIVIALFAKYFLSNKKGDIVVSLDVGNEVEELVENYGGKIIRAKLGKIHEKAIESKNVLMAAEPWKLIDPSFGLWVDGIYEAALISKIFAEEKRKPIEIIKDIKIYPSARISLNLSIPEDFNLNKESIVKQILDNFASELDKDSYNIIDIDGYRINFKDKSWILFRASGTENKIRFYIQSYEKNKLKELIEKAKEIGIQVLNKYSIKIKGIEEYVEMGNENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Q2</accession>
    <name>L0A8Q2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231697.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0003"/>
    <dbReference type="EnsemblBacteria" id="AFZ69799">
        <property type="protein sequence ID" value="AFZ69799"/>
        <property type="gene ID" value="Calag_0003"/>
    </dbReference>
    <dbReference type="GeneID" id="14212800"/>
    <dbReference type="KEGG" id="clg:Calag_0003"/>
    <dbReference type="eggNOG" id="arCOG00505">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061385_1_0_2"/>
    <dbReference type="OMA" id="GPRYIAY"/>
    <dbReference type="OrthoDB" id="50620at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07726">
        <property type="entry name" value="ST1585-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037482">
        <property type="entry name" value="ST1585_MBL-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="23"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="302" mass="33864" checksum="3FA52D0163283DDD" modified="2013-03-06" version="1">MNKYEKFGDLFIVDVSPGDLHGIVSSFILVDDKVTIIEPGPASQYNKLKNALLDLNLKPDIIISTHIHLDHAGSTGHLINDYPNAKAYVHPKGAKHIIDPSQLWDAANKFSKLLADNYGKPLPVKESNVIVPDDYSEINIGKHKVKFIYTPGHASHHMSILLYPENIIFTGDSAGGIFNFKSGKVYAITSPTPFKPIQYLESLEKMKSFKPKYIAPTHYGIHENGYEYLEIGVDRTKLWLDVINEDLAKGVEDLNKIVKDLMDADKDFMNAVNENIQFFTDGFLIESVKGMINAIKNGDYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Q3</accession>
    <name>L0A8Q3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232151.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0487"/>
    <dbReference type="EnsemblBacteria" id="AFZ70253">
        <property type="protein sequence ID" value="AFZ70253"/>
        <property type="gene ID" value="Calag_0487"/>
    </dbReference>
    <dbReference type="GeneID" id="14211747"/>
    <dbReference type="KEGG" id="clg:Calag_0487"/>
    <dbReference type="eggNOG" id="arCOG00033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022610_0_0_2"/>
    <dbReference type="OMA" id="HYYDIQH"/>
    <dbReference type="OrthoDB" id="55502at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="3">
        <location>
            <begin position="11"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="271" mass="31504" checksum="535EF7F9E752FFAE" modified="2013-03-06" version="1">MIKAVWKKPKIEYIGDIAIIKPPFNYKNEDELKKLANEILEKNKYIKSVWLASSPVEGEFKTREYKHLAGEYRSETIYKEHGCSFKVDIRKVFITPRLSYEHLRIANLVKNGEIITNMFAGAGLFSIIIAKKSKPKLVHSIDINPYAYKYMVNNIDINKVNDIVIPYLGDSKEIIEEKLINSSDRVLMPLPEKALEYIKYAISAINKKGFIHIYLHINSKKDEDYLNLAENISKEELNKYNITYKIINSKEVRPVGPRLYQVVLDVYIEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8R3</accession>
    <name>L0A8R3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nucleic-acid-binding protein containing a Zn-ribbon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232161.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0497"/>
    <dbReference type="EnsemblBacteria" id="AFZ70263">
        <property type="protein sequence ID" value="AFZ70263"/>
        <property type="gene ID" value="Calag_0497"/>
    </dbReference>
    <dbReference type="GeneID" id="14211757"/>
    <dbReference type="KEGG" id="clg:Calag_0497"/>
    <dbReference type="eggNOG" id="arCOG01285">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119412_2_2_2"/>
    <dbReference type="OMA" id="IYYGTKF"/>
    <dbReference type="OrthoDB" id="120594at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="49"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="137" mass="15659" checksum="191A8BD21E1783A5" modified="2013-03-06" version="1">MSMDLSISRFWRKKEILYKLNGAKCKSCGKVHYPPKNACPYCGSRELEYIELPRKGKLISYTTIYAIPDGARPQSPIYFGLIDLGIAKITAELTDIIDPSILKKDMEVEATLRKTQEDRDAGLIYYVLKFRPSLVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8S6</accession>
    <name>L0A8S6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psmB</name>
        <name evidence="11" type="ordered locus">Calag_0514</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232176.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0514"/>
    <dbReference type="EnsemblBacteria" id="AFZ70278">
        <property type="protein sequence ID" value="AFZ70278"/>
        <property type="gene ID" value="Calag_0514"/>
    </dbReference>
    <dbReference type="GeneID" id="14211774"/>
    <dbReference type="KEGG" id="clg:Calag_0514"/>
    <dbReference type="eggNOG" id="arCOG00970">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_2_2"/>
    <dbReference type="OMA" id="RVSYGFY"/>
    <dbReference type="OrthoDB" id="89767at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03634">
        <property type="entry name" value="arc_protsome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7 9 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8 9" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005069133" description="Removed in mature form; by autocatalysis" evidence="9">
        <location>
            <begin position="1"/>
            <end position="7"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023231214" description="Proteasome subunit beta" evidence="9">
        <location>
            <begin position="8"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="207" mass="22611" checksum="FD587BE03C86DF56" modified="2013-03-06" version="1">MAISYEQGTALGIKAKDGVVLATDKRMSYGSFIMSRNAKKVYLLNDRVGIALTGLYADVSGLVRIMNAEISYYETTNETTMSLYAISKLFSNILYSYKMLPFLIESIIGGLDRDGKPKIYTLDALGSVTEDKYMAVGSGGTTALGVLEYSYNDNLTIDEAEKIAITALKTTMERDSSSGDGIDLLIIKSEGKPLEKSYKLKVVEEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8T4</accession>
    <name>L0A8T4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232186.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0526"/>
    <dbReference type="EnsemblBacteria" id="AFZ70288">
        <property type="protein sequence ID" value="AFZ70288"/>
        <property type="gene ID" value="Calag_0526"/>
    </dbReference>
    <dbReference type="GeneID" id="14211786"/>
    <dbReference type="KEGG" id="clg:Calag_0526"/>
    <dbReference type="eggNOG" id="arCOG04811">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152986_0_0_2"/>
    <dbReference type="OMA" id="YVFAANT"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="123" mass="13473" checksum="7668F3A2A9B764E0" modified="2013-03-06" version="1">MIEFLSTITVTNASTTQMFFNALHNPYELVTLLIEFFLGLGLGYVSIKILKYIIAFIVIVIIGVILNAWSFGGSLSKTISTLQSQAISLEPLLRNLMFTLGLLTMGPILLGFIIGILIGLARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8U6</accession>
    <name>L0A8U6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232201.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0543"/>
    <dbReference type="EnsemblBacteria" id="AFZ70303">
        <property type="protein sequence ID" value="AFZ70303"/>
        <property type="gene ID" value="Calag_0543"/>
    </dbReference>
    <dbReference type="GeneID" id="14211803"/>
    <dbReference type="KEGG" id="clg:Calag_0543"/>
    <dbReference type="HOGENOM" id="CLU_1922668_0_0_2"/>
    <dbReference type="OMA" id="PLYEFIS"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="131" mass="14724" checksum="F1B7C032924D9F69" modified="2013-03-06" version="1">MKLGILAIIAGLILIGLAVYPLYEFISGFTQHPLNITETQTTCNGTPGLLFNIKYNNEIEIYNASILLKLKYFNGSTSNNILFTGNLIPNETINKCIPIYYFENATKYEFTFAGKIANMYFFNLTEVNNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8V1</accession>
    <name>L0A8V1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM additional 4Fe4S-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231747.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0057"/>
    <dbReference type="EnsemblBacteria" id="AFZ69849">
        <property type="protein sequence ID" value="AFZ69849"/>
        <property type="gene ID" value="Calag_0057"/>
    </dbReference>
    <dbReference type="GeneID" id="14211317"/>
    <dbReference type="KEGG" id="clg:Calag_0057"/>
    <dbReference type="eggNOG" id="arCOG00940">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_0_2"/>
    <dbReference type="OMA" id="PVVIWNL"/>
    <dbReference type="OrthoDB" id="18533at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="32"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ69849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="397" mass="45085" checksum="AD4D81316025F43B" modified="2013-03-06" version="1">MIPITVMVTGEGTVSSKIKGHYNKDNPSTFTNELKPAVFWNITYKCNLNCVHCYIDASSKINREELSKEKLIEVANEIVKLELPLIVFTGGEPLYRKEFWDVSEVLANRKKPKLTLSTNGTLITEENAKKLKELGYMYIGISLDSIYPQNHDKFRGYDGAFSLTMKGIENSIKYGIDVGIRTTITKYNVNEIPAMIDFVVKKGIRRISLYLLDTIGRAVKISSDLPTKDQLISLTNILIEKAKEYKSKIEIEIVRGNFIGIYVADKISSNKEDFLKYLKMIQAQGDCGRKTISIYPDGTVRPCQFIDDYIIGDLRKQKLEEILQIANPNLEKFINLSENLEGERCSKCAFKKICGGGSRGRAKVINNNFWGDEPLCFIDYNDIAKRWGIIDSHSFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Y0</accession>
    <name>L0A8Y0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ69879">
        <property type="protein sequence ID" value="AFZ69879"/>
        <property type="gene ID" value="Calag_0091"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0091"/>
    <dbReference type="HOGENOM" id="CLU_3322760_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="38" mass="4565" checksum="FA1C641807338B45" modified="2013-03-06" version="1">MIYHKINSAEIKEKLNKELLSLTNKFINNLLYIKFIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0A902</accession>
    <name>L0A902_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232239.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0583"/>
    <dbReference type="EnsemblBacteria" id="AFZ70341">
        <property type="protein sequence ID" value="AFZ70341"/>
        <property type="gene ID" value="Calag_0583"/>
    </dbReference>
    <dbReference type="GeneID" id="14211843"/>
    <dbReference type="KEGG" id="clg:Calag_0583"/>
    <dbReference type="eggNOG" id="arCOG01668">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138323_0_0_2"/>
    <dbReference type="OMA" id="FMWATNA"/>
    <dbReference type="OrthoDB" id="115682at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="119" mass="13275" checksum="77822AB7D77C3F35" modified="2013-03-06" version="1">MGSQLKVLVILSSSDIDKILTGLLWSTNAFKYKWVSDLKLVFFGPSEKFLSLKDKRVLDALKQFLSYANQKPLACKFLAEQDGTLNELQTVSSELGIDVVYVGSKISSYLSEGYVPLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0A925</accession>
    <name>L0A925_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0638"/>
    <dbReference type="EnsemblBacteria" id="AFZ70393">
        <property type="protein sequence ID" value="AFZ70393"/>
        <property type="gene ID" value="Calag_0638"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0638"/>
    <dbReference type="eggNOG" id="arCOG13730">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2550042_0_0_2"/>
    <dbReference type="OMA" id="PYTLMEL"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="85" mass="9928" checksum="DA81F4A01A2F9FC0" modified="2013-03-06" version="1">MKKMRAHDALRKTFLKFNVQADPYTLMELESFVIISRNKDKNNKNYQSLVSNLELVLTRQEIDNAKDISKKMADFILDLCKDGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A938</accession>
    <name>L0A938_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232306.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0657"/>
    <dbReference type="EnsemblBacteria" id="AFZ70408">
        <property type="protein sequence ID" value="AFZ70408"/>
        <property type="gene ID" value="Calag_0657"/>
    </dbReference>
    <dbReference type="GeneID" id="14211917"/>
    <dbReference type="KEGG" id="clg:Calag_0657"/>
    <dbReference type="eggNOG" id="arCOG00458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108521_2_0_2"/>
    <dbReference type="OMA" id="NAYNINR"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11375">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012962">
        <property type="entry name" value="Pept_M54_archaemetzincn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012091">
        <property type="entry name" value="Pept_M54_archaemetzncn_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910">
        <property type="entry name" value="PTHR15910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07998">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005785">
        <property type="entry name" value="Zn-prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="183" mass="21823" checksum="3F4D22B21B7838F9" modified="2013-03-06" version="1">MIEILLQPIGDINLDDVDYIIQNIPNHFPFEIKIYPHLWSLQPPFNAYNINRMQYDAEIINKFLYDKYKEFLSKKSNFVLGVSMLDGYYFNLNFVFGLANIEMKVASIYTKRLKNFDQLKYRERILKESIHEIGHLFGLKHCNTYKCVMNFSNSVDDVDNKNPDFCDRCKLDIMQFYESTLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0A951</accession>
    <name>L0A951_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Calag_0674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232321.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0674"/>
    <dbReference type="EnsemblBacteria" id="AFZ70423">
        <property type="protein sequence ID" value="AFZ70423"/>
        <property type="gene ID" value="Calag_0674"/>
    </dbReference>
    <dbReference type="GeneID" id="14211934"/>
    <dbReference type="KEGG" id="clg:Calag_0674"/>
    <dbReference type="eggNOG" id="arCOG00312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_21_3_2"/>
    <dbReference type="OMA" id="WWPKDFT"/>
    <dbReference type="OrthoDB" id="98508at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="195" mass="22219" checksum="F6047A4E5516F8F2" modified="2013-03-06" version="1">MIDVGVQAPEFKSRAYFPAENKVKEIKLSDYKGKWVILTFHPGDFTFVCATDLEAFQAYYEKFKENNAEVLGISTDSVYSHKVWVETSPRVKNVKFPLVDDIKKEISTAYGFLNPNSGMTRRGTVIINPEGIVEYVSVFNDRLGKDVPHIYNAFINLKYLYEHPAKPEEFDIIAANKGEGFQTIRIRIPDSIGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0A964</accession>
    <name>L0A964_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0693"/>
    <dbReference type="EnsemblBacteria" id="AFZ70438">
        <property type="protein sequence ID" value="AFZ70438"/>
        <property type="gene ID" value="Calag_0693"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0693"/>
    <dbReference type="eggNOG" id="arCOG00193">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="QSIVTFP"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="225" mass="25359" checksum="87B6D6CEA023D532" modified="2013-03-06" version="1">MEVRENQIVSIIGPSGVGKSTLLRVLGGFLKPTQGSVYLLGQKITRPTPKIMLVHQSIVTFPWMTALENVMLGLKHRNLPKNTMKEIAKQMLETVGLEGFENFYPKELSGGMRQRVAIARALAADPLLLLMDEPFAHLDELTAESLRKELYDILFNVNTTLKGVVLVSHNLNEVVELSDFVYIINGHPATVVGKVKIDLERPRNPRDPKFFEYTDILYDYTIPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9B7</accession>
    <name>L0A9B7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232390.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0749"/>
    <dbReference type="EnsemblBacteria" id="AFZ70493">
        <property type="protein sequence ID" value="AFZ70493"/>
        <property type="gene ID" value="Calag_0749"/>
    </dbReference>
    <dbReference type="GeneID" id="14212009"/>
    <dbReference type="KEGG" id="clg:Calag_0749"/>
    <dbReference type="eggNOG" id="arCOG12513">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1736327_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="SSF143870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="150" mass="17146" checksum="E2666B926323DA98" modified="2013-03-06" version="1">MKVIKLTYPFDEIFLIKIDDVSIDKKLLANLTKKFQPYTLIFSTPHDIEPCVIALVYTYVLEDIKYDSKISNISLKALLYLTKSKQISDAIESSRNFNGLAIVSINKQGIIDALKEIGYEIDNIEEETYNCKNLDGLTDITAYRLNELNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9C5</accession>
    <name>L0A9C5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0147 protein Calag_0242</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0147 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231922.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0242"/>
    <dbReference type="EnsemblBacteria" id="AFZ70024">
        <property type="protein sequence ID" value="AFZ70024"/>
        <property type="gene ID" value="Calag_0242"/>
    </dbReference>
    <dbReference type="GeneID" id="14211502"/>
    <dbReference type="KEGG" id="clg:Calag_0242"/>
    <dbReference type="eggNOG" id="arCOG04308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165882_0_0_2"/>
    <dbReference type="OMA" id="RTIIWEV"/>
    <dbReference type="OrthoDB" id="116790at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00342">
        <property type="entry name" value="UPF0147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023130">
        <property type="entry name" value="Ta0600-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005354">
        <property type="entry name" value="UPF0147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03685">
        <property type="entry name" value="UPF0147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="89" mass="9811" checksum="704167714033A516" modified="2013-03-06" version="1">MSVQASTEEKLKMAINILTGIINDTAVPRNIRRAAANALTYLRDTKLSAGVKAANAISSLDEISQDPNMPFHARTRIWQVLSMLETIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9C7</accession>
    <name>L0A9C7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232373.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70476">
        <property type="protein sequence ID" value="AFZ70476"/>
        <property type="gene ID" value="Calag_0732"/>
    </dbReference>
    <dbReference type="GeneID" id="14211992"/>
    <dbReference type="KEGG" id="clg:Calag_0732"/>
    <dbReference type="eggNOG" id="arCOG07493">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2379217_0_0_2"/>
    <dbReference type="OMA" id="MMYEIEM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="102" mass="11556" checksum="67FC2F702DFBE444" modified="2013-03-06" version="1">MSTIIKDILVYFEEQGPMSPGDVAQKLNVPRYKVLATIQCLSELGFLESLYSRGSYKIYQISLLGKNALERLKSEESLRDILEESLMNENLLKNNEKGKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9D3</accession>
    <name>L0A9D3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4382 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232405.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70508">
        <property type="protein sequence ID" value="AFZ70508"/>
        <property type="gene ID" value="Calag_0764"/>
    </dbReference>
    <dbReference type="GeneID" id="14212024"/>
    <dbReference type="KEGG" id="clg:Calag_0764"/>
    <dbReference type="eggNOG" id="arCOG06011">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1599091_0_0_2"/>
    <dbReference type="OMA" id="YNEVFFT"/>
    <dbReference type="OrthoDB" id="95332at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025491">
        <property type="entry name" value="DUF4382"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14321">
        <property type="entry name" value="DUF4382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4382" evidence="2">
        <location>
            <begin position="35"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="175" mass="18604" checksum="60999EEA7092ED1C" modified="2013-03-06" version="1">MQRGIGKGAILGIVIIIIVIGLVAGLYYYYYGPSGKVYVYLSDPGNTSFVNIYFTITSIQAHSTKGWITISNKTETVSLSSTPQLITSANMPPGNYTEVRFVVQSVTITLANNFNVSATLPSNVFKVPIIGGLDIKPGGTEYLTISIGPHVTLTGNGSYILRPLIIASASNTPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9E4</accession>
    <name>L0A9E4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S oxidoreductase, coproporphyrinogen III oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0776</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232415.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0776"/>
    <dbReference type="EnsemblBacteria" id="AFZ70518">
        <property type="protein sequence ID" value="AFZ70518"/>
        <property type="gene ID" value="Calag_0776"/>
    </dbReference>
    <dbReference type="GeneID" id="14212036"/>
    <dbReference type="KEGG" id="clg:Calag_0776"/>
    <dbReference type="eggNOG" id="arCOG07424">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_3_1_2"/>
    <dbReference type="OMA" id="CHTLCSF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="27"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="405" mass="47449" checksum="B5ECDD88162F93DB" modified="2013-03-06" version="1">MIIENVIKYIFHNYNWHLENYSAKEPEECIDCKALYIHVPFCSSLCPFCIFHSVLYNKNLVKDYFDSMKKEIDKYIDKNYNFESIYIGGGTPTLTTSEVCDLIDYVKNYYKIKEISIEGSIQDISDEKVNTLKECGTTRLSLGVEAIQPSIQKSIGRANIDEEEILSKIDMASKIKTLNVDILFNLPNQTINDLGYEIEKIKDSKANQLTFYPIMPSIRNNNLNKEIDESKEKQFYFYIMKNFVNSYFYQSNAWTYSKGSDFITDEYIVDYPYFAGIGTGAMSYINGKYLVNSFNINKYEKLISKNSMPTILSKDLSLKEQVYLEFIYKFYSFNIDNDTFEKLFGANIENYMKEELYLLYLINAIKKDSNKIVITDYGKYIANLLMKYFYINVSKIRKYCIENNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9K4</accession>
    <name>L0A9K4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231715.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0022"/>
    <dbReference type="EnsemblBacteria" id="AFZ69817">
        <property type="protein sequence ID" value="AFZ69817"/>
        <property type="gene ID" value="Calag_0022"/>
    </dbReference>
    <dbReference type="GeneID" id="14211283"/>
    <dbReference type="KEGG" id="clg:Calag_0022"/>
    <dbReference type="eggNOG" id="arCOG00016">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1021571_0_0_2"/>
    <dbReference type="OMA" id="IRRICCE"/>
    <dbReference type="OrthoDB" id="98664at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="262" mass="29836" checksum="689028E985713FA0" modified="2013-03-06" version="1">MVCNALIISSPTVDIININNNEVICAGGPPLYAGFALRKMNCNVYFYGPIGYETEKTVNLQEKINIITVGIRQKVKGAVFYHKYNQDKRLTKFIGEIIPIDVNDLINKTRNIKFDFIILSPIFNEIPAEQIKLLNKPIVLDPQGYVRSLKAWMDLVPLNYIDLFHISSDDLPLDLVKNLAINSILLYTMGIENTVIIDKNEAKEIKPSGNIAKDRTGSGDIITGLVSYYYFYKKLNIVDAYNKAQENFEEVINEVNRIKYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9S2</accession>
    <name>L0A9S2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Box A-binding protein</fullName>
            <shortName evidence="6">BAP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">TATA sequence-binding protein</fullName>
            <shortName evidence="6">TBP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">TATA-box factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tbp</name>
        <name evidence="8" type="ordered locus">Calag_0393</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0393"/>
    <dbReference type="EnsemblBacteria" id="AFZ70164">
        <property type="protein sequence ID" value="AFZ70164"/>
        <property type="gene ID" value="Calag_0393"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0393"/>
    <dbReference type="eggNOG" id="arCOG01764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060161_4_3_2"/>
    <dbReference type="OMA" id="NCEYEPE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04518">
        <property type="entry name" value="TBP_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033711">
        <property type="entry name" value="TBP_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="PTHR10126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="1" evidence="6">
        <location>
            <begin position="31"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="6">
        <location>
            <begin position="122"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="209" mass="23568" checksum="9F63F85412104604" modified="2013-03-06" version="1">MEHEKKEDEEFFGEEKTMDEKEEFGKPTVKIENIVATVILDTPLDLNLIETRIPDVDYNPDQFPGLVYRLQSPKITALIFKSGKMVVTGAKSVKQLVWAVKTILKKLMIKGVPMQGKPQIQIQNIVASANLNVDVDLEKAAFTLPKSMYEPEQFPGLIYRMEKPRVVLLIFSSGKMVITGAKRESEVQDAVNGIYNILKGNKSIKEDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9S4</accession>
    <name>L0A9S4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">30S ribosomal protein S27e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps27e</name>
        <name evidence="4" type="ordered locus">Calag_0398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232067.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0398"/>
    <dbReference type="EnsemblBacteria" id="AFZ70169">
        <property type="protein sequence ID" value="AFZ70169"/>
        <property type="gene ID" value="Calag_0398"/>
    </dbReference>
    <dbReference type="GeneID" id="14211658"/>
    <dbReference type="KEGG" id="clg:Calag_0398"/>
    <dbReference type="eggNOG" id="arCOG04108">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199465_0_0_2"/>
    <dbReference type="OMA" id="DCENEQV"/>
    <dbReference type="OrthoDB" id="129447at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_S27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_S27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="69" mass="7566" checksum="6EA35D934DB2A3EF" modified="2013-03-06" version="1">MKSSLLRNRLLVPQPRSRFLIVECPNCGHKQIVYSHSSFSARCLSCGALLVKPTGGKAQILGKVEKILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9V5</accession>
    <name>L0A9V5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231820.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0134"/>
    <dbReference type="EnsemblBacteria" id="AFZ69922">
        <property type="protein sequence ID" value="AFZ69922"/>
        <property type="gene ID" value="Calag_0134"/>
    </dbReference>
    <dbReference type="GeneID" id="14211394"/>
    <dbReference type="KEGG" id="clg:Calag_0134"/>
    <dbReference type="eggNOG" id="arCOG00249">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010448_2_1_2"/>
    <dbReference type="OMA" id="MNPPVLM"/>
    <dbReference type="OrthoDB" id="24701at2157"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="7">
        <location>
            <begin position="7"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="6">
        <location>
            <begin position="183"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="6">
        <location>
            <begin position="299"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ69922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="651" mass="73660" checksum="9BC955253125F06A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9X4</accession>
    <name>L0A9X4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0064"/>
    <dbReference type="EnsemblBacteria" id="AFZ69855">
        <property type="protein sequence ID" value="AFZ69855"/>
        <property type="gene ID" value="Calag_0064"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0064"/>
    <dbReference type="eggNOG" id="arCOG00239">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_2"/>
    <dbReference type="OMA" id="FESYAEL"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="257" mass="29088" checksum="DD40791342B1E154" modified="2013-03-06" version="1">MKSGDIMIKVEKYDDEKYAIIAISRPEKLNAINFQTGYELVQKLREVNENPNIRTVIITGEGRAFCSGADVSEEVEDIGRDLKLSFHPIIKEIRFSNKIYIAAINGVVAGACIGIVLSTDFRYAKKETRFITAFQRIGLAPDTGVAYFLLKHVKDQKAYELTVLGGEFSAEDAEKWGLLKIVEDPLQEAKKFAKMIANGPFQSYIGGKKQANFVLYSDLERFLDYELSIQEYVGTTKDFREGVLSFREKREPKFKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA02</accession>
    <name>L0AA02_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lactate dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231860.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0177"/>
    <dbReference type="EnsemblBacteria" id="AFZ69962">
        <property type="protein sequence ID" value="AFZ69962"/>
        <property type="gene ID" value="Calag_0177"/>
    </dbReference>
    <dbReference type="GeneID" id="14211437"/>
    <dbReference type="KEGG" id="clg:Calag_0177"/>
    <dbReference type="eggNOG" id="arCOG01754">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_2"/>
    <dbReference type="OMA" id="GWHPTQM"/>
    <dbReference type="OrthoDB" id="36410at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="120"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ69962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="339" mass="38102" checksum="400B6D9024E5347F" modified="2013-03-06" version="1">MEEESNVVAFGPLPKAFYQSLFEPYANKLQKKVNIEVFSDLTNMDKIKDALQKADVILGDHTMKIKIDKSLCEMFGPRVKLLQQPSTGFDHIDIEACKQKGIPVANIGSANSLSVAEYAIMVALSLLKRLILANNSIKEGKWYQWELMDMGTYDLYGKSWGIIGMGRIGKELAKRLIPFNVKVFYYDKVRLNENDEKNLNVTFKPINQILRDSDIISLHVPLTNETRKMITMRELRMMKPSSILINASRGELIDNEALANALQNGIIAGAAIDVFDKEPPDINHPLISLSRKNPNVNLILTPHIAGANTDTRMRIIQVSIENVIRVLLGQKPENVVNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA06</accession>
    <name>L0AA06_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1011"/>
    <dbReference type="EnsemblBacteria" id="AFZ70733">
        <property type="protein sequence ID" value="AFZ70733"/>
        <property type="gene ID" value="Calag_1011"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1011"/>
    <dbReference type="HOGENOM" id="CLU_1922670_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="131" mass="15137" checksum="C5672060668F4DB6" modified="2013-03-06" version="1">MIEGSVTSYVKQQNKVIVYLSNGKSIEYENAELYITKKRINFIRAIFSLIFFSLISFSIIYYLPPWKLYGLKPGIQFAFSLALFAILVASLYSIYISADSLRKYPILIIKLNGEIHEYLLLSKYKNQESKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-12-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA33</accession>
    <name>L0AA33_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DhnA-type fructose-1,6-bisphosphate aldolase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1041"/>
    <dbReference type="EnsemblBacteria" id="AFZ70763">
        <property type="protein sequence ID" value="AFZ70763"/>
        <property type="gene ID" value="Calag_1041"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1041"/>
    <dbReference type="eggNOG" id="arCOG04044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057069_2_2_2"/>
    <dbReference type="OMA" id="FVKVNYP"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="278" mass="30876" checksum="0D2AE9747634323F" modified="2013-03-06" version="1">MSKYEGTSYSNVGIKVRLSRILKNDRAVIFAFDHGLEHGPRDFMEDRYMAKTILEKVVNAGVDAMMLLPGMARLTYDIWKNKVALIIKLTGKSDIRPQDKHYLQSSLGSVEQAISLGADAVAATVYWGSDYEDEMISHWYEIKESATYYGMPVLQLAYPRGSAIKNRYDPEIVMYGARAAAETGADLIKTYYTGNKETFAKVVEMAQGLPVVMSGGAVRDKPIEFLEDVYNVIQAGGSGVAVGRNVFRSNNIEGMVRAVMKVVHENALPEEAVKELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA46</accession>
    <name>L0AA46_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232628.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1009"/>
    <dbReference type="EnsemblBacteria" id="AFZ70731">
        <property type="protein sequence ID" value="AFZ70731"/>
        <property type="gene ID" value="Calag_1009"/>
    </dbReference>
    <dbReference type="GeneID" id="14212269"/>
    <dbReference type="KEGG" id="clg:Calag_1009"/>
    <dbReference type="eggNOG" id="arCOG03413">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1615228_0_0_2"/>
    <dbReference type="OMA" id="LYAGPGC"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="4">
        <location>
            <begin position="60"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="164" mass="18304" checksum="51E46DD9A3CE18C7" modified="2013-03-06" version="1">MAGLPKEIISNLYAGPGCIDLEKFNINADLIITLDPSCVVRGNNNRIVLPIEDFDVEPIINIGKAVEIIENNLKKGKKIYVHCHAGCGRTGTVIVSYLILYKDMQLNYALDLFYSKRGCGPDSMPQELFLESLYKLKRKVGSNNLVVKALLKSETLDDFLSNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA58</accession>
    <name>L0AA58_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Orotidine-5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="2">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232643.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1024"/>
    <dbReference type="EnsemblBacteria" id="AFZ70746">
        <property type="protein sequence ID" value="AFZ70746"/>
        <property type="gene ID" value="Calag_1024"/>
    </dbReference>
    <dbReference type="GeneID" id="14212284"/>
    <dbReference type="KEGG" id="clg:Calag_1024"/>
    <dbReference type="eggNOG" id="arCOG00081">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067069_2_0_2"/>
    <dbReference type="OMA" id="EMSHPGA"/>
    <dbReference type="OrthoDB" id="54384at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="PTHR32119:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="223" mass="24904" checksum="543B940E761CA244" modified="2013-03-06" version="1">MTLIVAIDRSNTTDGRDVIEVLEKICNMVAGVKLGMPLLLKHDLNLLLNIRKICNNNIILDLKLADIGDIMVETAELFKNYADSIIAHSFIGKKDGIDKLKNFLDKNNMKLILVGSMSHMGSEEIYDKEINNIINIIKDVNPWGVVLPATRPEIIRTFRSKIGNEIKILSPGIGYQGAKPGTALCYGADYEIVGRSIMNAPDPKEATKVIIYEQKRGMYECKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA77</accession>
    <name>L0AA77_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232227.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0570"/>
    <dbReference type="EnsemblBacteria" id="AFZ70329">
        <property type="protein sequence ID" value="AFZ70329"/>
        <property type="gene ID" value="Calag_0570"/>
    </dbReference>
    <dbReference type="GeneID" id="14211830"/>
    <dbReference type="KEGG" id="clg:Calag_0570"/>
    <dbReference type="eggNOG" id="arCOG01603">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_2_0_2"/>
    <dbReference type="OMA" id="KWGQAIP"/>
    <dbReference type="OrthoDB" id="95610at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011894">
        <property type="entry name" value="PorC_KorC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02175">
        <property type="entry name" value="PorC_KorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="11"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="186" mass="19846" checksum="CDB1905E9795A059" modified="2013-03-06" version="1">MYLELRFHGRGGEGAVTAATILARAAVLENKYAQAIPNFSAERRGAPVEVYSRISDKPIEKHSQVRNPDAVIVLDYELIKMVNVLDGLKPNGIAIVNSPVKEPLNNVKTYCVDATKIAKAHNLVVSGWPTVNTAILGAVSKSLGIVSIDSISKAIMDHFSSPNIAKANASAAIDAYKETSLCGGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAA0</accession>
    <name>L0AAA0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MoaD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231945.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0266"/>
    <dbReference type="EnsemblBacteria" id="AFZ70047">
        <property type="protein sequence ID" value="AFZ70047"/>
        <property type="gene ID" value="Calag_0266"/>
    </dbReference>
    <dbReference type="GeneID" id="14211526"/>
    <dbReference type="KEGG" id="clg:Calag_0266"/>
    <dbReference type="eggNOG" id="arCOG00536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_1_2_2"/>
    <dbReference type="OrthoDB" id="119587at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010038">
        <property type="entry name" value="MoaD_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01687">
        <property type="entry name" value="moaD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="95" mass="10719" checksum="AF7092ED29151984" modified="2013-03-06" version="1">MKIKVLTMGTLYMITKKFETEIEFKQKPKLIDVINYMIENNPKIKDQIMSQGKLVDNVSILINGREYRYMDEGINTGLKDGDVIAIVPPAGGGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAA1</accession>
    <name>L0AAA1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonic acid semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231868.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0186"/>
    <dbReference type="EnsemblBacteria" id="AFZ69970">
        <property type="protein sequence ID" value="AFZ69970"/>
        <property type="gene ID" value="Calag_0186"/>
    </dbReference>
    <dbReference type="GeneID" id="14211446"/>
    <dbReference type="KEGG" id="clg:Calag_0186"/>
    <dbReference type="eggNOG" id="arCOG01252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_10_2"/>
    <dbReference type="OMA" id="HGKRAQC"/>
    <dbReference type="OrthoDB" id="56373at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="21"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="499" mass="55865" checksum="CB636354BF84FB37" modified="2013-03-06" version="1">MELHIVKNFIDNAYHEAISDKYYDVYNPAFGEVIARVPETPREEIDRAIESSVNAFERWSKVPVTERIKYLFRLHELIQNNIDEIAKTTTNEHGKIFNESKGDVIRTLENIEAASAEVYHMMGKNNTEIATNIDEFMIRVPIGVFAIISPFNFPLMVPFWFVPYAVATGNTVIVKPSEKTPLSMELVGELIRKAGFPEGVINIINGGSDVVNRLLDSKEIKGVGFVGTTGVAQYVYKKASESYKRVIANGSAKNFAIVMPDANLSQTIPNLISSFFGNAGERCLANSVLITFKENHDKVVSEFARASSKIRLGYGLDKDVDMGPLIREEHRQKVKSYIDYGKENKIKLIIDGSDKVPEKYKKGFFLGPTIFDEVPLDSKLIKEEIFGPVASVIVVDNFDEALNIINSSKYGNAGSIFTESGYYARRFANEVNAGNIGINIGIAAPLGYYPFGGMKDSFFGMLHAQGGEDHIMFYTERKIIINRWFGYSEKEKETPTTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAA6</accession>
    <name>L0AAA6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1079"/>
    <dbReference type="EnsemblBacteria" id="AFZ70801">
        <property type="protein sequence ID" value="AFZ70801"/>
        <property type="gene ID" value="Calag_1079"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1079"/>
    <dbReference type="eggNOG" id="arCOG01377">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024306_1_0_2"/>
    <dbReference type="OMA" id="IPGRFYI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="441" mass="51496" checksum="F724276F81EC7B5D" modified="2013-03-06" version="1">MLGLDSLPPKVLYENYGKGLDFIREIIKDSQNYLMKTCHPPITVPAWISMFTGKTPGELGIYGFRHRKPGTFDSYIVNSNDVKEKAIWDDLGKKGLKMGLFGVPPTYPPKPINGFMITDFNTPSKEKPYSFPPWIKNELQNNLKEEPIFDVVYRTEDRDKAYNDLMEMIDNHQRILNYLVKKSWDLFLYVEIGVDRAHHMFWKYFDNSHPRYEYHEKYSNAIPTVYKKIDNWFSNLIKQLPKDTIYVIVSDHGTKSMIGSYPINQWLIEQGFLKLKKEVNNEGTDLTFDIIDWNETKVWAWGGYYSRFFFNIKGREPHGIIEKEEVEGLVKDIKNSINKIKGPNNENWKNEAYLPQEIYPVSKGDAPDLTVYLDDLNWRPIGTIGYKSMYLEKNDKGPDDSMHDWYGVFSIYDPEGTLKKGNMGVIEINKIRQVLEELVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAF3</accession>
    <name>L0AAF3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl30</name>
        <name evidence="4" type="ordered locus">Calag_1172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1172"/>
    <dbReference type="EnsemblBacteria" id="AFZ70893">
        <property type="protein sequence ID" value="AFZ70893"/>
        <property type="gene ID" value="Calag_1172"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1172"/>
    <dbReference type="eggNOG" id="arCOG04086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055156_6_0_2"/>
    <dbReference type="OMA" id="KDYITWG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_A">
        <property type="entry name" value="Ribosomal_L30_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005997">
        <property type="entry name" value="Ribosomal_L30_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_L7/L30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_L7_euk_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="PTHR11524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01309">
        <property type="entry name" value="uL30_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="3">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="160" mass="18120" checksum="2C7AE56E19E20CC5" modified="2013-03-06" version="1">MIILVYAIIRIRGSSGLDPKVEKVLDLLRLRRNFVAVLYAENLNGLKNMLIEGQSAITWGEVNKETLAELIKRRGRIVGDKPITDQVVKEKLGLNGIEELADKIIKEEIHYNKLEEKGIKPFFRLHPPSGGFDLSIKRLYPKGELGYRGKAINDLILKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAG1</accession>
    <name>L0AAG1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1183"/>
    <dbReference type="EnsemblBacteria" id="AFZ70903">
        <property type="protein sequence ID" value="AFZ70903"/>
        <property type="gene ID" value="Calag_1183"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1183"/>
    <dbReference type="eggNOG" id="arCOG00017">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133047_2_1_2"/>
    <dbReference type="OMA" id="DYSCPYD"/>
    <dbReference type="OrthoDB" id="124843at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="133" mass="15252" checksum="8C614ADA7AF00093" modified="2013-03-06" version="1">MSKEKSIEEQTTIEMPCEVAARIVIPSIRASVAYILVNEFKLSKYTAARLLGLTPAAINNYISGKRGDRYMKILTEDEKYLEKVREAARLILAYQGRTEESMDEFMKKYQIAMCSICSEVNEVAHKYGCPYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAI2</accession>
    <name>L0AAI2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232337.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0694"/>
    <dbReference type="EnsemblBacteria" id="AFZ70439">
        <property type="protein sequence ID" value="AFZ70439"/>
        <property type="gene ID" value="Calag_0694"/>
    </dbReference>
    <dbReference type="GeneID" id="14211954"/>
    <dbReference type="KEGG" id="clg:Calag_0694"/>
    <dbReference type="eggNOG" id="arCOG01475">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_3_2"/>
    <dbReference type="OMA" id="CHQIRSR"/>
    <dbReference type="OrthoDB" id="110591at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="205"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="390" mass="43575" checksum="26B0A9007FB6DD3B" modified="2013-03-06" version="1">MVNFSEGKKRSLIASFMYMILSLFKISLGYKFSSLVIVADGIHNIADILTGFAVYIGLFFAEKYPSEKFPFGLYKAENLASLFIAFAIAYAGYEIIMEFLFSKQGKIFMPFLLITIELISAIVTYWLTRYLISTPGIKLDAINAEGVHAFQDALTSIAVIIGVLGEWFSIKYLPLIIGIGIGVYILYQSYQIGRDSILTLLDMGDEKMMENIKNIVSNIEGVIGVHEIKVRKAGPFYFASMHLEAPPALSVKDADKLADIVEEKLRRALPSLLYVSIHVEPGSYTGKWKLALLEDENDSLADEISKVKKIKILDTQNKNIESIINDINLKQGNMSIISSMLKEKGVNAIIYAGKEKLLSLKAYGIEVYHTSEKDEKKVIDLFKEGKLNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAJ0</accession>
    <name>L0AAJ0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit Rpo6</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpo6</name>
        <name evidence="3" type="synonym">rpoK</name>
        <name evidence="4" type="ordered locus">Calag_1214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232830.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1214"/>
    <dbReference type="EnsemblBacteria" id="AFZ70933">
        <property type="protein sequence ID" value="AFZ70933"/>
        <property type="gene ID" value="Calag_1214"/>
    </dbReference>
    <dbReference type="GeneID" id="14212474"/>
    <dbReference type="KEGG" id="clg:Calag_1214"/>
    <dbReference type="eggNOG" id="arCOG01268">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112527_2_2_2"/>
    <dbReference type="OMA" id="KIGPPWL"/>
    <dbReference type="OrthoDB" id="126193at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="95" mass="10572" checksum="514F852F71596B43" modified="2013-03-06" version="1">MSGSYMAYPKIREDIIIGPPYLTKYEKAKIIGIRSLQLTKNAPPLIKLDVVKSSDPVSIAKYEVENGILPVSIIRYTQSGLKQVIPLKLLLESTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAL5</accession>
    <name>L0AAL5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RecA-superfamily ATPase possibly involved in signal transduction</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231978.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0301"/>
    <dbReference type="EnsemblBacteria" id="AFZ70080">
        <property type="protein sequence ID" value="AFZ70080"/>
        <property type="gene ID" value="Calag_0301"/>
    </dbReference>
    <dbReference type="GeneID" id="14211561"/>
    <dbReference type="KEGG" id="clg:Calag_0301"/>
    <dbReference type="eggNOG" id="arCOG01174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046233_0_0_2"/>
    <dbReference type="OrthoDB" id="55361at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="458" mass="52069" checksum="AAFF8B7F0642E285" modified="2013-03-06" version="1">MQEYQGNSTTSLSNFIGPIKKGNVILIVGNPGAGKTIIASKLSLDEIVNNGGSVLYLNMSEVKKDYFKNLKILGVDFEKLENENKFYYIEGITLVNKDSVYELLNQILSYSEKYNVSMVVIDSVTPIFQAFGNEVEVRELIHNFFYRLSKLSNKTLILTEEIPYGEEKFGYGVEEFIVDVIIQLKVLNVKGRIVRVMEIKKFRGSDISIGDIPFRIKSGELISLLYFKTHNQKSSDTIYKVGLGDATFAFYKGTQNLIMVDPKIDREGLIFLGIYGALLGNPFLQSGKEKTIIRVISSDIDKFKKKLNECLNSMSLGKDVIENIMNNIYVLGMDLDIFSLNDYFDVINEQEENIKPAIIIDLTLDLAYNLLGDQQLFNMLQLNLINKRSSNSITGLYIVNGKYKDIYSFPLVSLYDNIAYVKHYKNSGILVKPVKMEYRLFTLESFVINKEMVGKCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAP9</accession>
    <name>L0AAP9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232858.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1244"/>
    <dbReference type="EnsemblBacteria" id="AFZ70961">
        <property type="protein sequence ID" value="AFZ70961"/>
        <property type="gene ID" value="Calag_1244"/>
    </dbReference>
    <dbReference type="GeneID" id="14212504"/>
    <dbReference type="KEGG" id="clg:Calag_1244"/>
    <dbReference type="eggNOG" id="arCOG00246">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045401_2_1_2"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="OrthoDB" id="69007at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01339">
        <property type="entry name" value="LDH-like_MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011275">
        <property type="entry name" value="Malate_DH_type3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="7">
        <location>
            <begin position="145"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="308" mass="32876" checksum="949636DCC2DB4D6A" modified="2013-03-06" version="1">MITVVGGAGKVGATTGAFLLMRDVDDVVLIDILKDKPQGEALDLGHMASAIGSSRKVIGSNDYKDMAGSDIVIITAGFPRKAGQTREELLAINAKVMAEVSDAIKEYAPKAKVLVLTNPSDAMTYVVYKRLKAPRSQVIGFSGLLDAPRLSYYASQKLGISPASILPIVLGMHGENMFPVPRLSMVGGVPLSELMTKDQIDDIVKKTVSAGAEVIKLRGYSSNWAPAAGLTLMAEAIKNDQKRAIIASVILQGEYGVNDVVAEVPVILGKNGVEKVLEVPLNDEERQGFMKSIDAVRALLNSLPPEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAQ7</accession>
    <name>L0AAQ7_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CdvA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0766"/>
    <dbReference type="EnsemblBacteria" id="AFZ70509">
        <property type="protein sequence ID" value="AFZ70509"/>
        <property type="gene ID" value="Calag_0766"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0766"/>
    <dbReference type="eggNOG" id="arCOG04054">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100857_0_0_2"/>
    <dbReference type="OMA" id="MIAVKMS"/>
    <dbReference type="OrthoDB" id="48352at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041461">
        <property type="entry name" value="CdvA_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18822">
        <property type="entry name" value="CdvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CdvA" evidence="3">
        <location>
            <begin position="91"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="240" mass="27277" checksum="63BE50D4B88894E0" modified="2013-03-06" version="1">MSTLAILKIDEISRYTGDDINDEYGRILGTIISVQSSVDGRVESVTIKVADRYLETIEGERIKIHDGKLVVIPNWKFEASRIIENLDRAYKRRKALDTISGQNDLPSSVVEPMKRRLEEEIKALRIKADEVKKIINGRVGEIEDEELKVAKAIATIEISYFSGEVGEKGYTQSMNHLRKLKESISEEKRNAKEYLEKLDKTIQLTFTENKEVVKPKESEENKISQVPQSNQGSLIVKIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAR3</accession>
    <name>L0AAR3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome bd-type quinol oxidase, subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Calag_0439</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0439"/>
    <dbReference type="EnsemblBacteria" id="AFZ70207">
        <property type="protein sequence ID" value="AFZ70207"/>
        <property type="gene ID" value="Calag_0439"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0439"/>
    <dbReference type="eggNOG" id="arCOG02721">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030555_3_3_2"/>
    <dbReference type="OMA" id="MISSTWI"/>
    <dbReference type="OrthoDB" id="20297at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="553" mass="61735" checksum="C911565FEAC76A27" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAS5</accession>
    <name>L0AAS5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1270"/>
    <dbReference type="EnsemblBacteria" id="AFZ70986">
        <property type="protein sequence ID" value="AFZ70986"/>
        <property type="gene ID" value="Calag_1270"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1270"/>
    <dbReference type="eggNOG" id="arCOG04266">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162442_0_0_2"/>
    <dbReference type="OMA" id="CPYYDKR"/>
    <dbReference type="OrthoDB" id="116348at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="97" mass="11620" checksum="A20B0C3F1AF7D9C3" modified="2013-03-06" version="1">MSEPKQTNDQDVRKKWITKMIKSAKNQYKLCPYFDKKTVQCFLMLTMKNKHAKCDRDGRFDNCPLFLEYLDQVYENISKNKKTLPNNFQDILTSYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAT1</accession>
    <name>L0AAT1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232426.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0787"/>
    <dbReference type="EnsemblBacteria" id="AFZ70529">
        <property type="protein sequence ID" value="AFZ70529"/>
        <property type="gene ID" value="Calag_0787"/>
    </dbReference>
    <dbReference type="GeneID" id="14212047"/>
    <dbReference type="KEGG" id="clg:Calag_0787"/>
    <dbReference type="eggNOG" id="arCOG04309">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059734_1_1_2"/>
    <dbReference type="OMA" id="EIPYQKA"/>
    <dbReference type="OrthoDB" id="71537at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="267" mass="29957" checksum="554A36E90B521CC7" modified="2013-03-06" version="1">MVIGLITDFGNNFYTGIMKGVIKNINNNVSIIDIDNNIPKFSILSGSYVLYTSYEWMPKKAILLAVVDPGVGTERRALILETKNYYFVGPDNGLLYESAINDGIVSMHEIEIEKLNNLLRNKYDLNINISRTFHGRDVFAPSAALLSLNENISLFTKNIDKIVELKILDYIKEDNKIYLKVIYIDDFGNVVLSSKFNNLNIKDSKVVKIIRNGSEIGIKVGEKFADVNEGELLIYENSFGFAEIAMNKGNASKFLGLKIGDEVIISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAT7</accession>
    <name>L0AAT7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type Fe3+-hydroxamate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0471"/>
    <dbReference type="EnsemblBacteria" id="AFZ70237">
        <property type="protein sequence ID" value="AFZ70237"/>
        <property type="gene ID" value="Calag_0471"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0471"/>
    <dbReference type="eggNOG" id="arCOG04233">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_2_8_2"/>
    <dbReference type="OMA" id="KVYFEEW"/>
    <dbReference type="OrthoDB" id="90656at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="38"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="290" mass="33208" checksum="5CD304B78FF4EB01" modified="2013-03-06" version="1">MSIYIRFKIKNIDWCKIVVKLYSEILSKEIEIPDRPEKIVSLAPAITETLYLIGAGDRVVGVSFFCNKPPEVSKKPRVGAYLNVNYNLLEKLNPDLLLVTTGAQRDRINELETKGYKVYPIPLPVNIYGILDNVMITGIIANEQEKARELAFNLTEKILKLKDILKGIRIYYEIDLGGPVSVGSHSYIGDAFKFMGLSHAFEKERVPYVINPDPNYIINYNPDIIVYEQKMNENATVEKYIKNLEKRNIKDIDAIKKKKIVIMEYDSLAHYGPSFFDAAMRLAERIKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAU2</accession>
    <name>L0AAU2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Acylphosphatase</fullName>
            <ecNumber evidence="1 2">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1 2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232436.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0798"/>
    <dbReference type="EnsemblBacteria" id="AFZ70539">
        <property type="protein sequence ID" value="AFZ70539"/>
        <property type="gene ID" value="Calag_0798"/>
    </dbReference>
    <dbReference type="GeneID" id="14212058"/>
    <dbReference type="KEGG" id="clg:Calag_0798"/>
    <dbReference type="eggNOG" id="arCOG01674">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_1_1_2"/>
    <dbReference type="OMA" id="RESHFDI"/>
    <dbReference type="OrthoDB" id="111329at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="87" mass="10008" checksum="79A7C4097DB3E21A" modified="2013-03-06" version="1">MEICLKILVNGHVQGVGFRHFIWSNAKKLNLKGYAKNLPDGRVEVVASGLNDSINKLIDIIKNSYFDIEDIKVEQLYNCSFDDFRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAU4</accession>
    <name>L0AAU4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sucD</name>
        <name evidence="7" type="ordered locus">Calag_0481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232145.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0481"/>
    <dbReference type="EnsemblBacteria" id="AFZ70247">
        <property type="protein sequence ID" value="AFZ70247"/>
        <property type="gene ID" value="Calag_0481"/>
    </dbReference>
    <dbReference type="GeneID" id="14211741"/>
    <dbReference type="KEGG" id="clg:Calag_0481"/>
    <dbReference type="eggNOG" id="arCOG01339">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_2"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="OrthoDB" id="37867at2157"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="293" mass="30936" checksum="16892F85D20F73C5" modified="2013-03-06" version="1">MGILVDKNTRVIVQGITGNEGSFHTKLMLDYGTKVVAGVTPGKGGMKVHGVPVYDTVSEAVKEHPDANTSIIFVPAKFAADAVYESVDAGLKLVVVITEHIPVHDSLEFINYAKSKGVNVIGPNCPGAITPGESKVGIMPAHVFMPGPVGIASRSGTLTYEVSYALSRAGIGQSTVIGIGGDPVIGLTFTEVMEYYEKDKQTKALIIVGEIGGDAEERAAKMVEEKRFTKPVVAFIAGRTAPEGKRMGHAGAIIMLGSGTYKDKVEKLESVGIKVAKTPFELPKLINDALKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAU8</accession>
    <name>L0AAU8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232441.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70544">
        <property type="protein sequence ID" value="AFZ70544"/>
        <property type="gene ID" value="Calag_0803"/>
    </dbReference>
    <dbReference type="GeneID" id="14212063"/>
    <dbReference type="KEGG" id="clg:Calag_0803"/>
    <dbReference type="eggNOG" id="arCOG01804">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_878795_0_0_2"/>
    <dbReference type="OMA" id="AIAIWEP"/>
    <dbReference type="OrthoDB" id="114594at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="316" mass="35422" checksum="534104A043DD659E" modified="2013-03-06" version="1">MEELDEFDFELYNYIKEYMPITLSELARNVKHSKSMIYKRIKKLEYYGLINIKNQGGVSIILINDQKNPVISIGILRASEYPYILNFVKGLRDIFDHVNIVVYDNAFKEAVDLSTGKIQLAMNPAISLLAINRLSKGMVHIIGGGSGGGSGIAMNPSGKEGHSTSMMSSMELCAEINKLETPRIYSNSGDEILNKVVSGHVRYGVLWEPYLSIASRNNIKTISCELDTCCLLGANASLSEKYEKITKIFSKTISTFKMTNLDGYANLIGMPLDLVKQSVKNYTFFEEPDKNYLKKNLSNIRNVVLPYNVIEQSVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAY9</accession>
    <name>L0AAY9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232093.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0427"/>
    <dbReference type="EnsemblBacteria" id="AFZ70195">
        <property type="protein sequence ID" value="AFZ70195"/>
        <property type="gene ID" value="Calag_0427"/>
    </dbReference>
    <dbReference type="GeneID" id="14211687"/>
    <dbReference type="KEGG" id="clg:Calag_0427"/>
    <dbReference type="eggNOG" id="arCOG01736">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081251_3_4_2"/>
    <dbReference type="OMA" id="HITLRFL"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="100"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="42"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="185" mass="20979" checksum="E1F571E14D294218" modified="2013-03-06" version="1">MVRAFIAVDVNDNSIINKINDTIQALSELSLKIKFVETENLHITLRFLGEISEGDVLTIKENVISKLKCEPFNIVLKGLGAFPNNENPRVIWIGISEGFDFLKKLKIQIDDLLIKNGFKLSHEEFVAHLTIGRIKFGKSSALKELLEQYRNFDYGTIKVNSVKLKKSTLTRQGPIYENLVEANCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB09</accession>
    <name>L0AB09_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">6-phospho 3-hexuloisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIS family. PHI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1357"/>
    <dbReference type="EnsemblBacteria" id="AFZ71066">
        <property type="protein sequence ID" value="AFZ71066"/>
        <property type="gene ID" value="Calag_1357"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1357"/>
    <dbReference type="eggNOG" id="arCOG00068">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094236_1_0_2"/>
    <dbReference type="OMA" id="KTIQPMG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05005">
        <property type="entry name" value="SIS_PHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017552">
        <property type="entry name" value="PHI/rmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43443">
        <property type="entry name" value="PTHR43443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03127">
        <property type="entry name" value="RuMP_HxlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="43"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="209" mass="22663" checksum="854ECC2D97869AD6" modified="2013-03-06" version="1">MSSLDNESQNHTAIVAMKEIANFVIKASEIIDTKEVDNFVSLLIDTYNNKAKVLVMGAGRSGLVGKAFAMRLLHMGFSSYVLGETIVPSISKGDLAIAISGSGRTQLIVDAADAAKKVGSKVVALTTFPDSPLGSIADVIVKIPGRSKISKMDDYFARQILGLHEPFAPLGTLFEDTTMIFLDGVVYHLMSRLNISEDQMRNRHANVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB31</accession>
    <name>L0AB31_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1389"/>
    <dbReference type="EnsemblBacteria" id="AFZ71098">
        <property type="protein sequence ID" value="AFZ71098"/>
        <property type="gene ID" value="Calag_1389"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1389"/>
    <dbReference type="eggNOG" id="arCOG03872">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1754594_0_0_2"/>
    <dbReference type="OMA" id="VFIMANS"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="148" mass="16573" checksum="B369BCA3C18A2905" modified="2013-03-06" version="1" precursor="true">MRNMKRKALSNLIGTIILISATLIGGVLVYNYFQKSMTTMENMGQNVFIMANSQIINSNSQIIYIKITNNMQGQIKIIGIYGIYQNGTQENLTLTSNNINPDIINKYINSGETVSFVIYASSNIQSIFLQYNDTQSNVIMSSQPVNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB41</accession>
    <name>L0AB41_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dCTP deaminase</fullName>
            <ecNumber evidence="2">3.5.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Deoxycytidine triphosphate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dcd</name>
        <name evidence="4" type="ordered locus">Calag_1400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the deamination of dCTP to dUTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dCTP + H(+) + H2O = dUTP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="EC" id="3.5.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233005.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1400"/>
    <dbReference type="EnsemblBacteria" id="AFZ71108">
        <property type="protein sequence ID" value="AFZ71108"/>
        <property type="gene ID" value="Calag_1400"/>
    </dbReference>
    <dbReference type="GeneID" id="14212660"/>
    <dbReference type="KEGG" id="clg:Calag_1400"/>
    <dbReference type="eggNOG" id="arCOG04048">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087476_3_0_2"/>
    <dbReference type="OMA" id="FENHRYP"/>
    <dbReference type="OrthoDB" id="91282at2157"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="3">
        <location>
            <begin position="52"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="99"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ71108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="176" mass="19975" checksum="D1FDEC3FE2FFBEBB" modified="2013-03-06" version="1">MILSDRDIKILLKSGELIINPLSDDTVRENGLDLKLGNEYCAFKKTDTVLDPNNPKDPKEFYECNSSNSFIIEPHRHYLLHTLEYVKLPSYLAGLVNLRSTWARTGIYIPSTVTDAGFEGQLTIEVIGSEFPVKLYSGDRFLHLILVKMETPSEKPYDGSYKGQTGVKLPKFFNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB52</accession>
    <name>L0AB52_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family 31 glycosyl hydrolase, alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232541.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0906"/>
    <dbReference type="EnsemblBacteria" id="AFZ70644">
        <property type="protein sequence ID" value="AFZ70644"/>
        <property type="gene ID" value="Calag_0906"/>
    </dbReference>
    <dbReference type="GeneID" id="14212166"/>
    <dbReference type="KEGG" id="clg:Calag_0906"/>
    <dbReference type="eggNOG" id="arCOG03663">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_7_2_2"/>
    <dbReference type="OMA" id="IEPWGPN"/>
    <dbReference type="OrthoDB" id="13106at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="137"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="706" mass="81823" checksum="7FB53F07FDCAC5AB" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABB9</accession>
    <name>L0ABB9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232611.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0991"/>
    <dbReference type="EnsemblBacteria" id="AFZ70714">
        <property type="protein sequence ID" value="AFZ70714"/>
        <property type="gene ID" value="Calag_0991"/>
    </dbReference>
    <dbReference type="GeneID" id="14212251"/>
    <dbReference type="KEGG" id="clg:Calag_0991"/>
    <dbReference type="HOGENOM" id="CLU_1840463_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="139" mass="16388" checksum="1135DC14D809DCB8" modified="2013-03-06" version="1">MGEKKKLKDLRGSQSRIFRLRSFYLEGFIHAIFYRIQIPVSIIYGIILLSWLFYPGLALTVKAFTALVWILFIPQLFESVKGLALSMSRGMVFGKLNNEYAHLYRLRYKKNLVHLRLAPYLVLAIWIIGFIAMIIWWYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABD2</accession>
    <name>L0ABD2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Threonine synthase</fullName>
            <ecNumber evidence="5 9">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Calag_1007</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5 9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1007"/>
    <dbReference type="EnsemblBacteria" id="AFZ70729">
        <property type="protein sequence ID" value="AFZ70729"/>
        <property type="gene ID" value="Calag_1007"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1007"/>
    <dbReference type="eggNOG" id="arCOG01434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_0_0_2"/>
    <dbReference type="OMA" id="MWGFQAS"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="67"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="10">
        <location>
            <begin position="224"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)" evidence="12">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ70729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="394" mass="43528" checksum="7F50FF1FDEFDA86E" modified="2013-03-06" version="1">MIDKHGFMKCISCNSTFDIDQNLIVCPKCGGLLEIINEKEIDIKRLKGKGVWRYKDFIPGNYKKIVSLNEGNTPLIKSRKFENLYFKFEGLNPTGSFKDRGMTIAISSAATLGYKIVVAASTGNTAASASAYSARAGLKTILFLPKGKVAKGKLFQSILHGAHIVEINGNFDEALDKVKKLFNKNKDVYPVNSFNPWRLEGQKTIAFEIFEEIGNPDFVIVPTGNAGNIYAIWKGFKELEKSGLIEKIPKMIAVQSSGSSPIADYIIGKKKKIEFVENPETIATAIRIGKPVNYMKAIKAIEDSNGYAIKVDDKEIIEGQKELAREEGIGVEPASASTIAAYHKLLNNGYLNKYDKGVLILTGHALKDPNILFEEDSYSISSNDIEVFINKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABD7</accession>
    <name>L0ABD7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type dipeptide transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232263.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0608"/>
    <dbReference type="EnsemblBacteria" id="AFZ70365">
        <property type="protein sequence ID" value="AFZ70365"/>
        <property type="gene ID" value="Calag_0608"/>
    </dbReference>
    <dbReference type="GeneID" id="14211868"/>
    <dbReference type="KEGG" id="clg:Calag_0608"/>
    <dbReference type="eggNOG" id="arCOG01533">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319962_0_0_2"/>
    <dbReference type="OMA" id="ESENNLM"/>
    <dbReference type="OrthoDB" id="6658at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="171"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="894" mass="101006" checksum="29F56B0181F4F84D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABE9</accession>
    <name>L0ABE9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1523"/>
    <dbReference type="EnsemblBacteria" id="AFZ71223">
        <property type="protein sequence ID" value="AFZ71223"/>
        <property type="gene ID" value="Calag_1523"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1523"/>
    <dbReference type="eggNOG" id="arCOG03692">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1243094_0_0_2"/>
    <dbReference type="OMA" id="KIGVWRK"/>
    <dbReference type="OrthoDB" id="92515at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024533">
        <property type="entry name" value="DUF3834"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12916">
        <property type="entry name" value="DUF3834"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="220" mass="24138" checksum="5A0EB2F8E5225FA6" modified="2013-03-06" version="1">MINMEKIMVAPGPVSYPLILSEDKSNISLIFDKEGIADAVADSITSLIKRGLNVDFITVKELLTIHPDLRGPKIGVFRKGSAGEILLKALMDKQNIKGEIVYSDNMQDLLHMLNLGEINSAVISIAMVKPKETLESIVGAPGACGISINKNESIKTVKEAYELGISIAKKNPEESADKIVSRLPITVSKDFVYKIITRAEYFFKPAGNINSFVELVKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABG1</accession>
    <name>L0ABG1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sterol carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232656.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1037"/>
    <dbReference type="EnsemblBacteria" id="AFZ70759">
        <property type="protein sequence ID" value="AFZ70759"/>
        <property type="gene ID" value="Calag_1037"/>
    </dbReference>
    <dbReference type="GeneID" id="14212297"/>
    <dbReference type="KEGG" id="clg:Calag_1037"/>
    <dbReference type="eggNOG" id="arCOG01843">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105945_1_4_2"/>
    <dbReference type="OMA" id="NIMDAAT"/>
    <dbReference type="OrthoDB" id="123357at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="113" mass="12685" checksum="1027CC27B21F2C6A" modified="2013-03-06" version="1">MSLDEMRVSLERIYEKAKDKVPEIKSWNKAYQFVVEGEGEFYVEISNGKINIASGRHPNPIATLTAKPDVMKKIITGELDSMKAFMTRQLKITGNVLDTVNLKRVIDAGLGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABH4</accession>
    <name>L0ABH4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="7">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisS</name>
        <name evidence="9" type="ordered locus">Calag_1550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="7"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233145.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1550"/>
    <dbReference type="EnsemblBacteria" id="AFZ71248">
        <property type="protein sequence ID" value="AFZ71248"/>
        <property type="gene ID" value="Calag_1550"/>
    </dbReference>
    <dbReference type="GeneID" id="14212812"/>
    <dbReference type="KEGG" id="clg:Calag_1550"/>
    <dbReference type="eggNOG" id="arCOG00404">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_3_0_2"/>
    <dbReference type="OMA" id="CDFDFIG"/>
    <dbReference type="OrthoDB" id="47919at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="21"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ71248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="434" mass="50351" checksum="A6D209260F7C7E95" modified="2013-03-06" version="1">MSKEYRPPRGFRDFPPEVMILRKELISKIENVFKRYGFDPLDTPAVEYWETLAGKYGEEAENRLIWKFKDPWSDREYALRYDLTVPLARFVSSHPEIQMPFKRYQISPVWRHEEPQKGRYREFYQCDADIVGSPYPEADAEMINLIVDSIKSLGFESGFSLRLNDRRLLSGIFEQELNIKSPLAVYRIIDKLDKIGIDNVKKELLEQINNEEIVNKIIEVISLSGKPEEILENLYSKYGRNKLVNDAYNHLKEMLDLINNKNDIIIDLSLVRGLDYYTGPIYEVVLKEPKIGSVSGGGRYDNLAGIFSGKQIPATGGSIGIERIIDAGLELGLFNLNKKTFTEIQVIFMSQDLFKHAWHIANILRSEGYNVRIDLNRSKEELQRRKANKLDIKLLIFIGKKEIETNTVTIYNTKTNERANLNINELKDKIKQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABJ0</accession>
    <name>L0ABJ0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATPase involved in replication control, Cdc46/Mcm family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232313.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0664"/>
    <dbReference type="EnsemblBacteria" id="AFZ70415">
        <property type="protein sequence ID" value="AFZ70415"/>
        <property type="gene ID" value="Calag_0664"/>
    </dbReference>
    <dbReference type="GeneID" id="14211924"/>
    <dbReference type="KEGG" id="clg:Calag_0664"/>
    <dbReference type="eggNOG" id="arCOG00439">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_6_0_2"/>
    <dbReference type="OMA" id="NAYTCDR"/>
    <dbReference type="OrthoDB" id="3067at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="PTHR11630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="4">
        <location>
            <begin position="293"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="697" mass="78332" checksum="48ECE7FDB893691B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-02-10" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABK0</accession>
    <name>L0ABK0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpB</name>
        <name evidence="14" type="ordered locus">Calag_0676</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0676"/>
    <dbReference type="EnsemblBacteria" id="AFZ70425">
        <property type="protein sequence ID" value="AFZ70425"/>
        <property type="gene ID" value="Calag_0676"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0676"/>
    <dbReference type="eggNOG" id="arCOG01432">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042858_1_0_2"/>
    <dbReference type="OMA" id="RYHAVAP"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006316">
        <property type="entry name" value="Trp_synth_b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF6">
        <property type="entry name" value="PTHR48077:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500824">
        <property type="entry name" value="TrpB_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01415">
        <property type="entry name" value="trpB_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="70"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ70425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="428" mass="48042" checksum="83E0E7D5177718BC" modified="2013-03-06" version="1">MRFDLPQDRIPEYWYNILPDLPEKLPEPIDATGKSFETLKTVLPSNVLNYEFSQERLIRIPDEVLERYLQVGRPTPIIRARRLEEKFNNMIKIYMKMESYTYTGSHKINSAIAHVYYAKMDNAKFVSTETGAGQWGSAVSLAAALFKIKAYVFMVRTSYYAKPYRKYLMMMYGANVNPSPSNLTDFGRQLLTKDPNHPGSLGIAISEAVKYAMDNGGKYVVGSVVNSDIMFKTIAGMEAKVQMEEIGEDPDYIIGVVGGGSNYAALAYPFLGDELRKGEIRRKYIASGSSEVPKMTKGVYKYDFPDTAMILPQLKMYSIGSDFVPPPIYAGGLRYHAVAPTLSLLMNKGIVEARDYTQEETFKWAKLFAETEGYIPAPETAHALPILEEIAEKAKKDKEVKTVLMSFSGHGLLDLGNYADVLGFERIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABM8</accession>
    <name>L0ABM8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_1107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232726.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1107"/>
    <dbReference type="EnsemblBacteria" id="AFZ70829">
        <property type="protein sequence ID" value="AFZ70829"/>
        <property type="gene ID" value="Calag_1107"/>
    </dbReference>
    <dbReference type="GeneID" id="14212367"/>
    <dbReference type="KEGG" id="clg:Calag_1107"/>
    <dbReference type="eggNOG" id="arCOG00332">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005304_1_0_2"/>
    <dbReference type="OMA" id="SGCPYCL"/>
    <dbReference type="OrthoDB" id="44343at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="279"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="688" mass="78439" checksum="27C0C0BEF3D6C576" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABP0</accession>
    <name>L0ABP0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0248 protein Calag_0801</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0248 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232439.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0801"/>
    <dbReference type="EnsemblBacteria" id="AFZ70542">
        <property type="protein sequence ID" value="AFZ70542"/>
        <property type="gene ID" value="Calag_0801"/>
    </dbReference>
    <dbReference type="GeneID" id="14212061"/>
    <dbReference type="KEGG" id="clg:Calag_0801"/>
    <dbReference type="eggNOG" id="arCOG01302">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2490238_0_0_2"/>
    <dbReference type="OMA" id="PIHRIVE"/>
    <dbReference type="OrthoDB" id="121890at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01245">
        <property type="entry name" value="UPF0248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007547">
        <property type="entry name" value="UPF0248"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MJ1316" evidence="2">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="86" mass="10000" checksum="4861D046BD8D2A69" modified="2013-03-06" version="1">MAKKRSKIKDIISKAIYSDKKETYTITYIDRTNDYGIRLLQITTDEVFAVSNWAITLNDNETVIPIHRIVEIKDNDGKILWKKGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABW7</accession>
    <name>L0ABW7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine monophosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232504.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0867"/>
    <dbReference type="EnsemblBacteria" id="AFZ70607">
        <property type="protein sequence ID" value="AFZ70607"/>
        <property type="gene ID" value="Calag_0867"/>
    </dbReference>
    <dbReference type="GeneID" id="14212127"/>
    <dbReference type="KEGG" id="clg:Calag_0867"/>
    <dbReference type="eggNOG" id="arCOG00638">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_971823_0_0_2"/>
    <dbReference type="OMA" id="DFGWRNV"/>
    <dbReference type="OrthoDB" id="104636at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="1">
        <location>
            <begin position="40"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="286" mass="32385" checksum="CBF38E40F8734D7F" modified="2013-03-06" version="1">MKNSKNEWCKDYDACPLEDFLINIDGYASSRSKLPWMTYEDWSFKAALASASDVIVSGGKPIALSYSVGATDENVLKSVSLGIGKASEYLKSIVLKGDSNKSINDSWIDVVFIGKMENKKYVKRSGAKKGDYLIQIGYLGYGSLAQKLLENKININEIDKNILNKTITPDFQINAYIPIYKYATSSSDNSDGWMSTLYNISESSRVKILLDSIEIDPLLNNYIHEEEALYSWEDYNFAATVSEENLDYFLEECSNLNIRCFVVGKIDEGYGVYYNNKKVNNFGWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABX5</accession>
    <name>L0ABX5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetate--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0809</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0809"/>
    <dbReference type="EnsemblBacteria" id="AFZ70550">
        <property type="protein sequence ID" value="AFZ70550"/>
        <property type="gene ID" value="Calag_0809"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0809"/>
    <dbReference type="eggNOG" id="arCOG01529">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_2"/>
    <dbReference type="OMA" id="DHWWHDL"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="6">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="4">
        <location>
            <begin position="78"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="5">
        <location>
            <begin position="530"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="650" mass="73752" checksum="6BE03878E0B8D659" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABY0</accession>
    <name>L0ABY0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1220"/>
    <dbReference type="EnsemblBacteria" id="AFZ70939">
        <property type="protein sequence ID" value="AFZ70939"/>
        <property type="gene ID" value="Calag_1220"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1220"/>
    <dbReference type="eggNOG" id="arCOG00042">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_938790_0_0_2"/>
    <dbReference type="OMA" id="SHIKANC"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="282" mass="32253" checksum="BA4E76C8AD07A615" modified="2013-03-06" version="1">MDKICSICKKRQAIYYRAYSGEYICAKCLNNVMEKNVKKEINKTKSLSIDSKIVIPITYFSPSSSIALSNLIYRIEKRYKSRIAIVIPKDYNIEEIKNFLENKSDLFIAEINIKPPERLSLQECIRFERVWSMRAAKILGYEFVFLPVSRTDISLIVIDSLINGKANLLSESLEFIEYNGIKFLYPFSGIEGETLVSYEFLSGINVKPLCLTNIKSKNVFYSIAGNRPELDFGSERLLDKLGNFLDKLGKCKICAGFSDKEICDTCNKLNLKELDVKLSFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABY5</accession>
    <name>L0ABY5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AcnX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232457.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0819"/>
    <dbReference type="EnsemblBacteria" id="AFZ70560">
        <property type="protein sequence ID" value="AFZ70560"/>
        <property type="gene ID" value="Calag_0819"/>
    </dbReference>
    <dbReference type="GeneID" id="14212079"/>
    <dbReference type="KEGG" id="clg:Calag_0819"/>
    <dbReference type="eggNOG" id="arCOG04278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018825_1_0_2"/>
    <dbReference type="OMA" id="CTCTPYL"/>
    <dbReference type="OrthoDB" id="31127at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007506">
        <property type="entry name" value="AcnX_catalytic_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04412">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcnX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="400" mass="44683" checksum="6A8750A94BAB2E8F" modified="2013-03-06" version="1">MYLTKEEEKMLNGDYGWAVSKALKVIVSIGESLNAEKLINISHAHISGVSYGNIGDPGRKLIKEFADSGVKFSVKTTVNPIGYDTIDYDAIPLTKIDRNYLKGQEDILMSLKKMGANLSLSCTPYYLPEVIDIKEGSSVAWGESNAVVYGNSVLGIKTNREGGPISLMAAITGKTYYYGLHIDENRIPSIRYIIRRPDDYELNEVRIGIIGEIISKAHNDERPPYLDEYISNETIIKELSASLGAAGNIAMIVIKGVTKQKIDENKLKETFTIDYKDIKTREDELMPSKTPDIIYFGCPHANKDEIEKIANQLKEFEKINSQIIITTSREQISKVSKETLSILKEKNVKLIGDTCLIVSPFGYRGLNIATNSYKAYFYLSKKGINVSLISINNLKEVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC30</accession>
    <name>L0AC30_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Peptide chain release factor subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Translation termination factor aRF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prf1</name>
        <name evidence="11" type="ordered locus">Calag_1273</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232886.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1273"/>
    <dbReference type="EnsemblBacteria" id="AFZ70989">
        <property type="protein sequence ID" value="AFZ70989"/>
        <property type="gene ID" value="Calag_1273"/>
    </dbReference>
    <dbReference type="GeneID" id="14212533"/>
    <dbReference type="KEGG" id="clg:Calag_1273"/>
    <dbReference type="eggNOG" id="arCOG01742">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035759_3_0_2"/>
    <dbReference type="OMA" id="GQEMEVV"/>
    <dbReference type="OrthoDB" id="32191at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00424">
        <property type="entry name" value="Rel_fact_arch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020918">
        <property type="entry name" value="Peptide_chain-rel_aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PTHR10113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="SSF55481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03676">
        <property type="entry name" value="aRF1/eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="10">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="368" mass="41801" checksum="4EC3398B63B4D355" modified="2013-03-06" version="1">MSNLEEKLLINKKQLAQVLKELKEWSAPATVLLSLYVPPGRPIGDVLQLLRDELSISDNIKLKRTRQAVKRAVSAAMDRVSMLQKIPQNGLVAFCGENMDTGEFICDMFSPPEKVPVFYYRTDKKFVLEILEEMIQSEDVVGIVIVERDQATIGILKGSRLEVLDEVEDYIPGKHMMGGQSQRRIDRIIEQMVDEFLKRLGERVNNYFLPYLEMGKLKAIIIAGPGYAKEDFVKSGYLDYRLQQLVNKELIDVAYQGEQGLREVVMKAQDVVQFAMYREASDALETFKGHLARNTGLVVYGEDDVKRALEMGMVSILLLHEDVNIERWKEEAEKSGAKVIVIPNSLPESDWFYKTFGGVAGILRYKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC46</accession>
    <name>L0AC46_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM additional 4Fe4S-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232599.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0979"/>
    <dbReference type="EnsemblBacteria" id="AFZ70702">
        <property type="protein sequence ID" value="AFZ70702"/>
        <property type="gene ID" value="Calag_0979"/>
    </dbReference>
    <dbReference type="GeneID" id="14212239"/>
    <dbReference type="KEGG" id="clg:Calag_0979"/>
    <dbReference type="eggNOG" id="arCOG00940">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_1_2"/>
    <dbReference type="OMA" id="FGCFAGR"/>
    <dbReference type="OrthoDB" id="18533at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="31"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="359" mass="40924" checksum="27AF8B67CD0BB2BB" modified="2013-03-06" version="1">MYLTFDEQAFLTDCPATPLSHLENDGKYLMSEGPYQVTIYITRECNLNCTHCYISAGSPLNDELNKDEWKLVINKLNDIGTNVLYILGGEPLLKHGIFDIISYSTSLGLYTSLSSNGTVITKGVSKKLKESNINEIQISIDGPNEEINSLIRGKNSFKLAIEGVKNLINENIPTSLSYVITEKNKDYIEDMIKIAEELNVKSINFSPVQQFGRAKINNVLLKRESAIQVYNKLRLLNKKYKIKITTNGFRFFIDNLFDVYLSLKNKINNYYSCPAGRSRFIIDANGDIYGCELLINPLFKEGNALKDDLREIWKKGFTRFRNKWYMEKEECKSCSINSLCQGGCFARAFNSKKDINCPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC61</accession>
    <name>L0AC61_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232614.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0994"/>
    <dbReference type="EnsemblBacteria" id="AFZ70717">
        <property type="protein sequence ID" value="AFZ70717"/>
        <property type="gene ID" value="Calag_0994"/>
    </dbReference>
    <dbReference type="GeneID" id="14212254"/>
    <dbReference type="KEGG" id="clg:Calag_0994"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="NIERAFT"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="295" mass="32831" checksum="89238F71708D2AC9" modified="2013-03-06" version="1">MDDLIIEDVTKKYGNFTVLNNVSLKVRKGEIMALVGPNGAGKSTLIKTSLGLLRRDSGKVLLFNKDPFYESSARERVGVIFERPSLPMSMPIEEFLSHVTKIYNKNSEIIKEAIDLVGLSNYENKPFSQLSAGQRQRAAIAHALISDPDMIIADEPTSNLDPLERNKILELFLKINKQKGLTIMISSHVLPEVLRVSTSIAIMKSGKVIKTGTPDDIIKNISIARIRCKDVRIIKENLEKNGYSLSIEGGNIYVKTENQEGISKLLNLLSDQIKNGQQIYGIELIEPVIEEILEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC92</accession>
    <name>L0AC92_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70655">
        <property type="protein sequence ID" value="AFZ70655"/>
        <property type="gene ID" value="Calag_0924"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0924"/>
    <dbReference type="HOGENOM" id="CLU_3302539_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="39" mass="4631" checksum="1AAF087971570C7D" modified="2013-03-06" version="1">MFGYELNLDTSSIIEDRKKSCKDFKEPIIMIVNSFKINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC93</accession>
    <name>L0AC93_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232649.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1030"/>
    <dbReference type="EnsemblBacteria" id="AFZ70752">
        <property type="protein sequence ID" value="AFZ70752"/>
        <property type="gene ID" value="Calag_1030"/>
    </dbReference>
    <dbReference type="GeneID" id="14212290"/>
    <dbReference type="KEGG" id="clg:Calag_1030"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_2"/>
    <dbReference type="OMA" id="KHMVDAG"/>
    <dbReference type="OrthoDB" id="62124at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="249" mass="27352" checksum="85AE73B44D32A866" modified="2013-03-06" version="1">MSNVVIITGGDRGIGKAIAKRFAKEKYFVIITYNANKEEAEKTLNELKKLGAEKAYSFKLDVSNEGEVKAFSEEVKKITDHVNTLVNNAGIISYTPFEQLTLEEWNKIISVDLTGVFLVTRYLLDLLKKADWASIVNISSIAGQTGSVYGGIPYVAAKAGVIGLTKRLSNELAKYGIRVNAVAPSFVETDLVAEFLKDENKKKSIIELHPLKILLKPEDIAEAVYFFSDPTLSRGVTGQVLGINAGRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACA0</accession>
    <name>L0ACA0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="6" type="ordered locus">Calag_1345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232951.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1345"/>
    <dbReference type="EnsemblBacteria" id="AFZ71054">
        <property type="protein sequence ID" value="AFZ71054"/>
        <property type="gene ID" value="Calag_1345"/>
    </dbReference>
    <dbReference type="GeneID" id="14212605"/>
    <dbReference type="KEGG" id="clg:Calag_1345"/>
    <dbReference type="eggNOG" id="arCOG01919">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031942_3_2_2"/>
    <dbReference type="OMA" id="HFWKSIF"/>
    <dbReference type="OrthoDB" id="93751at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="264" mass="30324" checksum="487B3CCC852D0E74" modified="2013-03-06" version="1">MQSSNSILNEYYKYFNELLRRLLIPAIFFIVILILIMFFKFNKIEIHKFYMYYPFPSLTNSTSVMILKKIKDFMLPKNMVLISVNAFDPIIGSLYTSSLISAIVTSPLWIYEIYAFIFPALTQKERKAINMFIIPSIILFIFGALFSYFIILPALFRFMYYLDLGLGVLPSLSIRAFISTVLSFVLLVGISFEYPIVIMALTYVGFVDYKTLLKYWRYAIALSFIIALIISPGATGGIIEITIGLTLSGLYFLGVLISKYLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACA5</accession>
    <name>L0ACA5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome b subunit of the bc complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Calag_1350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232956.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1350"/>
    <dbReference type="EnsemblBacteria" id="AFZ71059">
        <property type="protein sequence ID" value="AFZ71059"/>
        <property type="gene ID" value="Calag_1350"/>
    </dbReference>
    <dbReference type="GeneID" id="14212610"/>
    <dbReference type="KEGG" id="clg:Calag_1350"/>
    <dbReference type="eggNOG" id="arCOG01721">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038033_0_0_2"/>
    <dbReference type="OMA" id="WNYGPYD"/>
    <dbReference type="OrthoDB" id="14275at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00032">
        <property type="entry name" value="Cytochrom_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="SSF81648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="11">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_CTER" evidence="12">
        <location>
            <begin position="281"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ71059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="455" mass="51435" checksum="2799265F7870E147" modified="2013-03-06" version="1">MSKSKEGFWNKFFERFGIKNIDDILRPIPEFSFRPDYWLGALLVVGFVMQGITGFLLLLNYIPTTTDAYTSTSNIVNKIPYGSLLLNFHLYNAYAIIFLAFVHMFRNFWQGTYKRPREGMWIVGVILGLITLGFGFTGYLLPWTVLSKSATDVGIGLLSYLPSWMTSWLHTLLIGNGTDADELQRFFDIHVILLPILLVVFLGLKLFMFEAHGMSEPPKKGVVENIKNERKGISWWPRGVEYLLAISLFYIGAIVIIASVFPVPLGPMYTPQAASQYTPEPDWYFLWMYQIIKQSIFGGANIVYGIYLIGLLFIILLIVPFIDRSPFRHVSDRPVIITLGMMVVSTLIFFTIWAYLTPGLTIPFTQTLEFLIPMYVIEAIGAYLGTRSNKTKTSKNIIKTKPNTVAAIIALLLTIVGGALSINLIVSKDVAWGIVLLLGFTFMIVEIMRRSHSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACC6</accession>
    <name>L0ACC6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1065"/>
    <dbReference type="EnsemblBacteria" id="AFZ70787">
        <property type="protein sequence ID" value="AFZ70787"/>
        <property type="gene ID" value="Calag_1065"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1065"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_4_2"/>
    <dbReference type="OMA" id="TTIETHW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="132"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="327" mass="36984" checksum="9EEB9B56DE9D00A1" modified="2013-03-06" version="1">MVGSRGFGRVHLYALNKLKNEGYDLKLYVFSSDKSEAEKLGKEFMASGIFTSYDEILSSDVDIVDLIVSHDSHLDMSVKAMERKKHVILEKPIARTVEEATKIIEKAKISKVKFMVAENYYFDSSIRKAVELTNNELGKIYSIIVRYSTYNQPRTWRKNKQSMGGGALIDGGIHFVDAMLNLGGSYDKICSISYKTYVDMEGEDTTVAIINFKNGAKGTLIFSWGMNNSPLVPAFEVYGEKGTIYEDPYTRKVEISGKTKYVRRFGDIIYNNNRVEIPDSDSIKDELKGFIDSIINETQVPMPPEIALRDLRAVLDIYDSNCFKQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACE7</accession>
    <name>L0ACE7_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA/RNA-binding protein Alba</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">albA</name>
        <name evidence="9" type="ordered locus">Calag_0997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232617.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0997"/>
    <dbReference type="EnsemblBacteria" id="AFZ70720">
        <property type="protein sequence ID" value="AFZ70720"/>
        <property type="gene ID" value="Calag_0997"/>
    </dbReference>
    <dbReference type="GeneID" id="14212257"/>
    <dbReference type="KEGG" id="clg:Calag_0997"/>
    <dbReference type="eggNOG" id="arCOG01753">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110989_1_0_2"/>
    <dbReference type="OMA" id="ARGRNIC"/>
    <dbReference type="OrthoDB" id="111461at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01122">
        <property type="entry name" value="AlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013795">
        <property type="entry name" value="DNA/RNA-bd_Alba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028732">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Alba" evidence="8">
        <location>
            <begin position="9"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="7">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="100" mass="11476" checksum="AD4D6BFAFAB31097" modified="2013-03-06" version="1" precursor="true">MSENQQKLIYIGRKPLMNYALVAIQMFNYENAEEIKIRARGSNICKAVDLVEYLKNMYYKDLTLKDLNIFSEEISDEKGSKKTLPSIEITINKGKNAPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACH0</accession>
    <name>L0ACH0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroorotase-like cyclic amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232647.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1028"/>
    <dbReference type="EnsemblBacteria" id="AFZ70750">
        <property type="protein sequence ID" value="AFZ70750"/>
        <property type="gene ID" value="Calag_1028"/>
    </dbReference>
    <dbReference type="GeneID" id="14212288"/>
    <dbReference type="KEGG" id="clg:Calag_1028"/>
    <dbReference type="eggNOG" id="arCOG00689">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_1_2"/>
    <dbReference type="OMA" id="QHAQEPR"/>
    <dbReference type="OrthoDB" id="43469at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="48"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="407" mass="46638" checksum="62A540BAAC1F4CDE" modified="2013-03-06" version="1">MISICGYLYDYRGFLGNGCVNINDQGTIDSISKLPKMEKVYKFEKYIIGPGLVDLHVHLRGLDLSYKEDEETGTKSALKSGITLVVDMPNTKPRLDNYSAIKSKLNSLKEKSYTDYGVYSAIPKNTKDMEEVLKLPIAGFKIYPEDIGNRKDMIKEVLKLNRFTIVHPELPEAEKIHDEENLLRGILRGCHLEGAAVDVIHKFNENAKVHITHASCPSTVLEAKKFGYTVDTTPHHLFYNSKNQGCYYRVNPPLREEYIRENLMKLFIDGNIDALCSDHAPHSKKEKENFKTCPSGIPWLGSWPWLIFRLVKYDLIKISNFFYYISYSPSKILGLNNYGSLEKGKRGNIITIDKDKVWRFIETYSKAPYYNHFMEENYGFVTNAFIGGELVLDNDNIIKGKNIINPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACT2</accession>
    <name>L0ACT2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_1143</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232762.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1143"/>
    <dbReference type="EnsemblBacteria" id="AFZ70865">
        <property type="protein sequence ID" value="AFZ70865"/>
        <property type="gene ID" value="Calag_1143"/>
    </dbReference>
    <dbReference type="GeneID" id="14212403"/>
    <dbReference type="KEGG" id="clg:Calag_1143"/>
    <dbReference type="eggNOG" id="arCOG00707">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_2"/>
    <dbReference type="OMA" id="AHHKDAW"/>
    <dbReference type="OrthoDB" id="9593at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="10">
        <location>
            <begin position="4"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="610" mass="68305" checksum="112712ACDB2A5925" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACY3</accession>
    <name>L0ACY3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S17e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps17e</name>
        <name evidence="5" type="ordered locus">Calag_1288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232899.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1288"/>
    <dbReference type="EnsemblBacteria" id="AFZ71002">
        <property type="protein sequence ID" value="AFZ71002"/>
        <property type="gene ID" value="Calag_1288"/>
    </dbReference>
    <dbReference type="GeneID" id="14212548"/>
    <dbReference type="KEGG" id="clg:Calag_1288"/>
    <dbReference type="eggNOG" id="arCOG01885">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176720_2_0_2"/>
    <dbReference type="OMA" id="TRDFEHN"/>
    <dbReference type="OrthoDB" id="128227at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_S17e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="RPS17e-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="PTHR10732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="SSF116820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="78" mass="9065" checksum="2F54687971FBD501" modified="2013-03-06" version="1">MGKVRTLMIKRLARELLKDHPDLFTEDFNMNKQVVGKITNYKSKRLRNQVAGYVTSLVKLSKKKQKIMEENIGSAQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACZ1</accession>
    <name>L0ACZ1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molecular chaperone (Small heat shock protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232904.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1293"/>
    <dbReference type="EnsemblBacteria" id="AFZ71007">
        <property type="protein sequence ID" value="AFZ71007"/>
        <property type="gene ID" value="Calag_1293"/>
    </dbReference>
    <dbReference type="GeneID" id="14212553"/>
    <dbReference type="KEGG" id="clg:Calag_1293"/>
    <dbReference type="eggNOG" id="arCOG01833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117605_1_0_2"/>
    <dbReference type="OMA" id="YYGFEIT"/>
    <dbReference type="OrthoDB" id="100198at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="78"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="83"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="174" mass="20114" checksum="45B0C0F286ECA8A9" modified="2013-03-06" version="1">MSNNPKKRKSIFDIFDDIMREMEEEMREFEESFEDLMKQQNVKGENPYYYGVRIFVGPDGVPKVEEFGNIKKGKYGKPIISDEIEPIVDVIDHNDEIWIVADLPGVAKENIKVNATEDKIYIKANSDIRKYSKEIDLPSKIDPDSVKASYKNGVLEIKVKKKNEEPKGKEIKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD05</accession>
    <name>L0AD05_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232832.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1216"/>
    <dbReference type="EnsemblBacteria" id="AFZ70935">
        <property type="protein sequence ID" value="AFZ70935"/>
        <property type="gene ID" value="Calag_1216"/>
    </dbReference>
    <dbReference type="GeneID" id="14212476"/>
    <dbReference type="KEGG" id="clg:Calag_1216"/>
    <dbReference type="eggNOG" id="arCOG01016">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2067657_0_0_2"/>
    <dbReference type="OMA" id="FCANKKS"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="119" mass="14017" checksum="83D01DD4E8CCEA24" modified="2013-03-06" version="1">MERRIEERRYISYYEAKYFMERRIEDSPQINSLQEKSWDYLKTFGDGDSEKASKAIKDLMEMGLKDTTAIMLLNICSDNYSFILSIISSLPEEESTKIDEEKSKKIFEIINNFCANKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD30</accession>
    <name>L0AD30_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232944.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1338"/>
    <dbReference type="EnsemblBacteria" id="AFZ71047">
        <property type="protein sequence ID" value="AFZ71047"/>
        <property type="gene ID" value="Calag_1338"/>
    </dbReference>
    <dbReference type="GeneID" id="14212598"/>
    <dbReference type="KEGG" id="clg:Calag_1338"/>
    <dbReference type="eggNOG" id="arCOG06043">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2645681_0_0_2"/>
    <dbReference type="OMA" id="QDNEASA"/>
    <dbReference type="OrthoDB" id="127436at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="76" mass="8897" checksum="3CB2DCA42B246BB7" modified="2013-03-06" version="1">MSKESIEKIVFPEIHAVTYKPKSECEFFSVIEKEGSYYAKCKFLDSMITKSKISKCEKDYKTCPYRKLGLKTLENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADN2</accession>
    <name>L0ADN2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved protein of DIM6/NTAB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233139.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1544"/>
    <dbReference type="EnsemblBacteria" id="AFZ71242">
        <property type="protein sequence ID" value="AFZ71242"/>
        <property type="gene ID" value="Calag_1544"/>
    </dbReference>
    <dbReference type="GeneID" id="14212806"/>
    <dbReference type="KEGG" id="clg:Calag_1544"/>
    <dbReference type="eggNOG" id="arCOG02017">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_1_2_2"/>
    <dbReference type="OMA" id="WFDRGYH"/>
    <dbReference type="OrthoDB" id="76604at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="25"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="173" mass="19934" checksum="2E08493883D40151" modified="2013-03-06" version="1">MFIKYLLQNNVGESLNEQDLLKLFMRQSAQQVYVVTAKYNNEYSAITVSSATSMSLDPPLMMIAIDKKSHNHDVLTKSDYFIITLLYHKDEEISKIMADKIDAKEKLQKTGYKETDYGPILNIERPYLILSRYKVYDAGDHSIILGKILDGKISNIDCPLVYYNRNYTTVKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADR0</accession>
    <name>L0ADR0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233169.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1574"/>
    <dbReference type="EnsemblBacteria" id="AFZ71272">
        <property type="protein sequence ID" value="AFZ71272"/>
        <property type="gene ID" value="Calag_1574"/>
    </dbReference>
    <dbReference type="GeneID" id="14212836"/>
    <dbReference type="KEGG" id="clg:Calag_1574"/>
    <dbReference type="eggNOG" id="arCOG05401">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130233_0_0_2"/>
    <dbReference type="OMA" id="EAEMITY"/>
    <dbReference type="OrthoDB" id="91906at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="176" mass="19667" checksum="278BDA217E75EA92" modified="2013-03-06" version="1">MSEDNQNNEEKKQEKTYTIRGLNEDLYESFTKAAKEMGTTVGELMNQAMSQFLVTLEAGKDVGKKISEKASKASSTLVKGPFDAFKQLLSYIGEFDIVSNITELTVTKQDLENSEKPIVFSNIKKLVFSPDIDINTFNTKVRSIKVVDEVVVPSTLPLIPVAKKCQLVKKITQLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADV2</accession>
    <name>L0ADV2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233122.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1526"/>
    <dbReference type="EnsemblBacteria" id="AFZ71225">
        <property type="protein sequence ID" value="AFZ71225"/>
        <property type="gene ID" value="Calag_1526"/>
    </dbReference>
    <dbReference type="GeneID" id="14212787"/>
    <dbReference type="KEGG" id="clg:Calag_1526"/>
    <dbReference type="eggNOG" id="arCOG01282">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_2"/>
    <dbReference type="OMA" id="EPMRPGT"/>
    <dbReference type="OrthoDB" id="22486at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="271"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ71225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="395" mass="42996" checksum="A2F8747264EEFE32" modified="2013-03-06" version="1">MDEVYLVDFLRTAFSRSRPKEPDRDVFNTIRMDEALGMLIKEVVKRNNINPLDIGDVITGCALQVGENWLYGGRHPVFLAGLPVEVPAMGVDRQCASSMNAIAIGAMEIMTGNSKIALAGGMEHMTHVPMSDNPHIEINHKLLFRPDYAKYQLNIGYSMGLTAEKLAEINKISRDEMDEFSLRSHKLATEALKNGWFKGEILPIQVESKGKMITVDTDQSIRPDTTLEQLKKLPPAFKPDGVITAGNSSPLNAGASLTMLMNEKTMNEYGLKPMAKIVSIGWAAVDPSIMGEGPVPATKKALEKAKMKVEDIDYWEINEAFAVVVLNAVKKLGIDINRVNIHGGAIAIGHPLGATGARIVGTLARILKEKNARYGVATLCVGGGQGYSIIIENVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-11-13" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>U3GKD9</accession>
    <name>U3GKD9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metal-sulfur cluster biosynthetic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231728.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0037"/>
    <dbReference type="EnsemblBacteria" id="AFZ69830">
        <property type="protein sequence ID" value="AFZ69830"/>
        <property type="gene ID" value="Calag_0037"/>
    </dbReference>
    <dbReference type="GeneID" id="14211297"/>
    <dbReference type="KEGG" id="clg:Calag_0037"/>
    <dbReference type="eggNOG" id="arCOG01845">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091588_2_2_2"/>
    <dbReference type="OMA" id="LRMIIDP"/>
    <dbReference type="OrthoDB" id="113911at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="FeS_assembly_P" evidence="2">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="146" mass="16687" checksum="E625813ED7C229C3" modified="2013-11-13" version="1">MSEQIKESKRPPNLEVSGDNELIRKVEDALKEVYDPEIPVNVYDLGLVYQIEAKYVNNKPKVMIVMTLTAIGCPVTGSILAYVEEAIKDRIPDIDDNIDIEVTFEPPWNPDMVSEEGRELLKEVYGYDVVEEWKKNMQNVQQGLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7N1</accession>
    <name>L0A7N1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0089"/>
    <dbReference type="EnsemblBacteria" id="AFZ69878">
        <property type="protein sequence ID" value="AFZ69878"/>
        <property type="gene ID" value="Calag_0089"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0089"/>
    <dbReference type="eggNOG" id="arCOG03694">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2765827_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021741">
        <property type="entry name" value="DUF3311"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11755">
        <property type="entry name" value="DUF3311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="69" mass="8102" checksum="C33491805DA3CB1B" modified="2013-03-06" version="1" precursor="true">MSSRSSTIVGLVAFVTLLIFLVYAWPWYNFVKPELAGLPFFYWWIIIWYLISSILLYAIVKLRIKGEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7V3</accession>
    <name>L0A7V3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="5 9">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Calag_0168</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + NAD(+) = 2-dehydropantoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:61292"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:61294"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:16235"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="5 9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231851.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0168"/>
    <dbReference type="EnsemblBacteria" id="AFZ69953">
        <property type="protein sequence ID" value="AFZ69953"/>
        <property type="gene ID" value="Calag_0168"/>
    </dbReference>
    <dbReference type="GeneID" id="14211428"/>
    <dbReference type="KEGG" id="clg:Calag_0168"/>
    <dbReference type="eggNOG" id="arCOG04139">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_6_0_2"/>
    <dbReference type="OMA" id="NYSSMYQ"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="10">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="11">
        <location>
            <begin position="162"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ69953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="300" mass="34422" checksum="6EF9D42B5C7F2297" modified="2013-03-06" version="1">MKIGVIGCGAIGSFLSYIFKKSGYDVIAIDKIHGCKEQRVIVEKLGEENIRICGYEDIKEELDYLIFTVKAYDLDEAISLSLNNIKAKLAISTQNGLYSLEKLEKFFDAASMIIYYGIKKIEKCHSLFSGGNKIVLGCKNKNCTNEFKDFKLNEINLELVENVEPYRWEKVIINSAINPIATLYLKHNGFILENEHAYDLSLKIAEESKEIASLLNINFKRDPIKELIDTLRNTYYNYNSTLQDICLGKEKTELDYINLALYEVAKKSNYEAKYNYFAYKSVIALKNLIKANNRLCEQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7W1</accession>
    <name>L0A7W1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231819.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0133"/>
    <dbReference type="EnsemblBacteria" id="AFZ69921">
        <property type="protein sequence ID" value="AFZ69921"/>
        <property type="gene ID" value="Calag_0133"/>
    </dbReference>
    <dbReference type="GeneID" id="14211393"/>
    <dbReference type="KEGG" id="clg:Calag_0133"/>
    <dbReference type="eggNOG" id="arCOG00856">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_5_2"/>
    <dbReference type="OMA" id="YNVPIVQ"/>
    <dbReference type="OrthoDB" id="13052at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="454"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="549" mass="62134" checksum="9535B4D9B93E6572" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A824</accession>
    <name>L0A824_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RND superfamily exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231879.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0199"/>
    <dbReference type="EnsemblBacteria" id="AFZ69981">
        <property type="protein sequence ID" value="AFZ69981"/>
        <property type="gene ID" value="Calag_0199"/>
    </dbReference>
    <dbReference type="GeneID" id="14211459"/>
    <dbReference type="KEGG" id="clg:Calag_0199"/>
    <dbReference type="eggNOG" id="arCOG02175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_380670_0_0_2"/>
    <dbReference type="OMA" id="PLYGFVF"/>
    <dbReference type="OrthoDB" id="12977at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="604"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="678"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="243"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ69981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="719" mass="78956" checksum="BA09DDA377D6EB6A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8E4</accession>
    <name>L0A8E4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0346"/>
    <dbReference type="EnsemblBacteria" id="AFZ70123">
        <property type="protein sequence ID" value="AFZ70123"/>
        <property type="gene ID" value="Calag_0346"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0346"/>
    <dbReference type="eggNOG" id="arCOG00748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_2"/>
    <dbReference type="OMA" id="FIRSVYI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="103"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="303" mass="34240" checksum="861C9D748AAA1FDE" modified="2013-03-06" version="1">MKKKMSNKNEVKPDRWRELRLSLQVFFSNKAAVAGLIIFLFYFFDALILQFFPQIMPFKHPYLLTPNYANPIPQAPSWKHPFGTTYPGIDLLRAVIKSIRLDFWLSLEIVIPGAIIGLVIGIIATYFGGWVDEVLMRITDIVFSIPYLVLAIAIGYVLGRTLNSMMIALILVWWPLYARYARSVTLQTKELTFIEAARASGTSNFKIMFKHILPNSLPPVFVQISLDLGTIMLTISALAFIGFLPAANLPELGYLTSLGYEYIQTAPWAMIIPGLFIVLFALAVNLMGDGFRDVIDPRRRSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8F8</accession>
    <name>L0A8F8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231999.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0324"/>
    <dbReference type="EnsemblBacteria" id="AFZ70101">
        <property type="protein sequence ID" value="AFZ70101"/>
        <property type="gene ID" value="Calag_0324"/>
    </dbReference>
    <dbReference type="GeneID" id="14211584"/>
    <dbReference type="KEGG" id="clg:Calag_0324"/>
    <dbReference type="eggNOG" id="arCOG01431">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_1_2"/>
    <dbReference type="OMA" id="LIHPFDH"/>
    <dbReference type="OrthoDB" id="82750at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="333"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="409" mass="44339" checksum="EEE65A39314388D5" modified="2013-03-06" version="1">MNYSEQVYLDSLKALEILKDVIHITPLDYSRTFSEMTKGKIFLKLENLQKTGSFKIRGAYYKIWSLGDEKFKGVVAASAGNHAQGVALAATLQRTKSTIVMPETAPIAKINATKGYGAEVVLHGKTFDDAMSKAIELSKEKGFNLIHAYDDLKIIAGQGTIAHEILQQSPVIPDIVVIPIGGGGLISGNAIVLKKKLGNKVKIIGVEPSYIAKYSRGIKEGKPVNLKEAPPGLMDGLIVKGSGNYTFEFIKEYVDDIVKVNDSEVARAMFMLLERGKTLAEGAGAASLAAILENKIDVENKNVVALISGGNVDMTRISNILNYELAKSGRIIKLTGIIPDMPGWLDKVLEKFALAKLNVIDIRHDRMTPLIDPGTALVEVIVETPDPSVIDEVINELNSIGLKFSKALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8I5</accession>
    <name>L0A8I5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative snRNP Sm-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232034.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0360"/>
    <dbReference type="EnsemblBacteria" id="AFZ70136">
        <property type="protein sequence ID" value="AFZ70136"/>
        <property type="gene ID" value="Calag_0360"/>
    </dbReference>
    <dbReference type="GeneID" id="14211620"/>
    <dbReference type="KEGG" id="clg:Calag_0360"/>
    <dbReference type="eggNOG" id="arCOG00998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_11_1_2"/>
    <dbReference type="OMA" id="GYDVHMN"/>
    <dbReference type="OrthoDB" id="119206at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01731">
        <property type="entry name" value="archaeal_Sm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022901">
        <property type="entry name" value="snRNP_Sm-like_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="PTHR10553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="79" mass="8624" checksum="7CE6A72807FD62AB" modified="2013-03-06" version="1">MSENSHLQANTFKAMADYLNSSVLVKMKGNREVKGILTSYDQHLNLILEKAEELEGKVSRPLGLVLLRGDNVIAVSPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8P7</accession>
    <name>L0A8P7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0443"/>
    <dbReference type="EnsemblBacteria" id="AFZ70211">
        <property type="protein sequence ID" value="AFZ70211"/>
        <property type="gene ID" value="Calag_0443"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0443"/>
    <dbReference type="eggNOG" id="arCOG03878">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2009981_0_0_2"/>
    <dbReference type="OMA" id="VFRNANE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="138" mass="15956" checksum="7B35487DEAF49708" modified="2013-03-06" version="1">MREMPISTEDQSRKKLIDNIRAKIFKEYEDIQSSLVDESGLSVTTALDDFDIEKLVLDVLEEAKSPISWRDLKVIFQGIVGEDRLRRILSGLKAKNEIAELTHTRYSLPKYVPQDELNKVKNPVVMRKFEESSEEDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8T6</accession>
    <name>L0A8T6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232159.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70261">
        <property type="protein sequence ID" value="AFZ70261"/>
        <property type="gene ID" value="Calag_0495"/>
    </dbReference>
    <dbReference type="GeneID" id="14211755"/>
    <dbReference type="KEGG" id="clg:Calag_0495"/>
    <dbReference type="eggNOG" id="arCOG07462">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1551743_0_0_2"/>
    <dbReference type="OMA" id="IMELNSA"/>
    <dbReference type="OrthoDB" id="141972at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="172" mass="19131" checksum="848B19CAB92C2255" modified="2013-03-06" version="1">MSESQLVNRLETLSKSMSRKKGLSSIASVSVINILNIINRIEEINKYVECLSSNKNLCNKTDKGVLCSSDCSNTYRLVNGNETKIWKTGSNAFGFTLSSDYIELGIKDTKIEITQDKVNIKIYNNLISFPLDESGLLDNNPVIMNATNKIDEVIRHAYNGISSCARNLGLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8T7</accession>
    <name>L0A8T7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0532"/>
    <dbReference type="EnsemblBacteria" id="AFZ70293">
        <property type="protein sequence ID" value="AFZ70293"/>
        <property type="gene ID" value="Calag_0532"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0532"/>
    <dbReference type="eggNOG" id="arCOG01120">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1820924_0_0_2"/>
    <dbReference type="OMA" id="CTHVIAF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="57"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="141" mass="16405" checksum="9A7BC9B038CA35CE" modified="2013-03-06" version="1">MVMMSLGLKDSLSLKIDEQTYQETPEKWEKKVKEEGLSNKFILISKEPELWVFLGEHGDHLILSKNDTAIYCSCKGFRMEIEKKSNKGCTHVYALKIAKKFNKFRDVSANISIEELNKIIEQIMELDYSSYLRTILIKYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8W5</accession>
    <name>L0A8W5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytidyltransferase-related enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0535"/>
    <dbReference type="EnsemblBacteria" id="AFZ70296">
        <property type="protein sequence ID" value="AFZ70296"/>
        <property type="gene ID" value="Calag_0535"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0535"/>
    <dbReference type="eggNOG" id="arCOG01222">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01224">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1212640_0_0_2"/>
    <dbReference type="OMA" id="LGPDQWI"/>
    <dbReference type="OrthoDB" id="79845at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036809">
        <property type="entry name" value="AF1782-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023140">
        <property type="entry name" value="DUF357"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04010">
        <property type="entry name" value="DUF357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158372">
        <property type="entry name" value="SSF158372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF357" evidence="4">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="CTP_transf_like" evidence="3">
        <location>
            <begin position="104"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="253" mass="29170" checksum="AC3B7B25766EAAFB" modified="2013-03-06" version="1">MNKGEIMENLRSRIEKYINNVEEALKDLDSKKNLLNEKGINIENLMVNMKAYLEDAKYFLKADKLEDALVSISYSEGLIDSLKFMNLIEVKWPENPIKETRVFVAGTFDILHPGHVHLLKFASQFGKVFVVIARDINAYKNKGRPTILDENTRLEMVSSIKYVYKAMLGDENDIIKPIEIIRPDIIVLGPDQSISEEKLVSIIEARMNYKPTIIRFKEKERFSGDLRGSSDILIKGCEYLEKYGNVYKNNKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8W8</accession>
    <name>L0A8W8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotetramer of one alpha, one beta, one delta and one gamma chain.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232226.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0569"/>
    <dbReference type="EnsemblBacteria" id="AFZ70328">
        <property type="protein sequence ID" value="AFZ70328"/>
        <property type="gene ID" value="Calag_0569"/>
    </dbReference>
    <dbReference type="GeneID" id="14211829"/>
    <dbReference type="KEGG" id="clg:Calag_0569"/>
    <dbReference type="eggNOG" id="arCOG01605">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_1_1_2"/>
    <dbReference type="OMA" id="LYCPESV"/>
    <dbReference type="OrthoDB" id="125632at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011898">
        <property type="entry name" value="PorD_KorD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43724">
        <property type="entry name" value="PTHR43724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02179">
        <property type="entry name" value="PorD_KorD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="101" mass="11544" checksum="B88A6B0143673961" modified="2013-03-06" version="1">MTQNSQVIEEPKTYFLVPISKPDYGSSGKTGSWRTERPVVNEEKCTKCLYCWLYCPEDTILRREDDMVYVDYDYCKGCGICAAVCPVNAIDMVPEVKRGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Y4</accession>
    <name>L0A8Y4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <shortName evidence="8">AdoMetDC</shortName>
            <shortName evidence="8">SAMDC</shortName>
            <ecNumber evidence="8">4.1.1.50</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="8">S-adenosylmethionine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="8">S-adenosylmethionine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="8" type="primary">speH</name>
        <name evidence="9" type="ordered locus">Calag_0562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="8">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="8"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232219.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0562"/>
    <dbReference type="EnsemblBacteria" id="AFZ70321">
        <property type="protein sequence ID" value="AFZ70321"/>
        <property type="gene ID" value="Calag_0562"/>
    </dbReference>
    <dbReference type="GeneID" id="14211822"/>
    <dbReference type="KEGG" id="clg:Calag_0562"/>
    <dbReference type="eggNOG" id="arCOG00279">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125470_2_1_2"/>
    <dbReference type="OMA" id="HTWPEKG"/>
    <dbReference type="OrthoDB" id="106151at2157"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006557">
        <property type="term" value="P:S-adenosylmethioninamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00464">
        <property type="entry name" value="AdoMetDC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="PTHR33866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="SSF56276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 8" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023551084" description="S-adenosylmethionine decarboxylase beta chain" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023551082" description="S-adenosylmethionine decarboxylase alpha chain" evidence="8">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="8">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="8">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="8">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="8">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="8">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="129" mass="14501" checksum="88781AAC3E52038C" modified="2013-03-06" version="1">MQTAYRVEDDYEKKPKVVGRHIYGNIKGCKNISLLSDEKGLINLLNKAGQEGNMTILDVKAWKIGEGVSAVAIVLESHITIHTWPEYRFATVDVYSCGSHTDPKKAFDYIVNELNPEDVEFGITDRSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A978</accession>
    <name>L0A978_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with HTH domain and aminotransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0708"/>
    <dbReference type="EnsemblBacteria" id="AFZ70453">
        <property type="protein sequence ID" value="AFZ70453"/>
        <property type="gene ID" value="Calag_0708"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0708"/>
    <dbReference type="eggNOG" id="arCOG00492">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_2"/>
    <dbReference type="OMA" id="RACYVIP"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="384" mass="43242" checksum="077F89CD79705B7D" modified="2013-03-06" version="1">MDIYETLTSDIKINMAFGYPGPEPFQHKKISELSHKFINQEGEAVLQYSPATGLSYVKETVKNFLINKGIKINDEEELILTPGGTSSIYYTFFSLLNNKDFIITESPTFVGALNTIRFIKANILPIDIDIDGINVYALEEKLKQAIENRKKVKAIYLNPTAHNPTGVIMSDERRKHLIEIANKYDLLIIEDDPYGFFVFDTDKRFTSLKTLDTEGRVIYMGTFSKILAPGLRLGYIVANKAITDAIESLITMTAINPSTLSQFIAMYAIKEGVVDETIENARKVYRKKRDVLIEALEEYMPKGSEWYKPKGGLFAFVYLPKGVDTTEMLPTAINKGVAYVPGRNFFADGSGGNAMRINFSYPSIDKLREGIKIIGETAKEMMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A981</accession>
    <name>L0A981_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative metal-dependent hydrolase related to alanyl-tRNA synthetase HxxxH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232329.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0686"/>
    <dbReference type="EnsemblBacteria" id="AFZ70431">
        <property type="protein sequence ID" value="AFZ70431"/>
        <property type="gene ID" value="Calag_0686"/>
    </dbReference>
    <dbReference type="GeneID" id="14211946"/>
    <dbReference type="KEGG" id="clg:Calag_0686"/>
    <dbReference type="eggNOG" id="arCOG01254">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_3_2_2"/>
    <dbReference type="OMA" id="LMRLHTA"/>
    <dbReference type="OrthoDB" id="60779at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="240" mass="27008" checksum="1EDB69C704A33C1C" modified="2013-03-06" version="1">MATKLLFQLDSYLKEFEGKVIKIDGNKIYLDQTAFHPGPFGGLAADSGYIEVNGSKVNVIDVKMEENDEVAHYVEKPNLFSIGDIVKGYIDWEKRYAMMKLHTASHALSSVMYNKYGAKITGGHIDHNSAKDDFDLTNVSDWRKALLDAVDDTNKLLKRCANVKVYWLSKEEALKIQGIVKLAEKFPPNVEKLRIVEIEGIDIQADGGPHVKNTCEIGEIKVINVENRGKTKKRIYYTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9B2</accession>
    <name>L0A9B2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor 1A</fullName>
            <shortName evidence="1">aIF-1A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eif1a</name>
        <name evidence="5" type="ordered locus">Calag_0744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232385.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0744"/>
    <dbReference type="EnsemblBacteria" id="AFZ70488">
        <property type="protein sequence ID" value="AFZ70488"/>
        <property type="gene ID" value="Calag_0744"/>
    </dbReference>
    <dbReference type="GeneID" id="14212004"/>
    <dbReference type="KEGG" id="clg:Calag_0744"/>
    <dbReference type="eggNOG" id="arCOG01179">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109098_1_2_2"/>
    <dbReference type="OMA" id="ADITWRY"/>
    <dbReference type="OrthoDB" id="102432at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="PTHR21668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="113" mass="12787" checksum="E3451A1AFB9C82A5" modified="2013-03-06" version="1">MKINLVKQKNSNNSKGEMPLPNDEEGTMICVVQKVIGAGFLEVVCTDGNKYKAWIPGKMRRRIWLHEGDTILFLPWGTSDMKGEVVHKYQQNEVRELIQKGLLSKDLLGEESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9C2</accession>
    <name>L0A9C2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232369.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0726"/>
    <dbReference type="EnsemblBacteria" id="AFZ70471">
        <property type="protein sequence ID" value="AFZ70471"/>
        <property type="gene ID" value="Calag_0726"/>
    </dbReference>
    <dbReference type="GeneID" id="14211986"/>
    <dbReference type="KEGG" id="clg:Calag_0726"/>
    <dbReference type="eggNOG" id="arCOG02459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_803158_0_0_2"/>
    <dbReference type="OMA" id="DASVITW"/>
    <dbReference type="OrthoDB" id="139135at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_su_c/d_dom_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="345" mass="38952" checksum="973DC910F0A72410" modified="2013-03-06" version="1">MGSPSTYAKIVPRLRYLKSTLIPSDKLRELSPPISDIYAFLRESKYRSVSDTKSPEDAEKEIMKRFYSAIDEIAALTPSEAMDLTLSFAKEDEINDSLLVLRSIIENKEVNKSTLISLLWSQSSLNKILAEPDSLAGVQRYLEISSKFKHIYNSLKDAYTFYNELKDASVITWYSLAATSNLYSESISKLNSIDKDAVSKTLCPIIEGKIALGLIQSSLLKIPIRVVEASFMKIKACNISWNKIGNIYERESGDPMALATSLRDQFKYLKIEGRKENEIMDSIRKSSYISAKRKAEATFQSYPFSPSLISAALILLKLEVNNLKTIVISSYLKLSKEEYENLLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9G0</accession>
    <name>L0A9G0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232430.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0791"/>
    <dbReference type="EnsemblBacteria" id="AFZ70533">
        <property type="protein sequence ID" value="AFZ70533"/>
        <property type="gene ID" value="Calag_0791"/>
    </dbReference>
    <dbReference type="GeneID" id="14212051"/>
    <dbReference type="KEGG" id="clg:Calag_0791"/>
    <dbReference type="eggNOG" id="arCOG05388">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2140235_0_0_2"/>
    <dbReference type="OMA" id="TSSVKPW"/>
    <dbReference type="OrthoDB" id="107975at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="117" mass="13790" checksum="B16E538D755FA09C" modified="2013-03-06" version="1">MRDIKNLNTLEKYILVHIYRFGPDTPWLMAHRLLGNYGYSAKYDPDEIEKNCKTLEEEGLLVVYKGELKMKVTSSIKPWLKVKSKEFKHKPSGIYYDLSKEGRKVASNLYKEIFKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9H3</accession>
    <name>L0A9H3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231967.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0289"/>
    <dbReference type="EnsemblBacteria" id="AFZ70069">
        <property type="protein sequence ID" value="AFZ70069"/>
        <property type="gene ID" value="Calag_0289"/>
    </dbReference>
    <dbReference type="GeneID" id="14211549"/>
    <dbReference type="KEGG" id="clg:Calag_0289"/>
    <dbReference type="eggNOG" id="arCOG01143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074761_0_1_2"/>
    <dbReference type="OMA" id="YYDAARH"/>
    <dbReference type="OrthoDB" id="82715at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="254" mass="29346" checksum="DE150B82056B3554" modified="2013-03-06" version="1">MKILLISDIHGNIEPFNEIVKNENFDEVLFLGDAVDYGPKPAEVIDKLKELGAKSVLGNHDNALIYNIDCMCGEATHWISVYFRENYTKKMVNRSQIDYLKNFKIKLEIDIDGFGKGLLTHGSPSNPLYGYLYPWLSDDNITKMLYKELRLKSDENKTPKLAYDIYLIGHTHYQFMKKINNSIIINPGSAGEPRDNDYRAAYAIIDTETKNIILKRIKYNVDKVIRNLEDLKIPNPYLTHLKYMFINGSVLMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9I8</accession>
    <name>L0A9I8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231695.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0001"/>
    <dbReference type="EnsemblBacteria" id="AFZ69797">
        <property type="protein sequence ID" value="AFZ69797"/>
        <property type="gene ID" value="Calag_0001"/>
    </dbReference>
    <dbReference type="GeneID" id="14212759"/>
    <dbReference type="KEGG" id="clg:Calag_0001"/>
    <dbReference type="eggNOG" id="arCOG00467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025112_3_1_2"/>
    <dbReference type="OMA" id="DMLGIIN"/>
    <dbReference type="OrthoDB" id="58376at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="54"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="5">
        <location>
            <begin position="309"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="411" mass="46624" checksum="FD307DFAAC42A116" modified="2013-03-06" version="1">MSEIDDIFNAAYKPRVFKRREVLLPDYVPEFLPHRDDETKRVALTLSPALRMERPSNIFIYGLTGTGKTAVTKFVLRKLEENAKQKGIKVGYIYANVRHRETPYRILADIADYFNMRIPFTGLSTGEVFNRIVKKLTNLEGVYIIVLDEIDFLVKKYGDDLLYNLTRINEQLSKSRVSIIGITNSVKMIESLDPRVKSSLSEEEIVFSPYDAKQLQDILNQRAEEAFNERALDEEVIPLCAALAAREHGDARRALDLLRVAGEIAERENRNVVTKDDVMKARVEIERDRVGDVVKTLPLHGKLIMTSILLATAMGKDYATTGDIYDNYKKLISKLGLEEITLRRVSGILSELDMLGIISGRIISRGRYGKTRVISLAAEVNAIIQALKEDPMIADLLNEVKYDDNRKNNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9I9</accession>
    <name>L0A9I9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232460.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0822"/>
    <dbReference type="EnsemblBacteria" id="AFZ70563">
        <property type="protein sequence ID" value="AFZ70563"/>
        <property type="gene ID" value="Calag_0822"/>
    </dbReference>
    <dbReference type="GeneID" id="14212082"/>
    <dbReference type="KEGG" id="clg:Calag_0822"/>
    <dbReference type="eggNOG" id="arCOG01324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_0_1_2"/>
    <dbReference type="OMA" id="CSIYVHE"/>
    <dbReference type="OrthoDB" id="92495at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="4">
        <location>
            <begin position="15"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="231" mass="25440" checksum="4B224EC3FFF1C5B0" modified="2013-03-06" version="1">MKKVYHLDADEVPNRVIIMGDPQRVINLSLLLENPVEISKSRNLFIYKGYYNNKEVALASHGIGGPSAAIVIEELIKLGANVLIRLGTVGSLKKEIDVGDVIIPTGASYWHGGAGLGMYFNNICPPTNPSYDLVYDLIKEINNNQIRYHVGSIFSSDSFYAEKDYIDILIKLNFIGIEMECATLFAISNLRGVKSACSLVTSNNLIKGTKGDYNDVVKRIAKIILNVITSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9K1</accession>
    <name>L0A9K1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0016"/>
    <dbReference type="EnsemblBacteria" id="AFZ69812">
        <property type="protein sequence ID" value="AFZ69812"/>
        <property type="gene ID" value="Calag_0016"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0016"/>
    <dbReference type="eggNOG" id="arCOG04060">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077869_0_0_2"/>
    <dbReference type="OMA" id="KMAGEIT"/>
    <dbReference type="OrthoDB" id="55424at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017271">
        <property type="entry name" value="Tscrpt_reg_HTH_MJ1545_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037724">
        <property type="entry name" value="TF_HTH_MJ1545_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="250" mass="27961" checksum="B458BE2F007F17CB" modified="2013-03-06" version="1">MEESFQNFIADLIARRISGDIVYSNNPNIGLKKWRDYFEVSQLEVARIMGVSASVISDYEKGRRVPGAKFIQRYVRALLTIDHQRGWKKLDALSKALGIPRRAIIDMMEFNEPITIGDLISLVDGILLSPNYADSIRVYGYTLIDSIRAIAELSGPQFYFLLGSTPERAIIFTNVTAGRSPMVAIRVSLVKPGIIIIHGPRRYVDPLAIELARLEGLPLILSLAKDINTLIRKLRSKAGSDETNFLSVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9K9</accession>
    <name>L0A9K9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232453.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0815"/>
    <dbReference type="EnsemblBacteria" id="AFZ70556">
        <property type="protein sequence ID" value="AFZ70556"/>
        <property type="gene ID" value="Calag_0815"/>
    </dbReference>
    <dbReference type="GeneID" id="14212075"/>
    <dbReference type="KEGG" id="clg:Calag_0815"/>
    <dbReference type="eggNOG" id="arCOG03129">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_893170_0_0_2"/>
    <dbReference type="OMA" id="TEITEYH"/>
    <dbReference type="OrthoDB" id="120026at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="299" mass="35181" checksum="9F72E0510BF2246E" modified="2013-03-06" version="1">MFERVILRLVKKKIYNEVYEEVYPGKNVLFGNEIFTIKTYDSDLEYLLIQKIGYPEVYKYNGTIKLITENINSFCEWHNGPLDEVDDPTKRFYCPISSEGFCSKHKRSDRAIYSLCLSYRGEKALEACKTIDKKITKGEYIVYLIDYGGQLPKVGTTRKFRLLERIAEQPHIIATQLYLTDSLYKARLMEMNISKSGLANELWRHRWISTENLYNSIIKIKDMADKILKKFDIKEEIKLFRIRQPKINFIQGDLSNKELKLNGAWGGYLILSDMKYNYIYSESQLLHKDSILINNEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9M3</accession>
    <name>L0A9M3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">flpA</name>
        <name evidence="5" type="ordered locus">Calag_0322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231997.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0322"/>
    <dbReference type="EnsemblBacteria" id="AFZ70099">
        <property type="protein sequence ID" value="AFZ70099"/>
        <property type="gene ID" value="Calag_0322"/>
    </dbReference>
    <dbReference type="GeneID" id="14211582"/>
    <dbReference type="KEGG" id="clg:Calag_0322"/>
    <dbReference type="eggNOG" id="arCOG00078">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059055_2_0_2"/>
    <dbReference type="OMA" id="INMATHR"/>
    <dbReference type="OrthoDB" id="58340at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="230" mass="26711" checksum="0E586DCED21F8734" modified="2013-03-06" version="1">MEIREHENWKNVYIIEQEDGTYKLATKNLVKGQRVYGEKLYQYNDVEYREWNAYRSKLAAALLKGLEELPIKEKDRILYLGIASGTTASHISDIIGNEGLIFGIEFSPRVIRDLLLIVNDRKNIFPILADARFPENYRHMIETVNGLYADVAQPEQAQIVSRNAKFFLKDGGYLLLAIKARSIDVTKEPNEIYKMETEELVRNGFEIKDIIHLDPFDKDHAMIYGIYHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9N1</accession>
    <name>L0A9N1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family hydrolase, diadenosine tetraphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231750.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0061"/>
    <dbReference type="EnsemblBacteria" id="AFZ69852">
        <property type="protein sequence ID" value="AFZ69852"/>
        <property type="gene ID" value="Calag_0061"/>
    </dbReference>
    <dbReference type="GeneID" id="14211321"/>
    <dbReference type="KEGG" id="clg:Calag_0061"/>
    <dbReference type="eggNOG" id="arCOG00419">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1598929_0_0_2"/>
    <dbReference type="OrthoDB" id="127781at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="166" mass="19140" checksum="ECCD9274ACE8224E" modified="2013-03-06" version="1">MEDVFCRIAKGEEKSYTVYSDDKIMVIMDIYPMSKGQTLVIPKKHFVFFYEMPDDLIYSFYKTVNIIGKAMIKAFNPKAIALIARGLRVPHYHLILVPIRDGDINDKYFSVMDAYQGFPKVSSDVLLARIEDFKSLAMKGRPQVSEDELIDDMNKLKISLKEIQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9N2</accession>
    <name>L0A9N2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0332"/>
    <dbReference type="EnsemblBacteria" id="AFZ70109">
        <property type="protein sequence ID" value="AFZ70109"/>
        <property type="gene ID" value="Calag_0332"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0332"/>
    <dbReference type="eggNOG" id="arCOG01606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_1_0_2"/>
    <dbReference type="OMA" id="EFWSNIA"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="6">
        <location>
            <begin position="15"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="7">
        <location>
            <begin position="252"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="8">
        <location>
            <begin position="528"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="643" mass="71174" checksum="0C6ABE7F0D4BB65A" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9P0</accession>
    <name>L0A9P0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232017.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0342"/>
    <dbReference type="EnsemblBacteria" id="AFZ70119">
        <property type="protein sequence ID" value="AFZ70119"/>
        <property type="gene ID" value="Calag_0342"/>
    </dbReference>
    <dbReference type="GeneID" id="14211602"/>
    <dbReference type="KEGG" id="clg:Calag_0342"/>
    <dbReference type="eggNOG" id="arCOG03705">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1465195_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="184" mass="21160" checksum="170F4370FA452BC2" modified="2013-03-06" version="1">MDRALYIIENNKYSVSDLDRLKERLMDLGCPHGIRISITHIEVVVFCKDSKIIRDKITKALGSRIIDVFIGEPEVKEGKELSNFIDFLDNELFWLAHTFMETPWKNHNDKRLQSLVLYAGALAKAQENELKASLNLLNMAKDFGAEELIDLNCAKKQIDLILKNKRTNASSCLNLEKIRELLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9P6</accession>
    <name>L0A9P6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine recombinase XerA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xerA</name>
        <name evidence="7" type="ordered locus">Calag_0353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 'phage' integrase family. XerA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232027.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0353"/>
    <dbReference type="EnsemblBacteria" id="AFZ70129">
        <property type="protein sequence ID" value="AFZ70129"/>
        <property type="gene ID" value="Calag_0353"/>
    </dbReference>
    <dbReference type="GeneID" id="14211613"/>
    <dbReference type="KEGG" id="clg:Calag_0353"/>
    <dbReference type="eggNOG" id="arCOG01242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_2_2"/>
    <dbReference type="OMA" id="ERMVYFD"/>
    <dbReference type="OrthoDB" id="57897at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02055">
        <property type="entry name" value="Recomb_XerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033686">
        <property type="entry name" value="XerA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0229">DNA integration</keyword>
    <keyword evidence="2 3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="14"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="117"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="3">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="318" mass="37180" checksum="3403B13820A7A17D" modified="2013-03-06" version="1">MSKIDLPKIKSNISSIKEAFNLFIKSMEVSGASPLTIKSYKVAIQNFINFIGENKRIDEINYDIYANWINYLKKNMSKRTKRNYEATIHYYSIFVRRFLNWIGTDQELPIMSLRRQTFSEALTWEEVTKLISSVRDLDDLLIVSILSETGLRVRELLNLTWDDINLDTGQIRVIGKYNKERIVFIGPLSRQALIEAYNLYGNKRKNIIDLTYQAVYKRLKSLAVRAGLDPRKVRPHIIRHTFATEALRRGMSLPALQRLLGHSDIKITQLYLHLVNDDVRREYNRLFSQQNYIQDNNAFQPYYINPQSYNKGKGFAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9R6</accession>
    <name>L0A9R6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232530.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0893"/>
    <dbReference type="EnsemblBacteria" id="AFZ70633">
        <property type="protein sequence ID" value="AFZ70633"/>
        <property type="gene ID" value="Calag_0893"/>
    </dbReference>
    <dbReference type="GeneID" id="14212153"/>
    <dbReference type="KEGG" id="clg:Calag_0893"/>
    <dbReference type="eggNOG" id="arCOG00082">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_0_1_2"/>
    <dbReference type="OMA" id="CETPTGT"/>
    <dbReference type="OrthoDB" id="20398at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="31"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="385" mass="43562" checksum="EAB1714A25EFC837" modified="2013-03-06" version="1">MIKYYTDEILMTPGPTQISLDIYKSMITKAKNTDLDEDFINFYNDLRKKVFNLLNMKKGDIYIMLGEAMLGLEIAVANTVKEGDKVLIIDNGVYGDGFKDLVKMYRGIPITMGLDWRKEADPNEIDKAFEKNKDISLATLVHCDTPSGMLNNLNEISKIVKSHDSYLIVDAVSSIATTNVEFQNIDILIGGSQKALNIPAGLTIMAISEEIWEKIKKVNYQGYYMNLSLWKEMFDYNKTFPYTMNDTLIYALNTSIDKLFEEGLENVYKRHELAKRASLNALKSLNLELYPEDERYSSPSVTAFLLPQGINDKKLREITWKKYGVMIAGSWGKLEGKVARIGHMGYQASLNNLLIAYSSLSKALNELGYKNSVSEVLGSIEEVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9T3</accession>
    <name>L0A9T3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232550.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0922"/>
    <dbReference type="EnsemblBacteria" id="AFZ70653">
        <property type="protein sequence ID" value="AFZ70653"/>
        <property type="gene ID" value="Calag_0922"/>
    </dbReference>
    <dbReference type="GeneID" id="14212182"/>
    <dbReference type="KEGG" id="clg:Calag_0922"/>
    <dbReference type="eggNOG" id="arCOG01400">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_945272_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="294" mass="34195" checksum="183B3494F6A43311" modified="2013-03-06" version="1">MDNGLIIEDGFNNNYEMQTLKYLLNTKFLETIKSFDIILKYNKSKSRKVKLKFNNKIYYADFPTLKSILYAKIFGYNIESNEIIVNFLKYKIGIPINKIAGLDPLWEYIKMLINCKKHNNNCPYPTKVKGYDIIDIGGYIGDSALFFYNFGANHVKVYEPVYYDLAAKNLERNGLPIDVEAKSVGYDKEMCVSEDLNATGLRKGNLCFQLITPEEIIQDNYDLVKMDCEGREISLVNTPCSYLNRVNSYVMEVHFSYDNVTKIIDKFKLCGFNRFRVVRITPNGFLHYLYINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9T9</accession>
    <name>L0A9T9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cystathionine beta-lyase/cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232082.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0415"/>
    <dbReference type="EnsemblBacteria" id="AFZ70184">
        <property type="protein sequence ID" value="AFZ70184"/>
        <property type="gene ID" value="Calag_0415"/>
    </dbReference>
    <dbReference type="GeneID" id="14211675"/>
    <dbReference type="KEGG" id="clg:Calag_0415"/>
    <dbReference type="eggNOG" id="arCOG00060">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_2"/>
    <dbReference type="OMA" id="MQTKLIH"/>
    <dbReference type="OrthoDB" id="55005at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="386" mass="43451" checksum="8B12B645DC54F37D" modified="2013-03-06" version="1">MGDSTKSINSEYSDEFGSIIPPIYISSIYRYIDEDTSKKSDRNITIKYYREENPSLRILEKVLSSLEGSEDSLVFSSGMAAISTIAMNFLKKKSKVLLLKEMYGSTIQLFENLSNKFDITIKKVYPNHENIIEELEKNTYDLAIIESITNPTLKVIDISKIGDIIKKLDTNVVVDNTFATPILLKPSKYGFKLILNSTTKYLSGHNDTMGGSISGKSDLINELWEWRRLLGNIQQPFEAYLTLRGIKTLPIRIKQQSENALAISEFLADNSKISRVLYPGLKDSEYNKIALKIFEKPYFGGVLSFEIKGDLNQAKDFLRNLKIIKPSPSLGGTESIATLPSITASRYIDESDKKELGISEKLIRLSVGLEDTDDLINDIQQALNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9W4</accession>
    <name>L0A9W4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0441"/>
    <dbReference type="EnsemblBacteria" id="AFZ70209">
        <property type="protein sequence ID" value="AFZ70209"/>
        <property type="gene ID" value="Calag_0441"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0441"/>
    <dbReference type="eggNOG" id="arCOG07221">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171532_0_0_2"/>
    <dbReference type="OMA" id="VCRHDWA"/>
    <dbReference type="OrthoDB" id="123679at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="112" mass="12706" checksum="D1A7EA4F0100DF50" modified="2013-03-06" version="1">MNQSRSICDICGINEAIYKCKICKRNVCYDDFDEERGVCKICAASLCQICNSRLSVTYCPYCGRLVCIEDSIQLDNVRRVCIDCYKKGAIKLSKNLKYVDGAIKLSKRVKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9X5</accession>
    <name>L0A9X5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232595.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0975"/>
    <dbReference type="EnsemblBacteria" id="AFZ70698">
        <property type="protein sequence ID" value="AFZ70698"/>
        <property type="gene ID" value="Calag_0975"/>
    </dbReference>
    <dbReference type="GeneID" id="14212235"/>
    <dbReference type="KEGG" id="clg:Calag_0975"/>
    <dbReference type="eggNOG" id="arCOG00131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051127_0_0_2"/>
    <dbReference type="OMA" id="YSTPMNL"/>
    <dbReference type="OrthoDB" id="34279at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="234"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="421" mass="48034" checksum="651935011FD92E8A" modified="2013-03-06" version="1">MEKIKYNDKWMYTLIPYGMGFMPFLIMLPLLILKLGGNAIDISYTATLGNITWIIGSFVWGYISDYYDLKKLTILGLLTSGLFVIPMAYAKSVVEVEILYGIWSFFNTALIISLYLIIIKTFAKEMWVIENAKLNFLNTIGYLLGFLGSSALAIYFKVNFLILMTGILMTLSSLLSYYFLPKIENNHKELSWINVLKSFLIKIRIMSKIFNPSFLKISLKKAFDFKNKKIQNMRIILLYTGNFLFYLSYGIILTQYSASLKIYGISDSIILAIFSLGTFSQIISFYFSPRFINTYGKIRASWITLSLRGISFFMIGLSMFLFLNKTYLILSQFVFYSLGGGLAYSIFFTAANVMVLETTKTEKEGSTLGIYETLIAFGFTIGSFISGYMINYTGFPITFIITGILIIINSAIFKIMEEKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Z1</accession>
    <name>L0A9Z1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232137.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0473"/>
    <dbReference type="EnsemblBacteria" id="AFZ70239">
        <property type="protein sequence ID" value="AFZ70239"/>
        <property type="gene ID" value="Calag_0473"/>
    </dbReference>
    <dbReference type="GeneID" id="14211733"/>
    <dbReference type="KEGG" id="clg:Calag_0473"/>
    <dbReference type="eggNOG" id="arCOG01710">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128233_0_0_2"/>
    <dbReference type="OMA" id="VYTGLHQ"/>
    <dbReference type="OrthoDB" id="89832at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="146" mass="16091" checksum="C8686987F3BCC9CF" modified="2013-03-06" version="1">MLSPQYTKTEQFKVLVAKLGIDGHDRGAKVIARALKDAGFEVIYTGIRQTPQQIVSSALQEDVDVIGISILSGAHIHHMKMLMEELKNAGASDIPVVIGGTIPIIDVDELKKIGVREVFLPGESLRKIVEIIRKLAEEKRKLELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Z8</accession>
    <name>L0A9Z8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <shortName evidence="4">HK</shortName>
            <shortName evidence="4">HSK</shortName>
            <ecNumber evidence="4">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thrB</name>
        <name evidence="7" type="ordered locus">Calag_1000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232620.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1000"/>
    <dbReference type="EnsemblBacteria" id="AFZ70723">
        <property type="protein sequence ID" value="AFZ70723"/>
        <property type="gene ID" value="Calag_1000"/>
    </dbReference>
    <dbReference type="GeneID" id="14212260"/>
    <dbReference type="KEGG" id="clg:Calag_1000"/>
    <dbReference type="eggNOG" id="arCOG01027">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_1_1_2"/>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="OrthoDB" id="91752at2157"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="83"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="6">
        <location>
            <begin position="212"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="318" mass="34256" checksum="A2A3BBEA1BFF9D54" modified="2013-03-06" version="1">MEEVWAKAYSSSANLGPGFDVLSLAHDAYYDVVSISAKNGAGDIKVEKIDGPFSSNVSENNSASYAIRYMMNDLKLNNYDISIKIWKGIPVSSGLGGSGASAAAAVFALSNVLDLGLKREELIKYAGQGEIVSAGVPHYDNVSASLLGKLVVVGNIDDNILAYSFDINASFIIFRPINYYLENKTQYMRSLLPKFVEFKHHIHDTANLGILISSLLKGDLKAAGKAMNDTIVTNARAKAVPCFMEIKEALHNEGAYGVAISGAGPSIIVLYEKNAENLINTGLNIYKKCNINAEAKIVRPAQGTKILYGDNWGFSESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA04</accession>
    <name>L0AA04_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA wyosine derivatives biosynthesis protein Taw3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">taw3</name>
        <name evidence="7" type="ordered locus">Calag_0488</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TYW3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232152.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0488"/>
    <dbReference type="EnsemblBacteria" id="AFZ70254">
        <property type="protein sequence ID" value="AFZ70254"/>
        <property type="gene ID" value="Calag_0488"/>
    </dbReference>
    <dbReference type="GeneID" id="14211748"/>
    <dbReference type="KEGG" id="clg:Calag_0488"/>
    <dbReference type="eggNOG" id="arCOG04156">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047426_2_1_2"/>
    <dbReference type="OMA" id="GFKYTTF"/>
    <dbReference type="OrthoDB" id="118297at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00266">
        <property type="entry name" value="TYW3_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022908">
        <property type="entry name" value="Taw3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSF111278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TYW3" evidence="6">
        <location>
            <begin position="13"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="188" mass="21510" checksum="F2A82173C353C959" modified="2013-03-06" version="1">MSISKKIEDILRQERIIGYLDPNAENYILALNNENFSTSSSCIGRITIIEGDWPWERDRSRVVYKTHNHLSIYELANVLSRPFDNLWLKITGPIIHLRTEKINCALNILNIARTSGFKHSGIISSSDNIFTVELMSAVEITQPLKINNTFIFNINSLSNIINKSNKALDEGHRRLEKLTNLIKKNLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA30</accession>
    <name>L0AA30_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L24p/L26e, archaeal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0515"/>
    <dbReference type="EnsemblBacteria" id="AFZ70279">
        <property type="protein sequence ID" value="AFZ70279"/>
        <property type="gene ID" value="Calag_0515"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0515"/>
    <dbReference type="eggNOG" id="arCOG01920">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113589_0_0_2"/>
    <dbReference type="OMA" id="FSEIEHF"/>
    <dbReference type="OrthoDB" id="122836at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011590">
        <property type="entry name" value="Spt5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00405">
        <property type="entry name" value="KOW_elon_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="NGN" evidence="3">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="155" mass="17228" checksum="AE293E30C5CD0370" modified="2013-03-06" version="1">MSISNQTQKNKIYAISVVGGYEEKIALIFAERAQSLKLDIKSIVYSEDLKGTVIVEIGDPKDLFYLIRGIKNVKRRRPIAISLQDVIKLLKPPTALPTIAKGQLIEVIGGPFKGMKGRIVEVYATRNEADITLLEGDSKIVVTIPTEYIKVTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA44</accession>
    <name>L0AA44_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231895.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0215"/>
    <dbReference type="EnsemblBacteria" id="AFZ69997">
        <property type="protein sequence ID" value="AFZ69997"/>
        <property type="gene ID" value="Calag_0215"/>
    </dbReference>
    <dbReference type="GeneID" id="14211475"/>
    <dbReference type="KEGG" id="clg:Calag_0215"/>
    <dbReference type="eggNOG" id="arCOG01707">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_2"/>
    <dbReference type="OMA" id="RDVKLNQ"/>
    <dbReference type="OrthoDB" id="36092at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="119"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="225"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ69997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="385" mass="42539" checksum="6EBB99FBF5205E7D" modified="2013-03-06" version="1">MSAKSDIDLLRSSVREFSEKVLMPVAKKIDAENFISEDILNQVANMGYFALRVPDKYGGPNLSTLESAIVVEELARASGAVAIMATVSGTMVAYPLVHYASEELKEEYLGRLSKGKIGAFALSEPCCGSDAANITTKAEIDGNDYVINGRKTWITNSTYADFFLVAARTGKQEDRHKGITIFVVDNKDCIEKSKLDMMGYRGSGTSELLFKDCRVPKENIVGEVNNGFKIIIDGLNEGRIITASTGLGIMQAAFDESLNYAKIRETMGKPIIEHEMVQSMIADMKVKLEASRLLIYNAAQKIDNNEIDYPMWSSIAKYATAKWGVDVVRLAMQVEGGFGYSKESNVERYYRDIKMIEIGDGTNEIQKLVISRSLAGKITSPRLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA61</accession>
    <name>L0AA61_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative metal-dependent protease of the PAD1/JAB1 superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231910.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0230"/>
    <dbReference type="EnsemblBacteria" id="AFZ70012">
        <property type="protein sequence ID" value="AFZ70012"/>
        <property type="gene ID" value="Calag_0230"/>
    </dbReference>
    <dbReference type="GeneID" id="14211490"/>
    <dbReference type="KEGG" id="clg:Calag_0230"/>
    <dbReference type="eggNOG" id="arCOG01138">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116765_4_2_2"/>
    <dbReference type="OrthoDB" id="101895at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prok-JAB" evidence="6">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="128" mass="14580" checksum="D22A62EA837F7147" modified="2013-03-06" version="1">MKIVLGNLSIFLNLLLKFEEESAGLLIGSTKDDIIYPIIAMPVENVLKSRVEFLANPYDMVVGHMVAENYKLSVVSLYHTHPYGMPIPSNKDINGMKMWPIPWIIISRKGIRAWILKEDDKPIELELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA72</accession>
    <name>L0AA72_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major Facilitator Superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231843.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ69945">
        <property type="protein sequence ID" value="AFZ69945"/>
        <property type="gene ID" value="Calag_0159"/>
    </dbReference>
    <dbReference type="GeneID" id="14211419"/>
    <dbReference type="KEGG" id="clg:Calag_0159"/>
    <dbReference type="eggNOG" id="arCOG05835">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705159_0_0_2"/>
    <dbReference type="OMA" id="TGPAFWT"/>
    <dbReference type="OrthoDB" id="22091at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="391" mass="43569" checksum="83E3E806A9F09D05" modified="2013-03-06" version="1" precursor="true">MNKTRKWAYSLLGFVIASLLTSALSIYVLFMPYFSEKIGVNIQELILWGNLAYFIGMPIGKIIGRFLKFYKRLTKSIIGLTGLISISIALMPFISSFSELIILRIIQGTVTFYMEIFSNVYSFLFSDFKSRNLASAISISGIPGGVAIGTSAYILETQSPILVYSIFSIISFIVGLIFAFSTLNFENTIKELKNEYKGTTYKLKITWIMGFYWATIAGFNLVLAILLQPFVSSYSVKDVPIAMETFGYSGAILTIAGGFIAYLTKSLKITSIVIGISYIISFIGFLILYLFEPVGIYLALTIILIMIEAIAVPFIYSIPREIYKENMVAKGTWEFAFIGSSFHIWGALIVLTIGSLISFRYSILALAFPPIYGALISFLIPRFSIKGDKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA87</accession>
    <name>L0AA87_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232237.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0581"/>
    <dbReference type="EnsemblBacteria" id="AFZ70339">
        <property type="protein sequence ID" value="AFZ70339"/>
        <property type="gene ID" value="Calag_0581"/>
    </dbReference>
    <dbReference type="GeneID" id="14211841"/>
    <dbReference type="KEGG" id="clg:Calag_0581"/>
    <dbReference type="eggNOG" id="arCOG01394">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873241_0_0_2"/>
    <dbReference type="OMA" id="FLHWKEQ"/>
    <dbReference type="OrthoDB" id="64042at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="1">
        <location>
            <begin position="194"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="327" mass="36626" checksum="D3905D09B41D40B8" modified="2013-03-06" version="1">MKKVLIIASGGGHTGHSIALAEYLIDMGIEVDFIIPENDTWTRNSVINYGNVVSETPKFLDPSESLYKGILRAPIAIIKSLAKVKSGYKLVIASGSNHSISTGLALWLKGSDIIVFESTERFLEPSRTIKTLGKISKLIAFQWEEQLKFNDKKGKVVGPFLGKLKYNIKDEGYILVSAGSYGYKKLFDALSKTNLENIVLQTGKVDPKPYIASHPEWKVFQFDPNLEKYIASASIVITHFGRTAVESALKYKKPTILAPNIEWKWMQNEIRIKESEIMAKKLNAYYLPPNSLNENSIMEAIKYTKNLIPYSYNDGALELAKIVNSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA94</accession>
    <name>L0AA94_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231940.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0261"/>
    <dbReference type="EnsemblBacteria" id="AFZ70042">
        <property type="protein sequence ID" value="AFZ70042"/>
        <property type="gene ID" value="Calag_0261"/>
    </dbReference>
    <dbReference type="GeneID" id="14211521"/>
    <dbReference type="KEGG" id="clg:Calag_0261"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="TFCARMY"/>
    <dbReference type="OrthoDB" id="71942at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="312" mass="35741" checksum="3FDAC5517C5F579A" modified="2013-03-06" version="1">MTDAIVVENLKHTYDGKKYVLDDISFTVKKGEVFGLLGRNGAGKTTTIKILTTLIMPTKGNVNILGYNIRKDGLEIRKRIGLVQQLPSIEFTSVEKNFDIYGILWGLGKKEIKRKTEELLKIFDLEQVRKKNVLDLSGGERRRIQVAREFLHDMDILFLDEPTVGLDVVMRRNLLNYIKKMVNRGLTIVFTTHMLEEAEYLCDRIAVIDKGKIVAMDTVENLKAKYGGKKTVEFIIKGVNQEKIIDKINDSKNLVKMNENKLIILTENPYEVVETIIDEVRKINGRIEWLNIRENTLEDVFLNVIGEENGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAC7</accession>
    <name>L0AAC7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231893.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ69995">
        <property type="protein sequence ID" value="AFZ69995"/>
        <property type="gene ID" value="Calag_0213"/>
    </dbReference>
    <dbReference type="GeneID" id="14211473"/>
    <dbReference type="KEGG" id="clg:Calag_0213"/>
    <dbReference type="eggNOG" id="arCOG08457">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2079299_0_0_2"/>
    <dbReference type="OMA" id="KEFRTIF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="117" mass="14027" checksum="F111A2182FB55E1A" modified="2013-03-06" version="1">MYISRRNNERNDREERKNKGFEKKDRRDANGYISNGIHKEYNNRIYDDSCKELLQMLVEVSSEEASLTFKLYKLREEAKYLALELSGLLSQYKLLGGDYKEFRTIFNSMFEKYVEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAI8</accession>
    <name>L0AAI8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-aminobutyrate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232342.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0699"/>
    <dbReference type="EnsemblBacteria" id="AFZ70444">
        <property type="protein sequence ID" value="AFZ70444"/>
        <property type="gene ID" value="Calag_0699"/>
    </dbReference>
    <dbReference type="GeneID" id="14211959"/>
    <dbReference type="KEGG" id="clg:Calag_0699"/>
    <dbReference type="eggNOG" id="arCOG00915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_2"/>
    <dbReference type="OMA" id="DVFPRFA"/>
    <dbReference type="OrthoDB" id="20774at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="448" mass="49383" checksum="8025233B362EBE2F" modified="2013-03-06" version="1">MERVPDIKVEPPGPEARNVIEKDQKLLMQSYVRWYPLVIKTGHGAVVEDVDGNKYIDMNAGIAVMALGHNHPKVVEAIKREAEKLQHYSLTDFYYEEAVTSAEKLLSVVPIKNGKVFYTNSGTESIEGALKIARYYHEGKRQYIIAFLGAFHGRTMGSLSLTASKAHYREHFAPLVPGVIHVPYPYTYRCPFNTDDPKACGEAVLGYIEDWIFTKLVEPSEVAAIFVEPIQGEGGYIVPPDNFLPGLRKLADKYNILLVDDEVQSGIARTGKWFAIENWNVVPDIIAMAKAIGGGLPLGAIVAKDNVMDAMKKGSHANTFGGNPIALAAMEAVIDTIKEEKLTERAAKLGDMVLRYFNDLKEELEIIGDVRGKGLMIGVELVKNKKTKEPASKELGRILDKSFKKGVLVIGSGVSSIRIAPPLVIDEDVLARAIQILGDILKEENKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAK6</accession>
    <name>L0AAK6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232025.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0351"/>
    <dbReference type="EnsemblBacteria" id="AFZ70127">
        <property type="protein sequence ID" value="AFZ70127"/>
        <property type="gene ID" value="Calag_0351"/>
    </dbReference>
    <dbReference type="GeneID" id="14211611"/>
    <dbReference type="KEGG" id="clg:Calag_0351"/>
    <dbReference type="eggNOG" id="arCOG02037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1131550_0_0_2"/>
    <dbReference type="OMA" id="WIMAYKA"/>
    <dbReference type="OrthoDB" id="130468at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="249" mass="28755" checksum="001AFEC176E2946F" modified="2013-03-06" version="1">MGEDLEKIKNKIKETLKLNKYETNAYFTLLKLGKSRPTDIAKNSNIPIQRIYDVLKSLEKKGLITTKDQIYYEILEPSLSFQTIAQNLIADANIKAREIENIGQFLSGITTIKTIDEIKIIYGVKETIGNTITYVKNCNEKPYFMVYKVLDKLLDLWPLLYEIISTTKNGAYLLLPYDAKIGEKYIEESKKHNFEIIKSRAVFMDLYVGCKTVIIGLPSKIYEVISIVINNEEFSNALKERMREIINKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAK7</accession>
    <name>L0AAK7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate/tyrosine/aromatic aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232813.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1197"/>
    <dbReference type="EnsemblBacteria" id="AFZ70916">
        <property type="protein sequence ID" value="AFZ70916"/>
        <property type="gene ID" value="Calag_1197"/>
    </dbReference>
    <dbReference type="GeneID" id="14212457"/>
    <dbReference type="KEGG" id="clg:Calag_1197"/>
    <dbReference type="eggNOG" id="arCOG01130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_2"/>
    <dbReference type="OMA" id="APYWTTY"/>
    <dbReference type="OrthoDB" id="32104at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="391" mass="44595" checksum="F94AC61CD36E3919" modified="2013-03-06" version="1">MRTINNKIDLLKESPTRKIDAIREKLKRENKDIIVFSAGQPSIPPPIEIRELMGKLLKEESMNLYGYTPSQGILELREAISDDLKLLGGIDVNPSNIVITAGGQAAMFSTLATLLEPGDEVILFDPTYFGYKPLLDYNGAKIVRHYVTMEKDFQPNIDDIANIISKKTKAIILVSPDNPTGRIIDHKSAKGLAEIAIDNDIWIINDEAYKTLIYEGEHEFLYKYAPDNIISINTFSKDPSIPGWRLGYVYGPKNVIDKIKLVNEEMVYCPPSFAQHMVTRYLRSDIRLKYIKDVINEYRKRRDVMINAIKKRIPKAKYIIPKGSMFVFVDLKEYINDGEEFSANLLEKYQVASVPGNYFSEKYLSSLRLSFVAEKPERIEKGIEIISKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAQ0</accession>
    <name>L0AAQ0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamyl-tRNA(Gln) amidotransferase subunit E</fullName>
            <shortName evidence="6">Glu-ADT subunit E</shortName>
            <ecNumber evidence="6">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gatE</name>
        <name evidence="9" type="ordered locus">Calag_0318</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GatB/GatE family. GatE subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231993.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0318"/>
    <dbReference type="EnsemblBacteria" id="AFZ70095">
        <property type="protein sequence ID" value="AFZ70095"/>
        <property type="gene ID" value="Calag_0318"/>
    </dbReference>
    <dbReference type="GeneID" id="14211578"/>
    <dbReference type="KEGG" id="clg:Calag_0318"/>
    <dbReference type="eggNOG" id="arCOG01719">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030702_0_0_2"/>
    <dbReference type="OMA" id="SGFQRTM"/>
    <dbReference type="OrthoDB" id="35861at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00588">
        <property type="entry name" value="GatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004414">
        <property type="entry name" value="GatE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF2">
        <property type="entry name" value="PTHR11659:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00134">
        <property type="entry name" value="gatE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="8">
        <location>
            <begin position="489"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="640" mass="72279" checksum="FEE80DDE660176F6" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAR7</accession>
    <name>L0AAR7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232110.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0444"/>
    <dbReference type="EnsemblBacteria" id="AFZ70212">
        <property type="protein sequence ID" value="AFZ70212"/>
        <property type="gene ID" value="Calag_0444"/>
    </dbReference>
    <dbReference type="GeneID" id="14211704"/>
    <dbReference type="KEGG" id="clg:Calag_0444"/>
    <dbReference type="eggNOG" id="arCOG00498">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_932547_0_0_2"/>
    <dbReference type="OMA" id="VIRWIGA"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="16"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="298" mass="34433" checksum="B54973890371E278" modified="2013-03-06" version="1">MEIIRLESYNFPLDRPANNYLIKHDKYNILIDAGATKENLMAYESKIDYILITHGHWDHTYGITGIKNKKICASQDTYNSLINGEFKYSANRIAEIFGYNGKEFNINNEIKTIIDKTLSYYDDIANALKFNEYIPLDECDPIKQNIIEYIPCPGHSNDHVCYFISNNLFAGDNILPGGGLTLLDFLKYQESIIKLFTLNNWDLIRPGHGPDTKRIDIQQWIKDTLTGKEKKMMQLSSILNSDWVSINDLLPKLYPNLNGPLLYIAARSMIGYLGSLENMKIIEVDRNHKPWRARKLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-12-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAT3</accession>
    <name>L0AAT3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PKD domain protein,extracellular solute-binding protein, family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232023.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0348"/>
    <dbReference type="EnsemblBacteria" id="AFZ70125">
        <property type="protein sequence ID" value="AFZ70125"/>
        <property type="gene ID" value="Calag_0348"/>
    </dbReference>
    <dbReference type="GeneID" id="14211608"/>
    <dbReference type="KEGG" id="clg:Calag_0348"/>
    <dbReference type="eggNOG" id="arCOG01533">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319962_0_0_2"/>
    <dbReference type="OMA" id="FVNLGYE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="191"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="907" mass="100156" checksum="0D357F7F103961B8" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAU1</accession>
    <name>L0AAU1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease P protein component 2</fullName>
            <shortName evidence="2">RNase P component 2</shortName>
            <ecNumber evidence="2">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Pop5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rnp2</name>
        <name evidence="4" type="ordered locus">Calag_0476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0476"/>
    <dbReference type="EnsemblBacteria" id="AFZ70242">
        <property type="protein sequence ID" value="AFZ70242"/>
        <property type="gene ID" value="Calag_0476"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0476"/>
    <dbReference type="eggNOG" id="arCOG01365">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1763779_0_0_2"/>
    <dbReference type="OMA" id="RYIVFAI"/>
    <dbReference type="OrthoDB" id="102206at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00755">
        <property type="entry name" value="RNase_P_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="SSF160350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 2" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="147" mass="17277" checksum="376EC8967A9C38FC" modified="2013-03-06" version="1">MDLYLLYFIIVSILVSLLTTYLLNMYFIKKIENKFLLIPRKMKIKKPRRRYLIFEIASIKDIDPGLLENSIKEEFKNLFGITSLADSYLKLIYFDNKTKRGILRIKHIYLSHLITAIALIRKIDNDELLIIPIRTSGTINKAKKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAU3</accession>
    <name>L0AAU3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">50S ribosomal protein L37e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpl37e</name>
        <name evidence="12" type="ordered locus">Calag_0359</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10 11">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 11">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232033.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0359"/>
    <dbReference type="EnsemblBacteria" id="AFZ70135">
        <property type="protein sequence ID" value="AFZ70135"/>
        <property type="gene ID" value="Calag_0359"/>
    </dbReference>
    <dbReference type="GeneID" id="14211619"/>
    <dbReference type="KEGG" id="clg:Calag_0359"/>
    <dbReference type="eggNOG" id="arCOG04126">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208825_0_0_2"/>
    <dbReference type="OMA" id="RIRRYSW"/>
    <dbReference type="OrthoDB" id="124429at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_L37e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 10 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="62" mass="7058" checksum="8FFFD8E26446730A" modified="2013-03-06" version="1">MTKGTPSMGLHSKGKTHIVCRRCGRRAFNVSKGYCAACGFGKSKRIRKYSWQNKKVNRIRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAV7</accession>
    <name>L0AAV7_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl12</name>
        <name evidence="6" type="ordered locus">Calag_1303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232913.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1303"/>
    <dbReference type="EnsemblBacteria" id="AFZ71016">
        <property type="protein sequence ID" value="AFZ71016"/>
        <property type="gene ID" value="Calag_1303"/>
    </dbReference>
    <dbReference type="GeneID" id="14212563"/>
    <dbReference type="KEGG" id="clg:Calag_1303"/>
    <dbReference type="eggNOG" id="arCOG04287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_2_0_2"/>
    <dbReference type="OMA" id="EYIYAAM"/>
    <dbReference type="OrthoDB" id="131985at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_L12/P1/P2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="110" mass="11731" checksum="1BEF3FD1639D083A" modified="2013-03-06" version="1">MPQEGKAYVHAALALYYAGAQLNEDNLKKVVESLGLQADDAKVKMLVASLSELKLDEVLKSAAVAVSAPVSAPVSAPAEAEKKEEKKEEKKEEENKEVDVSEGLSGLFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAX0</accession>
    <name>L0AAX0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0400"/>
    <dbReference type="EnsemblBacteria" id="AFZ70170">
        <property type="protein sequence ID" value="AFZ70170"/>
        <property type="gene ID" value="Calag_0400"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0400"/>
    <dbReference type="eggNOG" id="arCOG01972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_1_2"/>
    <dbReference type="OMA" id="KEANPWI"/>
    <dbReference type="OrthoDB" id="126273at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="138" mass="15598" checksum="4A5A624583574418" modified="2013-03-06" version="1">MVNENAENLGKELSRLLMSKAEALENSLKEIVVEVKSDNFNEIINKNKLVFLFFTAEWCGPCISFLQTFREVASQHIVPNVFYGKVDVDSSYAIADKYKVKHIPSILIIVNGEVVDSIVGQTNKEKLENRISSYIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAX6</accession>
    <name>L0AAX6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232078.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0411"/>
    <dbReference type="EnsemblBacteria" id="AFZ70180">
        <property type="protein sequence ID" value="AFZ70180"/>
        <property type="gene ID" value="Calag_0411"/>
    </dbReference>
    <dbReference type="GeneID" id="14211671"/>
    <dbReference type="KEGG" id="clg:Calag_0411"/>
    <dbReference type="eggNOG" id="arCOG05511">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181971_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="95" mass="11346" checksum="7AD31A84871276F9" modified="2013-03-06" version="1">MIKYQKLIKFIENNPAYSYKEEGNIIEIIFNTPSIQEAAESDDVSETGRNMHIMLRRNKNDEIEVIDAEIEGLNYHKKMSKEEIEWWLNTIDMMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAY1</accession>
    <name>L0AAY1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoesterase, SbcD/Mre11-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232083.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0416"/>
    <dbReference type="EnsemblBacteria" id="AFZ70185">
        <property type="protein sequence ID" value="AFZ70185"/>
        <property type="gene ID" value="Calag_0416"/>
    </dbReference>
    <dbReference type="GeneID" id="14211676"/>
    <dbReference type="KEGG" id="clg:Calag_0416"/>
    <dbReference type="eggNOG" id="arCOG01150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075478_0_1_2"/>
    <dbReference type="OMA" id="GNHDTML"/>
    <dbReference type="OrthoDB" id="105276at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004376">
        <property type="entry name" value="CHP00024_Pesterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024173">
        <property type="entry name" value="Pesterase_MJ0037"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30337:SF5">
        <property type="entry name" value="PTHR30337:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000887">
        <property type="entry name" value="Pesterase_MJ0037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00024">
        <property type="entry name" value="SbcD_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="22"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="251" mass="28202" checksum="C7348D1C12633E58" modified="2013-03-06" version="1">MSFNEKLKILNRLPVLAYEKEKIAIISDIHLGYEEAMSSQGVYLPRLQLKKAKNIINEISKLNFKKLVIAGDLKHVFEKLIRQERAEILELMSFAAKSNIKEVILVKGNHDTYISNLLKDLGIQVEDNFLDLGDGIAVTHGHKIFDDIEKYQFIVMGHEHPSVEINLSGSKVRLQALLKMPLKNGSTALVLPPIGLYQTGTVVNLDKSSYLSPISRELGDIENTVPIIVDREIGVIELPRLIHIFGDNKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAY3</accession>
    <name>L0AAY3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Purine-cytosine permease-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232471.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0833"/>
    <dbReference type="EnsemblBacteria" id="AFZ70574">
        <property type="protein sequence ID" value="AFZ70574"/>
        <property type="gene ID" value="Calag_0833"/>
    </dbReference>
    <dbReference type="GeneID" id="14212093"/>
    <dbReference type="KEGG" id="clg:Calag_0833"/>
    <dbReference type="eggNOG" id="arCOG03447">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026016_3_0_2"/>
    <dbReference type="OMA" id="NTIYNFA"/>
    <dbReference type="OrthoDB" id="23625at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="439" mass="48664" checksum="1E8E555B61006C3C" modified="2013-03-06" version="1">MSIEWRGVERVEKESRHGKPISIFIIWLASNLTIADFALGSFLYGLPLPWIIFIVIFSNIIAGLIVGLLSSMGPKFGLPQMMISGTVYGKKINKVFSFAQWLSTLGWFSVNVIIGAQALVEIVKIPYYASLLINVVIMAIIGIYGIDMLHSFERAMSIILGALFLFLIIISLEKINGSIMLNYNKNVIFSPYLAAIVFAGVFSYMVSWAPYASDYTRYLPENTSMKKIILYATLGSAIAGIWTEVAGTVIYIASGNPSLNIMQATSQVIGKYLSVIALISIVLGGLSANALNLYSNSLSAQTLSYKFKRVYAALAGAIIGFLLAYIGSVIGFEMYYENFLLTLDYWIMPWAGILIASFFIRKRIRLDPIDNDYKPIISYIVALLISLPFMNLTSYGLSYEGIIAKMLGGADISYFVSFFVSMILYLILTIGNRKKSFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAZ2</accession>
    <name>L0AAZ2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the carbamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232943.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1337"/>
    <dbReference type="EnsemblBacteria" id="AFZ71046">
        <property type="protein sequence ID" value="AFZ71046"/>
        <property type="gene ID" value="Calag_1337"/>
    </dbReference>
    <dbReference type="GeneID" id="14212597"/>
    <dbReference type="KEGG" id="clg:Calag_1337"/>
    <dbReference type="eggNOG" id="arCOG00863">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076278_0_0_2"/>
    <dbReference type="OMA" id="QPMDVAG"/>
    <dbReference type="OrthoDB" id="77437at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00746">
        <property type="entry name" value="arcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="306" mass="33925" checksum="434549F05A34C9D6" modified="2013-03-06" version="1">MRLLIALGGNAILKKGDKGTVDEQWRNIKDAAEIISSIIKENDELILTHGNGPQVGYLLEVMQASNPEKALTIDIADAMTEGWIGYMLQNAFSLYLPDRKAVPVLTRTLVLENDEAFSHPTKFVGSYFTKDQAEILSKKYGWVFKEDPRGGFRRVVPSPMPVDIIEIDVIEKLIKDKYIVISVGGGGIPVIKKGNNYVPVEAVIDKDLASSLLATKIKADKFIILTDVKGVAINYGKKDEKWLDKISVDELKDLYKKNEFPEGSMGPKILAAIKFVESTGNKAIIGSLDNAREVYEEKSGTMIYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB19</accession>
    <name>L0AB19_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl2</name>
        <name evidence="7" type="ordered locus">Calag_0859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232496.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0859"/>
    <dbReference type="EnsemblBacteria" id="AFZ70599">
        <property type="protein sequence ID" value="AFZ70599"/>
        <property type="gene ID" value="Calag_0859"/>
    </dbReference>
    <dbReference type="GeneID" id="14212119"/>
    <dbReference type="KEGG" id="clg:Calag_0859"/>
    <dbReference type="eggNOG" id="arCOG04067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_0_1_2"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="OrthoDB" id="74812at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_A">
        <property type="entry name" value="Ribosomal_L2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_L2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="88"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="238" mass="25520" checksum="B59189ADDB9A3D22" modified="2013-03-06" version="1">MGKSLRQQRAGRGGSQFRNPGFIHVSPGKYLPNDGKTEKGIIKDLVHDPGRYVPLAYVITESGKEFFVPAAEGAYVGQEIQIGENAEPNFGNILPLNKIPEGTYVFNVELRPGDGGKLARQAGSYALVLGKSGDKVRIRLPSKVEKELDGNCRATIGIPAGAGRIEKPLLKASASYYKSKAKATKFPTVRGVAMNVASHPFGGGSHQHEGRPTTVARNTPPGRKVGHIAARRTGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB34</accession>
    <name>L0AB34_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232516.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0879"/>
    <dbReference type="EnsemblBacteria" id="AFZ70619">
        <property type="protein sequence ID" value="AFZ70619"/>
        <property type="gene ID" value="Calag_0879"/>
    </dbReference>
    <dbReference type="GeneID" id="14212139"/>
    <dbReference type="KEGG" id="clg:Calag_0879"/>
    <dbReference type="eggNOG" id="arCOG01749">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_2"/>
    <dbReference type="OMA" id="HDSMGEV"/>
    <dbReference type="OrthoDB" id="26165at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="20"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="448" mass="50081" checksum="09D9A110E3305D58" modified="2013-03-06" version="1">MSYEEEAEKYYLKTGLKVPNSLIKAISLIKASAALANKELNLLDKEIADAIVKVSLMISEGKFYDEVIVDVFQTGSGTGINMNINDIIARHASEILNKKVHPNDHVNMSQSSNDVIPSAIRIASYIEANDKVLPYLNNLIKKLEELSEKYKNIIKPGRTHLRDALPVTFGQELYAYYDEFYNDYNNLKYAMDQILYIPLGGTAVGTGINSHEKFKDIALKHLREFLNIDVKSSNSLMRTMRLLSDLLLLSSVYRKIAIDLWKIGNDLRLMFSGPNTAIGEIDMDISLAGSSIMPGKINPITVEAIMQASSEVIGLDNANSYISLLGEFELNMGNPSLIYNISLQSLLLKESLMKLSDVVLPSIKPLEDRMKQLALSSPSLITVFSPLIGYDNAKKLYERIRKGEKLEDVAKSLGLDQETINKITDLNILVKPGIPVLKVKKDDEKEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB44</accession>
    <name>L0AB44_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232265.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70367">
        <property type="protein sequence ID" value="AFZ70367"/>
        <property type="gene ID" value="Calag_0610"/>
    </dbReference>
    <dbReference type="GeneID" id="14211870"/>
    <dbReference type="KEGG" id="clg:Calag_0610"/>
    <dbReference type="eggNOG" id="arCOG02739">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2044290_0_0_2"/>
    <dbReference type="OMA" id="HKEVNPA"/>
    <dbReference type="OrthoDB" id="109129at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="123" mass="13993" checksum="D1B47B7E98CE2F7B" modified="2013-03-06" version="1">MEKICIPLSDDNKITITSRAKYLAIFEKLNDKPVVIEENPALNAKIKRPEFIKGCIKHKANVIIAAHGSYCSPSYNLIKENNIKAYVSENYSSIPPKFLKDLTMGEVLYSNMLAVYERLFSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB73</accession>
    <name>L0AB73_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232198.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0540"/>
    <dbReference type="EnsemblBacteria" id="AFZ70300">
        <property type="protein sequence ID" value="AFZ70300"/>
        <property type="gene ID" value="Calag_0540"/>
    </dbReference>
    <dbReference type="GeneID" id="14211800"/>
    <dbReference type="KEGG" id="clg:Calag_0540"/>
    <dbReference type="HOGENOM" id="CLU_1140528_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="243" mass="26933" checksum="80FC090D17BCD554" modified="2013-03-06" version="1">MSNLCKGIWLYVCIFYSISAFLFTLSILTMHEIMISSGIFLISLIEPIVFLKRRDYYIYATLSIISVLFVLISLKYLSLIILVLSLIYVTLKEFKAIVSSSLLIASMIIFMFQSLLIEKILFFVFLLLSTISIGFVTKRVHAFVIVIVALISLFTSPLVGLISSSVVAAIASFYFRQEEKVCPFTTDAGLAVGGGFIAGITIILSALYGWNLIVSSLLVLSVLLLLSGSMKPETVLTNKYENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABB4</accession>
    <name>L0ABB4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-ribbon RNA-binding protein with a function in translation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233048.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1446"/>
    <dbReference type="EnsemblBacteria" id="AFZ71151">
        <property type="protein sequence ID" value="AFZ71151"/>
        <property type="gene ID" value="Calag_1446"/>
    </dbReference>
    <dbReference type="GeneID" id="14212706"/>
    <dbReference type="KEGG" id="clg:Calag_1446"/>
    <dbReference type="eggNOG" id="arCOG01989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196471_1_0_2"/>
    <dbReference type="OMA" id="KCGFEGP"/>
    <dbReference type="OrthoDB" id="123853at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044720">
        <property type="entry name" value="HVO_2753-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011668">
        <property type="entry name" value="HVO_2753-like_ZBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40733">
        <property type="entry name" value="PTHR40733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07754">
        <property type="entry name" value="HVO_2753_ZBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HVO_2753_ZBP" evidence="1">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="69" mass="7679" checksum="5D438F527535D19A" modified="2013-03-06" version="1">MSVTAIKKLDMLDTVQPPICTSCGKIIHPREKAVAFYCPNCGKALIWRCSKCRKQGMQYKCPNCGFIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABD0</accession>
    <name>L0ABD0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L30e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl30e</name>
        <name evidence="7" type="ordered locus">Calag_1502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233100.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1502"/>
    <dbReference type="EnsemblBacteria" id="AFZ71203">
        <property type="protein sequence ID" value="AFZ71203"/>
        <property type="gene ID" value="Calag_1502"/>
    </dbReference>
    <dbReference type="GeneID" id="14212763"/>
    <dbReference type="KEGG" id="clg:Calag_1502"/>
    <dbReference type="eggNOG" id="arCOG01752">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130502_0_1_2"/>
    <dbReference type="OMA" id="RPHKIMA"/>
    <dbReference type="OrthoDB" id="117214at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_L30e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="L30/L30e/YlxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_L30e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_L30e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="PTHR11449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449:SF1">
        <property type="entry name" value="PTHR11449:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="6">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ71203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="102" mass="11182" checksum="C97572F0EFEE3095" modified="2013-03-06" version="1">MSVSLDKELKNLTKSGKYYLGVKKTIKSILRGEAKMVIIADNMPLVYRSKIEKNAKLSNIPLYVFKGTSMELGSLLGKPFKVSSISIIDTGESRILDLAGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABE6</accession>
    <name>L0ABE6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type Fe3+-hydroxamate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232641.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1022"/>
    <dbReference type="EnsemblBacteria" id="AFZ70744">
        <property type="protein sequence ID" value="AFZ70744"/>
        <property type="gene ID" value="Calag_1022"/>
    </dbReference>
    <dbReference type="GeneID" id="14212282"/>
    <dbReference type="KEGG" id="clg:Calag_1022"/>
    <dbReference type="eggNOG" id="arCOG04233">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_2_8_2"/>
    <dbReference type="OMA" id="GGYWWSA"/>
    <dbReference type="OrthoDB" id="90656at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="119"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="410" mass="45548" checksum="EB2E47AB5DB94F8E" modified="2013-03-06" version="1" precursor="true">MKSGNLIIALLIILIIGIGALGYSMMSLYNEMQKEINNLNSTILNLNNKTQITYNEKLSELANKIGSLENSINNFNSSVNTQILSLQQQINSLETQSQFPVTLIDATNTSVTITSYPERIVSLDPATTEILLSINATNQLVGVDNDSFYYLPPQYENELWKLYNEGKIINIGSTYSEPNIELILSAKPDLVIGTYQWSFSAVAQELKNYGIPTVLLPSYNSLSDLYNAIIMAGRSTGNIKNAVNLVESMSANISYFRYLINNISPQNVSYLLWINPTYVAGGNTFQNDMFILSGNNNVFSNISGWPIISPEELLQANPSIIIIDSNGGLINETTLISWLQSSIGNAYQNISAIKYNRVYTINGYYSDYLDEPGPMVIYGIKLLMMITHPSLFNLTTVPNNISPNTFPLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABF5</accession>
    <name>L0ABF5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable glycine dehydrogenase (decarboxylating) subunit 1</fullName>
            <ecNumber evidence="3">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Glycine cleavage system P-protein subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Glycine decarboxylase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Glycine dehydrogenase (aminomethyl-transferring) subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvPA</name>
        <name evidence="4" type="ordered locus">Calag_0722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GcvP family. N-terminal subunit subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0722"/>
    <dbReference type="EnsemblBacteria" id="AFZ70467">
        <property type="protein sequence ID" value="AFZ70467"/>
        <property type="gene ID" value="Calag_0722"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0722"/>
    <dbReference type="eggNOG" id="arCOG00077">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_0_2_2"/>
    <dbReference type="OMA" id="MYDGASA"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00712">
        <property type="entry name" value="GcvPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023010">
        <property type="entry name" value="GcvPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42806">
        <property type="entry name" value="PTHR42806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="464" mass="52152" checksum="232EC4ED0B42A250" modified="2013-03-06" version="1">MEHEWIPNSNEQIKKAMLDYIGVKDVLELYHDIPKQVLINEEKWDSLEIGKKRPLDQIEVEKIMDDVLNNNKIFDKSKLFIGGGAWPHYIPAAVQYLAERGEILTAYTPYQPEISQGLLQMLFEYQSLISDILEMEVVNASMYDMASALGEAFLMSKRINDKSKILIPETINPFHLSVAKSYTTPHEISLITYKVDPNTGYSDIEDIKNKLDDVSAIYLEYPYQYTGIVDINAKAISEIAHEKNALFIMGVNPLSLMLYKTPGELNADIAVGEGQPLGLGLNFGGPYLGIFATKWNAEYVKQMPGRLIGMTTSIDGSSKAFAMIMQTREQHIRRSKATSNITTNSSLSAITAAIYISLLGKKGLKDVAESIWYRSHYAAKKINSLGFKSPLFEGEFFGDFIVDFNTDFEKIRSKLIDYGILLGIPLNQYVTWAKSSWGLLSFTEVHSKSDIDFLLDKLESLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABF8</accession>
    <name>L0ABF8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232283.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0630"/>
    <dbReference type="EnsemblBacteria" id="AFZ70385">
        <property type="protein sequence ID" value="AFZ70385"/>
        <property type="gene ID" value="Calag_0630"/>
    </dbReference>
    <dbReference type="GeneID" id="14211890"/>
    <dbReference type="KEGG" id="clg:Calag_0630"/>
    <dbReference type="eggNOG" id="arCOG00040">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080904_0_0_2"/>
    <dbReference type="OMA" id="VVYPWNF"/>
    <dbReference type="OrthoDB" id="110748at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="228" mass="26926" checksum="9E6B621EBEDFB559" modified="2013-03-06" version="1">MPKVSVKLVSWSEIVDWAYNLSKLIESSNFNPDIIVAVARGGYVPARLLCDFLGVSDLLSVQSQHWIEAAKVTQKAILRYPYKIDAKNKNILVVDDIVDTGETLKLAKEYIAESWNPKDIRTASLQWISSVAKYKPDYYLIEVKDWSWYQYPWTRLEDIMEFIERIFKEDERAKKGLDYEELKSIFIEWYGISDKDLGEYWNLAFDKLISKKIIYKNGEKYYYELKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-02-10" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABH6</accession>
    <name>L0ABH6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1052"/>
    <dbReference type="EnsemblBacteria" id="AFZ70774">
        <property type="protein sequence ID" value="AFZ70774"/>
        <property type="gene ID" value="Calag_1052"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1052"/>
    <dbReference type="eggNOG" id="arCOG01096">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065373_1_0_2"/>
    <dbReference type="OMA" id="ADDEMRH"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01044">
        <property type="entry name" value="Ferritin_CCC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039376">
        <property type="entry name" value="Ferritin_CCC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Rubrerythrin" evidence="2">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="300" mass="33722" checksum="C334459B4460B2B6" modified="2013-03-06" version="1">MLCMLKDEDLKRAEKFCKDEINTYVLYKAISENSKDIQIKNHLLNLSKQELEHYNFWKEIVGHECKPDIKPGFVFKLLYRLFGPIFTLQIIEGNESSTIEDYEDFLNKLDDENQRKILQKIINDEQEHEKQIIYDIKDLRVKYLSYVALGLADAIVEVSGVHAGFLGATDKTLIAGIAGLVVGFSAALSMAGAAYLQAKQEKSVRASYGATVTGFTYLITVFVLALPYLLIRNIIDAFSISLILATAMISSFTYYSSVVHAQHFSKEIIESLLMLFLTAIAGFFFGDIIGKIFGIRALIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABI0</accession>
    <name>L0ABI0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate uptake regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233150.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1555"/>
    <dbReference type="EnsemblBacteria" id="AFZ71253">
        <property type="protein sequence ID" value="AFZ71253"/>
        <property type="gene ID" value="Calag_1555"/>
    </dbReference>
    <dbReference type="GeneID" id="14212817"/>
    <dbReference type="KEGG" id="clg:Calag_1555"/>
    <dbReference type="eggNOG" id="arCOG00318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069302_1_0_2"/>
    <dbReference type="OMA" id="SMHRDAT"/>
    <dbReference type="OrthoDB" id="38423at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="348" mass="39994" checksum="0C40F4DDB25F3CB2" modified="2013-03-06" version="1">MIRKNIKQTKLLRKVQITGGSTYIVSIPKEWAKELGIDKGLEIVMELGRDNSLRLYSPKREIKPVIMEKEIYVNQDLIDSAIVMEIISAYLAGYNSIKLVFSPLMLSRMDQIINEVRNKVVGLDVLEEGENNVTLRVVVDLSSIPEKLAMDNMQKTFKSMLEDFIEGIKNKDKEIFYSIIKRDDVMDKLYLYIYKQINLALQGQIKLEDIGINNSIEAINVYSTIKSIERIADHVVFMSSWIIDTLGEIEITEQLNKLINDVFNEVITVVNNIGKEININELIKSYSNLHELIIKELELIKSLKGSKQFFEIYPILDGLRRAMAYSLDIIEAQVGLSVIREIDEKRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABK6</accession>
    <name>L0ABK6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70512">
        <property type="protein sequence ID" value="AFZ70512"/>
        <property type="gene ID" value="Calag_0769"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0769"/>
    <dbReference type="HOGENOM" id="CLU_2327126_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="98" mass="11518" checksum="4E2AF3BBC092F451" modified="2013-03-06" version="1">MEVVSQKYVGSLFNGNVDLLNFLNQNVDLDVYVDRHAWSLLRGQLSKIGFSVEMTRKPKKMYIYISIEKGNVSLELRDHDKPIYKETISMEKFKEIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABL8</accession>
    <name>L0ABL8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane-associated protein/domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232716.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1097"/>
    <dbReference type="EnsemblBacteria" id="AFZ70819">
        <property type="protein sequence ID" value="AFZ70819"/>
        <property type="gene ID" value="Calag_1097"/>
    </dbReference>
    <dbReference type="GeneID" id="14212357"/>
    <dbReference type="KEGG" id="clg:Calag_1097"/>
    <dbReference type="eggNOG" id="arCOG00374">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_945269_0_0_2"/>
    <dbReference type="OMA" id="YKVGREN"/>
    <dbReference type="OrthoDB" id="107058at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="275" mass="31249" checksum="E9F0B94947E3EA54" modified="2013-03-06" version="1" precursor="true">MKNKKILLLVALILMLISIKITYSYNYIENNIYIDNAGDFISVSLINVTSPEAIIIPTIQPSSYIAYYINNYQTMPIDYNGTDLIVLANQTGILNITYISLGVVNKQGMIWSFNISESYYTKIFLPENSIPININPTPINVYYQSNSPVILMPPGKIFIQYTLSSQQLTLHKNNYSLYIIIIAAIVLIIASLIIFRKRKIGKKKKEKIKEEGIDERDKQIINAIKKLGGIATANQIMSETGIPKTPLYRRLSKLVEMGYIEEVVYGKTKSYKLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABM0</accession>
    <name>L0ABM0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin converting factor, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1563"/>
    <dbReference type="EnsemblBacteria" id="AFZ71261">
        <property type="protein sequence ID" value="AFZ71261"/>
        <property type="gene ID" value="Calag_1563"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1563"/>
    <dbReference type="eggNOG" id="arCOG00536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2645660_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="91" mass="10114" checksum="74ECB261E3CBD863" modified="2013-03-06" version="1">MYILKAIIIGDTMENKIKIKYLGYITDLSGKQYEEININGEETIENLLPFLKKLRDDDYIIVVNGKGAKLNNKVKGGDTIVILPQTGGGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABP7</accession>
    <name>L0ABP7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232746.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1127"/>
    <dbReference type="EnsemblBacteria" id="AFZ70849">
        <property type="protein sequence ID" value="AFZ70849"/>
        <property type="gene ID" value="Calag_1127"/>
    </dbReference>
    <dbReference type="GeneID" id="14212387"/>
    <dbReference type="KEGG" id="clg:Calag_1127"/>
    <dbReference type="eggNOG" id="arCOG03698">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1324070_0_0_2"/>
    <dbReference type="OMA" id="PKDETHR"/>
    <dbReference type="OrthoDB" id="66987at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019254">
        <property type="entry name" value="DUF2250"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10007">
        <property type="entry name" value="DUF2250"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="214" mass="25191" checksum="1732811864EC8CF3" modified="2013-03-06" version="1">MEEKGSEEKIIKETLQRIYEISPLDLYILFHLKKANVDYGRSIASILGISIDIITDELDKLEKMGLIERHQGSAIKRSEAKFKLAEEVRKHHTYYKLTRETCLSIRKLIKNYEGLNEYFKKITNYDNTLKLLIFLRKAENEHAGTIVKVFGLDMDKTINILEKLENLGLVIPVKEKIIKAKHRKAKPKEETRTHHIYYRITRLTEMILRYSEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABQ5</accession>
    <name>L0ABQ5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA-like transporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232756.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1137"/>
    <dbReference type="EnsemblBacteria" id="AFZ70859">
        <property type="protein sequence ID" value="AFZ70859"/>
        <property type="gene ID" value="Calag_1137"/>
    </dbReference>
    <dbReference type="GeneID" id="14212397"/>
    <dbReference type="KEGG" id="clg:Calag_1137"/>
    <dbReference type="eggNOG" id="arCOG00271">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_5_0_2"/>
    <dbReference type="OMA" id="TWGINNA"/>
    <dbReference type="OrthoDB" id="47457at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="156"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="295" mass="32932" checksum="41A77EC9F330F153" modified="2013-03-06" version="1">MNNIYKSLWKTKLGYTMNNNARGYIYLILVVLIWGSAYPVVKILENYISPIYVALLRSLIGGLIIFIIWRKMIFGIKETIAGILNNALFLIFLNLGIMYSKNPSLAAVLVYTQPIFVVILSKIYLKLKITLIQYIGIIIGFVGIFLTNISSIGFSIGLIFSLLSGISWALGTVYFVKNLHDRDIIGLNSYMSLISAPFISIFIPLSNYFIISLKSLLLILYTTAIIQAAAWLLWFYAVRALGPVKSSAIVMLTPAVSFIFTIYLIKVLPSLLQIIGSAIVLIGSIMSQSSYRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABR2</accession>
    <name>L0ABR2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232382.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0741"/>
    <dbReference type="EnsemblBacteria" id="AFZ70485">
        <property type="protein sequence ID" value="AFZ70485"/>
        <property type="gene ID" value="Calag_0741"/>
    </dbReference>
    <dbReference type="GeneID" id="14212001"/>
    <dbReference type="KEGG" id="clg:Calag_0741"/>
    <dbReference type="eggNOG" id="arCOG00497">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_3_0_2"/>
    <dbReference type="OMA" id="HFDHNAV"/>
    <dbReference type="OrthoDB" id="76909at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="217" mass="25221" checksum="2AA13A639925592F" modified="2013-03-06" version="1">MNIQWCGNSYFVIRHNDIEIAIDPHDGYSLNLKPCKINADYIIVTHNHFDHNAVEMAYGDKTKEVIRNYLGKKKVNGISFNFFEAFHDNANGKLYGKVIIFRLDIENINLGYLSDIGEKYNNSIKEKLYPTDVLMIPIGGVTTINYDEAIEYIDNLKPKIVIPMHYWIKGSAIPYDSINNFLNNVKYKVVEINENNIEIRNEDLPKETEIFVLNYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABR4</accession>
    <name>L0ABR4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S-cluster-containing hydrogenase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0831"/>
    <dbReference type="EnsemblBacteria" id="AFZ70572">
        <property type="protein sequence ID" value="AFZ70572"/>
        <property type="gene ID" value="Calag_0831"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0831"/>
    <dbReference type="eggNOG" id="arCOG01502">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_3_2_2"/>
    <dbReference type="OMA" id="RTCPTKA"/>
    <dbReference type="OrthoDB" id="105930at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12837">
        <property type="entry name" value="Fer4_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="170" mass="18790" checksum="A11FA29B7FA9ACC1" modified="2013-03-06" version="1">MVKMLMAIPDRCTGCGRCEEACSFQHFNIIDPSLSAIHVVRLENEPLDAPTFCIECGLCAMPGVCPENAIYRDPNTFAVLIDRNKCDGCTNCIVVCPYGVITLDHIEKKAVKCDLCGGDPQCVKACPENALAYIEANDAAYYKRYFFAELQKKGMVPIVPYPSPRTREAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABY4</accession>
    <name>L0ABY4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232841.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1227"/>
    <dbReference type="EnsemblBacteria" id="AFZ70944">
        <property type="protein sequence ID" value="AFZ70944"/>
        <property type="gene ID" value="Calag_1227"/>
    </dbReference>
    <dbReference type="GeneID" id="14212487"/>
    <dbReference type="KEGG" id="clg:Calag_1227"/>
    <dbReference type="eggNOG" id="arCOG00425">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_786668_0_0_2"/>
    <dbReference type="OMA" id="FVEVVKY"/>
    <dbReference type="OrthoDB" id="57874at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="352" mass="39156" checksum="23176BA844F5448D" modified="2013-03-06" version="1">MEESKETIAIIADWDADGVIAAAEIVYSQEKLGIFPVKGKKKVELIPSGPREIEHSLKNKCWDILIILDIPFSQEVSKALDDLYARGCKPKIYYFDHHPVTLENMSNIESKYNALAILGKSPTAILVRRFLDGLNIKLTPRLLNLIDAIGTLEGGGYLRNKQQVPEGIVKLAASISKALNQNKDKSIWAKYVEWASNPLPFEPSLLKGEEDFKDVIELGFEVSKESDKEIKEKAMELAMSAKNLGYIKFIDARDKWNKSGASALTSAIFKILKVTTALLTEKKEDNVRLLIIRSSKGEALKIMKNLFAMGITEDVGGHGNIAVAKIKPEITVRNLEEALRKASLQSFQEGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC35</accession>
    <name>L0AC35_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PKD domain protein,extracellular solute-binding protein, family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232584.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0964"/>
    <dbReference type="EnsemblBacteria" id="AFZ70687">
        <property type="protein sequence ID" value="AFZ70687"/>
        <property type="gene ID" value="Calag_0964"/>
    </dbReference>
    <dbReference type="GeneID" id="14212224"/>
    <dbReference type="KEGG" id="clg:Calag_0964"/>
    <dbReference type="eggNOG" id="arCOG01533">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319962_0_0_2"/>
    <dbReference type="OrthoDB" id="6658at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="201"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="916" mass="100916" checksum="C920A3B6020E7678" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC52</accession>
    <name>L0AC52_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">30S ribosomal protein S8e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps8e</name>
        <name evidence="7" type="ordered locus">Calag_0865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232502.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0865"/>
    <dbReference type="EnsemblBacteria" id="AFZ70605">
        <property type="protein sequence ID" value="AFZ70605"/>
        <property type="gene ID" value="Calag_0865"/>
    </dbReference>
    <dbReference type="GeneID" id="14212125"/>
    <dbReference type="KEGG" id="clg:Calag_0865"/>
    <dbReference type="eggNOG" id="arCOG04154">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080597_2_1_2"/>
    <dbReference type="OMA" id="NPNYVRR"/>
    <dbReference type="OrthoDB" id="116294at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00029">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020919">
        <property type="entry name" value="Ribosomal_protein_S8e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_S8e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_S8e/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018283">
        <property type="entry name" value="Ribosomal_S8e_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01193">
        <property type="entry name" value="RIBOSOMAL_S8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="127" mass="14112" checksum="8A7472792283AD37" modified="2013-03-06" version="1">MGVYQYRDIKKPSGGLRHLIHKRKRRYAMGEIFVPVVLQENDEKVIKRVMGGNAKVSLRKVSKAIVTDKNGKAKVTKILNVLSTPSNREYAKRNIITKGAIIQTSDGKARVTSRPGQDGIVNAVLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC79</accession>
    <name>L0AC79_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative redox protein, regulator of disulfide bond formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70737">
        <property type="protein sequence ID" value="AFZ70737"/>
        <property type="gene ID" value="Calag_1015"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1015"/>
    <dbReference type="eggNOG" id="arCOG02074">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2597506_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="1">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="79" mass="9314" checksum="FB2D230B017711B4" modified="2013-03-06" version="1">MIRMSNQQYDYRGKECPEGYILVTRLLSKLNPGETIEVIMDSWRCATMIAYEFAKVSSIEMKVDKLNQKDIKFVFKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACB6</accession>
    <name>L0ACB6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232674.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1055"/>
    <dbReference type="EnsemblBacteria" id="AFZ70777">
        <property type="protein sequence ID" value="AFZ70777"/>
        <property type="gene ID" value="Calag_1055"/>
    </dbReference>
    <dbReference type="GeneID" id="14212315"/>
    <dbReference type="KEGG" id="clg:Calag_1055"/>
    <dbReference type="eggNOG" id="arCOG13703">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_593980_0_0_2"/>
    <dbReference type="OrthoDB" id="142745at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="462" mass="51725" checksum="EA7293DE837B1881" modified="2013-03-06" version="1" precursor="true">MLKKYLLMIATFMLVASIIAFPLASMADYFQNNYTSNNYIIVYPNSISLLFNGSKYVDSEGYGSLNVNLLFLSGSKELTLNLSKYVDNNKYSLSEFKLYYNANGGMGISNYTSIHESQYFNSTSNGHLIVTANPSTKIYYINLSLYAVWEGSINYSNDIFNQLNNYQQFISQQFNMNDNFENNFNIQGVSNIFGFSSFNYSNIPGLNITYYNVKINKNSIYIEINATFNSSVITQNNANNESVLINNLINSYLKPKYLYISSYKIVENHTLKANLYINTNINLTSTSIPSYSNLNLNNIPQISQFNISIIKNALNASVEIIKYINNNYEILTPSSLSLNISYGNKIINYSLETPKIAFKTSTNAKENLLGIDYLIGNMSNILEQNGFDQLASKVNSAYMVKVTLIGKGVTVKPNQTTIGNLSNVSVVVNSNNSNMMTKEAIGGSVAVVLVILIAVILIKRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACC1</accession>
    <name>L0ACC1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232582.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0959"/>
    <dbReference type="EnsemblBacteria" id="AFZ70685">
        <property type="protein sequence ID" value="AFZ70685"/>
        <property type="gene ID" value="Calag_0959"/>
    </dbReference>
    <dbReference type="GeneID" id="14212219"/>
    <dbReference type="KEGG" id="clg:Calag_0959"/>
    <dbReference type="eggNOG" id="arCOG01411">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017896_3_0_2"/>
    <dbReference type="OMA" id="ENAFICS"/>
    <dbReference type="OrthoDB" id="32599at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="PTHR45919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="386" mass="44026" checksum="4AF3C32E499CEB34" modified="2013-03-06" version="1">MKEKIAIIHALFDEIGGGEKLALSAIDALVNGGYDVKVYTGTKVDQEKIKNILGYSLKNDDIIHIKSKLSIFLANITGNKAVRLRRLMIYRKLFNKEFLNKLRDNYDLIIDTQSNLPTPTDITYIHFPATIGTTNKRNFIEKLYDDIVSLASKGLTKTRPGRTLTNSKWTANKIYKEFGIIADILYPPVDLDYFSKVSYGSHNNKKIITISRFSPEKGLDKIVDIAKQLKEFDFYIVGATTPVLSDKVINTIKNKIKNENVKNVFLMPDLPRNELLKIMEESKIYLHPPFAEHFGISIVEAMASGLVPVVYKDGGGWYDIVSNIDKNLGYKEINEAANSIKYAYEKYDSLKQLSINISKKFSREEFKLNILKMVNYALEIKQLEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACF9</accession>
    <name>L0ACF9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoate--protein ligase</fullName>
            <ecNumber evidence="4">6.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_1013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232632.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1013"/>
    <dbReference type="EnsemblBacteria" id="AFZ70735">
        <property type="protein sequence ID" value="AFZ70735"/>
        <property type="gene ID" value="Calag_1013"/>
    </dbReference>
    <dbReference type="GeneID" id="14212273"/>
    <dbReference type="KEGG" id="clg:Calag_1013"/>
    <dbReference type="eggNOG" id="arCOG03837">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181210_0_0_2"/>
    <dbReference type="OMA" id="FVEVIIC"/>
    <dbReference type="OrthoDB" id="129723at2157"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016979">
        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019491">
        <property type="entry name" value="Lipoate_protein_ligase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10437">
        <property type="entry name" value="Lip_prot_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lip_prot_lig_C" evidence="8">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="90" mass="10097" checksum="C03A4E78E97E37DC" modified="2013-03-06" version="1">MGICELKAKKGLIRVSSQQDKGKIKSISITGDFMVFPEDVIWEMEKGLIGIDVDEKNIREMVKKYLSNAKLMGSSIDDFVEVIICSLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACI6</accession>
    <name>L0ACI6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232667.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1048"/>
    <dbReference type="EnsemblBacteria" id="AFZ70770">
        <property type="protein sequence ID" value="AFZ70770"/>
        <property type="gene ID" value="Calag_1048"/>
    </dbReference>
    <dbReference type="GeneID" id="14212308"/>
    <dbReference type="KEGG" id="clg:Calag_1048"/>
    <dbReference type="eggNOG" id="arCOG00335">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027059_3_0_2"/>
    <dbReference type="OMA" id="HCPVYDK"/>
    <dbReference type="OrthoDB" id="43344at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="399" mass="44276" checksum="4E3C94962CE0D397" modified="2013-03-06" version="1">MMDYLEKTILNISEILKDSDFREALESSVPMSEKRVLDFLNNHDDIVKLAKEVENIKNEVLSNIDYYIDMVFKSLKSINGNPYYANTKDDVLNIIDKIVGEKKRIILSKSMVAEEVGVREHLSALGKDVWETDLGQLLIQLENGKPMHAIAPAIHMTVKDVIKLVKDRLNIELRGDETPQQIVAKIRPFLREKFVNAQIGISGANAIAADSGSIFLIENEGNIRLVTTLPPVHIAIAGIEKIVPTLIDAFKVVLVQSSYAGLYPPTYVSMISGPSSTGDIGHRRVYGAHGPLELHLILLDNGRKDAIKNEFLKDQLRCVRCGNCQIFCPVWDITANKWGGKVYGGPMGVGWTAITEGIEKGAELSQLCLGCMRCDLACPVEIPLSSLIHNLKKIYVRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACM8</accession>
    <name>L0ACM8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps19e</name>
        <name evidence="5" type="ordered locus">Calag_1181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in maturation of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232799.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1181"/>
    <dbReference type="EnsemblBacteria" id="AFZ70902">
        <property type="protein sequence ID" value="AFZ70902"/>
        <property type="gene ID" value="Calag_1181"/>
    </dbReference>
    <dbReference type="GeneID" id="14212441"/>
    <dbReference type="KEGG" id="clg:Calag_1181"/>
    <dbReference type="eggNOG" id="arCOG01344">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108559_1_0_2"/>
    <dbReference type="OMA" id="YIDGPVG"/>
    <dbReference type="OrthoDB" id="92409at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01474">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_S19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027548">
        <property type="entry name" value="Ribosomal_S19e_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_S19e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="PTHR11710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="143" mass="15885" checksum="ED63A77576FBCB25" modified="2013-03-06" version="1">MVSAKEVPADKLIAKLAERLKKSQKIEPPSWAMYAKTGVFKEKPPVEQDWWYIRAASLLRKISLADEPLGVGTLRTMYGGKKRNGNRPPHFRKGSGSIIRTILQQLEQAGFIVTISGKGRKLSPSGQSLVDNVAKEILKEISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACN8</accession>
    <name>L0ACN8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1192"/>
    <dbReference type="EnsemblBacteria" id="AFZ70912">
        <property type="protein sequence ID" value="AFZ70912"/>
        <property type="gene ID" value="Calag_1192"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1192"/>
    <dbReference type="eggNOG" id="arCOG13729">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1745461_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="149" mass="16808" checksum="8AF047367791C9AA" modified="2013-03-06" version="1">MFRYVRSYYAIPYILLKIRITFSDNGVDSGRGVNLNTILVISSNIFGDGNSLKAAFKAADILRHEYSTTVFVEVVNSLNSLEVFNEMPKIRIGNNELVIEDNEDIDHIVNKIVDLVLENISVGSLNNVNDNIEIFSKNEPESYMGVFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACP1</accession>
    <name>L0ACP1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Glutamine synthetase</fullName>
            <ecNumber evidence="2 6">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="2 6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1103"/>
    <dbReference type="EnsemblBacteria" id="AFZ70825">
        <property type="protein sequence ID" value="AFZ70825"/>
        <property type="gene ID" value="Calag_1103"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1103"/>
    <dbReference type="eggNOG" id="arCOG01909">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_1_2_2"/>
    <dbReference type="OMA" id="VFPWESK"/>
    <dbReference type="OrthoDB" id="47310at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="7">
        <location>
            <begin position="91"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="3">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="451" mass="51082" checksum="3CDAB0FCF5569D1A" modified="2013-03-06" version="1">MGIAGIDFVDLQYIDLNGFLRSVTVPYKSYVEKVKGFVGAFDGSSVEGFQPINKSDMFLKADEKTYSVLPWNEKKARVLTEIYDFYGKRYQKDPRYIASLVTNYIKEQGFSPLVGTEIEFFLFSSVSIDIENPIRGLGYSLSSIEQPWDIDTLTLRTKKAYHHAEPNDKLAKTREDIINSFEKMGYGFEASHHEVAVSQNEVSVKAGDPLFVADEVITFKYVARNVAIQNNLIPVFMPKPLFGDNGSGLHFHLSLWDLDMKKNLFLDETSNELSQLARYFIGGILHHGRSLAALVAPTTNSYHRLVPGYEAPVYLVWGHSNRSAAIRIPATAGKKNLTRIEFRSPDPTCNPYLAISATLLAGLDGIKKKIDPGDPYELDVYEMPKEKLKGNIATLPKSLDEALEELESDNEYLQPVFSMELLNSYIEIKRNESDMIRMMPNPYEIYMYLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACQ4</accession>
    <name>L0ACQ4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232824.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1208"/>
    <dbReference type="EnsemblBacteria" id="AFZ70927">
        <property type="protein sequence ID" value="AFZ70927"/>
        <property type="gene ID" value="Calag_1208"/>
    </dbReference>
    <dbReference type="GeneID" id="14212468"/>
    <dbReference type="KEGG" id="clg:Calag_1208"/>
    <dbReference type="eggNOG" id="arCOG00002">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1598918_0_0_2"/>
    <dbReference type="OMA" id="NEASEVC"/>
    <dbReference type="OrthoDB" id="121662at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="159" mass="18280" checksum="48FBC5ED84DB6E7E" modified="2013-03-06" version="1">MKIQEENELQPKGAKAFRESLMWLVLRILAEKPSHGYEIMKKIEEMTHGRWKPAAGTLYPLLDSMQNEGLIEIKSYEQEGVRGGKKIIYGLTTNGWVLLKDQLINKISIYTSMINYIILGGIDCMRKEGYKNEASEVCNSLMEWLTKVQSELNVYCKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACT5</accession>
    <name>L0ACT5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233136.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1541"/>
    <dbReference type="EnsemblBacteria" id="AFZ71239">
        <property type="protein sequence ID" value="AFZ71239"/>
        <property type="gene ID" value="Calag_1541"/>
    </dbReference>
    <dbReference type="GeneID" id="14212803"/>
    <dbReference type="KEGG" id="clg:Calag_1541"/>
    <dbReference type="eggNOG" id="arCOG05463">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1559395_0_0_2"/>
    <dbReference type="OMA" id="SIAEIRF"/>
    <dbReference type="OrthoDB" id="138994at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="171" mass="19960" checksum="02E02A9A6029A8E1" modified="2013-03-06" version="1">MSDQTTEKAISKEELIEWLRKRIDELKDEMKMLETLLSYIEDSSRQNLNEKGEEVKLGRRRLGKIYRGESYVRLVPDIPIPLPQELKEYLETVEGELRTTQIKNGLQEQEQAKLVIKERPDASIAEIRFENLTTTIEILKAKAALKYTAEVAYQIYKAQNKNEGEEENKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACT7</accession>
    <name>L0ACT7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232854.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70957">
        <property type="protein sequence ID" value="AFZ70957"/>
        <property type="gene ID" value="Calag_1240"/>
    </dbReference>
    <dbReference type="GeneID" id="14212500"/>
    <dbReference type="KEGG" id="clg:Calag_1240"/>
    <dbReference type="HOGENOM" id="CLU_2550063_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="82" mass="8275" checksum="A5F44381AB900FF2" modified="2013-03-06" version="1">MLNSGSSPVTIDAIYVINASGVTLFGGTPNTPAPGPVTIGPNSIGAVSYTNTSKIPITPGTPITVEVVTTNGVQATYQTTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACX5</accession>
    <name>L0ACX5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative coiled-coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1185"/>
    <dbReference type="EnsemblBacteria" id="AFZ70905">
        <property type="protein sequence ID" value="AFZ70905"/>
        <property type="gene ID" value="Calag_1185"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1185"/>
    <dbReference type="eggNOG" id="arCOG01159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080079_0_0_2"/>
    <dbReference type="OMA" id="SEFRQEQ"/>
    <dbReference type="OrthoDB" id="129434at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="PTHR31027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="306" mass="36201" checksum="68615C5176004140" modified="2013-03-06" version="1">MVDSGQVQQNSQQQSNSESNEQNLLKHIDELRDKILEVKNQRRQLIEEIKSLRDKRRQLIEDKKQLIERFKVLRDQRKKILDELAKLKQERETLSKEFKSKLDQLKEAHNITQKEGDVAKLSLRKIQKRMEELEWRQQTSVLTPEEEKRLVEEIDKLEELAERVRRAREEEVSILELEADVKGLKLKLSEAINKIKELRENAGRLKAEISSINPKIDEYNKNIDSLGAEIQQKSQEIENLTKQLDALYQDYRNTMVKLKEMKLAKQRGIEVNLLEQKRKEIEEKQKKGEALTLDELRILYGDLDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACX9</accession>
    <name>L0ACX9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside-triphosphatase Calag_1190</fullName>
            <shortName evidence="3">NTPase</shortName>
            <ecNumber evidence="3">3.6.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Nucleoside triphosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the THEP1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.15" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232807.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1190"/>
    <dbReference type="EnsemblBacteria" id="AFZ70910">
        <property type="protein sequence ID" value="AFZ70910"/>
        <property type="gene ID" value="Calag_1190"/>
    </dbReference>
    <dbReference type="GeneID" id="14212450"/>
    <dbReference type="KEGG" id="clg:Calag_1190"/>
    <dbReference type="eggNOG" id="arCOG01034">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103145_1_1_2"/>
    <dbReference type="OMA" id="MELMIPG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00796">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004948">
        <property type="entry name" value="Nuc-triphosphatase_THEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146">
        <property type="entry name" value="PTHR43146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03266">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="188" mass="21554" checksum="2172B8FED80C26C0" modified="2013-03-06" version="1">MGINEKLNKSSISITGRPGVGKTTYALLLVEKLKSFQCKVKGFITKEIREGNTRIGFTVKDLSNDKQVVLASKNIKSTIRVGSYYLNEESFSFIIDILKNLNDSDVIVIDEIGPMELKINGFDNLLKNIIGKKPYIITFYYKLKEIRPDIYNLLNKGEIIELNFENRNKYMEKIDQYAKMIKDASLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD17</accession>
    <name>L0AD17_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232842.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1228"/>
    <dbReference type="EnsemblBacteria" id="AFZ70945">
        <property type="protein sequence ID" value="AFZ70945"/>
        <property type="gene ID" value="Calag_1228"/>
    </dbReference>
    <dbReference type="GeneID" id="14212488"/>
    <dbReference type="KEGG" id="clg:Calag_1228"/>
    <dbReference type="eggNOG" id="arCOG00134">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059688_0_0_2"/>
    <dbReference type="OMA" id="LASFPFW"/>
    <dbReference type="OrthoDB" id="107474at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="3"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="362" mass="39248" checksum="69EA3C05E3D2CC0E" modified="2013-03-06" version="1">MRQELSIYFSRIIYAAQWYILAPATLAIAESDKISQGLIGFLPFAFIIGAATTQIPAAYLSSKIGPKKTFLIGLFILSLSDIVVSFTNTFLEAFSLRILAGLGAGLYFSPAAAVLVSSNKERSATLMGLYNAAFSIGGLIGLSWGILDAILGWRIATFIGGLLGLIAFSENLFLVKDVKLITQSKLVFDKKLVILGIATSGIWGSSYAVGTLIPSFASELYKISPYKVSPLVSLYFLGNIIGGSITYLFEKRNKFRAIIFMSILTALTYPLYGIIGIYFMAIAALLNGIFINVATSIYYALAVDELNSINESLSLSIINLINMVIGVWVSPLFSFTMAINLKLSLYILLAVTIIPVVLIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD63</accession>
    <name>L0AD63_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="7">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">metG</name>
        <name evidence="11" type="ordered locus">Calag_1368</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="7"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232974.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1368"/>
    <dbReference type="EnsemblBacteria" id="AFZ71077">
        <property type="protein sequence ID" value="AFZ71077"/>
        <property type="gene ID" value="Calag_1368"/>
    </dbReference>
    <dbReference type="GeneID" id="14212628"/>
    <dbReference type="KEGG" id="clg:Calag_1368"/>
    <dbReference type="eggNOG" id="arCOG00810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_1_2_2"/>
    <dbReference type="OMA" id="SDMHGTP"/>
    <dbReference type="OrthoDB" id="6590at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="9">
        <location>
            <begin position="4"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="10">
        <location>
            <begin position="407"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="332"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ71077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="576" mass="67124" checksum="595871EC504B29DA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADE8</accession>
    <name>L0ADE8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232972.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1366"/>
    <dbReference type="EnsemblBacteria" id="AFZ71075">
        <property type="protein sequence ID" value="AFZ71075"/>
        <property type="gene ID" value="Calag_1366"/>
    </dbReference>
    <dbReference type="GeneID" id="14212626"/>
    <dbReference type="KEGG" id="clg:Calag_1366"/>
    <dbReference type="eggNOG" id="arCOG13714">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2490255_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="86" mass="9905" checksum="0039DD664196EDE6" modified="2013-03-06" version="1">MRITLSWEYCDICKRRNRTTLCKINNKEFIKVCPHCIALLSEIIECNGGQMKYPRAKTKEKGSKVVKKDLLDSIEREINGINSSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADK7</accession>
    <name>L0ADK7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233012.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1408"/>
    <dbReference type="EnsemblBacteria" id="AFZ71115">
        <property type="protein sequence ID" value="AFZ71115"/>
        <property type="gene ID" value="Calag_1408"/>
    </dbReference>
    <dbReference type="GeneID" id="14212668"/>
    <dbReference type="KEGG" id="clg:Calag_1408"/>
    <dbReference type="eggNOG" id="arCOG01357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032214_0_0_2"/>
    <dbReference type="OMA" id="GPAAWQW"/>
    <dbReference type="OrthoDB" id="5945at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="212"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="518" mass="58990" checksum="5C1DEB1AEB9625A7" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADM9</accession>
    <name>L0ADM9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:ubiquinone oxidoreductase subunit 6 (Chain J)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233037.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1433"/>
    <dbReference type="EnsemblBacteria" id="AFZ71140">
        <property type="protein sequence ID" value="AFZ71140"/>
        <property type="gene ID" value="Calag_1433"/>
    </dbReference>
    <dbReference type="GeneID" id="14212693"/>
    <dbReference type="KEGG" id="clg:Calag_1433"/>
    <dbReference type="eggNOG" id="arCOG04654">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136579_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="164" mass="17235" checksum="32319EA9708E3E78" modified="2013-03-06" version="1">MNPIDLLPIFALVLGVGSIISAYFVIKIKDLIYASSMLAVLASLIAALVALIGFGIVSAYLVLVYVGAAVMFIIIAISMVGVGRKESKEPFLGFVAGAAIAITIGIVILAGKFYNLYSYPEYVTVTQAASGLLSHYLPVIALIIIAQAATLVEAISIARRGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADQ6</accession>
    <name>L0ADQ6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233164.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1569"/>
    <dbReference type="EnsemblBacteria" id="AFZ71267">
        <property type="protein sequence ID" value="AFZ71267"/>
        <property type="gene ID" value="Calag_1569"/>
    </dbReference>
    <dbReference type="GeneID" id="14212831"/>
    <dbReference type="KEGG" id="clg:Calag_1569"/>
    <dbReference type="eggNOG" id="arCOG03849">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048388_0_0_2"/>
    <dbReference type="OMA" id="EPIWLDM"/>
    <dbReference type="OrthoDB" id="138075at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="470" mass="53056" checksum="FAAADC8D7EBE8C31" modified="2013-03-06" version="1">MSNVFKLLKFVIKTRVSNTMLAILIIVILYSIFTGLELMKSGVKIETKFPEYYAVAYATFFMTFSAFSGGLAVLKSDRDYLFMLPIKKSRLIFSLFIAQIIVLGTAVVAFIGFYLPFLGLNAWEAGVSYLLFILFITSISTYVGDLPTVRKALISVLLAIWGISPYFGFRYSPTAIFFGHAISGIDVLFPITILSMILTIRKLSNVSLEYQRSITREGNAEFKNTLKFDRYKGLRALYYLSINYITISGRSGGIGYGIRYFSNRIKLTTLLIIMTILSLIYFIISWKIFFAYLQITTIVVTMISISFFYSFTQSSIANERPWLSFTSMDPGKYLSHFSLSKTISTFIITIPLILANVGLYLIGGKYAITQIPTLVIAFPSFLIISFYIITRFNIIPQMKEEGVMPGQMRGRQMFFAIPIYILIFISIISSINLLSGIIASMILLIISVATLLNKKIWRNAALSLVENGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADR7</accession>
    <name>L0ADR7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator, contains C-terminal CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1483"/>
    <dbReference type="EnsemblBacteria" id="AFZ71185">
        <property type="protein sequence ID" value="AFZ71185"/>
        <property type="gene ID" value="Calag_1483"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1483"/>
    <dbReference type="eggNOG" id="arCOG00600">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076812_2_1_2"/>
    <dbReference type="OMA" id="VHRHHTI"/>
    <dbReference type="OrthoDB" id="67420at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="77"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="233"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="285" mass="31779" checksum="66C7FF010C976EAE" modified="2013-03-06" version="1">MAPRVSSYMRTPVYAVSPNDSLAHARNLMLKKEISRLVIVNDAEVPVGILTTTDIIDALFGKNYQKPLESILVGEVMTKDPIIIEESKSLKSASQIMLKHRIGGLPVVNSEKKLVGILTKTDIVKAFYDKYKGKYKVGDIMRKDYSTALPGHSIFYIARLIESDPTGKVIIIDESNKPIGVIAKKDIAYAQLPLSMLMSRGKDRFIRNKVPDVYKEKIISLRMYLVPIAEDIMSSNPFIIRPEDDAADAARIMIEENIGVLPVVDNNTLIGTLSKLEFMNIIAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADW7</accession>
    <name>L0ADW7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233142.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1547"/>
    <dbReference type="EnsemblBacteria" id="AFZ71245">
        <property type="protein sequence ID" value="AFZ71245"/>
        <property type="gene ID" value="Calag_1547"/>
    </dbReference>
    <dbReference type="GeneID" id="14212809"/>
    <dbReference type="KEGG" id="clg:Calag_1547"/>
    <dbReference type="eggNOG" id="arCOG12269">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1631549_0_0_2"/>
    <dbReference type="OMA" id="GNVMEEN"/>
    <dbReference type="OrthoDB" id="140185at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="162" mass="18934" checksum="B7AE3FBD21EF4EDA" modified="2013-03-06" version="1">MSIEVIGIEDLHNNLIQEANKEKNKYDYNMVKEEIKNIVNILKERNPEILNIEKEIIKVTLKNSKSFIIAYPPKYRIKAVETMKDIEMVWNILDRSSYNLLIFYSRKGTLTTSAYLYLGNVMEENEIGILFVNGDEKEINEVFDILEKTGSFIPEEESYVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7G5</accession>
    <name>L0A7G5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231711.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0017"/>
    <dbReference type="EnsemblBacteria" id="AFZ69813">
        <property type="protein sequence ID" value="AFZ69813"/>
        <property type="gene ID" value="Calag_0017"/>
    </dbReference>
    <dbReference type="GeneID" id="14211278"/>
    <dbReference type="KEGG" id="clg:Calag_0017"/>
    <dbReference type="eggNOG" id="arCOG02050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_5_2_2"/>
    <dbReference type="OMA" id="NLPMKVT"/>
    <dbReference type="OrthoDB" id="60370at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="285" mass="30795" checksum="66D75C8021E3FC67" modified="2013-03-06" version="1" precursor="true">MLELLYFALLALASIVSGFLGSLVGLGGGTFLVPIYTLYLGVPIIYATGASLISTIATSSGAGSAYVKDRITNVKLGMGLEVATSGGAIIGSLIATWVYQHHLASIIYIVFGIVLLIQIYFQLERSKFEIPKPMKPDRTTKFFKLYGEYHDYALKQDVKYYGVRWWLGEIIMFFAGMISGLLGIGSGALKVLGMDWAMNLPMKVSTTTSNFMIGVTAATGSSIYWVHGYIQPILAGITALGVLLGSFAGTKVLPGMKNKTIRYVFTAILAFLGVEMILRGLGIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7H6</accession>
    <name>L0A7H6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231721.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0030"/>
    <dbReference type="EnsemblBacteria" id="AFZ69823">
        <property type="protein sequence ID" value="AFZ69823"/>
        <property type="gene ID" value="Calag_0030"/>
    </dbReference>
    <dbReference type="GeneID" id="14211290"/>
    <dbReference type="KEGG" id="clg:Calag_0030"/>
    <dbReference type="eggNOG" id="arCOG02718">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149108_3_1_2"/>
    <dbReference type="OMA" id="SDRNMAI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002849">
        <property type="entry name" value="DUF131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01998">
        <property type="entry name" value="DUF131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="86" mass="9283" checksum="EA807EF17ED6B3FC" modified="2013-03-06" version="1">MPDIAIWLTIGIALIMIGFLVILIGTIYSSSKKDQTQKSEVGGVIMIGPIPIIFGNSWRAAKIAIILAIILITLAIVFMLIGRIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7J9</accession>
    <name>L0A7J9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Siroheme decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.111</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="ChEBI" id="CHEBI:140497"/>
            <dbReference type="EC" id="4.1.1.111"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Ahb/Nir family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.111" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231746.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0056"/>
    <dbReference type="EnsemblBacteria" id="AFZ69848">
        <property type="protein sequence ID" value="AFZ69848"/>
        <property type="gene ID" value="Calag_0056"/>
    </dbReference>
    <dbReference type="GeneID" id="14211316"/>
    <dbReference type="KEGG" id="clg:Calag_0056"/>
    <dbReference type="eggNOG" id="arCOG01628">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049427_1_0_2"/>
    <dbReference type="OMA" id="PGVSHNY"/>
    <dbReference type="OrthoDB" id="37761at2157"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040523">
        <property type="entry name" value="AsnC_trans_reg2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17805">
        <property type="entry name" value="AsnC_trans_reg2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg2" evidence="6">
        <location>
            <begin position="66"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="AsnC_trans_reg2" evidence="6">
        <location>
            <begin position="229"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ69848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="320" mass="36774" checksum="D51BC6283E754710" modified="2013-03-06" version="1">MDQIDKDILMELQYNFPLNSRPYDEIADKLGIKLNELLNRINNLKNEGIIKRIGFYYNFRSQGNEAALIAFESGENYKKLAEIAMKDPLVTHSYLRNHPIYNVWIVAKRSSHDELIKLAERMMKDSNSKSYVVLLSKRTYKLSVKFDLYNGISKAGRYALLPKNPPLLRDLGIDKDFPLSIKSLPINEKPYEYILKKYNMSEEELENSLKMLLDKGVLADPGAALDGEKLGFKENGMAVMEPDNNEESICECAASMSFSTHVVLRQSIPEGRWKHVSYAMIHATDKEKINKMVEELRKNCKPKDIMVIYSLEDLKPGVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7M0</accession>
    <name>L0A7M0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231766.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0078"/>
    <dbReference type="EnsemblBacteria" id="AFZ69868">
        <property type="protein sequence ID" value="AFZ69868"/>
        <property type="gene ID" value="Calag_0078"/>
    </dbReference>
    <dbReference type="GeneID" id="14211338"/>
    <dbReference type="KEGG" id="clg:Calag_0078"/>
    <dbReference type="eggNOG" id="arCOG04671">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014801_4_1_2"/>
    <dbReference type="OMA" id="CAPQVAG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="466" mass="52314" checksum="E365FDB9383FD057" modified="2013-03-06" version="1">MLCKNEISLDDFFKILFSNEKISICEERLNKIKRSREVYETEGKKGKVYGYSTSLGALLNKENAYTEEREKIILKEHDTGIGKNVPYLLVKAAMLVRLIQLSNGNSPIRQEVVNRLIDAINYDIIPTVSILGSVGASGDLAPLARIFRCIIYGEGSAYYKGKVVNCVDALKEKGLNVMNLIPGEALALINSNAFSTAFSIINAYITERLAYASLDIAKKSLKITGCNNEHFSDAVYETKKQMGVKKVIDMLNNSCEETPRLQDPYSIRCLPQIYGALFDTLEFSKSILKNEMNSSSDNPIIYENKVYHACQFHAIYSALISDFLKIAIIPVMNSIERRISQILDGKINRVNDFLLKENSVVGAMIMQYTSAALNAYSRGSSISMSSHSVPTSGTQEDIVSMAPNSSIELLKMNSLFLKIIAVELALYKYYNSKDLPDPRILLEESFSEIINNYNLKNFSEFLNYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7M4</accession>
    <name>L0A7M4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0145 protein Calag_0028</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231719.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0028"/>
    <dbReference type="EnsemblBacteria" id="AFZ69821">
        <property type="protein sequence ID" value="AFZ69821"/>
        <property type="gene ID" value="Calag_0028"/>
    </dbReference>
    <dbReference type="GeneID" id="14211288"/>
    <dbReference type="KEGG" id="clg:Calag_0028"/>
    <dbReference type="eggNOG" id="arCOG02287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117144_1_1_2"/>
    <dbReference type="OMA" id="VDFEISM"/>
    <dbReference type="OrthoDB" id="121009at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="122" mass="13151" checksum="D8EE1289BECA78E4" modified="2013-03-06" version="1">MSVSEKDVMVSTTPYIPGYKVTKVLGICLGITVRSRGLGGRILASLRSIAGGEIKEFTEMSEQSRVQAIERMITHAKGLGANAIISFRLDSNEVAETMDEIIAYGTAVVVEPDKSIAESKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7N6</accession>
    <name>L0A7N6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231781.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0095"/>
    <dbReference type="EnsemblBacteria" id="AFZ69883">
        <property type="protein sequence ID" value="AFZ69883"/>
        <property type="gene ID" value="Calag_0095"/>
    </dbReference>
    <dbReference type="GeneID" id="14211355"/>
    <dbReference type="KEGG" id="clg:Calag_0095"/>
    <dbReference type="eggNOG" id="arCOG02008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100105_0_0_2"/>
    <dbReference type="OMA" id="IGIYHEG"/>
    <dbReference type="OrthoDB" id="83812at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="198" mass="22542" checksum="D9F0FEEE9FA0E974" modified="2013-03-06" version="1" precursor="true">MNKRTIKKLIILFSILAILSSWVTIFTSISFNPWFKINKNAFSDLGGGSYINGHPPPMFPFIYNVGMIITGSLIFIFSIFIAFYSRNVIEAIGGSYFSLSGIFLILIGIYHEGTYPHIFVSLWFFILASISIFILGISLIKIYRNRGLFLTIFPILAWIFSYFIPFSSTAETELYGILAIEISVLLYISTLWIKLILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7V8</accession>
    <name>L0A7V8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isopropylmalate/homocitrate/citramalate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0173"/>
    <dbReference type="EnsemblBacteria" id="AFZ69958">
        <property type="protein sequence ID" value="AFZ69958"/>
        <property type="gene ID" value="Calag_0173"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0173"/>
    <dbReference type="eggNOG" id="arCOG02092">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_4_2_2"/>
    <dbReference type="OMA" id="CAVARCK"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="346" mass="39041" checksum="10B1DE356D016F48" modified="2013-03-06" version="1">MEIVDDTLREGLQSPGMSYKIEEKIKIAEMLGNAGIQNALVSYPSAHWSEKKVTEDIIKRKLIKNVYGLGRAFKNDIDQIYETGAHISLHFPFKYDNIDKVIEDIKYAIKLDDMTTVALVDVVSNKEIIINILRKLKEIGLKKVQLPDTTGNANPVFMRSLIKQAINEIGKDVEIEVHCHNDYGLSIANCLSAIEEGASSVSATVYGIGERNGISDLFTIYYALKKMGYNISLNEQALFELYDYMKELILKKIGVEFFIKNFPIVGENTNIMTAGTHAHFSSVFSQEKYSINVYVGRSMIKKILEKYKISLSDEKLSRLVELIKDVSVNEGKSLSYDDVLKLSKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7Z6</accession>
    <name>L0A7Z6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major Facilitator Superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231891.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0211"/>
    <dbReference type="EnsemblBacteria" id="AFZ69993">
        <property type="protein sequence ID" value="AFZ69993"/>
        <property type="gene ID" value="Calag_0211"/>
    </dbReference>
    <dbReference type="GeneID" id="14211471"/>
    <dbReference type="KEGG" id="clg:Calag_0211"/>
    <dbReference type="eggNOG" id="arCOG02793">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055959_0_0_2"/>
    <dbReference type="OrthoDB" id="38526at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="391" mass="44246" checksum="D0EACA415380ADAD" modified="2013-03-06" version="1" precursor="true">MKENQKKIREYTIISMSISILLYGFSITLGALLTQINSFPKYLDIYLLITPPLSLLLGNILFGRLADNYGRKPILVFTPILFSIGIVLFLIPNQYTTLLGVNLLLFSIAGGDEPAIISYSVENLSSNDRGKVMMLITNFVNIGALISSFIFIIFKYYLIMKITTSSFLFISLLISYILRKDLPESTLWIKSESKKIKDQNLTKISSLLFISISTILTYGLISWVIGPYYYPNLTSYIVLFFNLGNIIGGIIGYLIIDNIKRNSFVFFGFAGGIITSSFLLLAMHLHVNYSIFLPLLITNGIFTQLTWGSRLILEGELFSTKIRASSISLIRGSGWFIYIISTILTVNFTIILFQLYDILFWILGLLGSLIWYLYGIDTRKIPIEKLDKVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A869</accession>
    <name>L0A869_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231929.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0249"/>
    <dbReference type="EnsemblBacteria" id="AFZ70031">
        <property type="protein sequence ID" value="AFZ70031"/>
        <property type="gene ID" value="Calag_0249"/>
    </dbReference>
    <dbReference type="GeneID" id="14211509"/>
    <dbReference type="KEGG" id="clg:Calag_0249"/>
    <dbReference type="eggNOG" id="arCOG00961">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187361_0_0_2"/>
    <dbReference type="OMA" id="QFCGFCE"/>
    <dbReference type="OrthoDB" id="126329at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="109" mass="12455" checksum="DCBD17A95CDD46CE" modified="2013-03-06" version="1">MKVNIKLLYDEVSKCVYCGFCEAVCPTINLGTHRGYGPRGRVNLIKDVLENKIITEEFLASIYSCLLCDACYIVCPAKIDTGRIVRDMRSIIRSEYNSDKNEKIIIKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A879</accession>
    <name>L0A879_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein, putative amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231939.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0260"/>
    <dbReference type="EnsemblBacteria" id="AFZ70041">
        <property type="protein sequence ID" value="AFZ70041"/>
        <property type="gene ID" value="Calag_0260"/>
    </dbReference>
    <dbReference type="GeneID" id="14211520"/>
    <dbReference type="KEGG" id="clg:Calag_0260"/>
    <dbReference type="eggNOG" id="arCOG04536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_3_1_2"/>
    <dbReference type="OMA" id="PCFLWSG"/>
    <dbReference type="OrthoDB" id="35243at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="239" mass="26930" checksum="C9774132FEC9BDA5" modified="2013-03-06" version="1">MEYIWRVSGNKFDKLEKSIAIIPIGSLERHGDHLPLGTDTTEASYIAEEVAKKINAHLYPPIWYGSSIYLAKFPGTINVDSEAFKQYTFSVLKEIARNGYKLISIINGHGGNSSLLNIAAKEAAYSMNVTYIIIDWWKDVAQETRKKLFKEPGHAGDDETSAMLYIEGEDVDMKYAKDYVPSWIPKVSVQSPIIENYLYPNAVLGGATKGDKEKGRQWLESVIEEISKIIEDVYKLISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8A1</accession>
    <name>L0A8A1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major Facilitator Superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231964.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0286"/>
    <dbReference type="EnsemblBacteria" id="AFZ70066">
        <property type="protein sequence ID" value="AFZ70066"/>
        <property type="gene ID" value="Calag_0286"/>
    </dbReference>
    <dbReference type="GeneID" id="14211546"/>
    <dbReference type="KEGG" id="clg:Calag_0286"/>
    <dbReference type="eggNOG" id="arCOG03660">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_755663_0_0_2"/>
    <dbReference type="OMA" id="SHANVHI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="373" mass="42082" checksum="77E31B6B09232AFA" modified="2013-03-06" version="1" precursor="true">MRRNNIGFLFLSTSIVRFSSIIAQSVIPLYINSFIASSKLISIAIALLWISNGVGSLFSIYFKKIHNFLIISFSLTSLGFLFLVFNNNYFQIYISIILIGVGLGSISILLAPSMHQANNKFEGIGLYSFALSMGLILGTLFSSIILTYLSFKFIFISTILLLVSPLIFTLKNKYNPIDINIKFKINNLFSIIQNKKFLKYLTFNFIYSLILPLIISYWGIYETKTIGLKPNLVMISLFLLFILSSLIRFALIKINEKGLIKMEILAIAILPLIFIFLNTNNLILNITGLLLFSIPHSVLYPSFLYKAFNSLDKNNVVIGNMIFSTSSGAGEFLSPLIALTIITYFNISKLFLFTLPIPILLLIFYLLAYNSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8H8</accession>
    <name>L0A8H8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L44e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl44e</name>
        <name evidence="3" type="ordered locus">Calag_0397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232066.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0397"/>
    <dbReference type="EnsemblBacteria" id="AFZ70168">
        <property type="protein sequence ID" value="AFZ70168"/>
        <property type="gene ID" value="Calag_0397"/>
    </dbReference>
    <dbReference type="GeneID" id="14211657"/>
    <dbReference type="KEGG" id="clg:Calag_0397"/>
    <dbReference type="eggNOG" id="arCOG04109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114645_3_0_2"/>
    <dbReference type="OMA" id="CKKHTIH"/>
    <dbReference type="OrthoDB" id="106603at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01476">
        <property type="entry name" value="Ribosomal_L44e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_L44e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="PTHR10369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="95" mass="11231" checksum="B6E044814CA7F67D" modified="2013-03-06" version="1">MKFPKKIRTYCPKCNEHTEHSVALYKSGKRRTLSEGQRRYLRKNKGYGSKRKPEQKRFAKTTKKITLLITCSKCGYKRTILGIRLKKIELVEPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8K1</accession>
    <name>L0A8K1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lhr-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232054.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0382"/>
    <dbReference type="EnsemblBacteria" id="AFZ70156">
        <property type="protein sequence ID" value="AFZ70156"/>
        <property type="gene ID" value="Calag_0382"/>
    </dbReference>
    <dbReference type="GeneID" id="14211642"/>
    <dbReference type="KEGG" id="clg:Calag_0382"/>
    <dbReference type="eggNOG" id="arCOG00557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_0_0_2"/>
    <dbReference type="OMA" id="DWASKFR"/>
    <dbReference type="OrthoDB" id="6553at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="36"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="246"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="944" mass="107949" checksum="4BC011B273CB55AB" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8K6</accession>
    <name>L0A8K6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin converting factor, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232059.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0388"/>
    <dbReference type="EnsemblBacteria" id="AFZ70161">
        <property type="protein sequence ID" value="AFZ70161"/>
        <property type="gene ID" value="Calag_0388"/>
    </dbReference>
    <dbReference type="GeneID" id="14211648"/>
    <dbReference type="KEGG" id="clg:Calag_0388"/>
    <dbReference type="eggNOG" id="arCOG00534">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069141_0_0_2"/>
    <dbReference type="OMA" id="SEWKGHQ"/>
    <dbReference type="OrthoDB" id="62565at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="241" mass="27959" checksum="C04295C89FBA7E85" modified="2013-03-06" version="1">MRYIKLKLYSILKEIFNNNEITVEFKNDKITVEDILEYLNKNIKSPQFNQLFNSLRFIANNKILEKKDIIPKEVDVIHVLPPSSGGVIDVKVLTNEHVDLNDLIKNLYIDGNVGGVAIFIGVVRKVNKNEIVQKLQYEHSEELITNKLKEIAMKYINKYNLFSVVIYHYVGERKPGDLTMIVAVSGESRKNVFPALEEMVDDVKHNAPIWKQEYRESGRYFILGEDQVRAEDLKRISFSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-12-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8W0</accession>
    <name>L0A8W0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase-like amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0558"/>
    <dbReference type="EnsemblBacteria" id="AFZ70318">
        <property type="protein sequence ID" value="AFZ70318"/>
        <property type="gene ID" value="Calag_0558"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0558"/>
    <dbReference type="eggNOG" id="arCOG01943">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_8_3_2"/>
    <dbReference type="OMA" id="IVYTKIT"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="197" mass="22469" checksum="04BCACAF28352D57" modified="2013-03-06" version="1">MRYMSSYEDILKPSSSALIVWDVQNMLVQGIFNREEFMNSLNKLISSARSSNVPIFYTKITPLPDRFESPARKFILSRWGSRGSWGQDPSLYELAVKPEKNEIVINKNTASIFVGTNFELMVRNAGITTLVFTGIATEIGVESSARDAFNLGFYPIIAEDAVSSYDKEAHERSLANMRKMFIVMKSEDIINYWKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8X1</accession>
    <name>L0A8X1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lysA</name>
        <name evidence="6" type="ordered locus">Calag_0079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0079"/>
    <dbReference type="EnsemblBacteria" id="AFZ69869">
        <property type="protein sequence ID" value="AFZ69869"/>
        <property type="gene ID" value="Calag_0079"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0079"/>
    <dbReference type="eggNOG" id="arCOG02268">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_0_2"/>
    <dbReference type="OMA" id="YCRSMAS"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="52"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="281"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="274"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="418" mass="47400" checksum="CD8F787A2DF7F913" modified="2013-03-06" version="1">MGYNKNLILNDFFITGITLSIDKNLIMDLVKKFGTPLYITDVDIVKQNYENVYKSFKENFGKNFKIYYAMKANFNPFILETLKELGSGVDAASPYEFLLAKKVGFRDKEISFAPPNASREEIALASENGIGTLIFDSLDMINTAKGIHFDNYGIRINPGIEAGFNEKVMTGKAYSKFGIDISHIRDAIDKANEIKIEINGFHAHIGSNILDYEPYKLLMERFKELSKFLMKKNFIDMGGGFGYDYYNGKHYDISKISKAISENFPMEFNELRLEPGRYLVVNATVLLSKINGVKEMGNKKYIQIDAGMNSLIRPALYNAYHRVELINGDSNDEKEVFDVVGPICESDDYIALNVRLKRPKIGDYLIIHDVGAYGVSMASNYNLRPIPAEVILKNGKIIGIKERDDLDSIINKYKIYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8X3</accession>
    <name>L0A8X3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ordered locus">Calag_0546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0546"/>
    <dbReference type="EnsemblBacteria" id="AFZ70306">
        <property type="protein sequence ID" value="AFZ70306"/>
        <property type="gene ID" value="Calag_0546"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0546"/>
    <dbReference type="eggNOG" id="arCOG01711">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073198_1_0_2"/>
    <dbReference type="OMA" id="DEPTFPG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="177" mass="19940" checksum="C110EE17C2E6B20E" modified="2013-03-06" version="1">MCLDNLGPGSKAPDLVNMFVEIPMNSSVKYELDEETCLVKVDRFLYTSMSYPFNYGFIPGTKSEDGDPIDLLLISREPIMPGSIIEAKPIGMLIMQDEEGPDSKIIAVPKEKLDPIYGSWNNVNDIPDFLKKKISHFFEHYKELEPGKWVKVTGWEGADKAKAEILNAVKRAKEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Z2</accession>
    <name>L0A8Z2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">K+ transport system, NAD-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232256.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0601"/>
    <dbReference type="EnsemblBacteria" id="AFZ70358">
        <property type="protein sequence ID" value="AFZ70358"/>
        <property type="gene ID" value="Calag_0601"/>
    </dbReference>
    <dbReference type="GeneID" id="14211861"/>
    <dbReference type="KEGG" id="clg:Calag_0601"/>
    <dbReference type="eggNOG" id="arCOG01958">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01970">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_822869_0_0_2"/>
    <dbReference type="OMA" id="IRIRRFI"/>
    <dbReference type="OrthoDB" id="59460at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="123"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="3">
        <location>
            <begin position="263"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="345" mass="38399" checksum="99E6D59C773FB662" modified="2013-03-06" version="1">MRTKQKWLLDILEIIFAPYSIISRIVPQLIAIALVIIITSEVFIYYQHLDIISAIYASVGLITTIGLYAPAINQMPSLEKIFLTILVGSSVAIYTTLITGIIMTLSRRSVWIDARARWRAAHMKNHIVILGEMIEVAEELDRIKADYVMIVKNEEIAKKINSPRVIIGNPSSEIELKNSGVQEASVVLIALDNDLENMTALIRTKSLNPNARIITVIHDESLTDVFKQAGAYQVIRIRRFIGRALASLALSNNIGGILLESTEDSSRAVKKHGYAVGFFYVEKGSKCDGIKISEIPTKLLPILIQKQNNFTPYFTRDTKLDAGDGLVILGDPSEFHILKEMCTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0A918</accession>
    <name>L0A918_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nucleic-acid-binding protein containing a Zn-ribbon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231817.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0131"/>
    <dbReference type="EnsemblBacteria" id="AFZ69919">
        <property type="protein sequence ID" value="AFZ69919"/>
        <property type="gene ID" value="Calag_0131"/>
    </dbReference>
    <dbReference type="GeneID" id="14211391"/>
    <dbReference type="KEGG" id="clg:Calag_0131"/>
    <dbReference type="eggNOG" id="arCOG01287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119412_2_0_2"/>
    <dbReference type="OMA" id="DIECFEV"/>
    <dbReference type="OrthoDB" id="120594at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="82"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="176" mass="19904" checksum="5136F4A032A16F6B" modified="2013-03-06" version="1">MSTKINKLPGIKLKENEMYSLIGLVEDMPKAKYDFAAGTTISTFLHGLKEGKILGRKCPKCGRIYVPPRSYCEWCHVATNEWIEVPQTGEIHTAVITYISTKREKIEKPEVVGTIKLDVPGYREGEYEFAGLFHKICIDPQDVISGKAIGMKVKVKWKPKEERTGSILDIECFEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A961</accession>
    <name>L0A961_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0688"/>
    <dbReference type="EnsemblBacteria" id="AFZ70433">
        <property type="protein sequence ID" value="AFZ70433"/>
        <property type="gene ID" value="Calag_0688"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0688"/>
    <dbReference type="eggNOG" id="arCOG01420">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_18_5_2"/>
    <dbReference type="OMA" id="MPSRWEP"/>
    <dbReference type="OrthoDB" id="83551at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="4">
        <location>
            <begin position="14"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="317"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="530" mass="61022" checksum="EC308EC059090FCA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A973</accession>
    <name>L0A973_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl23</name>
        <name evidence="8" type="ordered locus">Calag_0672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Contacts protein L29.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0672"/>
    <dbReference type="EnsemblBacteria" id="AFZ70421">
        <property type="protein sequence ID" value="AFZ70421"/>
        <property type="gene ID" value="Calag_0672"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0672"/>
    <dbReference type="eggNOG" id="arCOG04072">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_4_2_2"/>
    <dbReference type="OMA" id="MDPYKVI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_L23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019985">
        <property type="entry name" value="Ribosomal_L23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03636">
        <property type="entry name" value="uL23_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="86" mass="9741" checksum="3EB135C76DC02917" modified="2013-03-06" version="1">MSEMEVILRIVMSEKASRLMEESNTLTFIVSRDANKQKIKEAIESLYNVKVESVNTLITPKGEKKAYVKLSKEYKAADIATKFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9A3</accession>
    <name>L0A9A3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase superfamily enzyme, subfamily IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232349.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0706"/>
    <dbReference type="EnsemblBacteria" id="AFZ70451">
        <property type="protein sequence ID" value="AFZ70451"/>
        <property type="gene ID" value="Calag_0706"/>
    </dbReference>
    <dbReference type="GeneID" id="14211966"/>
    <dbReference type="KEGG" id="clg:Calag_0706"/>
    <dbReference type="eggNOG" id="arCOG02293">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_3_2"/>
    <dbReference type="OMA" id="CAIELIN"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="221" mass="24411" checksum="91FB78D07A3E499D" modified="2013-03-06" version="1">MKGAIFDLDGTLASTAKAHKIAWELSLKQLGFNSNIDMEYLLGKRAMDIALLLIEQAGINDPDLKNKMAKKLLEVKNSIFAPYIMKYAEPMPCAIELINKLKQNNVKILVVTSSLRITAIKVLEKIKINPDVLISSDDVIKGKPDPEPTLAALKKSSLDANDILFAVGDTIYDIISFSKAGIKTIYLTKGDIIVPIDENLLKEYHAIKIDSLCDIIKISNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9D7</accession>
    <name>L0A9D7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232383.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0742"/>
    <dbReference type="EnsemblBacteria" id="AFZ70486">
        <property type="protein sequence ID" value="AFZ70486"/>
        <property type="gene ID" value="Calag_0742"/>
    </dbReference>
    <dbReference type="GeneID" id="14212002"/>
    <dbReference type="KEGG" id="clg:Calag_0742"/>
    <dbReference type="eggNOG" id="arCOG04150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064992_3_1_2"/>
    <dbReference type="OMA" id="DPLAVWK"/>
    <dbReference type="OrthoDB" id="80501at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019964">
        <property type="entry name" value="KH_domain_protein_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039912">
        <property type="entry name" value="PNO1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="PTHR12826:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03665">
        <property type="entry name" value="arCOG04150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="2">
        <location>
            <begin position="94"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="198" mass="22775" checksum="B6C9F6B5178733E7" modified="2013-03-06" version="1">MSGREGRIEKWVKIYSQIPSENKEIFLKHFNEIKNYIEERLKVKVEIDNNSSLITIEPLDNNTSPADMMKAKDIIQALSIGFVKEEALKLLDEENVLIVIDIKSKVGDSNNHIKRVMGRIIGEDGRAKRTIEEITGTSIHIGNNLIGVIGDYDRATIAQYGIELLIDGRMHSTVYKRLESMMREIKRHDLTNLWEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9E7</accession>
    <name>L0A9E7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major Facilitator Superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0263"/>
    <dbReference type="EnsemblBacteria" id="AFZ70044">
        <property type="protein sequence ID" value="AFZ70044"/>
        <property type="gene ID" value="Calag_0263"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0263"/>
    <dbReference type="eggNOG" id="arCOG02792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055959_0_0_2"/>
    <dbReference type="OMA" id="FSEWAWA"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="442" mass="49267" checksum="C738C4B6984B9BE5" modified="2013-03-06" version="1">MKILSDIIKIVDKMGWNRTLTLAFLSLGIGFFMWGVITTLGILTYPEYHNVYYLVYVSSIPLIGDLLLSRLSDISLGRKTTFFITMFLYSLGSIIFILNSAFWGSNIYVTLAAYTIAIIGVEGEVPVALSLIAELFPLKYREKMLVILPNFDNIGAVIASLIAFLTYYVSSSFAIEGISMGIVALVGALIAIIVRFSLPESIRWLVVKGKTNKAKDELNKIKGGLNIQEEPINLNITKNTSLGFRYSFLAIIGISQYLTYGLMAYVIADYYFTGLSLDLVVLFANVGASIGGVVAMMLVDKLGTRKFATISYLGGFLTMIPVLIYVALFKNYIVMFYPLLFLNMIFSEFGWAVRTVYEPTLMPTRSRAFLVGLIRAPIMLIYTISVYLTASFTELEFVIYNMILWGIGALAAGAWHIFGYDINRVPLEKTSGEEKISQKIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9E9</accession>
    <name>L0A9E9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily, subfamily-IB PSPase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232420.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0781"/>
    <dbReference type="EnsemblBacteria" id="AFZ70523">
        <property type="protein sequence ID" value="AFZ70523"/>
        <property type="gene ID" value="Calag_0781"/>
    </dbReference>
    <dbReference type="GeneID" id="14212041"/>
    <dbReference type="KEGG" id="clg:Calag_0781"/>
    <dbReference type="eggNOG" id="arCOG01158">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036368_4_5_2"/>
    <dbReference type="OMA" id="AINPHEG"/>
    <dbReference type="OrthoDB" id="105892at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006386">
        <property type="entry name" value="HAD-SF_hydro_IB_PSP-like_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01491">
        <property type="entry name" value="HAD-SF-IB-PSPlk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="218" mass="24988" checksum="59C87948600A2237" modified="2013-03-06" version="1">MGKIKLVVFDVDGVLTKEKSSWGFVHKHFNVEDKAKIYFEKFEKGEINYVDWMKLDTSLWIEKNNGKLKRETLIEILNKIEVRPEAQEVSMCLHKKRKLIALISGGIDLLVSRISKVIGADFWFANELEFDKFGYLIPGGYPLVGVNKEKPLKMLLLSENIKPDEAAYVGDSTWDASAMKLVKYPIQFGDDESLSNIAKFKINNLKEICNIINEIEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9G2</accession>
    <name>L0A9G2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231957.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0279"/>
    <dbReference type="EnsemblBacteria" id="AFZ70059">
        <property type="protein sequence ID" value="AFZ70059"/>
        <property type="gene ID" value="Calag_0279"/>
    </dbReference>
    <dbReference type="GeneID" id="14211539"/>
    <dbReference type="KEGG" id="clg:Calag_0279"/>
    <dbReference type="eggNOG" id="arCOG01726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_2"/>
    <dbReference type="OMA" id="CEGQALD"/>
    <dbReference type="OrthoDB" id="55053at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="338" mass="37917" checksum="B330AB59823E0A4C" modified="2013-03-06" version="1">MSYETLNKISEKYLLLIDSYISDILKGEPELLYKAAMHLIKAGGKRLRPMITLASSKALGGATSEAKAVYYASAVEILHNFSLVHDDIMDNDDFRRGIPTVHKVYGINWALLAGDLMFSYAFLTPYLAIKSGANEKEVSRAVEVIAEGSKKIAEGQGYDILFEKTWDVDEKDYLKMIYLKTGALIEASSKLGGIASNSNDEIIELLGEYGRFTGLAFQIKDDILGVFGDPEKTGKPVYNDLRRGKKTILVLYATSRKKEWKEFFMKLFTGNQSDEEIKEAADIIKESGSLKYAEELAKNYYNNALEKLNSIETLGIIKDEESFKALKELAEFSINRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9P3</accession>
    <name>L0A9P3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable urocanate hydratase</fullName>
            <shortName evidence="7">Urocanase</shortName>
            <ecNumber evidence="7">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hutU</name>
        <name evidence="11" type="ordered locus">Calag_0077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="7">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="7"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0077"/>
    <dbReference type="EnsemblBacteria" id="AFZ69867">
        <property type="protein sequence ID" value="AFZ69867"/>
        <property type="gene ID" value="Calag_0077"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0077"/>
    <dbReference type="eggNOG" id="arCOG04670">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018868_0_1_2"/>
    <dbReference type="OMA" id="LVGDWAN"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="9">
        <location>
            <begin position="43"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="8">
        <location>
            <begin position="166"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="10">
        <location>
            <begin position="376"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="298"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ69867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="580" mass="65143" checksum="C9854C8F106BF611" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9P9</accession>
    <name>L0A9P9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0082"/>
    <dbReference type="EnsemblBacteria" id="AFZ69872">
        <property type="protein sequence ID" value="AFZ69872"/>
        <property type="gene ID" value="Calag_0082"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0082"/>
    <dbReference type="eggNOG" id="arCOG01573">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115707_0_0_2"/>
    <dbReference type="OMA" id="FGWQIVK"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ69872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="209" mass="21958" checksum="1FA4D358E17AFF2E" modified="2013-03-06" version="1">MSSTSTSTNTKGRTVGAGRAIALTIVYIVIYVIVSAITKYIIESLLPSFHIFAVKYEVYVQILLALAFGYLIVNGFSSIFYYSLLSKYGHPTAAAIRNVVRIIGIGALAASIAGAVAGGAAGVALGGFIGIVIGFATQQVLGQAVSGLFLLIARPFKINDNVNIVGEDGIVEDVATLFTTVVKADGTKVLVPNNLIIGNKIYLKQQQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Q5</accession>
    <name>L0A9Q5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0878"/>
    <dbReference type="EnsemblBacteria" id="AFZ70618">
        <property type="protein sequence ID" value="AFZ70618"/>
        <property type="gene ID" value="Calag_0878"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0878"/>
    <dbReference type="eggNOG" id="arCOG01191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1922669_0_0_2"/>
    <dbReference type="OMA" id="YGISCYE"/>
    <dbReference type="OrthoDB" id="111480at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="131" mass="15306" checksum="FC1360A794D3145F" modified="2013-03-06" version="1">MMKKNTNEIIRLLKSANYHLNNGDYGISCYESRLSAIYSMEILANYLNIEINGSNLREIYKQINKIVNLSSIRYCIDYLDSLKNLEVNYCDTYCSDEIPGAEVLDYVNYDDSFRAYKCSNEIKDFVFRIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Q6</accession>
    <name>L0A9Q6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemA</name>
        <name evidence="12" type="ordered locus">Calag_0369</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232042.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0369"/>
    <dbReference type="EnsemblBacteria" id="AFZ70144">
        <property type="protein sequence ID" value="AFZ70144"/>
        <property type="gene ID" value="Calag_0369"/>
    </dbReference>
    <dbReference type="GeneID" id="14211629"/>
    <dbReference type="KEGG" id="clg:Calag_0369"/>
    <dbReference type="eggNOG" id="arCOG01036">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035113_0_0_2"/>
    <dbReference type="OMA" id="CELKAME"/>
    <dbReference type="OrthoDB" id="48038at2157"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="11">
        <location>
            <begin position="22"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="10">
        <location>
            <begin position="165"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="9">
        <location>
            <begin position="301"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="52"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="183"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="397" mass="45716" checksum="0906E4C606AFF1DD" modified="2013-03-06" version="1">MIDQTYNINNLKLYSITYKDSCFYDMEKIDELKERIYDDIFHISNGIIILSTCNRFEIYVDSYNDILEEEINKNMGIYSKFFHKYSGLESAEHLFRVSAGLESSILGETEILSQVKDAWEEAKNLGYTSKLLDSVFHQSIIVGKRVRSETDISKGVLGFPQASVELASKLLGTLDNKEIAIIGAGNAAKIMVDHICSKWNPSKITIANRTLEKAKMIINNKCNFEINTLNEIANKKFDAVLIAIKGGPFDFLNNLLNKNDVIIDISTPSAIMNDNTIYNIESVDKLVKENFNHRLDQVQLAEKIIKEELDKLIEYLKKRSIDENISEIMRYIDLIIKYEMEQTKKNINKGMDLDEALKIAFESFAKKSMKPIFNLLHDTYNENISELIIQYYKKNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Q7</accession>
    <name>L0A9Q7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232488.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0850"/>
    <dbReference type="EnsemblBacteria" id="AFZ70591">
        <property type="protein sequence ID" value="AFZ70591"/>
        <property type="gene ID" value="Calag_0850"/>
    </dbReference>
    <dbReference type="GeneID" id="14212110"/>
    <dbReference type="KEGG" id="clg:Calag_0850"/>
    <dbReference type="eggNOG" id="arCOG01617">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_2"/>
    <dbReference type="OMA" id="RAWNDRS"/>
    <dbReference type="OrthoDB" id="43721at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="319" mass="37629" checksum="10D643D8E91E79A5" modified="2013-03-06" version="1">MKYRKLKSINKEVSEIGIGLWSLVSYEWGGVVNNEEILTYAYEKGINFFDTADIYGKGEGERLLGNVFKNNREEIVILTKIGYDLKTNRRRFDLNYLKDAIDNSLNRLNTSYIDILMLHNPTMEIIKNNEIFEFMNDLKEEGKILSYGISLGPTLGWEEEGYKSIEMGYHSLEHIYNIIERYPGEKFLRFNNIDHFIRVPHASDVLNDMKWPLKFDSKLHRKFKDMKWIEEALKGAEILQKKINRFKLHEIAILYVLSNKNVSSVLPNITSKDEIDIYSRIIDNNMELNENELQTIDDVYNTYFKKLNEESIDETKMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9U3</accession>
    <name>L0A9U3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoglucosamine mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_0032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231723.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0032"/>
    <dbReference type="EnsemblBacteria" id="AFZ69825">
        <property type="protein sequence ID" value="AFZ69825"/>
        <property type="gene ID" value="Calag_0032"/>
    </dbReference>
    <dbReference type="GeneID" id="14211292"/>
    <dbReference type="KEGG" id="clg:Calag_0032"/>
    <dbReference type="eggNOG" id="arCOG00767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_2"/>
    <dbReference type="OMA" id="PHNPEPL"/>
    <dbReference type="OrthoDB" id="58941at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03087">
        <property type="entry name" value="PGM_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="154"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="259"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="377"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ69825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="456" mass="50800" checksum="9F59508E18AEC586" modified="2013-03-06" version="1">MARLFGTDGVRGIVGELITPEFSLRMGHAIGAYFGKGSRLLIGRDVRLGGDMVVRSLTAGLLAEGIKVYDAGLLPTPALQYGIKSLGFDGGVMITASHNPPEYNGIKVISSDGIEIPHENEDIIENYYFNNYLSKMEWRSYDNFVKSRDDIIDIYIDAIINQVDVEKIAKKNFKVVVDCANSVGSLTSPLLLRKLGVKAFTVNCNLDPYFPGRNPEPNAETLQNTLNYIKLIKADAGFAHDGDADRAMVLDNEGRIQWGDRTGALLTEFSSKIWKNYNKKTYTAVSSSILVEEYLKPKGIDVAWTPVGSVTIAREITKNNDAISGFEDNGGYLHVPHHVVRDGAMTIALTLYMLSETNETLNNIYNKLPQYYAIKAKIEANREQALCGVEAVKEKYSSYRMITIDGVKVFGDDFWLLVRPSGTEPILRITGEAKDKEKIEKIINDTIKYVKERCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9U9</accession>
    <name>L0A9U9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232565.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0937"/>
    <dbReference type="EnsemblBacteria" id="AFZ70668">
        <property type="protein sequence ID" value="AFZ70668"/>
        <property type="gene ID" value="Calag_0937"/>
    </dbReference>
    <dbReference type="GeneID" id="14212197"/>
    <dbReference type="KEGG" id="clg:Calag_0937"/>
    <dbReference type="eggNOG" id="arCOG00922">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="LPWLTCF"/>
    <dbReference type="OrthoDB" id="112777at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="217" mass="24535" checksum="3D0978ED48181C94" modified="2013-03-06" version="1">MIKLIEIKVSKNKKEIIKRANLTLNKGEIVEIYGKNGSGKTTLLKVLSLIQKVDEGNVIYFNKNITNYKESNLSKIRLNYIGYVEQQYRLIPGLNVLESISLPLLLKGINKKEAEKISIELINEMNLKGKEGEVVDNLSGGEKQRVSIASAIAKDPKVLILDEPFSNQDDIGEEIIIKKLKELKIKEKIIVFSSPYMIEGIADKIYIMKEGILMEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9W0</accession>
    <name>L0A9W0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PKD domain protein,extracellular solute-binding protein, family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231825.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0140"/>
    <dbReference type="EnsemblBacteria" id="AFZ69927">
        <property type="protein sequence ID" value="AFZ69927"/>
        <property type="gene ID" value="Calag_0140"/>
    </dbReference>
    <dbReference type="GeneID" id="14211400"/>
    <dbReference type="KEGG" id="clg:Calag_0140"/>
    <dbReference type="eggNOG" id="arCOG01533">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319962_0_0_2"/>
    <dbReference type="OrthoDB" id="6658at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="193"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="917" mass="101487" checksum="FC23FCEE71F17079" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA03</accession>
    <name>L0AA03_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase, diketogulonate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232625.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1006"/>
    <dbReference type="EnsemblBacteria" id="AFZ70728">
        <property type="protein sequence ID" value="AFZ70728"/>
        <property type="gene ID" value="Calag_1006"/>
    </dbReference>
    <dbReference type="GeneID" id="14212266"/>
    <dbReference type="KEGG" id="clg:Calag_1006"/>
    <dbReference type="eggNOG" id="arCOG01619">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_2"/>
    <dbReference type="OMA" id="YQVHWPF"/>
    <dbReference type="OrthoDB" id="35652at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="10"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="204"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="263" mass="30215" checksum="402D00F9DB28EEEF" modified="2013-03-06" version="1">MKLCDKEVGKIGFGTWGIGGGYWQKDYSKDKESIEILRYAYEKGFRLFDTAEMYGDGHSEELVGKALNEYEDVLIVSKVWSNHLRHDDLIKSAINSRKRLGIKSIDLYLIHWPNNRVPIEESIRAMEELIDSGVIRCMGVSNFDVKLLKDAMQSAKKYEIAVNEIEYNVFHKSPENDIIPFAKENKIEIIAYSPLAKGEVIYDSILKKIGEKYNKTSVQIALNYLLKNSIPIPKASNKKHIDEIMGSIDFQINEEDYEILKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA09</accession>
    <name>L0AA09_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0493"/>
    <dbReference type="EnsemblBacteria" id="AFZ70259">
        <property type="protein sequence ID" value="AFZ70259"/>
        <property type="gene ID" value="Calag_0493"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0493"/>
    <dbReference type="eggNOG" id="arCOG04310">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_2"/>
    <dbReference type="OMA" id="GFPHDFH"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="126"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="244"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="413" mass="45887" checksum="1588FD0AE1CD3EBD" modified="2013-03-06" version="1">MINLDFDLSQDEKLFKESIHEFLSKELSPIWIKMDSERKIPTEVIHKMGEQGLFAIAVPEEYGGQGGNFLLAALAVEEVAYNDPAVATAVFTLLNNSWPYILYLYGKEEAKQEILPIVGKGRGFFGIASTETIGGSDVAGERTTAKKEGNLYKINGEKIYISGVREALEQLDLGSWFLIARTGRQEDKHRGLSTFAFIGNKNGKITEGLEYSILNTIGRHAISTGLLHFKDATIDSNHLIGEENKGFYLAMQGFSIARVLVSAANIGAAQWALEQAVKYSRERRMFDDKPIASFQGVSFPIAEVAAKIEATRLLIYKSAQLADKIFIKKESGYKPQDLNYWASASKIMAIETAFQAIETTMKTYGGYSYTEEANVFRNLLGVLSYLVGAEGSQNIMRYIVARELIGREYVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA11</accession>
    <name>L0AA11_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1016"/>
    <dbReference type="EnsemblBacteria" id="AFZ70738">
        <property type="protein sequence ID" value="AFZ70738"/>
        <property type="gene ID" value="Calag_1016"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1016"/>
    <dbReference type="eggNOG" id="arCOG13732">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2079301_0_0_2"/>
    <dbReference type="OMA" id="CERGTIG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="117" mass="13819" checksum="EFC393E1BEC65792" modified="2013-03-06" version="1">MGKMSCQEKKSEDCKSRWLICREGLPNEVKDYLKNFRVLMPNVLLTGVSQDMSNVYYMFYTQRGSGFFVEMDNTYFNFSECREIIKGDLLTNIPRLVRSDENLRLVEYIIDNIMFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA21</accession>
    <name>L0AA21_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ordered locus">Calag_1026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer of catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232645.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1026"/>
    <dbReference type="EnsemblBacteria" id="AFZ70748">
        <property type="protein sequence ID" value="AFZ70748"/>
        <property type="gene ID" value="Calag_1026"/>
    </dbReference>
    <dbReference type="GeneID" id="14212286"/>
    <dbReference type="KEGG" id="clg:Calag_1026"/>
    <dbReference type="eggNOG" id="arCOG00911">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_1_2_2"/>
    <dbReference type="OMA" id="FPTEREY"/>
    <dbReference type="OrthoDB" id="51351at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="154"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="309" mass="34744" checksum="1715BC1E322BE14A" modified="2013-03-06" version="1">MVWSGHDVVNVLDFNREDLELLFSKADDMRKQLKENHVRKILSDKIIGLAFFEPSTRTRMSFETAAKRLGAETVGFTGEEGTSVAKGESFADTIKMLDSYVDAIVLRHKYEGAALFAADVAEHPIINGGDGRSHHPTQAFLDLYTTRTLFDRIDGLTFALVGDLKYSRTVSSLIFALSMFKPKEIILISPPQLGLREEIKLFALNHGLKLREEKDISVISDADVIYVTRIQKERFPDLQEYEKVRGSYKITKKLLETYAKKTAKVLHPLPRVDELSPDVDKTSYQGYFTQASLGVPLRMALLSLVLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA23</accession>
    <name>L0AA23_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Shikimate kinase</fullName>
            <shortName evidence="10">SK</shortName>
            <ecNumber evidence="5 10">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aroK</name>
        <name evidence="13" type="ordered locus">Calag_0112</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="5 10"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0112"/>
    <dbReference type="EnsemblBacteria" id="AFZ69900">
        <property type="protein sequence ID" value="AFZ69900"/>
        <property type="gene ID" value="Calag_0112"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0112"/>
    <dbReference type="eggNOG" id="arCOG01025">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073768_0_0_2"/>
    <dbReference type="OMA" id="WDVLVWT"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00370">
        <property type="entry name" value="Shik_kinase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010189">
        <property type="entry name" value="SK_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF3">
        <property type="entry name" value="PTHR20861:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01920">
        <property type="entry name" value="Shik_kin_archae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="66"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ69900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="259" mass="28439" checksum="A46917A3E80302B9" modified="2013-03-06" version="1">MVRIQAKMHIAYAGVSIVNAIPCGIGAVLPINLKAFAKEGKRNRNSPLINAIEDYLIKNYKIKTSFEVYSEIPEGVGLKSSSAVSVAIISSISHKLGDVYPPKLSAIITKNYNLSITGAFDDAVASYEGKISFTDNINLKILKLEKPSHDLKVIIFINDKRHDLNLSLMRENCKSFKIAFEKAFNGNIYEGIKINGYLMSEINGYDKKILDLMMEKGALTAGISGNGPAYFSLVKEGEEGPILDYLSNKGKIIVSEVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA29</accession>
    <name>L0AA29_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232655.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1036"/>
    <dbReference type="EnsemblBacteria" id="AFZ70758">
        <property type="protein sequence ID" value="AFZ70758"/>
        <property type="gene ID" value="Calag_1036"/>
    </dbReference>
    <dbReference type="GeneID" id="14212296"/>
    <dbReference type="KEGG" id="clg:Calag_1036"/>
    <dbReference type="eggNOG" id="arCOG00692">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_1_0_2"/>
    <dbReference type="OMA" id="TDNFMAN"/>
    <dbReference type="OrthoDB" id="75040at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="210"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="366" mass="41116" checksum="48B3F4A6F9AFA712" modified="2013-03-06" version="1">MQIKAGIALINEDLEIIKDVCIEINDEGIIESIGKGSTCNNYIGNDNIIAIPQPANAHVHSADNSFPEYGIDKNLHELVSYPDGLKHKLLNSLSYNKLVSGISSFYRTAYSLGLGLVVDFREGGGIGCKASKEASKDIKDMDIIVLGRPGNDFPNNCDGLGISSPIDYDENYVIELSRKFKPSMTHIAEDEETRNNNDFEIAMKSDFNALIHGLYLRNDDFEILKNKNVYLIFCPSSNLWHGKKFPPIDLSLKYNIKFAIGTDNASWFIPDVYREAYQLLLYLRLNQIKGEEIAKEILKSLYINGYKAVGVNPKIIKEGMPSHFLLIDGYSSSIINSLNLYNSIVKRVQKGFITYRVDKNNLIKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA36</accession>
    <name>L0AA36_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle 54 kDa protein</fullName>
            <shortName evidence="8">SRP54</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">srp54</name>
        <name evidence="12" type="ordered locus">Calag_0998</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="8">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232618.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0998"/>
    <dbReference type="EnsemblBacteria" id="AFZ70721">
        <property type="protein sequence ID" value="AFZ70721"/>
        <property type="gene ID" value="Calag_0998"/>
    </dbReference>
    <dbReference type="GeneID" id="14212258"/>
    <dbReference type="KEGG" id="clg:Calag_0998"/>
    <dbReference type="eggNOG" id="arCOG01228">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_2"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="OrthoDB" id="25871at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54_N" evidence="11">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="96"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="10">
        <location>
            <begin position="97"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="186"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="246"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="446" mass="49833" checksum="3D82E2B9310B923D" modified="2013-03-06" version="1">MVLEGLRNAVTKFLKGGSTYKDSVEEFIKDLQRELIKSDVNIKLVKELSENIKKKALEEEPPSGISRKEWFIKIVYDELSNLFGGDTTPDVEPKKIPWIILLVGVQGSGKTTTAGKLASFYVKKGYKVGLVAADTYRPGAYEQLKMLSNLSGAMFYGDQNNNKAEEISINGVEYFKNKNADIIIIDTAGRHGYGNEKSLLDEMRNISNKVKPDEVILVLDSSIGQKAFDLAKQFHETTPIGSIIVTKLDGTAKGGGVLSAIAATGARVKFIGTGEKIDELELFNPSKFVSRLLGLGDLDALLEKIKSVQDNINIEKLQEDLAKGKITMRTLYAQLKSLRKMGPFSKILQMLPTSSLPVQIKNEQLKIGEEKVDKWLHIIESMTYEELDNPDIIDRKRMRRIAIGSGTSIEDVKDLIVYYKNLKAIMKRIKRDRGILKKLGMQNIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA88</accession>
    <name>L0AA88_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase/AMP-acid ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231935.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0256"/>
    <dbReference type="EnsemblBacteria" id="AFZ70037">
        <property type="protein sequence ID" value="AFZ70037"/>
        <property type="gene ID" value="Calag_0256"/>
    </dbReference>
    <dbReference type="GeneID" id="14211516"/>
    <dbReference type="KEGG" id="clg:Calag_0256"/>
    <dbReference type="eggNOG" id="arCOG04201">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_10_2"/>
    <dbReference type="OMA" id="GPVGCRY"/>
    <dbReference type="OrthoDB" id="3223at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="54"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="442"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="540" mass="61051" checksum="B370F6A9EC119F68" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA91</accession>
    <name>L0AA91_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1 2">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysC</name>
        <name evidence="3" type="ordered locus">Calag_1059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1 2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1059"/>
    <dbReference type="EnsemblBacteria" id="AFZ70781">
        <property type="protein sequence ID" value="AFZ70781"/>
        <property type="gene ID" value="Calag_1059"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1059"/>
    <dbReference type="eggNOG" id="arCOG01040">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046932_2_3_2"/>
    <dbReference type="OMA" id="GVTIWFT"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="184" mass="21410" checksum="5F5C53F2EA054399" modified="2013-03-06" version="1">MIKMKCLDKGLVFWLTGLSGSGKTTIGNLVKERLRKEGYKAEIIDGDWFRQNIDQNAGYTKEERRKHLIRVANFVKILARNGVITICSFVSPYEDVRNEVKNIIKSEADFYLIYVKCDLEECIKRDPKGLYKKALKGEIKNFTGIDDPYEEPKEYDLLLDTVNNSIEENVNKLYEFINKKINEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAB8</accession>
    <name>L0AAB8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EamA-like transporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232267.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0613"/>
    <dbReference type="EnsemblBacteria" id="AFZ70369">
        <property type="protein sequence ID" value="AFZ70369"/>
        <property type="gene ID" value="Calag_0613"/>
    </dbReference>
    <dbReference type="GeneID" id="14211873"/>
    <dbReference type="KEGG" id="clg:Calag_0613"/>
    <dbReference type="eggNOG" id="arCOG00272">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014109_0_0_2"/>
    <dbReference type="OMA" id="VARICFY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="9"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="151"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="288" mass="30384" checksum="A44AD5512746356B" modified="2013-03-06" version="1" precursor="true">MALISYGLAVALALGSGIGFAINDAIAKLKVKGNNSMSLTFISLLFGLPIIMISLLFPVGRFTMTLKAFIVYIFAGLVNFTIGRTSLYASISRLSSSGGSILSSTSALFGFIMGWLILNEHVTYIMAIGVILIMISVYIASGGFKSEISLSGILFGLITGLSIAIAVILIKIGDQSGGQPVLGTLIAYLSGLSFSFIGFKRNPISKKEIKDLLIPLLLMSNSAAAGQVMRYIALLTAEASVVAPLQNIRPVVATFILLAFGVGEKRPKKYHWIAAILASIGAALVSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAD4</accession>
    <name>L0AAD4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70831">
        <property type="protein sequence ID" value="AFZ70831"/>
        <property type="gene ID" value="Calag_1109"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1109"/>
    <dbReference type="eggNOG" id="arCOG08615">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1551730_0_0_2"/>
    <dbReference type="OMA" id="MAERIFN"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="166" mass="19298" checksum="BFE423A76A952046" modified="2013-03-06" version="1">MMSWEKEGYKLIYKKSNKGDFILLKGNIQQERERVLLKIGGKNIEKIFNEIEKVLKEKKLIEEESSSNNSIRLKLNQDIGPIVAGFLILIRRSREPLDWITYFEPLIQGDKYLGSKEVLYHIWFLSVDLSNSINKKLSLKYQLNPKILDSVGAATKIIAKKMWKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAD5</accession>
    <name>L0AAD5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="7">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="7">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pheS</name>
        <name evidence="9" type="ordered locus">Calag_0297</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="7"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0297"/>
    <dbReference type="EnsemblBacteria" id="AFZ70077">
        <property type="protein sequence ID" value="AFZ70077"/>
        <property type="gene ID" value="Calag_0297"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0297"/>
    <dbReference type="eggNOG" id="arCOG00410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_2_2_2"/>
    <dbReference type="OMA" id="QIEGWVM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00282">
        <property type="entry name" value="Phe_tRNA_synth_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022917">
        <property type="entry name" value="Phe_tRNA_ligase_alpha_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="236"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="478" mass="55580" checksum="C4255AF2606208F2" modified="2013-03-06" version="1">MGEEKIGVSESEYYILKTLSNKKIKEFNIEDGEKILNIDKSKLASILRLLESKKLLEIIETNKKILRLTEKGKKALEEGLPEEKLIKFLKDNKSLDINFVKEKLGEETNIAIGQGKKLKIIDLNDGKVTLKVDFDDAIRKVNSIVDSLKNMSFDKNLEKEFISRGLIKEDYIKEVKVIVREDAINKVELLTSKISHELLAKGLWKDLKLREYDIRSEPPIVYPARKHFFVEFIEELKDIMKELGFKEVQGPLIEIELFNFDILFQPQDHPAREIHDTLWIKDPRYADLNNMKEIINRVSSVHERGWKYKFNPEISSRYVLRSQTTSVSARLLISKPKPPVRFFTIGKVYRSDVIDASHLPEFHQLDGIMGDYDYNFRDLLGILKEFGDRLGIEIKFKPGYFPFTEPSVEGYAKINDKWIELFGAGLFRPEVLEMANIDYKVGAWGMGVERLIMARLGLSDIRLLYETNYDFLRSFKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAE1</accession>
    <name>L0AAE1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232775.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1156"/>
    <dbReference type="EnsemblBacteria" id="AFZ70878">
        <property type="protein sequence ID" value="AFZ70878"/>
        <property type="gene ID" value="Calag_1156"/>
    </dbReference>
    <dbReference type="GeneID" id="14212416"/>
    <dbReference type="KEGG" id="clg:Calag_1156"/>
    <dbReference type="HOGENOM" id="CLU_2433685_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="90" mass="10362" checksum="A1E281E749EA7C84" modified="2013-03-06" version="1">MLDESSWELQKERPMALVLAIIEKTHEKTPISISNYMKKLINIDSWIGRYSLLLSENPDEIAKIINDLDLGVLPRKDLVKKVLDTISKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAE7</accession>
    <name>L0AAE7_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Replication factor C small subunit</fullName>
            <shortName evidence="6">RFC small subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Clamp loader small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rfcS</name>
        <name evidence="8" type="ordered locus">Calag_0647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the activator 1 small subunits family. RfcS subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0647"/>
    <dbReference type="EnsemblBacteria" id="AFZ70399">
        <property type="protein sequence ID" value="AFZ70399"/>
        <property type="gene ID" value="Calag_0647"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0647"/>
    <dbReference type="eggNOG" id="arCOG00469">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_2_1_2"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01509">
        <property type="entry name" value="RfcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023748">
        <property type="entry name" value="Rep_factor-C_ssu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="47"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="333" mass="37919" checksum="402621171B3DCD9E" modified="2013-03-06" version="1">MHLINGEKMSSVTELLWTEKYRPRTLKDIINQQDITTRLMKFVQEKNMPHLLFAGPPGTGKTTAAHALAHDLYGESYQQFMLELNASDERGIDTIREKVKEFARSKTPPEIPFKIVLLDEADNMTSDAQQALRRLMELYSASTRFILAANYPSKIIDPIQSRCAFFRFTSLKKEDVIDRLKYIADKEGVDYEEDALDIIFEISEGDMRKAINILQASAYLGKVTSELVFKVVGMARPKDITDMIETALKGNFIEAREILRKVMIEYGLSGEDVVKQIHREIMGPDIKINDELRVLIADYLGEIHFRISEGSDEDIQLSAFLAWLSMMGKKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAI6</accession>
    <name>L0AAI6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0275"/>
    <dbReference type="EnsemblBacteria" id="AFZ70055">
        <property type="protein sequence ID" value="AFZ70055"/>
        <property type="gene ID" value="Calag_0275"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0275"/>
    <dbReference type="eggNOG" id="arCOG03654">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031607_0_0_2"/>
    <dbReference type="OMA" id="IAPWAIF"/>
    <dbReference type="OrthoDB" id="44826at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="43"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="481" mass="53155" checksum="A5232661673D56D7" modified="2013-03-06" version="1">MQKLMLDESDPKPAETDSIANYLRLRRTTTLKRKLSFRDLFFLSLGGQAPFLSLLTYATGVIIYSFLFSPLIIILGALLVLINGLVVYKLSKKYQEAGGYYIYAMYSLTRRLGLETGWMYIFYSAFYGSAYIVGASFLLHYVFNLNPLISALIVFIPAITFLIMGTKPSAKYAEFSGIIEIAFIALISIIGIYLAHFHFYNPIQKVPSINKIALAILFAIGIPTGYGSITPLSEESINHKDIGRAALLVIIVGGLVTGFAIYGLIDAGLYTSQLSSIITSSVPILNLLKENFGIIALIFMIYAAISDGILASLSFMLGTSRTVYAMAQKEMLPSVFTWLRGNEPIMASILTAIIYGAISFLGLITIKNPFYLFLEFGAIAGLSNVFVHLSANFSLVLSSIRDLKNRAKIIGTYAIEKIFNFIINKTTDLIIGISAILFSLIVLLYSMATVNKIVENLFMGWIIIGFLYAEIVDSIKQNHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAJ9</accession>
    <name>L0AAJ9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0285"/>
    <dbReference type="EnsemblBacteria" id="AFZ70065">
        <property type="protein sequence ID" value="AFZ70065"/>
        <property type="gene ID" value="Calag_0285"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0285"/>
    <dbReference type="eggNOG" id="arCOG01411">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_833206_0_0_2"/>
    <dbReference type="OMA" id="THAFFLN"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="169"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="351" mass="40861" checksum="2C36079881945E32" modified="2013-03-06" version="1">MMKVMLVSEIDGRTNRLRRGPYLRYKFHPNNIEYTIFYDIIPPFKKASQYEYNKDTMIATLSRLILKGISQPIPKDEKIIHSFFWNFYLYSKPWVHENDESPSQFLDQYYGGKGFTYNVALDFLTYYLNSSPCRAIITWSEWARKGFIKDGVDSSKVVVIPPPMQINSEKRINHRDINILFIGRDFIRKGGDIALKVFLKLAKEFDNINLFYVGPIPGNIKKIVNNHKNIYHYEKLSDDELYNKIMPLSDITFLPTRYDAYALTILESMSYGIPVVSSNINSINETITHGNNGFVGNYEEEYEKYISVLITNENIRKSFSENSVQAIKERHDPVIIGNELIKVYENVISGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAK3</accession>
    <name>L0AAK3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232845.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1231"/>
    <dbReference type="EnsemblBacteria" id="AFZ70948">
        <property type="protein sequence ID" value="AFZ70948"/>
        <property type="gene ID" value="Calag_1231"/>
    </dbReference>
    <dbReference type="GeneID" id="14212491"/>
    <dbReference type="KEGG" id="clg:Calag_1231"/>
    <dbReference type="eggNOG" id="arCOG08092">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058421_6_4_2"/>
    <dbReference type="OMA" id="IKANKNA"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="143" mass="15652" checksum="0A1BEACA750346E9" modified="2013-03-06" version="1">MITYLFEASIGILLVRLIMGINMIGHGSVKFKDLKGTAKYMKGAGVPEGLTYATALLELVGGIALVLGFLTRLASLLFFLQFLIIILYVKITRMKSPYLMITNPAAAEIDTIYMIISLALLISGPGIYSVDYLLKNYLLNGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAL1</accession>
    <name>L0AAL1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0295"/>
    <dbReference type="EnsemblBacteria" id="AFZ70075">
        <property type="protein sequence ID" value="AFZ70075"/>
        <property type="gene ID" value="Calag_0295"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0295"/>
    <dbReference type="eggNOG" id="arCOG04301">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062816_1_0_2"/>
    <dbReference type="OMA" id="PCSQGMS"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003933">
        <property type="term" value="F:GTP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003801">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2/MptA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36445">
        <property type="entry name" value="PTHR36445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02649">
        <property type="entry name" value="GCHY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="290" mass="32552" checksum="4D4C26C318D60E57" modified="2013-03-06" version="1">MNLLEIQDMKPNYTIPIKRVGFKGLWKRAYIESPLGVMPIDLEINAYVEIPEDKKGAHLSRNVEALPEDMEFPTKAKSIEYYLEKIHNSLLRLHSYAKTARVEAKTRYGVEIKFNDLSEMEPVDVLISVDGDLNHKRWSITVGLYGMTACPSAQSTISSIINSNTISPSHSQKVLLYGTIETEENYIIRIEDIARCLSNAFSAPSFTLLKRMQEANLVISAHKNPKFVEDVVRDAIGGLRCLTESLPENTVIKAEAISLESIHPHNVYAYSEGIKSSLPALNCKKLCNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAM2</accession>
    <name>L0AAM2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps15</name>
        <name evidence="6" type="ordered locus">Calag_0451</name>
        <name evidence="7" type="ordered locus">Calag_0729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute (JGI-PGF)"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 15908</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232116.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0451"/>
    <dbReference type="EnsemblBacteria" id="AFZ70218">
        <property type="protein sequence ID" value="AFZ70218"/>
        <property type="gene ID" value="Calag_0451"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70474">
        <property type="protein sequence ID" value="AFZ70474"/>
        <property type="gene ID" value="Calag_0729"/>
    </dbReference>
    <dbReference type="GeneID" id="14211989"/>
    <dbReference type="KEGG" id="clg:Calag_0451"/>
    <dbReference type="KEGG" id="clg:Calag_0729"/>
    <dbReference type="eggNOG" id="arCOG04185">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090139_2_0_2"/>
    <dbReference type="OMA" id="EEHPKDM"/>
    <dbReference type="OrthoDB" id="98179at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_S15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_S13/S15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_S15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="PTHR11885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S13_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="151" mass="17327" checksum="016D72ACCA921B40" modified="2013-03-06" version="1">MHKNSRRGKSHSIRPSTFTANWITYSQQEVEMIIEELAKKGYTPSQIGLVLRDQFGIPLVKPIIGKKVGKVLEEKNLSPKIPEDLFNLIRKAVNLRRHLNEHPKDKTSMRGLIFTESKIRRLSNYYKKVGKLNKDWVYDPNAAKLLVAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAN9</accession>
    <name>L0AAN9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ubiquinone-dependent succinate dehydrogenase or fumarate reductase, flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_0311</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231988.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0311"/>
    <dbReference type="EnsemblBacteria" id="AFZ70090">
        <property type="protein sequence ID" value="AFZ70090"/>
        <property type="gene ID" value="Calag_0311"/>
    </dbReference>
    <dbReference type="GeneID" id="14211571"/>
    <dbReference type="KEGG" id="clg:Calag_0311"/>
    <dbReference type="eggNOG" id="arCOG00571">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_2_2"/>
    <dbReference type="OrthoDB" id="8547at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="9">
        <location>
            <begin position="9"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="10">
        <location>
            <begin position="457"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="583" mass="65517" checksum="3344D4BCFC19C7AD" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAQ9</accession>
    <name>L0AAQ9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="8">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysS</name>
        <name evidence="11" type="ordered locus">Calag_1289</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="8"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232900.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1289"/>
    <dbReference type="EnsemblBacteria" id="AFZ71003">
        <property type="protein sequence ID" value="AFZ71003"/>
        <property type="gene ID" value="Calag_1289"/>
    </dbReference>
    <dbReference type="GeneID" id="14212549"/>
    <dbReference type="KEGG" id="clg:Calag_1289"/>
    <dbReference type="eggNOG" id="arCOG00486">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_2"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="OrthoDB" id="20883at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="10">
        <location>
            <begin position="16"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="265"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ71003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="476" mass="55641" checksum="7576FF1415623EBE" modified="2013-03-06" version="1">MLRIQNTYGKKVEIFNPWNESIVNMYVCGPTVYDYTHIGHARTFVVFDAIKRYLSLKGYNIVYVQNITDIDDKIINRAKEKNVPWQEIANTYAIDYLNNLNKLNIKIDIHPRVTNHINEIINFIQNLIDKGYAYVSQSGSVYFSVDKYPNYGRLSNNFNKAYWNQGEGIVSEKKNPYDFALWKSYKEGEPYWESPWGKGRPGWHIECSVMSSRYLGNKIDIHGGGSDLIFPHHENEIAQSEAYFGSSPWVKYWLHTSMLTIKGEKMSKSLGNIISLNDAINTWGSNVLRLWLLSSHYRAIIEYSEQSLNQAKRLYERLNALSQEIVKRLKKEEYTSYMNNDDLEAFNNLKELISKWHDAMDNDFNMSEAIRYVWDLTDLYYKKIQNSESYALISYTYKVLQDMNKVYGVLDDVLTLDLHIEKNLTPELIDLILEVRKQLRENKLYDLADQIRSKLSSIGVKIIDKGNKSDYLITNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAS3</accession>
    <name>L0AAS3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232421.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0782"/>
    <dbReference type="EnsemblBacteria" id="AFZ70524">
        <property type="protein sequence ID" value="AFZ70524"/>
        <property type="gene ID" value="Calag_0782"/>
    </dbReference>
    <dbReference type="GeneID" id="14212042"/>
    <dbReference type="KEGG" id="clg:Calag_0782"/>
    <dbReference type="eggNOG" id="arCOG00463">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115699_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002837">
        <property type="entry name" value="DUF123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37460">
        <property type="entry name" value="PTHR37460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01986">
        <property type="entry name" value="DUF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="161" mass="19001" checksum="1133A00B1EC9415C" modified="2013-03-06" version="1">MNKQIHGNQIYNIWSQILSKEGIYIIVFRVNDYINLIINKNEFIIDKGYIIYIGSAGNGLNNRLRRHLTKNKKLRWHIDYVTNNKSVEPSIIYYKEGLYGVKIEDELSSLFYSKFLKIDNLGATDSKMPHMYYSNNIKEILKIIYKLDGSIIIFPSIFDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAT5</accession>
    <name>L0AAT5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-methyltransferase Dcm</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232893.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1282"/>
    <dbReference type="REBASE" id="57668">
        <property type="entry name" value="M.Cla15908ORF1282P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70996">
        <property type="protein sequence ID" value="AFZ70996"/>
        <property type="gene ID" value="Calag_1282"/>
    </dbReference>
    <dbReference type="GeneID" id="14212542"/>
    <dbReference type="KEGG" id="clg:Calag_1282"/>
    <dbReference type="eggNOG" id="arCOG04157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006958_2_2_2"/>
    <dbReference type="OMA" id="EPFTGAN"/>
    <dbReference type="OrthoDB" id="58937at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="322" mass="37028" checksum="A799A3C57232DF9B" modified="2013-03-06" version="1">MKTKFSVLDIFSGGGGFSRGFKEAGFNILVSIENDPPVAKTYKANFPETMLIADDAKEIDYNVFKSFGYQRNDFDVIIASPPCEPFTPTNKKRKEVPIDRLYCDPIGQLYLHAIRLINEMRPRFFVIENVAGILHDDIKASITKELKKAGYNEVYFNVLYAEYHGVPSIRTRVFVSNLYLNLKKQKIISVEEALKDLPNPGTYYPPNHEEPQPLTKKLRKRVSSAKWGRAMIEFEGAENKRFRNFIRLNPYRPAPTIMGSSRFIHPFEDRLLTVREQARLMGFPDYHVFLGGRDSQYNMVGEAVPPPLAKEIANYIINYLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAW1</accession>
    <name>L0AAW1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232058.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0387"/>
    <dbReference type="EnsemblBacteria" id="AFZ70160">
        <property type="protein sequence ID" value="AFZ70160"/>
        <property type="gene ID" value="Calag_0387"/>
    </dbReference>
    <dbReference type="GeneID" id="14211647"/>
    <dbReference type="KEGG" id="clg:Calag_0387"/>
    <dbReference type="eggNOG" id="arCOG04135">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196483_0_0_2"/>
    <dbReference type="OMA" id="CGRVFPE"/>
    <dbReference type="OrthoDB" id="127163at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="81" mass="9419" checksum="5DA0330CA57AB682" modified="2013-03-06" version="1">MVKQEYECIVCGKKFNEGQGIVLTKGSLKLTFHSSKCVSKFFKLYLERLDESCSEKSARDLIKELEKIREEKQKQTKKVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAY7</accession>
    <name>L0AAY7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Preprotein translocase subunit Sec61beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Calag_0531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232190.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0531"/>
    <dbReference type="EnsemblBacteria" id="AFZ70292">
        <property type="protein sequence ID" value="AFZ70292"/>
        <property type="gene ID" value="Calag_0531"/>
    </dbReference>
    <dbReference type="GeneID" id="14211791"/>
    <dbReference type="KEGG" id="clg:Calag_0531"/>
    <dbReference type="eggNOG" id="arCOG02957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208205_2_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="58" mass="6436" checksum="84D879B6A22D496F" modified="2013-03-06" version="1">MSTKPKKRSSKKKQTSPMTAAGLISFYEDYESKIEISPTTLIIISAAVAIIIIFARFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAZ3</accession>
    <name>L0AAZ3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exosome complex component Rrp42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rrp42</name>
        <name evidence="5" type="ordered locus">Calag_0432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family. Rrp42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232098.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0432"/>
    <dbReference type="EnsemblBacteria" id="AFZ70200">
        <property type="protein sequence ID" value="AFZ70200"/>
        <property type="gene ID" value="Calag_0432"/>
    </dbReference>
    <dbReference type="GeneID" id="14211692"/>
    <dbReference type="KEGG" id="clg:Calag_0432"/>
    <dbReference type="eggNOG" id="arCOG01574">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_0_0_2"/>
    <dbReference type="OMA" id="PESVFEM"/>
    <dbReference type="OrthoDB" id="64101at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11365">
        <property type="entry name" value="RNase_PH_archRRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00622">
        <property type="entry name" value="Exosome_Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020869">
        <property type="entry name" value="Rrp42_archaea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="3">
        <location>
            <begin position="38"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="4">
        <location>
            <begin position="198"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="284" mass="31637" checksum="3D40753F8AB3531F" modified="2013-03-06" version="1">MSTTPYRTQIIPKIKRDVYLNLYRKGQRADERDFYSPRKISIQTNVLEKANGSALVKLGNTQVLAGIKIEPGEPFADMPDEGVLQVHAELVPLASPQFEPGPPDENAIELARVIDRSLRDPKAVDLKSLVIRPGDKVWMLWLDLYILDYDGNLFDASMLASMAALSTARMPEFEEMETGEIKLTNKISDIPIKLNKRIVTVTTAKIENYIIVDPNLDEEIISDTRSVISFDENGNIVGVQKTGMGSVSQEELDNIVNISSQAAQVYFKLLNNALVSEKKEEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB04</accession>
    <name>L0AB04_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ethylbenzene dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232958.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1352"/>
    <dbReference type="EnsemblBacteria" id="AFZ71061">
        <property type="protein sequence ID" value="AFZ71061"/>
        <property type="gene ID" value="Calag_1352"/>
    </dbReference>
    <dbReference type="GeneID" id="14212612"/>
    <dbReference type="KEGG" id="clg:Calag_1352"/>
    <dbReference type="eggNOG" id="arCOG06015">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_575729_0_0_2"/>
    <dbReference type="OMA" id="WIFILEK"/>
    <dbReference type="OrthoDB" id="16612at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019020">
        <property type="entry name" value="Cyt-c552/DMSO_Rdtase_haem-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09459">
        <property type="entry name" value="EB_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="EB_dh" evidence="7">
        <location>
            <begin position="63"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="400" mass="43276" checksum="C1EC69F31C04641F" modified="2013-03-06" version="1" precursor="true">MSPKRIVKKYFIILVIISASLAIIGLLHGNLTNITKAQTVSAVPQIIAYKITGSANLKDPGSESFWSQIPWTVIPLSANVPGGGHTSQIMVKAAWNGTYLFVLLTWNVTKPSHHLSSVFSLGGGPFGYPPLWYNQSSNSYVVAPPRVDEETIVKSYYVNSTYYSQDRVAMMWYLGGQSGTPNDCMVVGASNGGALAAGGAANIWDFMMGATWNGTQLVSPALGMSPVPEYTYYNWWNHNVSFTGVNYQAPPTGFALNLYTNASNLYEVGLGTGLFYTDVDTNHTNPFDVLAGAYNTSHTWVVEMARQMGYVPGAGQYEVNLTPGSTYDVAFAVWQGYLGENAFIKSISTFVPLVISNSSPTTTTSPVTSTVNMTLVYTEVSAIVIMVVAAVILYFALRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB12</accession>
    <name>L0AB12_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEMO1 family protein Calag_0848</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0848"/>
    <dbReference type="EnsemblBacteria" id="AFZ70589">
        <property type="protein sequence ID" value="AFZ70589"/>
        <property type="gene ID" value="Calag_0848"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0848"/>
    <dbReference type="eggNOG" id="arCOG01728">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038085_2_0_2"/>
    <dbReference type="OMA" id="EQEAQYG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PTHR11060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="279" mass="31298" checksum="C00B52F4D81CA2F4" modified="2013-03-06" version="1">MPAHAGSFYPSKKDDLIKSIESSYLHKLGPGMLPNAERERKKESIGYMVPHAGYIYSGPIAAHSYFNISKEGKPKVFIIAGPNHTGLGENASVWKEGIWETPLGEVEVDSEISKLLVSYSKYFTFDEEAHIYEHSVEVQIPFLQYIFKDIKIVPIVIKLQNYEVSLDLANALYRIITENGVDLIYIASSDMNHYEPYDITYKKDEIALKKIESLDTEGLFKVLDENNITMCGPGPVGALIHLSKKLNSKAEILKHATSGDITGEKDWVVGYASARFFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB15</accession>
    <name>L0AB15_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Calag_0469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0469"/>
    <dbReference type="EnsemblBacteria" id="AFZ70235">
        <property type="protein sequence ID" value="AFZ70235"/>
        <property type="gene ID" value="Calag_0469"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0469"/>
    <dbReference type="eggNOG" id="arCOG00561">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032023_0_0_2"/>
    <dbReference type="OMA" id="MLDIHVA"/>
    <dbReference type="OrthoDB" id="115811at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="92"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="393" mass="43264" checksum="02FE7FC2AB5D457C" modified="2013-03-06" version="1">MGFDLNLNTEKLKRISFIIGFIITIGFSYMVGISAYHIATTTNGGGYNNSYISDEIYYVDSARRILVNVFGYKGATYPYSGETLSTYYNFEHPPLAKYIIALSMALLGDKPINWRIPSILMASLIPLIIYLGISIKNDIKWIFLGTIAAMISSSDHILIVMGSVALLDIYAAFFLTIAIVMAFRKRLLLSAVFVGLSAASKETGLFGVLALIILIFALYGKKAEALRKIGEVILIILAVILVVYIPLFYHFGVLNILQQTIGGLKWDLQSRPPGPPTSSPSGWLFNVDPFILSYSPLLEASTTPVIEVPAMISAISIFITCLLYKREYCCNVGSVFYVSIFLGFWLVYLSGNRTLYSFYSVILTPAAAFTLIEALNLIIGGKNGKAENNNSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB20</accession>
    <name>L0AB20_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LAO/AO transport system ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0474"/>
    <dbReference type="EnsemblBacteria" id="AFZ70240">
        <property type="protein sequence ID" value="AFZ70240"/>
        <property type="gene ID" value="Calag_0474"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0474"/>
    <dbReference type="eggNOG" id="arCOG01226">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043725_1_0_2"/>
    <dbReference type="OMA" id="DWRPPIV"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="328" mass="35618" checksum="AC90674DE8ABB9DC" modified="2013-03-06" version="1">MSITETMLDDLLNKASNGNMRAIGRILSYLENPYTMPEDLLEKLAKRSGKAQIIGITGIPGSGKSTLISKLITSLRKKGYKVAIIAIDPSSPISGGALLGDRLRMQEHATDPGVFIRSVSSKGLKGGLSLAALAMIEAFDALGYEKIIIETVGVGQSEVDIMSAADTIVVVTMPGAGDDIQALKAGVMEIGDIYVLNKMDKEEANKTYEYLSFALEKGDLGGNDSNWQPRLIKTSAIMGKGIEELVQAIEDHFSFIKESNKLQEKLVSRRMLMINLLAEQFLSEGLKLASKELYDELKSSAINANNIFNTSLKLAKKAVDFLPQNKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB23</accession>
    <name>L0AB23_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl22</name>
        <name evidence="7" type="ordered locus">Calag_1372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="4 6">This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232978.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1372"/>
    <dbReference type="EnsemblBacteria" id="AFZ71081">
        <property type="protein sequence ID" value="AFZ71081"/>
        <property type="gene ID" value="Calag_1372"/>
    </dbReference>
    <dbReference type="GeneID" id="14212632"/>
    <dbReference type="KEGG" id="clg:Calag_1372"/>
    <dbReference type="eggNOG" id="arCOG04098">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_0_2_2"/>
    <dbReference type="OMA" id="ANAEYKG"/>
    <dbReference type="OrthoDB" id="103467at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_A">
        <property type="entry name" value="Ribosomal_L22_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_L22/L17_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="PTHR11593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ71081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="157" mass="17982" checksum="3EAF3D304731BE60" modified="2013-03-06" version="1">MPQWNYSVKLQDESKVAKAVIREVPVHPKVIVEIANAINGMNLKKAERFLENVIKQKEPLPFRRSNKKVSHRRGLSDRWGVPSGRYPIKAATYVLNLLRNVENNADNKGLEIDKLVIYHIGVSKGLTLKRAMPRAFGRADILRKFRSNIEIIVRMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB29</accession>
    <name>L0AB29_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232245.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0590"/>
    <dbReference type="EnsemblBacteria" id="AFZ70347">
        <property type="protein sequence ID" value="AFZ70347"/>
        <property type="gene ID" value="Calag_0590"/>
    </dbReference>
    <dbReference type="GeneID" id="14211850"/>
    <dbReference type="KEGG" id="clg:Calag_0590"/>
    <dbReference type="eggNOG" id="arCOG01618">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_2"/>
    <dbReference type="OMA" id="DAAKPHG"/>
    <dbReference type="OrthoDB" id="43721at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="329" mass="36799" checksum="9D924906781DF507" modified="2013-03-06" version="1">MKYKVFGKTKIKISEVGLGFWQIGSTSWKGDISKAKEIVKQALDSGINFFDTAEVYGNGKSEMSLGNAIKELNAIDSTFVATKVGGFRPTEYFIEKGIKRSIKNLGFKPHLLQLHWPPPIWIPLCSTIRGLEKMVDKGYVDFIGVSNFSGKLLNEAIHCTSKHEIISNQIEYNLAYRVPEIDIFPLAKKENVEIIAYSPLAKGALAGALNPNSLAQKSDKKFNIIKNDNELISTLNSISQKRGYTWSQISLKWLINNNTLPIPGTRNKNRVIEYANSSEIELDKEELSLLNSVTNKYVNMWGNKYGNLNSIRYVPCILQYIGIKIAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB30</accession>
    <name>L0AB30_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal-transduction protein containing cAMP-binding and CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0595"/>
    <dbReference type="EnsemblBacteria" id="AFZ70352">
        <property type="protein sequence ID" value="AFZ70352"/>
        <property type="gene ID" value="Calag_0595"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0595"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_1_2"/>
    <dbReference type="OMA" id="YGICELC"/>
    <dbReference type="OrthoDB" id="83765at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="80"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="148" mass="16282" checksum="469DF343BCB34D21" modified="2013-03-06" version="1">MSASVPKYLVRDVMRTPTVNILPTKSVSEIARLMIDRDVGSVLVVNEEGNLLGIITKTDIVREVVAKGLSPLNINASQIMTKNPYYAFEDVPLEEAASLMGSKGVGHLPILDSRTLKPIGMLSKRDILKLAPYYIDLVYQLKAEKIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB74</accession>
    <name>L0AB74_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0938"/>
    <dbReference type="EnsemblBacteria" id="AFZ70669">
        <property type="protein sequence ID" value="AFZ70669"/>
        <property type="gene ID" value="Calag_0938"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0938"/>
    <dbReference type="eggNOG" id="arCOG08157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538206_0_0_2"/>
    <dbReference type="OMA" id="HIAHSET"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="527" mass="60862" checksum="B747FBDF2ED1943F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB76</accession>
    <name>L0AB76_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH:ubiquinone oxidoreductase subunit 5 (Chain L)/multisubunit Na+/H+ antiporter, MnhA subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1436"/>
    <dbReference type="EnsemblBacteria" id="AFZ71143">
        <property type="protein sequence ID" value="AFZ71143"/>
        <property type="gene ID" value="Calag_1436"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1436"/>
    <dbReference type="eggNOG" id="arCOG01539">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_6_2_2"/>
    <dbReference type="OMA" id="LIGFWQH"/>
    <dbReference type="OrthoDB" id="28394at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="557"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="7">
        <location>
            <begin position="81"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="191"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="688" mass="76659" checksum="CCAD5E4BCFA8B8E5" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB96</accession>
    <name>L0AB96_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232310.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0661"/>
    <dbReference type="EnsemblBacteria" id="AFZ70412">
        <property type="protein sequence ID" value="AFZ70412"/>
        <property type="gene ID" value="Calag_0661"/>
    </dbReference>
    <dbReference type="GeneID" id="14211921"/>
    <dbReference type="KEGG" id="clg:Calag_0661"/>
    <dbReference type="eggNOG" id="arCOG04056">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184944_0_0_2"/>
    <dbReference type="OMA" id="HENEQPY"/>
    <dbReference type="OrthoDB" id="129209at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="87" mass="10196" checksum="B7224906ECC8433F" modified="2013-03-06" version="1">MDIEKILASKGKVRILKVLMKEGQINISRLAKLTGLHHDVIVKNMEELKEMGIVEEKRYGRLRIYMIDLRDPKISGLYEIFKEIENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABA1</accession>
    <name>L0ABA1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Saccharopine dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0666"/>
    <dbReference type="EnsemblBacteria" id="AFZ70417">
        <property type="protein sequence ID" value="AFZ70417"/>
        <property type="gene ID" value="Calag_0666"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0666"/>
    <dbReference type="eggNOG" id="arCOG00243">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032858_3_0_2"/>
    <dbReference type="OMA" id="PCEAIVD"/>
    <dbReference type="OrthoDB" id="71470at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sacchrp_dh_C" evidence="2">
        <location>
            <begin position="123"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="372" mass="41295" checksum="4D9084E3D94B7B36" modified="2013-03-06" version="1">MVFNLNIGIIGVGNVGKRAAYLLKNEGFNVTLFDYNENSLKKVSNELNLSYKKVNVLDMQSCLSLKDIDLAITSLPGSIAFNALKNIVSLGINVVDVSFFPEDPKDIGEIAEKNGVSVLLDAGVAPGLSNMLISYGMNKLGKINGGRIYVGGITQMPDPPFGIIASWNTMDLIDEYRRKARLISNGKVIEMDPLSSEIGKIYVKGVGELEYFPTDGLRSLLYTFNKLDYLAEYTLRWPGHIEFMRGLKKLGLLDHKKIKINDAEIYADEFLSNVIASYKSNLNDIVVLVVETLNKDKGIRFTQITTPENDFTAMSRVTGSFLSYAGIEFIKGKIKKKAGLLYPEYLGELDTGEDIINMMKKDGMPIIEEIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABA4</accession>
    <name>L0ABA4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1471</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233070.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1471"/>
    <dbReference type="EnsemblBacteria" id="AFZ71173">
        <property type="protein sequence ID" value="AFZ71173"/>
        <property type="gene ID" value="Calag_1471"/>
    </dbReference>
    <dbReference type="GeneID" id="14212731"/>
    <dbReference type="KEGG" id="clg:Calag_1471"/>
    <dbReference type="eggNOG" id="arCOG01465">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089201_0_0_2"/>
    <dbReference type="OMA" id="FTYYFVG"/>
    <dbReference type="OrthoDB" id="77595at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="272" mass="29981" checksum="EAB84625FE2E84BD" modified="2013-03-06" version="1">MASLSSIYSKLYSFVYLRGFKIWISYKTQVVLNVLSWVIPVFTYYFVGTSLGQKFVSYINTQNYTAFIVIGLAFQGYVSSVITTISGRMRNEQLFGTLEYYMLSPTGVFGMLFYSAAWGFVLNTINAVVIILVGLGLGVSFVNANIIGALIIIIELIISTLGLSMMAGGIVMITKQGNPISFFFSTITTLLSGTVFPVSILPGYIKDLSYAIPLTFALNGLRSALLNAASLTQLAYYFYILLIFDVVLLPLGAYIYKLGFDIARKQGTLSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABE4</accession>
    <name>L0ABE4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="7">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ileS</name>
        <name evidence="10" type="ordered locus">Calag_0712</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="7"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0712"/>
    <dbReference type="EnsemblBacteria" id="AFZ70457">
        <property type="protein sequence ID" value="AFZ70457"/>
        <property type="gene ID" value="Calag_0712"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0712"/>
    <dbReference type="eggNOG" id="arCOG00807">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_2"/>
    <dbReference type="OMA" id="HLGTAWN"/>
    <dbReference type="OrthoDB" id="4914at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="8">
        <location>
            <begin position="24"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="9">
        <location>
            <begin position="687"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="602"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="1058" mass="123608" checksum="A5E7065FF71B7D71" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABM9</accession>
    <name>L0ABM9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1573"/>
    <dbReference type="EnsemblBacteria" id="AFZ71271">
        <property type="protein sequence ID" value="AFZ71271"/>
        <property type="gene ID" value="Calag_1573"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1573"/>
    <dbReference type="eggNOG" id="arCOG03117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_1_1_2"/>
    <dbReference type="OMA" id="SNARFQF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="244" mass="27487" checksum="FC11933EC3CC8A57" modified="2013-03-06" version="1">MPTSKENNPTQTVKIGAYSLQENKKENLIISIIFILLTIFILFYHFLLGGNITQTMLNFSLKILNQAGYTGILILMTAESMLIPIPSEIVMPLAGILAKIGSLNIYLIITFGTVGNLIGSTILYFIGKYVRNPFVEFAVKYFRLNIKYVKLSDDLFDKHGSSIIFFGRIMPAIRSIISLPAGFSRMNLPKFGLYTLLGSIPWNLSLTLIGFYLGTNKSFILKFDYVISALTFIIGIYYLIKYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABS2</accession>
    <name>L0ABS2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="4">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232474.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0836"/>
    <dbReference type="EnsemblBacteria" id="AFZ70577">
        <property type="protein sequence ID" value="AFZ70577"/>
        <property type="gene ID" value="Calag_0836"/>
    </dbReference>
    <dbReference type="GeneID" id="14212096"/>
    <dbReference type="KEGG" id="clg:Calag_0836"/>
    <dbReference type="eggNOG" id="arCOG01998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_1_2"/>
    <dbReference type="OMA" id="PGPYGCL"/>
    <dbReference type="OrthoDB" id="7134at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="6">
        <location>
            <begin position="198"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="7">
        <location>
            <begin position="397"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="572" mass="62901" checksum="244236B8434320C2" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC00</accession>
    <name>L0AC00_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Valine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_1242</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232856.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1242"/>
    <dbReference type="EnsemblBacteria" id="AFZ70959">
        <property type="protein sequence ID" value="AFZ70959"/>
        <property type="gene ID" value="Calag_1242"/>
    </dbReference>
    <dbReference type="GeneID" id="14212502"/>
    <dbReference type="KEGG" id="clg:Calag_1242"/>
    <dbReference type="eggNOG" id="arCOG00808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_2"/>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="OrthoDB" id="4914at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="622"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="811" mass="95620" checksum="AAC357DC75ADB9B3" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC03</accession>
    <name>L0AC03_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major Facilitator Superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232472.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0834"/>
    <dbReference type="EnsemblBacteria" id="AFZ70575">
        <property type="protein sequence ID" value="AFZ70575"/>
        <property type="gene ID" value="Calag_0834"/>
    </dbReference>
    <dbReference type="GeneID" id="14212094"/>
    <dbReference type="KEGG" id="clg:Calag_0834"/>
    <dbReference type="eggNOG" id="arCOG00132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025894_0_2_2"/>
    <dbReference type="OMA" id="IPYLNLY"/>
    <dbReference type="OrthoDB" id="32618at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="143"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="361" mass="40130" checksum="D7E5950425BB07F4" modified="2013-03-06" version="1">MKKDEILLISSMAINGIIFGSSQLVNPLYLNELGLNSAQIGFLITGQMLIGSFLSLVYASLGDAYGRKKLAIINRGISIFGYFLLFLRFPFGLLIISVMSGGGLISALMAEKSQNLEKNYSLSYSLNTFLSIFGAMLPLFIRLRLVILFNLFILLTSTILISFVKEEYKGSGRVDFRLKSIKNVLKFSIESFVGLGAGLILPIISLWFYLKFGMTASQMSPIFAISNGVLAVSTLFSPKISQYFGKVKSIVYTHIIGIVLLILLPFSKNFYQASIIFIVRNSFMNMTGPIFSSFVMKLIPSEERARAQSLINFLDSIPRSVGPSIGGYFFYLGYLNLPFFITSVLYSIATAGFYILFKDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC12</accession>
    <name>L0AC12_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232866.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1252"/>
    <dbReference type="EnsemblBacteria" id="AFZ70969">
        <property type="protein sequence ID" value="AFZ70969"/>
        <property type="gene ID" value="Calag_1252"/>
    </dbReference>
    <dbReference type="GeneID" id="14212512"/>
    <dbReference type="KEGG" id="clg:Calag_1252"/>
    <dbReference type="eggNOG" id="arCOG01808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_926226_0_0_2"/>
    <dbReference type="OMA" id="HYYISSI"/>
    <dbReference type="OrthoDB" id="136264at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="300" mass="33370" checksum="C76E3E2130B6044D" modified="2013-03-06" version="1">MRTVGPPKSLKYLIIMPITGLLSLLIFYYLFKMAFPTQFPEFTSFSGIPVPSNLITIVYIDVFFIFLLLPYALYSRKYSNYMLELKRQARSFLEIYPSIASSLPSVSQAILASVELVEPPLRDYLAAFGSLYKMTGDLEGSFMKIFSSSPRDVRLLLTSILTTAKSGGRASDILNITSRYAAELQRMEFYLRNRLQSYSSVIFLGIAVYGFSVGMTIVMLEVLKRNATFGLSGVATQAINIAGILGIFFYSLLIVSAASSYIIAKVISDFAPRSSEYFIYLISIGTMTMAIALSLAIHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC27</accession>
    <name>L0AC27_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232574.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0949"/>
    <dbReference type="EnsemblBacteria" id="AFZ70677">
        <property type="protein sequence ID" value="AFZ70677"/>
        <property type="gene ID" value="Calag_0949"/>
    </dbReference>
    <dbReference type="GeneID" id="14212209"/>
    <dbReference type="KEGG" id="clg:Calag_0949"/>
    <dbReference type="eggNOG" id="arCOG01377">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024306_0_0_2"/>
    <dbReference type="OMA" id="HPRIHEM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="489" mass="57056" checksum="DD2A29BCEB7451F9" modified="2013-03-06" version="1">MKVLVLGLDGLSPQILKNALKKVDLPNLEKIIKKGETHSLLSIPPVTPIEWTSIATGVNPAKHGIWGFTKLIKIIDERKDANEKSYKKITAKWRYYTSKDVRFPRFFEISSFKRKNTLVINYPLTWPIEGNWNTANSDIISDTLISPRVETNRDDLKKFLKYFDPGLNPYDKTISYIKGFEKIIEEKSYELYTIILPFPDQAFHKDPDEVLNIRKRSRNIWEEIDSLLAFFLNFDNIFIVSDHGLAAYRKYANPLVPILYGNGYEKNMFTIAYTIVDKLSLYLKIPFRLIIKKTLIRKYFNFLRYRNELYKLNQIEAFTGYESEIEKIGFSHDMHDPADVWTTYFLNDEIRDEIIKIIKNDEVSKYVDIKKCEELFNGIYFPDFPSALFIPKFFNDTYLDFSRYPFSLSRLRLDLRTNHHIYGTFIAYGRGIKEKGKINLSSPLTNYDVSPTVLSSLGLQIPRGIDGKGIIEPIGNPFPYDIAMRIKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC53</accession>
    <name>L0AC53_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde:ferredoxin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232911.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1301"/>
    <dbReference type="EnsemblBacteria" id="AFZ71014">
        <property type="protein sequence ID" value="AFZ71014"/>
        <property type="gene ID" value="Calag_1301"/>
    </dbReference>
    <dbReference type="GeneID" id="14212561"/>
    <dbReference type="KEGG" id="clg:Calag_1301"/>
    <dbReference type="eggNOG" id="arCOG05072">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_440510_0_0_2"/>
    <dbReference type="OMA" id="CRFHRGW"/>
    <dbReference type="OrthoDB" id="5023at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="648" mass="73606" checksum="BBA87872E8C0C955" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACB0</accession>
    <name>L0ACB0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232961.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1355"/>
    <dbReference type="EnsemblBacteria" id="AFZ71064">
        <property type="protein sequence ID" value="AFZ71064"/>
        <property type="gene ID" value="Calag_1355"/>
    </dbReference>
    <dbReference type="GeneID" id="14212615"/>
    <dbReference type="KEGG" id="clg:Calag_1355"/>
    <dbReference type="eggNOG" id="arCOG01830">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003329_0_0_2"/>
    <dbReference type="OMA" id="CEHETRY"/>
    <dbReference type="OrthoDB" id="121889at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="285" mass="33835" checksum="5D74FF7306F735B0" modified="2013-03-06" version="1">MFEGWHIKTKHNNKEIIWIIKGYEHPKEGFISIPYRISGKRVNINEIYEEIKDYYLYLDCVGKEVPVVKRNEILKYYDPKEIFIKNVNILPKNIIELVEFLKVEYAGLVGSYLLGYQKKNSDVDLILYGNNNEIYENLLQMKREGLIFNCIDRYDKVSDTMTRSEYELFAQRRVLDSCYKGIPYTIRILRQIYSEECRSIYKTLKSFKGEIEIYDNKENFLVPSIYLANSIDLGKVEIMTWHTRYMELPLGRYYIEGVVQLNVKDNRLIVVPDQGGRIDPIEIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACB3</accession>
    <name>L0ACB3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0944"/>
    <dbReference type="EnsemblBacteria" id="AFZ70675">
        <property type="protein sequence ID" value="AFZ70675"/>
        <property type="gene ID" value="Calag_0944"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0944"/>
    <dbReference type="eggNOG" id="arCOG01367">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_2_1_2"/>
    <dbReference type="OMA" id="AGETTWH"/>
    <dbReference type="OrthoDB" id="43377at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="1">
        <location>
            <begin position="3"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="300" mass="34138" checksum="169628969FFA3DAF" modified="2013-03-06" version="1">MVMKLLITGITSLPGYKTVIEGIEKNHEIVGIYHEKIPDLKIKLIKADLTNKMLTQDIIIKEKPDAIIHIAGMGDVDNCEVEKEKCFNSNYLSTLNIVKVSNAFNIHMIYLSTDYVFDGQKGNYKENETPNPINYYGLTKLLGESSVKTLTNYAIVRTSTIYGIGIGRSNFAMYLINKLKNGEEIKAVVDQFTSPTNTTLLAKALIEIAEKRLIGVFHVGGERLSRYEFAVKLAEKMGFDTDLIRKTYINEMKWKAKRPIDSSLNFDNTKKFIDINFYETENALNILKSEYYSLKVEKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACE8</accession>
    <name>L0ACE8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl5</name>
        <name evidence="8" type="ordered locus">Calag_1380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232986.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1380"/>
    <dbReference type="EnsemblBacteria" id="AFZ71089">
        <property type="protein sequence ID" value="AFZ71089"/>
        <property type="gene ID" value="Calag_1380"/>
    </dbReference>
    <dbReference type="GeneID" id="14212640"/>
    <dbReference type="KEGG" id="clg:Calag_1380"/>
    <dbReference type="eggNOG" id="arCOG04092">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_2"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="OrthoDB" id="97230at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_A">
        <property type="entry name" value="Ribosomal_L5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022804">
        <property type="entry name" value="Ribosomal_L5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="6">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="7">
        <location>
            <begin position="78"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="186" mass="20835" checksum="2132B97D0BE3A48F" modified="2013-03-06" version="1">MSIALSEDEVNKILKSWEENPMTKPRITKVTVNIALGQGGEKLVKVQELLTQLTGQKASLRAAKKTVRAFGVRKGENIATMVTLRREKAYAFLKKALEAVGYRIKKSSIDKFGNVGFGITEYILLPGARYDPEIGIVGMDVIITVEKPGYRIEKRKIKTSDLPLRHRVKPEETMVLLSKEFGVTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACG0</accession>
    <name>L0ACG0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-grasp superfamily enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232724.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1105"/>
    <dbReference type="EnsemblBacteria" id="AFZ70827">
        <property type="protein sequence ID" value="AFZ70827"/>
        <property type="gene ID" value="Calag_1105"/>
    </dbReference>
    <dbReference type="GeneID" id="14212365"/>
    <dbReference type="KEGG" id="clg:Calag_1105"/>
    <dbReference type="eggNOG" id="arCOG00347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075000_0_1_2"/>
    <dbReference type="OMA" id="MPVRIYE"/>
    <dbReference type="OrthoDB" id="115684at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="257" mass="28213" checksum="BF6A0A635479330E" modified="2013-03-06" version="1">MNYSLEEILGYQFIEYGDLGKPKYLILGLPDAGIVGPIAASHIVTSLKLPDVLGIESYGYIPPAAIIQGNSIKYPMRIYSNNEVSVLITDVPPVPSGIVPLASAIVEFARKRGIEYIISISGVGNPSRAEIDKPNVYYLTTTQETQKLIEPFLNDLKPFPDGIIVGPYAIILKESVRRKVNNLLLLSDTFTDIPDPEAAAEIVKIISSIINVNIDVSPLIREAETLRLRLQGLAKETNDVLAKVGKGYEYRTPLIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACG3</accession>
    <name>L0ACG3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232637.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1018"/>
    <dbReference type="EnsemblBacteria" id="AFZ70740">
        <property type="protein sequence ID" value="AFZ70740"/>
        <property type="gene ID" value="Calag_1018"/>
    </dbReference>
    <dbReference type="GeneID" id="14212278"/>
    <dbReference type="KEGG" id="clg:Calag_1018"/>
    <dbReference type="eggNOG" id="arCOG01260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_2"/>
    <dbReference type="OMA" id="GICEFKE"/>
    <dbReference type="OrthoDB" id="67908at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="252" mass="27645" checksum="4116F1A508DF5221" modified="2013-03-06" version="1">MRVIVTASTKGIGYGISKVLLENGNEVVISGHNGENLANALNNLKNYGKVYGIISDLRNINDVRNLIDKSVNILKGLDAVVYVAPPPKPGNFESTPIEMWDDAVKSLLLSAVWVTKFSLPYIKESKGSYVYLSSFAIKEPQENLILSNVVRISLAGLTRSLSKELGKYGIKVNMIMPGWIETERVEEVVNSRAKSEGKSSEDIKKEIEKGIPLKRMAKPEEIGELVNFLIAKNTYISGASIPFDGGLLNSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACI1</accession>
    <name>L0ACI1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Flap endonuclease 1</fullName>
            <shortName evidence="10">FEN-1</shortName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fen</name>
        <name evidence="14" type="ordered locus">Calag_1412</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1412"/>
    <dbReference type="EnsemblBacteria" id="AFZ71119">
        <property type="protein sequence ID" value="AFZ71119"/>
        <property type="gene ID" value="Calag_1412"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1412"/>
    <dbReference type="eggNOG" id="arCOG04050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032444_0_0_2"/>
    <dbReference type="OMA" id="GSQDYDS"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019973">
        <property type="entry name" value="Flap_structure-sp_endonuc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="PTHR11081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03674">
        <property type="entry name" value="fen_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 10 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPGN" evidence="13">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="XPGI" evidence="12">
        <location>
            <begin position="146"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with PCNA" evidence="10">
        <location>
            <begin position="343"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ71119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="351" mass="40288" checksum="880CA5C7C21013F2" modified="2013-03-06" version="1">MKILGVNLKDLIPEKAKQEIDLKALKGYTVALDGYNMLYQFLAAIRQPDGTPLIDSKGNITSHISGLFYRTINLIEEGVKPIYVFDGKPPEMKKKEIEDRINRRQQYAEKYQKAKQEGKIEEAKKYAQASTSLSNKMVEDAKQLLTYMGIPWVQAPADGEAQAAYMAKKGDVYATGSQDYDSLLFGSPKLLRNLAITGKRKLPNKEEYIEIKPELINLNDMLKALEITREQLIVIGILLGTDFNPDGFKGYGPKTALKYVKEHRDPIKALSSLKVNDEDIDIMKIYEYFLNPPSNPNYKIEWRDPNEEKIIDMLVREHDFNDDRVKKALERLKKSFKESVKSKQARLDNWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACJ6</accession>
    <name>L0ACJ6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232677.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1058"/>
    <dbReference type="EnsemblBacteria" id="AFZ70780">
        <property type="protein sequence ID" value="AFZ70780"/>
        <property type="gene ID" value="Calag_1058"/>
    </dbReference>
    <dbReference type="GeneID" id="14212318"/>
    <dbReference type="KEGG" id="clg:Calag_1058"/>
    <dbReference type="eggNOG" id="arCOG02836">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194986_0_0_2"/>
    <dbReference type="OMA" id="RIKYTTV"/>
    <dbReference type="OrthoDB" id="130741at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="79" mass="9058" checksum="C4E5822DEA11C5E9" modified="2013-03-06" version="1">MKQRVGEQSSKYTTVSIPITLYDRIKNLINGTGFTSVSQFVIYVLRDVVASMEQEKVSSNISEEEKKEIIERLKKLGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACM0</accession>
    <name>L0ACM0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232702.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1083"/>
    <dbReference type="EnsemblBacteria" id="AFZ70805">
        <property type="protein sequence ID" value="AFZ70805"/>
        <property type="gene ID" value="Calag_1083"/>
    </dbReference>
    <dbReference type="GeneID" id="14212343"/>
    <dbReference type="KEGG" id="clg:Calag_1083"/>
    <dbReference type="eggNOG" id="arCOG05497">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056884_0_0_2"/>
    <dbReference type="OMA" id="SFWNGPE"/>
    <dbReference type="OrthoDB" id="17618at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="234"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="416" mass="47926" checksum="407241A0967B1121" modified="2013-03-06" version="1">MEFNFFPVMYQTSNSKGQELVAQRMLKWAIKLGYKSYLITSIYHDNEPIIRERDLELSEKPYKIFDRDPKIDLPTIRVLSRKVNWPPRRITFRDFITTLNKIDEEIGINFIVTHSTLWNGPEDTAKWILWRKLMGSIGVQEKKIIYAHMSHYQPPEPGRYDPIERTYRIAWNMTELPSIFKAADLILVVTGIEGEDMITQGANPKQIYIFPGGLDDDEAKKIDDAKPDLFLEQFVKKKLDRKIITYLGTIEERKNPLAVVEIAKHFKNNNDLLFVIAGKPGDQWDKVYKESKKLENVILTGELSVDQKASLIKASYLNIIMSKMEALGLTQIEFMYGGVPVITSAVYGQKWLITNGVEGIHLRGPDDIKGGVEAINKITENESLYMEMREKAREKGKSFLMSKLMKDLLEKAKQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACS3</accession>
    <name>L0ACS3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232752.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1133"/>
    <dbReference type="EnsemblBacteria" id="AFZ70855">
        <property type="protein sequence ID" value="AFZ70855"/>
        <property type="gene ID" value="Calag_1133"/>
    </dbReference>
    <dbReference type="GeneID" id="14212393"/>
    <dbReference type="KEGG" id="clg:Calag_1133"/>
    <dbReference type="eggNOG" id="arCOG01994">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1393521_0_0_2"/>
    <dbReference type="OMA" id="KTAIITW"/>
    <dbReference type="OrthoDB" id="120839at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="195" mass="21143" checksum="65356EF208CDB30E" modified="2013-03-06" version="1">MGIIDDAVDLMINEKSLRRTWITLIALFGIVGIIIILSYNAIMQSFVGQYLQSQESGIRQIAQSFGLGNSYYLLPFIIFGNNVKTAIITWVSSLTIVIPILIVAVNGGLVGFVLPGAYPNPPLVLFYLLVPHGVIEIPSVTLVSSVFILLISKGPVKMYKNSIGLLLISAIMLAVAAFIESFLTRTIAEIVASML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACV3</accession>
    <name>L0ACV3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L10e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl10e</name>
        <name evidence="6" type="ordered locus">Calag_1164</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232782.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1164"/>
    <dbReference type="EnsemblBacteria" id="AFZ70885">
        <property type="protein sequence ID" value="AFZ70885"/>
        <property type="gene ID" value="Calag_1164"/>
    </dbReference>
    <dbReference type="GeneID" id="14212424"/>
    <dbReference type="KEGG" id="clg:Calag_1164"/>
    <dbReference type="eggNOG" id="arCOG04113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084051_0_2_2"/>
    <dbReference type="OMA" id="HHVIREN"/>
    <dbReference type="OrthoDB" id="82104at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00448">
        <property type="entry name" value="Ribosomal_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_L10e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022981">
        <property type="entry name" value="Ribosomal_L10e_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="PTHR11726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="5">
        <location>
            <begin position="14"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="173" mass="19649" checksum="B3AF825D2B861AE6" modified="2013-03-06" version="1">MPMRPGRCYSHITSQPYTRKEYIHGAPPPKITKFEVGNKDMLKNYEIKVDLISLELGQIRSNALEAARVMTSKYLSTEVGDANYYMRIPKYPHQVIRENKMMAFAGADRLQDGMRLSFGTPIGVAAIVHAGDKLIEVWGRKADLEKIKEALRRGASKLPQKTRIVISEDRTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACW2</accession>
    <name>L0ACW2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sua5/YciO/YrdC/YwlC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232879.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1266"/>
    <dbReference type="EnsemblBacteria" id="AFZ70982">
        <property type="protein sequence ID" value="AFZ70982"/>
        <property type="gene ID" value="Calag_1266"/>
    </dbReference>
    <dbReference type="GeneID" id="14212526"/>
    <dbReference type="KEGG" id="clg:Calag_1266"/>
    <dbReference type="eggNOG" id="arCOG01952">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_3_1_2"/>
    <dbReference type="OMA" id="MLYPTDT"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="208" mass="22922" checksum="141435DA124B01A7" modified="2013-03-06" version="1">MIIKINIDCPDKEAIKEVAKVIKNGGVVVIPTDTVYGLTADPFNEKAMRKVYEVKGREEGKPLPILLGESHDAFSLVKPSETFWKLARAFWPGSLTIVENLSEKVPSHLSIWGSIGVRLPNCYFCRALAREVGGAIIGTSANISHMKSPVNVEEAYNMLKDKVDLYVDGGQARIGISSTVVSIINKEIKILREGAIKEEDIKRVLESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACW3</accession>
    <name>L0ACW3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein, putative amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233166.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1571"/>
    <dbReference type="EnsemblBacteria" id="AFZ71269">
        <property type="protein sequence ID" value="AFZ71269"/>
        <property type="gene ID" value="Calag_1571"/>
    </dbReference>
    <dbReference type="GeneID" id="14212833"/>
    <dbReference type="KEGG" id="clg:Calag_1571"/>
    <dbReference type="eggNOG" id="arCOG04536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1173330_0_0_2"/>
    <dbReference type="OMA" id="REWINNK"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ71269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="236" mass="26440" checksum="9707F97412019AC4" modified="2013-03-06" version="1">MQNKNNCIDYKYISSSKVKELNNFIFIIPIGSIEQHCDAPMGLDSLIAERIAYGLCGVMENIVVMPTIYYGFSPEWNNVDGTISLNIETFSGFIKSILDSLNKINAKRIVFLNGHGGNSYILEAVLREWINNKTNTIILLNYWKALGINVGHSGSIERSIARALGIQFEESNCNGIIDFYNGASKIIINGPMIGSKTYEKDKIEITQEEILLKIKNEIINGINFAEKIKSNSMFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD48</accession>
    <name>L0AD48_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit beta</fullName>
            <ecNumber evidence="6">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">psmB</name>
        <name evidence="8" type="ordered locus">Calag_1353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1353"/>
    <dbReference type="EnsemblBacteria" id="AFZ71062">
        <property type="protein sequence ID" value="AFZ71062"/>
        <property type="gene ID" value="Calag_1353"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1353"/>
    <dbReference type="eggNOG" id="arCOG00970">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_2_2"/>
    <dbReference type="OMA" id="VDKTGPH"/>
    <dbReference type="OrthoDB" id="89767at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03634">
        <property type="entry name" value="arc_protsome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="4 6 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="5 6" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005069289" description="Removed in mature form; by autocatalysis" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023424271" description="Proteasome subunit beta" evidence="6">
        <location>
            <begin position="16"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6 7">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="210" mass="22754" checksum="D2E0179CCD19CEF6" modified="2013-03-06" version="1">MILFDKENSLKAFHGTTTVGFITKNAVILAADKRATAGTLIASRTVKKIVKITDYAAMTIAGLVADAQMLADAIREEARLYETMNKRKLTVKGMATLLANVLFSTKYYPYLVQLIVGGYDTEPRLYNLDYFGSITEEKMTSTGSGSPVALGVLEKDYRPDLSLEEAMNLAAKAIKVAIMRDSATGDGVDVIAISSGGIRESFIPLQQLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD49</accession>
    <name>L0AD49_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative adenylate kinase</fullName>
            <shortName evidence="2">AK</shortName>
            <ecNumber evidence="2">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1259"/>
    <dbReference type="EnsemblBacteria" id="AFZ70975">
        <property type="protein sequence ID" value="AFZ70975"/>
        <property type="gene ID" value="Calag_1259"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1259"/>
    <dbReference type="eggNOG" id="arCOG01038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079096_0_0_2"/>
    <dbReference type="OMA" id="QCEIFGT"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="PTHR12595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMP" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="2">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="203" mass="23391" checksum="679BA48152A1ABA4" modified="2013-03-06" version="1">MNEEGFIFISGTPGTGKSTLAKLISEELNCNYIEVSDFAVKKNLVIPDETGRDTYVIKEDELKEEILKEKGKGLTILVTHYPDVFLDDDRFYLNTLFLILLRTNPKILMDRLNKKGWDEKKVKENVLAEAFNTIAEDIYDYKDIVIEIDTSNENPNNLLDIVFNKINTLDFGIRINWLLNETLIDFISSLVDDVNFNNDRISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD91</accession>
    <name>L0AD91_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232917.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1308"/>
    <dbReference type="EnsemblBacteria" id="AFZ71020">
        <property type="protein sequence ID" value="AFZ71020"/>
        <property type="gene ID" value="Calag_1308"/>
    </dbReference>
    <dbReference type="GeneID" id="14212568"/>
    <dbReference type="KEGG" id="clg:Calag_1308"/>
    <dbReference type="HOGENOM" id="CLU_1912242_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="132" mass="16109" checksum="A83B5F27D8786E81" modified="2013-03-06" version="1">MSISEQYYNYIWECVRNGLKNDGIISLKHYNRLLDNFFKNYKGFFDIPLYLRFYLIVQAFIYTTLDQIIDILMEEDDLKSLEGYFKELLKLLNELRRDIMQEAKEYNVYDKNYEKTLILVDILKSFVERLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADA4</accession>
    <name>L0ADA4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232989.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1383"/>
    <dbReference type="EnsemblBacteria" id="AFZ71092">
        <property type="protein sequence ID" value="AFZ71092"/>
        <property type="gene ID" value="Calag_1383"/>
    </dbReference>
    <dbReference type="GeneID" id="14212643"/>
    <dbReference type="KEGG" id="clg:Calag_1383"/>
    <dbReference type="eggNOG" id="arCOG13708">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703222_0_0_2"/>
    <dbReference type="OMA" id="FPAIANN"/>
    <dbReference type="OrthoDB" id="142074at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="391" mass="45753" checksum="DBA4E20F4B612969" modified="2013-03-06" version="1" precursor="true">MENKRLFEEWFSLYKIFIENNKFSNKVLSIPTFPAIANNNKIYDIDLDMGIKLSWNCCNSYKLNLNGGGLISEIPSKPMETLSFDYNEFIPQSIINSDYKINPLGWNPINPIDKELDYGECFQYNNKKIYVRSSEPFKFIKKQNCVELKHNENKPTFRVGYLEFNVKNRFSFATRNLYETDMGILFNNKNVTYVFDHEKEMFFKIPLYDFKYYILYPFRFFKFHAYDKKCFKANVFVLDSENPIGIVSRYGIGIEISPGELRIKTDKPFYIVNAGPILSFRSLIETLVDFPYGYEIMNHVRSGSSAIILSGIYDEFIEFEIFNATNNDSIIEMIPKIKTDKIEICSHLGCYDIIESKGIYRIPAPSGCYCNARLHIIKESTIKNKLLRLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADF3</accession>
    <name>L0ADF3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S19P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps19p</name>
        <name evidence="8" type="ordered locus">Calag_1371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1371"/>
    <dbReference type="EnsemblBacteria" id="AFZ71080">
        <property type="protein sequence ID" value="AFZ71080"/>
        <property type="gene ID" value="Calag_1371"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1371"/>
    <dbReference type="eggNOG" id="arCOG04099">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097347_1_0_2"/>
    <dbReference type="OMA" id="VIRTHCR"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_S19A/S15e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="148" mass="16882" checksum="29D5AA3B5591178F" modified="2013-03-06" version="1">MKGMSIELKPEWKRFKYRGKTLEELLNMPMDELVKLFPSRSRRSLARGFTPSQKILLSKIRALRKIMQQDPSKENVVIKTHVRDLVILPEMIGLTIAVYNGKEFVPVKIIPEMIGHRLGEYSHTTKTVHHGEPGLKASKSSLHVAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADN5</accession>
    <name>L0ADN5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase-like amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233144.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1549"/>
    <dbReference type="EnsemblBacteria" id="AFZ71247">
        <property type="protein sequence ID" value="AFZ71247"/>
        <property type="gene ID" value="Calag_1549"/>
    </dbReference>
    <dbReference type="GeneID" id="14212811"/>
    <dbReference type="KEGG" id="clg:Calag_1549"/>
    <dbReference type="eggNOG" id="arCOG01943">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_8_4_2"/>
    <dbReference type="OMA" id="DFVDSWP"/>
    <dbReference type="OrthoDB" id="79386at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="175" mass="20287" checksum="3D341C889A3AAFC5" modified="2013-03-06" version="1">MRPALIIIDMLNDFISGTLKTEEAISTVKPTKKAIDVFRRRKYPIFYVNDSHYNNDFEIPLWGPHAMKGTDGAKVYEEIKPEKDDFVLEKHAYSAFFQTPLDYLLRTNGIDTVFLAGLDADICVRHTAADAFFRGYKIYVIKDAVAARIDKNWEIYYKKVYNANIVYSEELEKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADX1</accession>
    <name>L0ADX1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aspS</name>
        <name evidence="8" type="ordered locus">Calag_1552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233147.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1552"/>
    <dbReference type="EnsemblBacteria" id="AFZ71250">
        <property type="protein sequence ID" value="AFZ71250"/>
        <property type="gene ID" value="Calag_1552"/>
    </dbReference>
    <dbReference type="GeneID" id="14212814"/>
    <dbReference type="KEGG" id="clg:Calag_1552"/>
    <dbReference type="eggNOG" id="arCOG00406">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_2"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="24288at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="PTHR43450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="145"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="6">
        <location>
            <begin position="194"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="224"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="412"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="441" mass="51450" checksum="6215BCA6D4A68B6F" modified="2013-03-06" version="1">MLKNNFIQDIYDQAQNYLNKDIKICGWVSNIRDLGGVKFVLLRDRTGILQLVFKKGITPDEEIMKSKDLVKESVICIDGVLTEGKSSLKYEVQVKKLNILNKPYEPIPLDPDTSTDAQINVRLDYRWLDVRNRKISSIFVFESWVAKNFRDYLTEKGFVEIFTPKIVSTGTEGGAEVFPVIYFGKEAYLAQSPQFYKQLAVISGLERVFEIGPVFRAEASHTVRHLAEFHGLDFEMGYINNVNDVMDTVEGFFRRMVEKSKKDELIKQVREFFSLDVSIPEKVPRIPIREAYKILEKYDKHLPYGSDLDTESERILGEYAKKEYNSDFVFVTEYPWKVRPFYTMRKEDDDQWTYGFDLLFRGLEVATGSQREHRYDMLIKNLKDKGLDDKKFKFYLDFFKDGTPPHGGVGLGLERIVKQFLNLDNVREARFLPRDTERITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7F3</accession>
    <name>L0A7F3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0215 protein Calag_0002</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0215 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231696.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0002"/>
    <dbReference type="EnsemblBacteria" id="AFZ69798">
        <property type="protein sequence ID" value="AFZ69798"/>
        <property type="gene ID" value="Calag_0002"/>
    </dbReference>
    <dbReference type="GeneID" id="14211264"/>
    <dbReference type="KEGG" id="clg:Calag_0002"/>
    <dbReference type="eggNOG" id="arCOG00928">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095956_1_1_2"/>
    <dbReference type="OMA" id="GFNYIIP"/>
    <dbReference type="OrthoDB" id="103162at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00582">
        <property type="entry name" value="UPF0215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002802">
        <property type="entry name" value="DUF99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39518">
        <property type="entry name" value="PTHR39518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01949">
        <property type="entry name" value="DUF99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006380">
        <property type="entry name" value="UCP006380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="189" mass="21380" checksum="F919DCC31DACB6F4" modified="2013-03-06" version="1">MIIEKIIACDDGEVKKLGYGKTLVSCISYKEVWPENIKIGFVHTDGLDATSVLSYLIKTLANNEKSVVLFDSITIAGFNVISLPGIQKLTNLPSIVIYNYKPSIKNLLKALRPHFEDSYIRELALNQLKEIKKIETNRGVLYIVNRGVNKEEAIQLINSYQFYSTIPEPLRMSHIISSHLSKIINPYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7L4</accession>
    <name>L0A7L4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nac</name>
        <name evidence="6" type="ordered locus">Calag_0015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Contacts the emerging nascent chain on the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Interacts with the ribosome. Binds ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0015"/>
    <dbReference type="EnsemblBacteria" id="AFZ69811">
        <property type="protein sequence ID" value="AFZ69811"/>
        <property type="gene ID" value="Calag_0015"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0015"/>
    <dbReference type="eggNOG" id="arCOG04061">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146475_0_0_2"/>
    <dbReference type="OMA" id="PRKMKQM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00814">
        <property type="entry name" value="NAC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005231">
        <property type="entry name" value="NAC_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="HYPK_UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00264">
        <property type="entry name" value="TIGR00264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="5">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="117" mass="13046" checksum="0754DE9FECCD6BB6" modified="2013-03-06" version="1">MMGMNPKDLKKAMKRLGMEIEEVKAEKVTIDETDGSKLIIEDPQVMIIKAKNQPTMVYVVGEPKKVEETKKKEEVSISEEDINLVMEQANVDKETAKKALIESNGDIAEAILKLKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7Q2</accession>
    <name>L0A7Q2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="2">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231796.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0110"/>
    <dbReference type="EnsemblBacteria" id="AFZ69898">
        <property type="protein sequence ID" value="AFZ69898"/>
        <property type="gene ID" value="Calag_0110"/>
    </dbReference>
    <dbReference type="GeneID" id="14211370"/>
    <dbReference type="KEGG" id="clg:Calag_0110"/>
    <dbReference type="eggNOG" id="arCOG01033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_4_1_2"/>
    <dbReference type="OMA" id="FGNPIKH"/>
    <dbReference type="OrthoDB" id="98644at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="3">
        <location>
            <begin position="103"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ69898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="248" mass="28560" checksum="AF8D43044EE424A6" modified="2013-03-06" version="1">MSKLKLGLVGENISKSPSPLIHNYIYKNYDIDASYNLYEIKREEFDKKINDIINQNYGLNITMPYKENVIKFLRGLSDKVEKIKAVNTIKENIGYNTDYLAFKNILSNYEIKNALVLGAGGAARAAIHAIIELNVENLYIFNRTQERALNIIRELNKISNINVKLIKDISSVKSDLIVNTVPIDLNLNTTKIYIDLVYLRKPKEIAPIIIDGYNFLIEQALLSDEIWFNIKFDEEVKKDLRKLIGKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7S1</accession>
    <name>L0A7S1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0087"/>
    <dbReference type="EnsemblBacteria" id="AFZ69876">
        <property type="protein sequence ID" value="AFZ69876"/>
        <property type="gene ID" value="Calag_0087"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0087"/>
    <dbReference type="eggNOG" id="arCOG00239">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_3_2"/>
    <dbReference type="OMA" id="RPPRFTW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="250" mass="27493" checksum="311A2129A0040C21" modified="2013-03-06" version="1">MMYIKTVDEDVLSWIIIDRENKANSLNYDTLKELKEAICKQCERNDISAIAIIGAGEKFFSGGTDLNDVLDATSDINKAWKLMYEGLGGVIRGALNCKLPVIAAINGYALGAGFELIHTSDIAYAVKTAKIGLPAVKWGMIPPYSSTLGHLFVNSKLLSYLALTGDMITAEEAFKYGLINGVVDDINSLKAKVIEVARKISSNDKIAVRQIKQLMARKKVDDLLDLGFSVMSSIIPREEVKKKVEEFVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7T0</accession>
    <name>L0A7T0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231784.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0098"/>
    <dbReference type="EnsemblBacteria" id="AFZ69886">
        <property type="protein sequence ID" value="AFZ69886"/>
        <property type="gene ID" value="Calag_0098"/>
    </dbReference>
    <dbReference type="GeneID" id="14211358"/>
    <dbReference type="KEGG" id="clg:Calag_0098"/>
    <dbReference type="eggNOG" id="arCOG04100">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016513_2_1_2"/>
    <dbReference type="OMA" id="IEYHPAY"/>
    <dbReference type="OrthoDB" id="11292at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="8">
        <location>
            <begin position="14"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="161"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="271"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ69886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="545" mass="62369" checksum="DCA387401C7DCEDF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7T9</accession>
    <name>L0A7T9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0108"/>
    <dbReference type="EnsemblBacteria" id="AFZ69896">
        <property type="protein sequence ID" value="AFZ69896"/>
        <property type="gene ID" value="Calag_0108"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0108"/>
    <dbReference type="eggNOG" id="arCOG01049">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062599_1_1_2"/>
    <dbReference type="OMA" id="FRGIPTM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="266" mass="29156" checksum="0B76416F07486A40" modified="2013-03-06" version="1">MMSYKLVSKNYKEKTLVKVGNVIIGDKPVIIAGPCAVENREQIIKTALFVKENGAKILRGGAFKPRTSPYSFQGLGEEGLKLLREASEEAKIPFVTEVMDVNTVRLVAAYADALQVGARNMQNFPLLKELGKIDKPVFLKRGFGNTIDELLQSAEYILAGGNDQVVLVERGIRTFESSTRFTLDIAAVPVLKNLTHLPVIVDPSHAAGKRIYVPPLAKAGIAVGSDGLMIEVHPEPDKALSDGPQQLTFEMFKQLMEDLRKIAVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7U3</accession>
    <name>L0A7U3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ69943">
        <property type="protein sequence ID" value="AFZ69943"/>
        <property type="gene ID" value="Calag_0157"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0157"/>
    <dbReference type="eggNOG" id="arCOG00138">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062161_0_0_2"/>
    <dbReference type="OMA" id="AWPLFPL"/>
    <dbReference type="OrthoDB" id="22281at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="380" mass="42303" checksum="7DF1411ADF6EC00F" modified="2013-03-06" version="1">MEINNKKAISKISIYNLINSMTSNAYSPFLSFIGATLGLPGYLLGLVSTSGTFFTNLSQYFSSLTKKSPKSLIFYGNLIKSLSLFALFFLTSQGPLYTILISIIMIGSGISSFGFSLLTEFYSRASRSVTLSRIYFYSSLGSLPVIALGGLYLEVNTILVKYVFLIASIVTSISTFIVIGLDYKEDYRSKNSAWINNEDFNKLKKFFIFNLIYMITWSFAWPLFPLAQLYVFHMTTFQVGIINIIATSSTILLQRFFGYFIAKHTKLSLFIGRLTNTFFALAYAISPNVNGIYLANILGGVSNSINNVGYFAYLVDNSKDKRAAIGTYSVIMGISALAGGEIGGFTYDYLDQKYGYHILRSLFLYTAISRSVAASLFLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7Y1</accession>
    <name>L0A7Y1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="9">KARI</shortName>
            <ecNumber evidence="9">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="9">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ilvC</name>
        <name evidence="13" type="ordered locus">Calag_0155</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231839.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0155"/>
    <dbReference type="EnsemblBacteria" id="AFZ69941">
        <property type="protein sequence ID" value="AFZ69941"/>
        <property type="gene ID" value="Calag_0155"/>
    </dbReference>
    <dbReference type="GeneID" id="14211415"/>
    <dbReference type="KEGG" id="clg:Calag_0155"/>
    <dbReference type="eggNOG" id="arCOG04465">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033821_0_1_2"/>
    <dbReference type="OMA" id="RAMFSWL"/>
    <dbReference type="OrthoDB" id="25435at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="11">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="12">
        <location>
            <begin position="183"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="25"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ69941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="331" mass="36901" checksum="D3BB8CF1D61B7E94" modified="2013-03-06" version="1">MGKIYNDEESSLDFVKGKKIVVLGYGNQGRAWALNLRDSGLNVIVGLERKGNSWILAEKDGFEPKYINDAVKDADILIFLLPDMVQREVWEKSIMKNMKEGADMVFAHGFNIHYKLILPPKTSDVYMIAPKGPGNKVREYFEKGGGVPALIAVHQDISGNALNKALAIAKGIGATRPGVIETTFKEETETDLFGEQVILVGGISELMKNSFATLVSKGYQPEVAYFETINEMKMIVDLIYEKGLSGMLRAVSDTAKYGGITVGKDIIDEEVRKRMEKALTRIQNGEFANEWIEEYQRGMKTVKSNLNEVDNSLEEKIGKRLRDLILKGSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7Y5</accession>
    <name>L0A7Y5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0201"/>
    <dbReference type="EnsemblBacteria" id="AFZ69983">
        <property type="protein sequence ID" value="AFZ69983"/>
        <property type="gene ID" value="Calag_0201"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0201"/>
    <dbReference type="eggNOG" id="arCOG03841">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038930_0_1_2"/>
    <dbReference type="OMA" id="KICVEMG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="DUF917"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="DUF917_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="DUF917_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="DUF917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="363" mass="39966" checksum="2D6AD6689CE00799" modified="2013-03-06" version="1">MNNMLKLSNIEDAKKLVLGASFLATGGGGNPNQGLKMLSKALDHGPIEIIDVEDLPENTIIGVPYFVGSVSSKEKDFSEDIIIETVNTLESIVGKKISALAASEIGGGNTPIVFYIASRLGVPVIDGDFIGRAAPELDQSTANVMGYPLYPSVISTNDGDLVIVKKYANTSHYEHIARQISVAGDNSAFVIDTPLSSIETKKSIVRKTISLSIKIGEKIYEAKNKKLDPIDEVVKLTNGFKILRGEITDYHLEEKEGFLIGEVTVKGQFKNKEIIAKSWIKNEHILLKVNDKPAVFPPDLIIFARDDGTPLLNYEIEKGIVVNIVSIRAPEIWRTKKGLEIFGPRHFGFDYDYIPVEELINHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8E1</accession>
    <name>L0A8E1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0312"/>
    <dbReference type="EnsemblBacteria" id="AFZ70091">
        <property type="protein sequence ID" value="AFZ70091"/>
        <property type="gene ID" value="Calag_0312"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0312"/>
    <dbReference type="eggNOG" id="arCOG01389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_646559_0_0_2"/>
    <dbReference type="OMA" id="RNRWAEG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="435" mass="49001" checksum="8E87A94C4049FCA5" modified="2013-03-06" version="1">MKIMQVQYIDLNQIQTLLKVINVEYQSYLPKWAMIYIAATGTIASLLAAVELAIFVSPMNSTNKYNVDDLKKKLSYYPLVSIILPSYKEGDLLKRALKSINEQTYPHNKIEVILAVEKDDNTIDKALDIVGLSNCKENCCSSSMGDIKTKIVYGKGNGKPSALNEALKCVEGEIIGVLDADDILTKNAIITAVSYLVNQDIDAIQLPREVILDKESKKTFKGAHIRAQEAEMFLYTKLLAPVMEKLSGISWVMGSGYFVKKDVLNKLGGWEEKAATEDLDLSIRMIASGYKIKVISESPVYTEPVRNYSQLITQKERWVRGMLLLVPKVLRHPRKSWPLLSIYLMPIAEYATILWPIMAPYALKYAIIAFFIEFLIGFASYYTIYKRVGKTIRPLPIILAIYGITSWIALAKLVIGRAHEWKGTRLTKGIKVSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Q0</accession>
    <name>L0A8Q0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232146.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0482"/>
    <dbReference type="EnsemblBacteria" id="AFZ70248">
        <property type="protein sequence ID" value="AFZ70248"/>
        <property type="gene ID" value="Calag_0482"/>
    </dbReference>
    <dbReference type="GeneID" id="14211742"/>
    <dbReference type="KEGG" id="clg:Calag_0482"/>
    <dbReference type="eggNOG" id="arCOG00874">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008213_6_0_2"/>
    <dbReference type="OMA" id="IIVFTQY"/>
    <dbReference type="OrthoDB" id="14047at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="169"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="399"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="532" mass="61550" checksum="7C24465601D1C4CA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8S2</accession>
    <name>L0A8S2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aromatic ring hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231717.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0024"/>
    <dbReference type="EnsemblBacteria" id="AFZ69819">
        <property type="protein sequence ID" value="AFZ69819"/>
        <property type="gene ID" value="Calag_0024"/>
    </dbReference>
    <dbReference type="GeneID" id="14211285"/>
    <dbReference type="KEGG" id="clg:Calag_0024"/>
    <dbReference type="eggNOG" id="arCOG02143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023920_1_0_2"/>
    <dbReference type="OMA" id="GWDALNT"/>
    <dbReference type="OrthoDB" id="15213at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004925">
        <property type="entry name" value="HpaB/PvcC/4-BUDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024719">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024674">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36117">
        <property type="entry name" value="PTHR36117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03241">
        <property type="entry name" value="HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11794">
        <property type="entry name" value="HpaB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000331">
        <property type="entry name" value="HpaA_HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpaB_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="HpaB" evidence="1">
        <location>
            <begin position="285"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="485" mass="54150" checksum="406473572CA1CBAE" modified="2013-03-06" version="1">MLGTSNDYLNRLKEREKDIDIYVGGEKVEDVLNNPVIRPSINVITKTYELSLKNEYKGILTVMQDNEEINRLVYVEKSINDLIMRAESQRILNSHIGNCNYRCTGHDGINAVYASTYDIDSKLNTEYHKRFLRWLKDVQSKDLVVETAMTDVKGNRSKGPLEQKNDFAYVHVVERKKDGIIVRGAKMHITGAAIADEILVIPTKNMKQNERDYAVSFAIKPETKNVHFISSWHPMDIMKKVSKDLGTDIDYPLPFGHRNTYLIIFDDVFVPNDRVFMDGEYEFTGKLIEYFVSHHRAGGGPCKAGFADVILGSAALMADANGVLNASYIQDRLLDIMRHGESAYAAGLAAMVKGYRHPSGEYIPDFRLANITKLDSIEHLKEAIIASADIGGGITVNAPSSKDLNIEGLSNKIAEALKGNENYTAEERLRIARLLQLWVAGPHLVGLIQGGGPPAAELLALKNDMKNRLNDLIENAKIMAGIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8S7</accession>
    <name>L0A8S7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231722.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0031"/>
    <dbReference type="EnsemblBacteria" id="AFZ69824">
        <property type="protein sequence ID" value="AFZ69824"/>
        <property type="gene ID" value="Calag_0031"/>
    </dbReference>
    <dbReference type="GeneID" id="14211291"/>
    <dbReference type="KEGG" id="clg:Calag_0031"/>
    <dbReference type="eggNOG" id="arCOG04124">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155659_4_3_2"/>
    <dbReference type="OMA" id="RYYFFEL"/>
    <dbReference type="OrthoDB" id="127137at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="127" mass="15074" checksum="24299553E14CF90E" modified="2013-03-06" version="1">MRYYFFELLACPECKSDNLMLYELNVKEDKVDIDPEKIKCKEKCAFQKKPANEVPIDICKRCVNLDVIDGIIICKNCGRWYPIIDGIPRMLNDKYRKYHEDVELLRKYLDKIPLDIKNLMKIPELGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8U3</accession>
    <name>L0A8U3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">V-type ATP synthase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">V-ATPase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpD</name>
        <name evidence="8" type="ordered locus">Calag_0047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231737.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0047"/>
    <dbReference type="EnsemblBacteria" id="AFZ69839">
        <property type="protein sequence ID" value="AFZ69839"/>
        <property type="gene ID" value="Calag_0047"/>
    </dbReference>
    <dbReference type="GeneID" id="14211307"/>
    <dbReference type="KEGG" id="clg:Calag_0047"/>
    <dbReference type="eggNOG" id="arCOG04101">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069688_2_2_2"/>
    <dbReference type="OMA" id="WLSITHM"/>
    <dbReference type="OrthoDB" id="93236at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ69839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="223" mass="26198" checksum="0F6441FE3C715BC8" modified="2013-03-06" version="1">MSVDPRKTLPTKINLIRLKRDYAMIKRVRRIMEEKREVLLHYIRSTAEDYNKYQNEVFKNITDLFTMYYRGVASEGLSKVDLYASSIPESFTIKTGLRVLYSVRTPTFTPIMDTIAIPSLPPGSSPDLTISYIKLKELLPSILNLAMYEETILRLIDELKETQRLINALDYVILPSYLRTIKYINAVLDERMREDFVRLKILKRKRVEQEEKAKVVMEQQSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8X9</accession>
    <name>L0A8X9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps2</name>
        <name evidence="7" type="ordered locus">Calag_0556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232214.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0556"/>
    <dbReference type="EnsemblBacteria" id="AFZ70316">
        <property type="protein sequence ID" value="AFZ70316"/>
        <property type="gene ID" value="Calag_0556"/>
    </dbReference>
    <dbReference type="GeneID" id="14211816"/>
    <dbReference type="KEGG" id="clg:Calag_0556"/>
    <dbReference type="eggNOG" id="arCOG04245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058171_3_0_2"/>
    <dbReference type="OMA" id="QQKTKDM"/>
    <dbReference type="OrthoDB" id="63341at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_A">
        <property type="entry name" value="Ribosomal_S2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023454">
        <property type="entry name" value="Ribosomal_S2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_S2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="PTHR11489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="206" mass="23376" checksum="EC68ABB612A9BCA1" modified="2013-03-06" version="1">MSEEENKELLVSSDTYKKAGVIFGTQICTKYMRNFVYKILPDGFYLLDVNKIDERIRIAGRFLSTFDPKKIAVVSTRIYGQRPITIMCDKLGCKAISGRVIPGIFTNPKLDNYMEPDAIIITDTRTDRQALVEASKIGIPVVALADTDNKIEDVDFIIPANNKGRRSLALVYWLLTREIMRNKGLLAPGQEPDFTYEDFVTSRIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Y9</accession>
    <name>L0A8Y9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232251.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0596"/>
    <dbReference type="EnsemblBacteria" id="AFZ70353">
        <property type="protein sequence ID" value="AFZ70353"/>
        <property type="gene ID" value="Calag_0596"/>
    </dbReference>
    <dbReference type="GeneID" id="14211856"/>
    <dbReference type="KEGG" id="clg:Calag_0596"/>
    <dbReference type="eggNOG" id="arCOG01875">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107444_0_0_2"/>
    <dbReference type="OMA" id="IGIYVEK"/>
    <dbReference type="OrthoDB" id="76894at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023098">
        <property type="entry name" value="SerK/SbnI_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="215" mass="25340" checksum="DBC148174B464E5F" modified="2013-03-06" version="1">METKNLSSVNIGLVNISDLKQHEYALDEHIEELKQKIIMEKIIRKPIIADINTGTIIDGAHRTRALKSLNVKYIPAILIDYLNYNEMYVDKWIRIYYFDNQSEIITDLKSIFCFDNIEHNHKSTKIKLCDDNKIDAYMQINKFENEYKELIKGIYFSKSPLKQNKRNGIIIDPPKLDKNDVIYVALKQMLLPPRSTRHISLLKKIYINFSLKDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0A942</accession>
    <name>L0A942_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate kinase</fullName>
            <ecNumber evidence="3 11">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Calag_0631</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 11"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0631"/>
    <dbReference type="EnsemblBacteria" id="AFZ70386">
        <property type="protein sequence ID" value="AFZ70386"/>
        <property type="gene ID" value="Calag_0631"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0631"/>
    <dbReference type="eggNOG" id="arCOG04120">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_1_1_2"/>
    <dbReference type="OMA" id="QVPIVQK"/>
    <dbReference type="OrthoDB" id="40634at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="12">
        <location>
            <begin position="2"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="13">
        <location>
            <begin position="347"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ70386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="458" mass="50805" checksum="657B351ECBC3474D" modified="2013-03-06" version="1">MRLLKIVATVGPANYDYNVIRKMVASGTDAFRINMSHGDQKQWEDFIDLINKASNELGIKVTKIADLEGPRVRLGNFEPVKIQQGQNLVLRYENSKIDGIPVDNKVFFSSIEQGDKILIDDGKVSAEVEIVEKDSAEVRIIEGDLLEPRKGVVLAGKEFDMPPITDKDLNDMKFIAAKDFDYVMVSFVRNSKHIDIVREALKKQGANNIGLLAKIETPSGVKNIDEISEAADGIVVARGDLGMHFPLEQLPMIQKKIIESARRKLKPVILATEIFMSMIERPVPSRGEISDVYKAVEEGVDGFLVTSETSIGKYPVQVIIWLSRVIQEAQKHITPNRIEISDISDARIAKGVVDLANDIGAEIVSYATTIDMSRFIAGFRPSKPIYTGVSEESVAKKLNIFYGIKPLIVGQSNNEEEGLKVTESYLRKEGVLGAGDTVIETARSLEENSFIIKVKQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A959</accession>
    <name>L0A959_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0174"/>
    <dbReference type="EnsemblBacteria" id="AFZ69959">
        <property type="protein sequence ID" value="AFZ69959"/>
        <property type="gene ID" value="Calag_0174"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0174"/>
    <dbReference type="eggNOG" id="arCOG02688">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_6_2"/>
    <dbReference type="OMA" id="QIWIIWL"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="26"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="450" mass="50309" checksum="2A9EF8236676A768" modified="2013-03-06" version="1">MSVSQKRYSIAARLDRLPWTSLHTKLLMLLSLGEFFDLYDLFAGGFTVTPIHLYYHVGIESAIFYTIAIFFLGAFVGVILLGYIGDLLGRRTVIVINMIIMSIAYLLTPFSPNIYVLGALRFIAGLGAGPEAILVVDIMSTEFYPAAIRGNRLAIAYTIAWISPIIVALISLFTIPSHWQWIYWVGGIGILTIIPLRFMIPESPRWLEVHNKYDEADKIVSQFEQQAIKEGKKLPEPVEVEVIKTEKVPLSEAFKGVYLKRMVMLLIFQFFQAAVYYGFTSLAPTVLYSKGFTFAKSTTMTFVIYTGYFIGSLLSIFLIDKKVFDRKWQIVVYMTLAGVLGVLFGYSHSVILLETSGFLLATFLNLFSNTYHQYMAEILPTRVRAASDGLQYSLSRLGTFIFLTYLGSVLVTSGPTALYLTTFAFAIIVALDIAALGPKATGERIEVIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9E1</accession>
    <name>L0A9E1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0258"/>
    <dbReference type="EnsemblBacteria" id="AFZ70039">
        <property type="protein sequence ID" value="AFZ70039"/>
        <property type="gene ID" value="Calag_0258"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0258"/>
    <dbReference type="eggNOG" id="arCOG00731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153620_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="80" mass="9175" checksum="4376D07EF93F2A85" modified="2013-03-06" version="1">MRLKIIELILEKGPLNANQISKMLDVNYKTVIHHLNVLTENNLIISEGPRYGQIYSPSKFLIQNRNILDKVLCINGEKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9E2</accession>
    <name>L0A9E2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcription regulator containing HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232388.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0747"/>
    <dbReference type="EnsemblBacteria" id="AFZ70491">
        <property type="protein sequence ID" value="AFZ70491"/>
        <property type="gene ID" value="Calag_0747"/>
    </dbReference>
    <dbReference type="GeneID" id="14212007"/>
    <dbReference type="KEGG" id="clg:Calag_0747"/>
    <dbReference type="eggNOG" id="arCOG04189">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182708_0_0_2"/>
    <dbReference type="OMA" id="YGWLVFF"/>
    <dbReference type="OrthoDB" id="124010at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="99" mass="10915" checksum="0A2DCDA82B1F6239" modified="2013-03-06" version="1" precursor="true">MNKDKATGALLMVISVVVILAYLIILWYPPIAAKAALTLLKLTGSIAVLAIFAIIGWIGYTLVTTPPPKPIEEIEKELEKELKEIEKETKEESQKQANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9F8</accession>
    <name>L0A9F8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane-bound serine protease (ClpP class)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232403.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0762"/>
    <dbReference type="EnsemblBacteria" id="AFZ70506">
        <property type="protein sequence ID" value="AFZ70506"/>
        <property type="gene ID" value="Calag_0762"/>
    </dbReference>
    <dbReference type="GeneID" id="14212022"/>
    <dbReference type="KEGG" id="clg:Calag_0762"/>
    <dbReference type="eggNOG" id="arCOG01910">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024619_1_1_2"/>
    <dbReference type="OMA" id="KMGHGFA"/>
    <dbReference type="OrthoDB" id="98168at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="342"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="427" mass="45752" checksum="E862F75116522BD8" modified="2013-03-06" version="1" precursor="true">MEKNIKYILVLIMIIGLILSIHMVISKSATNKKPIVIVNFNVPVDIGSSDMMQRALTIAESYNASAIVIVMNTPGGYLNDMINIVNTIEEANKSGIPTYTYVPPNSLAASAGSYIAMATNQIIMGTGSEIGPSTPIVVGGTPLEQNHTEDAMISFMQSLAEKWGRNVTAATNMVLYDIAYTSQQAYQYHLINGISDSFNSALETWNLSSNPQITISENFYEQFLSAISNSTVDGILMTLGVLAILLDLYHPTIILTIIGIIAIILGLIGAEIINASILGITLIIIGAAIMILELKSGHGFALMGGMIVSAIGIYFMAEGIPYIGAGVPNGYLSQLEITGTGAVGIIAGLYIRWVLGPLRRKEKLAGPESLIGKKAVVISPLNPEGEVRVEGIIWRAHCDSCNANVGDTVEIVKIEGLKLIVRKVENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9J5</accession>
    <name>L0A9J5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family hydrolase, diadenosine tetraphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232438.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0800"/>
    <dbReference type="EnsemblBacteria" id="AFZ70541">
        <property type="protein sequence ID" value="AFZ70541"/>
        <property type="gene ID" value="Calag_0800"/>
    </dbReference>
    <dbReference type="GeneID" id="14212060"/>
    <dbReference type="KEGG" id="clg:Calag_0800"/>
    <dbReference type="eggNOG" id="arCOG00419">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_3_2"/>
    <dbReference type="OMA" id="YNIGVNC"/>
    <dbReference type="OrthoDB" id="93754at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="144" mass="16271" checksum="99B539E5F96DB491" modified="2013-03-06" version="1">MGCVFCEISKKEKPAYIIYEDDDIMTILDINPISKGHLLVIPKEHHEGIQDTPVKTLIKAWVTASAFAKIYRVNLNAPGVNVVTNSGSPAGQVIFHFHVHVIPRWDQDGFKKSGRHQLNEKEANEVINMLSNHIDVVKDYLKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9L3</accession>
    <name>L0A9L3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0820"/>
    <dbReference type="EnsemblBacteria" id="AFZ70561">
        <property type="protein sequence ID" value="AFZ70561"/>
        <property type="gene ID" value="Calag_0820"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0820"/>
    <dbReference type="eggNOG" id="arCOG04155">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_835761_0_0_2"/>
    <dbReference type="OMA" id="MVAMDHR"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="334" mass="39471" checksum="110599C3B2F3C754" modified="2013-03-06" version="1">MQVKINQESCEKLGSQLKSLKMKNIDMYDDENYFPPLTESKENVFLYFLVMVSIDHRLRFHDKPFEGFIENKFYHGADALYKLGILKYKDDPSFFYPENLANINIDTVTKWLTIENKEGKKIYPSDIRVRHELLKDIGIKIKKNFSDPYDIITISKGYLRRDYGNGFIDILKIFKAYQDPVEKKAFLLAKFLERRSILSINDPYNKELPIDNHLTRIALRLGIVDVDDTTREKIYANIEFSDWEDILLRLSVRQAYKMVSQYSGIDPFILDDFLWAFGRSCCKTKDPVCKTSCTNECIKITGCKENCIFTKECKAFQNRIYMIPEHNFKNTWWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9L4</accession>
    <name>L0A9L4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231730.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ69832">
        <property type="protein sequence ID" value="AFZ69832"/>
        <property type="gene ID" value="Calag_0040"/>
    </dbReference>
    <dbReference type="GeneID" id="14211300"/>
    <dbReference type="KEGG" id="clg:Calag_0040"/>
    <dbReference type="eggNOG" id="arCOG00144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_3_2"/>
    <dbReference type="OMA" id="GNICYGA"/>
    <dbReference type="OrthoDB" id="42639at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="11"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="473" mass="51769" checksum="390183AF1B6D8BE0" modified="2013-03-06" version="1" precursor="true">MNIDKKYLWIVSISTSFAAILTPLDSTIVSISLPFISRSLKMSYIETIWVPLGYLIALTVLLLPIGRLSDIKGKKKFFTNGYIIFIIGTLMSGLSFNGFELDLWRIIQGIGAAFILAVGGAIITETYPPNMRGRAFGIWSFSVYLGTTIGPVIGGIIVSITSWRYIFFVTLPLAIIGYILSTKYIKETNIKLNEKMDYTGSALLIIGLFSIVYGLTYGSFIGWNIYSILFSIFGLTVFGLFLAYEYKNSYKAILDVNLLKNNVMFTAGNLAALLNYTGYFYLSFFISFYMQIILIFSPLITSIALISLSLSMVILSPISGWLSDKIGSRLLATTGMLLIMVGLLLLIPLGLKATLFDVSLRMIIIGVGMGLFSSPNTSAVMGSVTKDKLGVASGSLNLMRFLGQSLSLAIASLIVASYIPKNVLSSIFTGVAITNYQISAQFFILGLRRLYLISSIIIAVGAVLSALRNKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Q1</accession>
    <name>L0A9Q1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="12">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">kdpB</name>
        <name evidence="13" type="ordered locus">Calag_0873</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="12"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232510.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0873"/>
    <dbReference type="EnsemblBacteria" id="AFZ70613">
        <property type="protein sequence ID" value="AFZ70613"/>
        <property type="gene ID" value="Calag_0873"/>
    </dbReference>
    <dbReference type="GeneID" id="14212133"/>
    <dbReference type="KEGG" id="clg:Calag_0873"/>
    <dbReference type="eggNOG" id="arCOG01577">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025728_2_0_2"/>
    <dbReference type="OMA" id="ILWLWFT"/>
    <dbReference type="OrthoDB" id="17967at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="609"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="678"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ70613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="705" mass="77354" checksum="512A99CA45F4B073" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9S6</accession>
    <name>L0A9S6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative exonuclease of the beta-lactamase fold involved in RNA processing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231708.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0014"/>
    <dbReference type="EnsemblBacteria" id="AFZ69810">
        <property type="protein sequence ID" value="AFZ69810"/>
        <property type="gene ID" value="Calag_0014"/>
    </dbReference>
    <dbReference type="GeneID" id="14211275"/>
    <dbReference type="KEGG" id="clg:Calag_0014"/>
    <dbReference type="eggNOG" id="arCOG00541">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_5_1_2"/>
    <dbReference type="OMA" id="YLKAMLG"/>
    <dbReference type="OrthoDB" id="39954at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="14"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="229"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="425" mass="47481" checksum="39A6C05A0C171C8C" modified="2013-03-06" version="1">MTKIKILGSGKEVGRAGILIEENSRSVLLDYGVNFDEDDRPIFPLHVRPKDIDVVILTHSHLDHIGAAPSLYISIMPKIGATPLTLDVSKILLMDMIKLNGPYLPFDEQSVNDMLTSAETMDYEKPYEYGDFQVTLMDSGHIPGSASVLVETSNNKILYTADMNTIETKLKNPHKLNGVEADTLIIESTYSTSNHPPRDETEKRFIDDVNDVVEKGGIVLVPAFGVSRGQEIMALLEEKGFGYNIWVDGMIRDIAELYIAHSNYLRSPGLLLKAMQEQRLVKGWNDRRKALKQPGVIIASAGMMKGGPSLYYLKKLAHNPRNAVFMVSYQAEKTPGRDILETGSYYDGNTKVEVKARVEWFDFSSHTDRRGILETIKSIQGIQRVILVHGEPEGQKSLAEEIRNHNTNLDIIIPDNGDEINISNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9T1</accession>
    <name>L0A9T1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZnF_CDGSH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0020"/>
    <dbReference type="EnsemblBacteria" id="AFZ69815">
        <property type="protein sequence ID" value="AFZ69815"/>
        <property type="gene ID" value="Calag_0020"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0020"/>
    <dbReference type="eggNOG" id="arCOG01667">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2299202_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZnF_CDGSH" evidence="3">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ69815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="100" mass="11746" checksum="11977EFEE2AC6E27" modified="2013-03-06" version="1">MFSKKIFKLEIILDIYSFLNFYNFSEKSVKGMARIVLHERNHPYAIKLDNGKEIHVCACGLSKNKPYCDGSHRKTQDEEDGKIYMYDENGNRVKIVSFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9T7</accession>
    <name>L0A9T7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231805.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0119"/>
    <dbReference type="EnsemblBacteria" id="AFZ69907">
        <property type="protein sequence ID" value="AFZ69907"/>
        <property type="gene ID" value="Calag_0119"/>
    </dbReference>
    <dbReference type="GeneID" id="14211379"/>
    <dbReference type="KEGG" id="clg:Calag_0119"/>
    <dbReference type="eggNOG" id="arCOG02207">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027539_1_3_2"/>
    <dbReference type="OMA" id="WWSYRGR"/>
    <dbReference type="OrthoDB" id="50766at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ69907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="245" mass="28786" checksum="F2D14D6E77FC7CF1" modified="2013-03-06" version="1">MKILTWNVNGLRSVLSKGLPKELLNFDIIMFQEIKTDTIPDELQNLGYEIYIYPAKRKGYAGTLTMTKIKPKNVLFGIGNEEFDSEGRNITLEFDEFYVINSYFPNAQHGLTRLDYKLSFNSQMEKFLSSLKKPKIICGDFNVAHKEIDIARPKDNVNNPGFTQQERDWMTHFLELGYIDAFRIFHKEPNRYSWWSYRFHAREKNIGWRIDYCVVSSDIVKRVKDCDIMDKIMGSDHAPVYLIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9W2</accession>
    <name>L0A9W2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B-block_TFIIIC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231743.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0053"/>
    <dbReference type="EnsemblBacteria" id="AFZ69845">
        <property type="protein sequence ID" value="AFZ69845"/>
        <property type="gene ID" value="Calag_0053"/>
    </dbReference>
    <dbReference type="GeneID" id="14211313"/>
    <dbReference type="KEGG" id="clg:Calag_0053"/>
    <dbReference type="eggNOG" id="arCOG04153">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142666_0_0_2"/>
    <dbReference type="OMA" id="CYEGGYY"/>
    <dbReference type="OrthoDB" id="127641at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B-block_TFIIIC" evidence="1">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="137" mass="15684" checksum="E1C68C07B9513E0B" modified="2013-03-06" version="1">MPRNSDEVEKAAMETIKEHKEGVLQSELWKMMGLDSREGSRLVLRLAKKGLIKREQVIVNGRRTYRLFVTEKPIESKLLNISLSSILDIPCTTCPHIDECGLGGYYEPSTCPLIELWLKKEVKLASIRKKQLMQQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9X6</accession>
    <name>L0A9X6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0457"/>
    <dbReference type="EnsemblBacteria" id="AFZ70224">
        <property type="protein sequence ID" value="AFZ70224"/>
        <property type="gene ID" value="Calag_0457"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0457"/>
    <dbReference type="eggNOG" id="arCOG04324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156326_0_0_2"/>
    <dbReference type="OMA" id="VILEFYD"/>
    <dbReference type="OrthoDB" id="111491at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="134" mass="14822" checksum="7545298DF0B55A82" modified="2013-03-06" version="1">MTLLFDIIFADINILNLTTIVIPVKIMSEEKPVVVKEFKGEAKIGRVFKNFATLTLKPEDLSSPVTFQMAISRLYESLMKVFESGGPETTYIAEVKITDDTGNQVSIAIDLGNSIPPFSSEKVKADVKVTLHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Y6</accession>
    <name>L0A9Y6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0935"/>
    <dbReference type="EnsemblBacteria" id="AFZ70666">
        <property type="protein sequence ID" value="AFZ70666"/>
        <property type="gene ID" value="Calag_0935"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0935"/>
    <dbReference type="eggNOG" id="arCOG11424">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1700191_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="154" mass="17890" checksum="600292FAE65887F4" modified="2013-03-06" version="1" precursor="true">MKPKLVLLTVIFLVLLIPIISNISFSSNISCNETFNEIQNAYNYISKASSLGYNISKYESLLNESLNYYNSALISNRSNLCNLSYNIAKNISNNGTLIIKSAESHYYFIVALRLLYIFVFLLLSFILYKFSPSIFWKLWIKSHKNYVVEKNDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Z9</accession>
    <name>L0A9Z9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232147.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0483"/>
    <dbReference type="EnsemblBacteria" id="AFZ70249">
        <property type="protein sequence ID" value="AFZ70249"/>
        <property type="gene ID" value="Calag_0483"/>
    </dbReference>
    <dbReference type="GeneID" id="14211743"/>
    <dbReference type="KEGG" id="clg:Calag_0483"/>
    <dbReference type="eggNOG" id="arCOG11637">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1754593_0_0_2"/>
    <dbReference type="OMA" id="CENEARL"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="148" mass="17365" checksum="745045B9DA52A4B5" modified="2013-03-06" version="1">MKRVLSEENLNDFEPTPRAGPCIEEFLGNSEELQEVYSVSQNREYDYVDVLIYDDKFSFYLKLFNDIECLHIMYAIIESCNENEKDFLLKLADEPEVYKVIIKGNCIKLIIPSLPLIRITKIMEKAKINSKQILSYRFTDYSENGDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA07</accession>
    <name>L0AA07_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231783.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0097"/>
    <dbReference type="EnsemblBacteria" id="AFZ69885">
        <property type="protein sequence ID" value="AFZ69885"/>
        <property type="gene ID" value="Calag_0097"/>
    </dbReference>
    <dbReference type="GeneID" id="14211357"/>
    <dbReference type="KEGG" id="clg:Calag_0097"/>
    <dbReference type="eggNOG" id="arCOG00856">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_5_2"/>
    <dbReference type="OMA" id="AWPNTDF"/>
    <dbReference type="OrthoDB" id="13052at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="403"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="497" mass="56093" checksum="E06B3CAF56AD2C87" modified="2013-03-06" version="1">MYTFEYILRRASQLFPDQEIIDVNGRKTYKETYKETLNLITYLKSLGIKRGDVVSIIGLNNIKFFELIYAITTIGGIAYPINIRLPPDQLIYTLNKSSSRYFIYENIFKELADLVKSKINIETVSFNELKFNLGEGKPVSNKNDDAIILFTSGTTGLPKAVLYNQEKMINGALSILNQLTYYNAPAKLSQNDVMFPQIPIYHILSWGSLIIAPLIGAKLIYGGKFDPKIAIEIIEKENVTWISVVPTMMQMLLDTGLSKRGLKVLIGGSPIPDGLVKKMKDLDIHFSAIYGGTDMLAASITIETKHVKNGILDYHKVTHPVPMAEFYIDSKSQNQPGEIWFRAPWMPNGYYNDKEKTMESFTPDGWFKTGDIGYIAEDGGLIVLDRVKDIIKSGGEWIPSSVLEASISELPFISLVAVIAKKDEKWGERPIAVVKLSKETQNAKELIYEHLRKYVNEGKLSKFWLPDDIIIVNDIPLTGTGKIDKKNLKEILKNYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA10</accession>
    <name>L0AA10_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerate dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232588.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0968"/>
    <dbReference type="EnsemblBacteria" id="AFZ70691">
        <property type="protein sequence ID" value="AFZ70691"/>
        <property type="gene ID" value="Calag_0968"/>
    </dbReference>
    <dbReference type="GeneID" id="14212228"/>
    <dbReference type="KEGG" id="clg:Calag_0968"/>
    <dbReference type="eggNOG" id="arCOG01754">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_2"/>
    <dbReference type="OMA" id="YGNIGTQ"/>
    <dbReference type="OrthoDB" id="36410at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="8"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="109"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="309" mass="34612" checksum="14FECDE3998352B8" modified="2013-03-06" version="1">MVLIVDALVVDNVPDRLVFLLRQGGINVDYVPGLQRDNLINVLKNYEILVFRSRLKIDKEIIDSSNKLKYLARFGVGLDNVDIDYAMKKGIKIINAPNSPSKSVAQLIISMILILERHLYTIIESVKKGEWPKGKILGNEVEGKTLGIIGFGRIGRETAKIAHSLGMKILANDIIDVSNDVKKFEGMQVSLDYLLRNSDIISISVPLTPLTYHMINKDTISLIKNNSILINTARGEVIDTKALLENINKFKGIGLDVLEQEPPKDNLFKELISHENVIVTSHIGSETYEAMDRLSEELAKNIIEEVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA52</accession>
    <name>L0AA52_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative PP-loop superfamily ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232680.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1061"/>
    <dbReference type="EnsemblBacteria" id="AFZ70783">
        <property type="protein sequence ID" value="AFZ70783"/>
        <property type="gene ID" value="Calag_1061"/>
    </dbReference>
    <dbReference type="GeneID" id="14212321"/>
    <dbReference type="KEGG" id="clg:Calag_1061"/>
    <dbReference type="eggNOG" id="arCOG00039">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081854_1_0_2"/>
    <dbReference type="OMA" id="EPLYPDC"/>
    <dbReference type="OrthoDB" id="90765at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01995">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="277" mass="31662" checksum="DDB2CBDB1CFD7715" modified="2013-03-06" version="1">MSSLGIKPTIKQPCKAVSIMSGGPDSTCYTALWLSRGCDVHVLSFIYGQKGNKEVEIAKEMIKKLNNLSKKFNNFGKIVEHKVVDMSFMGELWKETQLTDNSVKVEESYMPSVVVPIRNVVMLSIATAYAYSILQNYKGNIYIIYGSHYDDIKPREDTYEPLYPDCSPECIESLQSSFKICHFRGDRNIEIWSPSKEGYKKSDLIKTCYGILENSIYDTWSCYLSEKYHCGKCESCKNRHSAFIKAGLNDCTKYLNPIDDSFVKVDDYYISKDCIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA53</accession>
    <name>L0AA53_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_1019</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232638.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1019"/>
    <dbReference type="EnsemblBacteria" id="AFZ70741">
        <property type="protein sequence ID" value="AFZ70741"/>
        <property type="gene ID" value="Calag_1019"/>
    </dbReference>
    <dbReference type="GeneID" id="14212279"/>
    <dbReference type="KEGG" id="clg:Calag_1019"/>
    <dbReference type="eggNOG" id="arCOG04147">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_2_2_2"/>
    <dbReference type="OMA" id="KWGSFDK"/>
    <dbReference type="OrthoDB" id="74803at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="97"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="211" mass="23968" checksum="B4519AF4BB018604" modified="2013-03-06" version="1">MVSYKRYELPPLPYSYDALEPVLSRDILTYHHDKHHLAYVNGANAAMEKLEKYLNGQEQSIDIRAVSRDFEFNYGGHLLHTLYWLNMAPTGKGGGTPGGTIADAINKNFGSFDKFKKVFGDAAKLVEGVGWAILALDPVTGDLKITQVEKHNAVITMNLVPLLACDVFEHAYYLQYKNDRGSYVDKWWDVVNWDDVEKRYQKALTLPKLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA78</accession>
    <name>L0AA78_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231925.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0245"/>
    <dbReference type="EnsemblBacteria" id="AFZ70027">
        <property type="protein sequence ID" value="AFZ70027"/>
        <property type="gene ID" value="Calag_0245"/>
    </dbReference>
    <dbReference type="GeneID" id="14211505"/>
    <dbReference type="KEGG" id="clg:Calag_0245"/>
    <dbReference type="eggNOG" id="arCOG00853">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034446_2_1_2"/>
    <dbReference type="OMA" id="HKYAAVV"/>
    <dbReference type="OrthoDB" id="18649at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="3">
        <location>
            <begin position="23"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="2">
        <location>
            <begin position="168"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="450" mass="49952" checksum="9A67E2CE225DC6C9" modified="2013-03-06" version="1">MSEGESATAEWYKLSVELHRYYGGKIEIIPKVPVRRLKDFAIWYTPGVAEASRLSSKNPDLSFELTSRWNTIAVVSDGTRVLGLGNIGPEGAYPVMEGKALIYKYLGGVDAVPLVHRGKDPEKFLELLELIEPSYGGINLEDIEHPKCFYILDEARKRLKIPVWHDDQQGTATITLAGLINALKIVKKSIKDVRIVLYGAGASNVAFYRLLKQLISNMENVVAITTKGILHPEMPNIDKLMISNKWQYDIAIETKGGGLPPNSTIDKAFENADVVIAASTPGPDTLKKEWISKMNKDAIVFALANPVPEIWPQDAKKAGAKIVATGRSDFPNQINNSLAFPAIFRGVLDVRAKTISDTMAITAAYEIAKFAEEKGLSENYIVPTMEEWEVYPRVAAAVAVKAVEEGVARKTTTYKEELQRAKDIISSIREKIGFLWDRGYIPKPLVDYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA80</accession>
    <name>L0AA80_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232668.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1049"/>
    <dbReference type="EnsemblBacteria" id="AFZ70771">
        <property type="protein sequence ID" value="AFZ70771"/>
        <property type="gene ID" value="Calag_1049"/>
    </dbReference>
    <dbReference type="GeneID" id="14212309"/>
    <dbReference type="KEGG" id="clg:Calag_1049"/>
    <dbReference type="eggNOG" id="arCOG00332">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023081_2_1_2"/>
    <dbReference type="OMA" id="CYLGRAN"/>
    <dbReference type="OrthoDB" id="34668at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="209"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="312" mass="35602" checksum="0875FC78D59683A8" modified="2013-03-06" version="1">MRIRELIDFMSDLTLKTGYPVPVPKDFAYKWATNLNFSRKGKKILYTGALYQLIPYIEALSIYLKAMESSDEGAYLALRFTRNIPGSLINSIIKPEPSLIEWSNRVLLNIANLLLKSKIEFSYLYDKDVYSGVLLYDMGAEEKFEIHAKNVFNILKESGAEEIITVDPHTTFILKNIYPKYIKEFNFDVKSYLELINNEGEIKKDGETITIHDSCIYARGLSIIERPRSLLSNKGFIIKEANRNKKLTSCCGGPVEAIFPSLSNAIARNRVKELSSVSNEIVTMCPICYINLKKVSKDYNSTIYDISELLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA98</accession>
    <name>L0AA98_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1069</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232688.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1069"/>
    <dbReference type="EnsemblBacteria" id="AFZ70791">
        <property type="protein sequence ID" value="AFZ70791"/>
        <property type="gene ID" value="Calag_1069"/>
    </dbReference>
    <dbReference type="GeneID" id="14212329"/>
    <dbReference type="KEGG" id="clg:Calag_1069"/>
    <dbReference type="eggNOG" id="arCOG00749">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_10_0_2"/>
    <dbReference type="OMA" id="IKEQTYV"/>
    <dbReference type="OrthoDB" id="34606at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="247"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="449" mass="49013" checksum="27AD883C6A3A8666" modified="2013-03-06" version="1">MSNEVGIKSYINVLIKNKSGLIGIIMIIIYVILSIYGVVNYGYVSQEWKNIPYWETYPKVAQPAWMSIFNPSKIFTTVSYTSKPSLIYSGNGLNIYQITYNFTWNKDVPPSDVVFYLSTNGSLQSLQVLWIKPNGNNFTMSISSSPGNINDLVSFSSSIQSYIATQVKTVPSQITAPILSKALFGYPGPNLLNGTAMKGTYKAVVTIISSQNVKILSNRIYLEGNAYGLFGTDIDGRPLDLGILLGFSNALEIGLLTSIISVIGGVIVGGISGYLGGKVDSGLNWLTLVILVLPALPFLVVLSFVMRPNLLLESLLIAFLSWPFYAIIARSAAQSIKNEVFVEADKVLGIPSYRTFLTHFMPRLTPFAIAYTALGVPAAIILVQTLAFLGLAPYGILTWGTILNSAESNFAAVNGWWWWILFPGIMIILVSIPFVMIGFAIEKAIFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA99</accession>
    <name>L0AA99_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232730.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70833">
        <property type="protein sequence ID" value="AFZ70833"/>
        <property type="gene ID" value="Calag_1111"/>
    </dbReference>
    <dbReference type="GeneID" id="14212371"/>
    <dbReference type="KEGG" id="clg:Calag_1111"/>
    <dbReference type="eggNOG" id="arCOG03694">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183045_3_0_2"/>
    <dbReference type="OMA" id="MLWVGSY"/>
    <dbReference type="OrthoDB" id="129470at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021741">
        <property type="entry name" value="DUF3311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40034">
        <property type="entry name" value="PTHR40034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11755">
        <property type="entry name" value="DUF3311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="72" mass="8387" checksum="E4059EEC7842EDCD" modified="2013-03-06" version="1">MKEGNKRLSSGEIIIIAILLIIPFLVYLLYPTYNKVEPTLGGLSFFYWYQTLWLALSGILFAIAAYIWDRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAB2</accession>
    <name>L0AAB2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NurA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231878.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0198"/>
    <dbReference type="EnsemblBacteria" id="AFZ69980">
        <property type="protein sequence ID" value="AFZ69980"/>
        <property type="gene ID" value="Calag_0198"/>
    </dbReference>
    <dbReference type="GeneID" id="14211458"/>
    <dbReference type="KEGG" id="clg:Calag_0198"/>
    <dbReference type="eggNOG" id="arCOG00287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_827970_0_0_2"/>
    <dbReference type="OMA" id="MVYVKVR"/>
    <dbReference type="OrthoDB" id="65233at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="50"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="336" mass="38724" checksum="86241CE1F769BF58" modified="2013-03-06" version="1">MEFHKAVKDLISILSEISKERPYLGIEFSNYSEASEIYEVDKIWDCDDFKTFSYLDSSSRVLSVRGANIYISSLYANDNGKHIMIPLQASIPFMAIKGDREVIDKIKSSYLSSFVITENINGFRYDESYKDDNILDELRINLENHVINSSNNIMIVDGPVFPGPYLPMVGEPYRSTYETLILNRKTDNLVGIVKRLNYSRKLSRVRGLWKFNDNATDDVITMYLGKNEIIYVSPIYEEKVELTNKSLKRYMVYCKVRDSVFRVESPDKEMLCKGVKTAINHSSYRGIPTFIESADKLSRKLGASAFLISFIYAKSMIGVNYEDWLNYQRASLEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAB3</accession>
    <name>L0AAB3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232262.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0607"/>
    <dbReference type="EnsemblBacteria" id="AFZ70364">
        <property type="protein sequence ID" value="AFZ70364"/>
        <property type="gene ID" value="Calag_0607"/>
    </dbReference>
    <dbReference type="GeneID" id="14211867"/>
    <dbReference type="KEGG" id="clg:Calag_0607"/>
    <dbReference type="eggNOG" id="arCOG00280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023842_2_0_2"/>
    <dbReference type="OMA" id="CLVSQRP"/>
    <dbReference type="OrthoDB" id="33242at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="140"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="512" mass="56631" checksum="DB7B40E89019E96F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAC1</accession>
    <name>L0AAC1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Proliferating cell nuclear antigen homolog</fullName>
            <shortName evidence="3">PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcn</name>
        <name evidence="8" type="ordered locus">Calag_0208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231888.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0208"/>
    <dbReference type="EnsemblBacteria" id="AFZ69990">
        <property type="protein sequence ID" value="AFZ69990"/>
        <property type="gene ID" value="Calag_0208"/>
    </dbReference>
    <dbReference type="GeneID" id="14211468"/>
    <dbReference type="KEGG" id="clg:Calag_0208"/>
    <dbReference type="eggNOG" id="arCOG00488">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_1_0_2"/>
    <dbReference type="OMA" id="TIRKDPN"/>
    <dbReference type="OrthoDB" id="70433at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PTHR11352:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA_N" evidence="6">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="PCNA_C" evidence="7">
        <location>
            <begin position="138"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ69990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="258" mass="28799" checksum="0437080250E0197C" modified="2013-03-06" version="1">MESSIESQIGKAKAKFKYPDSRVLRQMTSTLAEIVEEANFEISKNGVKVVATDPGKITYLEINMPYETFLDYEVDQETNMGVNIQSLDNIVSRGKKGENVDFLVSDQYILIKIEGDVIKKYLIPNIEVVIDVPKDIKLDFDSRVVIIGDTFKKILTDASAFGDVVELEVDENSFKIRAKGEGPKAEVNLSKGSSSLIDLESKKKSVSSYDVNFLKSVLNLAKIAETVEIRFSSDKPIELIFNAPDKSKIRYLLAPTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAD1</accession>
    <name>L0AAD1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="6">PTH</shortName>
            <ecNumber evidence="6">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pth</name>
        <name evidence="7" type="ordered locus">Calag_0629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0629"/>
    <dbReference type="EnsemblBacteria" id="AFZ70384">
        <property type="protein sequence ID" value="AFZ70384"/>
        <property type="gene ID" value="Calag_0629"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0629"/>
    <dbReference type="eggNOG" id="arCOG04228">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073661_2_2_2"/>
    <dbReference type="OMA" id="GHAAVEC"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00628">
        <property type="entry name" value="Pept_tRNA_hydro_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034759">
        <property type="entry name" value="Pept_tRNA_hydro_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PTHR12649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="121" mass="13417" checksum="5ECFBDE77722CF0D" modified="2013-03-06" version="1">MVMKQSIVLRKDLKMGHGKAAAQASHASCDAIFEIIDSNKKDWKEWLDLWKKQGQMKVVLKVNSRDEIEEIYNQALQLGLPCSIISDAGRTQLPPGTITAVAIGPGPEEIIDKITGKLKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-12-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAD6</accession>
    <name>L0AAD6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD superfamily phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1151"/>
    <dbReference type="EnsemblBacteria" id="AFZ70873">
        <property type="protein sequence ID" value="AFZ70873"/>
        <property type="gene ID" value="Calag_1151"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1151"/>
    <dbReference type="eggNOG" id="arCOG04430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515462_0_0_2"/>
    <dbReference type="OMA" id="DARYKMY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="69"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="539" mass="62322" checksum="43BFE49D5E3F591D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAG2</accession>
    <name>L0AAG2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/FMN-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231928.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0248"/>
    <dbReference type="EnsemblBacteria" id="AFZ70030">
        <property type="protein sequence ID" value="AFZ70030"/>
        <property type="gene ID" value="Calag_0248"/>
    </dbReference>
    <dbReference type="GeneID" id="14211508"/>
    <dbReference type="KEGG" id="clg:Calag_0248"/>
    <dbReference type="eggNOG" id="arCOG00337">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_9_2_2"/>
    <dbReference type="OMA" id="CNDNMLA"/>
    <dbReference type="OrthoDB" id="77247at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="39"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="476" mass="52452" checksum="791EACF828DB03C8" modified="2013-03-06" version="1">MVQKNIEDFINEVTSSIGKNKIITDNLILKLYSKEPSGLMGNISAVIFPESKEDVSKILSIAYKYEVNIYPQGSSSSLSGNAVPLRDGVIVSFERMNKIKDLSITDNIVIAEPGVRIDELNLFLEKYNYMFPIDPASQSVATIGGAINNGAGGLKGAKYGTMKDWVNGMEIALPDEKGTRLFVGCMTVKCRKGYDLARLIIGSEGTLALVTEAVLRITPIPESIVTSLALFDNLDDLLNSFIEIKSIGMQPYIAEFMDSKTVEVASKGVDINFEPKGNMLLLSIDTNKESTERMKKFLEDTLKKHNANKIITSLSQQEAEELGLFKIRRNLFAAQVSMGYSLYGNGKKLQVFIEDIVVPPSKIKLAINKIREVSENYGLFVSIGGHIGDGNIHPSVVYDVTDENMKTKVVSWYKDVMKIALDLNGSVSAEHGIGLLKKDGLIMEMTHYNSLKEIDIMKSIKSLFDPKGILNPGKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAG4</accession>
    <name>L0AAG4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl3</name>
        <name evidence="7" type="ordered locus">Calag_0670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232317.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0670"/>
    <dbReference type="EnsemblBacteria" id="AFZ70419">
        <property type="protein sequence ID" value="AFZ70419"/>
        <property type="gene ID" value="Calag_0670"/>
    </dbReference>
    <dbReference type="GeneID" id="14211930"/>
    <dbReference type="KEGG" id="clg:Calag_0670"/>
    <dbReference type="eggNOG" id="arCOG04070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033361_2_0_2"/>
    <dbReference type="OMA" id="HQRTEYN"/>
    <dbReference type="OrthoDB" id="31722at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_A">
        <property type="entry name" value="Ribosomal_L3_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019928">
        <property type="entry name" value="Ribosomal_L3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="PTHR11363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03626">
        <property type="entry name" value="L3_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="345" mass="38598" checksum="366C2CA8CD724B5C" modified="2013-03-06" version="1" precursor="true">MGHRKKSAARRGSLGFYPRQRAVEFVPRIKSWPTLSIQEPKLLGFIGYKVGMTHVFIIENRQGLPTYGKEVMRPVTIVETPPVYVLAVRGYAFDLNKGLYPLTEAWSKIPNDLELERRISTLGEFDTEGSIKELQKSANELKEIRVLIASQPKLTGGLSKKKPDVIEVKVNAPSNDVKKALDFAINKLGQQVTVKDVFQPGQVIDVLAVSKGKGWQGVIKRAGAKQLPRWTKHRKGSRKIGARSHGLGTWWENPSPGQLGFHRRTDYNKRILDIGDEGYKVTPAGGFINYGIVKSSYIMLEGSIPGVVKRPIVLRYPIRPPVWYLSMGIKKPQITYISLSSKQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAM1</accession>
    <name>L0AAM1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231983.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0306"/>
    <dbReference type="EnsemblBacteria" id="AFZ70085">
        <property type="protein sequence ID" value="AFZ70085"/>
        <property type="gene ID" value="Calag_0306"/>
    </dbReference>
    <dbReference type="GeneID" id="14211566"/>
    <dbReference type="KEGG" id="clg:Calag_0306"/>
    <dbReference type="eggNOG" id="arCOG01052">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01054">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_2_1_2"/>
    <dbReference type="OMA" id="YRNPMVV"/>
    <dbReference type="OrthoDB" id="56448at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="5">
        <location>
            <begin position="345"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="674" mass="74420" checksum="BD6EF34D94BAEA08" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAN7</accession>
    <name>L0AAN7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232070.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0402"/>
    <dbReference type="EnsemblBacteria" id="AFZ70172">
        <property type="protein sequence ID" value="AFZ70172"/>
        <property type="gene ID" value="Calag_0402"/>
    </dbReference>
    <dbReference type="GeneID" id="14211662"/>
    <dbReference type="KEGG" id="clg:Calag_0402"/>
    <dbReference type="eggNOG" id="arCOG01042">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131306_1_1_2"/>
    <dbReference type="OMA" id="CHATEDC"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="143" mass="16688" checksum="E001571407B74B9E" modified="2013-03-06" version="1">MIKSLEIRVFVHATEDKEKIVSSLKNIIKEDFNIIEEQYEGYYGNSILVISSIIEGSKAEEILNNLLDSLSRPDKDELIKTFYDRIEEKNNTFHLRLNKQKAYSGQLTLSDSDDVIKLIFKLENKFEIEKLKNLIIEKYNKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAS2</accession>
    <name>L0AAS2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl1</name>
        <name evidence="6" type="ordered locus">Calag_1306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds directly to 23S rRNA. Probably involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1306"/>
    <dbReference type="EnsemblBacteria" id="AFZ71018">
        <property type="protein sequence ID" value="AFZ71018"/>
        <property type="gene ID" value="Calag_1306"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1306"/>
    <dbReference type="eggNOG" id="arCOG04289">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_4_0_2"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="OrthoDB" id="70269at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_A">
        <property type="entry name" value="Ribosomal_L1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023669">
        <property type="entry name" value="Ribosomal_L1_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="214" mass="23576" checksum="7E3364C08AD44B40" modified="2013-03-06" version="1">MPLDNEIIKGAVEKAKMLGKQRKFKQTVELIVALKDINLKGNEGKFREVVYLPHAPSKEPNICVIASGDLLLEAKKLGLRTISREELSAMKGNKKAARNIGNSCDWILVSSDLMSLVGSILGPALGPRGKVPIAISPKSNISDVVNNYKRAVWARIRNEPQIQCKVGTEDMKNEEIIDNINAVFNTIESKIGIAKIARVYVKKTMGFPVEIALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAS8</accession>
    <name>L0AAS8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232018.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0343"/>
    <dbReference type="EnsemblBacteria" id="AFZ70120">
        <property type="protein sequence ID" value="AFZ70120"/>
        <property type="gene ID" value="Calag_0343"/>
    </dbReference>
    <dbReference type="GeneID" id="14211603"/>
    <dbReference type="KEGG" id="clg:Calag_0343"/>
    <dbReference type="eggNOG" id="arCOG01350">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064691_0_0_2"/>
    <dbReference type="OMA" id="RGNQQFS"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039065">
        <property type="entry name" value="AcoX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011386">
        <property type="entry name" value="Put_ATP-NAD_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40697">
        <property type="entry name" value="PTHR40697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016907">
        <property type="entry name" value="Kin_ATP-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="365" mass="40714" checksum="BF4D966B90AD0FAB" modified="2013-03-06" version="1">MKIGLIINPIAGMGGRVGLKGTDGNLYQKALKLGAQPISINRTLDFLNNLSLVNELFFIVPNGIMGEYVIKESKIKNYKVIQCSQDNYNTNRYDTINCSKLIAKEVNILVFSGGDGTARDIYDSIKDSIPVIGIPSGVKMYSPLFAKNPKDAAKVIESYFYGNSNITLKEVLDIDEDEYRNNKLKIKLYGYMKSISSEGMINVGKQAVYSVDEDEIMGISNYIKEIIKQDVFYIVGPGSTTYNVFKNLGLEKTLLGVDLIKNYEIIKYDANENDLLNYINNQRVKIIVSPIGGQGFLFGRGNQQISPKILKIVGKDNILVISTISKLSSLKYLLVDTGDENADNMLKGYIKVIIGYKQEKIMKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAV0</accession>
    <name>L0AAV0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Preprotein translocase subunit SecY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Calag_0371</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232043.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0371"/>
    <dbReference type="EnsemblBacteria" id="AFZ70145">
        <property type="protein sequence ID" value="AFZ70145"/>
        <property type="gene ID" value="Calag_0371"/>
    </dbReference>
    <dbReference type="GeneID" id="14211631"/>
    <dbReference type="KEGG" id="clg:Calag_0371"/>
    <dbReference type="eggNOG" id="arCOG04169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031763_3_0_2"/>
    <dbReference type="OMA" id="KWGIGSG"/>
    <dbReference type="OrthoDB" id="13531at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="396"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Plug_translocon" evidence="11">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="454" mass="49303" checksum="5196DC9DDDA555CD" modified="2013-03-06" version="1">MGALDVLANWSSYLPTIKKPKQKLTLYRRLAWTGIILVIYLIMANIPLYGVPTQALTSTISLQNIIFASSAGTLMQLGIGPIVTSGLILEVLAGAKIIDIDLSNPDDQLKFTGAMKTLAVILAVVESVVVMLSGELFPVGFSASLLVKVLIVIQLTFASFLVILMDEALQKGWGLGSAISLFILAGVAQTVIWDMFGFIPHIAMDFGVIPAIIIDKNLLVFARPNGFPDLTGLLSTFAIIILLVYLNGMRVEIPVTSSRLRGIRSRIPLQFIYVTNIPILLLAILVADLQLFETPIERFLGAGSIVYKGYADLVYYLSPPNGIISASINPLKTVIFAITWLILSILFGYLWVEVAGLNPSSQAEQLISGGMEIPGMRRNPKILESVLSRYIYPLTVLSSLIVGAIAIVAAIFGSFGTGAGILLAVGIIYQYYSMISYERALEAYPLIRRIMGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAW8</accession>
    <name>L0AAW8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232923.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1314"/>
    <dbReference type="EnsemblBacteria" id="AFZ71026">
        <property type="protein sequence ID" value="AFZ71026"/>
        <property type="gene ID" value="Calag_1314"/>
    </dbReference>
    <dbReference type="GeneID" id="14212574"/>
    <dbReference type="KEGG" id="clg:Calag_1314"/>
    <dbReference type="eggNOG" id="arCOG04103">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2629676_0_0_2"/>
    <dbReference type="OMA" id="RLHYRCP"/>
    <dbReference type="OrthoDB" id="123039at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="86" mass="9462" checksum="560AF472D0D0123D" modified="2013-03-06" version="1">MTIGLAKGANSMGHVGWITVRCRICGRYLDLSGQKPNARHEEVVYACPKCAKTLNVYFCAADAKRLRYHCPYCGSQLTVVSPLIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAY0</accession>
    <name>L0AAY0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Translation initiation factor 2 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">aIF2-beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 9">eIF-2-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">eif2b</name>
        <name evidence="11" type="ordered locus">Calag_1325</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterotrimer composed of an alpha, a beta and a gamma chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232933.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1325"/>
    <dbReference type="EnsemblBacteria" id="AFZ71036">
        <property type="protein sequence ID" value="AFZ71036"/>
        <property type="gene ID" value="Calag_1325"/>
    </dbReference>
    <dbReference type="GeneID" id="14212585"/>
    <dbReference type="KEGG" id="clg:Calag_1325"/>
    <dbReference type="eggNOG" id="arCOG01640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026663_3_1_2"/>
    <dbReference type="OMA" id="GKPDTRL"/>
    <dbReference type="OrthoDB" id="96453at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00232">
        <property type="entry name" value="eIF_2_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004458">
        <property type="entry name" value="TIF2_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="PTHR23001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="SSF100966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="SSF75689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF2B_5" evidence="10">
        <location>
            <begin position="27"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ71036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="142" mass="16235" checksum="DAA6A34F715FFC64" modified="2013-03-06" version="1">MQDDKLLQDYDKLLERVYKKIPPKSGTSDLQLPEPQLIRVGTQSIIKNFRDISQKLKRDPTLVSRYLLKELASAGSYEEVSGQLVLNVKVSRKVIEQLLDIFIKSYVKCPTCGSIDTRIEHRGKIWILRCEACGAEQPIKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAY6</accession>
    <name>L0AAY6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP-dependent dephospho-CoA kinase</fullName>
            <ecNumber evidence="3">2.7.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Dephospho-coenzyme A kinase</fullName>
            <shortName evidence="3">DPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3'-dephospho-CoA + GTP = CoA + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61156"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP-dependent DPCK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232088.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0421"/>
    <dbReference type="EnsemblBacteria" id="AFZ70190">
        <property type="protein sequence ID" value="AFZ70190"/>
        <property type="gene ID" value="Calag_0421"/>
    </dbReference>
    <dbReference type="GeneID" id="14211681"/>
    <dbReference type="KEGG" id="clg:Calag_0421"/>
    <dbReference type="eggNOG" id="arCOG04076">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120795_1_0_2"/>
    <dbReference type="OMA" id="AIYDHKT"/>
    <dbReference type="OrthoDB" id="116732at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00590">
        <property type="entry name" value="Dephospho_CoA_kinase_GTP_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007164">
        <property type="entry name" value="GTP-dep_dephospho-CoA_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40732">
        <property type="entry name" value="PTHR40732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04019">
        <property type="entry name" value="DUF359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006533">
        <property type="entry name" value="UCP006533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="177" mass="20087" checksum="70F9770E50139434" modified="2013-03-06" version="1">MKFVGLTLPENVRYDFSQPRGRVISGELKSYIESREWNFVICVGDVVTYYCLKANRKPDIIIIDGKTLRSKEGFSFDSNPIDYNLIKIKNPPGMLTYDNIDLLCNILKSKNKEKILIYVDGEEDLLALPTLSCAQDNSLVIYGIPNKGAALVNVNNYIRRELQNKILVLKPGIIETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB11</accession>
    <name>L0AB11_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0568</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232225.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0568"/>
    <dbReference type="EnsemblBacteria" id="AFZ70327">
        <property type="protein sequence ID" value="AFZ70327"/>
        <property type="gene ID" value="Calag_0568"/>
    </dbReference>
    <dbReference type="GeneID" id="14211828"/>
    <dbReference type="KEGG" id="clg:Calag_0568"/>
    <dbReference type="eggNOG" id="arCOG01608">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002569_5_0_2"/>
    <dbReference type="OMA" id="MKSNYIS"/>
    <dbReference type="OrthoDB" id="29908at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="4">
        <location>
            <begin position="13"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="5">
        <location>
            <begin position="260"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="397" mass="44110" checksum="9C083E6B2B275AB6" modified="2013-03-06" version="1">MIKTLTGNYAVAEAAKLARIKVTSAYPITPQTTIVEKLSEMIEKGELEAKMIRVESEHSALAATLGAAAAGSRAFTATASHGLLYMHEVLWWTASARIPVVMAVATRAIGAPWNIHVEHSDIVDQRDTGWIIGIAQENQEVLDMTIQAFAISEDPRVYLPMIVGLDGFILTHTVAPVNVPDQKDVDNWLPPRRQPYVITPESKIAMGNMTSDEDYYMMRYSIQVGQEAAKKVIEEVDNSYGKAFGRSYGGLVECYKCEDADYVMVLMGSWAGDAKEAINSLRNKGINAGIARIRFIRPWPAEILREKLSNKKGVLVFDRSISFGNTGQLFTELSSTLYGMTSMRGVIAGLGGVDVLPEDFQNEMIDFVNKVEENGKVYDPIKWLFPMKYRKIEEVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB13</accession>
    <name>L0AB13_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">30S ribosomal protein S4e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps4e</name>
        <name evidence="10" type="ordered locus">Calag_1379</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232985.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1379"/>
    <dbReference type="EnsemblBacteria" id="AFZ71088">
        <property type="protein sequence ID" value="AFZ71088"/>
        <property type="gene ID" value="Calag_1379"/>
    </dbReference>
    <dbReference type="GeneID" id="14212639"/>
    <dbReference type="KEGG" id="clg:Calag_1379"/>
    <dbReference type="eggNOG" id="arCOG04093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060400_0_0_2"/>
    <dbReference type="OMA" id="FPVGLMD"/>
    <dbReference type="OrthoDB" id="89943at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="KOW_RPS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_S4e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_S4e_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_S4e_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_S4e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="PTHR11581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ71088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="252" mass="28371" checksum="778F589A2B586A3D" modified="2013-03-06" version="1">MGNMGGTRSIKGIAAPPFWPIERKLRPWTPKPSPGPHNAEQSLPLLVVLRDMLKYAETGKEAIKIINENKIKVDGRVVNDYKYPLSVMDVLEIPENDEYYRVIPYPTDYLGLYKITKEEASLKPVRIENKTIVKGGNLQLNLSGGRNILVKFKEGEKKEVPYKTLDTLLITLPNQEIKEHIPFQIGDYALVIWGKNVGKLGKIVSVNKQWGRKSSTVTLEGKSGRKIQTILDYILIVGKEKPVISLPGEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB21</accession>
    <name>L0AB21_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="3">RPPK</shortName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="3">P-Rib-PP synthase</shortName>
            <shortName evidence="3">PRPP synthase</shortName>
            <shortName evidence="3">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prs</name>
        <name evidence="7" type="ordered locus">Calag_0579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0579"/>
    <dbReference type="EnsemblBacteria" id="AFZ70337">
        <property type="protein sequence ID" value="AFZ70337"/>
        <property type="gene ID" value="Calag_0579"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0579"/>
    <dbReference type="eggNOG" id="arCOG00067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_2_2_2"/>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="OrthoDB" id="59314at2157"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_A">
        <property type="entry name" value="RibP_PPkinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037514">
        <property type="entry name" value="Rib-P_diPkinase_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="6">
        <location>
            <begin position="13"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="157"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="3">
        <location>
            <begin position="222"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="297" mass="33041" checksum="452919346DCD7E6B" modified="2013-03-06" version="1">MKNIVISGTNMVSEEIAKSLANSLSAELCKPIYKVFPDGESYVRLPCNVKDSKAIVVQSLINPQDKSIIEAILLGDAIKESGAKDQILITPYLAYSRQDKVFLEGEPISIRGILKIFSDYYNILATIEIHKEDSLKFFNKKAINIRPYTYMAEKIGFDSKNIAVLSPDIGAIDRAKILSSYLNCEYDYFIKARDRITGEITMQTKELDVKGKDIIVVDDIISTGGTILKATQILKNQGARNIYVMVSHALLLENAEEKLFSNGVNKIYAANTLPKKSKVDYIDVGPLIAKNLSAYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB55</accession>
    <name>L0AB55_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232275.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0622"/>
    <dbReference type="EnsemblBacteria" id="AFZ70377">
        <property type="protein sequence ID" value="AFZ70377"/>
        <property type="gene ID" value="Calag_0622"/>
    </dbReference>
    <dbReference type="GeneID" id="14211882"/>
    <dbReference type="KEGG" id="clg:Calag_0622"/>
    <dbReference type="eggNOG" id="arCOG01972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_1_2"/>
    <dbReference type="OMA" id="QRVDMIN"/>
    <dbReference type="OrthoDB" id="110723at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="147" mass="16917" checksum="452AA664DE907ADD" modified="2013-03-06" version="1">MPDISDLDDPELKEILSRKAMEIIKESSKKDNNKNIDINEGPIELNDNNFDEFISKNKGVVVDFWAPWCAPCHMLSPMLEDLSTKYTDIKFVKVNADESPMTASKFYVMSLPTTMLFLNGEPVDRIVGVVPYEVLEERIRWLQAKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB59</accession>
    <name>L0AB59_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232993.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1387"/>
    <dbReference type="EnsemblBacteria" id="AFZ71096">
        <property type="protein sequence ID" value="AFZ71096"/>
        <property type="gene ID" value="Calag_1387"/>
    </dbReference>
    <dbReference type="GeneID" id="14212647"/>
    <dbReference type="KEGG" id="clg:Calag_1387"/>
    <dbReference type="eggNOG" id="arCOG01815">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_592654_0_0_2"/>
    <dbReference type="OMA" id="GINDEMP"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="461" mass="52092" checksum="B4C3784ED2B385AD" modified="2013-03-06" version="1">MINLIKPKNIDNLKIDIKSAILINKVSYILRIASFPLLSISGYFLHIHKIIDSIIILVFALLFFFSNFWITDLWLKLVDNGIENELPTLLAFLIPYAATTKNLVDLLLNIPKSLKLFYINKEIERLKLLLNFTQDSRKALSQLGETTPNARFRRLIIEHVQTETMGTSKNRITMLLYRYAILGIRDRWRNYTILGKELAEIDIGIMLSIGMLAVLMLLGNYNLLSILLLLGLFLIPISSIILILTRPKIGEPEGNFFIITISIISPLISSFLILRGFQYLSIVPFIISIPILEIYNYNKSKEADNALSYLRIASEKAKLGKRFDIELNKSKILAKNIIQGILESEKIAGKVGASNAIEGLRLIIEESRRLSNLIKAQSLFMISIALFSPLISIMAINIISNTFLTASQFLPINYDMVNTSRIIIASLSPLSTLPISILYRGKNPTLIPNLLSTLITLFVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB64</accession>
    <name>L0AB64_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Zn ribbon-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0529"/>
    <dbReference type="EnsemblBacteria" id="AFZ70290">
        <property type="protein sequence ID" value="AFZ70290"/>
        <property type="gene ID" value="Calag_0529"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0529"/>
    <dbReference type="eggNOG" id="arCOG04136">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165872_0_0_2"/>
    <dbReference type="OMA" id="KIFTCPH"/>
    <dbReference type="OrthoDB" id="118965at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="109" mass="12583" checksum="712024C1D2945A95" modified="2013-03-06" version="1">MARRRRKKSLKPKKPRHPSRYFQCPRCGSVTLTIDFAKIGGNEDEKMAIAKCGNCHLYCELKVPRVLDRVDVYNKIVDLSYDNKLSECEKTESETEAETEEEVDDEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB69</accession>
    <name>L0AB69_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Holliday junction resolvase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1398"/>
    <dbReference type="EnsemblBacteria" id="AFZ71106">
        <property type="protein sequence ID" value="AFZ71106"/>
        <property type="gene ID" value="Calag_1398"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1398"/>
    <dbReference type="eggNOG" id="arCOG05252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105716_1_0_2"/>
    <dbReference type="OMA" id="YRINTTN"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019287">
        <property type="entry name" value="Hday_junct_resolvase-rel_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10107">
        <property type="entry name" value="Endonuc_Holl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuc_Holl" evidence="2">
        <location>
            <begin position="27"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="157" mass="17997" checksum="8DAD71A35D29B550" modified="2013-03-06" version="1">MSILIYALISIILIELIVILYLYISNWRKSVKIDSIKSNIENLANEKAKVIAMESIEKARKEAVQQSKAVITGKVYEQFAPYLPNFKHNPKEARFIGSPIDYIVFDGIENNDVKAIYFVEIKSGKSNLTNREESIKKAVEKKAVYFETIYIDDKNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB71</accession>
    <name>L0AB71_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH:ubiquinone oxidoreductase subunit 1 (Chain H)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233035.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1431"/>
    <dbReference type="EnsemblBacteria" id="AFZ71138">
        <property type="protein sequence ID" value="AFZ71138"/>
        <property type="gene ID" value="Calag_1431"/>
    </dbReference>
    <dbReference type="GeneID" id="14212691"/>
    <dbReference type="KEGG" id="clg:Calag_1431"/>
    <dbReference type="eggNOG" id="arCOG01546">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_2_2"/>
    <dbReference type="OMA" id="WSGWASN"/>
    <dbReference type="OrthoDB" id="88886at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="347" mass="38457" checksum="3123D412ECFC56A0" modified="2013-03-06" version="1">MNVWYYVYRVIIDDIIFYPPVYQFLIIPGLIAALIVALIIIWFERKAAAFVQMRYGPREIAPRIGGAIQLVADLTRYALQEIIIPETVDALPYILSPIIMIILALLPLDAVPITSIKTYFPIPPDYSLLIAVALSTLSPLFVIIMSWASNNKFAIVGGLRESFIITAYELIAVLGFLTVAAMTQSFNLVQIVNLQMSGKWFGLLNPLALLAVFIAVLMSTSGFPFEIPDSESELVAGPYTEYTGLLYGLNMGGAYIKRWVFSVLITLVFLGGWAPYRPTPGIITGYFIPSLIIFIKSLIIMAVMSFLRSVYGRYRVDQALGIAWEILIPLTLAAFGLGLAEAYFGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB83</accession>
    <name>L0AB83_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70402">
        <property type="protein sequence ID" value="AFZ70402"/>
        <property type="gene ID" value="Calag_0650"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0650"/>
    <dbReference type="HOGENOM" id="CLU_3371262_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="34" mass="3919" checksum="F5AF38EF33F5CD84" modified="2013-03-06" version="1">MPKNKTRRKTLLIVFAIILIVVFLIPVIGTIFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB86</accession>
    <name>L0AB86_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">F0F1-type ATP synthase, subunit c/archaeal/vacuolar-type H+-ATPase, subunit K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233018.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1414"/>
    <dbReference type="EnsemblBacteria" id="AFZ71121">
        <property type="protein sequence ID" value="AFZ71121"/>
        <property type="gene ID" value="Calag_1414"/>
    </dbReference>
    <dbReference type="GeneID" id="14212674"/>
    <dbReference type="KEGG" id="clg:Calag_1414"/>
    <dbReference type="eggNOG" id="arCOG02455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_3_0_2"/>
    <dbReference type="OMA" id="YRYIMIV"/>
    <dbReference type="OrthoDB" id="132186at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="7">
        <location>
            <begin position="67"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="131" mass="13497" checksum="3C8FDEADE60AFFE1" modified="2013-03-06" version="1" precursor="true">MDKRIIEGINLIIRESLKRPKYRYIMIVVALISIMAAFITGIAITHAATTSSSITQASAYAELGKAIGAGLAIGLAGIGGGYSVGVAGAAAISAIAENRELFGTSFIFVVLGEGIAIYGLLVAIIILFVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABC3</accession>
    <name>L0ABC3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+ antiporter NhaD-like permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0593"/>
    <dbReference type="EnsemblBacteria" id="AFZ70350">
        <property type="protein sequence ID" value="AFZ70350"/>
        <property type="gene ID" value="Calag_0593"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0593"/>
    <dbReference type="eggNOG" id="arCOG00237">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_509633_0_0_2"/>
    <dbReference type="OMA" id="IHWQSLV"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="290"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="564" mass="62070" checksum="79EC1632B7B7D1D1" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABG2</accession>
    <name>L0ABG2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233093.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1494"/>
    <dbReference type="EnsemblBacteria" id="AFZ71196">
        <property type="protein sequence ID" value="AFZ71196"/>
        <property type="gene ID" value="Calag_1494"/>
    </dbReference>
    <dbReference type="GeneID" id="14212754"/>
    <dbReference type="KEGG" id="clg:Calag_1494"/>
    <dbReference type="eggNOG" id="arCOG02113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155658_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012440">
        <property type="entry name" value="DUF1641"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07849">
        <property type="entry name" value="DUF1641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="135" mass="15112" checksum="34D7C49B20E858B7" modified="2013-03-06" version="1">MEEINEAELQTESIERLLHLVELLNNILKDEELLKAISKLLVSEETFLVVDRLPQLIKLIEKLTRQENLEKIESLLGLIESLDKETLNKLGNALSAIKNKEVKPMSLSGLITSLSQPEVSKGLNLMLNLLKALGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABI1</accession>
    <name>L0ABI1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfate adenylate transferase</fullName>
            <shortName evidence="7">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sat</name>
        <name evidence="10" type="ordered locus">Calag_1057</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="7"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232676.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1057"/>
    <dbReference type="EnsemblBacteria" id="AFZ70779">
        <property type="protein sequence ID" value="AFZ70779"/>
        <property type="gene ID" value="Calag_1057"/>
    </dbReference>
    <dbReference type="GeneID" id="14212317"/>
    <dbReference type="KEGG" id="clg:Calag_1057"/>
    <dbReference type="eggNOG" id="arCOG04191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022950_1_1_2"/>
    <dbReference type="OMA" id="LQHMIIR"/>
    <dbReference type="OrthoDB" id="15586at2157"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00066">
        <property type="entry name" value="Sulf_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020792">
        <property type="entry name" value="SO4_adenylyltransferase_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_2" evidence="9">
        <location>
            <begin position="4"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase" evidence="8">
        <location>
            <begin position="167"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="381" mass="44268" checksum="BB703BC575E68D06" modified="2013-03-06" version="1">MVSKPHGGRLIDRTRTGKSLERLQEDSEKMLKINVNEGRAYDIENIAHGVYSPLEGFMGYNDYESVLKNMRLENDIPWTIPIILDVDNNDIANIKEGDEVVLSYNNINIAILRVEEIFSWDKKEYAYYIYKTKSVEHPGVEKIYNRKDKIISGPITLLRDIPEIYENVRLFPKDTRVLFDHLNMKNIAAFQTRNAPHMGHEYVMKAALTFVDGLFINPLLGWKKKGDFVDDVIVNSYKALLNNYFPKDSYVFSILRMEMNYAGPKEAIHHAIIRKNFGATHIIIGRDHAGVGDYYAPYESWRIFEEFPDLGITPLFIREAFYCKKCKTMTNDKICPHSDEDRIKISGTQIRNLIMKGERPSEYIMRPEVVDVILSYKNPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABI3</accession>
    <name>L0ABI3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232308.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0659"/>
    <dbReference type="EnsemblBacteria" id="AFZ70410">
        <property type="protein sequence ID" value="AFZ70410"/>
        <property type="gene ID" value="Calag_0659"/>
    </dbReference>
    <dbReference type="GeneID" id="14211919"/>
    <dbReference type="KEGG" id="clg:Calag_0659"/>
    <dbReference type="eggNOG" id="arCOG00084">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1574897_0_0_2"/>
    <dbReference type="OMA" id="ERMSECP"/>
    <dbReference type="OrthoDB" id="140520at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="169" mass="19031" checksum="E973C59F87295805" modified="2013-03-06" version="1">MLSKGDLSLCPNLIAVSLPNKKSWAFEEISDTIFEKDPNAYILESKYNGVFLIYLKENNIDAIMKNVLAYQHAFLSRIVPVKSCGNDLKYVIENSLLILPKGFIKLIVHLREPLKNVIKENEISDLIISYGYKLTKKSSNALILESIDEIFVSTSGIIRKCGPSCITVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABI9</accession>
    <name>L0ABI9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233160.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1565"/>
    <dbReference type="EnsemblBacteria" id="AFZ71263">
        <property type="protein sequence ID" value="AFZ71263"/>
        <property type="gene ID" value="Calag_1565"/>
    </dbReference>
    <dbReference type="GeneID" id="14212827"/>
    <dbReference type="KEGG" id="clg:Calag_1565"/>
    <dbReference type="eggNOG" id="arCOG01978">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041129_0_0_2"/>
    <dbReference type="OMA" id="DMIDLGM"/>
    <dbReference type="OrthoDB" id="58231at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005236">
        <property type="entry name" value="Dihydropt_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025595">
        <property type="entry name" value="DUF4346"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14251">
        <property type="entry name" value="DUF4346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00284">
        <property type="entry name" value="TIGR00284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4346" evidence="1">
        <location>
            <begin position="423"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="493" mass="54765" checksum="9E2615D773D15AA5" modified="2013-03-06" version="1">MKIAVLTSTTAEEMVKDIVTNDNKHGYNIEVVPLPVPVISILDTNTISKIISRRKDILEKIRDSNLVMIPGLVRGDSSIIEKVANVETYKGPKSLGILPYALDFIHNGGKLDKQKSAEEVMGSITPKISYKTAFKIDNIEIPIRGPPVLIVAEIHPNTKVDEVESLAKRYVNDGAKIIIIGSNLESDPSVIEKKIKIASNYAPIIAEISDISLINRYRQAGIVGISTSAHLIEKDLEDIPNDLVLIIGDRNITKLKKVGSELLSKGYKLIIDPVLGIPCIDFVKSINRYTKIIKSLNAPILFSAADVTEELEADTIGIHSLLATISIELRASLYLVVEETYKSHRGVAEAREALRVAETAYSLKSTPRGLFSKLLVVKQNEKPITINDQLNYEYVNYIPPDYNLNDYIQISVDYEKNEIKVVYKRNNKILAALKGKHAMSLARELVKRVNLSLDHAAYLGYELSKAEIALKLGKTYIQDESIIIPPWMGENGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABM3</accession>
    <name>L0ABM3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lhr-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1568"/>
    <dbReference type="EnsemblBacteria" id="AFZ71266">
        <property type="protein sequence ID" value="AFZ71266"/>
        <property type="gene ID" value="Calag_1568"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1568"/>
    <dbReference type="eggNOG" id="arCOG00557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_0_0_2"/>
    <dbReference type="OMA" id="VVDEWHE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045628">
        <property type="entry name" value="Lhr_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19306">
        <property type="entry name" value="Lhr_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="33"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="270"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="875" mass="100391" checksum="123CACEB6F6F6FB8" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABM4</accession>
    <name>L0ABM4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoVT / AbrB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1102"/>
    <dbReference type="EnsemblBacteria" id="AFZ70824">
        <property type="protein sequence ID" value="AFZ70824"/>
        <property type="gene ID" value="Calag_1102"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1102"/>
    <dbReference type="eggNOG" id="arCOG00319">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069302_1_0_2"/>
    <dbReference type="OMA" id="TINTARG"/>
    <dbReference type="OrthoDB" id="38423at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="335" mass="37906" checksum="120FC94E644F53A7" modified="2013-03-06" version="1">MSFLTELEDMEENEKVVMRKVQKLGTSSMIITIPRSWARKHRISVGSLVSVYEDGDRLIISPNNEGSVLKATFSTQHNNVCKHAGRIILCSYISGLDSIILYSNRPFRNDVMEKVSEVVEKLPYTESGLLSEYEFVINFKEKPVNVVDTLLIYGRSLSSLLSKLAAHLDGAKLIKSELESNYEEMKFYSYKLLRLASKGHGQSLNEEHINRLLAAAVGLLILTNDSLYKFAIDLLNLSDFLDNEEKERIKFLLQLLEVSIVASTSSINPPSIKKEEEAYWKLKAILELENDLKDIIANTSGTFGYLLSTLINIARIINNVEETLLCYSIFSKYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABP8</accession>
    <name>L0ABP8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM additional 4Fe4S-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0725"/>
    <dbReference type="EnsemblBacteria" id="AFZ70470">
        <property type="protein sequence ID" value="AFZ70470"/>
        <property type="gene ID" value="Calag_0725"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0725"/>
    <dbReference type="eggNOG" id="arCOG00940">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_0_2"/>
    <dbReference type="OMA" id="IVWNFTN"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034391">
        <property type="entry name" value="Cmo-like_SPASM_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01387">
        <property type="entry name" value="BtrN-like_SPASM_domain_contain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="136"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="507" mass="56675" checksum="59B7DA37870656DD" modified="2013-03-06" version="1">MSMDADYYLDKVDNKKGDIGHLLAGIRLLFNNPATKSMLRIATRDVKVKYENGEVKEAPLIYHALSKFVGENISECPLSARFLIPIIDNIIKFGIEMLNGDIEATKKGISDPAIRRGVALVMKGIGLYGVTVPQKMPAPFLIVWNMTNMCNLKCMHCYQRAGKPTPDELTLEEKLNLIDQLDKAGVASIALSGGEPTIHPDYYTIVKEISRRGIHTGTATNGWLFSNINYLVKAKESGLRYVEVSLDSADPKKHDKFRGVDGSWERAVKALENAVKLGMDHGMAVTITKLNYNEVKDLLDLAEEIGVKRVIFFNFVPTGRGKENLWLDLDPVEREKFMRYIYSEMKKREGIQIVSTAPQYGRIALIMSQGKEIAPTHFAVSGDPIVKAVAEFVGGCGAGRIYAAIQPNGDVAPCVFLPLTVGNIRQESFWKIWTTSKVFNDLRDRSKLKGFCNVCPYKNICGGCRARAYGYYNDYLAPDPGCIYNVKDWNKLKQETHVKLKEEIAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABS6</accession>
    <name>L0ABS6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum cofactor synthesis domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232776.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1157"/>
    <dbReference type="EnsemblBacteria" id="AFZ70879">
        <property type="protein sequence ID" value="AFZ70879"/>
        <property type="gene ID" value="Calag_1157"/>
    </dbReference>
    <dbReference type="GeneID" id="14212417"/>
    <dbReference type="KEGG" id="clg:Calag_1157"/>
    <dbReference type="eggNOG" id="arCOG00217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00230">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_3_0_2"/>
    <dbReference type="OMA" id="IEAKTHS"/>
    <dbReference type="OrthoDB" id="51611at2157"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12727">
        <property type="entry name" value="PBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="189"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="649" mass="71492" checksum="57AADA84099E601A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABT2</accession>
    <name>L0ABT2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">2-(3-amino-3-carboxypropyl)histidine synthase</fullName>
            <ecNumber evidence="3 6">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_1163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DPH1/DPH2 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232781.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1163"/>
    <dbReference type="EnsemblBacteria" id="AFZ70884">
        <property type="protein sequence ID" value="AFZ70884"/>
        <property type="gene ID" value="Calag_1163"/>
    </dbReference>
    <dbReference type="GeneID" id="14212423"/>
    <dbReference type="KEGG" id="clg:Calag_1163"/>
    <dbReference type="eggNOG" id="arCOG04112">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037146_0_0_2"/>
    <dbReference type="OMA" id="PGQVLGC"/>
    <dbReference type="OrthoDB" id="87520at2157"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022428">
        <property type="entry name" value="Dph2_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="PTHR10762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03682">
        <property type="entry name" value="arCOG04112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="345" mass="39379" checksum="43DD279E04B9A2DA" modified="2013-03-06" version="1">MSKNFDCGIPYTLVFPDINIEGKRVLLQLPDGMKQFALAIANCIRENYKAEPIIHMESIYGACDLQYNQIFNIINPDLIIHIAHSEYPEYLASPLALPSNLRDRVVFVRALSKLDIDENMIEKSLSILDTYNVKNLSIALTAQHTHLYNKILNIIGNNSKYNIIKSNGLSPYYDPGQIIGCDFRTVINKNIDGYIFVGGGEFHPLGLYLSTLKPIAQIDLYSNTVRDFTQIGIKYYKKRLFVISKAMEARHWGVIIGLKTGQYRPSLLNMIIKMLNKKEYVLLTSENMSELNLLSIDNDWFDAFVITSCPRIPIDDLMDYKKPVLTPGEAYMALTGKIDKYIFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABU5</accession>
    <name>L0ABU5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase (NDP forming)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232801.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1184"/>
    <dbReference type="EnsemblBacteria" id="AFZ70904">
        <property type="protein sequence ID" value="AFZ70904"/>
        <property type="gene ID" value="Calag_1184"/>
    </dbReference>
    <dbReference type="GeneID" id="14212444"/>
    <dbReference type="KEGG" id="clg:Calag_1184"/>
    <dbReference type="eggNOG" id="arCOG01338">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01340">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007415_3_1_2"/>
    <dbReference type="OMA" id="EDFEHMF"/>
    <dbReference type="OrthoDB" id="2789at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="711" mass="78774" checksum="06A750E8044BD2DF" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABU7</accession>
    <name>L0ABU7_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isopentenyl phosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0846</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33963"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isopentenyl phosphate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.26" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232484.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0846"/>
    <dbReference type="EnsemblBacteria" id="AFZ70587">
        <property type="protein sequence ID" value="AFZ70587"/>
        <property type="gene ID" value="Calag_0846"/>
    </dbReference>
    <dbReference type="GeneID" id="14212106"/>
    <dbReference type="KEGG" id="clg:Calag_0846"/>
    <dbReference type="eggNOG" id="arCOG00860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070213_0_0_2"/>
    <dbReference type="OMA" id="HHNASEH"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102043">
        <property type="term" value="F:isopentenyl phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024192">
        <property type="entry name" value="Fosfomycin_R_FomA-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF1">
        <property type="entry name" value="PTHR43654:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016496">
        <property type="entry name" value="Kin_FomA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="244" mass="26726" checksum="DEAC8611404511B8" modified="2013-03-06" version="1">MGCNKVVIKLGGSLITDKSNPHTVNWESLNDVIDQIARFHNKYDSKIVLVHGGGSFGHYEVERIKKNKSIIDKVATSEIQESMLTLALAVIKLLVNSGIPASLHPAHTICNTNNAKNCNYMPIIRDLNNGLIPVTYGDAIFDNEGKIISGDDLSVEISNIINSDCLFFATDVEGILDEKGNLIKEVNKNYKITIINRAQFDVTGGIISKINKAFNSKSSNIRILSGKKLFNALIGEDVGTRIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABX0</accession>
    <name>L0ABX0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="7">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpS</name>
        <name evidence="9" type="ordered locus">Calag_0804</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="7"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232442.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0804"/>
    <dbReference type="EnsemblBacteria" id="AFZ70545">
        <property type="protein sequence ID" value="AFZ70545"/>
        <property type="gene ID" value="Calag_0804"/>
    </dbReference>
    <dbReference type="GeneID" id="14212064"/>
    <dbReference type="KEGG" id="clg:Calag_0804"/>
    <dbReference type="eggNOG" id="arCOG01887">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032621_3_0_2"/>
    <dbReference type="OMA" id="SIYHRFM"/>
    <dbReference type="OrthoDB" id="33997at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_A">
        <property type="entry name" value="Trp_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020653">
        <property type="entry name" value="Tryptophan-tRNA-ligase_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="83"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="260"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="376" mass="42894" checksum="63C6269105CDE1AF" modified="2013-03-06" version="1">MSEKNEIKLDPWGRPDIKDYSRLYDLFGIRPFNEVIDRMKKDNIELSPFIKRGIIFGHRDFDSKILKAIENKEKVAAMTGFMPSGRFHFGHMMTGLELIYFQKLGFKIFVGLADAEAYAVRHLPRKDLIRIGIEEYVANLIALGLDPKETEFYFQTNRKGSYHSLIQLFSSKITFNELEAIYGDITPGKIVSALTQAADILHPQLPEYGEYKHVVVPVGADQDPHLRLTRDLADRFKGDLDLEPPASIYHRLIRGLDGGKMSSSKPDVTIFLTDPIDQAKKKFMSSLTGGRNTAEEQRRLGGEPEKCPVYDLYLYHLVPDDVELTDIYKRCKSGSMLCGECKLFGSARLEKFLTEHQKKLEKAKDIAWSIVEIPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-04-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABZ0</accession>
    <name>L0ABZ0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0824"/>
    <dbReference type="EnsemblBacteria" id="AFZ70565">
        <property type="protein sequence ID" value="AFZ70565"/>
        <property type="gene ID" value="Calag_0824"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0824"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_4_2"/>
    <dbReference type="OMA" id="SEICLIT"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="142" mass="15144" checksum="BDF000557CA649B2" modified="2013-03-06" version="1">MYKKILVGYDGSEGGERALSKAVELGKVLNSEICLITVVPPASAIVGEIVSPDVINSAAIIDSTKKKLSEISNKLLSEGFNAKYEVLSGDPADAILNYAETHNCDLIVLGRRRLSRFERLILGSVTSKVAGKTTKADVLVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC02</accession>
    <name>L0AC02_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232544.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0912"/>
    <dbReference type="EnsemblBacteria" id="AFZ70647">
        <property type="protein sequence ID" value="AFZ70647"/>
        <property type="gene ID" value="Calag_0912"/>
    </dbReference>
    <dbReference type="GeneID" id="14212172"/>
    <dbReference type="KEGG" id="clg:Calag_0912"/>
    <dbReference type="eggNOG" id="arCOG01397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055387_2_0_2"/>
    <dbReference type="OMA" id="CERYVEH"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="351" mass="41055" checksum="E7E981FF130407FA" modified="2013-03-06" version="1">MNNQSISVLVTAYKRKEYLLDALKSLKDQTLDENKFEVIVIKNFEDPKIDSFIDCMNWKNIIPETADLGLKYEIGIKEAKGQIITFLEDDDVYESNRLQYIYSTFQKYNDLIYFHNNQKIINENGNIIDQNMIYPDIYIQDPSRYCDKLFINPGGFHNASSIAIAKEIIERKESLNLLKTIKSSPDLAMLSLAIKQKGSLYLSGQSLTRYRIHMSSSTPHGYVYRKDFKKSLITLAETYNKWAVDARKIIDYTNNIPCIDYIKPYELIRRIEASSTPSWAIKNRPISSFYDFLILYKLGKEHKFIGDKKLLAVLFLDIIVSKLPSELRELYWRIRWVSKNNLALFKRKTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC07</accession>
    <name>L0AC07_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0920"/>
    <dbReference type="EnsemblBacteria" id="AFZ70652">
        <property type="protein sequence ID" value="AFZ70652"/>
        <property type="gene ID" value="Calag_0920"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0920"/>
    <dbReference type="eggNOG" id="arCOG01410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_1_2"/>
    <dbReference type="OMA" id="AIVFPSH"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="189"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="376" mass="43456" checksum="986485F3B93F9A3B" modified="2013-03-06" version="1">MQNLKIYHITHTYYPNIGGLENVINKLSKAQTKLGHEVYIVAPKIGNNAYFDDENVLRIKYFKLGYNDLSFPLEDTLNKIKDADIIHAHSHSSYFNISIIKKAKKKGLKTALYYMAVDSLRDHPNPIIRNVGFLYARYLTKTSFNYTDLKLSRSKRDIEILKKNYGINDVHYLPDAIDEKIMTMPSHEEEFRKKFNIYNENIFVYVGRMHYLKGIEILLKAIPHVINEVKDLKILLIGPGDNRRFVKLAKKLNIQNYVEFLGFLDEELKYGAIDSSIALVLPSLSDHVEVYSVVVSESWARKKAVITTNVGELSYRIKNMENGILVKPYDPIDIANAMLLLIQDSNLRKKLGENGHKEIKTWDKIAQESIRLYKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC20</accession>
    <name>L0AC20_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232564.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0936"/>
    <dbReference type="EnsemblBacteria" id="AFZ70667">
        <property type="protein sequence ID" value="AFZ70667"/>
        <property type="gene ID" value="Calag_0936"/>
    </dbReference>
    <dbReference type="GeneID" id="14212196"/>
    <dbReference type="KEGG" id="clg:Calag_0936"/>
    <dbReference type="eggNOG" id="arCOG01389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062567_0_0_2"/>
    <dbReference type="OMA" id="WRIRRAQ"/>
    <dbReference type="OrthoDB" id="65802at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="52"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="359" mass="41529" checksum="8E36FF06E6C12DF5" modified="2013-03-06" version="1">MIISTILLILAISIFIIHISIPTFYYRYMLSNSKCNLKNNEDLDLDNYPLVSIIIPTYNEEKTIEEKIKDILRQDYEKDKMEIIVVDSASNDNTVNIAKKLNVKVFQQSERRGKANALNYALKNVNGDIVIITDADSSWETLDTIKKAVIYLKKFGGVTCIKKVRNNSIESTYRDLYNVLRLGESCIYSTPIAHGEFLAFRRGLIESFNEEIGADDSSSSHEISLKGERFVAVNDIICSELVPKEGYIHWRIRRAKHLIQHFSRAIRDINKVKDKGYKKILIIEYYIHLINPWLLIIALSLDLISSFLGNIISLFLIFAFFISLLSSQIRTWVIMQFLLAISQIKNFFNKEIVWKKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC42</accession>
    <name>L0AC42_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OB-fold nucleic acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0974"/>
    <dbReference type="EnsemblBacteria" id="AFZ70697">
        <property type="protein sequence ID" value="AFZ70697"/>
        <property type="gene ID" value="Calag_0974"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0974"/>
    <dbReference type="eggNOG" id="arCOG01510">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110881_2_1_2"/>
    <dbReference type="OMA" id="NEQNDVV"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="138" mass="15463" checksum="8C87CE5144C9AB51" modified="2013-03-06" version="1">MAKELKVNELAPKSAVEEISVKVIKVSEPRNVFGKDGMSHKVSDVLVGDESGTIIMTLWDNSINKVKEGETINIKNAFVSTFKGSMRLSLNKNNGSITVSEKEIENVNTGNNMSDKVVEEERRSYSSYGRKPSYRKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC81</accession>
    <name>L0AC81_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232537.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0901"/>
    <dbReference type="EnsemblBacteria" id="AFZ70640">
        <property type="protein sequence ID" value="AFZ70640"/>
        <property type="gene ID" value="Calag_0901"/>
    </dbReference>
    <dbReference type="GeneID" id="14212161"/>
    <dbReference type="KEGG" id="clg:Calag_0901"/>
    <dbReference type="eggNOG" id="arCOG07052">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192646_0_0_2"/>
    <dbReference type="OMA" id="QINDMPL"/>
    <dbReference type="OrthoDB" id="120571at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="84" mass="9780" checksum="250F5F061A7CAC42" modified="2013-03-06" version="1">MRTINKIKIDKMDACGNKSPISIMQESIKMIKNCDEKVEIEFNDYDFLVSLKYILKIMESQFKLRIEENGVRDGFISISIVPEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC89</accession>
    <name>L0AC89_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
            <shortName evidence="6">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serS</name>
        <name evidence="9" type="ordered locus">Calag_1335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1335"/>
    <dbReference type="EnsemblBacteria" id="AFZ71044">
        <property type="protein sequence ID" value="AFZ71044"/>
        <property type="gene ID" value="Calag_1335"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1335"/>
    <dbReference type="eggNOG" id="arCOG00403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_2"/>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="209"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="6">
        <location>
            <begin position="256"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="50"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="287"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="374"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ71044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="460" mass="53597" checksum="E4189E27EEF84558" modified="2013-03-06" version="1">MCKMPWSILELLRNDPDKLKESIKKRQMDTKIIDEALELDNKWRRVLTEINELRHKHNQVSSSIAKAKNDEKKKLLEEAKELRNQLENAEKELNEIEEKRDKMLRNLPNIVLDDVPIGGEEATVPIRFWGRAKVYKEYLDQFKEQTEKYGFKPDYEIIDYKPIGHADVLENVLKLGDTLKAGEVSGSRFYYLFDDIVWLDFALLFYAIDRLTSKGYTLVLPPYMLRYDIINSVIDLATFQDAIYKIDNEDLYMIATAEHPIAALYYNEELYDDELPKKYVGFSPAFRKEAGAGNRDLKGIFRVHQFHKVEQFIYSLPEDSKKYHEELIMNSEEIFQGLGLPYRVVNIASGDLGACAVKKYDLEVWMPGQGKYREMVSGSNCTDWQAYRLNIRLIRRKGMIRDYVHTLNSTGIASTRAITAILENYQQPDGSVIIPKVLRKYLEPFEKAPKDVIIPRNKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC97</accession>
    <name>L0AC97_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232557.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0929"/>
    <dbReference type="EnsemblBacteria" id="AFZ70660">
        <property type="protein sequence ID" value="AFZ70660"/>
        <property type="gene ID" value="Calag_0929"/>
    </dbReference>
    <dbReference type="GeneID" id="14212189"/>
    <dbReference type="KEGG" id="clg:Calag_0929"/>
    <dbReference type="eggNOG" id="arCOG01314">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1029037_0_0_2"/>
    <dbReference type="OMA" id="YIDEAHH"/>
    <dbReference type="OrthoDB" id="115215at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="302" mass="34701" checksum="62EBB0F60299ECFA" modified="2013-03-06" version="1" precursor="true">MISKLNIGLFISIFIIICLIIYFPTYQPFSPFNNAWDGFSLLYKNSSGIVDNPSQLSKINGILILPVQIKPNNLNLYYLNSFLNRGGTLIIVGNGSNVNYLLNGIGSSIYTYNYTVLDNVFNYNSPLFPLAIFNSSKIVLFSTSYLKNGNTLANTSFFSYIKLKNNVTYGPFSVISEQSIGKGEVIVISDQYFFTNYLIRINNHNNIELLKLKKYYIATFLLPQLPQYKMKLLILNISEIFNYPYVQVLIFALLFLISSIIYNIYPSSKEINYPKIADLIREHPDWDEKILRKILEERNNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACC7</accession>
    <name>L0ACC7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Looped-hinge helix DNA binding domain, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232976.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1370"/>
    <dbReference type="EnsemblBacteria" id="AFZ71079">
        <property type="protein sequence ID" value="AFZ71079"/>
        <property type="gene ID" value="Calag_1370"/>
    </dbReference>
    <dbReference type="GeneID" id="14212630"/>
    <dbReference type="KEGG" id="clg:Calag_1370"/>
    <dbReference type="eggNOG" id="arCOG00811">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149765_0_0_2"/>
    <dbReference type="OMA" id="GECEMIV"/>
    <dbReference type="OrthoDB" id="120382at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="61"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="142" mass="15763" checksum="EF323D232DAC40C3" modified="2013-03-06" version="1">MSSNRITGIVKVDSKGRITIPQTMRENLGIEPGMLVALLADGDKKEIVINPILSENAKVLELNVDMIDKPGSLAKVIDKLAEYKIDIISNRCTSITRREEGECTFIIDTSQSSIDVDKLKSVLESIDVVTQVRIKQFEVPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACH8</accession>
    <name>L0ACH8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232657.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1038"/>
    <dbReference type="EnsemblBacteria" id="AFZ70760">
        <property type="protein sequence ID" value="AFZ70760"/>
        <property type="gene ID" value="Calag_1038"/>
    </dbReference>
    <dbReference type="GeneID" id="14212298"/>
    <dbReference type="KEGG" id="clg:Calag_1038"/>
    <dbReference type="eggNOG" id="arCOG01278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_4_0_2"/>
    <dbReference type="OMA" id="NPYARYR"/>
    <dbReference type="OrthoDB" id="44046at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="2">
        <location>
            <begin position="261"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="396" mass="42561" checksum="70550B2B06BB21A8" modified="2013-03-06" version="1">MGRKVAIVGIGHSKFGVRNDVNIAELAWESIKQAFESSNLEPKDIQYISVSNVGGWSGEPLPAVVVSEYAGLTGKPLHRVEAACASGSSAVFNAYNAVSSGQADIAMAIGVEKMNESPTPTVVEFIGRAGNYFWEFENFGLTFPGYYALYATAYMSKYGASEEDLCQVAIKNHYYASMNPKAQFQRKIDMPTCMNSRYIAWPLKLFDSSPITDGSAAVILASEDVAKKITDSPVWIHSIGAASGSANLSKRNDFTGLEAAQLAAKMAYKKAGLETENTAKYFDAAEVHDCFTIAEIMAYEDLGFVKRGEGYKLAKEGQTYIGGLIPVNLSGGLKAKGHPIGATGESMVVELTKQLLNKADKGRQATIKNGRAISHNVGGTGHYAYVTILGLDKPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACJ9</accession>
    <name>L0ACJ9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional phosphoglucose/phosphomannose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PGI/PMI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1150"/>
    <dbReference type="EnsemblBacteria" id="AFZ70872">
        <property type="protein sequence ID" value="AFZ70872"/>
        <property type="gene ID" value="Calag_1150"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1150"/>
    <dbReference type="eggNOG" id="arCOG00052">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059687_0_0_2"/>
    <dbReference type="OMA" id="FPELNHN"/>
    <dbReference type="OrthoDB" id="55807at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05017">
        <property type="entry name" value="SIS_PGI_PMI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05637">
        <property type="entry name" value="SIS_PGI_PMI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035484">
        <property type="entry name" value="SIS_PGI/PMI_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="31"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="337" mass="37022" checksum="E660A9E5D7D5BE3B" modified="2013-03-06" version="1">MVNFSKEVEEMLSLYDSFPKQIEAGYKKGTSLENLDKKFKGIILSGMGGSGVTGDYIKTLGLNSKIDIPIEVVKGDSLPSWVNKDYLVIAISYSGNTHETLSCARQAYSLGAEVIAITSGGKLEELAKQKGSQIVSISKNYYPRTAIAELVSSTLGALKSQNINIINDNEINDAIETLKGTSRGEGLNIANSISDKDLYIISGCGPYELLANRWRQEFSENAKAVVKSEVYPESAHNDIVVWQVDQKYKPAFIMFEADKDNSLCSILTNLLENIYKKQGSTLIKIKPRGNNLFSKLIQGTLLAGYVSTYLAMRKGINPTDTSITGEYKKALEKENLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACN6</accession>
    <name>L0ACN6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233086.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1487"/>
    <dbReference type="EnsemblBacteria" id="AFZ71189">
        <property type="protein sequence ID" value="AFZ71189"/>
        <property type="gene ID" value="Calag_1487"/>
    </dbReference>
    <dbReference type="GeneID" id="14212747"/>
    <dbReference type="KEGG" id="clg:Calag_1487"/>
    <dbReference type="eggNOG" id="arCOG04219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027052_1_0_2"/>
    <dbReference type="OMA" id="IDPGTTT"/>
    <dbReference type="OrthoDB" id="9617at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007408">
        <property type="entry name" value="DUF460"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40707">
        <property type="entry name" value="PTHR40707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04312">
        <property type="entry name" value="DUF460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="435"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="658" mass="74548" checksum="D94990541AE48F6B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACP9</accession>
    <name>L0ACP9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpB</name>
        <name evidence="10" type="ordered locus">Calag_1203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232819.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1203"/>
    <dbReference type="EnsemblBacteria" id="AFZ70922">
        <property type="protein sequence ID" value="AFZ70922"/>
        <property type="gene ID" value="Calag_1203"/>
    </dbReference>
    <dbReference type="GeneID" id="14212463"/>
    <dbReference type="KEGG" id="clg:Calag_1203"/>
    <dbReference type="eggNOG" id="arCOG00865">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022916_0_0_2"/>
    <dbReference type="OMA" id="ICELRTP"/>
    <dbReference type="OrthoDB" id="8899at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005724">
        <property type="entry name" value="ATPase_A1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01041">
        <property type="entry name" value="ATP_syn_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="9">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="8">
        <location>
            <begin position="136"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="464" mass="51600" checksum="08055C1D62AA269B" modified="2013-03-06" version="1">MSSLYGIREYSKIVEIKGPLIVVEGVSKASYDEIVEVELSDGTRRRGRVLDVSKNVAVVQVFEGTTGITTTGTRVRFLGRPLELPVSEDMLGRIFNGLGEPIDNGPEIVAEEKYDINGSPINPAVRAYPEDFIQTGISAIDGMNTLVRGQKLPIFSGSGLPHNILAAQIARQATVKGEGEEFGVVFAAIGIKYDDYIFFKKFFEETGALNRVAMFVNLADEPAMIRLVTPRVALTLAEYLAYEKDLHILVILTDMTNYAEALREISSSREEVPGRQGYPGYMYSDLASIYERAGRVHGKKGSITQIPILTMPNDDITHPIPDLTGYITEGQIVLSRDLYNKGIYPPINVLMSLSRLMKEGIGPGKTRDDHASVSDQLYASYSRGVDLRSLAAVVGEESLSETDRKFLKFADSFEKKFLAQGVRENRSIENTLDLAWEILSELPEEELTNIKEEIIKKYHPKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACS2</accession>
    <name>L0ACS2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233121.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1525"/>
    <dbReference type="EnsemblBacteria" id="AFZ71224">
        <property type="protein sequence ID" value="AFZ71224"/>
        <property type="gene ID" value="Calag_1525"/>
    </dbReference>
    <dbReference type="GeneID" id="14212786"/>
    <dbReference type="KEGG" id="clg:Calag_1525"/>
    <dbReference type="HOGENOM" id="CLU_1544136_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="173" mass="19960" checksum="CDB16913E3636C54" modified="2013-03-06" version="1">MIYVCNDGSYGIIASSGTDIKEAKIIRIRPIDDASVLNIPLNNLRYKRPMWSIVLRIIIIIVYFGILIWFTSSSYKINNPTYEGTISFALIAIVIAVLSVVRRYRRNSFINPYQTCNKIDNWQKIKSVKYISKRRVGFTNFNIISLNIGNEDYTIALTDKELDRLKQQGIMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACT0</accession>
    <name>L0ACT0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232849.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1235"/>
    <dbReference type="EnsemblBacteria" id="AFZ70952">
        <property type="protein sequence ID" value="AFZ70952"/>
        <property type="gene ID" value="Calag_1235"/>
    </dbReference>
    <dbReference type="GeneID" id="14212495"/>
    <dbReference type="KEGG" id="clg:Calag_1235"/>
    <dbReference type="eggNOG" id="arCOG05807">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568170_0_0_2"/>
    <dbReference type="OMA" id="VIWNISS"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="480" mass="54080" checksum="48FA79734F200D62" modified="2013-03-06" version="1" precursor="true">MRKYWIKVTSFVLALLVLAGVILPFANAQSSSQSNQNQSNVNSTSILINITEKAINFAKSKGINTSLAESYYQQALSYYKQGNYTGAQIYLHLAMKVLAKEMESKPTTPIPNAIGIKMQLILIEKYVNSSKIFNNTFKEMIINQVNDSLNYLNQGNVPKAAQMLALIKKELMQVSISISNIAKQRVSHSIIKKVHHDVNQLNNIFMTELGNATSEFNYNLNETPILTLVERSLENNTNISVETYAHLLIALNNLENIMANKNISFVFNFTGRSKELWPLLFQLNRINDTLNAISLATSNTNISKAVSLMKESINETWYSIKEWYVGNDTIALNLINESIQNDMMAQSYLTNDMMGNGLLGISNRIYHLDLMVYNVINSSIIIGKKVEIIGFVIWNISSNSYLIVGHIISLGNYRGFMPVEEHMWQLMIVNTTNSTQINGTIYPNSLVKINGIISGKYYSIYIVNASQIIVLNEFMQNITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACW8</accession>
    <name>L0ACW8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233171.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1576"/>
    <dbReference type="EnsemblBacteria" id="AFZ71274">
        <property type="protein sequence ID" value="AFZ71274"/>
        <property type="gene ID" value="Calag_1576"/>
    </dbReference>
    <dbReference type="GeneID" id="14212838"/>
    <dbReference type="KEGG" id="clg:Calag_1576"/>
    <dbReference type="eggNOG" id="arCOG01615">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078428_1_0_2"/>
    <dbReference type="OMA" id="IFITEYK"/>
    <dbReference type="OrthoDB" id="44926at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015661">
        <property type="term" value="F:L-lysine efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005642">
        <property type="entry name" value="LysO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35804">
        <property type="entry name" value="PTHR35804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03956">
        <property type="entry name" value="Lys_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="202" mass="22144" checksum="70A1178E8F7FDED0" modified="2013-03-06" version="1">MENRFKEFLPPLGVFTSGLLLGIFVKFPIYDVETIAVYWLYILLGIIGIVIGVSFRDLLRTAIKGIRNGILLTLSVIIGDIIAGFLISLILRQGLNYSLSISLGSGWYSLIGPFVSFYNPYFGVIGFVSNLLREAYTLSLFPLIYSFFGTPSIAMGGATTMDTTLGVIIKYSGIENSSSAILQGLIITIILPFILPFTIILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACW9</accession>
    <name>L0ACW9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylyl cyclase CyaB, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1179"/>
    <dbReference type="EnsemblBacteria" id="AFZ70900">
        <property type="protein sequence ID" value="AFZ70900"/>
        <property type="gene ID" value="Calag_1179"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1179"/>
    <dbReference type="eggNOG" id="arCOG01723">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105244_2_0_2"/>
    <dbReference type="OMA" id="QHPCRDF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="PTHR21028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00318">
        <property type="entry name" value="cyaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="9"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="186" mass="21655" checksum="233920A5FA309F8A" modified="2013-03-06" version="1">MAFNLGSKNLEIEIKIKIDCNKIETIENNLKKFNAKFSGEREELDLYLNHPCKDMKENDEAIRIRYVNGKPETITYKSKRGDKNNPIKSREEIIVETKEDPMPLFSKLGFSVGVKVKKKRRYYDLDNLEFSLDFVDNLGCFIEIESKNAKEEDIIEALNKFNIKGEIITKTYADMVSEIESFHNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACX8</accession>
    <name>L0ACX8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor E</fullName>
            <shortName evidence="4">TFE</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">TFIIE subunit alpha homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Transcription initiation factor TFIIE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tfe</name>
        <name evidence="7" type="ordered locus">Calag_1283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The winged helix domain is involved in binding to DNA in the preinitiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TFE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1283"/>
    <dbReference type="EnsemblBacteria" id="AFZ70997">
        <property type="protein sequence ID" value="AFZ70997"/>
        <property type="gene ID" value="Calag_1283"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1283"/>
    <dbReference type="eggNOG" id="arCOG04270">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100097_0_0_2"/>
    <dbReference type="OMA" id="DSGWLTY"/>
    <dbReference type="OrthoDB" id="75288at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01909">
        <property type="entry name" value="TFE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016481">
        <property type="entry name" value="TF_E_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="PTHR13097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006373">
        <property type="entry name" value="TF_E_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="198" mass="23437" checksum="F460C3415C6E8788" modified="2013-03-06" version="1">MKENNNKEDSNSESQVNYINQLREFVRLLALKAETDDKMSSEILDILLKTDPERGISDEEIEGITGYRQSDVRKVLRLLYDARLATYRRGKHPETGATRYYWYIDMRSVGLAIIRRKKAVLEKLKSRLIYENNNEFYKCPKDNTRYTFDDAFEYDFICPKCGSMLELDTNEQYIDILKRRISLLEEEIKQDENKVFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD20</accession>
    <name>L0AD20_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative peptide-modifying radical SAM enzyme, AF0577 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232934.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1327"/>
    <dbReference type="EnsemblBacteria" id="AFZ71037">
        <property type="protein sequence ID" value="AFZ71037"/>
        <property type="gene ID" value="Calag_1327"/>
    </dbReference>
    <dbReference type="GeneID" id="14212587"/>
    <dbReference type="KEGG" id="clg:Calag_1327"/>
    <dbReference type="eggNOG" id="arCOG00938">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_777602_0_0_2"/>
    <dbReference type="OMA" id="FCGGRCL"/>
    <dbReference type="OrthoDB" id="18533at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023819">
        <property type="entry name" value="Pep-mod_rSAM_AF0577"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273:SF2">
        <property type="entry name" value="PTHR43273:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01104">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04084">
        <property type="entry name" value="rSAM_AF0577"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="353" mass="40876" checksum="BE161E71D7930721" modified="2013-03-06" version="1">MLWLIITTGKCNLKCDYCGGSYPNKFVPWNIKYDIEKLKELILKDNFPTVIFYGGEPLLNYKYIMNVMDNIKKARFGIQTNGLLVKLLPEEYWKRINVALLSIDGREEINDKHRGKGAYNKVINAVKYLKEINPNIETIARMTVTKDSDIYEEVMHLIKLKLFDKIHWQLDVIWDEKWDFNSWAENSYLPGLKKLMEYFLDGLRNGRLIKIIPFLGILSAHYHQGFIGYPCGAGYKSVTVSSDGRILSCPIAVRENWSVLGYVNKGFNLIKDPLPDYCKNCDLKRYCGGRCLYMHMEPYWGKEGFISVDNINKKYIKMVLSIIPEVDNLIKNGIISLDSLYYDPTLDSTEVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADF6</accession>
    <name>L0ADF6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sulfate transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233044.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1441"/>
    <dbReference type="EnsemblBacteria" id="AFZ71147">
        <property type="protein sequence ID" value="AFZ71147"/>
        <property type="gene ID" value="Calag_1441"/>
    </dbReference>
    <dbReference type="GeneID" id="14212701"/>
    <dbReference type="KEGG" id="clg:Calag_1441"/>
    <dbReference type="eggNOG" id="arCOG00164">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_14_1_2"/>
    <dbReference type="OMA" id="NEYNFVA"/>
    <dbReference type="OrthoDB" id="97465at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="51"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="266" mass="29486" checksum="2DAB19355E588386" modified="2013-03-06" version="1">MKKEINFFIILTIIFSLFFLLFFAYPLVVLIIVGSKGIISSLENESFLTAIYITFIISTSAAISAVIFGLPLGYIIARYNFRFKEVIETLIDIPIVIPHIIVGVMIVLAFSSQYGLGPIFHKYGINVIDTILGAALAVSYLSSTYTIRVVESSIKAIDPELELISRSLGASQMRTFFSVILPNIWRSVINGALLTWARATSEAGALFIVAYYVIFGKTTVYPSPVFIYESYVGLGLIEAVKFSAALVVIIVSAFILFRVIINLRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADJ7</accession>
    <name>L0ADJ7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mg-dependent DNase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233002.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1397"/>
    <dbReference type="EnsemblBacteria" id="AFZ71105">
        <property type="protein sequence ID" value="AFZ71105"/>
        <property type="gene ID" value="Calag_1397"/>
    </dbReference>
    <dbReference type="GeneID" id="14212657"/>
    <dbReference type="KEGG" id="clg:Calag_1397"/>
    <dbReference type="eggNOG" id="arCOG00891">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_5_0_2"/>
    <dbReference type="OMA" id="DGPYEYR"/>
    <dbReference type="OrthoDB" id="48998at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="243" mass="28084" checksum="E085D68AF9794131" modified="2013-03-06" version="1">MEIYDMHCHLNEFDDKEIEEIIKNDIKIVAVSEDVKSLKRILELSKSFTGKIIPCGGFHPWMIKNGNLDDHKEILNIIEKEGLNCIGEVGIDKRFLDESTYKLQEEIFISYVKLAKELNSFLNIHSPSAWNEVFVVLEKEGIEKAMFHWYTGPTSLINEITNKGYIISLNVALMIQKKHQNIIKETPLANAVVESDGPYNYHGVRLTPLMIFEFIDFISKLINVNKKELNEIFNRNSINLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADV7</accession>
    <name>L0ADV7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1536"/>
    <dbReference type="EnsemblBacteria" id="AFZ71235">
        <property type="protein sequence ID" value="AFZ71235"/>
        <property type="gene ID" value="Calag_1536"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1536"/>
    <dbReference type="eggNOG" id="arCOG00833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_0_2"/>
    <dbReference type="OMA" id="IITCIEG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017255">
        <property type="entry name" value="AcTrfase_GNAT_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037663">
        <property type="entry name" value="Acetyltransf_GNAT_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="147" mass="16890" checksum="4AACD8DD3336F481" modified="2013-03-06" version="1">MEVKIRPCTSNDMKHILSIESESFAEGERYSRSIFLYYIMFKKAILLVASIDNNIVGYSLGYMEDEEVGHIVSIAVKKAYRNNGIGTKLMESIENELKSRGAKLIKLEVSVDNNARKLYEKLGYKMIKLLPMYYGNRDGILMIKEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7I1</accession>
    <name>L0A7I1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM-dependent MTase TRM10-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231726.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0035"/>
    <dbReference type="EnsemblBacteria" id="AFZ69828">
        <property type="protein sequence ID" value="AFZ69828"/>
        <property type="gene ID" value="Calag_0035"/>
    </dbReference>
    <dbReference type="GeneID" id="14211295"/>
    <dbReference type="KEGG" id="clg:Calag_0035"/>
    <dbReference type="eggNOG" id="arCOG00967">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061952_0_0_2"/>
    <dbReference type="OMA" id="REYLWDA"/>
    <dbReference type="OrthoDB" id="79589at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="RNA_MeTrfase_TK0422/Sfm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016742">
        <property type="entry name" value="tRNA_m1G_mtfrase_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="RNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018978">
        <property type="entry name" value="tRNA_m1G_mtfrase_arc_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="4">
        <location>
            <begin position="87"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ69828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="331" mass="38016" checksum="A7282A4C7D069847" modified="2013-03-06" version="1">MDNYGYSKIGSREWLELNKISRLGFQYLATETLIREYSFIEDETYRGKEIYSEEWKGNKKIILYSDGTESADVVVSRKVNPNVKSLSWRSLLDYLPQPPLPLFVIDMSMKFIHTPEELAKLRLQIGVSLSTLREYLWDAHLAITGADEETSKWLLEVLGYNKVSISNARPSEILWGFDADKVIILRPDAPNPLKPEDVLTADAFLIGGIVDKIPRPGMSRMLDSLVPWGIPRRLELRGSVIGVPERINRIIEILLKTRYLYNGDITKAIISTMTKKDRISRAYREIIKDSKDEGGVKYVTKENYNMLKAWLPLTFDEYLEAAKRAHIEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7P9</accession>
    <name>L0A7P9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpB</name>
        <name evidence="14" type="ordered locus">Calag_0105</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231791.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0105"/>
    <dbReference type="EnsemblBacteria" id="AFZ69893">
        <property type="protein sequence ID" value="AFZ69893"/>
        <property type="gene ID" value="Calag_0105"/>
    </dbReference>
    <dbReference type="GeneID" id="14211365"/>
    <dbReference type="KEGG" id="clg:Calag_0105"/>
    <dbReference type="eggNOG" id="arCOG01432">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042858_1_0_2"/>
    <dbReference type="OMA" id="QWGMAVS"/>
    <dbReference type="OrthoDB" id="24741at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006316">
        <property type="entry name" value="Trp_synth_b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF6">
        <property type="entry name" value="PTHR48077:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500824">
        <property type="entry name" value="TrpB_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01415">
        <property type="entry name" value="trpB_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="73"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFZ69893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="422" mass="46846" checksum="0513AF1C93478D8A" modified="2013-03-06" version="1">MVGNEESLPEFWYNIIPDLPVPLSPPRDPPDGEFSRIDLLNEILPKEILRQQFTIERYIKIPDELREKYILIGRPTPLIRAKGLENALNTPAKIYFKYEGATPTGSHKINTALAQSYFALNEGIDHVVTETGAGQWGTAVSFSASLFNMKSTIFMVKVSYEQKPMRKILMNLYGGNVYASPSNLTEYGLNILKENPNHPGSLGIAMSEAIEYALKNKLRYLVGSVLDVAILHQSIIGLETMKQLEMIGENADILIGCVGGGSNFGGFSYPFIGNKIGEEYIAVGSEEIPKFSKGEYKYDFADSAGLLPLVKMITLGHNYVPPPIYSGGLRYHGVAPTLSILIKENLVKWKEYNEKEIFDAAKLFIKAQGIVPAPESAHAIRAVIEKALELKKNNEKKTIVFNLSGHGLLDLTNYDSMSKRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7Q0</accession>
    <name>L0A7Q0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase/AMP-acid ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0060"/>
    <dbReference type="EnsemblBacteria" id="AFZ69851">
        <property type="protein sequence ID" value="AFZ69851"/>
        <property type="gene ID" value="Calag_0060"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0060"/>
    <dbReference type="eggNOG" id="arCOG01529">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_2"/>
    <dbReference type="OMA" id="LIWTSPT"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="68"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="528"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ69851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="649" mass="74058" checksum="46456E9098AB9611" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7R5</accession>
    <name>L0A7R5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231811.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0125"/>
    <dbReference type="EnsemblBacteria" id="AFZ69913">
        <property type="protein sequence ID" value="AFZ69913"/>
        <property type="gene ID" value="Calag_0125"/>
    </dbReference>
    <dbReference type="GeneID" id="14211385"/>
    <dbReference type="KEGG" id="clg:Calag_0125"/>
    <dbReference type="eggNOG" id="arCOG02998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1830498_0_0_2"/>
    <dbReference type="OrthoDB" id="96291at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="74"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="140" mass="16237" checksum="3D8452A74D29D9B6" modified="2013-03-06" version="1">MTIKEKVTSDEIDIEIEREEFNVKKLTRKAEKLSFKDIITPDMTDPLAIPPLRLVSSDNLSIEFSKRRFSLPFFHRNMDYDELIICLKGSATWQTETGEFELKEGEMLIIPRGIAHRPVNPSNDYMALEIKSKNKLSFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7T8</accession>
    <name>L0A7T8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0152"/>
    <dbReference type="EnsemblBacteria" id="AFZ69938">
        <property type="protein sequence ID" value="AFZ69938"/>
        <property type="gene ID" value="Calag_0152"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0152"/>
    <dbReference type="eggNOG" id="arCOG00845">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2270908_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="102" mass="12361" checksum="E08F984A422010D2" modified="2013-03-06" version="1">MNFKEIDRVYFNDGKTMEINEIIKKYQLKQVDKIDIKIKGFIHEWVWFPFEKYNGEFYVNNDMILLETSPPFLIYNGNVEFKHNSNIRKENSEGFIVFELNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7W8</accession>
    <name>L0A7W8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231866.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0184"/>
    <dbReference type="EnsemblBacteria" id="AFZ69968">
        <property type="protein sequence ID" value="AFZ69968"/>
        <property type="gene ID" value="Calag_0184"/>
    </dbReference>
    <dbReference type="GeneID" id="14211444"/>
    <dbReference type="KEGG" id="clg:Calag_0184"/>
    <dbReference type="eggNOG" id="arCOG01423">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064028_2_1_2"/>
    <dbReference type="OMA" id="TWDENQR"/>
    <dbReference type="OrthoDB" id="103723at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024271">
        <property type="entry name" value="DUF3782"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012431">
        <property type="entry name" value="PDDEXK_10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12644">
        <property type="entry name" value="DUF3782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07788">
        <property type="entry name" value="PDDEXK_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="250" mass="29161" checksum="B1C1963B98FFA98F" modified="2013-03-06" version="1">MANESKIDLKKEIIRLLKEDENFRYEVVGLIGIEEMIKRLEKNTEEIVSLRAETNKLRQDVNLLIEEMNKLREETNSLRAETNKLRQDVNLLIEEMNKLREETNSLRAETNKLRQEMMRGFESMDIRLTALGARWGVYTEDTVKNLLKGVLEKELNYKIEKWVYNDSQGVVYGYPSIIEIDMAIIGDKILLIEFSSHIKRSDPFTFKKKAELFEKTTGKKASRLIIATPYIDQDAENACQILGIEVYSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7X1</accession>
    <name>L0A7X1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate/tyrosine/aromatic aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231829.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0145"/>
    <dbReference type="EnsemblBacteria" id="AFZ69931">
        <property type="protein sequence ID" value="AFZ69931"/>
        <property type="gene ID" value="Calag_0145"/>
    </dbReference>
    <dbReference type="GeneID" id="14211405"/>
    <dbReference type="KEGG" id="clg:Calag_0145"/>
    <dbReference type="eggNOG" id="arCOG04334">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_893125_0_0_2"/>
    <dbReference type="OMA" id="MFKWIRE"/>
    <dbReference type="OrthoDB" id="88926at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="114"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="316" mass="36689" checksum="FD77F1AA4A9034B4" modified="2013-03-06" version="1">MIQFEIGKYLEQHKVKYNLSNSGMSDVIDISKYFKGVSIISEEDLKKEIAEVNGDKAENVVITHGATEAFFLTAYYLYNKGLKKAKFPLPEYELIRKIPEALGMEIGEGDIYMLSNPNNPTGQIMELEPDYKAYIVDETFMEFYRNLDKSSYPENTFRINTFTKFYGGDELRVGYIITPSKEDAEKIDNFRGILTDRVSRYNMSVAYKILKDRENIRKTVREIQKIKLDILLNKRDKLEFFKGRIPVLGTISFMDYSNYTKIDSKELTEKLIDKSILVVPSSYFGINGPYMRVCYSSKNFEEGYGKLKEALNEFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A813</accession>
    <name>L0A813_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231869.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0187"/>
    <dbReference type="EnsemblBacteria" id="AFZ69971">
        <property type="protein sequence ID" value="AFZ69971"/>
        <property type="gene ID" value="Calag_0187"/>
    </dbReference>
    <dbReference type="GeneID" id="14211447"/>
    <dbReference type="KEGG" id="clg:Calag_0187"/>
    <dbReference type="eggNOG" id="arCOG00916">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_2"/>
    <dbReference type="OMA" id="REGLNQH"/>
    <dbReference type="OrthoDB" id="20774at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="448" mass="50633" checksum="9B9A7C40DFA90A13" modified="2013-03-06" version="1">MQDYSVKLNKDFSYSLFATWRKQKGFNPITIVDAEGSYIYTNDNRKILDFSSQLMCSNLGHKNKRVISAMIEQMNKVAYVSPSFNTPIKDEIAKELKSVLPENLVKYFFATSGTEANEAAIKIIRMIKGKEGKTKILSYYNSYHGSTSGSIQLTGDFRRIAVDSFERSPGFYHIPPPYCYRCPFNLKYPECNLACVKYAEYVFKNEGNIGGIFVEPVIGTNGVIVPPKDYLRELKKITEENDAIFVADEVMTGWGRTGEWFAVNHFGIKPDILTTAKGITGAYFPLSLTAVNKEISDYFEDNYFAHGHTYEAHPLGLAAAVAAIKEYKEKKLVENAKSLSIELGKRLEEFKEKHKSVGDVRYIGLFAAIELVKNKEKKTPFNTYNEKIEGKQLVVDKVARKALEKGVYVNTWVSHLIIAPPLIITKEELENGLDAIDEALYESDKEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8F9</accession>
    <name>L0A8F9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="10">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Calag_0368</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="10"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232041.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0368"/>
    <dbReference type="EnsemblBacteria" id="AFZ70143">
        <property type="protein sequence ID" value="AFZ70143"/>
        <property type="gene ID" value="Calag_0368"/>
    </dbReference>
    <dbReference type="GeneID" id="14211628"/>
    <dbReference type="KEGG" id="clg:Calag_0368"/>
    <dbReference type="eggNOG" id="arCOG04300">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035731_0_0_2"/>
    <dbReference type="OMA" id="YQMDYAN"/>
    <dbReference type="OrthoDB" id="31182at2157"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="338" mass="37447" checksum="2935AA858EE65E0C" modified="2013-03-06" version="1">MGSFPRIRPRRLRSSKYLRDLISETSLDISKLILPVFVSEAIEKPIETPGLEGQLTYPSDSSNLVNFISEALDLGIRSFLIFGIPKIKNEDGIRAYAPDGPVQVAIRNIRKEIGWDPLIFTDLCICEYTSHGHCGIPLNSRKGDVIDNDSTLKVYQKIAVSQAQSGSDFISPSGMMDGQVKAIREALDDAGFNDVGIMAYSVKYASAMYGPFRQAVDSAPRFGNRKSYQMDPRNAKEALKEVRLDLDEGADIIMVKPAILYLDVIRLVKEYYPEVPLAAYNVSGEYAMIRSAIKLGLIDETQSIIESLISIRRAGADMIITYFALDAAKIISSGKEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8H9</accession>
    <name>L0A8H9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232024.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0349"/>
    <dbReference type="EnsemblBacteria" id="AFZ70126">
        <property type="protein sequence ID" value="AFZ70126"/>
        <property type="gene ID" value="Calag_0349"/>
    </dbReference>
    <dbReference type="GeneID" id="14211609"/>
    <dbReference type="KEGG" id="clg:Calag_0349"/>
    <dbReference type="eggNOG" id="arCOG04779">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_1_2_2"/>
    <dbReference type="OMA" id="YSRMRWK"/>
    <dbReference type="OrthoDB" id="66502at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="200"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="222"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="171"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="306" mass="32884" checksum="B5DD688A9EB66169" modified="2013-03-06" version="1">MSEPIIVVHAGAGTWKNVEDINQIVDILKESLEAGYNSYKNGNCLDMVTSAIEVMENSGILNAGLGSTLDYVGNVTMDAGIVNGNSLKAGAVAAVTYPKNPIKLARFVLEKTPHLLIAGQYADKLAKKINLEKHPGPSKNSIYLWNKLKNNPNVENFVLERINAAKQIGYDTVGSVAIDKDGCLSAGVSTGGVSLKLPGRVGDSPIFGAGYYANKKIAVAATGIGEVIMTTLLSYKVSEIYEINGNLMESMNNVIEYINKGFGKDVVGIIGIDYKKNVYGIYNTEAMPWGYITLDKKIVIKGLPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8R5</accession>
    <name>L0A8R5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucan phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232134.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0470"/>
    <dbReference type="EnsemblBacteria" id="AFZ70236">
        <property type="protein sequence ID" value="AFZ70236"/>
        <property type="gene ID" value="Calag_0470"/>
    </dbReference>
    <dbReference type="GeneID" id="14211730"/>
    <dbReference type="KEGG" id="clg:Calag_0470"/>
    <dbReference type="eggNOG" id="arCOG01421">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_552792_0_0_2"/>
    <dbReference type="OMA" id="GWEACGT"/>
    <dbReference type="OrthoDB" id="19755at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="521" mass="60507" checksum="4F6606777023B91B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8W2</accession>
    <name>L0A8W2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231757.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0068"/>
    <dbReference type="EnsemblBacteria" id="AFZ69859">
        <property type="protein sequence ID" value="AFZ69859"/>
        <property type="gene ID" value="Calag_0068"/>
    </dbReference>
    <dbReference type="GeneID" id="14211328"/>
    <dbReference type="KEGG" id="clg:Calag_0068"/>
    <dbReference type="eggNOG" id="arCOG03665">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006754_0_0_2"/>
    <dbReference type="OMA" id="DYYFALG"/>
    <dbReference type="OrthoDB" id="307at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017001">
        <property type="entry name" value="Pept_S53_physarolisin-II_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032623">
        <property type="entry name" value="Peptidase_SSO2181_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1369"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="8">
        <location>
            <begin position="224"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ69859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="1397" mass="151012" checksum="F5A7EB3E07E28C05" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8X6</accession>
    <name>L0A8X6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PRPP-binding protein, adenine/guanine phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232236.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0580"/>
    <dbReference type="EnsemblBacteria" id="AFZ70338">
        <property type="protein sequence ID" value="AFZ70338"/>
        <property type="gene ID" value="Calag_0580"/>
    </dbReference>
    <dbReference type="GeneID" id="14211840"/>
    <dbReference type="KEGG" id="clg:Calag_0580"/>
    <dbReference type="eggNOG" id="arCOG00031">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086256_1_0_2"/>
    <dbReference type="OMA" id="KGYHQAS"/>
    <dbReference type="OrthoDB" id="97021at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="96"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="230" mass="25353" checksum="C4C362938B976FD7" modified="2013-03-06" version="1">MPQQNYEERLRAVKILRSARKFLSLSKISELTGLSLSIISRYSSEYTLPSEGNAREIINSLLSKQIISNIVANAIKVYNGFYDISGVTWNPDALLLISEYVKKRFNGNFDRILTPEAGGISLATSISISSGVPMVVAKKQRPISSEPIIEGVHFYGPASYTVFYVPKRELPKGGKILIVDDFSVRGHTLNALIELIRKAGAEPRSMLVIVGIGKDWKLLPDSEALIEISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Y7</accession>
    <name>L0A8Y7_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232224.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0567"/>
    <dbReference type="EnsemblBacteria" id="AFZ70326">
        <property type="protein sequence ID" value="AFZ70326"/>
        <property type="gene ID" value="Calag_0567"/>
    </dbReference>
    <dbReference type="GeneID" id="14211827"/>
    <dbReference type="KEGG" id="clg:Calag_0567"/>
    <dbReference type="eggNOG" id="arCOG01601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058423_0_0_2"/>
    <dbReference type="OMA" id="EYAIPTP"/>
    <dbReference type="OrthoDB" id="29720at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="47"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="314" mass="34589" checksum="91188071FB36E97C" modified="2013-03-06" version="1">MPVRLADFPRVRYGMPGNAACPGCPETMGLRYVKMALGDNVVLVIPAGCSSVIQGYTPKSGINFPILNIVFASASSAAAGMEAAFEAQGKDATVVVWAGDGGTGDIGFQAMSGAAERNDNILYICADNEAYMNTGIQRSSLTPFGAWTTTTWTGKTEYKKNIPMIMIAHDVPYVATATVGYPQDFIDKLRKASKIKGFKYIHLLAPDPVGWKFDPSLTAKLGQLAVQTGLFPLFEYENGKLTVSVFSRLYRRPEKRVPIIEYIKVQGRYANLMKDPEKIKKLEEEIERQWKWIDILEKSSNPSNVASQAIKENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A913</accession>
    <name>L0A913_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231812.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0126"/>
    <dbReference type="EnsemblBacteria" id="AFZ69914">
        <property type="protein sequence ID" value="AFZ69914"/>
        <property type="gene ID" value="Calag_0126"/>
    </dbReference>
    <dbReference type="GeneID" id="14211386"/>
    <dbReference type="KEGG" id="clg:Calag_0126"/>
    <dbReference type="eggNOG" id="arCOG00857">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_2"/>
    <dbReference type="OMA" id="TVPMVYD"/>
    <dbReference type="OrthoDB" id="13052at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="429"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ69914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="498" mass="56431" checksum="1693401975450743" modified="2013-03-06" version="1">MSQIIFLDKPIFSFLDSISNEKPNECALIQMENNHCITWNYLKEASNKIANWINSTNKNNQVLFACHNTIDSVVGLIGIMKSGSPAALVDPLTISEDLKQEIEGKNIKTAVVSWQFFEREKETLKQEGIDNVLIVDGQVKEEGNLNVNYIKDVLSTNETYENKELNLDDISIIMYYAGVAGRTMQTYHTHRGLSYAVQALSKTINFDFVPNSLVISPITHVLGLQVSLLTPLYNKGKAIMISRWDANLAMKTIKYYNINFMSGAPLVFDSLIDAIEKSNEDFKNTLKLGISAGAPLKPETQDKFYKVFASPLVQAYGMTETWVVSYQPKEFFEIKNTLGLPLYGVEIKVVSPDDPSEELGKNQAGELLVKASWVMKGYEDDNETKKAFYNGYLKTGDLVLIDDKGFLYFKGVKKRMLKYKAYPIFPKDLETILLKHYAVKNAFVFGEKDPDVGDLPVAKVVLKDEYKGKIKEEELINYVNSRVAFYKKIRKIYFVDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A914</accession>
    <name>L0A914_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232281.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0628"/>
    <dbReference type="EnsemblBacteria" id="AFZ70383">
        <property type="protein sequence ID" value="AFZ70383"/>
        <property type="gene ID" value="Calag_0628"/>
    </dbReference>
    <dbReference type="GeneID" id="14211888"/>
    <dbReference type="KEGG" id="clg:Calag_0628"/>
    <dbReference type="eggNOG" id="arCOG05960">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_982119_0_0_2"/>
    <dbReference type="OMA" id="IFINSEW"/>
    <dbReference type="OrthoDB" id="125979at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="281" mass="32336" checksum="7E1945B5D36C3D1A" modified="2013-03-06" version="1">MQYNELKNNLIKAIDVAKSMKKPEIEDNILIISDYISRSAGKILYIGLLSSGKKATLLTPTEAVLYSLPYYENFNKTIIFSMNPKDSRSVHAAEVSRVMNLEVEFISPKLDDTLEERLKYLGVKRIFINSEWPIITSSIASLLWIPKDLGERYERIKKEMDNLEGALDWLNEKYKSNIERIKKINEEFAIFYTPSTEAGGIYAYNILQNCAFALPIEFLKNKIKYRKILLTSSVDSSDFKDLIIMFKIDYTGNELIEFNTDPITVGLYSMLFISLISDKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9B1</accession>
    <name>L0A9B1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0716</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232359.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0716"/>
    <dbReference type="EnsemblBacteria" id="AFZ70461">
        <property type="protein sequence ID" value="AFZ70461"/>
        <property type="gene ID" value="Calag_0716"/>
    </dbReference>
    <dbReference type="GeneID" id="14211976"/>
    <dbReference type="KEGG" id="clg:Calag_0716"/>
    <dbReference type="eggNOG" id="arCOG00951">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048071_0_0_2"/>
    <dbReference type="OMA" id="CIFCSVD"/>
    <dbReference type="OrthoDB" id="68339at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040088">
        <property type="entry name" value="MJ0103-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11228:SF35">
        <property type="entry name" value="PTHR11228:SF35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01110">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="37"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="351" mass="40123" checksum="5E47E4DFF442D9D4" modified="2013-03-06" version="1">MKCNAKIEKISNFYGRPIYYINKPIPLIGHIAFGIIDRGTNVLQVRPSTLCFHNCIFCSVDAGPNSKFRESEYIVNEEWLAEWVNDVANVKNEDIEVLIDGVGEPISHPKILKLISLIKKIKNVKTISIETHGGSLSLQLAKKLEEAGLNRINLSIDSINSENAKKLSGTEWYDVNKILKNASEILKETNIDIVLTPVVIPEINEKDMDLIIEWAKENHAGEKSNYPSGILIQKFEIHHFGRKPEKIKVWSWGKFYSWLKILQEKHNYRLIVKPEELGFKDSAKLEKPFHVNDIVKSTIIGNGWLKNEYLATDENCIRIISIISKEDLMIGSKVKTKIIRDKDNIFLGKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9D2</accession>
    <name>L0A9D2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232378.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0737"/>
    <dbReference type="EnsemblBacteria" id="AFZ70481">
        <property type="protein sequence ID" value="AFZ70481"/>
        <property type="gene ID" value="Calag_0737"/>
    </dbReference>
    <dbReference type="GeneID" id="14211997"/>
    <dbReference type="KEGG" id="clg:Calag_0737"/>
    <dbReference type="eggNOG" id="arCOG04105">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140139_0_0_2"/>
    <dbReference type="OMA" id="QYLLYYM"/>
    <dbReference type="OrthoDB" id="125172at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="171" mass="19253" checksum="AF4104B74B06B288" modified="2013-03-06" version="1">MGGRKQNKLKEEQVDQKASTTKDIKVVATQVITKDRVIQNPKLLSLLYLISQLGMVHERTLQIVVAELKNKGVDLGYQFSQLGNDPYSAALKNDIVALLYTGLAEAEPRYRKIRVTGDGKEVLEKADSIKPFQDSLNKILNEIKNKASMVDAEIDFEIRKVNKLSAKKIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9M1</accession>
    <name>L0A9M1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor TFIIIB, Brf1 subunit/transcription initiation factor TFIIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231740.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0050"/>
    <dbReference type="EnsemblBacteria" id="AFZ69842">
        <property type="protein sequence ID" value="AFZ69842"/>
        <property type="gene ID" value="Calag_0050"/>
    </dbReference>
    <dbReference type="GeneID" id="14211310"/>
    <dbReference type="KEGG" id="clg:Calag_0050"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_917028_0_0_2"/>
    <dbReference type="OMA" id="NEYVCTR"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="311" mass="35053" checksum="C139A5D06617C70F" modified="2013-03-06" version="1">MKCPRCSSDNLVTTIDGKLVCQNCGLVVDENLLADRPEWRSYNEKGIQNTKGVERASQPETLLRHDKGSGALVFTPPKSRNLLKSFNSRRISMRHATSRSEMPQIAMFSLANKLSEYFNLPRSASQTLGLILHEYIEKNGGSVGKYKEAIIAAAFAKVVELYNLNISQSEIEEFMEIDSNKLWEGKKKLNDLGILSKYRFIESENMGYTDSKDRMLTRVVTYINRIVSSLNLNQTIIEQSISFVKESLSSGKTLYGKKPEAIAAATVYLISRLNGHDISQKEIAETVSIKESTVRKLYKFLITNMSIVVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9M8</accession>
    <name>L0A9M8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232002.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0327"/>
    <dbReference type="EnsemblBacteria" id="AFZ70104">
        <property type="protein sequence ID" value="AFZ70104"/>
        <property type="gene ID" value="Calag_0327"/>
    </dbReference>
    <dbReference type="GeneID" id="14211587"/>
    <dbReference type="KEGG" id="clg:Calag_0327"/>
    <dbReference type="eggNOG" id="arCOG01606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_1_0_2"/>
    <dbReference type="OMA" id="YYQRGGP"/>
    <dbReference type="OrthoDB" id="41678at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="6">
        <location>
            <begin position="15"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="7">
        <location>
            <begin position="254"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="8">
        <location>
            <begin position="523"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="640" mass="71089" checksum="22808BC03DBEBBE5" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9M9</accession>
    <name>L0A9M9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0840"/>
    <dbReference type="EnsemblBacteria" id="AFZ70581">
        <property type="protein sequence ID" value="AFZ70581"/>
        <property type="gene ID" value="Calag_0840"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0840"/>
    <dbReference type="eggNOG" id="arCOG02271">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101251_1_0_2"/>
    <dbReference type="OMA" id="GAYSAIY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH bat-type" evidence="1">
        <location>
            <begin position="142"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="213" mass="24425" checksum="01E608919692491E" modified="2013-03-06" version="1">MIKLVYLTKAKIKIYRDDCEVTNEIYEKGLRFKHLKVKPGIDESVHIIKFEKPIEKETLKGFKNVFELNEYTILVTAKSCSACKLMSLVNLLILSAEPDSNNSITYTVLAKSNQLNEAIEKFKESGLRVEIISKERPKNTDLSQKQIRAVLTAYKMGYFCKDRKATLTEVANSLNVKPSSLEDVLRKGLEKILTSYFLDQGLIDEDDVEIYWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9N8</accession>
    <name>L0A9N8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thermopsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231760.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0071"/>
    <dbReference type="EnsemblBacteria" id="AFZ69862">
        <property type="protein sequence ID" value="AFZ69862"/>
        <property type="gene ID" value="Calag_0071"/>
    </dbReference>
    <dbReference type="GeneID" id="14211331"/>
    <dbReference type="KEGG" id="clg:Calag_0071"/>
    <dbReference type="eggNOG" id="arCOG03670">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_671937_0_0_2"/>
    <dbReference type="OMA" id="RWIAVIN"/>
    <dbReference type="OrthoDB" id="12325at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007981">
        <property type="entry name" value="Peptidase_A5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05317">
        <property type="entry name" value="Thermopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="415" mass="47732" checksum="F60C858B82373161" modified="2013-03-06" version="1" precursor="true">MKKYLIIFIIIMFSFLTLNIAKSTSVGINDNGTIITNNGTFQYGYSTNGLLGIFNFYNGSFYSANPNFINGYSLQLNANVNISLNTTLWVQSISRVIKENNTYKINFLDNVWNVTTSNSSISLINGKGSIYNNYYAYEFPITFTSITPFSIKIYDYIIGNSTYPRFLVYFIFENSTYKTNKILLDNITVNIKSRNPRFLIGNMGGFAPETVNSLYYPFVLQFVICGFSRGSQLFVYKWNSTMQLFYLYNNSWYFIPSAFQDSPNYYAGSVTLESVNQLDGINEHYNNDVIYQTQGMLNQTSLWIPGIKIINNSNNYILIFIPQTLWNVTIKNNHIENFRGNESNITLSHGYYLIKAILVVDNKPILTYMFNLTQINKSSSSYSFPSEIQSLLYLAIFVVILMIFASIIKRIKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9S8</accession>
    <name>L0A9S8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0866"/>
    <dbReference type="EnsemblBacteria" id="AFZ70606">
        <property type="protein sequence ID" value="AFZ70606"/>
        <property type="gene ID" value="Calag_0866"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0866"/>
    <dbReference type="eggNOG" id="arCOG04144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085935_0_0_2"/>
    <dbReference type="OMA" id="VKMFGYA"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015254">
        <property type="entry name" value="AGOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09171">
        <property type="entry name" value="AGOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="287" mass="33441" checksum="8467CD4B27FFAA72" modified="2013-03-06" version="1">MVKLNINNERLIKVSDSIKNFGLDNVLILEEKLDPQFDYIQKLKEKVGKNYATIYSLLVSLISYKLTMKGEDWWKCFSEYLSAKDIPKNFEESINNVINFINDCKGSIIGRAAKIKRIEKVVKGSRDILLEILERPEVVLEKPNKILEEIAKSLNSKEWKKTITFSIKMSYYAIKNRGELRPLNIVIPMPIDVRISCISYTSGIIESNSYKEILKKPKIAIEAWDKVSQLSNIPQIHLDSLLWIIGRNSMELSLDEAKENAKRILMKYFDKDKVDYLLYNLFYRECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9U1</accession>
    <name>L0A9U1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0124"/>
    <dbReference type="EnsemblBacteria" id="AFZ69912">
        <property type="protein sequence ID" value="AFZ69912"/>
        <property type="gene ID" value="Calag_0124"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0124"/>
    <dbReference type="eggNOG" id="arCOG01107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_2_2"/>
    <dbReference type="OMA" id="STFEPTM"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010182">
        <property type="entry name" value="ArgE/DapE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01910">
        <property type="entry name" value="DapE-ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="201"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ69912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="419" mass="47837" checksum="C6CBCDEE2E2A200A" modified="2013-03-06" version="1">MEKEIFNEIDNYRNEAIKNFIELLRIPAISPDYGGEGEIDKANKLLEILKEYFNFDTIEKYYSTDNRAKEKVRPNIIATYKGNEKKALWIITHIDVVPPGDLNAWKITKPFEPKIVDGKLYARGSEDNGQSLVASLYAVKSLMAKKIIPNITIKLAFVSDEEAGSEYGMKYLLKNHPEIFNKDDYYLIPDAGNSDGSLIEIAEKSILQFRLIIRGKQVHASTPHLGLNSHRISIQLSNQIDYILHERFKDLDELFDPPYSTFEPTMVKNSASSPNIIPGLHEITFDSRVIPKYKLDDVLNEVKNVIKNVEDKNKKIIEGIEYPQIELELIDKMQSPRPTNPNNKLVLEIKKAIKELRNVEAKIGGIGGITFASMLRSYDYDAVVWSTTDDVAHQPNEYSVLENLFNDAKVFALLMNRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9U4</accession>
    <name>L0A9U4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Spt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spt4</name>
        <name evidence="4" type="ordered locus">Calag_0420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of Spt4 and Spt5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal Spt4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0420"/>
    <dbReference type="EnsemblBacteria" id="AFZ70189">
        <property type="protein sequence ID" value="AFZ70189"/>
        <property type="gene ID" value="Calag_0420"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0420"/>
    <dbReference type="eggNOG" id="arCOG04077">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199467_0_0_2"/>
    <dbReference type="OMA" id="VDRCPYC"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00949">
        <property type="entry name" value="Spt4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007178">
        <property type="entry name" value="Spt4_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038589">
        <property type="entry name" value="Spt4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40704">
        <property type="entry name" value="PTHR40704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="SSF63393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Spt4" evidence="3">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="77" mass="8486" checksum="15112DD00F63811B" modified="2013-03-06" version="1">MPRKMPTKKIAMKACKNCGALVPKEANICPVCGSNNFTEDWEGIFVVISTDSEIAKELKFNKKGTYAIKVSGSYIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9U5</accession>
    <name>L0A9U5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-fuculose phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-fuculose-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fuculose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:12933"/>
            <dbReference type="ChEBI" id="CHEBI:18041"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57846"/>
            <dbReference type="EC" id="4.1.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.17" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232518.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0881"/>
    <dbReference type="EnsemblBacteria" id="AFZ70621">
        <property type="protein sequence ID" value="AFZ70621"/>
        <property type="gene ID" value="Calag_0881"/>
    </dbReference>
    <dbReference type="GeneID" id="14212141"/>
    <dbReference type="KEGG" id="clg:Calag_0881"/>
    <dbReference type="eggNOG" id="arCOG04226">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_3_1_2"/>
    <dbReference type="OMA" id="ICRYGRS"/>
    <dbReference type="OrthoDB" id="101802at2157"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008738">
        <property type="term" value="F:L-fuculose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="6">
        <location>
            <begin position="9"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="189" mass="21032" checksum="4BB397D8FFFC027C" modified="2013-03-06" version="1">MELNEFYLSQISDVMKLMYNRGIVQIRGGNASIIDRTRNIVYISPTGVPRHKISNNDVSVIDINGKAIVGFPSSEWRMHLSIYKEVKDAIAVVHAHPPYLLALNRSHKKLDLDYLTETSLRISCIDEVPLIKPGTQELADAVANSAKKGCNAIILDNHGVVAYSNETIYHALEIIEAIEDLAIIQLHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9W9</accession>
    <name>L0A9W9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70214">
        <property type="protein sequence ID" value="AFZ70214"/>
        <property type="gene ID" value="Calag_0446"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0446"/>
    <dbReference type="HOGENOM" id="CLU_2021386_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="122" mass="14369" checksum="77B1874CF338FCFD" modified="2013-03-06" version="1">MRKLLPYGLILHGVMLTVLINREETGGAWTSLKMSQWRLLPIIDFYKLNKETIEKLSDLFDRVSKKVLKEIPEQFNPENIDQIRFEIDCGFLNAFNQSPSEIENYLNKLYGKVYIALKRMWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9X2</accession>
    <name>L0A9X2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ilvD</name>
        <name evidence="16" type="ordered locus">Calag_0151</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231835.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0151"/>
    <dbReference type="EnsemblBacteria" id="AFZ69937">
        <property type="protein sequence ID" value="AFZ69937"/>
        <property type="gene ID" value="Calag_0151"/>
    </dbReference>
    <dbReference type="GeneID" id="14211411"/>
    <dbReference type="KEGG" id="clg:Calag_0151"/>
    <dbReference type="eggNOG" id="arCOG04045">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_2_2"/>
    <dbReference type="OMA" id="PFGRYVM"/>
    <dbReference type="OrthoDB" id="7176at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFZ69937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="559" mass="59984" checksum="D5EE9C1EEF923E15" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Z6</accession>
    <name>L0A9Z6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232142.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0478"/>
    <dbReference type="EnsemblBacteria" id="AFZ70244">
        <property type="protein sequence ID" value="AFZ70244"/>
        <property type="gene ID" value="Calag_0478"/>
    </dbReference>
    <dbReference type="GeneID" id="14211738"/>
    <dbReference type="KEGG" id="clg:Calag_0478"/>
    <dbReference type="eggNOG" id="arCOG00569">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118413_0_0_2"/>
    <dbReference type="OMA" id="LEYTICK"/>
    <dbReference type="OrthoDB" id="97519at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="188" mass="21692" checksum="B868E2FBA85C10E5" modified="2013-03-06" version="1">MNNCKPNKDFMRNIVNIVVSEYSGKISSNVVEDIKKRLGYAEAKYKFSIYGGNPLKIIDYLKSEDWNDLVSYVKSIHVEDLLKSILERLYNEYKNNCQEVSEFAKNLSESLNSNQEKKDNISFESIVNSLKLYGYQPEVMEKEVMFKDGNVSVRILLNDGSLSYTICKEGKAQNLDSIMQRTNKIKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA14</accession>
    <name>L0AA14_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major Facilitator Superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232593.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0973"/>
    <dbReference type="EnsemblBacteria" id="AFZ70696">
        <property type="protein sequence ID" value="AFZ70696"/>
        <property type="gene ID" value="Calag_0973"/>
    </dbReference>
    <dbReference type="GeneID" id="14212233"/>
    <dbReference type="KEGG" id="clg:Calag_0973"/>
    <dbReference type="eggNOG" id="arCOG00131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051127_0_0_2"/>
    <dbReference type="OMA" id="FNEISGW"/>
    <dbReference type="OrthoDB" id="34279at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="234"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="421" mass="46843" checksum="1AAB3C2287FA6D24" modified="2013-03-06" version="1">MGIKLYKDNWMYALIPYNIAMGPLSTLITLQILRLGGNVIDVAYTISLANLTSIIGSLIWGFAADYFDRKKQILLSLSTVGLTLVAISYTKSISLIEILYSILSFLNTASSTPLSLLIMSTVRKDLWASSYAKLNYLSSVGYLIGLLGSSLLAIYFKLDFIVILMGILVLISFGLSYYFIPKPELHIERTALLHNLESFLIRLKQIPTIFIHFPSKYSFKIFSLSRLKSLVSAYVPLLYIGMFLFYIASGIFNTEYPAGLKEGGLSNSLILIIFSIGMLFQIISYYLSPRFINKLGKARTSWISLLMRGSSYFIIGLLTVIIANKISLILSGIIFYPIAAGLAFSAFYTASSIMIFEIVKSGKEGSTLGVYSTLTGIAMTLGSFVSGYMVRYMGFGFTYIIAGIILLFNVYIFKTIERLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA19</accession>
    <name>L0AA19_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0504"/>
    <dbReference type="EnsemblBacteria" id="AFZ70269">
        <property type="protein sequence ID" value="AFZ70269"/>
        <property type="gene ID" value="Calag_0504"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0504"/>
    <dbReference type="eggNOG" id="arCOG00249">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010448_2_1_2"/>
    <dbReference type="OMA" id="GQGFYKK"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="7">
        <location>
            <begin position="10"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="6">
        <location>
            <begin position="201"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="6">
        <location>
            <begin position="319"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="673" mass="74286" checksum="1A32DA4B09575BBB" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA35</accession>
    <name>L0AA35_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase family protein associated with various cellular activities (AAA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232182.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0521"/>
    <dbReference type="REBASE" id="57678">
        <property type="entry name" value="Cla15908McrBP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70284">
        <property type="protein sequence ID" value="AFZ70284"/>
        <property type="gene ID" value="Calag_0521"/>
    </dbReference>
    <dbReference type="GeneID" id="14211781"/>
    <dbReference type="KEGG" id="clg:Calag_0521"/>
    <dbReference type="eggNOG" id="arCOG03779">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465911_0_0_2"/>
    <dbReference type="OMA" id="WLHESIR"/>
    <dbReference type="OrthoDB" id="64320at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="308"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="582" mass="68154" checksum="D0CA6FB87A91AEDE" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA37</accession>
    <name>L0AA37_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="3">P5C reductase</shortName>
            <shortName evidence="3">P5CR</shortName>
            <ecNumber evidence="3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">proC</name>
        <name evidence="6" type="ordered locus">Calag_1046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232665.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1046"/>
    <dbReference type="EnsemblBacteria" id="AFZ70768">
        <property type="protein sequence ID" value="AFZ70768"/>
        <property type="gene ID" value="Calag_1046"/>
    </dbReference>
    <dbReference type="GeneID" id="14212306"/>
    <dbReference type="KEGG" id="clg:Calag_1046"/>
    <dbReference type="eggNOG" id="arCOG00455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_1_2_2"/>
    <dbReference type="OMA" id="VVRVMTN"/>
    <dbReference type="OrthoDB" id="70966at2157"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="158"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="269" mass="29292" checksum="CBBBBA348474BC8A" modified="2013-03-06" version="1">MVRRSLSVIGAGVIGSAIIRSLISSGNDWKIIATAKSEESLNKIKKLGVEATRDNISAVKNSDIILLSIKPSQLIPLSDEINQFVKGKLIISVVAASPIKWLSKKFLGAKIVRAMPNINSETSSSFTVLSTNDNIDEDSKKLVEEIFSTIGYYEWIDEKYMNALTALSGSAPAFLAEIIDSLALGGIAAGLPRDLAYRAVLYTMKGTAKTLLEKGWSPHYLRDLVITPAGTTIRGIMVLQGNGLKRTIMEAVLEAQKKADEIENYLFNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA42</accession>
    <name>L0AA42_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1051"/>
    <dbReference type="EnsemblBacteria" id="AFZ70773">
        <property type="protein sequence ID" value="AFZ70773"/>
        <property type="gene ID" value="Calag_1051"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1051"/>
    <dbReference type="eggNOG" id="arCOG06965">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1431716_0_0_2"/>
    <dbReference type="OMA" id="HMIAPDH"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="193" mass="21693" checksum="F1CF6845B421151F" modified="2013-03-06" version="1">MNIMDLILIISIILIASIHMIAPDHWMPLTVLSIKRSYSLGNIVFISALIGFLHSFISIIISLLILYLGLSLLNFTDLKYFSLALIFIVCIYFLVGLFKERKESNTLENSSLMVSILPDPAIIPFIINSSILGMNFLIFSIILFISISSLALAFISVLVNRGIIKALSKLKPYYADYLIIIILIITAIYILFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA49</accession>
    <name>L0AA49_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="16">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="16">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="16">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">nnrD</name>
        <name evidence="15" type="synonym">nnrE</name>
        <name evidence="18" type="ordered locus">Calag_0220</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15 16">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14 16">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14 16">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="15 16">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="16"/>
    <dbReference type="EC" id="5.1.99.6" evidence="16"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0220"/>
    <dbReference type="EnsemblBacteria" id="AFZ70002">
        <property type="protein sequence ID" value="AFZ70002"/>
        <property type="gene ID" value="Calag_0220"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0220"/>
    <dbReference type="eggNOG" id="arCOG00018">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_4_1_2"/>
    <dbReference type="OMA" id="HNGGDAL"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="18" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 14 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="7 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="17">
        <location>
            <begin position="17"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="72"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="145"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AFZ70002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="521" mass="55469" checksum="EAB7E6B6E52BD27A" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA59</accession>
    <name>L0AA59_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps4</name>
        <name evidence="10" type="ordered locus">Calag_0549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232207.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0549"/>
    <dbReference type="EnsemblBacteria" id="AFZ70309">
        <property type="protein sequence ID" value="AFZ70309"/>
        <property type="gene ID" value="Calag_0549"/>
    </dbReference>
    <dbReference type="GeneID" id="14211809"/>
    <dbReference type="KEGG" id="clg:Calag_0549"/>
    <dbReference type="eggNOG" id="arCOG04239">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089738_1_1_2"/>
    <dbReference type="OMA" id="ARQFITH"/>
    <dbReference type="OrthoDB" id="93256at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_A">
        <property type="entry name" value="Ribosomal_S4_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_S4/S9_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022802">
        <property type="entry name" value="Ribosomal_S4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="5"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="103"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="180" mass="20586" checksum="EB7D812FEBF2DA3D" modified="2013-03-06" version="1">MGDPKNSRKRWEGPGHPWIKSRLETEIKIIGRYGLRNKKELWTAETIIRKVRHQARHLLALPEPQRSEASKSLLDRLFKLGLINKDSSLDDILGLTSENVLERRLQTIVFKKGMAKTIYQARQFITHGHIAINGKRVTNPGYLVTRDDEDKITYAVGSPIKEIMEKSIESVGTQEEKGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAC2</accession>
    <name>L0AAC2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0287"/>
    <dbReference type="EnsemblBacteria" id="AFZ70067">
        <property type="protein sequence ID" value="AFZ70067"/>
        <property type="gene ID" value="Calag_0287"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0287"/>
    <dbReference type="eggNOG" id="arCOG00147">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_745192_0_0_2"/>
    <dbReference type="OMA" id="CFTVVAF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="6"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="368" mass="40089" checksum="FCCE1E22AC14E0D7" modified="2013-03-06" version="1" precursor="true">MRDLKKSLFLTIGIIVMCFNSLYQYSWNALSPLLAKGLNASIDQIAFAFTLFTIFSTISQVIGGYIADIKGPKLIGIFSSILSSLGFLGIYLSKNLISFYLFWSLGSSGEGILYMIASNLAVKWYQEKRGFATGLVSFGFGLGATIANPFIISSKSFREPSLIIGLSELIVLPILLYFSEYPTKGISGLKPSIVITTRKWWLIYFSYIFSVVPLLSMSSALSFISREENIELLAVLISAFAFMSGVGRPIIGLISDKLGRYMTLMISIILVIIGSILLSINQIFISAIIIGLFDGALIPLYFSLIGDVFGAKYSTSNNGILYTGKAIAGLLGGIVFSLILIKGIFISGIYLFSSTLIGLVLLLLLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAC5</accession>
    <name>L0AAC5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytidylate kinase</fullName>
            <shortName evidence="5">CK</shortName>
            <ecNumber evidence="5">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytidine monophosphate kinase</fullName>
            <shortName evidence="5">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cmk</name>
        <name evidence="6" type="ordered locus">Calag_1099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytidylate kinase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232718.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1099"/>
    <dbReference type="EnsemblBacteria" id="AFZ70821">
        <property type="protein sequence ID" value="AFZ70821"/>
        <property type="gene ID" value="Calag_1099"/>
    </dbReference>
    <dbReference type="GeneID" id="14212359"/>
    <dbReference type="KEGG" id="clg:Calag_1099"/>
    <dbReference type="eggNOG" id="arCOG01037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079959_1_0_2"/>
    <dbReference type="OMA" id="FIFRDMA"/>
    <dbReference type="OrthoDB" id="110333at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00239">
        <property type="entry name" value="Cytidyl_kinase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011892">
        <property type="entry name" value="Cyt_kin_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02173">
        <property type="entry name" value="cyt_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="19"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="188" mass="21630" checksum="5D98FA0CCD8764AB" modified="2013-03-06" version="1">MEEEKKICDKIKPIIIVSGPPGSGKSTYAKRLSQDLGLRYYTSGQAFRELAKELNKDLIELNKIAQKDPEIDLKIDKKTLEEAKKGCIVIDSHLAAWILKDLPTISIYVKADLNSRVNRILSRDKVSLENSIEEATYREYTHWARFKEYYGIDIRDLSIFDLVIDTTKLSISDAYDIILNFVKKMLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAG8</accession>
    <name>L0AAG8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="5">3.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + succinate</text>
            <dbReference type="Rhea" id="RHEA:22608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:58087"/>
            <dbReference type="EC" id="3.5.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232322.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0675"/>
    <dbReference type="EnsemblBacteria" id="AFZ70424">
        <property type="protein sequence ID" value="AFZ70424"/>
        <property type="gene ID" value="Calag_0675"/>
    </dbReference>
    <dbReference type="GeneID" id="14211935"/>
    <dbReference type="KEGG" id="clg:Calag_0675"/>
    <dbReference type="eggNOG" id="arCOG01107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_2_2"/>
    <dbReference type="OMA" id="GTDAKQF"/>
    <dbReference type="OrthoDB" id="14646at2157"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010182">
        <property type="entry name" value="ArgE/DapE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01910">
        <property type="entry name" value="DapE-ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="8">
        <location>
            <begin position="173"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="411" mass="45108" checksum="2A244C0BE0BCA3E8" modified="2013-03-06" version="1">MNEDFVVKVTSDLIKINSQNPPGHTNEVVNYIKDLLSIHGIKYEIHEFEANKPNLIAKIGNGSPTLILNGHMDVVPPGDESKWIYPPFSGKIVDDKIFGRGATDMKGGLATILVSTLELSDLIEKNNGSLVFIASADEEVGGHAGMQGLVENNLIKGDAALIAEPSGYNRVSIGEKGLCQTKIVTRGLPSHGSMPILGDNAILKMYKAINLVKEGVEELNSKIVIPEDVSIAIKETANTYETIIKEKKLNLSVADIENQIKTISFNPGVIRGGTKINVVPDYCELELDMRIPPGCLCENVRNYIKNKLNNVAEIYPIDTSNANFTSLNEKIVKTALNSIEKILGKNADLHIETGATDGRYLRNIGIPTIIYGPGELFLAHAYNEYVKINDLKMALRITEDIIKEYLNLKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAH3</accession>
    <name>L0AAH3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232778.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1160"/>
    <dbReference type="EnsemblBacteria" id="AFZ70881">
        <property type="protein sequence ID" value="AFZ70881"/>
        <property type="gene ID" value="Calag_1160"/>
    </dbReference>
    <dbReference type="GeneID" id="14212420"/>
    <dbReference type="KEGG" id="clg:Calag_1160"/>
    <dbReference type="eggNOG" id="arCOG00908">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1357852_0_0_2"/>
    <dbReference type="OMA" id="IKALACY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019202">
        <property type="entry name" value="DUF2067"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09840">
        <property type="entry name" value="DUF2067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="201" mass="23528" checksum="0022DFE611F498B0" modified="2013-03-06" version="1">MKSLKKRFIFNLKEGYDIENIFKKINTVISSQEATIKVENNKLIIDFYVTPRDINYIKSKIKEILSFETNKNKVKGFKYSLKDLNPEGGKDFFDMLEFCLSKLGYKTTIQEEFLITTARKEKVYSLANIINENLKHISGKNYGNALIKALACYLTLRERDFEKINNVIEKGLSLGILEENKNKIYTRYSWKDTYEMLGKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAI4</accession>
    <name>L0AAI4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA replication protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232788.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1170"/>
    <dbReference type="EnsemblBacteria" id="AFZ70891">
        <property type="protein sequence ID" value="AFZ70891"/>
        <property type="gene ID" value="Calag_1170"/>
    </dbReference>
    <dbReference type="GeneID" id="14212430"/>
    <dbReference type="KEGG" id="clg:Calag_1170"/>
    <dbReference type="eggNOG" id="arCOG00417">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1412297_0_0_2"/>
    <dbReference type="OMA" id="YTERITC"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="192" mass="22300" checksum="9D765612AC13533E" modified="2013-03-06" version="1">MIFRKGGLHPFISNFIDNNLFLLVYGPSATGKTHLAFEIAKYLIDKKRDFSFIATEAQTFTYSKYFKYEIPIKLVITREQLIKEVIDDIKQNKFIIIDSINNLFRPFNDDVSQKELSLISSMMSLYGGFSTGQISQEDFETNKMSMDLWVIPWAKGIGITRKLKENTIELKLVRPKEIILGFKIIRDGIEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAJ2</accession>
    <name>L0AAJ2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="6">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gltX</name>
        <name evidence="10" type="ordered locus">Calag_0280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231958.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0280"/>
    <dbReference type="EnsemblBacteria" id="AFZ70060">
        <property type="protein sequence ID" value="AFZ70060"/>
        <property type="gene ID" value="Calag_0280"/>
    </dbReference>
    <dbReference type="GeneID" id="14211540"/>
    <dbReference type="KEGG" id="clg:Calag_0280"/>
    <dbReference type="eggNOG" id="arCOG04302">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_1_3_2"/>
    <dbReference type="OMA" id="MRFAPNP"/>
    <dbReference type="OrthoDB" id="8922at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="8">
        <location>
            <begin position="100"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="9">
        <location>
            <begin position="413"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="6">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="567" mass="65661" checksum="8725CA47D08EAE1B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAJ8</accession>
    <name>L0AAJ8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="8">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">argS</name>
        <name evidence="12" type="ordered locus">Calag_0709</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="8"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232352.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0709"/>
    <dbReference type="EnsemblBacteria" id="AFZ70454">
        <property type="protein sequence ID" value="AFZ70454"/>
        <property type="gene ID" value="Calag_0709"/>
    </dbReference>
    <dbReference type="GeneID" id="14211969"/>
    <dbReference type="KEGG" id="clg:Calag_0709"/>
    <dbReference type="eggNOG" id="arCOG00487">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_1_2"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="OrthoDB" id="7046at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="521"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="637" mass="72381" checksum="C5B3736129C8553B" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAL6</accession>
    <name>L0AAL6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232367.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0724"/>
    <dbReference type="EnsemblBacteria" id="AFZ70469">
        <property type="protein sequence ID" value="AFZ70469"/>
        <property type="gene ID" value="Calag_0724"/>
    </dbReference>
    <dbReference type="GeneID" id="14211984"/>
    <dbReference type="KEGG" id="clg:Calag_0724"/>
    <dbReference type="eggNOG" id="arCOG01356">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_4_3_2"/>
    <dbReference type="OMA" id="GNWPPAW"/>
    <dbReference type="OrthoDB" id="90547at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="192"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="477" mass="54725" checksum="366DD36B3A3ECCCE" modified="2013-03-06" version="1">MKVLLTLPPEIHNLEIYRVTGMKAPPLGLLSIAAVLERYGHKVEVIDSPTLQLDFNSWLSNIKAIKPDLIGISIQTPMAPKAYKAVKILKEEFPGIPIIAGGTHPSVMVEEALREGFDIVVRGEGEYTTLELVNYLENKGFEKSGLSDIAGIAFNNYGKVVKTKDRPLIQNLDELPWPARHLVDINKYTLFNKDINIAHIMASRGCPYGCIYCITSYYWGRRYRYRSAQNVVDEIKYLYEKYHTKTIVFTDDEFTANWKFVRDFIDLIKKNNLDISFSCGTRVDLINKDLMKLLYDNGCNALYFGVESGSQDTLNKIGKRITIEQAKKVFSWAKELKGFTTGSFILGFPWETIDDMKNTIDLAIKLDPNYAQFTALTPYPGTPLYDFAVNNNLIVDHNWEHYTTVRPVMRGFNFTTSDLGKMIVYAYRKFYVRFGFMAREAKAGRFFDLFKIITKNLIFSPVENKIKKVFEPLRWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAL7</accession>
    <name>L0AAL7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232040.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0366"/>
    <dbReference type="EnsemblBacteria" id="AFZ70142">
        <property type="protein sequence ID" value="AFZ70142"/>
        <property type="gene ID" value="Calag_0366"/>
    </dbReference>
    <dbReference type="GeneID" id="14211626"/>
    <dbReference type="KEGG" id="clg:Calag_0366"/>
    <dbReference type="HOGENOM" id="CLU_1727150_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="151" mass="16459" checksum="B8AFE8D750FBF9AF" modified="2013-03-06" version="1">MQNVNEKVPGKGLVIASIALAILFSLIVLYAGYSLSTLPASIFSNITKTYGQLSSLNLTGTDIIRLAANVLYGYGIIFLILGLVSIPFVYLPLYHNLPEKAIGPALAIGIIEIIVGIFSILFVIPGILMVIAWYQVRKFNYEMKIKASLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAM7</accession>
    <name>L0AAM7_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0735"/>
    <dbReference type="EnsemblBacteria" id="AFZ70479">
        <property type="protein sequence ID" value="AFZ70479"/>
        <property type="gene ID" value="Calag_0735"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0735"/>
    <dbReference type="eggNOG" id="arCOG02994">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116722_4_1_2"/>
    <dbReference type="OMA" id="DWEHEIF"/>
    <dbReference type="OrthoDB" id="105481at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="130" mass="15396" checksum="5DACFD5E703E5DC9" modified="2013-03-06" version="1">MKILNNIKPVIKKFYEIEEEKLPEDQAQKSYIRWLLTDDDGANNFFMRLFRMEPGGHINSHFHPWEHEIFIVEGKGRVRIGSKIYNVEEGNFLFIPPNAEHEYWADSELRFICIIPSKPTANEVDKPVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAN8</accession>
    <name>L0AAN8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232848.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1234"/>
    <dbReference type="EnsemblBacteria" id="AFZ70951">
        <property type="protein sequence ID" value="AFZ70951"/>
        <property type="gene ID" value="Calag_1234"/>
    </dbReference>
    <dbReference type="GeneID" id="14212494"/>
    <dbReference type="KEGG" id="clg:Calag_1234"/>
    <dbReference type="eggNOG" id="arCOG00374">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1202579_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="230" mass="24780" checksum="E0A57A966C29270C" modified="2013-03-06" version="1" precursor="true">MNNKKYYLAIFLFSLIFLSPIISHASQLSQINIDQYGNIMGYYIINVQNAPTVLTITIPGNITGYEAISLNNNSALPVSISNNNISVLVENNSLVNISFVSLSGAIQKGEVFILNLNLPVETNIVLPKNSVIIYTNASINDINSNIINVNPGNIEIEYSLQNVTSTLTTSTTTSTTFTSFTSTPTSTSSSTSTPSQTSPKPTKVSSTLYGIAAVVLIVIIILAVILLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAP3</accession>
    <name>L0AAP3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the archaeal NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232885.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1272"/>
    <dbReference type="EnsemblBacteria" id="AFZ70988">
        <property type="protein sequence ID" value="AFZ70988"/>
        <property type="gene ID" value="Calag_1272"/>
    </dbReference>
    <dbReference type="GeneID" id="14212532"/>
    <dbReference type="KEGG" id="clg:Calag_1272"/>
    <dbReference type="eggNOG" id="arCOG00972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108783_0_0_2"/>
    <dbReference type="OMA" id="RFQPFHY"/>
    <dbReference type="OrthoDB" id="90722at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00243">
        <property type="entry name" value="NMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006418">
        <property type="entry name" value="NMN_Atrans_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="183" mass="20756" checksum="3C62659427D33F35" modified="2013-03-06" version="1">MLLFIGCINLVERALIYGRFQPFHLGHLSLVKWSFEQGFDEVAILVGMASENYTPRNPFTAGERIEMARLSLKDSGIPLDKVITATIPTLEISIGCAYYVLSYIPKVKAILTRNPVISKAFADAGIEVITPPIFNRNEWRGQYIRELMAKNDSKWKNYVTPSVVSYIEEINGIERVRKINSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAP8</accession>
    <name>L0AAP8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0418"/>
    <dbReference type="EnsemblBacteria" id="AFZ70187">
        <property type="protein sequence ID" value="AFZ70187"/>
        <property type="gene ID" value="Calag_0418"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0418"/>
    <dbReference type="eggNOG" id="arCOG00031">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086256_0_0_2"/>
    <dbReference type="OMA" id="HVARNIG"/>
    <dbReference type="OrthoDB" id="106448at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="281" mass="32100" checksum="FC6FD2265FFF6721" modified="2013-03-06" version="1">MEILERVNTMSERHDSWHKQDEDGKNNFFDMLDSSKNVKLMVFRLLGALKYFYSFKELEERLNVPAQILWRYVTLRTVPERSTAEKILNKIRSSHIIDDILSKYYIENEELWSLLSNPGIMTLAGLRALDDLKDQKINVIVSAPDSYAAALGATFSSLFHAKLCAASHSPYSKHIISKNYKVSSEFFDVLLLPRECISRKSKIIIVTIDGNKTALLSSMIDLAITRQTHVEGIVAVMGSKSKIEELAKTKLKYNTKTIVLINTDDIKEIKHKEQSVKVDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAQ6</accession>
    <name>L0AAQ6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0429"/>
    <dbReference type="EnsemblBacteria" id="AFZ70197">
        <property type="protein sequence ID" value="AFZ70197"/>
        <property type="gene ID" value="Calag_0429"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0429"/>
    <dbReference type="eggNOG" id="arCOG04414">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2645680_0_0_2"/>
    <dbReference type="OMA" id="ELNDNCI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="76" mass="8467" checksum="B312B3963F92F41A" modified="2013-03-06" version="1">MMEVNFKICSNDKIDPLYKSLLAEVNQSSPKKGKVRVELNDNCINLFISSNTLSGLRAISNSYLNLIYAIINSLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAS9</accession>
    <name>L0AAS9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1277"/>
    <dbReference type="EnsemblBacteria" id="AFZ70991">
        <property type="protein sequence ID" value="AFZ70991"/>
        <property type="gene ID" value="Calag_1277"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1277"/>
    <dbReference type="eggNOG" id="arCOG03879">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156325_0_0_2"/>
    <dbReference type="OMA" id="EYWSDES"/>
    <dbReference type="OrthoDB" id="122997at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="125" mass="14397" checksum="7189D771ED7C4328" modified="2013-03-06" version="1">MINVSDGKSVEEVEEEKVISDNLSVIYEDTDLVVYTAPNEEELKDILLDLLRKNGKMSIKDFHRYLSGLASEDKIRYALNELLKDEAVIIDRQGYFYSMELLNNGEYSPEEVEELMDNQPDGEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAV8</accession>
    <name>L0AAV8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="1">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.25" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232053.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0381"/>
    <dbReference type="EnsemblBacteria" id="AFZ70155">
        <property type="protein sequence ID" value="AFZ70155"/>
        <property type="gene ID" value="Calag_0381"/>
    </dbReference>
    <dbReference type="GeneID" id="14211641"/>
    <dbReference type="KEGG" id="clg:Calag_0381"/>
    <dbReference type="eggNOG" id="arCOG01015">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_747264_0_0_2"/>
    <dbReference type="OMA" id="DGGLYIK"/>
    <dbReference type="OrthoDB" id="61936at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="PTHR21568"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="406" mass="46856" checksum="D7651FFFDD530764" modified="2013-03-06" version="1">MEDDSQINDEIINPAMNILKNFPLCDRCLGRQFAKLGIGYSNVDRGKSIKMVLLMHIHKKIKYENLEKEKINDLLINMGSISYNFYKNLFGNEPSYKKCYLCKDTLDKYIYDTAIEISNKMKNDKIKKFLIGVKVDEDIISKEEKLKSTFKLSYGESIKNELKREIGKRIQQLDPEHRADFNSPEVIYEVSFPNLEIREQIVSLLIYGRYKKFKRGISIIGPKSKNSVLNDISKAFNAGGVVVHVPERDESEFRTLGKGSSIILEVKGSKKEDININLIEGHSSIINIDKIERKRGQLNSLSNRNYIKIYRVLILCENKIKDEYIEKLNNINNINIQQKVNRKNLKGIGREIKCYRITSNVIECLISMDQNLYIKEFINGNKSNPSVSSILENNCDVIESDLLSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAW2</accession>
    <name>L0AAW2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycerol-1-phosphate dehydrogenase [NAD(P)+]</fullName>
            <shortName evidence="11">G1P dehydrogenase</shortName>
            <shortName evidence="11">G1PDH</shortName>
            <ecNumber evidence="11">1.1.1.261</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Enantiomeric glycerophosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">sn-glycerol-1-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">egsA</name>
        <name evidence="15" type="ordered locus">Calag_1344</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:21412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>NADP(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycerol-1-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.261" evidence="11"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232950.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1344"/>
    <dbReference type="EnsemblBacteria" id="AFZ71053">
        <property type="protein sequence ID" value="AFZ71053"/>
        <property type="gene ID" value="Calag_1344"/>
    </dbReference>
    <dbReference type="GeneID" id="14212604"/>
    <dbReference type="KEGG" id="clg:Calag_1344"/>
    <dbReference type="eggNOG" id="arCOG00982">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038362_0_0_2"/>
    <dbReference type="OMA" id="ALHGEQC"/>
    <dbReference type="OrthoDB" id="57545at2157"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106357">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106358">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase [NADP+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00497_A">
        <property type="entry name" value="G1P_dehydrogenase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023002">
        <property type="entry name" value="G1P_dehydrogenase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFZ71053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="351" mass="38199" checksum="424D98542B065EE6" modified="2013-03-06" version="1">MISKHSIDLPQRIIIGEDILDNIGEQVLQIFNKGKSVLILTGPNVYNKYFNKVKESLEDKGFSVSYKIAGSPTVDYALSLSEEVSKDRFDILLGLGGGRSIDLAKYIAMNLEKNFISVPTAASHDGITSPFVTLRGFDRFHSKPAKPPKLILIDVNVILSAPRRYNVAGFGDLIGKYTSVLDWRLAHKLKGEYYADYAASLALMSARHVSSYAKEIGVGSKDGIRVLLEALVSSGVAMCIAGSSRPASGSEHLFAHALEMISKNPPLHGEAVGVGTIMMSYLHGKDWKKIRNLLKTVGAPVNAKELGVSEEEIIQSLVKSVSIRPERYTILGETGLNEKAAEDLAKNTLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAZ6</accession>
    <name>L0AAZ6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl29</name>
        <name evidence="5" type="ordered locus">Calag_1374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1374"/>
    <dbReference type="EnsemblBacteria" id="AFZ71083">
        <property type="protein sequence ID" value="AFZ71083"/>
        <property type="gene ID" value="Calag_1374"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1374"/>
    <dbReference type="eggNOG" id="arCOG00785">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_2_0_2"/>
    <dbReference type="OMA" id="TIMREEE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="71" mass="8264" checksum="FFCBC30CF9F45A77" modified="2013-03-06" version="1">MGKYRLKMNDLKKMQEEEVKKTLNDINTELTVLRHKASTGSLDNPARIKQLKKNKARILTLLNEKKKANNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAZ9</accession>
    <name>L0AAZ9_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L7Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ribosomal protein L8e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpl7ae</name>
        <name evidence="10" type="ordered locus">Calag_0547</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit. Probably part of the RNase P complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232205.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0547"/>
    <dbReference type="EnsemblBacteria" id="AFZ70307">
        <property type="protein sequence ID" value="AFZ70307"/>
        <property type="gene ID" value="Calag_0547"/>
    </dbReference>
    <dbReference type="GeneID" id="14211807"/>
    <dbReference type="KEGG" id="clg:Calag_0547"/>
    <dbReference type="eggNOG" id="arCOG01751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_4_0_2"/>
    <dbReference type="OMA" id="KPFYVRF"/>
    <dbReference type="OrthoDB" id="114541at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00326">
        <property type="entry name" value="Ribosomal_L7Ae_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_L7Ae/L8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022481">
        <property type="entry name" value="Ribosomal_L7Ae_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_L7Ae_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000948">
        <property type="entry name" value="Ribosomal_L7Ae_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00884">
        <property type="entry name" value="RIBOSOMALHS6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03677">
        <property type="entry name" value="eL8_ribo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="9">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="127" mass="13570" checksum="B0ECB24C829049CE" modified="2013-03-06" version="1">MSKPSYVLFEVPEDLAEEVYKVVGKAKESGKVKKGTNETTKAVERGNAKLVVIATDVDPPEIVAHLPLLCDAKKIPFVYVPSKKKLGEAVNIEVGAASVAIVEGGEAENDIKKVVEKIKELRAKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB10</accession>
    <name>L0AB10_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar pyrophosphorylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232128.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0463"/>
    <dbReference type="EnsemblBacteria" id="AFZ70230">
        <property type="protein sequence ID" value="AFZ70230"/>
        <property type="gene ID" value="Calag_0463"/>
    </dbReference>
    <dbReference type="GeneID" id="14211723"/>
    <dbReference type="KEGG" id="clg:Calag_0463"/>
    <dbReference type="eggNOG" id="arCOG00663">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_2_2_2"/>
    <dbReference type="OMA" id="TMCVREY"/>
    <dbReference type="OrthoDB" id="78828at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="236" mass="26545" checksum="FE463EB2367F0E10" modified="2013-03-06" version="1">MSLALILAGGYGKRLRPLTLDKPKPLVPINERPLIVYQLEWLKHYDIDEIALLAGYHKEKLIEELGSGSKYGVSISYVIEDEPLGTGGALKKAAHIYKNHEKFLVTNGDIITNIDPNIILSSLKGNIIAAMAVVPLRSPYGVLDIDNNGYVKGFKEKPLLYDYWINAGIYAFKPEIINYLPDKGDIETTTFPKLSSEGKMIAIKFEIPKYYWRSIDTHKDLEEASDEINRMGGLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB45</accession>
    <name>L0AB45_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="4">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dtdA</name>
        <name evidence="5" type="ordered locus">Calag_0506</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DtdA deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232168.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0506"/>
    <dbReference type="EnsemblBacteria" id="AFZ70270">
        <property type="protein sequence ID" value="AFZ70270"/>
        <property type="gene ID" value="Calag_0506"/>
    </dbReference>
    <dbReference type="GeneID" id="14211766"/>
    <dbReference type="KEGG" id="clg:Calag_0506"/>
    <dbReference type="eggNOG" id="arCOG01616">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056464_1_0_2"/>
    <dbReference type="OMA" id="CYEATHH"/>
    <dbReference type="OrthoDB" id="84039at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00562">
        <property type="entry name" value="Deacylase_DtdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018033">
        <property type="entry name" value="Deacylase_DtdA_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007508">
        <property type="entry name" value="DtdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34667">
        <property type="entry name" value="PTHR34667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04414">
        <property type="entry name" value="tRNA_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016210">
        <property type="entry name" value="UCP016210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="273" mass="31166" checksum="49162267B06C6D20" modified="2013-03-06" version="1">MVKYAISYSINDMVGKNVINNLLEKLGKININYCEKAVSCYDVNKAKIAGFNEETINFDFLDNVFHEEDFIIVVSKHQSTSNNKTLSIHHTGNPSNEANFGGKPRELSYVNPIITKFIFKNYYKNSRKLSDYSFTFEATHHGPTSLRKPLLFIEIGSTEKEWNDINAVDALSQTLVDVLESDPKENCIPAIGIGSTHYPKKFTDLELNNDYCFGHIFSKYYVDYLDKDLLEQSIKKSIPIARVAIIEKKGIKSETRKKIENILESLNVEVIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB48</accession>
    <name>L0AB48_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IMP dehydrogenase/GMP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232173.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0511"/>
    <dbReference type="EnsemblBacteria" id="AFZ70275">
        <property type="protein sequence ID" value="AFZ70275"/>
        <property type="gene ID" value="Calag_0511"/>
    </dbReference>
    <dbReference type="GeneID" id="14211771"/>
    <dbReference type="KEGG" id="clg:Calag_0511"/>
    <dbReference type="eggNOG" id="arCOG00612">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_1_1_2"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="OrthoDB" id="58700at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="5">
        <location>
            <begin position="7"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="191"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="421" mass="45104" checksum="37A88FFFDB083E44" modified="2013-03-06" version="1">MSIEEFITFNDVVIVPGRSPIEPSKVNISGKITKNITLTIPVVSSPMDTVTDWKMATTLARLGAIGIIHRNMSKEEQALQVSKVKDQKPYLWEEVQKVDPDSKIEDVLSKEQDNFAVVINKEIKAIILKIGADYSLHSKKIDYLSKLLSMINLTPTLDENNKLRVGAGISPFDLERAKILDKAGADVLVVDVAHLHNDNALSSLAKIAKNVSAEIVAGNLGTIDGVKDTISKVENVSGLRMGISSGSICLTGEVAGASVPTLTATINARKALEELGLFGKIPIIADGGIKNAGDAAKAIIAGANSIMVGRYLACTEESPGIKIRIGDKVYKQYRGMASRGAMEKRYAEDRYSKPSKAIEEGVEGLVEYCGSAINAISEMALGLQASLGYAGARNIEEAWNGRLAKITSMGAKEVGIHDIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB49</accession>
    <name>L0AB49_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Raf kinase inhibitor-like protein, YbhB/YbcL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232536.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0900"/>
    <dbReference type="EnsemblBacteria" id="AFZ70639">
        <property type="protein sequence ID" value="AFZ70639"/>
        <property type="gene ID" value="Calag_0900"/>
    </dbReference>
    <dbReference type="GeneID" id="14212160"/>
    <dbReference type="KEGG" id="clg:Calag_0900"/>
    <dbReference type="eggNOG" id="arCOG04702">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083918_3_2_2"/>
    <dbReference type="OMA" id="CWVVVNI"/>
    <dbReference type="OrthoDB" id="98388at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="167" mass="18885" checksum="C5377085252E86C5" modified="2013-03-06" version="1">MGESLAKEYLFKEGKEFSLISDSFKNGEVIPKRHTCEGDNISPKLSWKFDEAKSYTLIVYDPDAPMKTFIHWVIYDIPSSINSLYEAIPKNENVDVGKQGRNDFGEIGYDGPCPPRGHGFHRYYFALHGLNVESLDIRGEANANKVLNSMKGKVIGYAVLMGKYQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB68</accession>
    <name>L0AB68_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator containing CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0534"/>
    <dbReference type="EnsemblBacteria" id="AFZ70295">
        <property type="protein sequence ID" value="AFZ70295"/>
        <property type="gene ID" value="Calag_0534"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0534"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_1_2"/>
    <dbReference type="OMA" id="MTRANCG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="81"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="147" mass="16335" checksum="12F78DA6EF637B1C" modified="2013-03-06" version="1">MIYMQNEGPPIITICPGLQPKVYPKDNVSKAIQVMNETGIGAVAVIDEHGKIIGIFTERDLLNKVLVKNKKLEEVIIEDVMTKNPIIGNPSWSASKAIKTMAYYGFRHLPIVDDAGYYLCMVTIRELEKFITQIDIGVEPSEILGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB70</accession>
    <name>L0AB70_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC-type transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_0637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0637"/>
    <dbReference type="EnsemblBacteria" id="AFZ70392">
        <property type="protein sequence ID" value="AFZ70392"/>
        <property type="gene ID" value="Calag_0637"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0637"/>
    <dbReference type="eggNOG" id="arCOG01270">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_2_0_2"/>
    <dbReference type="OMA" id="YIVGCFM"/>
    <dbReference type="OrthoDB" id="66651at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="296" mass="32085" checksum="B0C0C59EE5FF630C" modified="2013-03-06" version="1" precursor="true">MAVPSLLPYTIAIGLLLGIYYAFMALGLNLVFGVVRMINLSHGDIVMLGSYMAYYFLIYYSIKVGLSFVIAFPIFFLLGILIYFAFVPKLESSNDPEMNSFTAFFGLSLAIEAISFLIFGNYYHALPNSALLGGSFTLFGFRTPKIYLAISALSVIILAITYLYLNKTMLGKATKALMQNKEQAISFGINPRWVTLITFAYGFGVAGMAGAIGPYILGTIYPSMGDFITILAFTIVIIGALGNPLSTIIGGLVFGVFYELLQVYISGLSLAITFFALLAIVVIRPGGILGGVQREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB75</accession>
    <name>L0AB75_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative nucleic acid-binding protein with PIN domain and Zn ribbon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233008.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1403"/>
    <dbReference type="EnsemblBacteria" id="AFZ71111">
        <property type="protein sequence ID" value="AFZ71111"/>
        <property type="gene ID" value="Calag_1403"/>
    </dbReference>
    <dbReference type="GeneID" id="14212663"/>
    <dbReference type="KEGG" id="clg:Calag_1403"/>
    <dbReference type="eggNOG" id="arCOG00721">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109674_2_0_2"/>
    <dbReference type="OMA" id="RERSSHN"/>
    <dbReference type="OrthoDB" id="102178at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="PTHR12814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="4">
        <location>
            <begin position="14"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="143" mass="16129" checksum="E7A86DC13243A0E5" modified="2013-03-06" version="1">MKGFSQDYYPIGEKCLVLDAGAIFSGFILSSLDRCITTPSVINEVKDEQSKNSVNMVSSANKLIIIEPEKTFINKVKDEATKNNVYKKLSNTDIDVLALSIQLKEFCKEVYLVTDDYSIQKLALKLGIKIVKIKYKGIKELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB80</accession>
    <name>L0AB80_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type spermidine/putrescine transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233045.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1442"/>
    <dbReference type="EnsemblBacteria" id="AFZ71148">
        <property type="protein sequence ID" value="AFZ71148"/>
        <property type="gene ID" value="Calag_1442"/>
    </dbReference>
    <dbReference type="GeneID" id="14212702"/>
    <dbReference type="KEGG" id="clg:Calag_1442"/>
    <dbReference type="eggNOG" id="arCOG00175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OMA" id="HFIILGP"/>
    <dbReference type="OrthoDB" id="88924at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="343" mass="39631" checksum="2F5F0B17DE149046" modified="2013-03-06" version="1">MKALSIRNLVTKVNTFTLGPINLDVDANEYYIISGPNGSGKTTLLKTILGFYRPLSGKIMLYDKDITYMPIEKRRIGYVTQNYSLFNNMDVKANIEYGLKMLKLNKQERERKVKEIASTLKIENLLNKKPKELSMGQQQLVSIARALVIEPKVLLLDEPLSNLDPNVKRNLREILRIIVRSKTTTIIHISHFIEDAFELSTKMGFMYKGKIIEEGDPIEMINNPKTKEFSEYLGYSNIILLNNVDSEIKNILNEIDFRNDFIKDNYLVFRPEDAIICKNKCCKNSLEGEIEEINITERGFNYKVKTKSHDFVIFSKDIFKENDIVNICIDAKRLKIVKSVEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB82</accession>
    <name>L0AB82_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps11</name>
        <name evidence="6" type="ordered locus">Calag_0550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located on the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232208.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0550"/>
    <dbReference type="EnsemblBacteria" id="AFZ70310">
        <property type="protein sequence ID" value="AFZ70310"/>
        <property type="gene ID" value="Calag_0550"/>
    </dbReference>
    <dbReference type="GeneID" id="14211810"/>
    <dbReference type="KEGG" id="clg:Calag_0550"/>
    <dbReference type="eggNOG" id="arCOG04240">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_6_0_2"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="OrthoDB" id="114285at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019961">
        <property type="entry name" value="Ribosomal_S11_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03628">
        <property type="entry name" value="arch_S11P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="131" mass="14091" checksum="2276833566A8E248" modified="2013-03-06" version="1">MAFRELRWGIAHIYSSFNNTIIHITDLTGSETSSRVSGGMVVKADREKPQPYAAMIAAIRAAQTSMDRGITAIHIKVRAPGGHGPKTPGPGAQSAIRALARAGFVIGRIEDVTPIPHDTTRRPGGRRGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABC2</accession>
    <name>L0ABC2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232616.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0996"/>
    <dbReference type="EnsemblBacteria" id="AFZ70719">
        <property type="protein sequence ID" value="AFZ70719"/>
        <property type="gene ID" value="Calag_0996"/>
    </dbReference>
    <dbReference type="GeneID" id="14212256"/>
    <dbReference type="KEGG" id="clg:Calag_0996"/>
    <dbReference type="eggNOG" id="arCOG11610">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1340681_0_0_2"/>
    <dbReference type="OMA" id="VATMRII"/>
    <dbReference type="OrthoDB" id="141061at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="204" mass="21817" checksum="43AA1CD4EB49BDE6" modified="2013-03-06" version="1" precursor="true">MFWFKKLLPRIIFGIAIALIIASVFATQYGVKTYSSWSIGYDGKSAPSILAAIVPTSSGVAQINITGVSQALYMNLTGNPLTLLGEAGGLGLKTVNTISHDDFQTGVYFVVTGLQGNPITAEQAFQGLVKNAQKVGNSYIVKKTVNPEESIVVLAFPNSSTVLINENFKVTGYGHISLSLGIELGILLILISIVLEIILRRSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABC7</accession>
    <name>L0ABC7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1001"/>
    <dbReference type="EnsemblBacteria" id="AFZ70724">
        <property type="protein sequence ID" value="AFZ70724"/>
        <property type="gene ID" value="Calag_1001"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1001"/>
    <dbReference type="eggNOG" id="arCOG04321">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064235_0_0_2"/>
    <dbReference type="OMA" id="SISPWME"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007841">
        <property type="entry name" value="UPF0210"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37560">
        <property type="entry name" value="PTHR37560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05167">
        <property type="entry name" value="DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="366" mass="40061" checksum="B1499C11A0423FD2" modified="2013-03-06" version="1">MYEIRTLTIHYGKSLSDDMEDAKDEIETFLSRFSEEVDNYKSQFGISPTYLRIAFPNPPFLDDLESFVKLLEDLTERYSINLGQLDSNYNSLSEAILLIASNKMFASILMKGNDWDEAIKISKALHELTSNSPELGANIGVNTLNEKHFITPYYPLASAIPGKIMISAALTYPNYLKDSYTKNGYDGMISSIINAGKIAEDMAMHVANALNIEYAGVDLSVSPWMEESSLGLVEQVSGVRLPKPGFAYGLKRVNDALLISSKSLKTTGFNEVMLPIAEDSKLKARASEGEFNARDLVKLSGVCLAGLDLAVVPHNIVDVAGLLLDESAYAKMKSKALGVRIIPVEGVEPGDKVDLGRFGETPVISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABD3</accession>
    <name>L0ABD3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_1462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233063.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1462"/>
    <dbReference type="EnsemblBacteria" id="AFZ71166">
        <property type="protein sequence ID" value="AFZ71166"/>
        <property type="gene ID" value="Calag_1462"/>
    </dbReference>
    <dbReference type="GeneID" id="14212722"/>
    <dbReference type="KEGG" id="clg:Calag_1462"/>
    <dbReference type="eggNOG" id="arCOG00980">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073526_1_0_2"/>
    <dbReference type="OMA" id="IREFHRH"/>
    <dbReference type="OrthoDB" id="116879at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ71166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="260" mass="29691" checksum="C921C3C07FAF0B43" modified="2013-03-06" version="1">MVFNDGDFVLINYTIKVKNGDNYLVQETTYEDVAKQSNIYDANKKYGPYLIVIGKSTLIAAVNEAIKEMQPGEKKEIKADPSKAYGERREELVIRVPIKQLKRYNIPLRIGQQVEIGGRIGIIERIAERFAYIDFNHPLAGKELLIDLEVVKKIEDFNEKVRYLVERWLGIPGNDIEVSGNQNIINIGLPVKAIYINDLDSKLQLLVGDLYQYIKPEEVNLNIKVNTKEIQSEEKAKEGQEAKEQEAKPQEEKVAEENAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABD5</accession>
    <name>L0ABD5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps7</name>
        <name evidence="9" type="ordered locus">Calag_1507</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5 7">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1507"/>
    <dbReference type="EnsemblBacteria" id="AFZ71208">
        <property type="protein sequence ID" value="AFZ71208"/>
        <property type="gene ID" value="Calag_1507"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1507"/>
    <dbReference type="eggNOG" id="arCOG04254">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063975_0_0_2"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_A">
        <property type="entry name" value="Ribosomal_S7_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_S5/S7_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026018">
        <property type="entry name" value="Ribosomal_S7_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="8">
        <location>
            <begin position="63"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ71208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="204" mass="23392" checksum="088642157254979F" modified="2013-03-06" version="1">MSSQTQLPDIDKVGSGLNEIKLFDKWSWEGIEIRDPSLKKYISLKPTYLPHSGGRHEHKRFGKAEVNVVERLINRLMYPGKNGGKKMMAYNIVRNAFDIIYLETKENPIQVFVRAIENSAPREETTRIMYGGIVYRVSVDVSSQRRVDLAIRFITEGARECSFGNIKPIEQCLADEILLASRNDPQSYSIKQKEEIERIALSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABE2</accession>
    <name>L0ABE2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent glutamate synthase beta chain-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1017"/>
    <dbReference type="EnsemblBacteria" id="AFZ70739">
        <property type="protein sequence ID" value="AFZ70739"/>
        <property type="gene ID" value="Calag_1017"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1017"/>
    <dbReference type="eggNOG" id="arCOG01292">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_3_2"/>
    <dbReference type="OMA" id="DRANMPG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="358" mass="39238" checksum="A48930C00A2AB87D" modified="2013-03-06" version="1">MILEVKFLRCKPDQVPTGVGKKVAIIGAGTAGLGAAGLLRCKGYQVTVYDMLPEPGGMLIFGIHVYRIPKPPVREGVKELMDAGVEFVLNTKINANVSYGIMDKIISPKQSVDLEDIIKEHDATLIATGTWESNKMKVKGEDLPWVFPSMEFIVATHLAKFGYRPWDIVPNLSGRLLVIGGGYTAEDAAYIPMTYDEFKNKMKKVVLSYRRSKKEAPMGVMEMNNLEAAGIEIWELTVPTEFREENGKRIVKIIRNQLVHAPGEKRPKPVPIPGSEFETEFDFASKAVGERPTAPLTNNCCGITLTDWGTIVTDKNLMTTRKGVFAAGDVVHGPSQLGPALKSGMDAANAIIKYLSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABG3</accession>
    <name>L0ABG3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type branched-chain amino acid transport systems, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232288.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0635"/>
    <dbReference type="EnsemblBacteria" id="AFZ70390">
        <property type="protein sequence ID" value="AFZ70390"/>
        <property type="gene ID" value="Calag_0635"/>
    </dbReference>
    <dbReference type="GeneID" id="14211895"/>
    <dbReference type="KEGG" id="clg:Calag_0635"/>
    <dbReference type="eggNOG" id="arCOG00924">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="EKVYNYF"/>
    <dbReference type="OrthoDB" id="55756at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="232" mass="25667" checksum="8B3D9A784C3819E3" modified="2013-03-06" version="1">MLKVDHIYSGYGDLKIIKDVTFDVNKDETVLILGLNGAGKTTLLKSIAGFVKLFSGKIILDNNDITKLDSYKRAKLGITMIMEQAIFPDLTVKENMEIAHSKTRNSKFNDELNNILKTFPELKTFLKIKAQALSGGQRKMLSMAMALLSKPKLLILDEPSAGLSPLMVSRVVKYVSLLKENGITILIAEQNPSFIDVADKVMVLESGVIKLMGNASEIANNNEVRKTFFQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABH3</accession>
    <name>L0ABH3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Replication factor C large subunit</fullName>
            <shortName evidence="4">RFC large subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Clamp loader large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfcL</name>
        <name evidence="7" type="ordered locus">Calag_0648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the activator 1 small subunits family. RfcL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0648"/>
    <dbReference type="EnsemblBacteria" id="AFZ70400">
        <property type="protein sequence ID" value="AFZ70400"/>
        <property type="gene ID" value="Calag_0648"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0648"/>
    <dbReference type="eggNOG" id="arCOG00470">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027255_1_1_2"/>
    <dbReference type="OMA" id="GGWTRYG"/>
    <dbReference type="OrthoDB" id="24257at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01508">
        <property type="entry name" value="RfcL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023935">
        <property type="entry name" value="Rep_factor-C_lsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="47"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="416"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="473" mass="54661" checksum="BFFCB3D5A4498042" modified="2013-03-06" version="1">MILSNEVKIPWIIKYRPKRVDDIINQEEAKSQMLTWIHSWLEGKRPEKKALLLYGPPGVGKTSLVEAIANEYDLELLELNASDYRRTQDIKKTVANASQKRPLFKKMILILMDEIDGLSPRGDIGGVDELIKIIPNTMNPIILTANDPWKDNLRPIREYVSMVEFKPLTLNQVISVLQGICNKENLECEREALKFIAEKSMGDLRGAINDLEAVAEGYGKVTFNLVSVIVKGRDKSVDLWRTLNGVFYAKEAWQSRRSVMNSEEDYETLIAWFNDNVPLKYGDYEDLFRAMDSLSRASLFLKRAKSGDWDMLSYVFDLIGPGITYARKNGEILKNRFSYPQKIKIMGQMKSLRETRDRIAKILSERTLSSQRVIKSDVIQYLITIFRNGNIERVAMIARAYGFSEDDLKYLAGNRYKDIEKEMDRLREGKKEEINAKEKEVKKQTSLEFFGVKSSQVKKTEKGKRKYYKKDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABH7</accession>
    <name>L0ABH7_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Calag_0743</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232384.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0743"/>
    <dbReference type="EnsemblBacteria" id="AFZ70487">
        <property type="protein sequence ID" value="AFZ70487"/>
        <property type="gene ID" value="Calag_0743"/>
    </dbReference>
    <dbReference type="GeneID" id="14212003"/>
    <dbReference type="KEGG" id="clg:Calag_0743"/>
    <dbReference type="eggNOG" id="arCOG01180">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_3_3_2"/>
    <dbReference type="OMA" id="EIRCAKV"/>
    <dbReference type="OrthoDB" id="44076at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO" evidence="11">
        <location>
            <begin position="17"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFZ70487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="260" mass="30695" checksum="1EF743876D7CC23F" modified="2013-03-06" version="1">MKRYFDEKGKVEKRIKDEDIVKTVDEVLDSFTNYHIDKLINKRIIKEIKGSFSSGKESKLYWGKSYNNEEIAIKIFLTSAAEFRKSIKEYISGDPRFQSIPNKFRSLIYLWAKKEYTNLDKLKKNGINVPQPLGLSGNVLVMEFIGENGYRAPLINEIYKELEDEEIEKIYHDTKENIMKMVCNAKIVHADLSEYNIMYWKSKPYIIDVSQSVDINHPNAMSYLKRDLKNVYSFFSKLIEIEEYEEYEKGILKCLEEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-12-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABL1</accession>
    <name>L0ABL1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein TerC, possibly involved in tellurium resistance</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1553"/>
    <dbReference type="EnsemblBacteria" id="AFZ71251">
        <property type="protein sequence ID" value="AFZ71251"/>
        <property type="gene ID" value="Calag_1553"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1553"/>
    <dbReference type="eggNOG" id="arCOG09430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045644_1_2_2"/>
    <dbReference type="OMA" id="ADHAREY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="304" mass="34978" checksum="E318A31DCA770ACC" modified="2013-03-06" version="1">MITLILFGISIEFLFKKNFKYIILIWIALSLVYFMVLFIRTDFYESYLFLTSYLLEISLSLDNILVFLLIFTQFSISFEHQEKLVAIGSYSAIVLRFLFVYAGIELLNVFELGTIILSLLVLFSAFELAREEFNNEKEKEESNIIKFFKKYLKTDFSNNEFSFFVKKNGKIVPTKYLLVIFVIEISDIIFAFDSIPAIILITKNELIAYSSTIFGTLIIRSLYFNVNRSLSSIKHIEGFLAIGLGYIGISSLINSINKFIKTVYIPEYISVIVVVLIIAFGLLYSFLNNRMRTSKQTPSQGPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABM7</accession>
    <name>L0ABM7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232348.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0705"/>
    <dbReference type="EnsemblBacteria" id="AFZ70450">
        <property type="protein sequence ID" value="AFZ70450"/>
        <property type="gene ID" value="Calag_0705"/>
    </dbReference>
    <dbReference type="GeneID" id="14211965"/>
    <dbReference type="KEGG" id="clg:Calag_0705"/>
    <dbReference type="eggNOG" id="arCOG01434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_0_2"/>
    <dbReference type="OMA" id="LTAYEVW"/>
    <dbReference type="OrthoDB" id="16594at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="1">
        <location>
            <begin position="66"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="377" mass="43506" checksum="C7787D4982BE36BA" modified="2013-03-06" version="1">METDKNYKFKCIKCGFESYEEVLKCPRCGGPIQIVYDNLEWVIDSKIPSMWRYKSLLPKSDKIISFNEGLTPIRKIFGVLCKLETNNPTGLYADRASSIIVSSFKNKIIETRYEEDFTLSLAYYSKKAGIKLKVNVIPDNVDPQDLIIIAKLGSDISFINEMEKMELEYENPYTIEGLKTISYEIYEKNPKVEKIYVPAQSGTLVYALSKGFYEIKQIKKDFNEYELIAVKLRHSNIPEILNYSKYKIKISEVSSKEALESMIHLSKKGFNLKPLASSAYALAKIEGNGISIITGNRKISMHESKKYSELKKDIMNIFSDNKKRTAYEIWLELNKYSLKGIYKSLNMMVNNGELCEEPILRGERKIKVYWKCEDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABV6</accession>
    <name>L0ABV6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0851"/>
    <dbReference type="EnsemblBacteria" id="AFZ70592">
        <property type="protein sequence ID" value="AFZ70592"/>
        <property type="gene ID" value="Calag_0851"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0851"/>
    <dbReference type="eggNOG" id="arCOG00132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025894_2_0_2"/>
    <dbReference type="OMA" id="EESMIAH"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="392" mass="44233" checksum="57A32732EFCA56D8" modified="2013-03-06" version="1">MVYMNSGFARILISKSLRVFLSGIIAIITPIYLKYLGLTPFLIGISIFIIVLGNVVTNLILTWFRNKINIKTYLMIISLLFSIAGFMIFFSTQLYIIFIALFLGNISTSGTETGPFQSIETGILPELVNKNFINRAYGIYNFLGYALSSLGSLTSSIPSYLGESLFSFKIFYLIYGIGGLVMLINYSMLNFKEEPSLRIPIKKFDKNAKKDLYLITTLFSLDALGGGFILQSIIAYWFNLRYNVSLKILGPLFMAVNIITAMSILLAPLIAEKLGNLRTMVITHLISNFFLIMIPVFPSFWLSVLFLLLRQSTSQMDVPTRQAFIVEIFKKEYRVSFNAISNTFRSLASLAGSPIDGIALGYSLFTFPLFSGGFIKIIYDLAIFYYYHNRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABW9</accession>
    <name>L0ABW9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane-associated Zn-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Calag_1210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232826.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1210"/>
    <dbReference type="EnsemblBacteria" id="AFZ70929">
        <property type="protein sequence ID" value="AFZ70929"/>
        <property type="gene ID" value="Calag_1210"/>
    </dbReference>
    <dbReference type="GeneID" id="14212470"/>
    <dbReference type="KEGG" id="clg:Calag_1210"/>
    <dbReference type="eggNOG" id="arCOG00609">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028221_0_0_2"/>
    <dbReference type="OMA" id="AGWVGIL"/>
    <dbReference type="OrthoDB" id="89203at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044838">
        <property type="entry name" value="EGY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412">
        <property type="entry name" value="PTHR31412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="6">
        <location>
            <begin position="223"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="352" mass="39244" checksum="003A098B61E61171" modified="2013-03-06" version="1">METLEKNDIEKLILKYFDAKFVSQDKNALKYKIVGINESDLSKSFINLYKESFKLNYAVSLRKENNMLFIYVFKKVNRTNKFVVIILAIVTLISVYISGLVFNNQGKSLVYNPFAYLVALIVPLLLHETGHWLTMRRFKVPASPPYLLPAPPLQLGFLGTFGAVINMEWLPPTNNILALTGVMGPLTGFLSAIPFTVIGLKYSTLVPQSLVPPGSTINLVPLIVSIITYIEKIPTEYVIQPSAMMFASYIVFFVTFLNLIPVAQLDGGHVLRAALGERNHRIISIIFIFALIFAGLWYDTFAVFGLFAFFFFILSGGRHPGSAMGDDKLSKSGMIAVIIYSILLILTLPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABX1</accession>
    <name>L0ABX1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">K+-transporting ATPase, A chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Calag_0872</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232509.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0872"/>
    <dbReference type="EnsemblBacteria" id="AFZ70612">
        <property type="protein sequence ID" value="AFZ70612"/>
        <property type="gene ID" value="Calag_0872"/>
    </dbReference>
    <dbReference type="GeneID" id="14212132"/>
    <dbReference type="KEGG" id="clg:Calag_0872"/>
    <dbReference type="eggNOG" id="arCOG04804">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018614_3_0_2"/>
    <dbReference type="OMA" id="RQGWAIL"/>
    <dbReference type="OrthoDB" id="12407at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFZ70612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="535" mass="59571" checksum="A761E0AEE5B00D1F" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABX9</accession>
    <name>L0ABX9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PKD domain protein,extracellular solute-binding protein, family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232452.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0814"/>
    <dbReference type="EnsemblBacteria" id="AFZ70555">
        <property type="protein sequence ID" value="AFZ70555"/>
        <property type="gene ID" value="Calag_0814"/>
    </dbReference>
    <dbReference type="GeneID" id="14212074"/>
    <dbReference type="KEGG" id="clg:Calag_0814"/>
    <dbReference type="eggNOG" id="arCOG01533">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319962_0_0_2"/>
    <dbReference type="OrthoDB" id="6658at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="178"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="904" mass="100406" checksum="F9BB6341934B62C1" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABY6</accession>
    <name>L0ABY6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232524.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0887"/>
    <dbReference type="EnsemblBacteria" id="AFZ70627">
        <property type="protein sequence ID" value="AFZ70627"/>
        <property type="gene ID" value="Calag_0887"/>
    </dbReference>
    <dbReference type="GeneID" id="14212147"/>
    <dbReference type="KEGG" id="clg:Calag_0887"/>
    <dbReference type="eggNOG" id="arCOG00014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_2_2"/>
    <dbReference type="OMA" id="ECALIVL"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="303" mass="34122" checksum="6376972260EF6B23" modified="2013-03-06" version="1">MENKKQLHVSIGNINIDFISFINKKIKIDSSIESKDVWIGLGGAATNYAIAVSRLNHASKLIARTGKEIIKLGFLDKLKEEGVDISDIKITKEKPGVVMIIVNRRNSTRTMISSINANKRLDLKDIKIVGDHIHFSSINPRLLKYCNDIRKINGKDVTISYDPGGEACYNKEIINNLHLIDWLLINEKEFSCLNLKNKLNELFDNRLKFVVIKKGSLGAEILEKNKKISAKINLNIKQLDPTGAGDAFDASYNVFFKETNDEELALKFAIASGSSKVEKIGSSNMPYLYEINPKIKFVETFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC48</accession>
    <name>L0AC48_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232497.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0860"/>
    <dbReference type="EnsemblBacteria" id="AFZ70600">
        <property type="protein sequence ID" value="AFZ70600"/>
        <property type="gene ID" value="Calag_0860"/>
    </dbReference>
    <dbReference type="GeneID" id="14212120"/>
    <dbReference type="KEGG" id="clg:Calag_0860"/>
    <dbReference type="eggNOG" id="arCOG00280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG05935">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_548158_0_0_2"/>
    <dbReference type="OMA" id="DETWRIV"/>
    <dbReference type="OrthoDB" id="25718at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="DUF87" evidence="2">
        <location>
            <begin position="222"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="497" mass="55867" checksum="07371051A8B1A424" modified="2013-03-06" version="1">MLTPFQIFDFIIGIIAFVSIFLILKNMRSGTDLALPLKIKPKKKGEVIEYEINGKKYAGIAYISDNLPRGGEDLPKRLIRIARSSRLSVSFISNMYNVNKSSLLKLIDEEMKKADLSFSTTNQTKYRERLRFLEDLYKEVARIGVPYIGSFGFIVWIDKDDRDSELYAESFRSLVEAEAQIKTRRISNIEEILSITNPMDTIDESTSFAITSADDIGEYEGIVIGEEYDEHGKTVLLSWPDHFKHHIGIFGPTGRGKTVLLAGIAMQLSLISSITKNPQSIIVIDPKGDLSSLLRKNADFYIEPGINDCVKIPRMNGLANKLIESSMKTGEGGKINLCEGHMEKKGLMVYNLSKMPNETRNVYASLLISSLALQASEEGFSTPLVLIIDETWRIVNNSYFHLEFAMREGRSKGLYTIYATQIPSDVGKNIIDNTGVKVIFGGFTNYYVDISQQIGIENADILKELPVGHMILKIENNREKTVKVIDFNKLLKKGENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC87</accession>
    <name>L0AC87_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="5">OPRT</shortName>
            <shortName evidence="5">OPRTase</shortName>
            <ecNumber evidence="2 5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrE</name>
        <name evidence="7" type="ordered locus">Calag_1025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232644.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1025"/>
    <dbReference type="EnsemblBacteria" id="AFZ70747">
        <property type="protein sequence ID" value="AFZ70747"/>
        <property type="gene ID" value="Calag_1025"/>
    </dbReference>
    <dbReference type="GeneID" id="14212285"/>
    <dbReference type="KEGG" id="clg:Calag_1025"/>
    <dbReference type="eggNOG" id="arCOG00029">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_2_0_2"/>
    <dbReference type="OMA" id="YVNCKPV"/>
    <dbReference type="OrthoDB" id="117225at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="6">
        <location>
            <begin position="46"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="5">
        <location>
            <begin position="120"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFZ70747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="200" mass="22239" checksum="EF3E3CB7A15BF6E6" modified="2013-03-06" version="1">MQEIDVISKILYETGSIKIGKFLLASGKYSSIYVDMRKMLGNVDGFKRIGNLLSQKVNEIKKVDNIDVIIGVATGGIPWASVTSYLINLPMAYVRQQKGHGLNNQIEGADVVNKHGLIIDDVSTTGESLINSAKTVRENKGIVNYSLVIVDRGQGSIENLRKENINLHYLFTLKQILESLLKQNIINDNTFNNIINELYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACE3</accession>
    <name>L0ACE3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232612.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0992"/>
    <dbReference type="EnsemblBacteria" id="AFZ70715">
        <property type="protein sequence ID" value="AFZ70715"/>
        <property type="gene ID" value="Calag_0992"/>
    </dbReference>
    <dbReference type="GeneID" id="14212252"/>
    <dbReference type="KEGG" id="clg:Calag_0992"/>
    <dbReference type="HOGENOM" id="CLU_2730126_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="71" mass="7847" checksum="E97E6625530F3FA9" modified="2013-03-06" version="1">MKGKGIMFSKVTFLQYLAMFGIPILLIISLILIPFHGIKYIRETILALIAIGSIAYGIIGLFEVYLKGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACF1</accession>
    <name>L0ACF1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232622.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1003"/>
    <dbReference type="EnsemblBacteria" id="AFZ70725">
        <property type="protein sequence ID" value="AFZ70725"/>
        <property type="gene ID" value="Calag_1003"/>
    </dbReference>
    <dbReference type="GeneID" id="14212263"/>
    <dbReference type="KEGG" id="clg:Calag_1003"/>
    <dbReference type="eggNOG" id="arCOG02560">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06052">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_386686_0_0_2"/>
    <dbReference type="OMA" id="GYMYVTN"/>
    <dbReference type="OrthoDB" id="111908at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="694"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="714" mass="75979" checksum="C1BA3D68FD438D87" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACF6</accession>
    <name>L0ACF6_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Type-5 uracil-DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_1008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232627.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1008"/>
    <dbReference type="EnsemblBacteria" id="AFZ70730">
        <property type="protein sequence ID" value="AFZ70730"/>
        <property type="gene ID" value="Calag_1008"/>
    </dbReference>
    <dbReference type="GeneID" id="14212268"/>
    <dbReference type="KEGG" id="clg:Calag_1008"/>
    <dbReference type="eggNOG" id="arCOG00905">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083279_0_0_2"/>
    <dbReference type="OMA" id="CVPPQNK"/>
    <dbReference type="OrthoDB" id="90493at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033958">
        <property type="term" value="F:DNA-deoxyinosine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10031">
        <property type="entry name" value="UDG-F5_TTUDGB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044147">
        <property type="entry name" value="UdgB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="46"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="219" mass="24735" checksum="3D4124C40C117362" modified="2013-03-06" version="1">MEDIEEINQKIISCRKCPRLINYINDVAKHPPKRFKDWNYWAKPVPSFGDKNAEIAIVGLAPAANGGNRTGRVFTGDHSGDWLFKALYETGFANKPTSISKDDGLEIKNIYITAVIHCAPPQNKPNKDEISNCLPYLLSELKLLKNLKVIITLGKIAFDTITNIYNVKYEFKHLAVYDLPGNKKLIASYHPSARNTNTGLMGWEQWVNVFKKAKELIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACH2</accession>
    <name>L0ACH2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232739.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1120"/>
    <dbReference type="EnsemblBacteria" id="AFZ70842">
        <property type="protein sequence ID" value="AFZ70842"/>
        <property type="gene ID" value="Calag_1120"/>
    </dbReference>
    <dbReference type="GeneID" id="14212380"/>
    <dbReference type="KEGG" id="clg:Calag_1120"/>
    <dbReference type="eggNOG" id="arCOG01869">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01870">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_833194_0_0_2"/>
    <dbReference type="OMA" id="DPNVWAF"/>
    <dbReference type="OrthoDB" id="93965at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002808">
        <property type="entry name" value="AdoCbi_amidolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036681">
        <property type="entry name" value="PgpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01955">
        <property type="entry name" value="CbiZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101307">
        <property type="entry name" value="SSF101307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="356" mass="39880" checksum="E823A30E45BA5120" modified="2013-03-06" version="1">MVNIKIIDNNLILEFDKEMNILTTVHINAITKSKHILINHVEKDFKTNDIEGFKKEVLKKLGLSLNTPVFLTAVDIKNYKIKENEFGGALITAGFEVPNCIYQKDLFNGMCGGTINIISWVNIKLTLNGLLDLFRTITETKCLASSDLLLRCESRASGTSSDGIGVAAEISNDGFMFSGLATYHGNAIAKLIYETLVSFNNEQTLLKRSLGISLEELVEQAMIIYKKAPVPNVDEKTVYNMIYSELNNELKDPNVWSYIIAARELDLRGVSNTFPYLNKEEFERDSKRIIADEALASSLSIYLSGFKGLTSTYWVDTIKDKENLKFSHLPMFEDDIVSALIGSTLSRIYDKLLGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACH5</accession>
    <name>L0ACH5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="9">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Calag_1401</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="9"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1401"/>
    <dbReference type="EnsemblBacteria" id="AFZ71109">
        <property type="protein sequence ID" value="AFZ71109"/>
        <property type="gene ID" value="Calag_1401"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1401"/>
    <dbReference type="eggNOG" id="arCOG01358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_4_2_2"/>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="OrthoDB" id="18705at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:N6-threonylcarbomyladenosine methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061712">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="14"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="143"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="378"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFZ71109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="447" mass="51387" checksum="69C207FC177066E9" modified="2013-03-06" version="1">MKASKLYIEGEILKKYYIETFGCALSEFDSSTMDSILSQNGYVKTEYPNDADIIIVNTCAVRLDTEAKIMKRLNEIKNYYGNARLIVSGCLAKARPSFISRVVPNASLVSPQNSTKILDVVKSENKVVLIEGNRDTDFMPTPPIEDSVATIMIEEGCVDNCSFCITKLARQTLKSYKPRVILDTIKKLVEKGVKEIRLTGQDIAAYGLDFNPKFRLDELINIILDKIKGEYRIRIGMMTPDKSIEIIDNLLELYKDERIFKFFHIPVQSGDNNMLKIMNRNYSIEEYKYLHNKIKSKYPNSLFATDIIVGHPGENEEAFQNTVKLVKELRFERVYLAQYSIRPRTKAASMEQVPEVIKKKRSLMLNKVIKEIEEEIYKNYIGKTYEVLITTHGFRENYVVGRLNNYFPVAIKGGDELIGKMALVRINKATYFDLRGEVIEELKVKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACI5</accession>
    <name>L0ACI5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232754.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1135"/>
    <dbReference type="EnsemblBacteria" id="AFZ70857">
        <property type="protein sequence ID" value="AFZ70857"/>
        <property type="gene ID" value="Calag_1135"/>
    </dbReference>
    <dbReference type="GeneID" id="14212395"/>
    <dbReference type="KEGG" id="clg:Calag_1135"/>
    <dbReference type="eggNOG" id="arCOG01320">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_3_2_2"/>
    <dbReference type="OMA" id="DAGGLIC"/>
    <dbReference type="OrthoDB" id="72536at2157"/>
    <dbReference type="UniPathway" id="UPA00275"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="232" mass="26503" checksum="1771BE765EEC49A0" modified="2013-03-06" version="1">MQSGKDIDKAIESWKNGYPILLYDSSNRESEIDMVYHASKVTPESIYKLRNEAGGLICFATSWNIAKELGLIWGDELIAKIPNLKPLTEKLLFYKDRPAFTIWVNHVNVRTGISDNDRALTIRELYKTIKLFVEDKRNEAIKKFVEEFQAPGHVPLLAARNLKERKGHTELSIYLSLLAKMEPATTFAEMLDFGVSLSLEKAEKYAKKMGYVLISGKEVLEACEGEKMCWDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD21</accession>
    <name>L0AD21_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232847.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1233"/>
    <dbReference type="EnsemblBacteria" id="AFZ70950">
        <property type="protein sequence ID" value="AFZ70950"/>
        <property type="gene ID" value="Calag_1233"/>
    </dbReference>
    <dbReference type="GeneID" id="14212493"/>
    <dbReference type="KEGG" id="clg:Calag_1233"/>
    <dbReference type="eggNOG" id="arCOG02702">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_16_1_2"/>
    <dbReference type="OMA" id="VECPLAE"/>
    <dbReference type="OrthoDB" id="67424at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="39"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="194" mass="22295" checksum="B126AFA1F98C591B" modified="2013-03-06" version="1">MFAENFWRHHSGMHYFNNDEMIKDVLGKIQINEGSYIADLGSGIGRFTIPIAKIVGDKGKVFAIDLSKESLMILKENAEKENLNNIEIIYGDISKKIPLNDKYIDIAFMANVFHDIIYEGNEMNVFNEIKRILKDNGKWIILEFKKTHGPPGPPFMMRISYEELSKMLSNNGFSVKYLGEIGKYHYLVEAKPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD37</accession>
    <name>L0AD37_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1343</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232949.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1343"/>
    <dbReference type="EnsemblBacteria" id="AFZ71052">
        <property type="protein sequence ID" value="AFZ71052"/>
        <property type="gene ID" value="Calag_1343"/>
    </dbReference>
    <dbReference type="GeneID" id="14212603"/>
    <dbReference type="KEGG" id="clg:Calag_1343"/>
    <dbReference type="eggNOG" id="arCOG01257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="554" mass="59946" checksum="43450E7634234D51" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD82</accession>
    <name>L0AD82_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1296"/>
    <dbReference type="EnsemblBacteria" id="AFZ71010">
        <property type="protein sequence ID" value="AFZ71010"/>
        <property type="gene ID" value="Calag_1296"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1296"/>
    <dbReference type="eggNOG" id="arCOG13709">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1399680_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="194" mass="23257" checksum="107A638D93B54E4F" modified="2013-03-06" version="1">MKFMEDNTKNIIKEYFNKSFNFIFIDLIIDIFLLLFSLYFVSSYLIKITIYALIIASTVFLITILYYSYNNFKNKIAILKECCNGEISYNKKRNLLTCSYSNNLKICLSLDYDRVYINKIDKYIKDTEDTRDFYCVRFEDGKIERNEEYMKTFQGIFRLIDKDNIALFQGKTIIIDKIDKTRIKYGIERLVNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADD4</accession>
    <name>L0ADD4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proline--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="6">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">proS</name>
        <name evidence="8" type="ordered locus">Calag_1415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233019.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1415"/>
    <dbReference type="EnsemblBacteria" id="AFZ71122">
        <property type="protein sequence ID" value="AFZ71122"/>
        <property type="gene ID" value="Calag_1415"/>
    </dbReference>
    <dbReference type="GeneID" id="14212675"/>
    <dbReference type="KEGG" id="clg:Calag_1415"/>
    <dbReference type="eggNOG" id="arCOG00402">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_4_2_2"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="14454at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="42"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ71122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="482" mass="56353" checksum="91FBA929A9237999" modified="2013-03-06" version="1">MVEPKKEKKERDFSQWYDWILERAEIYDYGRYPIKGMGIWLPYGFQIRKKTIDLIRDLLDSTGHEEILFPLLIPKWMLEKESEHIRGFEEEVFWVTHGGLEELDQKLALRPTSETIITYYESLWYQSYRQLPRKLYQIVSMFRYETKATRPLIRLREVTTFKEAHTIHDTFESAEQQIKEAIDIYKKFFDELGIPYIISKRPDWDKFAGALYTIAFDTMMPDGRTLQIGTVHNLGQSFSKAFNYKIQLKDESFDHPWQTSYGISDRVVATIIGVHGDDNGLVLPPNIAPTQVIVIPIPSSDESETKSIIDYSRKILNELLESKVRAKIDDRSEMTPGEKYYYWEAKGVPVRIEIGSRELRTHNLTVVRRDTLSKITIGEKELINEINHIMNSIQNNLYERAWKDLKQKIYETDNLNEARQYLDKKGIVEIPWCGKESCANKVMESLGAKSLGTPWPSQKISGKKCPICGEKAQTTMRYARQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADE2</accession>
    <name>L0ADE2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATPase, Rnase L inhibitor (RLI) like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232967.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1361"/>
    <dbReference type="EnsemblBacteria" id="AFZ71070">
        <property type="protein sequence ID" value="AFZ71070"/>
        <property type="gene ID" value="Calag_1361"/>
    </dbReference>
    <dbReference type="GeneID" id="14212621"/>
    <dbReference type="KEGG" id="clg:Calag_1361"/>
    <dbReference type="eggNOG" id="arCOG00187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017344_4_1_2"/>
    <dbReference type="OMA" id="ISYKPQY"/>
    <dbReference type="OrthoDB" id="13010at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="PTHR19248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="68"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="332"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="604" mass="67836" checksum="0B22D6728E0F2604" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADG0</accession>
    <name>L0ADG0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Archaeal ribosomal protein S17P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1376"/>
    <dbReference type="EnsemblBacteria" id="AFZ71085">
        <property type="protein sequence ID" value="AFZ71085"/>
        <property type="gene ID" value="Calag_1376"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1376"/>
    <dbReference type="eggNOG" id="arCOG04096">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_0_3_2"/>
    <dbReference type="OMA" id="DPECPWH"/>
    <dbReference type="OrthoDB" id="108145at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_S17_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="117" mass="13350" checksum="7CFBF7EB6E97E04A" modified="2013-03-06" version="1">MGVSLMPEQKAIKNLQIPGVSPPSKSCSDPNCPWHGSLRVRGVLLEGIVEKFRAKGSAVVRHEYLYYERKYKRYEWRKTKKLVHVPECLDIKEGDKVVIGETKPLSKTIKFVILGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADG7</accession>
    <name>L0ADG7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233059.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1458"/>
    <dbReference type="EnsemblBacteria" id="AFZ71162">
        <property type="protein sequence ID" value="AFZ71162"/>
        <property type="gene ID" value="Calag_1458"/>
    </dbReference>
    <dbReference type="GeneID" id="14212718"/>
    <dbReference type="KEGG" id="clg:Calag_1458"/>
    <dbReference type="eggNOG" id="arCOG04298">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138382_0_0_2"/>
    <dbReference type="OMA" id="FGIAFCE"/>
    <dbReference type="OrthoDB" id="94911at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007153">
        <property type="entry name" value="Adenosine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036902">
        <property type="entry name" value="Ta1353-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36155">
        <property type="entry name" value="PTHR36155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04008">
        <property type="entry name" value="Adenosine_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103165">
        <property type="entry name" value="SSF103165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="161" mass="18051" checksum="3006388E1BC01B28" modified="2013-03-06" version="1">MDYQILDIPVPEGTNVIIGRSHFIKTVEDLYETMVTSCPSSKFGIAFCEASGKRLIRYEGNDKDLINHAINACNIISSGHIFVIYLKDSWPINVLNSIKSVQEVTHVYVATSNPVKVAVIDSGESRIILGFSDGFKPLGVEKDEDKIERKELLRKFGYKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADI6</accession>
    <name>L0ADI6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA splicing endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1386"/>
    <dbReference type="EnsemblBacteria" id="AFZ71095">
        <property type="protein sequence ID" value="AFZ71095"/>
        <property type="gene ID" value="Calag_1386"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1386"/>
    <dbReference type="eggNOG" id="arCOG01701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1529139_0_0_2"/>
    <dbReference type="OMA" id="AMIDNEV"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="SSF53032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_int_endo" evidence="3">
        <location>
            <begin position="85"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ71095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="175" mass="20339" checksum="BA91E79A46FE6CB8" modified="2013-03-06" version="1">MIKMKNAKDTYLELNIEEEKLMVKNCYDNEFCEQLIKNDLIVNNSVNLLEGIYLIAIEKAMIDNEVGWGKALELIDRYKIPLHIFLVYYDLRKRGRRVWIGPRDNTLISETHKLKKIEVFVLSEGSPITTNKIANWSELAVADSHIPIIAIVDKNGEITYYESRIYMLNSLSNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADK1</accession>
    <name>L0ADK1_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1506"/>
    <dbReference type="EnsemblBacteria" id="AFZ71207">
        <property type="protein sequence ID" value="AFZ71207"/>
        <property type="gene ID" value="Calag_1506"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1506"/>
    <dbReference type="eggNOG" id="arCOG01759">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131318_0_0_2"/>
    <dbReference type="OMA" id="MVPSHAI"/>
    <dbReference type="OrthoDB" id="101778at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="2">
        <location>
            <begin position="10"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="167" mass="18788" checksum="F7A6C43F0B315FA7" modified="2013-03-06" version="1">MSENLLRVTNVQTYYKVIQDMGSGFGTYIIGMSLSLEDGRMFSLVNIPADVAEAIRIYNDGEVPPRRQSLFSFLMNHEEFKDIIGKTLKRIIIDELDQTNGLYTASVEFESEGLNISIKMIPSHAIYLGIISGKPIYVSKKLADMEEQNQEHGGSNDDEDDDEGEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7I6</accession>
    <name>L0A7I6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0041"/>
    <dbReference type="EnsemblBacteria" id="AFZ69833">
        <property type="protein sequence ID" value="AFZ69833"/>
        <property type="gene ID" value="Calag_0041"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0041"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="ICGFDVQ"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ69833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="286" mass="31392" checksum="9BD734FB60602DA6" modified="2013-03-06" version="1">MPNIVETRKLTKIYGNGIKALDELDLKLNSRISCIIGRNGAGKTTLVKILSTQLRQTSGEAFVMGYDVIKDRHKLRKMICSIPQESKPAGISSPLEHLVMYLTARGFPIRDSFNLAKMALKEVGLGDFIDTSTDELSGGMKRKVFVAMALASQAEVIFLDEPTVGLDPISRLEVWGAIRQLKGNVILTTHYMEEAQALCDQIAIIDKGKTIKVGNLEELMEPLKGKVRVEGIGNISIGELKISYVTPEEAKKLISEVKINGSNKISIKPVSLEDVLILSGVEIENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7R2</accession>
    <name>L0A7R2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginase family hydrolase, arginase/agmainase/formiminoglutamate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0076</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231764.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0076"/>
    <dbReference type="EnsemblBacteria" id="AFZ69866">
        <property type="protein sequence ID" value="AFZ69866"/>
        <property type="gene ID" value="Calag_0076"/>
    </dbReference>
    <dbReference type="GeneID" id="14211336"/>
    <dbReference type="KEGG" id="clg:Calag_0076"/>
    <dbReference type="eggNOG" id="arCOG01700">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_0_2_2"/>
    <dbReference type="OMA" id="GTMFRQI"/>
    <dbReference type="OrthoDB" id="52310at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ69866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="304" mass="34684" checksum="F7261007BC7460DC" modified="2013-03-06" version="1">MNYLEEPSNSFIRDEKDKKIKDFEKSIPLIGIPWDWSTAGKPGARFAPQSIRNELYSLRTDVYELNEIKFGFNDLGNVRISPGDLNETSRRIISVCDDVFKKIKEKNPVIFLGGDHSITKSILLSLSKFYNKIGLIIFDAHYDLREVKEGLTSGSWLNELLKDNKEKFNVIEIGISNYSNPSYMKEIAKKYGIKVFYRDQIIDDLKDVFYEINKVKENTDGIYISIDMDHLDQSFAPGVNSPTALGMYPHETIKIINEITRNSKILGIDTTEVSPPYDINNNTSRLAAKLLLYSINSYLGNKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7W6</accession>
    <name>L0A7W6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyroglutamyl peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231824.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0139"/>
    <dbReference type="MEROPS" id="C15.001"/>
    <dbReference type="EnsemblBacteria" id="AFZ69926">
        <property type="protein sequence ID" value="AFZ69926"/>
        <property type="gene ID" value="Calag_0139"/>
    </dbReference>
    <dbReference type="GeneID" id="14211399"/>
    <dbReference type="KEGG" id="clg:Calag_0139"/>
    <dbReference type="eggNOG" id="arCOG05850">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043960_4_0_2"/>
    <dbReference type="OMA" id="KLAYNHK"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PTHR23402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="195" mass="22377" checksum="AE7C1A24808290B5" modified="2013-03-06" version="1">MKKVLLTGFEPFLEFNYNPSGEIAKKLNNYENEKYKIYGLELPVVHKEAIKILENNFYKIDPDLLLGMGLAPGATGIRIERIAINSYYFNDGNEIEDNIENGPEALYTNLPVDSIRKKLWSKGIPAYYSFHAGTYLCNEVFYKIMRLAYNKGIKGGFIHIPLTHKQVIAMKKFNYPSMDENILIDAIKLIIEESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0A7Y7</accession>
    <name>L0A7Y7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231844.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0160"/>
    <dbReference type="EnsemblBacteria" id="AFZ69946">
        <property type="protein sequence ID" value="AFZ69946"/>
        <property type="gene ID" value="Calag_0160"/>
    </dbReference>
    <dbReference type="GeneID" id="14211420"/>
    <dbReference type="KEGG" id="clg:Calag_0160"/>
    <dbReference type="eggNOG" id="arCOG00480">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043611_0_2_2"/>
    <dbReference type="OMA" id="YDAHIAM"/>
    <dbReference type="OrthoDB" id="54073at2157"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ69946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="311" mass="34867" checksum="89AF47DD4180DC95" modified="2013-03-06" version="1" precursor="true">MIKKWFKALSPVTLLSAFSSVTLGTAIAWYKTGKIIWAFYFITLIALILAQAGVNLINDYIDYKTNIDLLYRKTGLFHRNNAIVDLNLNPKIVRSVGYSMIFIALLSGIYLALRVGIPVIVIGIIGLFLGVIYSEPPFNLKYRGYGEIIAAIVMGPLVVWGSYIVQTGNLSTLYPLLVGIINGSFTFLILLGSSSLKAETYKKLNKKNIIIVMGNKIRYVVYSAIGLLYLSIILSSLFDFIPLIALISLIFIPNTLKLTRPLLKIEDVNKKWDELRQLWAGPFSARILILIIIIVSIIITRFIRILDISIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A803</accession>
    <name>L0A803_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate uptake regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231896.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0216"/>
    <dbReference type="EnsemblBacteria" id="AFZ69998">
        <property type="protein sequence ID" value="AFZ69998"/>
        <property type="gene ID" value="Calag_0216"/>
    </dbReference>
    <dbReference type="GeneID" id="14211476"/>
    <dbReference type="KEGG" id="clg:Calag_0216"/>
    <dbReference type="eggNOG" id="arCOG00318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069302_1_0_2"/>
    <dbReference type="OMA" id="MPWIERN"/>
    <dbReference type="OrthoDB" id="38423at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="10"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="325" mass="35817" checksum="BE76EF69CBFC02B8" modified="2013-03-06" version="1">MGIVARKVQRLGASSYVITLPHTWIEANNIKPGDTVYIVDDDNKLSIIPSQKDEEKSKTVYEMDLGKIPIPEIASLAIYCLYVHNLGDTIINMGPMGKKGVESAKQAALSLLGLDVFELGESRIMIRPVIDDSKIEIKQVIKGLGMIVSDITGILRDALNGLDVTQSLQLSQKDLLKYQHLVERHVVDTMLHGKSDVRLHALVLGSGLLGVVGYIMWDAADKANKIKIKSEEISSLITNIKDILPQLGSIIAQPSIKRTQELLLQIMAITMDVEEKSINSKDSRETMILTKVADALKLLNVILYVITCSAVTSEEYLRKSNSTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>L0A839</accession>
    <name>L0A839_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metal-dependent carboxypeptidase</fullName>
            <ecNumber evidence="1">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M32 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0214"/>
    <dbReference type="MEROPS" id="M32.002"/>
    <dbReference type="EnsemblBacteria" id="AFZ69996">
        <property type="protein sequence ID" value="AFZ69996"/>
        <property type="gene ID" value="Calag_0214"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0214"/>
    <dbReference type="eggNOG" id="arCOG04247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032916_1_1_2"/>
    <dbReference type="OMA" id="EFGHALY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="PTHR34217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ69996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="499" mass="58749" checksum="199CE05974F87506" modified="2013-03-06" version="1">MVNMFENAVIREILEKYKRLWAIGHSMALMGWDNETYMPPKGSEERGYAIAEMSTLYQEMLLNESFVQLVEKGKNQENLNDYEKGVVRVLDREISILKKIPPSLVYEMSKTSEEAFHAWKLAREKNDFSIFSPYLEKIIKLNIEKAERLGYENEPYDALLDLFEEGLRTKDIIGIFDNLRSNLRSLLDKVISQKYYYFNSPLEGIKYEREKMEKVNNEVLNLLNFPWDRARLDVSPHPFTQGMGINDVRITTRYEGYDFKRSLFSVIHEFGHATYELQIDENLKMTPIGGGVSLGIHESQSRFWENIIGRSYQFTQVIKPILDKHLDFTKGYSEEDLYRYFAMVKPSLIRTEADELTYNFHILLRFELERLMLKGEVKVNDLPEIWNQYMEDLLGIRPKSYSEGILQDVHWSHGDLGYFPTYTLGNIVAAQVRNSLLKSISLYDLILEKKFNDIKASLRELIHKYGSTYRPKDLLLMKLGESYNQEYLINYLREKYLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0A884</accession>
    <name>L0A884_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Calag_0265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231944.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0265"/>
    <dbReference type="EnsemblBacteria" id="AFZ70046">
        <property type="protein sequence ID" value="AFZ70046"/>
        <property type="gene ID" value="Calag_0265"/>
    </dbReference>
    <dbReference type="GeneID" id="14211525"/>
    <dbReference type="KEGG" id="clg:Calag_0265"/>
    <dbReference type="eggNOG" id="arCOG00536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_1_2_2"/>
    <dbReference type="OMA" id="NGKAIEW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="94" mass="10940" checksum="93C4162FC45DF112" modified="2013-03-06" version="1">MIIKVKFILDYYKFIGKHELLLDVKNNSTLLDIIDYINNNIKNGFKEKIINGNEIKYPNMILINGRRAEFLNGLNTSLNENDEILFSPLAYFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A897</accession>
    <name>L0A897_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231959.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0281"/>
    <dbReference type="EnsemblBacteria" id="AFZ70061">
        <property type="protein sequence ID" value="AFZ70061"/>
        <property type="gene ID" value="Calag_0281"/>
    </dbReference>
    <dbReference type="GeneID" id="14211541"/>
    <dbReference type="KEGG" id="clg:Calag_0281"/>
    <dbReference type="eggNOG" id="arCOG13715">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1217524_0_0_2"/>
    <dbReference type="OMA" id="HIGRTEE"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="227" mass="25671" checksum="41DE0C8839C4361C" modified="2013-03-06" version="1">MIPQAGLGNQIIYLNINAILYLISGIVALSVSYVSFKYSKIIEESLLNYISFGFILLGLGLVIQGSLMILLSFNIARFSENIKTIYISSVMYLILQVIAYIIISVGYSKKAYWNSGEALISIIFTKKREYFLLGAYIFDASQIIIIFLLSLIVFTGYLVHMKNKNTFSLLVLIAFSLMLISHITYLLSSLMFSIDDYFIANIIQFLGFLSLLIFLIRSGHIGRTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8C2</accession>
    <name>L0A8C2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">rRNA biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231996.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0321"/>
    <dbReference type="EnsemblBacteria" id="AFZ70098">
        <property type="protein sequence ID" value="AFZ70098"/>
        <property type="gene ID" value="Calag_0321"/>
    </dbReference>
    <dbReference type="GeneID" id="14211581"/>
    <dbReference type="KEGG" id="clg:Calag_0321"/>
    <dbReference type="eggNOG" id="arCOG01923">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_1_0_2"/>
    <dbReference type="OMA" id="REWYSLH"/>
    <dbReference type="OrthoDB" id="89321at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D RNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="PTHR10894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="SSF89124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nop" evidence="3">
        <location>
            <begin position="263"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="412" mass="46988" checksum="DF1D282C61DC1E39" modified="2013-03-06" version="1">MKIYIVDTINGSYGLNEKGEIVAYEFLPKNYDEAIEQIIKIYKGDVSQTFIKLLDKIIEKKPEEIVVESESEAKYINQKGIKAIVEESNPIAINFRHEIGKKAVNYEFSKDEPEFYNWYFNIVYEFTRRMLRGAAQKRDLLVAQAIRAIDDLDKSVNLYATRLREWYSVHFPELNDLIEDHELYSMLVSELGPRSNFTVENIMNLGLSESKSKKIEEAAKKSIGADVSDKDLEAMLTLAKITNQMYNLRKDLDQYATSVMKEVAPNITELVGPLLGARLISIAGGLERLATMPASTIQVLGAEKALFRALKTGGRPPKHGIIFQYPEIYKSPKWQRGKIARALAAKLAIAAKVDAFSGRFIGDKLKEELEKRIEEIKKIYASPKKKETQKQSFQRPQGRGKPSKYKHGRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8K0</accession>
    <name>L0A8K0_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Ser/Thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0425"/>
    <dbReference type="EnsemblBacteria" id="AFZ70193">
        <property type="protein sequence ID" value="AFZ70193"/>
        <property type="gene ID" value="Calag_0425"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0425"/>
    <dbReference type="eggNOG" id="arCOG01182">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095575_0_0_2"/>
    <dbReference type="OMA" id="ESTSHGC"/>
    <dbReference type="OrthoDB" id="104998at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="263" mass="30466" checksum="4F179001D72CFD59" modified="2013-03-06" version="1">MDKKLSLLDSCLDDKHINEKDTISLICYPNSNKCDTYYRLNQIDTLGIEKLCNYGNIMINGNKYRNFHILGKGHSSIVLLGYVKKIGLKVIKIRRVDSKRSELINEGKILEKLSKYGISPKVYGYSRDFLIMDYVGEINLGYVLNNENKSNIINSLIESLKSIKLLDYTNIIHNELNRPWKNIYFPNYPNYFPALIIDFESYSEGCGNLNKFIGGIIGKLNITRFSKNLLELLAEYKNKNCDPLFFDKIIKELLFIINTCFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8S9</accession>
    <name>L0A8S9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70283">
        <property type="protein sequence ID" value="AFZ70283"/>
        <property type="gene ID" value="Calag_0520"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0520"/>
    <dbReference type="HOGENOM" id="CLU_2802005_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="67" mass="8161" checksum="D2324C45C93B8455" modified="2013-03-06" version="1">MKEVRIDANDTKENFDHLNLYYFLTNYNTCACFMYYYKYFIISFNVVILKNIEINDKSKKLKIIELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8V5</accession>
    <name>L0A8V5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl13</name>
        <name evidence="5" type="ordered locus">Calag_0553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232211.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0553"/>
    <dbReference type="EnsemblBacteria" id="AFZ70313">
        <property type="protein sequence ID" value="AFZ70313"/>
        <property type="gene ID" value="Calag_0553"/>
    </dbReference>
    <dbReference type="GeneID" id="14211813"/>
    <dbReference type="KEGG" id="clg:Calag_0553"/>
    <dbReference type="eggNOG" id="arCOG04242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076922_1_0_2"/>
    <dbReference type="OMA" id="GMLPWKT"/>
    <dbReference type="OrthoDB" id="87367at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_L13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="PTHR11545:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="148" mass="16749" checksum="2F3E3C191DC6E4DB" modified="2013-03-06" version="1">MEEIVIDGSNTILGRLASHVAKLLLEGKKVVVLNSEKIAVSGDPTKLIQFYKDTILNVKTHYSHKWRPKRARSPTRLFKKTVSGMLPKNNKKGEEALKRLIVYVGVPKEYKNKEAIKVQEASVEKLGGRYTTLQVIAENMGWKVNFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0A8Z1</accession>
    <name>L0A8Z1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232229.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0572"/>
    <dbReference type="EnsemblBacteria" id="AFZ70331">
        <property type="protein sequence ID" value="AFZ70331"/>
        <property type="gene ID" value="Calag_0572"/>
    </dbReference>
    <dbReference type="GeneID" id="14211832"/>
    <dbReference type="KEGG" id="clg:Calag_0572"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_2_2_2"/>
    <dbReference type="OMA" id="MIVYGPY"/>
    <dbReference type="OrthoDB" id="125556at2157"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="2">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="81" mass="9130" checksum="5DC950F6404D5BE6" modified="2013-03-06" version="1">MSEAIVMINADVGKENDIFNKLNEMQEVKKVYMVYGIHDIIAFVEAESMDKLRGLITDKIRKLDGVKSTLTSIVVVGKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A906</accession>
    <name>L0A906_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232244.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0589"/>
    <dbReference type="EnsemblBacteria" id="AFZ70346">
        <property type="protein sequence ID" value="AFZ70346"/>
        <property type="gene ID" value="Calag_0589"/>
    </dbReference>
    <dbReference type="GeneID" id="14211849"/>
    <dbReference type="KEGG" id="clg:Calag_0589"/>
    <dbReference type="eggNOG" id="arCOG00453">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1071999_0_0_2"/>
    <dbReference type="OMA" id="NDINTYH"/>
    <dbReference type="OrthoDB" id="134910at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="259" mass="29207" checksum="1A2B5A3A623F6954" modified="2013-03-06" version="1">MIGDVVKKFFARGQYKETGLSQEGINYDEILAQLGLVKMELDRIKTTIINEIQNYYEKMVSSKKLNNTEDMEMNAAEIVLKKRVLKAVLAYGNMIELTIRRIQDTRSLESIVKVLTPLRYAMSAMDEYLTGFAPEAVTSLSNVLEETENVIRKTGIIANSMPQGKSVSELVPEASELITNAMAKAQKEAEQLSPRVPETFDPDIIERKVFEYIKNKNGVLSLRKASEELGIPLDVIRETLYRLEARGIIKVDLPNQSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A944</accession>
    <name>L0A944_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UbiD family decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0158"/>
    <dbReference type="EnsemblBacteria" id="AFZ69944">
        <property type="protein sequence ID" value="AFZ69944"/>
        <property type="gene ID" value="Calag_0158"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0158"/>
    <dbReference type="eggNOG" id="arCOG01671">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023348_4_1_2"/>
    <dbReference type="OMA" id="SYQQFWG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="494" mass="55773" checksum="E45B9E115151B7D9" modified="2013-03-06" version="1">MDPLKDMREYIQWLEKNNILIKVNDELSPILEIPAFLRKVMYSKGPAVLFEKIKGFENWKIAGNLFPNLDLIKSTLSVNNLEEIGNRMIEPITSPIPFGLLDKVKALGEVSKLSSYFPKKTSKAAFTENIIDGKDNPLEKIPFFKTWPNDGGRYATYPMVITMDQDKKIINMGVYRMMIIDGNKAVIHWQIHKRGALMHMKAIESSKEEIPIAVAIGSDPGTMLASVSPVPYPIDKSLFAGIIRGKGIELYELDNGIMVPSNAEIILEGRVLTNKLVEEGPFGDHWGYYDKPIEKYPLFIVDKAYIRNDPIYFGSVVGLPPLEDAVLGKAIERMFKPIMQVLLPEIIEINYPVEGVFQGMLIVSIKKRYPGQAKKVMSALWGIGQSSLTKIIIVVDNDVDPHDLGKVIWSISCNVNPERDVLILSNSHSDALDPSNLYPSFGSKLGIDATRKMPEENWGKPWPKIVEEDEEILRKIEPLVNNYLKKVQNNPNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9A4</accession>
    <name>L0A9A4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S27ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps27ae</name>
        <name evidence="8" type="ordered locus">Calag_0222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231902.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0222"/>
    <dbReference type="EnsemblBacteria" id="AFZ70004">
        <property type="protein sequence ID" value="AFZ70004"/>
        <property type="gene ID" value="Calag_0222"/>
    </dbReference>
    <dbReference type="GeneID" id="14211482"/>
    <dbReference type="KEGG" id="clg:Calag_0222"/>
    <dbReference type="eggNOG" id="arCOG04183">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179743_1_0_2"/>
    <dbReference type="OMA" id="CGYTIFE"/>
    <dbReference type="OrthoDB" id="123606at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00777">
        <property type="entry name" value="Ribosomal_S27ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_S27a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022845">
        <property type="entry name" value="Ribosomal_S27ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ribosomal_S27" evidence="7">
        <location>
            <begin position="10"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="61" mass="7226" checksum="A02307335AA16DC9" modified="2013-03-06" version="1">MAKEKPKAYIHTLYEVDYNNKSVSLKNKKCPRCGNIMAHHLKPVERYQCGYCKYTEFVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9C9</accession>
    <name>L0A9C9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231927.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0247"/>
    <dbReference type="EnsemblBacteria" id="AFZ70029">
        <property type="protein sequence ID" value="AFZ70029"/>
        <property type="gene ID" value="Calag_0247"/>
    </dbReference>
    <dbReference type="GeneID" id="14211507"/>
    <dbReference type="KEGG" id="clg:Calag_0247"/>
    <dbReference type="eggNOG" id="arCOG00826">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_36_1_2"/>
    <dbReference type="OMA" id="FYVMPEY"/>
    <dbReference type="OrthoDB" id="101975at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="161" mass="18576" checksum="A6805D46FF1EC7D8" modified="2013-03-06" version="1">MSIEKINIREINENDLSQVVELVVRLKSVNEELDPNFKIVNNIYDVVSKYVKDSVNNENVVFLVAEDENEKTIAGIIRFIIIDRLFYEPRIKAEITDFYVKPIYRRKRLGAMLLQKAIEYAKLKGAGIVTAIYPAGNNIADSFYDKQGFISLNKEKYKSCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9E8</accession>
    <name>L0A9E8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_0752</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232393.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0752"/>
    <dbReference type="EnsemblBacteria" id="AFZ70496">
        <property type="protein sequence ID" value="AFZ70496"/>
        <property type="gene ID" value="Calag_0752"/>
    </dbReference>
    <dbReference type="GeneID" id="14212012"/>
    <dbReference type="KEGG" id="clg:Calag_0752"/>
    <dbReference type="eggNOG" id="arCOG00328">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_6_0_2"/>
    <dbReference type="OMA" id="GNQKSPY"/>
    <dbReference type="OrthoDB" id="35869at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_B_exo1" evidence="7">
        <location>
            <begin position="30"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B" evidence="6">
        <location>
            <begin position="380"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="799" mass="92311" checksum="7266085711C8D429" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9G7</accession>
    <name>L0A9G7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231962.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0284"/>
    <dbReference type="EnsemblBacteria" id="AFZ70064">
        <property type="protein sequence ID" value="AFZ70064"/>
        <property type="gene ID" value="Calag_0284"/>
    </dbReference>
    <dbReference type="GeneID" id="14211544"/>
    <dbReference type="KEGG" id="clg:Calag_0284"/>
    <dbReference type="eggNOG" id="arCOG04762">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040971_1_0_2"/>
    <dbReference type="OMA" id="IHFAEQR"/>
    <dbReference type="OrthoDB" id="43299at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="427" mass="49030" checksum="092C6A04DC4000D6" modified="2013-03-06" version="1">MKGPIIIFGADGYIGWPLALHLGVKYDIPIILADNFSTRALVKSVKSDSLTPIKSMSERLKAYEETFGKDNLIFEPVDARDPEQVDHLISKYKPEAVVHLAQQRSAPFSMIDQEHVLYTEVNNVVANLNIMFSMIRHTPGAHLLKMGSMGEYGTPNIEITEGDIEIEYKNRKTKVMFPRMGQSYYHLTKIFDTYNLILSNKLHGIRATDVMQGVVYGTRTDEIVNEALETRFDFDSTWGTVINKYVVQAVVLNELLLYGKGKQTRGFLSLYDSINALTLLLENPPKEGQYRVVNQLDEIYNTTELAEKVIEIANEFGIKPKIRTIENPRVEAEDHFYAVEHKILPSLGFYRKKNIKDVIREIFETVIKYKYRAEYAKDLIYPTVKWKNLKDMKSSIFPMPEQYMKVLSRSEILKYFAPSIEVSLGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9I1</accession>
    <name>L0A9I1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232450.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0812"/>
    <dbReference type="EnsemblBacteria" id="AFZ70553">
        <property type="protein sequence ID" value="AFZ70553"/>
        <property type="gene ID" value="Calag_0812"/>
    </dbReference>
    <dbReference type="GeneID" id="14212072"/>
    <dbReference type="KEGG" id="clg:Calag_0812"/>
    <dbReference type="HOGENOM" id="CLU_968383_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="287" mass="33871" checksum="A3C607F3E0A132F8" modified="2013-03-06" version="1">MGRFHTSIGTILNYYFPINEKEAIEKLNEIANGSVYQFDDMYISRPNWLYYYDSQNDKLYDINTIYKMLDSHPPINIDIPDPGRRPDALDVLILSALGANAIDNYRLLIEAFKGPSPIKKFKPYSSFRFHLKHANLYSRGGAFLPKIGLNSFNLRLDEPMPFTSGYVLLKGSSKNIRSLFKRLLAFPFVGQIFLGSNSIYFNYVIHTNYFDTTIVNEYRQYDWDEIIQFNLLGRDIKERYLLPFREYDPILKQWIPNSNLDEIVRKKAKLSDFEKWYNEHYLNEKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9I6</accession>
    <name>L0A9I6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231977.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0300"/>
    <dbReference type="EnsemblBacteria" id="AFZ70079">
        <property type="protein sequence ID" value="AFZ70079"/>
        <property type="gene ID" value="Calag_0300"/>
    </dbReference>
    <dbReference type="GeneID" id="14211560"/>
    <dbReference type="KEGG" id="clg:Calag_0300"/>
    <dbReference type="eggNOG" id="arCOG05276">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120482_0_0_2"/>
    <dbReference type="OMA" id="MRLWSIH"/>
    <dbReference type="OrthoDB" id="103700at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004260">
        <property type="entry name" value="Pyr-dimer_DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03013">
        <property type="entry name" value="Pyr_excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="144" mass="17312" checksum="F03CB89FA1F42D9F" modified="2013-03-06" version="1">MRLWSIHPKYLDTKGLLALWREGLLAKSVLEGKTKGYINHPQLDRFKKSENPIAYINAYLYEIYLEAQRRGYNFNKNKVKSEKIEKKLLVTNKQVEYEFDHLLKKLKSRDINKYEEIKDIKMIEVHPIFQIVEGEIESWERVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9J4</accession>
    <name>L0A9J4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular solute-binding protein, family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_0827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232465.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0827"/>
    <dbReference type="EnsemblBacteria" id="AFZ70568">
        <property type="protein sequence ID" value="AFZ70568"/>
        <property type="gene ID" value="Calag_0827"/>
    </dbReference>
    <dbReference type="GeneID" id="14212087"/>
    <dbReference type="KEGG" id="clg:Calag_0827"/>
    <dbReference type="eggNOG" id="arCOG01533">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319962_0_0_2"/>
    <dbReference type="OrthoDB" id="6658at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="362"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="956" mass="106235" checksum="A32F343638F3169F" modified="2013-03-06" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9K7</accession>
    <name>L0A9K7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ69822">
        <property type="protein sequence ID" value="AFZ69822"/>
        <property type="gene ID" value="Calag_0029"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0029"/>
    <dbReference type="HOGENOM" id="CLU_2985471_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ69822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="57" mass="6960" checksum="C16227C0291F5DF4" modified="2013-03-06" version="1">MSYIDKNKERLEQEGLKKLEEIYKVFKEKIDNDYKSKIDELKSKYDLLVEEFAKRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9N4</accession>
    <name>L0A9N4_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_0066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231755.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0066"/>
    <dbReference type="EnsemblBacteria" id="AFZ69857">
        <property type="protein sequence ID" value="AFZ69857"/>
        <property type="gene ID" value="Calag_0066"/>
    </dbReference>
    <dbReference type="GeneID" id="14211326"/>
    <dbReference type="KEGG" id="clg:Calag_0066"/>
    <dbReference type="eggNOG" id="arCOG01351">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_1_2_2"/>
    <dbReference type="OMA" id="IEKQMDI"/>
    <dbReference type="OrthoDB" id="102435at2157"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homoserine_dh" evidence="8">
        <location>
            <begin position="148"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ69857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="320" mass="35924" checksum="A6DE7A0BD9121602" modified="2013-03-06" version="1">MKKAILIGFGNVGRTLAEELIKLDMVEIIGVITTKGFFKNNSNWKSWLKELIKSYPNYKHEESLLEDVLKELDIDIAFVTIPPSYYNGEPNLTIYNKLLSNRINIITADKTGLSLNYENLINEANKNRLFFGYRATVMAGTPATDVAKGLKGRNIKEIKAVLNATTNYILSLIEKGYTFEKALEEVKRLGLVEPDPKIDIEGFDAAAKIVIILNTLGIKSTINDVKRESLLSIDEKDIRNAIEKGRKIKYIASYNKNKTKVGLEEVDYESPLAKVSGNYNCISFVIDEDNIITLTGPAGPALNTARAMITDLYEFHEKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9T6</accession>
    <name>L0A9T6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231718.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ69820">
        <property type="protein sequence ID" value="AFZ69820"/>
        <property type="gene ID" value="Calag_0027"/>
    </dbReference>
    <dbReference type="GeneID" id="14211287"/>
    <dbReference type="KEGG" id="clg:Calag_0027"/>
    <dbReference type="HOGENOM" id="CLU_149108_3_1_2"/>
    <dbReference type="OMA" id="VLMISWI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002849">
        <property type="entry name" value="DUF131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01998">
        <property type="entry name" value="DUF131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="91" mass="9939" checksum="F7D226E37464B9A5" modified="2013-03-06" version="1" precursor="true">MANITTWLIIGFTLIVIGMLVIFSGTIYSSIQQNITQKFEVGGIIMIGPIPIIFGNSWKAINIAIILAIVLMILAIALIIINRTFLPKIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9W6</accession>
    <name>L0A9W6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein involved in the export of O-antigen and teichoic acid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0911"/>
    <dbReference type="EnsemblBacteria" id="AFZ70646">
        <property type="protein sequence ID" value="AFZ70646"/>
        <property type="gene ID" value="Calag_0911"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0911"/>
    <dbReference type="eggNOG" id="arCOG02209">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_539274_0_0_2"/>
    <dbReference type="OMA" id="YLGIYQF"/>
    <dbReference type="OrthoDB" id="41033at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="505" mass="56266" checksum="D7455F1144F432BB" modified="2013-03-06" version="1">MAMSIRAKVFKGMSKLLSANAAVTIMQFIFYLTIVRIIGFNGLGSYFDSVIILTFISLAATWESNGFSRFIIGYYQGGKEKEARYLYRLGIIIGLTSGFVIFIVMFLYSYQISSLLYRSPVYSNIVKILGIDIALSSYNSYAGIGPNALMKFGKMGIIQILWALGRYLTGMLLLFMGYGAFGLVVGWVIGDAINSIFYTMWSRELIFGKDTRSKLKPIISYAIPLVLGSLIVTLLSNVDKLFVLYKLGLAELGIYSTIMLASSVPQMLPNSIAASLSPALLGLEEKNGLNKEIVEKSIRYTTILSIPFLLLVGAMGKPLILLLLGQRFVHDWKAFTILTVGHALMSYDIPITIALSAKKDSKALALQSVIGAIIIGFLAPYLINLYFATGAAIAYVLSRFISFIAVALPRVRKHGLLKINLNEYLKVSISSLILLFGLLFVEYLTGFNVIYLPLYITLGILIIIFNFKFFKMLDKEDYTALNEVLPNNLKFFFEIIWSFLDLPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9W7</accession>
    <name>L0A9W7_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_0058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231748.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0058"/>
    <dbReference type="EnsemblBacteria" id="AFZ69850">
        <property type="protein sequence ID" value="AFZ69850"/>
        <property type="gene ID" value="Calag_0058"/>
    </dbReference>
    <dbReference type="GeneID" id="14211318"/>
    <dbReference type="KEGG" id="clg:Calag_0058"/>
    <dbReference type="eggNOG" id="arCOG01044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_8_2_2"/>
    <dbReference type="OMA" id="THVVVPY"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ69850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="224" mass="25842" checksum="C677C02B235DE097" modified="2013-03-06" version="1">MTHIPLYIDFDGLKVLVIGGGNVGARRSITFLESGAIVTVVASYFNESLLKINDKKLKLIKMEIKKPEDLNELIENNDLIVLTTDNEFINNGIYKIAKEKGKLINNATNSSMGNVIVPFRKKIYDNLEVAVTSLGYTGIAARRSLEKIENCLENDIEIKTLYDSMKEFKKYIKEKIKNPKIRYRLYFEVEKDEIYEKYVKEGKLNEAIERAKEIIKNYIKDMDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Y2</accession>
    <name>L0A9Y2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed RNA polymerase, subunit M/transcription elongation factor TFIIS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232127.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0462"/>
    <dbReference type="EnsemblBacteria" id="AFZ70229">
        <property type="protein sequence ID" value="AFZ70229"/>
        <property type="gene ID" value="Calag_0462"/>
    </dbReference>
    <dbReference type="GeneID" id="14211722"/>
    <dbReference type="KEGG" id="clg:Calag_0462"/>
    <dbReference type="eggNOG" id="arCOG00580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166550_0_0_2"/>
    <dbReference type="OMA" id="EYDQEEM"/>
    <dbReference type="OrthoDB" id="129143at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="DNA-dir_RNA_pol_M/15kDasu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="PTHR11239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPOL9" evidence="2">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="96" mass="10853" checksum="2E25E2F7C520559D" modified="2013-03-06" version="1">MMFCPKCGGVMVPIKKNGKVLLRCTKCGYEMEATSNAVNEYKSVSKTAEKEKVLTTKTVGQEENVNSEENKEELEQAKEDYYELVLDQMGEYGDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0A9Z2</accession>
    <name>L0A9Z2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232568.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0940"/>
    <dbReference type="EnsemblBacteria" id="AFZ70671">
        <property type="protein sequence ID" value="AFZ70671"/>
        <property type="gene ID" value="Calag_0940"/>
    </dbReference>
    <dbReference type="GeneID" id="14212200"/>
    <dbReference type="KEGG" id="clg:Calag_0940"/>
    <dbReference type="HOGENOM" id="CLU_961735_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="289" mass="31969" checksum="3E3319DD56FFF684" modified="2013-03-06" version="1" precursor="true">MKNIINVMLISILYSRSFLLLMITLSIPVALSSSLISVPYSISYSTHLIQTTNLNISMELYKFNNKNIMIFGSKNESYLLSYLNLNIITGKEGVLISGNLNKEVNSTISLCLNDGCKAYNISGIITSPYNITLIILPFNFNATQISLTNNGVNLALIGSSLSLIKLVLLLSIIILIFSIPAQVFSYEKMVNNMESTFANLKTMGLSKNNIIFYFIISSLIVSSLIILYGISLGIFIYQLGLFFLSRLNLVLPYGIPDPLIISLLFFISILTSLLSSLISIGERIDKISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA39</accession>
    <name>L0AA39_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,10-methylenetetrahydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231890.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0210"/>
    <dbReference type="EnsemblBacteria" id="AFZ69992">
        <property type="protein sequence ID" value="AFZ69992"/>
        <property type="gene ID" value="Calag_0210"/>
    </dbReference>
    <dbReference type="GeneID" id="14211470"/>
    <dbReference type="KEGG" id="clg:Calag_0210"/>
    <dbReference type="eggNOG" id="arCOG00475">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098912_0_0_2"/>
    <dbReference type="OMA" id="ERIIPYI"/>
    <dbReference type="OrthoDB" id="87262at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="240" mass="27977" checksum="5BEFB1F90067F64D" modified="2013-03-06" version="1">MKEILAELTPYNNKEKLLKYAKELIDYSDFIDIPDSPLGIPSPSSSILSCMIKEKFPEANIITNIRLYDINRLSLINSITALKMNKINHFLLVRGDMPKIGNKVDEIIPDDAIGFIRSMNIDGYFGLLLNLNKTIDEIELRIKKRASFYLITRPWFSEKIKQVSKMVREQKSKLYIYFVMLTDKNKEFLLNYLPKEELIHIDNLKESIQVVNDYVDGILFSSPMDHKGLVNSLRLFQKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA45</accession>
    <name>L0AA45_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleic-acid-binding protein containing a Zn-ribbon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231818.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0132"/>
    <dbReference type="EnsemblBacteria" id="AFZ69920">
        <property type="protein sequence ID" value="AFZ69920"/>
        <property type="gene ID" value="Calag_0132"/>
    </dbReference>
    <dbReference type="GeneID" id="14211392"/>
    <dbReference type="KEGG" id="clg:Calag_0132"/>
    <dbReference type="eggNOG" id="arCOG01288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119412_2_0_2"/>
    <dbReference type="OMA" id="TDIEYFE"/>
    <dbReference type="OrthoDB" id="120594at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="152" mass="17469" checksum="37303768DC9F0972" modified="2013-03-06" version="1">MSYDKKGRLDDLVIFPGEQEVEKYVYTPGIHGYDFAKGLKEGKILGMKCKDGKIYVPPKTFCPDFTQGEIIEIKDEWILVSYTIVYQDMYRNKLDNPKVIGVIKPKNAESGLIHLLNIPLDKLDIGIKVKPVFRPENERKGIINDIMYFELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA50</accession>
    <name>L0AA50_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">O-6-methylguanine DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Calag_1014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232633.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1014"/>
    <dbReference type="EnsemblBacteria" id="AFZ70736">
        <property type="protein sequence ID" value="AFZ70736"/>
        <property type="gene ID" value="Calag_1014"/>
    </dbReference>
    <dbReference type="GeneID" id="14212839"/>
    <dbReference type="KEGG" id="clg:Calag_1014"/>
    <dbReference type="eggNOG" id="arCOG02724">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_5_2"/>
    <dbReference type="OMA" id="DICEAVY"/>
    <dbReference type="OrthoDB" id="122341at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="7">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFZ70736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="103" mass="11736" checksum="617E89A0E474131E" modified="2013-03-06" version="1">MDEEILYDVLEFIPMGYVTTYKALGKFLGINQRKVAYLLKNNKNPIIVPCHRVVMSNGELGGYTPYGKNFKKSLLESEGVKIVNGKVDKKCIIEDLSLLEKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA56</accession>
    <name>L0AA56_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ69930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231828.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0143"/>
    <dbReference type="EnsemblBacteria" id="AFZ69930">
        <property type="protein sequence ID" value="AFZ69930"/>
        <property type="gene ID" value="Calag_0143"/>
    </dbReference>
    <dbReference type="GeneID" id="14211403"/>
    <dbReference type="KEGG" id="clg:Calag_0143"/>
    <dbReference type="eggNOG" id="arCOG00856">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2550062_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ69930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="82" mass="9594" checksum="4209E382879DB7D4" modified="2013-03-06" version="1">MAYIVPNSDNVTAESIIDYCIERMPSFWIPSYIIFVQSLPKTPLGRTEKYKLRVNVLPPGTKDMHDYIKKSCIVRKDLKNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AA66</accession>
    <name>L0AA66_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231915.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0235"/>
    <dbReference type="EnsemblBacteria" id="AFZ70017">
        <property type="protein sequence ID" value="AFZ70017"/>
        <property type="gene ID" value="Calag_0235"/>
    </dbReference>
    <dbReference type="GeneID" id="65348570"/>
    <dbReference type="KEGG" id="clg:Calag_0235"/>
    <dbReference type="eggNOG" id="arCOG04140">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179754_1_0_2"/>
    <dbReference type="OMA" id="VVHSIDM"/>
    <dbReference type="OrthoDB" id="126791at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003831">
        <property type="entry name" value="DUF211"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023129">
        <property type="entry name" value="MTH889-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42240">
        <property type="entry name" value="PTHR42240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02680">
        <property type="entry name" value="DUF211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160363">
        <property type="entry name" value="SSF160363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="94" mass="10090" checksum="7EF634A2B02A9E3C" modified="2013-03-06" version="1">MSAPLRRLVLNITKPIKGPSIIDVAKSIASLSGIDGVNVTVKELDVETATLNITIEGEDISFDKVENVLESLECVIQSIDQVITGKKVVDKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAB6</accession>
    <name>L0AAB6_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015231960.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0282"/>
    <dbReference type="EnsemblBacteria" id="AFZ70062">
        <property type="protein sequence ID" value="AFZ70062"/>
        <property type="gene ID" value="Calag_0282"/>
    </dbReference>
    <dbReference type="GeneID" id="14211542"/>
    <dbReference type="KEGG" id="clg:Calag_0282"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_1_0_2"/>
    <dbReference type="OMA" id="EWRKFKR"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="94" mass="11358" checksum="E9471E5ABE49F899" modified="2013-03-06" version="1">MVEQKKNRSRVKIYLDILETIEKEEKARLTRIMYNANIPYDRLLKYIDELKQKEIINEIVDNDSRYYVLTNKGKEFVKELKKIESFLRGFGLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAG3</accession>
    <name>L0AAG3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1144"/>
    <dbReference type="EnsemblBacteria" id="AFZ70866">
        <property type="protein sequence ID" value="AFZ70866"/>
        <property type="gene ID" value="Calag_1144"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1144"/>
    <dbReference type="eggNOG" id="arCOG04123">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142667_0_0_2"/>
    <dbReference type="OMA" id="MPREMLV"/>
    <dbReference type="OrthoDB" id="90815at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014450">
        <property type="entry name" value="UCP008210"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09921">
        <property type="entry name" value="DUF2153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008210">
        <property type="entry name" value="UCP008210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="144" mass="17173" checksum="262FBAC06FC1D289" modified="2013-03-06" version="1">MSQYRQDLGEFLKNLDRWISMQQAVLDTFKENYPKVRDSDRLDIIVNTRIAFNHMIRTLKAFDDWLQDPFITTNAPKELLLQVWDRTINILQQLILMDIEHTSSMRKMLDELSREGRINPLIARFREIGEERREEGRGTTTISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAG7</accession>
    <name>L0AAG7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0253"/>
    <dbReference type="EnsemblBacteria" id="AFZ70035">
        <property type="protein sequence ID" value="AFZ70035"/>
        <property type="gene ID" value="Calag_0253"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0253"/>
    <dbReference type="eggNOG" id="arCOG03702">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_336705_0_0_2"/>
    <dbReference type="OMA" id="ILATHEC"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="662"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="698"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="778"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="815"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="846" mass="97146" checksum="6BC5F780EF20733D" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAI1</accession>
    <name>L0AAI1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0270"/>
    <dbReference type="EnsemblBacteria" id="AFZ70050">
        <property type="protein sequence ID" value="AFZ70050"/>
        <property type="gene ID" value="Calag_0270"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0270"/>
    <dbReference type="eggNOG" id="arCOG04234">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142655_0_0_2"/>
    <dbReference type="OMA" id="YVGYPII"/>
    <dbReference type="OrthoDB" id="101808at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016618">
        <property type="entry name" value="UCP014422"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014422">
        <property type="entry name" value="UCP014422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="157" mass="18251" checksum="F0D706E7168FE0CE" modified="2013-03-06" version="1">MIKLKEPPKIKILEAAGAIADGRVHITKADNEYILAKVISSEKDKEYKIVIKKTEESFVVYSNDNGTKLRGYVGYPIISVMMLLGILSRDQNIEEALKGIDWRKLNETYKKYNIVEEIVLKKSENKVPRSYILEFRKNVMKELENMNIYYDENLSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAK2</accession>
    <name>L0AAK2_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulatory protein Calag_1191</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Calag_1191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232808.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1191"/>
    <dbReference type="EnsemblBacteria" id="AFZ70911">
        <property type="protein sequence ID" value="AFZ70911"/>
        <property type="gene ID" value="Calag_1191"/>
    </dbReference>
    <dbReference type="GeneID" id="14212451"/>
    <dbReference type="KEGG" id="clg:Calag_1191"/>
    <dbReference type="eggNOG" id="arCOG04152">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075726_1_0_2"/>
    <dbReference type="OMA" id="PGVVYFR"/>
    <dbReference type="OrthoDB" id="76134at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00584">
        <property type="entry name" value="HTH_type_cro_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020886">
        <property type="entry name" value="Arc_TR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="319" mass="36442" checksum="0ED521D583039129" modified="2013-03-06" version="1">MSDRRARDFLYKVIAELYNRSKYIEVLDYPRSMNRRSIDLAVQLNNGKFLLIKVAHDLEEVSKGEIEELLGLSLRLNIPSLIISEKNKGILMIDGIVYEKNGAKAVKLETLVSALENNDVFIYQDKESFKVKINPEKLKEKRMERNMSLGEIASLLHVSRRSVYEYERGTIEPSIELGEKLVNIFGDDILKPIDIFSEENLENVQIEEQPVDVVEERIISNQLKELGFITYHAKRTVLDIGAKNNKGNRLLIIVRHGKEGPSALSTKAQNLEKLSDTTNSASYVVSNDKNLIKELEIEKAKALTLEEFIEFLRDSFGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAP0</accession>
    <name>L0AAP0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="3">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Calag_1267</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1267"/>
    <dbReference type="EnsemblBacteria" id="AFZ70983">
        <property type="protein sequence ID" value="AFZ70983"/>
        <property type="gene ID" value="Calag_1267"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1267"/>
    <dbReference type="eggNOG" id="arCOG00912">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_2_2"/>
    <dbReference type="OMA" id="DGNNVCN"/>
    <dbReference type="OrthoDB" id="43727at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="13"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="160"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="277"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="318" mass="35698" checksum="69634B79C251F5BB" modified="2013-03-06" version="1">MAIIMSINELKGKDMLCLKDFSPEQVRYLIDLGLDLKRRYHAGERILNTLNGRSIAMIFEKPSTRTRVSLEVAAYQLGAQPIVLGWNELQLGRGEPIKDTARVLSRFVNGITARVRNHNDLIEMAKYASVPIINALSDLSHPMQVIADYMTIYEKKGKFKGLKFAFVGDGSDNMVHSLMIISSQLGVDFYVGSPKDLKPNEEILNAAKKFAEISGSKIVFTEDPFEAVDKADVVYTDVFVSMGQEDIAEAKKKILRPYQVNTKLMERADNKAIFLHCLPAHRGEEVTEEVIEGPWSAVWDEAENRLHSEKAILTSLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAP5</accession>
    <name>L0AAP5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0413"/>
    <dbReference type="EnsemblBacteria" id="AFZ70182">
        <property type="protein sequence ID" value="AFZ70182"/>
        <property type="gene ID" value="Calag_0413"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0413"/>
    <dbReference type="eggNOG" id="arCOG02216">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_558544_0_0_2"/>
    <dbReference type="OMA" id="NEWARTS"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="501" mass="56323" checksum="6D7C7129D5334D52" modified="2013-03-06" version="1">MKQEETKSQRLEAIRITTSRTVLYFLSILINIVATIVLARKLAPTDYAIYQLATKRIIQYATIPLSLAGLWIYRYLVERQKGSYIASFAFATIQFLITLIIGSLLIFIYAKPTPLLLVIASLSIAFQSFYYVIRTAIDAVRPVRLSLLELIYRTSYSLLIFIALYIISNSLILAFVSTLISFILTSTIGMLWLKDRILKDDSKNAKKTLKEWFLGSHATAVGVAFGLMPSLDALIAYPLIGSLIVAAFFVVSSVSTLLRDSTNVGLRYLHSYVLRTGDFRTALRNLEVSLALVIPFLVYGIMHPVYVIYVYNPIYSWASFSISIFLITAIIEIINNGISQIASGNIRESGIKGASKFTKMSLLGVIPSIIYLALIAFAFFVFRGMPIQDILIIWSIIYLIRYLLSVLITSHFFIPKNVNKNFATQLLPKLIFYISISLALSYFIKPIGPPSSRLLIDIKNLAIPGIIEAIIFYGILIAADKGIRRNLTLFIINFFKTFHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAQ5</accession>
    <name>L0AAQ5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0323"/>
    <dbReference type="EnsemblBacteria" id="AFZ70100">
        <property type="protein sequence ID" value="AFZ70100"/>
        <property type="gene ID" value="Calag_0323"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0323"/>
    <dbReference type="eggNOG" id="arCOG01921">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1736325_0_0_2"/>
    <dbReference type="OMA" id="QINIMEG"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002746">
        <property type="entry name" value="UPF0216"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01886">
        <property type="entry name" value="DUF61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="150" mass="17853" checksum="72E9BAF668B68F56" modified="2013-03-06" version="1">MVFTIGCKLILESNDKSIKSLQKKILDKINETQKLWPKETLNLIEVYNGKTSVLLESNEYHEFDKEEIKTVLEIVPQYFWKFIKLPILLRYNKDSEGRSWYNVLGDTWQKRFVEILITGQYSFDGIEELDVEMFLKILKKFKSLIFVSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAR0</accession>
    <name>L0AAR0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exosome complex component Rrp4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rrp4</name>
        <name evidence="5" type="ordered locus">Calag_0434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232100.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0434"/>
    <dbReference type="EnsemblBacteria" id="AFZ70202">
        <property type="protein sequence ID" value="AFZ70202"/>
        <property type="gene ID" value="Calag_0434"/>
    </dbReference>
    <dbReference type="GeneID" id="14211694"/>
    <dbReference type="KEGG" id="clg:Calag_0434"/>
    <dbReference type="eggNOG" id="arCOG00678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071769_0_0_2"/>
    <dbReference type="OMA" id="NWFVDIN"/>
    <dbReference type="OrthoDB" id="93052at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00623">
        <property type="entry name" value="Exosome_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023474">
        <property type="entry name" value="Rrp4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PTHR21321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="61"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFZ70202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="230" mass="25743" checksum="8DEEF6A51C0EC684" modified="2013-03-06" version="1">MSAIRKVLVPGEKIEGTINISDYYIYDYKNEKRVAIIGVVDYKQEGISYSPLNGIYIPKEGDIVIGLVTSHGVANWFVDINSPYQAILSVQDFFGTKQSSQFPEDPFKYLQVGEYIKAKIAAFDRIRNPLLTVQDKGLGKIAEGIVVSVHPTRVPRIIGKKGSMIEMLKNETGCEFFVAVNGMINIKCQNEQLESIASNAIKIIETQAHISGLTERVKKFIEEERKIRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAR2</accession>
    <name>L0AAR2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase, imidazolonepropionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0771"/>
    <dbReference type="EnsemblBacteria" id="AFZ70514">
        <property type="protein sequence ID" value="AFZ70514"/>
        <property type="gene ID" value="Calag_0771"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0771"/>
    <dbReference type="eggNOG" id="arCOG00696">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023620_2_2_2"/>
    <dbReference type="OMA" id="HCIDNGV"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="51"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="412" mass="44813" checksum="213F446BA7284D9E" modified="2013-03-06" version="1">MLENLRILDPESGYFNNGVIVIDNGLIKDFGSKGSIEIPKNANIIDCEGNTVMPGLIDAHLHVTGQRSGKIEERLTTPIGVFFARAVKDLENLVNAGFTTVVDAGSLIALHLRDAVNENTITGPRIIASGLPLSMTFGHADEHYMPIEYVDYRTSKKLTPFMSLICDGEDECRKATRYAMREGADFIKVMATGGVLSQRDRPEHRQFTLNELKAIVDEAQAANRWVHAHAQGTEGILNSLRAGVKVIAHAIYIDELASEEAKTRNAVVVPTLSIVQRLLDEGEKLGVPEWGLRKSAEVYEQHINAIKLAYKHGVKLATGTDFDGGIGRMGTNAMELKLFVEKIGMQPLEAIRAATMNAASAAGLEGKVGVIKKGAIADLIVVKGDPLNDINTLLNPNNIKLVFKEGNLIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAR5</accession>
    <name>L0AAR5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232905.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1294"/>
    <dbReference type="EnsemblBacteria" id="AFZ71008">
        <property type="protein sequence ID" value="AFZ71008"/>
        <property type="gene ID" value="Calag_1294"/>
    </dbReference>
    <dbReference type="GeneID" id="14212554"/>
    <dbReference type="KEGG" id="clg:Calag_1294"/>
    <dbReference type="eggNOG" id="arCOG05995">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188829_0_0_2"/>
    <dbReference type="OMA" id="EIETACI"/>
    <dbReference type="OrthoDB" id="130618at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="81" mass="9309" checksum="F2F83007CC92A2B5" modified="2013-03-06" version="1">MSKQDDSLNVIEVEGLAMDGLIKSFNVIDCEKPKGYKKIHAIAFDGREIETACIEPDAANRLTMVMNLYLRNWSKYINWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAR8</accession>
    <name>L0AAR8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal-transduction protein containing cAMP-binding and CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1300"/>
    <dbReference type="EnsemblBacteria" id="AFZ71013">
        <property type="protein sequence ID" value="AFZ71013"/>
        <property type="gene ID" value="Calag_1300"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1300"/>
    <dbReference type="eggNOG" id="arCOG00631">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_1_2"/>
    <dbReference type="OMA" id="KAITINY"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="126" mass="13769" checksum="4EA4A1A2061512B9" modified="2013-03-06" version="1">MKDILTKEKAITINYNTPISDVAKIMKEKGVDSVLIMKEDKIIGIFTEKDLVRAIADNASLNTPVSNYMSSKLITAKIDEPIVAIAYKMVESNIRHIPITNDQGTLLGVANIKDVLSLVLASGAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAV5</accession>
    <name>L0AAV5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="6">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_0376</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="6"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232048.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0376"/>
    <dbReference type="EnsemblBacteria" id="AFZ70150">
        <property type="protein sequence ID" value="AFZ70150"/>
        <property type="gene ID" value="Calag_0376"/>
    </dbReference>
    <dbReference type="GeneID" id="14211636"/>
    <dbReference type="KEGG" id="clg:Calag_0376"/>
    <dbReference type="eggNOG" id="arCOG01484">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_4_1_2"/>
    <dbReference type="OMA" id="CECGQEV"/>
    <dbReference type="OrthoDB" id="72994at2157"/>
    <dbReference type="UniPathway" id="UPA00275"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006401">
        <property type="entry name" value="Rib_reduct_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01508">
        <property type="entry name" value="rib_reduct_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="10">
        <location>
            <begin position="3"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="218" mass="24581" checksum="F1BE4232938A1CF9" modified="2013-03-06" version="1">MRPYVIIFSTMTVDGKIANSDGYSKLSCIDDFRLQHYLRSNSDGVMVGANTVINDDPSLTVRLVKGTSPYKIIVDSKLIVPLSSKIFQNPAKSIIITSNNLNKERYEKFEKIGVRIIKVDFNGVLDMVTALKNLYDIGIKRLMVEGGGHLNYSLLYNGLVDELWVTISPFAFGGGTSIFEKGILKEIKAEFYIKEIKNLCQNWVNIKYSILYPKKPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAY5</accession>
    <name>L0AAY5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232938.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1332"/>
    <dbReference type="EnsemblBacteria" id="AFZ71041">
        <property type="protein sequence ID" value="AFZ71041"/>
        <property type="gene ID" value="Calag_1332"/>
    </dbReference>
    <dbReference type="GeneID" id="14212592"/>
    <dbReference type="KEGG" id="clg:Calag_1332"/>
    <dbReference type="eggNOG" id="arCOG04261">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1253581_0_0_2"/>
    <dbReference type="OMA" id="SSNQHWW"/>
    <dbReference type="OrthoDB" id="105656at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ71041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="214" mass="24927" checksum="3549959693740C74" modified="2013-03-06" version="1">MEGEGTNLKEFLAKYGERGYYVLKSLLDASKTYKKAKLGDFDLRDVKDFLIKYGLDYNPVPLLAKLEKEYEIIRTTYKSGSQHWWNIIDKQSLEDALYSYDGTSTNNEDPKLKLLKIQFYSLDPERILNILEKMSKRKKITEDEKKELRKIAFNDLPRIVEFLTKAKSEYEDELISEIDIAEKIIDIAEGLIIGSNKSSVKKNVFKEIEFENEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAY8</accession>
    <name>L0AAY8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sterol carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0838"/>
    <dbReference type="EnsemblBacteria" id="AFZ70579">
        <property type="protein sequence ID" value="AFZ70579"/>
        <property type="gene ID" value="Calag_0838"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0838"/>
    <dbReference type="eggNOG" id="arCOG01842">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128031_0_0_2"/>
    <dbReference type="OMA" id="WEGDIIF"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="143" mass="16088" checksum="7AA65A32622D8DD6" modified="2013-03-06" version="1">MTKVGNVEFPSKEWSEIFCKKINENNNYKNAAKGWKWPLMFKVIKLPEDLQKKYPSGTIGIKADLFEGQCRGIEFYDDASKGNADFVLTAEYNDWMKILTGELNPVTAILQGKLKLEKGSMATVMRFPSAAVELVKSAQEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>L0AAZ8</accession>
    <name>L0AAZ8_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">50S ribosomal protein L24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpl24e</name>
        <name evidence="11" type="ordered locus">Calag_0437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232103.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0437"/>
    <dbReference type="EnsemblBacteria" id="AFZ70205">
        <property type="protein sequence ID" value="AFZ70205"/>
        <property type="gene ID" value="Calag_0437"/>
    </dbReference>
    <dbReference type="GeneID" id="14211697"/>
    <dbReference type="KEGG" id="clg:Calag_0437"/>
    <dbReference type="eggNOG" id="arCOG01950">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190191_0_0_2"/>
    <dbReference type="OMA" id="GTGKMYV"/>
    <dbReference type="OrthoDB" id="125162at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00773">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023438">
        <property type="entry name" value="Ribosomal_L24e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_L24e-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRASH" evidence="10">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ70205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="62" mass="7074" checksum="6185BB83089F258C" modified="2013-03-06" version="1">MPKEMICSFCGGIVEPGTGKMYIGPRGEIMWFCSSKCYKNSIKLGRKSRKLKWVTKLSKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB05</accession>
    <name>L0AB05_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">infB</name>
        <name evidence="9" type="ordered locus">Calag_0453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232118.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0453"/>
    <dbReference type="EnsemblBacteria" id="AFZ70220">
        <property type="protein sequence ID" value="AFZ70220"/>
        <property type="gene ID" value="Calag_0453"/>
    </dbReference>
    <dbReference type="GeneID" id="14211713"/>
    <dbReference type="KEGG" id="clg:Calag_0453"/>
    <dbReference type="eggNOG" id="arCOG01560">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002656_3_3_2"/>
    <dbReference type="OMA" id="FRQSKPA"/>
    <dbReference type="OrthoDB" id="17053at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_A">
        <property type="entry name" value="IF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004544">
        <property type="entry name" value="TF_aIF-2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00491">
        <property type="entry name" value="aIF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="13"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="22"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFZ70220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="620" mass="67960" checksum="3001B23FEF2C047C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB08</accession>
    <name>L0AB08_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0563"/>
    <dbReference type="EnsemblBacteria" id="AFZ70322">
        <property type="protein sequence ID" value="AFZ70322"/>
        <property type="gene ID" value="Calag_0563"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0563"/>
    <dbReference type="HOGENOM" id="CLU_3210571_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="44" mass="4843" checksum="EE697342AD94F54E" modified="2013-03-06" version="1">MAPGFTNFGLGAKNIKLKQKTKVFLNDFVFAPSLLLRTLEQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB17</accession>
    <name>L0AB17_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavin-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_0574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232230.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0574"/>
    <dbReference type="EnsemblBacteria" id="AFZ70332">
        <property type="protein sequence ID" value="AFZ70332"/>
        <property type="gene ID" value="Calag_0574"/>
    </dbReference>
    <dbReference type="GeneID" id="14211834"/>
    <dbReference type="KEGG" id="clg:Calag_0574"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066799_0_0_2"/>
    <dbReference type="OMA" id="ETAYFIF"/>
    <dbReference type="OrthoDB" id="112839at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="354" mass="40284" checksum="5E50FCD3822FABD6" modified="2013-03-06" version="1" precursor="true">MDVDVVIAGLGVSGSSLAYALSEKGYKINAYDPIKKYEKACGEQVSASYNSINLLKKSNSIVTMPNDISIYVNNKEVSNINFGGNTPWYIINKPNFIQYLRDSALSNGVNIIYKPWNNERGMITVDARGPFSGNLKDKILVKRYIVETEWDPNHVILDFRPNELGLYWIFPADDQGKLVNLGGGFVNLWDDEKLTKLIIEYARYNLKKVEVKNTKAAPLDVFSPYKPYSPSDNIFYVGEAAGLVLSISGEGNRPAIESSYALADAIRKHNLEDIYEIKNDYIRYSKKVANESFLSRKLFMFITKYKENFDMVNILSNIPKWFWYKYLSVSLEFNDVIKLGSDIKFILSIIKGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB24</accession>
    <name>L0AB24_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0479"/>
    <dbReference type="EnsemblBacteria" id="AFZ70245">
        <property type="protein sequence ID" value="AFZ70245"/>
        <property type="gene ID" value="Calag_0479"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0479"/>
    <dbReference type="eggNOG" id="arCOG01641">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2257215_0_0_2"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="38"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="103" mass="12069" checksum="79A4EEF121EC42CD" modified="2013-03-06" version="1">MYIVNRRRKQSEKEDLYRTDFYRLSSYPTYRNNDNREVLNQGDLIKVVIGNMDENGRGLASYKNYKVFVKGEVFPGDRVNVRIETIKGNTIVGTVEKVEERNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0AB43</accession>
    <name>L0AB43_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase (PilT family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0889"/>
    <dbReference type="EnsemblBacteria" id="AFZ70629">
        <property type="protein sequence ID" value="AFZ70629"/>
        <property type="gene ID" value="Calag_0889"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0889"/>
    <dbReference type="eggNOG" id="arCOG04116">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023387_0_0_2"/>
    <dbReference type="OrthoDB" id="19750at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="259"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="525" mass="59299" checksum="4A3742AB12A6D8BA" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABA3</accession>
    <name>L0ABA3_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Zn-dependent protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_0976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0976"/>
    <dbReference type="EnsemblBacteria" id="AFZ70699">
        <property type="protein sequence ID" value="AFZ70699"/>
        <property type="gene ID" value="Calag_0976"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0976"/>
    <dbReference type="eggNOG" id="arCOG00321">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_2_2"/>
    <dbReference type="OMA" id="MLYADYV"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_M" evidence="2">
        <location>
            <begin position="103"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="1">
        <location>
            <begin position="215"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="448" mass="49910" checksum="933CB25C51D18040" modified="2013-03-06" version="1">MEDKVNTLLSLGADFADIRYMKIKTLVADSSEIRNIITNNGISEGYALRALYKGNFGYKFTTNLENVDLKDVISLAIGKGETKVYQLKEKKDRIIIKEKYPNYKKPEEIIYDISKIKDDIFKSDKRIKSVNIRFSENSIEKRYASSDNRYIEVNYKITSLSISVVAKENDINASAHISLSTYLGYPLEVFDINESIEKVLNRVSKQLIGKPAKAGEARVILSPEVSGVFAHEALGHLAEADLAASGVLGKMKGKKIAKEFVNVSDSPFLEYPTAIGITPYDDEGVEGREVKIIENGVVKEFMNNRTYAFYTNELPSGNGRSEDFRSSILIRMRNTYFKPGKSSLEEMMEDIKEGYLMSSVLGGQTSSDGTFQFGIEEGYKIENGEIKYPLRNVGIAGYTLDTLSQISDISKDFAVWPGVCGKMGQRVYVGTGGPYVKVEKIKVGGVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABB2</accession>
    <name>L0ABB2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RecA-superfamily ATPase possibly involved in signal transduction</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232325.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0680"/>
    <dbReference type="EnsemblBacteria" id="AFZ70427">
        <property type="protein sequence ID" value="AFZ70427"/>
        <property type="gene ID" value="Calag_0680"/>
    </dbReference>
    <dbReference type="GeneID" id="14211940"/>
    <dbReference type="KEGG" id="clg:Calag_0680"/>
    <dbReference type="eggNOG" id="arCOG01174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046233_0_0_2"/>
    <dbReference type="OMA" id="RWAPIHQ"/>
    <dbReference type="OrthoDB" id="55361at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="459" mass="52302" checksum="6A55409BC12EE31A" modified="2013-03-06" version="1">MSLTKIGIKGLDEIFSKIYRGSIILIAGNPGTGKTTLGSKFLYEGLKNDENSIYLNFTETKKDFYRNMLNLGIDFEYYEKQGKFKYIEAITITDINALSDLLQELLDLIDKMNAKRLVIDSISAIMQLGEQNLGKIRELLHNFFYLGPKLKEVTTFLIAELPYGKKSVGYGVEEFIVDGVIILKIKIVKRKIIRLMEIRKMRGNEISIGEVPFVIAPDEGIAIIKPESPFGMPSAVNPEGIIELKFKDSNYKLEFQKGSQTLFVIHPSIDPLILLTALGVDIIISEKRKVFYRSYLHGENTIRDRFKICVNNLFSQEKANEIFDLVKTFSINPTRYSIDELYYMISKMESEIKADTVVVEGLETLYDLSDKRGFINAQYNSLIKMAVNGITGFYSTKGVKEEINQLPLINFYDNIIYAEPISTPNGRFVKITPIRLILKVNPYFEILLNADNIEKCTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABE8</accession>
    <name>L0ABE8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein S26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233078.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1479"/>
    <dbReference type="EnsemblBacteria" id="AFZ71181">
        <property type="protein sequence ID" value="AFZ71181"/>
        <property type="gene ID" value="Calag_1479"/>
    </dbReference>
    <dbReference type="GeneID" id="14212739"/>
    <dbReference type="KEGG" id="clg:Calag_1479"/>
    <dbReference type="eggNOG" id="arCOG04305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129451_3_0_2"/>
    <dbReference type="OMA" id="DKAICVT"/>
    <dbReference type="OrthoDB" id="117249at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_S26e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_S26e_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="PTHR12538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="95" mass="10808" checksum="0A417164F1E40B22" modified="2013-03-06" version="1">MPKKRESRGRRKGDKGKSKLIQCDNCGRLVPEDKAICVTRDYTPVDPQLAEELTKKGAIIPRYPVTKCYCISCAIHFGLVKIRAEDSRKPRTNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABI7</accession>
    <name>L0ABI7_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA primase DnaG</fullName>
            <ecNumber evidence="3">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dnaG</name>
        <name evidence="6" type="ordered locus">Calag_0753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="3"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0753"/>
    <dbReference type="EnsemblBacteria" id="AFZ70497">
        <property type="protein sequence ID" value="AFZ70497"/>
        <property type="gene ID" value="Calag_0753"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0753"/>
    <dbReference type="eggNOG" id="arCOG04281">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034626_0_0_2"/>
    <dbReference type="OMA" id="KYMIVAQ"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00007">
        <property type="entry name" value="DNA_primase_DnaG_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020607">
        <property type="entry name" value="Primase_DnaG_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1 3" id="KW-0271">Exosome</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0639">Primosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Toprim" evidence="5">
        <location>
            <begin position="165"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="425" mass="47857" checksum="2B59037CA71C57A5" modified="2013-03-06" version="1">MKYLIKASFEVDGRVDKHDVIGAVFGQTEGLLGSEFNLEQLQNKDKIGRVHIDMKYQGTKSVGILQIPSNLDRVETVLLAAMIESVDRVGPYTSRITIDDIQDLRIEKLQKIVERARQLLQRVKEQEPDIKEILREISQKPEVQAKVIEIGEERLPAGPDVEKADTIIIVEGRADVINLMKYGYTNTVALEGAREKVPQTIVELAKNKKVIAFVDGDRGGDLILKNLLDQVHVDYVARAPKDMEVEQLTGKEIARALSQMMPAEAVKQQLLSIKETKEEAEAAHEQTLPETQKIEKKEEIVQPETPSQQVVQEEKVEQKHELVSQLVVPKQVIDNIKNIKGTLEAIIYDRDWKEITRIKVRDLFTWLDTAQQNSAYAIIFDGIITQRILDLAGEKGIVLLIGARIGSKISSKRGDVKFATFSDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABJ4</accession>
    <name>L0ABJ4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1072"/>
    <dbReference type="EnsemblBacteria" id="AFZ70794">
        <property type="protein sequence ID" value="AFZ70794"/>
        <property type="gene ID" value="Calag_1072"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1072"/>
    <dbReference type="eggNOG" id="arCOG00156">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590033_0_0_2"/>
    <dbReference type="OMA" id="WANPPNI"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="485" mass="54164" checksum="DCF6BD20FBD89962" modified="2013-03-06" version="1">MSKKYKDSVSMKLLSSIIVVIIIIIGVAVFSLYYGSKQKLSTSTTIQTTSSSSSLPPQTITVFMYSGGGANFLNKTVIPMFEKQYPNIKVQLITVPYSQYFSAVSTAFQANSTQYDIVLYTHGTAYQFWPYLLPLNNSGINVSDLLNGAMADGGYYYNPTNGKNEMVGILFGSSFYILAYNTKLFNNTQLQQEFYNEYHFSLNPWTWKNWTQVLDVDQFFVSHNITKYGFLIADSASGNDIDYAYTAVYYWYYENNKTVSNGLPSGLPNWGIYFYGINSTGKFPMIALNTSVGIQALITYKELVNYEPNPLQLPVGYDNLPDLIAQNISPGAFMWNSQIDAIPKNYSKYLAFAPLPGGYAEPGPTFLGISKFSTHVKAAELFLQFLVSPQVQVLSSVPVSKIAFEQIISNTSIPYLIRERYNATLIASQKAYAGVGTGVPSQIPTLTTYLVDGIFSYLSNQTNNPQEVMNTITQKWINALQAYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABK9</accession>
    <name>L0ABK9_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Looped-hinge helix DNA binding domain, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232706.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1087"/>
    <dbReference type="EnsemblBacteria" id="AFZ70809">
        <property type="protein sequence ID" value="AFZ70809"/>
        <property type="gene ID" value="Calag_1087"/>
    </dbReference>
    <dbReference type="GeneID" id="14212347"/>
    <dbReference type="KEGG" id="clg:Calag_1087"/>
    <dbReference type="eggNOG" id="arCOG00318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_945268_0_0_2"/>
    <dbReference type="OMA" id="RYNGIAR"/>
    <dbReference type="OrthoDB" id="38423at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="292" mass="32061" checksum="6371050F751468CD" modified="2013-03-06" version="1">MSLNSTRRIQRLGGSSLIVTLPKQWAKKLGLKVGDELMILEEGDHLKLVPANNKAAIKAETVSIKYNGVAKIAGPKIIADCAFIHGYNRLNINVKGLDNIAYENLVKTLNENDKVENVVEGIDNVEVELLNPQEDDSSKLIKELNSKLQDMISIATNGEDVKSDLEKIRKEAEDISMTILRTSKKEGEQLDSIAYGLILSLPNLVYTYLVLSSKEKIIKDSQQLAIVLSDLLGGIASSSGRRILNAVKIASESKNNENSTLASIYSIIESIGTKLICPAIIDENMELDLEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABP2</accession>
    <name>L0ABP2_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLP-dependent enzyme, histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232741.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1122"/>
    <dbReference type="EnsemblBacteria" id="AFZ70844">
        <property type="protein sequence ID" value="AFZ70844"/>
        <property type="gene ID" value="Calag_1122"/>
    </dbReference>
    <dbReference type="GeneID" id="14212382"/>
    <dbReference type="KEGG" id="clg:Calag_1122"/>
    <dbReference type="eggNOG" id="arCOG04273">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_2_2"/>
    <dbReference type="OMA" id="WNINIFA"/>
    <dbReference type="OrthoDB" id="54638at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="345" mass="39634" checksum="C246E5277B99421B" modified="2013-03-06" version="1" precursor="true">MIKRNHGGTSNKNVIDFSSPTNPYGPPAISDDILKNCIKNKVYKYYPSYKKLNKALSDYWGIDEDNIIPVNGSDEALTLIPLALKLKKLIIIEPNFGDFDLMSKNLRIRLIRPLIKLDLEELYIDIDEIVKIANKNNSPVLFSRPNNPTGYCMKEKDLEYLSSNINNLLIVDEAFVEISSCNKIKPNENIIIVRSQTKTFSTPGLRLGEVISLNKNILNKIESSLQAWPIDSVTNCFYIKLFKEKEFIKEYLTLSNNLIFKEKEFIMSNLDLTKFKSNTSFILIRHEKIPNPLFKKKLIKRGILIRDASTFFGLDKSYSRISIKTHDENLILLNSIKGVLNEKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABR7</accession>
    <name>L0ABR7_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable thymidylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tmk</name>
        <name evidence="4" type="ordered locus">Calag_0746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0746"/>
    <dbReference type="EnsemblBacteria" id="AFZ70490">
        <property type="protein sequence ID" value="AFZ70490"/>
        <property type="gene ID" value="Calag_0746"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_0746"/>
    <dbReference type="eggNOG" id="arCOG01891">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_0_2_2"/>
    <dbReference type="OMA" id="QMAYLFA"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="3">
        <location>
            <begin position="12"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFZ70490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="219" mass="25103" checksum="F85C010D09E907CA" modified="2013-03-06" version="1">MQILEKGLLIAFEGIDGSGLTTHSKLLNEKLNKLGYKSIYTKEPTNNEIGILIQKIILDKNKKLDNNIIALLFAADRLYHLMYGDGANEGILSYISKNYIVISDRYKYSNMAYQGDDINWISQLNKFAIEADIIIYLDVPLDVALKRISMRSSVSIFENKIFLEKVKNRYNDILRLANKNGVKVVVINEIADNNREKSIDEVSEEILKNIINILRNFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-04-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABS0</accession>
    <name>L0ABS0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="1">4.2.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydroxymethylbilane = H2O + uroporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:18965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="EC" id="4.2.1.75"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uroporphyrinogen-III synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="1"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232771.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1152"/>
    <dbReference type="EnsemblBacteria" id="AFZ70874">
        <property type="protein sequence ID" value="AFZ70874"/>
        <property type="gene ID" value="Calag_1152"/>
    </dbReference>
    <dbReference type="GeneID" id="14212412"/>
    <dbReference type="KEGG" id="clg:Calag_1152"/>
    <dbReference type="eggNOG" id="arCOG02048">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_9_5_2"/>
    <dbReference type="OMA" id="CIILARS"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38042">
        <property type="entry name" value="PTHR38042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="2">
        <location>
            <begin position="22"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ70874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="244" mass="27958" checksum="384A75153C9B2193" modified="2013-03-06" version="1">MEKKLILYFGPDYPKHIEDKVDILFVPIIDIIPINGSSKIFYEKLKKCDWIVFTSPRGPRILVDDAKDNNILDSIINEIQSKKLGVVGPETAKSVKKYLYKDVDLMPKSYTGKELANELIKIRTDCIILARSSQGVKDINEILEKNNKKFIEVSIYDEIVNSERLSQVNNYLHENKNIDYIILSSPLIAKAFCDYIRYTNINVIAIGPSTLKEVKDRCPFLNVIVPNEYTLNSAIELIYRNPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABS1</accession>
    <name>L0ABS1_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NMD protein affecting ribosome stability and mRNA decay</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232392.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0751"/>
    <dbReference type="EnsemblBacteria" id="AFZ70495">
        <property type="protein sequence ID" value="AFZ70495"/>
        <property type="gene ID" value="Calag_0751"/>
    </dbReference>
    <dbReference type="GeneID" id="14212011"/>
    <dbReference type="KEGG" id="clg:Calag_0751"/>
    <dbReference type="eggNOG" id="arCOG04149">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065087_1_1_2"/>
    <dbReference type="OMA" id="CHMCGSY"/>
    <dbReference type="OrthoDB" id="105851at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="PTHR12746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMD3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="248" mass="28850" checksum="CD0AFAEAE7AA92C8" modified="2013-03-06" version="1">MPEKVCPVCGRSSNEVEFVDRFCRDCFIKYKGIAKIPDKVEFTYCNICGSYKYLGQWVSGLNSLEETLDSFLRIYVTEKMRPVNPIKEIYIKNIEFMESNQNFVNARITIEGIYNNLVLKEDKLLSIQLNKTICPICSSIKTQRGYNAIIQIRGYLGKIPPDLYAEVKREITDIMNRSRGEIIKVEEMKNNGIDLYIRDHSYARSLALKFKQEYMAKTIETYKLIGVNKDGSRKSRLYISVRIGELYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0ABV4</accession>
    <name>L0ABV4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232811.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1194"/>
    <dbReference type="EnsemblBacteria" id="AFZ70914">
        <property type="protein sequence ID" value="AFZ70914"/>
        <property type="gene ID" value="Calag_1194"/>
    </dbReference>
    <dbReference type="GeneID" id="14212454"/>
    <dbReference type="KEGG" id="clg:Calag_1194"/>
    <dbReference type="eggNOG" id="arCOG05934">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2581196_0_0_2"/>
    <dbReference type="OMA" id="WAYNISG"/>
    <dbReference type="OrthoDB" id="123457at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="80" mass="9244" checksum="807DE75D0B48938E" modified="2013-03-06" version="1">MENNQQDNEKDLVEILVSYKGSKVWAYNISGTSILVCPICKSSYFFSESDLMNHLISHAKGYIEKRRGTPSRQFIRREEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0AC56</accession>
    <name>L0AC56_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_0989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232609.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_0989"/>
    <dbReference type="EnsemblBacteria" id="AFZ70712">
        <property type="protein sequence ID" value="AFZ70712"/>
        <property type="gene ID" value="Calag_0989"/>
    </dbReference>
    <dbReference type="GeneID" id="14212249"/>
    <dbReference type="KEGG" id="clg:Calag_0989"/>
    <dbReference type="eggNOG" id="arCOG05489">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1412424_0_0_2"/>
    <dbReference type="OMA" id="YENIYEE"/>
    <dbReference type="OrthoDB" id="112189at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="172" mass="20422" checksum="12EDE07E7532E79F" modified="2013-03-06" version="1">MAIPIYGTGIFNVAKESIHYTIMFDYYDANKEYYNLIKRQSNKINEEKRLKEEMQKEINTEKTIINGNHVFPVIKYAKIGYKIPKISFVVFYIEIPFNLIKGKNTYENIYEETTAEYDYFVTWILPRCGKFIKIDSQGIYDIYGNYSFIFIQKGMKISGYESIVFELQDNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACK3</accession>
    <name>L0ACK3_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1444"/>
    <dbReference type="EnsemblBacteria" id="AFZ71149">
        <property type="protein sequence ID" value="AFZ71149"/>
        <property type="gene ID" value="Calag_1444"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1444"/>
    <dbReference type="eggNOG" id="arCOG05941">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143937_1_0_2"/>
    <dbReference type="OMA" id="YEYYGRY"/>
    <dbReference type="OrthoDB" id="112590at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="137" mass="16524" checksum="F8131A69198F3002" modified="2013-03-06" version="1">MGSELEKPNEPPSCKIKVYDGYIDIINILNEIKEKIYLYNTEISKKSYYLKPVHKVYKTKADKKKIIYEYYGRYWWKRINKKFIYSGIAKPKFLPNPPENPLEGLSIVREGNDVILDCSLYEKFKWIFKDRKVERTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACL4</accession>
    <name>L0ACL4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFZ70887">
        <property type="protein sequence ID" value="AFZ70887"/>
        <property type="gene ID" value="Calag_1166"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1166"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2190890_0_0_2"/>
    <dbReference type="OMA" id="EGPQTVM"/>
    <dbReference type="OrthoDB" id="139608at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="114" mass="12824" checksum="930C0F4E184029BB" modified="2013-03-06" version="1">MENNEVKPIKALIQCVSVPDYDLAAQILDYLLDKKELSVRDLTKVLSVSYPLVLRVVNDLAGLGIVETSKLKVEGRGRPRKLVKINVAKLLEMLDGCRKNLDEAEKVLKQKPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACQ5</accession>
    <name>L0ACQ5_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein translation factor SUI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232737.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1118"/>
    <dbReference type="EnsemblBacteria" id="AFZ70840">
        <property type="protein sequence ID" value="AFZ70840"/>
        <property type="gene ID" value="Calag_1118"/>
    </dbReference>
    <dbReference type="GeneID" id="14212378"/>
    <dbReference type="KEGG" id="clg:Calag_1118"/>
    <dbReference type="eggNOG" id="arCOG04223">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082805_6_1_2"/>
    <dbReference type="OMA" id="TIRDSWI"/>
    <dbReference type="OrthoDB" id="118816at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00604">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022851">
        <property type="entry name" value="SUI1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01158">
        <property type="entry name" value="SUI1_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ70840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="101" mass="11417" checksum="809D232E9899E687" modified="2013-03-06" version="1">MSKEVDCGGLPPDICEQLATEEQIIKIRLETRRFGKQVTVIEGIDEKQVNYKDLASKLKSELAAGGTYKDGRIELQGDHRKKVKDILIKMGFQPDNIMIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACS7</accession>
    <name>L0ACS7_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Calag_1138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232757.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1138"/>
    <dbReference type="EnsemblBacteria" id="AFZ70860">
        <property type="protein sequence ID" value="AFZ70860"/>
        <property type="gene ID" value="Calag_1138"/>
    </dbReference>
    <dbReference type="GeneID" id="14212398"/>
    <dbReference type="KEGG" id="clg:Calag_1138"/>
    <dbReference type="eggNOG" id="arCOG04251">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126372_0_0_2"/>
    <dbReference type="OMA" id="TSDFIIM"/>
    <dbReference type="OrthoDB" id="94611at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017006">
        <property type="entry name" value="UCP032756"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10051">
        <property type="entry name" value="DUF2286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFZ70860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="148" mass="16980" checksum="B25EF87445C2DDAD" modified="2013-03-06" version="1">MKIIVIRSEVGKIISSELMEGELDQIVKKKSEDAMKEWNPETSDFIVLRDIRELELPLPLDPELVDILRNVGTLSRTSEKAIARIPVYTISFENMMIGEDNYVEHKIYLISPYINDDIKTELEKEAVEITTEKAAPEGIEEEGEEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACU0</accession>
    <name>L0ACU0_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoenolpyruvate synthase</fullName>
            <shortName evidence="7">PEP synthase</shortName>
            <ecNumber evidence="7">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Calag_1546</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 7">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="7"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233141.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1546"/>
    <dbReference type="EnsemblBacteria" id="AFZ71244">
        <property type="protein sequence ID" value="AFZ71244"/>
        <property type="gene ID" value="Calag_1546"/>
    </dbReference>
    <dbReference type="GeneID" id="14212808"/>
    <dbReference type="KEGG" id="clg:Calag_1546"/>
    <dbReference type="eggNOG" id="arCOG01111">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007308_6_2_2"/>
    <dbReference type="OMA" id="LETWFFL"/>
    <dbReference type="OrthoDB" id="3139at2157"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01418">
        <property type="entry name" value="PEP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="9">
        <location>
            <begin position="21"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="8">
        <location>
            <begin position="391"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="10">
        <location>
            <begin position="479"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFZ71244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="797" mass="89038" checksum="C7D96647C03E015C" modified="2013-03-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACV8</accession>
    <name>L0ACV8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015233161.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1566"/>
    <dbReference type="EnsemblBacteria" id="AFZ71264">
        <property type="protein sequence ID" value="AFZ71264"/>
        <property type="gene ID" value="Calag_1566"/>
    </dbReference>
    <dbReference type="GeneID" id="14212828"/>
    <dbReference type="KEGG" id="clg:Calag_1566"/>
    <dbReference type="eggNOG" id="arCOG01458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_2"/>
    <dbReference type="OMA" id="WGLYNTK"/>
    <dbReference type="OrthoDB" id="56644at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ71264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="336" mass="36207" checksum="13C69FB24A67A323" modified="2013-03-06" version="1">MKAALVDKPFGLDRLSVTNVPDLRVSDEEVKIKVAYAGINPVDYFIISGSRAINPVPHIPGTEFGGYVEEVGSKVKGINKGDRVIVYPRIFDGICDLCLSGKEHLCRNGGLIGGITNGGFAEYAVVRYQNVIKIPNNLNWESAVSIPVAALTAFHALIEADVKPGETVVIVGASGNTGQFAVQLAKMMGAKVVAISSKPWVKNIGADEVVSLNQALNALQRVNNGRFADVVIDSIGSKTVERSVKLLDIGGRFVTFGALTGISARMTISEVYSKEIKIIGVTGGTRKEMLRLIEIASKNEIRPIIWKTFNLDDVKTAINSLFSRERNGRILLKIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>L0ACY5</accession>
    <name>L0ACY5_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Calag_1195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ70915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232812.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1195"/>
    <dbReference type="EnsemblBacteria" id="AFZ70915">
        <property type="protein sequence ID" value="AFZ70915"/>
        <property type="gene ID" value="Calag_1195"/>
    </dbReference>
    <dbReference type="GeneID" id="14212455"/>
    <dbReference type="KEGG" id="clg:Calag_1195"/>
    <dbReference type="eggNOG" id="arCOG00001">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_9_1_2"/>
    <dbReference type="OMA" id="ERPMYAY"/>
    <dbReference type="OrthoDB" id="105754at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFZ70915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="106" mass="12174" checksum="61D2E58EAE7CDF09" modified="2013-03-06" version="1">MSREGKISKAMARLIKNVTVHTLWIYVLAILARGSTYPYQVKKKIKDTFHFNPPTVTLYTVMYRLEKEGLIRKTENGSYEITEDGKIALKNASDTLKQLSETLDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>L0AD57</accession>
    <name>L0AD57_CALLD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Methionine aminopeptidase</fullName>
            <shortName evidence="3">MAP</shortName>
            <shortName evidence="3">MetAP</shortName>
            <ecNumber evidence="3 4">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">map</name>
        <name evidence="6" type="ordered locus">Calag_1363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="3 4">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015232969.1">
        <property type="nucleotide sequence ID" value="NC_019791.1"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1363"/>
    <dbReference type="EnsemblBacteria" id="AFZ71072">
        <property type="protein sequence ID" value="AFZ71072"/>
        <property type="gene ID" value="Calag_1363"/>
    </dbReference>
    <dbReference type="GeneID" id="14212623"/>
    <dbReference type="KEGG" id="clg:Calag_1363"/>
    <dbReference type="eggNOG" id="arCOG01001">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_7_0_2"/>
    <dbReference type="OMA" id="NEIAAHY"/>
    <dbReference type="OrthoDB" id="82853at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01975">
        <property type="entry name" value="MetAP_2_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028595">
        <property type="entry name" value="MetAP_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="9"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="301" mass="33513" checksum="0C58E3ABDC002409" modified="2013-03-06" version="1">MFSNEEIEKLIKAGKIGAEARDLGASLVKPGASSREICDEVENYIIKKGADIAFPCNLSINEIAAHYTPGIEDDMKIPSMGIIKIDVGASIDGYLSDTATSVIIGDQFKELAMSVKKALENVINIMKPNISIYDIGKTIEMSIKSQGFRPIKNLTGHTISRYNLHAGESIPNYPDRTMFYKRLRPGTQVAIEPFGTFGKGFVIDGPKAFIYSLTGRKPKNISEDAKQLLEYIEKKYNALPFAARWLIKEFEKSKVEDLLNELTMQKALVDYPILIEAGRGIVAQYEHTFLILNDRVIVTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADL4</accession>
    <name>L0ADL4_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative threonine efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Calag_1522</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1522"/>
    <dbReference type="EnsemblBacteria" id="AFZ71222">
        <property type="protein sequence ID" value="AFZ71222"/>
        <property type="gene ID" value="Calag_1522"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1522"/>
    <dbReference type="eggNOG" id="arCOG01947">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104651_0_0_2"/>
    <dbReference type="OMA" id="NPYFWIW"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFZ71222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="223" mass="25136" checksum="55A8D528F895D036" modified="2013-03-06" version="1">MQSLELYYLIILTITLSVSGAFSPGPLTFSAIIEGSKGSWFSGFKEAFGHLLFELPFVFLLALFLQQIKSLLNDIIIKYFLSFILISFIIYFSLIAIKDGYNRIKDNGSLINQNFSNNSKISNRPIITGFVLTASNPLFLSWWATVGLILILSATTLGFIYGLSIMYASHVWMDFFWLGTMGIIGKSGKKLLNNKQFGVFLILMAFIMFYFGIMASLQLINFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-03-06" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>L0ADN8</accession>
    <name>L0ADN8_CALLD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA-binding protein, snRNP like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Calag_1445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)</name>
        <dbReference type="NCBI Taxonomy" id="1056495"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Acidilobales</taxon>
            <taxon>Caldisphaeraceae</taxon>
            <taxon>Caldisphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome of Caldisphaera lagunensis DSM 15908.</title>
            <authorList>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Dalin E."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Peters L."/>
                <person name="Mikhailova N."/>
                <person name="Teshima H."/>
                <person name="Kyrpides N."/>
                <person name="Mavromatis K."/>
                <person name="Ivanova N."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Markowitz V."/>
                <person name="Cheng J.-F."/>
                <person name="Hugenholtz P."/>
                <person name="Woyke T."/>
                <person name="Wu D."/>
                <person name="Spring S."/>
                <person name="Schroeder M."/>
                <person name="Brambilla E."/>
                <person name="Klenk H.-P."/>
                <person name="Eisen J.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 15908 / JCM 11604 / IC-154</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003378">
        <property type="protein sequence ID" value="AFZ71150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1056495.Calag_1445"/>
    <dbReference type="EnsemblBacteria" id="AFZ71150">
        <property type="protein sequence ID" value="AFZ71150"/>
        <property type="gene ID" value="Calag_1445"/>
    </dbReference>
    <dbReference type="KEGG" id="clg:Calag_1445"/>
    <dbReference type="eggNOG" id="arCOG01695">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003612_2_1_2"/>
    <dbReference type="OMA" id="MVYGKRN"/>
    <dbReference type="OrthoDB" id="69351at2157"/>
    <dbReference type="Proteomes" id="UP000010469">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="2">
        <location>
            <begin position="451"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFZ71150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000010469"/>
        </source>
    </evidence>
    <sequence length="669" mass="77182" checksum="B81551EFDCF4EAEF" modified="2013-03-06" version="1"> </sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>